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UY31674A1 - Derivado heterocíclico fusionado y su uso - Google Patents

Derivado heterocíclico fusionado y su uso

Info

Publication number
UY31674A1
UY31674A1 UY031674A UY31674A UY31674A1 UY 31674 A1 UY31674 A1 UY 31674A1 UY 031674 A UY031674 A UY 031674A UY 31674 A UY31674 A UY 31674A UY 31674 A1 UY31674 A1 UY 31674A1
Authority
UY
Uruguay
Prior art keywords
fused heterocyclic
ring
heterocyclic derivative
provides
present
Prior art date
Application number
UY031674A
Other languages
English (en)
Inventor
Yuya Oguro
Shigeru Kondo
Satoshi Sasaki
Nobuhiro Fujii
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of UY31674A1 publication Critical patent/UY31674A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención provee un compuesto que tiene una actividad inhibidora de Smo superior y baja toxicidad, que es suficientemente satisfactoria como producto farmacéutico. La presente invención provee un compuesto representado por la fórmula en el cual anillo A es anillo de 5 a 7 miembros que tiene sustituyente (s) en forma opcional, donde los sustituyentes están unidos en forma opcional entre sí para formar un anillo.
UY031674A 2005-07-05 2009-02-25 Derivado heterocíclico fusionado y su uso UY31674A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005196866 2005-07-05
JP2006054102 2006-02-28

Publications (1)

Publication Number Publication Date
UY31674A1 true UY31674A1 (es) 2009-08-31

Family

ID=37055938

Family Applications (1)

Application Number Title Priority Date Filing Date
UY031674A UY31674A1 (es) 2005-07-05 2009-02-25 Derivado heterocíclico fusionado y su uso

Country Status (8)

Country Link
US (1) US20090137580A1 (es)
EP (1) EP1904498A1 (es)
JP (1) JP2009500295A (es)
AR (1) AR055071A1 (es)
PE (1) PE20070174A1 (es)
TW (1) TW200740820A (es)
UY (1) UY31674A1 (es)
WO (1) WO2007004749A1 (es)

Families Citing this family (33)

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Publication number Priority date Publication date Assignee Title
JP5148499B2 (ja) * 2005-05-20 2013-02-20 メチルジーン インコーポレイテッド Ｖｅｇｆ受容体およびｈｇｆ受容体シグナル伝達の阻害剤
US8592433B2 (en) * 2005-10-28 2013-11-26 Advait Nagle Compounds and compositions as protein kinase inhibitors
TW200730527A (en) * 2005-12-02 2007-08-16 Takeda Pharmaceuticals Co Fused heterocyclic compound
NZ551796A (en) * 2006-12-05 2009-07-31 Craig Robert Stuart Bump-resistant pin tumbler lock
US8450336B2 (en) 2006-12-14 2013-05-28 Nps Pharmaceuticals, Inc Use of D-serine derivatives for the treatment of anxiety disorders
AU2008293038B2 (en) 2007-08-29 2013-08-29 Mirati Therapeutics, Inc. Inhibitors of protein tyrosine kinase activity
JPWO2009096435A1 (ja) * 2008-01-29 2011-05-26 武田薬品工業株式会社 縮合複素環誘導体およびその用途
NZ589336A (en) * 2008-03-05 2011-12-22 Methylgene Inc Pyridine derivatives as inhibitors of protein tyrosine kinase activity
US8445509B2 (en) 2008-05-08 2013-05-21 Takeda Pharmaceutical Company Limited Fused heterocyclic derivatives and use thereof
WO2010108503A1 (en) 2009-03-24 2010-09-30 Life & Brain Gmbh Promotion of neuronal integration in neural stem cell grafts
US9951008B2 (en) * 2009-11-03 2018-04-24 University Of Notre Dame Du Lac Ionic liquids comprising heteraromatic anions
US8912184B1 (en) 2010-03-01 2014-12-16 Alzheimer's Institute Of America, Inc. Therapeutic and diagnostic methods
WO2011109441A1 (en) * 2010-03-01 2011-09-09 Myrexis, Inc. Compounds and therapeutic uses thereof
WO2011121555A1 (en) 2010-03-31 2011-10-06 Actelion Pharmaceuticals Ltd Antibacterial isoquinolin-3-ylurea derivatives
WO2012008564A1 (ja) * 2010-07-16 2012-01-19 協和発酵キリン株式会社 含窒素芳香族複素環誘導体
AR088729A1 (es) 2011-03-29 2014-07-02 Actelion Pharmaceuticals Ltd Derivados de 3-ureidoisoquinolin-8-ilo y una composicion farmaceutica
JP6200893B2 (ja) 2011-10-31 2017-09-20 ノバルティス アーゲー パゾパニブ製剤
MX363950B (es) 2013-04-02 2019-04-08 Topivert Pharma Ltd Derivados de urea utiles como inhibidores de quinasa.
SI3049417T1 (sl) 2013-07-31 2019-03-29 Merck Patent Gmbh Piridini, pirimidini in pirazini kot inhibitorji BTK in njihove uporabe
US10385251B2 (en) 2013-09-30 2019-08-20 University Of Notre Dame Du Lac Compounds, complexes, compositions, methods and systems for heating and cooling
US10086331B2 (en) 2013-11-05 2018-10-02 University Of Notre Dame Du Lac Carbon dioxide capture using phase change ionic liquids
AU2014369449B2 (en) 2013-12-20 2018-07-05 Oxular Acquisitions Limited Urea derivatives useful as kinase inhibitors
MA40775A (fr) 2014-10-01 2017-08-08 Respivert Ltd Dérivé d'acide 4-(4-(4-phényluréido-naphtalén -1-yl) oxy-pyridin-2-yl) amino-benzoïque utilisé en tant qu'inhibiteur de la kinase p38
MX2018002018A (es) 2015-08-31 2018-03-26 Toray Industries Derivado de urea y uso del mismo.
KR102387073B1 (ko) 2016-04-06 2022-04-15 옥슬러 액퀴지션즈 리미티드 키나제 저해제
US10196378B2 (en) * 2016-08-25 2019-02-05 The Regents Of The University Of Michigan Inhibitors of BCR-ABL mutants and use thereof
CN109180677A (zh) * 2017-06-30 2019-01-11 厦门大学 取代芳基醚类化合物、其制备方法、药用组合物及其应用
WO2020188015A1 (en) 2019-03-21 2020-09-24 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
CN110128299B (zh) * 2019-05-13 2020-11-10 浙江大学 一种二苯基脲类抗肿瘤小分子抑制剂及其制备方法
WO2020245208A1 (en) 2019-06-04 2020-12-10 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of cd9 as a biomarker and as a biotarget in glomerulonephritis or glomerulosclerosis
WO2021089791A1 (en) 2019-11-08 2021-05-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
CN116789670A (zh) * 2022-03-17 2023-09-22 中国科学院合肥物质科学研究院 一种选择性csf1r抑制剂及其用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL112249A (en) * 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
AR004010A1 (es) * 1995-10-11 1998-09-30 Glaxo Group Ltd Compuestos heterociclicos
AR007855A1 (es) * 1996-07-13 1999-11-24 Glaxo Group Ltd Compuestos heterociclicos fusionados como inhibidores de proteina tirosina quinasa, sus metodos de preparacion, intermediarios, uso en medicinay composiciones farmaceuticas que los contienen
NZ333302A (en) 1996-08-28 2000-08-25 Pfizer Substituted 6,5-hetero-bicyclic derivatives for the prevention or inhibition of a disorder that can be treated by antagonising corticotropin releasing factor
CN1183114C (zh) * 1999-01-22 2005-01-05 麒麟麦酒株式会社 喹啉衍生物及喹唑啉衍生物
WO2001083456A1 (fr) 2000-04-27 2001-11-08 Yamanouchi Pharmaceutical Co., Ltd. Derives d'heteroaryle condenses
KR100589032B1 (ko) * 2000-10-20 2006-06-14 에자이 가부시키가이샤 질소 함유 방향환 유도체
ES2256466T3 (es) * 2001-04-27 2006-07-16 Kirin Beer Kabushiki Kaisha Derivado de quinolina que tienen grupo azolilo y derivados de quinazolina.
KR101194622B1 (ko) * 2004-06-02 2012-10-29 다케다 야쿠힌 고교 가부시키가이샤 접합 헤테로시클릭 화합물

Also Published As

Publication number Publication date
WO2007004749A1 (en) 2007-01-11
EP1904498A1 (en) 2008-04-02
TW200740820A (en) 2007-11-01
AR055071A1 (es) 2007-08-01
PE20070174A1 (es) 2007-03-12
JP2009500295A (ja) 2009-01-08
US20090137580A1 (en) 2009-05-28

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20181017