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US3786985A - Blood collection container - Google Patents

Blood collection container Download PDF

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Publication number
US3786985A
US3786985A US00321430A US3786985DA US3786985A US 3786985 A US3786985 A US 3786985A US 00321430 A US00321430 A US 00321430A US 3786985D A US3786985D A US 3786985DA US 3786985 A US3786985 A US 3786985A
Authority
US
United States
Prior art keywords
container
reduced portion
blood
closure means
blood sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US00321430A
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English (en)
Inventor
M Blaivas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoffmann La Roche Inc
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of US3786985A publication Critical patent/US3786985A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150351—Caps, stoppers or lids for sealing or closing a blood collection vessel or container, e.g. a test-tube or syringe barrel
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5021—Test tubes specially adapted for centrifugation purposes

Definitions

  • the invention relates to an improved container for collecting, stabilizing and storing for long periods of time a blood specimen and methods therefor. More particularly, the present invention relates to a new and improved vacuum container for collecting and stabilizing blood which comprises a container member having one end which may be integrally closed and the other end closed by a plug, a reduced portion disposed between the longitudinal ends of said container member and a closure means disposed therein and adopted under the influence of centrifugal force to be securely received in the reduced portion.
  • Vacuum-type containers for collecting blood specimens are well known in the art.
  • such containers comprise a hollow tubular member provided with a hypodermic needle which is inserted directly or via a cannula into the container.
  • the blood so-obtained, after appropriate treatment and separation, is tested for physiologically significant indications.
  • the blood sample may be treated with an anticoagulant and centrifuged whereby the plasma is separated from the particulate matter, i.e. red and white cells and platelets and, thereafter, the plasma can be analyzed utilizing appropriate biochemical and serological tests.
  • the blood sample may be allowed to clot without prior treatment and then centrifuged whereby the serum is separated from the particulate matter, and thereafter the serum can be analyzed utilizing biochemical and serological tests.
  • the liquid portion of the blood that is, the plasma or serum
  • prior art devices do function efficaciously to obtain blood samples, they require that the collected sample be promptly analyzed due to the fact that upon standing blood deteriorates, i.e. its constituents interact and thereby causes inaccurate analysis. Thus, prior art devices suffer from the defect of lacking means for preventing blood deterioration from occurring, that is, means which insure stabilization, if the blood sample is permitted to stand for extended periods of time.
  • an evacuated tubular container made of suitable material
  • a deformable member positioned in the container is moved under the influence of a higher centrifugal force to a position whereby it is securely received in said tapered position. In this position, the deformable member is positioned between the portions of the container which contains, respectively, the plasma or serum and the particulate matter. In this manner, the plasma or serum remain separated and contact with the particulate matter is avoided.
  • the centrifugal force required to move the deformable member and to separate the plasma or the serum from the particulate matter is provided by any conventional centrifuge.
  • Physicians, laboratory technicians and the like use centrifuges to spin or whirl containers or vessels containing blood sample to subject the sample to centrifugal force.
  • Such devices usually consist of a rotor adopted to spin about a horizontal plane.
  • the machine is equipped with a series of elongated recepticles pivotally mounted near the open ends so as to depend vertically when the rotor is at its rest position.
  • the lower portions of the recepticles are adopted to swing outwardly and upwardly to bring the recepticles substantially radially upon rotation of the rotor.
  • the recepticles of the centrifugal machine are loaded with the sample containing vessels by dropping the latter therein while the recepticles rest in depending positions.
  • Such centrifugal devices can be activated so that the rotor can rotate at varying speeds. As should be evident, such machines are well known in the art.
  • FIG. 1 is a side view with parts in cross section of an apparatus embodying the invention before use;
  • FIG. 2 is a side view with parts in cross section of an apparatus embodying the invention showing transition of the closure means with respect to the reduced poron of h ssn riqa-.-
  • FIG. 3 is a side view in cross section of an embodiment of the closure means of the apparatus of the inn i no a- FIG. 4 is a side view with parts in cross section of an apparatus embodying the invention after use; an d FIG. 5 is a side view with parts in cross section of another apparatus embodying the invention before use.
  • a tubular member, vessel or container formed from any suitable material, preferably, glass or plastic, is provided with an open end 11 and a reduced intermediate section 17.
  • a stopper 13 is removably received in the open end 1 1.
  • the stopper 13 is made of rubber or any other suitable composition.
  • the stopper 13 may be provided with a needle means not shown.
  • the tubular member 10 is evacuated so that upon release of the vacuum, blood from a patient can be drawn into the tubular member in accordance with conventional techniques. Evacuation may be effected by passing an evacuating means through the stopper l3 and closure means 30 which evacuating means isconnccted to an evacuating mechanism.
  • the tubular member, vessel or container 10 comprises two sections 20 and 21 and a reduced portion 17 which are integrally connected.
  • Section 20 extends from end 11 which is closed by stopper 13 to the reduced portion 17.
  • Section 20 includes a tapered portion 23.
  • Section 21 extends from closed end 25 to the reduced portion 17 and includes tapered portion 24.
  • the reduced portion 17 is positioned at the juncture of tapered portions 23 and 24.
  • theopening defined by reduced portion 17 and by the inner walls of tapered portion 23 and 24 is of a diameter which is less than the diameter of the opening defined by the longitudinal walls of the vessel 10 which are not tapered.
  • the longitudinal walls of section 20 are tapered so that the diameter of the opening defined by the upper end of section 20' opposite to closure member 30 is smaller than the diameter of the opening defined by the lower end of section 20' nearer to reduced portion 17, and the opening defined by reduced portion 17 and by the inner walls of tapered portions 23 and 24 are of a diameter which is less than the diameter of the opening defined by the upper end of section 20' opposite closure member 30.
  • closure means 30 which may be of rubber, plastic or other suitable elastomeric deformable material.
  • the closure means 30 comprises a tapered body portion 31 which centrally defines a diaphragm 32.
  • the contiguous outer wall of said tapered body portion is adapted to engage the upper end of the inner surface of section 20 below stopper 13.
  • the tapered body portion 31 of closure means 30 should be so sized that the upper portion thereof 34 will bear against the adjacent inner wall of vessel 10 and not move toward the reduced portion 17 under normal conditions or under the influence of a centrifugal force which will cause separation of the plasma or the serum from the particulate matter.
  • a deformable tapered portion 33 Extending downwardly from diaphragm 32 is a deformable tapered portion 33. When in deformed condition, the configuration of tapered portion 33 conforms to the tapered portion 23 of section 20.
  • container 10 should be constructed so that preferably the total volume contained within section 20 is approximately 40 percent of the total volume contained within the entire tube. Hence, the volume contained within section 21 is approximately 60 percent of the total volume contained in the entire tube.
  • blood is collected in the evacuated container according to conventional procedures, by puncturing simultaneously the stopper 13 and the diaphragm 32 of closure means 30.
  • the container is then placed on a centrifuge of conventional design.
  • the serum or plasma is separated from the particulate matter with the serum or plasma being received in section 20 and particulate matter being received in section 21.
  • the speed of the centrifuge is increased, preferably to about twice the speed employed to separate the plasma or the serum, however, speeds from about 2,500 RPM to about 4,000 RPM should be sufficient. As shown in FIG.
  • the tapered end 33 of the closure means 30 is driven toward the reduced orifice 17 under the influence of the increased centrifugal force until it is wedged into tapered portion 23 as seen in FIG. 4.
  • the plasma or the serum is permanently separated from the particulate and cross-reaction of one with the'other is precluded.
  • the device in FIG. 2 is shown as being under the influence of an increased centrifugal speed. At this speed, the closure means 30 has begun its downward path toward the tapered portion 17. Under the influence of the increased centrifugal force, as depicted by the downwardly extending arrow in FIG. 2, the closure means 30 is deformed thereby permitting fluid to pass between its sides and the inner walls of section 20, as represented by the upwardly directioned arrows.
  • the blood can be stored for long periods of time without degradation or biochemical changes occurring.
  • the device or apparatus of the present invention provides a simple means for withdrawing, collecting, stabilizing, and transmitting blood samples without the necessity of utilizing separate devices. In this manner, the aseptic transfer of blood is accomplished in one apparatus without having to transfer the blood into separate devices or containers thereby subjecting the blood to additional sources of contamination by exposure to the atmosphere.
  • a method for stabilizing a blood sample after collection in a hollow container which container comprises two closed ends connected by elongated sides, said sides having formed therein a reduced portion which extends inwardly into the interior of the hollow container, said container including a movable elastomeric closure means disposed in the interior of the hollow container between one of said closed ends in close proximity to the last-mentioned closed end and the reduced portion, such closure means having a deformable end extending toward the reduced portion, the other end of the closure means under normal conditions being in resilient engagement with the inner walls of said sides, which comprises (1) centrifuging said container at a speed that effects separation of the blood sample contained therein into two discrete phases, one phase consisting predominantly of the liquid constituent of the blood sample and the other consisting predominantly of the particulate phase; (2) increasing the centrifugal speed, to a speed which causes movement of the resilient member toward the reduced portion; and (3) centrifuging at such rate until the deformable end is securely received in the reduced portion.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Centrifugal Separators (AREA)
US00321430A 1973-01-05 1973-01-05 Blood collection container Expired - Lifetime US3786985A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32143073A 1973-01-05 1973-01-05
US39257973A 1973-08-29 1973-08-29

Publications (1)

Publication Number Publication Date
US3786985A true US3786985A (en) 1974-01-22

Family

ID=26982966

Family Applications (1)

Application Number Title Priority Date Filing Date
US00321430A Expired - Lifetime US3786985A (en) 1973-01-05 1973-01-05 Blood collection container

Country Status (8)

Country Link
US (1) US3786985A (de)
JP (1) JPS49103696A (de)
DD (1) DD110358A5 (de)
DE (1) DE2358493A1 (de)
FR (1) FR2213207A1 (de)
IT (1) IT1001920B (de)
NL (1) NL7316347A (de)
SE (1) SE7400120L (de)

Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3862042A (en) * 1974-02-27 1975-01-21 Becton Dickinson Co Serum/plasma separator - piston with red-cell trapping surfaces
US3879295A (en) * 1973-08-17 1975-04-22 Eastman Kodak Co Vacutainer with positive separation barrier
US3882021A (en) * 1974-02-27 1975-05-06 Becton Dickinson Co Sealed assembly for separation of blood with anti-red cell barrier
US3887464A (en) * 1974-02-27 1975-06-03 Becton Dickinson Co Serum/plasma separator with centrifugal valve seal
US3890237A (en) * 1974-02-27 1975-06-17 Becton Dickinson Co Plasma separator {13 {0 cord stop type
US3897343A (en) * 1974-02-27 1975-07-29 Becton Dickinson Co Plasma separator-hydrostatic pressure type
US3901219A (en) * 1974-07-25 1975-08-26 Becton Dickinson Co Blood collecting container and method
US3919085A (en) * 1974-02-27 1975-11-11 Becton Dickinson Co Plasma separator assembly
US3931010A (en) * 1974-02-27 1976-01-06 Becton, Dickinson And Company Serum/plasma separators with centrifugal valves
US3951801A (en) * 1974-02-27 1976-04-20 Becton, Dickinson And Company Serum/plasma separator-strut stop type
US4001122A (en) * 1973-08-22 1977-01-04 Telan Corporation Method and device for separating blood components
US4068798A (en) * 1976-09-29 1978-01-17 E. I. Du Pont De Nemours And Company Method and apparatus for stopper removal
USRE30276E (en) * 1976-09-29 1980-05-20 E. I. Du Pont De Nemours And Company Apparatus for stopper removal
EP0017127A2 (de) * 1979-03-23 1980-10-15 Terumo Corporation Verfahren zum Fraktionieren von Blut und Trennvorrichtung hierfür
US5560830A (en) * 1994-12-13 1996-10-01 Coleman; Charles M. Separator float and tubular body for blood collection and separation and method of use thereof
US5736033A (en) * 1995-12-13 1998-04-07 Coleman; Charles M. Separator float for blood collection tubes with water swellable material
US20020156439A1 (en) * 1997-09-12 2002-10-24 Michael J. Iskra Collection container assembly
US7074577B2 (en) 2002-10-03 2006-07-11 Battelle Memorial Institute Buffy coat tube and float system and method
US20100140182A1 (en) * 2008-12-04 2010-06-10 Chapman John R Apparatus and method for separating and isolating components of a biological fluid
US20100160135A1 (en) * 2008-07-21 2010-06-24 Becton, Dickinson And Company Density Phase Separation Device
US20100288694A1 (en) * 2009-05-15 2010-11-18 Becton, Dickinson And Company Density Phase Separation Device
US8394342B2 (en) 2008-07-21 2013-03-12 Becton, Dickinson And Company Density phase separation device
US20150231631A1 (en) * 2012-11-30 2015-08-20 Rarecyte, Inc. Apparatus, system, and method for collecting a target material
US9333445B2 (en) 2008-07-21 2016-05-10 Becton, Dickinson And Company Density phase separation device
US9682373B2 (en) 1999-12-03 2017-06-20 Becton, Dickinson And Company Device for separating components of a fluid sample
US9694359B2 (en) 2014-11-13 2017-07-04 Becton, Dickinson And Company Mechanical separator for a biological fluid
US11697114B2 (en) * 2015-12-11 2023-07-11 Babson Diagnostics, Inc. Centrifugation method separating serum or plasma from whole blood using a specimen container having a cap to retain blood cells
US12025629B2 (en) 2022-04-06 2024-07-02 Babson Diagnostics, Inc. Automated centrifuge loader
US12050052B1 (en) 2021-08-06 2024-07-30 Babson Diagnostics, Inc. Refrigerated carrier device for biological samples
US12174207B2 (en) 2016-11-14 2024-12-24 Babson Diagnostics, Inc. Blood sample preparation device and methods

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932222A (en) * 1974-12-20 1976-01-13 J. K. & Susie L. Wadley Research Institute And Blood Bank For isolating pathogenic microorganisms
US4022576A (en) * 1975-06-09 1977-05-10 I. C. L. Scientific Method and apparatus for preparation of liquids containing suspended material for examination
US4361155A (en) * 1980-10-29 1982-11-30 Anastasio Frank W Blood sampling unit
US4830209A (en) * 1988-05-09 1989-05-16 Multi-Technology Inc. Fail safe releasible locks for cappped disposable centrifuge containers
US5533518A (en) * 1994-04-22 1996-07-09 Becton, Dickinson And Company Blood collection assembly including mechanical phase separating insert
WO1996024058A1 (fr) * 1995-01-30 1996-08-08 Niigata Engineering Co., Ltd. Element de separation de composants et separateur de composants equipe dudit element
US6179787B1 (en) * 1997-09-12 2001-01-30 Becton Dickinson And Company Collection container assembly

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3508653A (en) * 1967-11-17 1970-04-28 Charles M Coleman Method and apparatus for fluid handling and separation
US3579303A (en) * 1968-03-06 1971-05-18 Donald E Pickering System for handling specimens and other substances in medicine and physical sciences
US3647070A (en) * 1970-06-11 1972-03-07 Technicon Corp Method and apparatus for the provision of fluid interface barriers

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3508653A (en) * 1967-11-17 1970-04-28 Charles M Coleman Method and apparatus for fluid handling and separation
US3579303A (en) * 1968-03-06 1971-05-18 Donald E Pickering System for handling specimens and other substances in medicine and physical sciences
US3647070A (en) * 1970-06-11 1972-03-07 Technicon Corp Method and apparatus for the provision of fluid interface barriers

Cited By (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3879295A (en) * 1973-08-17 1975-04-22 Eastman Kodak Co Vacutainer with positive separation barrier
US4001122A (en) * 1973-08-22 1977-01-04 Telan Corporation Method and device for separating blood components
US3931010A (en) * 1974-02-27 1976-01-06 Becton, Dickinson And Company Serum/plasma separators with centrifugal valves
US3887464A (en) * 1974-02-27 1975-06-03 Becton Dickinson Co Serum/plasma separator with centrifugal valve seal
US3890237A (en) * 1974-02-27 1975-06-17 Becton Dickinson Co Plasma separator {13 {0 cord stop type
US3897343A (en) * 1974-02-27 1975-07-29 Becton Dickinson Co Plasma separator-hydrostatic pressure type
US3919085A (en) * 1974-02-27 1975-11-11 Becton Dickinson Co Plasma separator assembly
US3862042A (en) * 1974-02-27 1975-01-21 Becton Dickinson Co Serum/plasma separator - piston with red-cell trapping surfaces
US3951801A (en) * 1974-02-27 1976-04-20 Becton, Dickinson And Company Serum/plasma separator-strut stop type
US3882021A (en) * 1974-02-27 1975-05-06 Becton Dickinson Co Sealed assembly for separation of blood with anti-red cell barrier
US3901219A (en) * 1974-07-25 1975-08-26 Becton Dickinson Co Blood collecting container and method
US4068798A (en) * 1976-09-29 1978-01-17 E. I. Du Pont De Nemours And Company Method and apparatus for stopper removal
USRE30276E (en) * 1976-09-29 1980-05-20 E. I. Du Pont De Nemours And Company Apparatus for stopper removal
EP0017127A2 (de) * 1979-03-23 1980-10-15 Terumo Corporation Verfahren zum Fraktionieren von Blut und Trennvorrichtung hierfür
EP0017127A3 (en) * 1979-03-23 1980-12-10 Terumo Corporation A method for separating blood and a barrier device therefor
US5560830A (en) * 1994-12-13 1996-10-01 Coleman; Charles M. Separator float and tubular body for blood collection and separation and method of use thereof
US5736033A (en) * 1995-12-13 1998-04-07 Coleman; Charles M. Separator float for blood collection tubes with water swellable material
US20020156439A1 (en) * 1997-09-12 2002-10-24 Michael J. Iskra Collection container assembly
US9682373B2 (en) 1999-12-03 2017-06-20 Becton, Dickinson And Company Device for separating components of a fluid sample
US7074577B2 (en) 2002-10-03 2006-07-11 Battelle Memorial Institute Buffy coat tube and float system and method
US20110171680A1 (en) * 2002-10-03 2011-07-14 Battelle Memorial Institute Buffy coat tube and float system and method
US20080128340A1 (en) * 2002-10-03 2008-06-05 Thomas Haubert Buffy coat tube and float system and method
US20060154308A1 (en) * 2002-10-03 2006-07-13 Battelle Memorial Institute Buffy coat tube and float system and method
US7329534B2 (en) 2002-10-03 2008-02-12 Battelle Memorial Institute Buffy coat tube and float system and method
US8012742B2 (en) 2002-10-03 2011-09-06 Battelle Memorial Institute Buffy coat tube and float system and method
US7915029B2 (en) 2002-10-03 2011-03-29 Battelle Memorial Institute Buffy coat tube and float system and method
US9714890B2 (en) 2008-07-21 2017-07-25 Becton, Dickinson And Company Density phase separation device
US9933344B2 (en) 2008-07-21 2018-04-03 Becton, Dickinson And Company Density phase separation device
US20100160135A1 (en) * 2008-07-21 2010-06-24 Becton, Dickinson And Company Density Phase Separation Device
US9700886B2 (en) 2008-07-21 2017-07-11 Becton, Dickinson And Company Density phase separation device
US10350591B2 (en) 2008-07-21 2019-07-16 Becton, Dickinson And Company Density phase separation device
US8394342B2 (en) 2008-07-21 2013-03-12 Becton, Dickinson And Company Density phase separation device
US9452427B2 (en) 2008-07-21 2016-09-27 Becton, Dickinson And Company Density phase separation device
US9333445B2 (en) 2008-07-21 2016-05-10 Becton, Dickinson And Company Density phase separation device
US9339741B2 (en) 2008-07-21 2016-05-17 Becton, Dickinson And Company Density phase separation device
US8747781B2 (en) 2008-07-21 2014-06-10 Becton, Dickinson And Company Density phase separation device
US8511479B2 (en) * 2008-12-04 2013-08-20 Thermogenesis Corp. Apparatus and method for separating and isolating components of a biological fluid
US8506823B2 (en) * 2008-12-04 2013-08-13 Thermogenesis Corp. Apparatus and method for separating and isolating components of a biological fluid
US20100140182A1 (en) * 2008-12-04 2010-06-10 Chapman John R Apparatus and method for separating and isolating components of a biological fluid
US8177072B2 (en) 2008-12-04 2012-05-15 Thermogenesis Corp. Apparatus and method for separating and isolating components of a biological fluid
US20120122649A1 (en) * 2008-12-04 2012-05-17 Chapman John R Apparatus and method for separating and isolating components of a biological fluid
US8511480B2 (en) * 2008-12-04 2013-08-20 Thermogenesis Corp. Apparatus and method for separating and isolating components of a biological fluid
US20120193274A1 (en) * 2008-12-04 2012-08-02 Chapman John R Apparatus and method for separating and isolating components of a biological fluid
US9375661B2 (en) 2008-12-04 2016-06-28 Cesca Therapeutics, Inc. Apparatus and method for separating and isolating components of a biological fluid
US10807088B2 (en) 2009-05-15 2020-10-20 Becton, Dickinson And Company Density phase separation device
US9079123B2 (en) 2009-05-15 2015-07-14 Becton, Dickinson And Company Density phase separation device
US9364828B2 (en) 2009-05-15 2016-06-14 Becton, Dickinson And Company Density phase separation device
US12090476B2 (en) 2009-05-15 2024-09-17 Becton, Dickinson And Company Density phase separation device
US8794452B2 (en) 2009-05-15 2014-08-05 Becton, Dickinson And Company Density phase separation device
US11786895B2 (en) 2009-05-15 2023-10-17 Becton, Dickinson And Company Density phase separation device
US9731290B2 (en) 2009-05-15 2017-08-15 Becton, Dickinson And Company Density phase separation device
US9802189B2 (en) 2009-05-15 2017-10-31 Becton, Dickinson And Company Density phase separation device
US9919308B2 (en) 2009-05-15 2018-03-20 Becton, Dickinson And Company Density phase separation device
US9919307B2 (en) 2009-05-15 2018-03-20 Becton, Dickinson And Company Density phase separation device
US9919309B2 (en) 2009-05-15 2018-03-20 Becton, Dickinson And Company Density phase separation device
US20100288694A1 (en) * 2009-05-15 2010-11-18 Becton, Dickinson And Company Density Phase Separation Device
US10343157B2 (en) 2009-05-15 2019-07-09 Becton, Dickinson And Company Density phase separation device
US11351535B2 (en) 2009-05-15 2022-06-07 Becton, Dickinson And Company Density phase separation device
US10376879B2 (en) 2009-05-15 2019-08-13 Becton, Dickinson And Company Density phase separation device
US10413898B2 (en) 2009-05-15 2019-09-17 Becton, Dickinson And Company Density phase separation device
US10456782B2 (en) 2009-05-15 2019-10-29 Becton, Dickinson And Company Density phase separation device
US8998000B2 (en) 2009-05-15 2015-04-07 Becton, Dickinson And Company Density phase separation device
US9533303B2 (en) * 2012-11-30 2017-01-03 Rarecyte, Inc. Apparatus, system, and method for collecting a target material
US20150231631A1 (en) * 2012-11-30 2015-08-20 Rarecyte, Inc. Apparatus, system, and method for collecting a target material
US9694359B2 (en) 2014-11-13 2017-07-04 Becton, Dickinson And Company Mechanical separator for a biological fluid
US11697114B2 (en) * 2015-12-11 2023-07-11 Babson Diagnostics, Inc. Centrifugation method separating serum or plasma from whole blood using a specimen container having a cap to retain blood cells
US12059676B1 (en) 2015-12-11 2024-08-13 Babson Diagnostics, Inc. Device and method for testing serum and plasma separated from blood cells in whole blood samples
US12174207B2 (en) 2016-11-14 2024-12-24 Babson Diagnostics, Inc. Blood sample preparation device and methods
US12050052B1 (en) 2021-08-06 2024-07-30 Babson Diagnostics, Inc. Refrigerated carrier device for biological samples
US12025629B2 (en) 2022-04-06 2024-07-02 Babson Diagnostics, Inc. Automated centrifuge loader

Also Published As

Publication number Publication date
NL7316347A (de) 1974-07-09
JPS49103696A (de) 1974-10-01
IT1001920B (it) 1976-04-30
DD110358A5 (de) 1974-12-12
SE7400120L (de) 1974-07-08
DE2358493A1 (de) 1974-07-25
FR2213207A1 (de) 1974-08-02

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