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CR10056A - [(1h-indol-5-il)-heteroariloxi]-(1-aza-biciclo[3.3.1]nonanos como ligandos colinérgicos del n-achr para el tratamiento de trastornos piscóticos y neurodegenerativos - Google Patents

[(1h-indol-5-il)-heteroariloxi]-(1-aza-biciclo[3.3.1]nonanos como ligandos colinérgicos del n-achr para el tratamiento de trastornos piscóticos y neurodegenerativos

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Publication number
CR10056A
CR10056A CR10056A CR10056A CR10056A CR 10056 A CR10056 A CR 10056A CR 10056 A CR10056 A CR 10056A CR 10056 A CR10056 A CR 10056A CR 10056 A CR10056 A CR 10056A
Authority
CR
Costa Rica
Prior art keywords
aza
treatment
neurodegenerative disorders
piscotic
heteroariloxi
Prior art date
Application number
CR10056A
Other languages
English (en)
Inventor
Feuerbach Dominik
Frederiksen Mathias
Hurth Konstanze
Lucien Roy Bernard
Wagner Bratrix
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35736290&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR10056(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CR10056A publication Critical patent/CR10056A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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Abstract

La presente invención se refiere a derivados de 1-aza-biciclo-alquilo de la Fórmula (I): en donde los sustituyentes son como se definen en la memoria descriptiva, y a los proceso para su producción, a composiciones farmacéuticas que los comprenden y a su uso en la fabricación de un medicamento para el tratamiento y/o demora del progreso de trastornos piscóticos y neurodegenerativos.
CR10056A 2005-12-16 2008-06-09 [(1h-indol-5-il)-heteroariloxi]-(1-aza-biciclo[3.3.1]nonanos como ligandos colinérgicos del n-achr para el tratamiento de trastornos piscóticos y neurodegenerativos CR10056A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0525672.2A GB0525672D0 (en) 2005-12-16 2005-12-16 Organic compounds

Publications (1)

Publication Number Publication Date
CR10056A true CR10056A (es) 2008-08-27

Family

ID=35736290

Family Applications (1)

Application Number Title Priority Date Filing Date
CR10056A CR10056A (es) 2005-12-16 2008-06-09 [(1h-indol-5-il)-heteroariloxi]-(1-aza-biciclo[3.3.1]nonanos como ligandos colinérgicos del n-achr para el tratamiento de trastornos piscóticos y neurodegenerativos

Country Status (35)

Country Link
US (4) US7713976B2 (es)
EP (2) EP2361914A1 (es)
JP (1) JP5230441B2 (es)
KR (2) KR20120018383A (es)
CN (1) CN101331132B (es)
AR (1) AR058348A1 (es)
AT (1) ATE529427T1 (es)
AU (1) AU2006326258B2 (es)
BR (1) BRPI0619888A2 (es)
CA (1) CA2631654C (es)
CR (1) CR10056A (es)
CY (1) CY1112708T1 (es)
DK (1) DK1966209T3 (es)
EC (1) ECSP088541A (es)
ES (1) ES2375847T3 (es)
GB (1) GB0525672D0 (es)
HK (1) HK1121444A1 (es)
HR (1) HRP20120030T1 (es)
IL (1) IL191841A (es)
JO (1) JO2734B1 (es)
MA (1) MA30027B1 (es)
MY (1) MY145627A (es)
NO (1) NO20082937L (es)
NZ (1) NZ569013A (es)
PE (1) PE20070750A1 (es)
PL (1) PL1966209T3 (es)
PT (1) PT1966209E (es)
RU (1) RU2471797C2 (es)
SA (1) SA06270445B1 (es)
SI (1) SI1966209T1 (es)
TN (1) TNSN08260A1 (es)
TW (1) TWI423965B (es)
UA (1) UA94725C2 (es)
WO (1) WO2007068476A1 (es)
ZA (1) ZA200804628B (es)

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GB0220581D0 (en) 2002-09-04 2002-10-09 Novartis Ag Organic Compound
PE20060437A1 (es) 2004-06-18 2006-06-08 Novartis Ag COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR
GB0415746D0 (en) 2004-07-14 2004-08-18 Novartis Ag Organic compounds
GB0521508D0 (en) 2005-10-21 2005-11-30 Novartis Ag Organic compounds
TWI403320B (zh) * 2005-12-16 2013-08-01 Infinity Discovery Inc 用於抑制ｂｃｌ蛋白和結合夥伴間之交互作用的化合物及方法
GB0525673D0 (en) * 2005-12-16 2006-01-25 Novartis Ag Organic compounds
GB0525672D0 (en) * 2005-12-16 2006-01-25 Novartis Ag Organic compounds
WO2011009890A2 (en) 2009-07-23 2011-01-27 Novartis Ag Use of azabicycloalkyl derivatives or pyrrolidine-2-one derivatives
TWI558398B (zh) 2009-09-22 2016-11-21 諾華公司 菸鹼乙醯膽鹼受體α７活化劑之用途
JP5734999B2 (ja) * 2009-12-17 2015-06-17 アッヴィ・インコーポレイテッド 神経変性および神経精神医学的障害の治療に有用な架橋アミン環縮合インドールおよびインドリン
BR112013018726A2 (pt) 2011-01-27 2016-10-25 Novartis Ag uso de ativadores de alfa 7 do receptor nicotínico de acetilcolina
EA201391348A8 (ru) 2011-03-18 2014-11-28 Новартис Аг КОМБИНАЦИИ АКТИВАТОРОВ АЛЬФА-7 НИКОТИНОВОГО АЦЕТИЛХОЛИНОВОГО РЕЦЕПТОРА И АНТАГОНИСТОВ mGluR5, ПРЕДНАЗНАЧЕННЫЕ ДЛЯ ПРИМЕНЕНИЯ ПРИ ВЫЗВАННОЙ ДОПАМИНОМ ДИСКИНЕЗИИ, СВЯЗАННОЙ С БОЛЕЗНЬЮ ПАРКИНСОНА
ES2776996T3 (es) 2011-10-20 2020-08-03 Novartis Ag Biomarcadores predictivos de la sensibilidad al tratamiento por el activador del receptor de la acetilcolina nicotínico alfa 7
KR20190102104A (ko) 2012-12-11 2019-09-02 노파르티스 아게 알파 7 니코틴성 아세틸콜린 수용체 활성화제 치료에 대한 반응성의 예측 바이오마커
EP2945633B1 (en) 2013-01-15 2021-06-30 Novartis AG Use of alpha 7 nicotinic acetylcholine receptor agonists
US20150313884A1 (en) 2013-01-15 2015-11-05 Novartis Ag Use of alpha 7 nicotinic acetylcholine receptor agonists
KR101879919B1 (ko) 2013-01-15 2018-07-18 노파르티스 아게 알파 7 니코틴성 아세틸콜린 수용체 작용물질의 용도
CA2898043C (en) 2013-01-15 2019-08-06 Novartis Ag Use of alpha 7 nicotinic receptor agonists for the treatment of narcolepsy

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