[go: up one dir, main page]

USRE45404E1 - Powder medicine applicator for nasal cavity - Google Patents

Powder medicine applicator for nasal cavity Download PDF

Info

Publication number
USRE45404E1
USRE45404E1 US12/576,219 US57621909A USRE45404E US RE45404 E1 USRE45404 E1 US RE45404E1 US 57621909 A US57621909 A US 57621909A US RE45404 E USRE45404 E US RE45404E
Authority
US
United States
Prior art keywords
capsule
medicine
pump
housing
detaching
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
US12/576,219
Other languages
English (en)
Inventor
Tatsuo Tsutsui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shin Nippon Biomedical Laboratories Ltd
Original Assignee
Shin Nippon Biomedical Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shin Nippon Biomedical Laboratories Ltd filed Critical Shin Nippon Biomedical Laboratories Ltd
Priority to US12/576,219 priority Critical patent/USRE45404E1/en
Application granted granted Critical
Publication of USRE45404E1 publication Critical patent/USRE45404E1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/08—Inhaling devices inserted into the nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M13/00—Insufflators for therapeutic or disinfectant purposes, i.e. devices for blowing a gas, powder or vapour into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0038—Cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0041—Details of the piercing or cutting means with movable piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/07—General characteristics of the apparatus having air pumping means
    • A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
    • A61M2205/075—Bulb type

Definitions

  • the present invention concerns an optimal device to deliver powdery medicine dosing into the nasal cavity.
  • a treatment method to deliver a powdery medicine into the nasal cavity of a patient suffering from asthma or nasal allergy has been known generally.
  • a powdery medicine filled in a capsule is administered into the nasal cavity using a special delivery device.
  • JP-A No. 59-34267 (hereinafter referred to as prior art) has proposed a delivery device used for the treatment.
  • the device of the prior art comprises a cylindrical member having a pump on the air inlet and a concave part in which a capsule is inserted on the air exit of the cylindrical member.
  • a top end part is fitted into the concave part to form a capsule housing part, and an air guide passage having a valve mechanism is formed from the capsule housing part to the pump.
  • Another valve mechanism is provided to the other side of the pump, and air is supplied to the capsule housing part through the air guide passage having a valve mechanism upon pressing of the pump, and external air is sucked into the pump through the another valve upon removal of the pump pressure.
  • the cylindrical member has, at its top end, a cap fitted to the top end and a needle is extended axially in the cap so as to perforate both axial ends of the capsule by engaging the cap in a state of fitting the concave part of the cylindrical member and the top end having an opening.
  • the capsule after inserting the capsule filled with a powdery medicine into the concave part of the cylindrical member, the capsule is inserted and fixed in the capsule housing portion by fitting the top end. Then a cap is fitted to the top end made of a hard resin to perforate at both axial top ends of the capsule by a needle built inside the cap and guided to the top end.
  • a user detaches the cap from the cylindrical member and inserts the top end into one of the nasal nostril and presses the pump. Then, when the pump is pressed, air from the pump flows through the air guide passage into the capsule to deliver the medicine in the capsule to the nasal cavity of the user. Further, by repeating the operations for both nasal cavities, the medicine is dosed to both of the nasal cavities.
  • the top end is fitted detachably to the cylindrical member and then a cap is detachably provided to the cylindrical member.
  • a cap is detachably provided to the cylindrical member.
  • the user upon dosing of the medicine, the user inserts the top end into the nasal nostril.
  • the top end since the top end is made of a rigid resin, it may be a worry of injuring the nasal nostril upon insertion. Further, since the top end does not smoothly fitted to the shape of the user's nostril, this hinders application of medicine to the nasal cavity making it impossible for efficient dosing.
  • the present invention intends to overcome such problems.
  • the present invention of claim 1 for solving the problems described above comprises a capsule housing/holding part for housing and holding a capsule filled with a powdery medicine, a pump installed in the capsule housing/holding part for supplying dosing air to the capsule housing/holding part, a medicine delivery part with a top end which may be optionally branched into two ways for delivering the medicine in the capsule loaded into the capsule housing/holding part from the pump to the user's nasal cavity by air supplied through an air flow passage formed in the capsule housing/holding part, a capsule setting/detaching part built drawably in the capsule housing/holding part so as to be movable in the lateral direction relative to the axial direction of the capsule for setting and detaching the capsule thereby perforating at both axial ends of the capsule, and cutting blades built laterally relative to the axial direction of the capsule in the capsule housing/holding part for perforating at both axial ends of the capsule.
  • the invention of claim 2 comprises a medicine capturing/collecting part having a specific structure of an air flow passage for capturing and collecting a powdery medicine dropping and flowing backwardly from the capsule after perforation so as not to flow the medicine backwardly and capable of dosing the thus captured and collected powdery medicine by the pump actuation, and a one-way valve the opening pressure of which is controlled by a spring.
  • the invention of claim 3 comprises the nozzle for the medicine spray part constituted with a flexible tube for insertion while conforming the shape of the user's nasal nostril for dosing when the user applies the powdery medicine to the nasal cavity.
  • a capsule is placed in the capsule setting/detaching part built drawably so as to move in the lateral direction relative the axial direction of the capsule in the capsule housing/holding part and cutting blades built laterally to the axial direction of the capsule in the capsule housing/holding part perforate at both axial ends of the capsule.
  • air is supplied from the pump upon dosing and the air flows into the perforated capsule to deliver and dose the medicine in the capsule through the medicine passage in the medicine delivery part from the nozzle to the user's nasal cavity.
  • the medicine capturing/collecting part, and the one-way valve the opening pressure of which is controlled by the spring are built in the air flow passage between the capsule housing/holding part and the pump, they capture and collect the medicine falling and flowing backwardly from the capsule to the pump upon perforation of the capsule and can prevent falling and backward flow to the pump.
  • the one-way valve is opened by the flow under pressure of air from the pump to deliver and dose the captured and collected medicine together with the medicine in the capsule by way of the capsule housing/holding part and the medicine delivery part from the nozzle to the user's nasal cavity.
  • the user inserts the nozzle of the medicine delivery part into the nasal nostril upon dosing the medicine to the nasal cavity. Since the nozzle is made of a flexible tube, it can be inserted conforming the user's nasal nostril.
  • FIG. 1 is a side elevational view illustrating an embodiment of a powdery medicine delivery device according to the present invention.
  • FIG. 2 is a cross sectional view illustrating an embodiment of a powdery medicine delivery device according to the present invention.
  • FIG. 3 is a view showing a state of drawing out a capsule setting/detaching part and placing a capsule therein in FIG. 2 .
  • FIG. 4 is a cross sectional side elevational view showing a state in which cutting blades are cutting a capsule end in the course where the capsule setting/detaching part with the capsule placed therein is inserted into a capsule housing/holding part.
  • FIG. 5 is a cross sectional view showing a state in which the capsule end is cut off by cutting blades, and the medicine in the capsule upon completion of perforation is falling and flowing backwardly to the pump in FIG. 2 .
  • FIG. 6 is a cross sectional view in a state where the medicine in the capsule is under delivery and dosing by pressing the pump.
  • FIG. 7 is a cross sectional view showing another embodiment of a powdery medicine delivery device of the invention.
  • FIG. 1 is a side elevational view of an embodiment of a device to deliver the powdery medicine into the nasal cavity according to the present invention
  • FIG. 2 is a cross sectional side elevational view of a device to deliver the powdery medicine into the nasal cavity shown in the embodiment.
  • a powdery medicine delivery device 10 for nasal cavity comprises, generally, a capsule housing/holding part 30 for housing and holding a capsule K together with a medicine delivery part 20 , a capsule setting/detaching part 40 built drawably in the capsule housing/holding part 40 and a pump 50 built in the air inlet side of the capsule housing/holding part 30 for supplying air to the capsule, and cutting blades 60 a, 60 b situated at both axial ends of the capsule K of the capsule setting/detaching part 40 of the capsule housing/holding part 30 for perforating holes at both axial ends of the capsule K by setting/detaching operation of the capsule setting/detaching part 40 .
  • a medicine passage 21 is built in an upper part (air exit side) with respect to the axial direction of the capsule K of the capsule housing/holding part 30 , and nozzles 22 A and 22 B made of flexible tubes are formed to the top end of the medicine passage 21 .
  • An air flow passage 31 of the capsule housing/holding part 30 axially below the capsule K (air inlet side) includes a medicine capturing/collecting part 32 for capturing and collecting the powdery medicine falling and flowing backwardly from the capsule K, and a one-way valve 30 also preventing falling and backward flowing of the powdery medicine from the capsule K to the pump 50 .
  • the one-way valve 33 is adapted to prevent back flow of air such that it opens when the pressure of air from the pump 50 reaches at or higher than a prescribed pressure and closes the air flow inlet 35 when the pressure of air from the pump 50 is lower than the prescribed pressure.
  • the capsule setting/detaching part 40 has a capsule attaching/detaching recess 41 at a position of attaching or detaching the capsule K, such that it can be set and detached drawably in the lateral direction with respect to the axial direction of the capsule K to the capsule housing/holding part 30 and a drawing end 44 of the capsule setting/detaching part 40 is regulated by the abutment of the detaching end 44 to the protrusion 37 built in the capsule housing/holding part 30 .
  • the inlet end is regulated by the abutment of a setting/detaching protrusion 45 of the capsule setting/detaching part 40 against the abutment face 36 of the capsule housing/holding part 30 .
  • the pump 50 is comprised of a resilient rubber material into a bottomed cylindrical shape having an attaching part 51 , a bottom 52 and a pressing part 53 at the circumferential surface.
  • the attaching part 51 is mounted sealingly to the cylindrical outer circumferential surface of the capsule housing/holding lower part 38 of the capsule housing/holding part 30 , and an air inlet valve 54 is attached to a central portion of the bottom 52 .
  • the air intake valve 54 produced using a resilient rubber material is comprised of an air inlet form 55 and an inlet valve body 56 .
  • the valve is closed when the pump 50 is pressed, while the valve is opened upon restoration of the pump 50 after pressing to supply external air to the pump 50 .
  • the powdery medicine delivery device 10 for nasal cavity according to this embodiment has been constituted as described above.
  • the capsule K is placed in the capsule attaching/detaching concave 41 of the capsule setting/detaching part 40 and the capsule setting/attaching end face 46 of the capsule setting/detaching part 40 is pressed so as to intrude the capsule setting/detaching part 40 into the capsule housing/holding part 30 .
  • the capsule setting/detaching end face 46 of the capsule setting/detaching part 40 is pushed to abut the setting/detaching protrusion 45 against the abutment surface 36 of the capsule housing/holding part 30 , the capsule K that was already perforated with holes at both axial ends pass completely through to the medicine passage 21 of the medicine delivery part 20 and the air flow channel 31 of the capsule housing/holding part 30 to be in a state ready for dosing the medicine.
  • the medicine in the capsule K perforated at both axial ends thereof falls toward to the air flow passage 31 . Since the one-way valve 33 is closed, the medicine is captured and collected in the medicine capturing/collecting part 32 .
  • holes are easily perforated at both axial ends of the capsule K only by the operation of housing the capsule K in the device 10 to deliver the powdery medicine into the nasal cavity and the medicine falling and flowing backwardly after perforation is reliably captured by the one-way valve 33 and the medicine capturing/collecting part 22 .
  • the pressure of air loaded on the one-half way valve 33 increases and, when it reaches to a predetermined pressure, the one-way valve 33 is opened in which air is supplied from the pump 50 through the one-way valve 33 , the medicine capturing/collecting part 32 and the air flow channel 31 to the capsule K.
  • air from the pump 50 flows from the inside of the capsule K through the medicine passage 21 and the nozzles 22 A, 22 B to the nasal cavities of the user.
  • the medicine in the capsule K is agitated by air flowing inside the capsule K and is delivered and dosed together with air to the nasal cavities of the user.
  • the medicine that was captured and collected in the medicine capturing/collecting part 32 upon perforation and exists in the medicine capturing/collecting part 32 and in the air flow passage 31 is delivered by air from the pump 50 , and is delivered and dosed together with the medicine in the capsule K to the nasal cavities of the user.
  • a prescribed amount of the medicine filled in the capsule K can be reliably delivered and dosed to the user's nasal cavities.
  • the pressing part 53 of the pump 50 having the rubber resiliency restores in the direction shown by an arrow R to cause a negative pressure in the pump 50 , so that the intake valve body 56 of the air intake valve 54 is opened by the pressure of the external air and air flows into the pump 50 from the outside by way of the air intake hole 55 to restore the pressing portion of the pump 50 to an original state as shown by chain double-dashed lines.
  • the cutting blades 60 A, 60 B situated laterally at both axial ends of the capsule K to the capsule housing/holding part 30 cut off both axial end portions KA, KB of the capsule K to perforate both axial ends of the capsule K. That is, containment of the capsule K and perforation thereof can be conducted with an extremely simple operation consisting only of the operation of housing the capsule K in the device 10 to deliver the powdery medicine into the nasal cavity.
  • the capsule can be perforated reliably to ready for dosing the medicine.
  • the capsule housing/holding part 30 is comprised of the medicine capturing/collecting part 31 for capturing and collecting the powdery medicine falling and flowing backwardly from the capsule K, and the one-way valve 33 also for preventing the falling and backward flowing of the powdery medicine from the capsule K.
  • the one-way valve 33 is adapted such that it opens when the pressure of air from the pump 50 reaches a predetermined pressure, whereas the air flow inlet 35 is closed by the spring 34 when the pressure of air from the pump 50 is lower than the predetermined pressure thereby reliably preventing backward flow of air or medicine.
  • the medicine captured and collected by the medicine capturing/collecting part 32 of the air flow passage 31 and exists therein upon perforation can be delivered and dosed to the user's nasal cavities together with the medicine in the capsule K when the air pressure in the pump 50 increases above the predetermined pressure to open the one-way valve 33 . Accordingly, since this can overcome the problem that the medicine can not be delivered at an adequate dose by the falling of the medicine to the pump from the capsule after the perforation, or a problem that the pump has to be cleaned as in the prior art, a predetermined amount of the medicine filled in the capsule K can reliably be delivered and dosed to the nasal cavities of the user.
  • the medicine passage 21 is built and nozzles 22 A, 22 B comprising flexible tubes are formed to the top end of the medicine passage 21 and they can be inserted for dosing while conforming the user's nasal nostril upon dosing.
  • nozzles 22 A, 22 B comprising flexible tubes are formed to the top end of the medicine passage 21 and they can be inserted for dosing while conforming the user's nasal nostril upon dosing.
  • FIG. 7 is a cross sectional view of a device to deliver the powdery medicine into the nasal cavity according to another embodiment of the present invention (reference numerals in the drawing have same meanings as those in the previous embodiment).
  • This modified embodiment is different from the previous embodiment only in that the nozzle 22 formed of a flexible tube at the top end of the medicine passage 21 comprises a single nozzle in the medicine delivery part 20 , and operation upon perforation to the capsule K and the operation upon dosing the medicine to the user after perforation are quite identical with those of the previous embodiment.
  • the cutting blades situated laterally to the capsule housing/holding part at both axial ends of the capsule cut off both axial ends of the capsule thereby enabling to perforate at both axial ends of the capsule.
  • the present invention can conduct perforation to the capsule reliably by an extremely simple operation without the capsule perforating operation which tends to be forgotten and with no worry of missing separate members such as a cap having a perforating needle or a top end in the prior art, and can perforate the capsule reliably with an extremely simple operation.
  • the device comprises the air flow passage and the medicine capturing/collecting part having a passage shape for capturing and collecting the medicine dropping and flowing backwardly from the capsule after perforation thereby preventing the medicine from falling into the pump and capable of dosing the captured and collected medicine together with the medicine in the capsule by the operation of the pump, and one-way valve controlled to a predetermined opening pressure by the spring are built between the capsule housing/holding part and the pump, the falling and backwardly flowing medicine upon perforation is delivered and dosed to the nasal cavities of the user together with the medicine in the capsule by way of the capsule housing/holding part and the medicine delivery part, and a predetermined amount of the medicine filled in the capsule can reliably be delivered and dosed to the nasal cavities of the user. Further, since the medicine does not drop at all to the pump, cleaning operation for the pump can be saved.
  • the nozzle of the medicine delivery part is formed of a flexible tubes, it can be inserted smoothly while conforming the shape of the user's nasal nostril upon inserting the nozzle into the nasal nostril by the user, efficient dosing can be conducted safely while being conformed with the shape of the user's nasal nostril.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Otolaryngology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
US12/576,219 2003-03-27 2003-03-27 Powder medicine applicator for nasal cavity Expired - Fee Related USRE45404E1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/576,219 USRE45404E1 (en) 2003-03-27 2003-03-27 Powder medicine applicator for nasal cavity

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/JP2003/003852 WO2004087243A1 (ja) 2003-03-27 2003-03-27 鼻腔用粉末薬剤施薬装置
US10/550,490 US7278982B2 (en) 2003-03-27 2003-03-27 Powder medicine applicator for nasal cavity
US12/576,219 USRE45404E1 (en) 2003-03-27 2003-03-27 Powder medicine applicator for nasal cavity

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US10/550,490 Reissue US7278982B2 (en) 2003-03-27 2003-03-27 Powder medicine applicator for nasal cavity

Publications (1)

Publication Number Publication Date
USRE45404E1 true USRE45404E1 (en) 2015-03-03

Family

ID=33105302

Family Applications (2)

Application Number Title Priority Date Filing Date
US10/550,490 Ceased US7278982B2 (en) 2003-03-27 2003-03-27 Powder medicine applicator for nasal cavity
US12/576,219 Expired - Fee Related USRE45404E1 (en) 2003-03-27 2003-03-27 Powder medicine applicator for nasal cavity

Family Applications Before (1)

Application Number Title Priority Date Filing Date
US10/550,490 Ceased US7278982B2 (en) 2003-03-27 2003-03-27 Powder medicine applicator for nasal cavity

Country Status (8)

Country Link
US (2) US7278982B2 (de)
EP (1) EP1607117A4 (de)
KR (1) KR100974482B1 (de)
CN (1) CN1758930B (de)
AU (1) AU2003220808B2 (de)
CA (1) CA2519287A1 (de)
MX (1) MXPA05010379A (de)
WO (1) WO2004087243A1 (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230090739A1 (en) * 2020-01-27 2023-03-23 Aptar France Sas Device for dispensing a pulverulent product
US11744967B2 (en) 2017-09-26 2023-09-05 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3950738B2 (ja) 2002-05-14 2007-08-01 株式会社 バイオアクティス 鼻腔用粉状薬剤施薬装置
WO2004073729A1 (ja) 2003-02-21 2004-09-02 Translational Research Ltd. 薬物の経鼻投与用組成物
KR100974482B1 (ko) 2003-03-27 2010-08-10 가부시키가이샤 바이오악티스 비강용 분말 약제 투약 장치
JP2007533387A (ja) * 2004-04-21 2007-11-22 イノベータ バイオメド リミテッド 吸入器
US8673360B2 (en) * 2004-08-10 2014-03-18 Shin Nippon Biomedical Laboratories, Ltd. Compositions that enable rapid-acting and highly absorptive intranasal administration
WO2006037636A2 (en) * 2004-10-06 2006-04-13 Boehringer Ingelheim International Gmbh Dispensing device, storage device and method for dispensing powder
DE102006006647B3 (de) * 2006-02-14 2007-01-18 Braunform Gmbh Vorrichtung zum Inhalieren eines in einer Kapsel sich befindenden Pulvers
PT103481B (pt) * 2006-05-16 2008-08-01 Hovione Farmaciencia S A Inalador de uso simples e método de inalação
US7806117B2 (en) * 2006-06-07 2010-10-05 Shin Nippon Biomedical Laboratories, Ltd. Peroral powder delivery device
US8360056B2 (en) * 2006-08-31 2013-01-29 Hitachi, Ltd. Medicine sprayer
FR2909288B1 (fr) * 2006-12-01 2009-02-06 Jose Bensoussan Embout nasal pour dispositif d'aspiration de secretions nasales et dispositif d'aspiration de secretions nasales comprenant cet embout nasal
CN101668544B (zh) * 2006-12-26 2013-04-24 株式会社新日本科学 经鼻投用制剂
EP2373373B1 (de) * 2008-12-15 2013-12-04 ProFibrix BV Pulverabgabevorrichtung
US9101539B2 (en) * 2009-05-15 2015-08-11 Shin Nippon Biomedical Laboratories, Ltd. Intranasal pharmaceutical compositions with improved pharmacokinetics
US8827946B2 (en) * 2009-07-31 2014-09-09 Shin Nippon Biomedical Laboratories, Ltd. Intranasal granisetron and nasal applicator
GB201021881D0 (en) 2010-12-23 2011-02-02 Profibrix Bv Powder delivery device
KR20140003582A (ko) 2011-01-31 2014-01-09 신 니뽄 바이오메디칼 라보라토리즈, 엘티디. 비강내 전달 장치
JP5772030B2 (ja) * 2011-02-08 2015-09-02 ニプロ株式会社 粉体噴射装置
BR112013027779A2 (pt) 2011-04-28 2017-02-21 C Mehta Ketan ponta para enxágue nasal
MY168354A (en) * 2011-07-18 2018-10-31 Rhinosystems Inc Nasal irrigation device and system with faux collapsible cartridge element
JP5840457B2 (ja) * 2011-10-31 2016-01-06 株式会社吉野工業所 点鼻薬噴出器
CN103285503A (zh) * 2013-06-06 2013-09-11 魏永祥 一种粉末药剂喷药瓶
UA115119U (xx) * 2013-12-06 2017-04-10 Ручний іригатор ротової порожнини
JP6549804B2 (ja) * 2016-02-04 2019-07-24 アイ ピー メッド，インコーポレイテッド 薬剤送出装置および方法
JP6726542B2 (ja) * 2016-06-30 2020-07-22 株式会社吉野工業所 粉体吐出器
CN109364359B (zh) * 2018-11-27 2021-03-26 孔静 一种鼻腔喷药装置
IT201900016274A1 (it) * 2019-09-13 2021-03-13 3A Health Care S R L Dispositivo e kit di erogazione di una sostanza nebulizzata
USD971021S1 (en) * 2020-04-22 2022-11-29 Bayer Healthcare Llc Bottle

Citations (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3906950A (en) 1973-04-04 1975-09-23 Isf Spa Inhaling device for powdered medicaments
US4013075A (en) * 1974-07-15 1977-03-22 I.S.F. S.P.A. Inhalers and insufflators having a cutting means
JPS53127553A (en) 1977-04-13 1978-11-07 Asahi Chem Ind Co Ltd Vehicle
JPS5462328A (en) 1977-10-24 1979-05-19 Asahi Chem Ind Co Ltd Additive for cosmetics
US4159345A (en) 1977-04-13 1979-06-26 Fmc Corporation Novel excipient and pharmaceutical composition containing the same
US4226233A (en) * 1978-10-10 1980-10-07 Longevity Products, Inc. Respirators
US4300545A (en) 1980-06-23 1981-11-17 Schering Corporation Method and nozzle for nasal vaccination of immature mammals
JPS5934267A (ja) 1982-08-23 1984-02-24 帝人株式会社 粉状薬剤施薬装置
JPS59163313A (ja) 1983-03-09 1984-09-14 Teijin Ltd 経鼻投与用ペプチドホルモン類組成物
EP0147755A2 (de) 1983-12-17 1985-07-10 Boehringer Ingelheim Kg Inhalator
JPS60224616A (ja) 1984-04-24 1985-11-09 Teijin Ltd 経鼻投与用組成物
JPS6242888A (ja) 1985-08-21 1987-02-24 カシオ計算機株式会社 太陽電池を備えたｉｃカ−ド
JPS63267731A (ja) 1987-04-23 1988-11-04 Asahi Chem Ind Co Ltd 錠剤組成物
JPH0329146A (ja) 1989-06-12 1991-02-07 Grass Valley Group Inc:The スイッチ制御装置
US5098907A (en) 1989-01-24 1992-03-24 Ishihara Sangyo Kaisha Ltd. Powdery pharmaceutical composition containing benzoyl urea, a dispersant and silicic acid
JPH0532560A (ja) 1991-08-01 1993-02-09 Teijin Ltd 安定化されたカルシトニン類医薬組成物
WO1994004133A1 (en) 1992-08-14 1994-03-03 Rhone-Poulenc Rorer Limited Inhalation powder containing antistatic agent
US5320094A (en) 1992-01-10 1994-06-14 The Johns Hopkins University Method of administering insulin
WO1995012399A1 (en) 1993-11-01 1995-05-11 Pharmacia Ab Composition for drug delivery comprising nicotine or a derivative thereof and starch microspheres and method for the manufacturing thereof
US5419315A (en) 1993-01-29 1995-05-30 Aradigm Corporation Intrapulmonary delivery of hormones
JPH07165613A (ja) 1993-10-19 1995-06-27 Dot:Kk 経鼻吸収薬物用キャリヤおよび生理活性ペプチド組成物
WO1995034582A1 (en) 1994-06-16 1995-12-21 Pharmacia S.P.A. Bioadhesive starches and process for their preparation
JPH0898888A (ja) 1994-09-30 1996-04-16 Teijin Ltd 粉末状薬剤噴霧施薬装置
JPH08206208A (ja) 1995-02-06 1996-08-13 Unisia Jecs Corp 鼻腔用投薬器
JPH08243164A (ja) 1995-03-13 1996-09-24 Unisia Jecs Corp 鼻腔用投薬器
EP0761248A1 (de) 1995-03-10 1997-03-12 Unisia Jecs Corporation Verteiler für intranasanale medikamente
US5647349A (en) * 1995-06-01 1997-07-15 Unisia Jecs Corporation Medicine administering inhaling device
WO1997031626A1 (fr) 1996-02-27 1997-09-04 Teijin Limited Composition pulverulente destinee a une adminstration nasale
US5672581A (en) 1993-01-29 1997-09-30 Aradigm Corporation Method of administration of insulin
US5674507A (en) 1992-12-14 1997-10-07 Biocontrol, Inc. Low crystallinity cellulose excipients
JPH09276405A (ja) 1996-04-15 1997-10-28 Unisia Jecs Corp 鼻腔用投薬器
US5683361A (en) * 1991-12-10 1997-11-04 Novo Nordisk A/S Disposable dispenser for powder
JPH09291026A (ja) 1996-02-28 1997-11-11 Teijin Ltd 即効性と持続性を兼ね備えた粉末状経鼻投与用組成物
JPH1059841A (ja) 1996-02-27 1998-03-03 Teijin Ltd 吸収性が改善された粉末状経鼻投与組成物
US5731303A (en) 1985-12-04 1998-03-24 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery compositions
US5756483A (en) 1993-03-26 1998-05-26 Merkus; Franciscus W. H. M. Pharmaceutical compositions for intranasal administration of apomorphine
WO1998030207A1 (en) 1997-01-14 1998-07-16 Danbiosyst Uk Limited Chitosan-gelatin a microparticles
US5810004A (en) * 1995-10-09 1998-09-22 Unisia Jecs Corporation Medicator for a capsule filled with a powdered drug
WO1999016470A1 (fr) 1997-09-30 1999-04-08 Daiichi Pharmaceutical Co., Ltd. Preparation orale
WO1999016422A1 (en) 1997-09-29 1999-04-08 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
JPH11216357A (ja) 1998-02-03 1999-08-10 Tsutsumi Techno Planning Kk 生理活性物質用の吸着担体
US5942242A (en) 1995-07-12 1999-08-24 Ltt Institute Co., Ltd Medicaments for nasal administration
US5948749A (en) 1996-10-07 1999-09-07 Fuji Yakuhin Company, Limited Pharmaceutical preparations for intranasal administration
US5958458A (en) 1994-06-15 1999-09-28 Dumex-Alpharma A/S Pharmaceutical multiple unit particulate formulation in the form of coated cores
WO1999051205A1 (en) 1998-04-03 1999-10-14 University College Cardiff Consultants Limited Aerosol composition
US5989217A (en) 1996-03-21 1999-11-23 Unisia Jecs Corporation Medicine administering device for nasal cavities
JPH11322582A (ja) 1998-05-06 1999-11-24 Dot:Kk 経鼻吸収用鼻粘膜付着・滞留型キャリヤ
WO2000012063A1 (fr) 1998-08-26 2000-03-09 Teijin Limited Compositions en poudre s'administrant par voie nasale
WO2000012136A1 (fr) 1998-08-26 2000-03-09 Teijin Limited Compositions en poudre s'administrant par voie nasale
WO2000023023A1 (en) 1998-10-20 2000-04-27 The University Of North Carolina At Chapel Hill Methods of hydrating mucosal surfaces
WO2000038811A1 (en) 1998-12-24 2000-07-06 Glaxo Group Limited Apparatus and process for preparing crystalline particles
JP2000229859A (ja) 1999-02-12 2000-08-22 Teijin Ltd 安定なブプレノルフィン経鼻製剤
JP2000239187A (ja) 1999-02-22 2000-09-05 Dotto:Kk 経鼻吸収用組成物
US6136295A (en) 1996-05-24 2000-10-24 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
JP2001055323A (ja) 1999-08-12 2001-02-27 Teijin Ltd 粉末状経鼻投与用組成物
US6197328B1 (en) 1999-08-20 2001-03-06 Dott Research Laboratory Nasally administrable compositions
WO2001026630A1 (fr) 1999-10-12 2001-04-19 Kaken Pharmaceutical Co., Ltd. Preparations pour inhalation en poudre et leur procede de production
WO2001032125A2 (en) 1999-11-03 2001-05-10 Glaxo Group Limited Apparatus and process for preparing crystalline particles
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US6273086B1 (en) * 1998-02-06 2001-08-14 Unisia Jecs Corporation Inhalant medicator
US20010027301A1 (en) 1999-10-14 2001-10-04 Steven Lau Controlled-dose dispenser with integral nozzle and cap
US6298846B1 (en) * 1997-01-30 2001-10-09 Unisia Jecs Corporation Suction type medicator
US20010038824A1 (en) 2000-01-20 2001-11-08 Ikuo Horii Intranasal cyclic peptide formulations
US20020002172A1 (en) 1998-05-15 2002-01-03 Cristi L. Bell-Huff Pharmaceutical formulations
US20020040139A1 (en) 1998-06-22 2002-04-04 Anne Billotte Intranasal formulations for treating sexual disorders
WO2002032406A2 (en) 2000-10-18 2002-04-25 Massachusetts Institute Of Technology Methods and products related to pulmonary delivery of polysaccharides
US20020062829A1 (en) 2000-11-27 2002-05-30 Unisia Jecs Corporation Inhalator, a powder composition and a process for administering the powder composition using inhalators
JP2002255795A (ja) 2001-02-26 2002-09-11 Teijin Ltd 経鼻投与用組成物
WO2002094233A1 (en) 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Delivery of antiemetics through an inhalation route
WO2003004048A1 (en) 2001-07-05 2003-01-16 Translational Research Ltd. Compositions for nasal administration of insulin
US6516795B1 (en) * 1997-11-17 2003-02-11 Rexam Sofab Nose sprayer
WO2003030872A2 (en) 2001-10-12 2003-04-17 Elan Pharma International Ltd. Compositions having a combination of particles for immediate release and for controlled release
JP2003154006A (ja) 2001-11-19 2003-05-27 Bioactis:Kk 鼻腔用粉状薬剤施薬装置
JP2003175103A (ja) 2001-12-12 2003-06-24 Teijin Ltd 粉末薬剤多回投与器
JP2003206227A (ja) 2002-01-09 2003-07-22 Ｔｒａｎｓｌａｔｉｏｎａｌ Ｒｅｓｅａｒｃｈ株式会社 薬物の経鼻投与用組成物
WO2003077825A2 (en) 2002-03-12 2003-09-25 Microdose Technologies, Inc. Site specific delivery of co-administered drugs via inhalation
US20030199424A1 (en) 2002-03-20 2003-10-23 Smith Maree Therese Method of treatment and/or prophylaxis
WO2003095008A1 (fr) 2002-05-14 2003-11-20 Bioactis Limited Dispositif d'injection de produit chimique en poudre pour cavite nasale
WO2004004922A1 (en) 2002-07-09 2004-01-15 Optinose As Delivery devices
US20040076588A1 (en) 2002-06-28 2004-04-22 Batycky Richard P. Inhalable epinephrine
US20040092428A1 (en) 2001-11-27 2004-05-13 Hongming Chen Oral pharmaceuticals formulation comprising paclitaxel, derivatives and methods of administration thereof
GB2395900A (en) 2002-12-04 2004-06-09 Elan Drug Delivery Ltd Therapeutic composition for respiratory delivery
WO2004073729A1 (ja) 2003-02-21 2004-09-02 Translational Research Ltd. 薬物の経鼻投与用組成物
EP1454648A1 (de) 2003-03-05 2004-09-08 Hitachi Unisia Automotive Ltd. Vorrichtung zur Verabreichung von Medikamenten in die Nasenhöhle
US20040173211A1 (en) * 2003-01-14 2004-09-09 Boehringer Ingelheim International Gmbh Powder inhaler
US6815424B2 (en) 1987-10-15 2004-11-09 Pfizer Corporation Intranasal administration of polypeptides in powdered form
US6824080B2 (en) 2000-06-12 2004-11-30 Teijin Limited Powdered medicine multi-dose administering device
US20040241232A1 (en) 2001-09-17 2004-12-02 Brown Andrew Bruce Dry powder medicament formulations
US20050022812A1 (en) 2003-06-13 2005-02-03 Advanced Inhalation Research, Inc. Low dose pharmaceutical powders for inhalation
US6855913B2 (en) 2002-08-06 2005-02-15 Hobart Brothers Company Flux-cored wire formulation for welding
WO2005013937A2 (en) 2003-07-23 2005-02-17 Elan Pharma International Ltd. Novel compositions of sildenafil free base
WO2005056008A1 (en) 2003-12-05 2005-06-23 Archimedes Development Limited Intranasal compositions
WO2005104712A2 (en) 2004-04-23 2005-11-10 Cydex, Inc. Dpi formulation containing sulfoalkyl ether cyclodextrin
WO2006016530A1 (ja) 2004-08-10 2006-02-16 Translational Research, Ltd. 速効性でかつ高い吸収性を可能とする経鼻投与用組成物
WO2006040680A1 (en) 2004-10-15 2006-04-20 Pfizer Products Inc. Compositions and methods for intranasal, buccal, sublingual and pulmonary delivery of varenicline
US20060106057A1 (en) 1998-06-05 2006-05-18 Warner-Lambert Company. Llc Stabilization of quinapril using magnesium oxide
US20060116657A1 (en) 2003-03-21 2006-06-01 Daniel Schmid Mixing capsule
US20060216352A1 (en) 2003-01-31 2006-09-28 Orexo Ab Rapid-acting pharmaceutical composition
US20060217658A1 (en) 2003-03-27 2006-09-28 Tatsuo Tsutsui Power medicine applicator for nasal cavity
US7115281B2 (en) 2002-07-08 2006-10-03 Ranbaxy Laboratories Limited Processes for the preparation of oral dosage formulations of modafinil
US20070055200A1 (en) 2005-08-10 2007-03-08 Gilbert Scott J Needle-free jet injection drug delivery device
US20070060868A1 (en) 2003-10-09 2007-03-15 Bioactis Limited Device to deliver a powdery medicine into nasal cavity
US20070065509A1 (en) 2000-06-26 2007-03-22 Bayer Healthcare Aktiengesellschaft Method of preparing sustained-release preparations of quinolone antibiotics
US20070098804A1 (en) 2005-08-29 2007-05-03 Judith Aronhime Solid particulate tadalafil having a bimodal particle size distribution
JP3912469B2 (ja) 1999-05-13 2007-05-09 セイコーエプソン株式会社 偽造印刷物判定用インク
US20070178164A1 (en) 2006-01-31 2007-08-02 Sigal Blau Pharmaceutical formulations of oxcarbazepine and methods for its preparation
US20070184109A1 (en) 2003-06-06 2007-08-09 Floyd Alison G Compositions comprising triptans and nsaids
US20070249674A1 (en) 2006-04-25 2007-10-25 Jennifer Bolton Crystalline forms of a dimethylphenyl compound
US20070272763A1 (en) 2004-10-06 2007-11-29 Boehringer Ingelheim International Gmbh Dispensing Device, Storage Device and Method for Dispensing Powder
US7306787B2 (en) 1997-09-29 2007-12-11 Nektar Therapeutics Engineered particles and methods of use
US20080031959A1 (en) 2006-07-28 2008-02-07 Blondino Frank E Anti-migraine oral spray formulations and methods
US20080029084A1 (en) 2006-08-04 2008-02-07 Nastech Pharmaceutical Company Inc. Device for improved peptide delivery
WO2008031028A2 (en) 2006-09-07 2008-03-13 Parion Sciences, Inc. Methods of enhancing mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes
US20080127972A1 (en) 2004-11-23 2008-06-05 Vectura Limited Dry Powder Inhaler Formulations Comprising Surface-Modified Particles With Anti-Adherent Additives
WO2008075102A1 (en) 2006-12-19 2008-06-26 Pharmakodex Limited Pharmaceutical compositions for transmucusal delivery of a therapeutically active agent on the basis of submicron particles
WO2008078730A1 (ja) 2006-12-26 2008-07-03 Translational Research, Ltd. 経鼻投与用製剤
US20080286362A1 (en) 2005-08-05 2008-11-20 Baran Jr Jimmie R Compositions Exhibiting Improved Flowability
US20090157037A1 (en) 2007-10-12 2009-06-18 Laxmi Iyer Inhalation drug delivery
WO2009095684A1 (en) 2008-02-01 2009-08-06 Vectura Limited Pulmonary formulations of triptans
US7806117B2 (en) 2006-06-07 2010-10-05 Shin Nippon Biomedical Laboratories, Ltd. Peroral powder delivery device
US20110033544A1 (en) 2009-05-15 2011-02-10 Shin Nippon Biomedical Laboratories, Ltd. Intranasal pharmaceutical compositions with improved pharmacokinetcs
US20110045088A1 (en) 2009-07-31 2011-02-24 Shin Nippon Biomedical Laboratories, Ltd. Intranasal granisetron and nasal applicator

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US177095A (en) * 1876-05-09 Improvement in slow-closing compression-cocks
JP2539333Y2 (ja) * 1989-04-03 1997-06-25 オムロン株式会社 吸入器
IT1230313B (it) * 1989-07-07 1991-10-18 Somova Spa Inalatore per medicamenti in capsule.
US5901703A (en) * 1995-02-06 1999-05-11 Unisia Jecs Corporation Medicine administering device for nasal cavities

Patent Citations (150)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3906950A (en) 1973-04-04 1975-09-23 Isf Spa Inhaling device for powdered medicaments
US4013075A (en) * 1974-07-15 1977-03-22 I.S.F. S.P.A. Inhalers and insufflators having a cutting means
JPS53127553A (en) 1977-04-13 1978-11-07 Asahi Chem Ind Co Ltd Vehicle
US4159345A (en) 1977-04-13 1979-06-26 Fmc Corporation Novel excipient and pharmaceutical composition containing the same
JPS5462328A (en) 1977-10-24 1979-05-19 Asahi Chem Ind Co Ltd Additive for cosmetics
US4226233A (en) * 1978-10-10 1980-10-07 Longevity Products, Inc. Respirators
US4300545A (en) 1980-06-23 1981-11-17 Schering Corporation Method and nozzle for nasal vaccination of immature mammals
JPS5934267A (ja) 1982-08-23 1984-02-24 帝人株式会社 粉状薬剤施薬装置
JPS59163313A (ja) 1983-03-09 1984-09-14 Teijin Ltd 経鼻投与用ペプチドホルモン類組成物
EP0122036A1 (de) 1983-03-09 1984-10-17 Teijin Limited Puderförmige pharmazeutische Zusammensetzung zur nasalen Anwendung
US4613500A (en) 1983-03-09 1986-09-23 Teijin Limited Powdery pharmaceutical composition for nasal administration
EP0147755A2 (de) 1983-12-17 1985-07-10 Boehringer Ingelheim Kg Inhalator
JPS60185564A (ja) 1983-12-17 1985-09-21 ベ−リンガ−　インゲルハイム　コマンデイツト　ゲゼルシヤフト 吸入器
US4889114A (en) * 1983-12-17 1989-12-26 Boehringer Ingelheim Kg Powdered pharmaceutical inhaler
JPS60224616A (ja) 1984-04-24 1985-11-09 Teijin Ltd 経鼻投与用組成物
JPS6242888A (ja) 1985-08-21 1987-02-24 カシオ計算機株式会社 太陽電池を備えたｉｃカ−ド
US5731303A (en) 1985-12-04 1998-03-24 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery compositions
JPS63267731A (ja) 1987-04-23 1988-11-04 Asahi Chem Ind Co Ltd 錠剤組成物
US6815424B2 (en) 1987-10-15 2004-11-09 Pfizer Corporation Intranasal administration of polypeptides in powdered form
US5098907A (en) 1989-01-24 1992-03-24 Ishihara Sangyo Kaisha Ltd. Powdery pharmaceutical composition containing benzoyl urea, a dispersant and silicic acid
JPH0329146A (ja) 1989-06-12 1991-02-07 Grass Valley Group Inc:The スイッチ制御装置
JPH0532560A (ja) 1991-08-01 1993-02-09 Teijin Ltd 安定化されたカルシトニン類医薬組成物
US5683361A (en) * 1991-12-10 1997-11-04 Novo Nordisk A/S Disposable dispenser for powder
US5320094A (en) 1992-01-10 1994-06-14 The Johns Hopkins University Method of administering insulin
WO1994004133A1 (en) 1992-08-14 1994-03-03 Rhone-Poulenc Rorer Limited Inhalation powder containing antistatic agent
US5674507A (en) 1992-12-14 1997-10-07 Biocontrol, Inc. Low crystallinity cellulose excipients
US5419315A (en) 1993-01-29 1995-05-30 Aradigm Corporation Intrapulmonary delivery of hormones
US5672581A (en) 1993-01-29 1997-09-30 Aradigm Corporation Method of administration of insulin
US5756483A (en) 1993-03-26 1998-05-26 Merkus; Franciscus W. H. M. Pharmaceutical compositions for intranasal administration of apomorphine
JPH07165613A (ja) 1993-10-19 1995-06-27 Dot:Kk 経鼻吸収薬物用キャリヤおよび生理活性ペプチド組成物
US5939100A (en) 1993-11-01 1999-08-17 Pharmacia And Upjohn Ab Composition for drug delivery comprising nicotine or a derivative thereof and starch microspheres and method for the manufacturing thereof
WO1995012399A1 (en) 1993-11-01 1995-05-11 Pharmacia Ab Composition for drug delivery comprising nicotine or a derivative thereof and starch microspheres and method for the manufacturing thereof
US5958458A (en) 1994-06-15 1999-09-28 Dumex-Alpharma A/S Pharmaceutical multiple unit particulate formulation in the form of coated cores
WO1995034582A1 (en) 1994-06-16 1995-12-21 Pharmacia S.P.A. Bioadhesive starches and process for their preparation
US5804209A (en) 1994-06-16 1998-09-08 Pharmacia S.P.A. Bioadhesive starches and process for their preparation
JPH0898888A (ja) 1994-09-30 1996-04-16 Teijin Ltd 粉末状薬剤噴霧施薬装置
JPH08206208A (ja) 1995-02-06 1996-08-13 Unisia Jecs Corp 鼻腔用投薬器
EP0761248A1 (de) 1995-03-10 1997-03-12 Unisia Jecs Corporation Verteiler für intranasanale medikamente
JPH08243164A (ja) 1995-03-13 1996-09-24 Unisia Jecs Corp 鼻腔用投薬器
US5647349A (en) * 1995-06-01 1997-07-15 Unisia Jecs Corporation Medicine administering inhaling device
US5942242A (en) 1995-07-12 1999-08-24 Ltt Institute Co., Ltd Medicaments for nasal administration
US5810004A (en) * 1995-10-09 1998-09-22 Unisia Jecs Corporation Medicator for a capsule filled with a powdered drug
JPH1059841A (ja) 1996-02-27 1998-03-03 Teijin Ltd 吸収性が改善された粉末状経鼻投与組成物
WO1997031626A1 (fr) 1996-02-27 1997-09-04 Teijin Limited Composition pulverulente destinee a une adminstration nasale
US20020012688A1 (en) 1996-02-27 2002-01-31 Masahiko Dohi Powdery composition for nasal administration
EP0943326A1 (de) 1996-02-27 1999-09-22 Teijin Limited Puderförmige zusammensetzung zur nasalen anwendung
JPH09291026A (ja) 1996-02-28 1997-11-11 Teijin Ltd 即効性と持続性を兼ね備えた粉末状経鼻投与用組成物
US5989217A (en) 1996-03-21 1999-11-23 Unisia Jecs Corporation Medicine administering device for nasal cavities
JPH09276405A (ja) 1996-04-15 1997-10-28 Unisia Jecs Corp 鼻腔用投薬器
US6136295A (en) 1996-05-24 2000-10-24 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US5948749A (en) 1996-10-07 1999-09-07 Fuji Yakuhin Company, Limited Pharmaceutical preparations for intranasal administration
WO1998030207A1 (en) 1997-01-14 1998-07-16 Danbiosyst Uk Limited Chitosan-gelatin a microparticles
US6298846B1 (en) * 1997-01-30 2001-10-09 Unisia Jecs Corporation Suction type medicator
US7306787B2 (en) 1997-09-29 2007-12-11 Nektar Therapeutics Engineered particles and methods of use
WO1999016422A1 (en) 1997-09-29 1999-04-08 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
WO1999016470A1 (fr) 1997-09-30 1999-04-08 Daiichi Pharmaceutical Co., Ltd. Preparation orale
US6516795B1 (en) * 1997-11-17 2003-02-11 Rexam Sofab Nose sprayer
JPH11216357A (ja) 1998-02-03 1999-08-10 Tsutsumi Techno Planning Kk 生理活性物質用の吸着担体
US6273086B1 (en) * 1998-02-06 2001-08-14 Unisia Jecs Corporation Inhalant medicator
WO1999051205A1 (en) 1998-04-03 1999-10-14 University College Cardiff Consultants Limited Aerosol composition
JPH11322582A (ja) 1998-05-06 1999-11-24 Dot:Kk 経鼻吸収用鼻粘膜付着・滞留型キャリヤ
US20020002172A1 (en) 1998-05-15 2002-01-03 Cristi L. Bell-Huff Pharmaceutical formulations
US20060106057A1 (en) 1998-06-05 2006-05-18 Warner-Lambert Company. Llc Stabilization of quinapril using magnesium oxide
US20020040139A1 (en) 1998-06-22 2002-04-04 Anne Billotte Intranasal formulations for treating sexual disorders
US6835389B1 (en) 1998-08-26 2004-12-28 Teijin Limited Powder Composition for nasal administration
WO2000012136A1 (fr) 1998-08-26 2000-03-09 Teijin Limited Compositions en poudre s'administrant par voie nasale
EP1108423A1 (de) 1998-08-26 2001-06-20 Teijin Limited Pulverförmige pernasale mittel
WO2000012063A1 (fr) 1998-08-26 2000-03-09 Teijin Limited Compositions en poudre s'administrant par voie nasale
EP1025859A1 (de) 1998-08-26 2000-08-09 Teijin Limited Pulverförmige pernasale mittel
WO2000023023A1 (en) 1998-10-20 2000-04-27 The University Of North Carolina At Chapel Hill Methods of hydrating mucosal surfaces
WO2000038811A1 (en) 1998-12-24 2000-07-06 Glaxo Group Limited Apparatus and process for preparing crystalline particles
JP2000229859A (ja) 1999-02-12 2000-08-22 Teijin Ltd 安定なブプレノルフィン経鼻製剤
JP2000239187A (ja) 1999-02-22 2000-09-05 Dotto:Kk 経鼻吸収用組成物
JP3912469B2 (ja) 1999-05-13 2007-05-09 セイコーエプソン株式会社 偽造印刷物判定用インク
JP2001055323A (ja) 1999-08-12 2001-02-27 Teijin Ltd 粉末状経鼻投与用組成物
US6197328B1 (en) 1999-08-20 2001-03-06 Dott Research Laboratory Nasally administrable compositions
WO2001026630A1 (fr) 1999-10-12 2001-04-19 Kaken Pharmaceutical Co., Ltd. Preparations pour inhalation en poudre et leur procede de production
US20010027301A1 (en) 1999-10-14 2001-10-04 Steven Lau Controlled-dose dispenser with integral nozzle and cap
WO2001032125A2 (en) 1999-11-03 2001-05-10 Glaxo Group Limited Apparatus and process for preparing crystalline particles
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US20010038824A1 (en) 2000-01-20 2001-11-08 Ikuo Horii Intranasal cyclic peptide formulations
US6824080B2 (en) 2000-06-12 2004-11-30 Teijin Limited Powdered medicine multi-dose administering device
US20070065509A1 (en) 2000-06-26 2007-03-22 Bayer Healthcare Aktiengesellschaft Method of preparing sustained-release preparations of quinolone antibiotics
WO2002032406A2 (en) 2000-10-18 2002-04-25 Massachusetts Institute Of Technology Methods and products related to pulmonary delivery of polysaccharides
US20020062829A1 (en) 2000-11-27 2002-05-30 Unisia Jecs Corporation Inhalator, a powder composition and a process for administering the powder composition using inhalators
JP2002255795A (ja) 2001-02-26 2002-09-11 Teijin Ltd 経鼻投与用組成物
WO2002094233A1 (en) 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Delivery of antiemetics through an inhalation route
US6906027B2 (en) 2001-07-05 2005-06-14 Translational Research Ltd. Composition for nasal administration of insulin
US20040063615A1 (en) 2001-07-05 2004-04-01 Toshikazu Oki Composition for nasal administration of insulin
WO2003004048A1 (en) 2001-07-05 2003-01-16 Translational Research Ltd. Compositions for nasal administration of insulin
US20040241232A1 (en) 2001-09-17 2004-12-02 Brown Andrew Bruce Dry powder medicament formulations
WO2003030872A2 (en) 2001-10-12 2003-04-17 Elan Pharma International Ltd. Compositions having a combination of particles for immediate release and for controlled release
JP2003154006A (ja) 2001-11-19 2003-05-27 Bioactis:Kk 鼻腔用粉状薬剤施薬装置
US20040092428A1 (en) 2001-11-27 2004-05-13 Hongming Chen Oral pharmaceuticals formulation comprising paclitaxel, derivatives and methods of administration thereof
JP2003175103A (ja) 2001-12-12 2003-06-24 Teijin Ltd 粉末薬剤多回投与器
JP2003206227A (ja) 2002-01-09 2003-07-22 Ｔｒａｎｓｌａｔｉｏｎａｌ Ｒｅｓｅａｒｃｈ株式会社 薬物の経鼻投与用組成物
WO2003077825A2 (en) 2002-03-12 2003-09-25 Microdose Technologies, Inc. Site specific delivery of co-administered drugs via inhalation
US20030199424A1 (en) 2002-03-20 2003-10-23 Smith Maree Therese Method of treatment and/or prophylaxis
WO2003095008A1 (fr) 2002-05-14 2003-11-20 Bioactis Limited Dispositif d'injection de produit chimique en poudre pour cavite nasale
US7353823B2 (en) 2002-05-14 2008-04-08 Bioactis Limited Powder chemical feeding device for nasal cavity
EP1504780A1 (de) 2002-05-14 2005-02-09 Bioactis Limited Vorrichtung zur zufuhr eines pulverförmigen chemischen mittels in die nasenhöhle
US20050177095A1 (en) 2002-05-14 2005-08-11 Tatsuo Tsutsui Powder chemical feeding device for nasal cavity
US20040076588A1 (en) 2002-06-28 2004-04-22 Batycky Richard P. Inhalable epinephrine
US7115281B2 (en) 2002-07-08 2006-10-03 Ranbaxy Laboratories Limited Processes for the preparation of oral dosage formulations of modafinil
WO2004004922A1 (en) 2002-07-09 2004-01-15 Optinose As Delivery devices
US6855913B2 (en) 2002-08-06 2005-02-15 Hobart Brothers Company Flux-cored wire formulation for welding
GB2395900A (en) 2002-12-04 2004-06-09 Elan Drug Delivery Ltd Therapeutic composition for respiratory delivery
US20040173211A1 (en) * 2003-01-14 2004-09-09 Boehringer Ingelheim International Gmbh Powder inhaler
US20060216352A1 (en) 2003-01-31 2006-09-28 Orexo Ab Rapid-acting pharmaceutical composition
US20060233715A1 (en) 2003-02-21 2006-10-19 Toshikazu Oki Compositions for nasal administration of drug
WO2004073729A1 (ja) 2003-02-21 2004-09-02 Translational Research Ltd. 薬物の経鼻投与用組成物
US7638138B2 (en) 2003-02-21 2009-12-29 Translational Research, Ltd. Compositions for nasal administration of pharmaceuticals
US20130287852A1 (en) 2003-02-21 2013-10-31 Shin Nippon Biomedical Laboratories, Ltd. Compositions for nasal administration of pharmaceuticals
US20090169640A1 (en) 2003-02-21 2009-07-02 Translational Research, Ltd. Compositons for nasal administration of pharmaceuticals
EP1454648A1 (de) 2003-03-05 2004-09-08 Hitachi Unisia Automotive Ltd. Vorrichtung zur Verabreichung von Medikamenten in die Nasenhöhle
US20060116657A1 (en) 2003-03-21 2006-06-01 Daniel Schmid Mixing capsule
US20060217658A1 (en) 2003-03-27 2006-09-28 Tatsuo Tsutsui Power medicine applicator for nasal cavity
US7278982B2 (en) 2003-03-27 2007-10-09 Bioactis Limited Powder medicine applicator for nasal cavity
US20070184109A1 (en) 2003-06-06 2007-08-09 Floyd Alison G Compositions comprising triptans and nsaids
US20050022812A1 (en) 2003-06-13 2005-02-03 Advanced Inhalation Research, Inc. Low dose pharmaceutical powders for inhalation
WO2005013937A2 (en) 2003-07-23 2005-02-17 Elan Pharma International Ltd. Novel compositions of sildenafil free base
US20050042177A1 (en) 2003-07-23 2005-02-24 Elan Pharma International Ltd. Novel compositions of sildenafil free base
US20070060868A1 (en) 2003-10-09 2007-03-15 Bioactis Limited Device to deliver a powdery medicine into nasal cavity
WO2005056008A1 (en) 2003-12-05 2005-06-23 Archimedes Development Limited Intranasal compositions
US20050142073A1 (en) 2003-12-05 2005-06-30 West Pharmaceutical Services Drug Delivery & Clinical Research Centre Ltd. Intranasal compositions
WO2005104712A2 (en) 2004-04-23 2005-11-10 Cydex, Inc. Dpi formulation containing sulfoalkyl ether cyclodextrin
EP1785145A1 (de) 2004-08-10 2007-05-16 Translational Research, Ltd. Transnasale zusammensetzung mit sofortiger wirkung und hoher resorbierbarkeit
US20080260848A1 (en) 2004-08-10 2008-10-23 Translational Research, Ltd., Compositions that Enable Rapid-Acting and Highly Absorptive Intranasal Administration
WO2006016530A1 (ja) 2004-08-10 2006-02-16 Translational Research, Ltd. 速効性でかつ高い吸収性を可能とする経鼻投与用組成物
US20070272763A1 (en) 2004-10-06 2007-11-29 Boehringer Ingelheim International Gmbh Dispensing Device, Storage Device and Method for Dispensing Powder
WO2006040680A1 (en) 2004-10-15 2006-04-20 Pfizer Products Inc. Compositions and methods for intranasal, buccal, sublingual and pulmonary delivery of varenicline
US20080127972A1 (en) 2004-11-23 2008-06-05 Vectura Limited Dry Powder Inhaler Formulations Comprising Surface-Modified Particles With Anti-Adherent Additives
US20080286362A1 (en) 2005-08-05 2008-11-20 Baran Jr Jimmie R Compositions Exhibiting Improved Flowability
US20070055200A1 (en) 2005-08-10 2007-03-08 Gilbert Scott J Needle-free jet injection drug delivery device
US20070098804A1 (en) 2005-08-29 2007-05-03 Judith Aronhime Solid particulate tadalafil having a bimodal particle size distribution
US20070178164A1 (en) 2006-01-31 2007-08-02 Sigal Blau Pharmaceutical formulations of oxcarbazepine and methods for its preparation
US20070249674A1 (en) 2006-04-25 2007-10-25 Jennifer Bolton Crystalline forms of a dimethylphenyl compound
US7806117B2 (en) 2006-06-07 2010-10-05 Shin Nippon Biomedical Laboratories, Ltd. Peroral powder delivery device
US20080031959A1 (en) 2006-07-28 2008-02-07 Blondino Frank E Anti-migraine oral spray formulations and methods
US20080029084A1 (en) 2006-08-04 2008-02-07 Nastech Pharmaceutical Company Inc. Device for improved peptide delivery
WO2008031028A3 (en) 2006-09-07 2008-11-13 Parion Sciences Inc Methods of enhancing mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes
US20080090841A1 (en) 2006-09-07 2008-04-17 Parion Sciences, Inc. Methods of enhancing mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes
WO2008031028A2 (en) 2006-09-07 2008-03-13 Parion Sciences, Inc. Methods of enhancing mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes
WO2008075102A1 (en) 2006-12-19 2008-06-26 Pharmakodex Limited Pharmaceutical compositions for transmucusal delivery of a therapeutically active agent on the basis of submicron particles
WO2008078730A1 (ja) 2006-12-26 2008-07-03 Translational Research, Ltd. 経鼻投与用製剤
US20100178331A1 (en) 2006-12-26 2010-07-15 Ryoichi Nagata Preparation for transnasal application
US20090157037A1 (en) 2007-10-12 2009-06-18 Laxmi Iyer Inhalation drug delivery
WO2009095684A1 (en) 2008-02-01 2009-08-06 Vectura Limited Pulmonary formulations of triptans
US20110033544A1 (en) 2009-05-15 2011-02-10 Shin Nippon Biomedical Laboratories, Ltd. Intranasal pharmaceutical compositions with improved pharmacokinetcs
US20110045088A1 (en) 2009-07-31 2011-02-24 Shin Nippon Biomedical Laboratories, Ltd. Intranasal granisetron and nasal applicator

Non-Patent Citations (48)

* Cited by examiner, † Cited by third party
Title
"Fluorouracil" definition viewed on the National Cancer Institute website at www.cancergov/drugdictionary?cdrid=43130 on May 31, 2012.
Advisory action dated Sep. 13, 2013 for U.S Appl. No. 12/848,850.
Component definition, Dictionary.com, accessed Apr. 1, 2014, pp. 1-4.
English Language Abstract of JP 8-098888.
English Language Abstract of JP 9-276405.
European search report and opinion dated Dec. 19, 2011 for Application No. 07860016.0.
European search report and opinion mailed Dec. 20, 2013 for Application No. 10774745.3.
European search report dated Jul. 15, 2008 for Application No. 05768543.0.
Hens, et al., "BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction," Development 2007, 234, pp. 1221-1230.
Hibberd, et al. Immunization strategies for the immunocompromised host: the need for immunoadjuvants. Ann Intern Med. Jun. 15, 1989;110(12):955-6.
International search report (partial) dated Dec. 21, 2010 for PCT Application No. IB2010/02168.
International search report and written opinion dated Jun. 28, 2011 for PCT Application No. IB2010/02168.
International search report dated Feb. 5, 2008 for PCT Application No. JP2007/074787.
International search report dated May 7, 2003 for PCT Application No. JP2003/001948.
International search report dated Nov. 1, 2005 for PCT Application No. JP2005/014389.
International search report Jun. 8, 2010 for PCT Application No. JP2010/003285.
Ishikawa, et al. Improved nasal bioavailability of elcatonin by insoluble powder formulation. Int J Pharm. Aug. 14, 2001;224(1-2):105-14.
Kleinebudde, et al. Influence of degree of polymerization on behavior of cellulose during homogenization and extrusion/spheronization. AAPS Pharmasci 2000, 2(2) Article 21, 1-10.
Labiris, et al. Pulmonary drug delivery. Part I: physiological factors affecting therapeutic effectiveness of aerosolized medications. Br J Clin Pharmacol. Dec. 2003;56(6):588-99.
Merriam-Webster's Collegiate Dictionary, 10th edition, Merriam-Webster Incorporated: Springfield, Massachusetts, 1993, pp. 41.
Office action dated Apr. 20, 2012 for U.S. Appl. No. 12/780,433.
Office action dated Apr. 8, 2014 for U.S. Appl. No. 13/827,859.
Office action dated Apr. 9, 2014 for U.S. Appl. No. 12/780,433.
Office action dated Dec. 5, 2011 for U.S. Appl. No. 12/346,537.
Office action dated Jan. 13, 2011 for U.S. Appl. No. 12/346,537.
Office action dated Jan. 29, 2008 for U.S. Appl. No. 10/545,764.
Office action dated Jun. 25, 2012 for U.S. Appl. No. 12/346,537.
Office action dated Jun. 4, 2012 for U.S. Appl. No. 12/521,116.
Office action dated Mar. 4, 2013 for U.S. Appl. No. 12/848,850.
Office action dated May 7, 2013 for U.S. Appl. No. 11/660,131.
Office action dated Nov. 1, 2012 for U.S. Appl. No. 11/660,131.
Office action dated Oct. 10, 2012 for U.S. Appl. No. 12/780,433.
Office action dated Oct. 15, 2012 for U.S. Appl. No. 12/848,850.
Office action dated Oct. 29, 2009 for U.S. Appl. No. 11/660,131.
Office action dated Sep. 20, 2013 for U.S. Appl. No. 13/827,859.
Office action dated Sep. 24, 2008 for U.S. Appl. No. 10/545,764.
Office action dated Sep. 27, 2010 for U.S. Appl. No. 11/660,131.
Office action dated Sep. 28, 2011 for JP Application No. 2006-531575 (in Japanese with English translation).
Office action dated Sep. 6, 2011 for U.S. Appl. No. 12/346,537.
Partial English Language Translation of JP 3-29146.
Partial English Language Translation of JP 59-34267.
Partition Coefficient, Wikipedia, accessed Mar. 31, 2014, pp. 1-8.
Rowe, et al (Eds). Handbook of Pharmaceutical Excipients. Pharmaceutical Press. 2003. pp. 108-109.
Topliss, John. Quantitative Structure-Activity Relationships of Drugs, 1983, pp. 2.
U.S. Appl. No. 10/512,857, in the name of Tatsu Tsuisui, filed May 13, 2003.
U.S. Appl. No. 13/649,515, filed Oct. 11, 2012, Nagata et al.
UK combined office action and search report dated Nov. 10, 2010 for Application No. GB1012959.1.
UK search report dated Sep. 9, 2011 for Application No. GB1012959.1.

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11744967B2 (en) 2017-09-26 2023-09-05 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices
US12102754B2 (en) 2017-09-26 2024-10-01 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices
US20230090739A1 (en) * 2020-01-27 2023-03-23 Aptar France Sas Device for dispensing a pulverulent product
US12233243B2 (en) * 2020-01-27 2025-02-25 Aptar France Sas Device for dispensing a pulverulent product

Also Published As

Publication number Publication date
EP1607117A1 (de) 2005-12-21
AU2003220808A1 (en) 2004-10-25
MXPA05010379A (es) 2006-05-31
CN1758930B (zh) 2010-06-09
CA2519287A1 (en) 2004-10-14
KR100974482B1 (ko) 2010-08-10
WO2004087243A1 (ja) 2004-10-14
US7278982B2 (en) 2007-10-09
CN1758930A (zh) 2006-04-12
US20060217658A1 (en) 2006-09-28
AU2003220808B2 (en) 2008-08-21
EP1607117A4 (de) 2007-10-24
KR20050110700A (ko) 2005-11-23

Similar Documents

Publication Publication Date Title
USRE45404E1 (en) Powder medicine applicator for nasal cavity
US7353823B2 (en) Powder chemical feeding device for nasal cavity
FI92978B (fi) Inhalaattori lääkeaineen annostelemiseksi kapseliin esiannostetun jauheen muodossa
KR0177354B1 (ko) 분말 약제 충전 캡슐용 투약기
EP1671667A1 (de) Abgabevorrichtung für ein pulverförmiges medikament für die nasenhöhle
KR101745445B1 (ko) 가압형 약물 주입 시스템
BG65349B1 (bg) Устройство за аерозолиране на прахообразен медикамент и метод за използването му
EP3682922B1 (de) Medikamentenspeicherkartusche mit düse, zerstäuber dafür und vorrichtung zur ausgabe von pulverförmigen medikamenten für die nasenhöhle
EA007403B1 (ru) Устройство для выдачи жидкостей, используемый в нём сменный баллончик и система, состоящая из устройства для выдачи жидкостей и сменного баллончика
JP3975327B2 (ja) 鼻腔用粉状薬剤施薬装置
TWI286944B (en) A device for applying medicine powder to nose
RU2324502C2 (ru) Медицинский инструмент для введения порошкообразного лекарственного препарата в полость носа
JP2004129823A (ja) 鼻腔用粉状薬剤施薬装置
CZ20004499A3 (cs) Zařízení pro rozprašování suchého prášku a způsob jeho použit

Legal Events

Date Code Title Description
FPAY Fee payment

Year of fee payment: 8

CC Certificate of correction
FEPP Fee payment procedure

Free format text: MAINTENANCE FEE REMINDER MAILED (ORIGINAL EVENT CODE: REM.); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY

LAPS Lapse for failure to pay maintenance fees

Free format text: PATENT EXPIRED FOR FAILURE TO PAY MAINTENANCE FEES (ORIGINAL EVENT CODE: EXP.); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY