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UY29398A1 - Derivados de quinazolinas, sussales farmacéuticamente aceptables, composiciones que los contienen, procedimientos de preparación y aplicacións. - Google Patents

Derivados de quinazolinas, sussales farmacéuticamente aceptables, composiciones que los contienen, procedimientos de preparación y aplicacións.

Info

Publication number
UY29398A1
UY29398A1 UY29398A UY29398A UY29398A1 UY 29398 A1 UY29398 A1 UY 29398A1 UY 29398 A UY29398 A UY 29398A UY 29398 A UY29398 A UY 29398A UY 29398 A1 UY29398 A1 UY 29398A1
Authority
UY
Uruguay
Prior art keywords
pharmaceutically acceptable
derivatives
sussales
quinazolinas
compositions
Prior art date
Application number
UY29398A
Other languages
English (en)
Inventor
Christopher Thomas Halsall
Laurent Francois And Hennequin
Alleyn Thomas Plowright
Richard Storey
Kieran Lennon
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36390222&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY29398(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0504018A external-priority patent/GB0504018D0/en
Priority claimed from GB0506657A external-priority patent/GB0506657D0/en
Priority claimed from GB0524001A external-priority patent/GB0524001D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of UY29398A1 publication Critical patent/UY29398A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invención se refiere a derivados de quinazolina de la fómula I,o sales farmacéuticamente aceptables del mismo: en donde cada R2, R2, R3, R4, y m son según se define en la descripción; procesos para la preparación; composiciones farmacéuticas que los contienen y su uso en la fabricación de un medicamento para proporcionar un efecto antiproliferativo. Se espera que los derivados de quinazolina de fórmula I resulten útiles en el tratamiento de enfermedades como ciertos cánceres mediados por el receptor erbB de tin tirosinquinasa, en particular EGFR de tirosinquinasa.
UY29398A 2005-02-26 2006-02-24 Derivados de quinazolinas, sussales farmacéuticamente aceptables, composiciones que los contienen, procedimientos de preparación y aplicacións. UY29398A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0504018A GB0504018D0 (en) 2005-02-26 2005-02-26 Quinazoline derivatives
GB0506657A GB0506657D0 (en) 2005-03-31 2005-03-31 Quinazoline derivatives
GB0524001A GB0524001D0 (en) 2005-11-25 2005-11-25 Quinazoline derivatives

Publications (1)

Publication Number Publication Date
UY29398A1 true UY29398A1 (es) 2006-10-02

Family

ID=36390222

Family Applications (1)

Application Number Title Priority Date Filing Date
UY29398A UY29398A1 (es) 2005-02-26 2006-02-24 Derivados de quinazolinas, sussales farmacéuticamente aceptables, composiciones que los contienen, procedimientos de preparación y aplicacións.

Country Status (15)

Country Link
US (1) US8735410B2 (es)
EP (1) EP1856095B1 (es)
JP (1) JP5054544B2 (es)
KR (1) KR20070107151A (es)
AR (1) AR055564A1 (es)
AT (1) ATE521603T1 (es)
AU (1) AU2006217738A1 (es)
BR (1) BRPI0607432A2 (es)
CA (1) CA2599210A1 (es)
IL (1) IL184798A0 (es)
MX (1) MX2007010399A (es)
NO (1) NO20073878L (es)
TW (1) TW200640904A (es)
UY (1) UY29398A1 (es)
WO (1) WO2006090163A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8629153B2 (en) 2008-09-03 2014-01-14 Boehringer Ingelheim International Gmbh Use of quinazoline derivatives for the treatment of viral diseases
KR20140096571A (ko) * 2013-01-28 2014-08-06 한미약품 주식회사 1-(4-(4-(3,4-디클로로-2-플루오로페닐아미노)-7-메톡시퀴나졸린-6-일옥시)피페리딘-1-일)프로프-2-엔-1-온의 제조방법
CN103288759B (zh) * 2013-05-16 2015-05-20 苏州明锐医药科技有限公司 达克米替尼的制备方法
EP3253739A4 (en) * 2015-02-03 2018-07-18 Trillium Therapeutics Inc. Novel fluorinated derivatives as egfr inhibitors useful for treating cancers
EP3689351B1 (en) 2017-09-28 2022-11-02 Chongqing Pharmaceutical Industrial Research Institute Co. Ltd. Quinoline derivative and application thereof as tyrosine kinase inhibitor
MX2021002875A (es) * 2018-09-14 2021-07-15 Hanmi Pharmaceutical Co Ltd Formas cristalinas de un compuesto de quinazolina y sus sales clorhidrato.

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Also Published As

Publication number Publication date
ATE521603T1 (de) 2011-09-15
EP1856095A1 (en) 2007-11-21
MX2007010399A (es) 2007-09-25
WO2006090163A1 (en) 2006-08-31
US20110152297A1 (en) 2011-06-23
TW200640904A (en) 2006-12-01
JP2008531536A (ja) 2008-08-14
AU2006217738A1 (en) 2006-08-31
CA2599210A1 (en) 2006-08-31
NO20073878L (no) 2007-10-23
KR20070107151A (ko) 2007-11-06
AR055564A1 (es) 2007-08-22
JP5054544B2 (ja) 2012-10-24
IL184798A0 (en) 2007-12-03
EP1856095B1 (en) 2011-08-24
BRPI0607432A2 (pt) 2009-09-01
US8735410B2 (en) 2014-05-27

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Effective date: 20120426