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US3727614A - Multiple dosage inoculator - Google Patents

Multiple dosage inoculator Download PDF

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Publication number
US3727614A
US3727614A US00142957A US3727614DA US3727614A US 3727614 A US3727614 A US 3727614A US 00142957 A US00142957 A US 00142957A US 3727614D A US3727614D A US 3727614DA US 3727614 A US3727614 A US 3727614A
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Prior art keywords
piston
needle
bellows
muzzle
inoculator
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US00142957A
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M Kniazuk
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Merck and Co Inc
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Merck and Co Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/204—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically connected to external reservoirs for multiple refilling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31561—Mechanically operated dose setting member using freely adjustable volume steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31563—Mechanically operated dose setting member interacting with a displaceable stop member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/42—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
    • A61M5/425—Protruding skin to facilitate piercing, e.g. vacuum cylinders, vein immobilising means

Definitions

  • ABSTRACT An inoculator having a muzzle surrounding the needle and a vacuum source to urge a piston forward and to draw the skin of the patient into the muzzle thereby impaling the 'skin of the patient upon the needle, automatically effecting the inoculation.
  • ATTORNEY MULTIPLE DOSAGE INOCULATOR This invention relates to a new multiple dosage inoculator which can be used to administer vaccines'and other injectable pharmaceutical or nutritional preparations to patients (human and animal).
  • this invention relates to a device which permits the rapid and efficient administration of injectable preparationsby using a vacuum to draw the skin of the patient onto the needle;
  • This invention also relates to a device which eliminates the hazard of the accidental inoculation of the one administering the injectable preparation.
  • the handle portion 2 includes a handle 5, trigger 6, and
  • compositions must be parenterally administered.
  • Single dosage injection devices are not satisfactory for this purpose due to the time and expense involved and also because of the variations in the doseswhich may be required by different patients as 'may be determined upon examination.
  • Another object is to provide a multiple dosage inoculator which does not require refilling between injections.
  • FIG. 2 is a longitudinal sectional view of the. barrel trigger guard 7.
  • the handle 5 is connected to a vacuum source (not shown) by fitting 8 and flexible tubing 9.
  • the handle has a cavity which contains an air filter 10 which may be removed so that it can be cleaned or changed by rotating the thumb screw 11.
  • the filter 10 communicates with hollow channels 12 and 13.
  • Channel'l2 can communicate with the atmosphere by means of channel 14.
  • the access of channel l4to the atmosphere is controlled by trigger 6, which reciprocates between the portion shown in FIG. 1 and one in which the channel 14 in the handle is in communication with the channel 15 and aperture 16 in the trigger 6.
  • a spring 17 mounted on.
  • elbow 18 and recess 19 exerts pressure on the trigger 6 to keep it in the position shown in FIG. 1.
  • Channel 12 also communicates with the muzzle 20 of the delivery portion 3 of the inocula-
  • the delivery portion 3 of the inoculator includesan I adjustable thumb screw- 24, which controls thestroke portion of this inoculator embodying the'features of the I present invention;
  • FIG. 3 is a longitudinal sectional view of an inocula tor embodying the features of the present invention in which the operative parts. of the inoculator are shown in a first operating position;
  • FIG. 4 is a longitudinal sectional view of an inocula- -tor embodying the features of the present invention in which the operative parts of the inoculator are shown in a second operating position;
  • FIG. 5 is a longitudinal sectional view of a modification of an inoculator embodying the features of the present invention.
  • FIG. 6 is a longitudinal sectional view of an alternative trigger means in a first operating position for an inoculator embodying the features of the present invention
  • the jacket also has a vent 29 and a front collar30 which seals the bellows 22 and supports the syringe housing tube 31.
  • a set screw 32 locks the syringe housing tube 31 tothe front collar 30 in a. fairly air-tight fit.
  • the syringe is a conventional syringeas, for example, a Becton & Dickinson Luer-Lok.
  • the syringe comprises a barrel 33 that is fixed, and a piston 25, which is driven by the bellows 22 via a Teflon bumper 34 mounted on the stem 35 that is'part of the bellows end cover 36.
  • the bumper 34 contacts the syringe piston 25 atthe' thumb screw 24, the other end of which is set against a sleeve spacer 39.
  • O'ring 40 cushions the sleeve spacer 39 against the top .of the syringe barrel flange 41.
  • a Teflon'washer 42 cushions and air seals a second sleeve spacer 43 against the bottom of the syringe barrel flange 41.
  • a housing 44 surrounds the syringe barrel 33 and the other working parts of the syringeoThe housing 44 is partially capped at the one end to retain the sleeve spacers, and has a threaded cap 45 with a hole for the syringe barrel at the other.
  • the cap 45 serves to'clamp the sleeve spacers and syringe barrel in the housing.
  • the barrel 33 is terminated in a standard male syringefitting 46 to which is coupled a checkvalve fitting 47.
  • the check-valve fitting 47 is connected to the medicament reservoir 4 and the other end terminates in a standard male taper fitting 48 for a hypodermic needle.
  • the reservoir 4 is a bottle which contains either 100 or 250 doses of medicament.
  • the bottle is connected by a screw fitting 49 to the inlet seat portion 50 of the checkwalve fitting 47.
  • -Washers 51 and 52 are used to seal the bottle 4, the fitting 49 and the inlet seat 50.
  • An inlet check valve 53 and spring 54 are mounted in the inlet seat 50.
  • a washer 55 seals the inlet seat housing 50 to the check-valve body 47.
  • the outlet check valve 56 and spring 57 serve to prevent backflow.
  • the inlet valve 53 controls the entrance of the medicament to the metering chamber 58 and the outlet valve 56 controls the flow of medicament to the hypodermic needle 59.
  • the hypodermic needle 59 is mounted by its metal hub 60 to the needle fitting 48 on the check-valve body.
  • a muzzle is attached by threads to the check valve body. It surrounds the fitting 48, the needle 59, hub 60, and a collar 61 which slips onto the needle 59. The collar limits the depth and penetration of the needle.
  • the lip 62 of the muzzle contacts the skin during use.
  • FIG. 3 shows the device of FIGS. 1 and 2 in a first operating position.
  • the inoculator 1 is brought into contact with the skin 63 of a patient.
  • the inoculator is connected to a vacuum source (not shown) and suction is applied continuously to the muzzle portion 20 of the inoculator through channel 12 and tubing 21, drawing the skin 63 of the patient into the muzzle cavity 64, where it is impaled upon the needle 59.
  • the depth of the penetration of the needle 59 into the skin 63 of the patient is limited by the diameter of the muzzle cavity 64 and the length of the collar 61, both of which may be varied depending upon the desired depth of the penetration of the needle as, for example, in subcutaneous inoculations the depth will be less than for intramuscular inoculations. Also, in veterinary applications, the depth of penetration must be varied according to the site of the inoculation, the looseness of the skin or the thickness ofthe skin of the particular animal to which the pharmaceutical or nutritional preparation is being administered.
  • arlonger collar and smaller diameter muzzle will be u'sed than when a full grown chicken is being inoculated; and an even larger diameter muzzle and shorter collar will be used when a larger animal, as, for example, a cow or sheep, is being inoculated.
  • Another way of varying the penetration of the needle is to vary the initial tension of the return spring 38.
  • Air is withdrawn from the bellows 22 through tubing 23 and channel 13 while air enters the area between the jacket 28 and the bellows 22 through vent 29.
  • This difference in air pressure between the interior of the be]- lows and the exterior of the bellows causes the collapse of the bellows and the forward stroke of the stem and the syringe piston 25 against the pressure of the return spring (not shown in FIG. 3).
  • check valve 53 which leads from the'fluid reservoir 4 to the metering chamber (58), is closed, and the check valve 56, which leads from the metering chamber 58 to the needle 59 is open.
  • a metered dose of the pharmaceutiea] or nutritional preparation is administered to the patient through the needle 59.
  • the vacuum system is closed. The system is evacuated very quickly (less than one second), but not instantaneously. At the onset of evacuation, the skin is sucked into the muzzle and impaled upon the needle. As the evacuation continues, the bellows overcomes the initial spring tension and starts to collapse, thereby administering the injectable preparation to the patient.
  • the device When the preparation has been administered to the patient and it is desired to remove the inoculator from the patient and inoculate another patient, the device is in the position shown in FIG. 4.
  • the person using the inoculator depresses the trigger 6, thereby aligning channel 15 in the trigger with channel 14in the handle.
  • channel 12 and channel 14 may communicate with the atmosphere by means of channel 15 and aperture 16 in the trigger.
  • air flows through channel 12 to muzzle 20 and breaks the suction between the muzzle 20 and the skin 63 of the patient.
  • Air simultaneously flows through channel 13 into the bellows 22, thereby in conjunction with the return spring causing the bellows to expand until the stem 35 is brought into contact with locking nut 26.
  • check valve 53 opens and check valve 56 closes, thereby refilling the metering chamber 58.
  • the inoculator is then ready to be used again.
  • the device shown in FIG. 5 is an alternative embodiment of an inoculator embodying the features of the present invention in which the trigger is activated by means of the movement of a finger 71 which is pivotably mounted by means of a pin 72 on an arm 73.
  • the movement of this arm may be activated by several means (not shown), including mechanical means, such as a foot pedal or other switch device, or by electrical switching means, such as a solenoid.
  • the trigger When the trigger is activated by means ofa device as shown in FIG. 5, its primary utility is in veterinary applications wherein the inoculator may be mounted on a fixed support 74 and the animal is brought to the inoculator by the operator.
  • the inoculator is connected to a source for the pharmaceutical or nutritional preparation by tube 75.
  • tube 75 For example, in commercial hatchery operations, it may be convenient to use a fixedly mounted inoculator as shown in FIG. 5 in conjunction with other equipment as, for example, debeaking machines, which are normally used in the processing of animals.
  • FIG. 6 and FIG. 7 illustrates an alternative trigger assembly in which the trigger as it is depressed moves a cap 81 away from an aperture 82, thereby opening the path for the channel and enabling air to flow to the muzzle to break the-suction and enable the animal to be readily removed from the inoculator.
  • a cumulative counter to a vacuum operated switch which is connected to the tubing 9 which connects the inoculator to the vacuum source.
  • a dye in the injectable preparation may also be used to indicate whether or not the inoculation has actually occurred.
  • Other suitable means may also be used to perform this function.
  • a piston which is connected to the syringe piston and in an air-tight relationship with the jacket 28. By evacuating the area below the piston, this piston will move and cause the syringe piston 25 to be driven forward and release the injectable preparation. By releasing the vacuum, this piston will move rearward and cause the syringe piston 25 to recycle.
  • An inoculator for administering metered doses of injectable preparations to patients comprising:
  • a metering chamber in communication with said source of supply
  • cylindrical muzzle spaced from and surrounding said needle, said cylindrical muzzle extending at least as far as the tip of said needle and having an essentially flat edgeat the end thereof;
  • a vacuum source connected to said muzzle in order to impale the skin of the patient being inoculated on said'needle;
  • a piston mounted for reciprocal forward and rearward movement in said bellows, the rearward end of said piston being in communication with the rearward wall of said bellows, and the front end of said piston extending beyond the front edge of said bellows and being slidingly engaged with the interior wall of the metering chamber;
  • a device as in claim 1 further including means to break the vacuum, thereby facilitating the removal of the needle from the piston.
  • a device as in claim 1 further including means to vary the volume of the injectable preparation being administered to the patient.
  • a device as in claim 3 wherein the means to vary the volume of the injectable preparation comprises an adjustable screw which controls the rearward position of the piston, thereby regulating the maximum volume of the metering chamber.

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  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Finger-Pressure Massage (AREA)

Abstract

An inoculator having a muzzle surrounding the needle and a vacuum source to urge a piston forward and to draw the skin of the patient into the muzzle thereby impaling the skin of the patient upon the needle, automatically effecting the inoculation.

Description

[22] Filed: [21] AppLNo; 142,957
1 United States Patent 1191 Kniazuk MULTIPLE DOSAGE INOCULATOR [75] Inventor: Michael Kniazuk, Mountainside,
[73] Assignee: Merck & Co., Inc., Rahway, NJ.
May 13, 1971 [52] US. Cl. ..128/218 A, 128/218 G, 128/302 51 1111. c1..,., ..A6l1'n 5/18, A61m 1/00 [58] Field of Search ..128/2l8 A, 218 0, 08/27 ,215, 2'18 R,218 F,2F, 173 H, 223, 315, 297, 302, 278
[ 56] References Cited UNITED STATES PATENTS KWM/M Jae/ea:
1451 Apr. 17,1973
3,474,787 10/1969 Grant 128/218 R 1,880,354 10/1932 Mueller ..128/216 ux FOREIGN PATENTS OR APPLICATIONS 315,583 2/1934 Italy 128/302 120,379 5/1927 Switzerland ....128/302 155,380 8/1938 Austria; 128/297 1,048,558 9/1963 Great Britain. 128/302 Great Britain .1 ..128/218 F Primary Examiner-Richard A. Gaudet Assistant Examiner-J. C. McGowan Attorney-Martin L. Katz, Harry E. Westlake, Jr. and 1. Louis Wolk [57] ABSTRACT An inoculator having a muzzle surrounding the needle and a vacuum source to urge a piston forward and to draw the skin of the patient into the muzzle thereby impaling the 'skin of the patient upon the needle, automatically effecting the inoculation.
PATEFHEDAPR 1 Y W 31727, 614
ATTORNEY MULTIPLE DOSAGE INOCULATOR This invention relates to a new multiple dosage inoculator which can be used to administer vaccines'and other injectable pharmaceutical or nutritional preparations to patients (human and animal).
More particularly, this invention relates to a device which permits the rapid and efficient administration of injectable preparationsby using a vacuum to draw the skin of the patient onto the needle;
This invention also relates to a device which eliminates the hazard of the accidental inoculation of the one administering the injectable preparation.
In the medical and veterinary profession, it is frequently necessary to administer accurate doses of therapeutic or nutritional compositions to large groups V The handle portion 2 includes a handle 5, trigger 6, and
of patients. Many of these compositions must be parenterally administered. Single dosage injection devices are not satisfactory for this purpose due to the time and expense involved and also because of the variations in the doseswhich may be required by different patients as 'may be determined upon examination.
Accordingly, it is thegeneral object of the present invention to provide a novel and improved multiple dosage inoculator;
- Another object is to provide a multiple dosage inoculator which does not require refilling between injections. Q
A further objectis to provide a novel multiple dosage from the following detailed description and accom' partying drawings in which:
-FlG.'l'is a longitudinal sectional view of an inoculator embodying the features of the present invention; FIG. 2 is a longitudinal sectional view of the. barrel trigger guard 7. The handle 5 is connected to a vacuum source (not shown) by fitting 8 and flexible tubing 9. The handle has a cavity which contains an air filter 10 which may be removed so that it can be cleaned or changed by rotating the thumb screw 11. The filter 10 communicates with hollow channels 12 and 13. Channel'l2 can communicate with the atmosphere by means of channel 14. The access of channel l4to the atmosphere is controlled by trigger 6, which reciprocates between the portion shown in FIG. 1 and one in which the channel 14 in the handle is in communication with the channel 15 and aperture 16 in the trigger 6. A spring 17 mounted on. elbow 18 and recess 19 exerts pressure on the trigger 6 to keep it in the position shown in FIG. 1. Channel 12 also communicates with the muzzle 20 of the delivery portion 3 of the inocula- The delivery portion 3 of the inoculator includesan I adjustable thumb screw- 24, which controls thestroke portion of this inoculator embodying the'features of the I present invention;
FIG. 3 is a longitudinal sectional view of an inocula tor embodying the features of the present invention in which the operative parts. of the inoculator are shown in a first operating position;
FIG. 4 is a longitudinal sectional view of an inocula- -tor embodying the features of the present invention in which the operative parts of the inoculator are shown in a second operating position;
FIG. 5 is a longitudinal sectional view of a modification of an inoculator embodying the features of the present invention;
FIG. 6 is a longitudinal sectional view of an alternative trigger means in a first operating position for an inoculator embodying the features of the present invention;
of the syringe piston 25, and a locking nut 26 which are both mounted on the rear facing; 27 of the jacket 28. The jacket also has a vent 29 and a front collar30 which seals the bellows 22 and supports the syringe housing tube 31. A set screw 32 locks the syringe housing tube 31 tothe front collar 30 in a. fairly air-tight fit. The syringe is a conventional syringeas, for example, a Becton & Dickinson Luer-Lok. The syringe comprises a barrel 33 that is fixed, and a piston 25, which is driven by the bellows 22 via a Teflon bumper 34 mounted on the stem 35 that is'part of the bellows end cover 36.
The bumper 34 contacts the syringe piston 25 atthe' thumb screw 24, the other end of which is set against a sleeve spacer 39. .An O'ring 40 cushions the sleeve spacer 39 against the top .of the syringe barrel flange 41. A Teflon'washer 42 cushions and air seals a second sleeve spacer 43 against the bottom of the syringe barrel flange 41. A housing 44 surrounds the syringe barrel 33 and the other working parts of the syringeoThe housing 44 is partially capped at the one end to retain the sleeve spacers, and has a threaded cap 45 with a hole for the syringe barrel at the other. The cap 45 serves to'clamp the sleeve spacers and syringe barrel in the housing. The barrel 33 is terminated in a standard male syringefitting 46 to which is coupled a checkvalve fitting 47. The check-valve fitting 47 is connected to the medicament reservoir 4 and the other end terminates in a standard male taper fitting 48 for a hypodermic needle. In theernbodiments shown in FIGS. 1 and 2, the reservoir 4 is a bottle which contains either 100 or 250 doses of medicament. The bottle is connected by a screw fitting 49 to the inlet seat portion 50 of the checkwalve fitting 47. -Washers 51 and 52 are used to seal the bottle 4, the fitting 49 and the inlet seat 50. An inlet check valve 53 and spring 54 are mounted in the inlet seat 50. A washer 55 seals the inlet seat housing 50 to the check-valve body 47. The outlet check valve 56 and spring 57 serve to prevent backflow. The inlet valve 53 controls the entrance of the medicament to the metering chamber 58 and the outlet valve 56 controls the flow of medicament to the hypodermic needle 59. The hypodermic needle 59 is mounted by its metal hub 60 to the needle fitting 48 on the check-valve body. A muzzle is attached by threads to the check valve body. It surrounds the fitting 48, the needle 59, hub 60, and a collar 61 which slips onto the needle 59. The collar limits the depth and penetration of the needle. The lip 62 of the muzzle contacts the skin during use.
FIG. 3 shows the device of FIGS. 1 and 2 in a first operating position. In this view the inoculator 1 is brought into contact with the skin 63 of a patient. The inoculator is connected to a vacuum source (not shown) and suction is applied continuously to the muzzle portion 20 of the inoculator through channel 12 and tubing 21, drawing the skin 63 of the patient into the muzzle cavity 64, where it is impaled upon the needle 59. The depth of the penetration of the needle 59 into the skin 63 of the patient is limited by the diameter of the muzzle cavity 64 and the length of the collar 61, both of which may be varied depending upon the desired depth of the penetration of the needle as, for example, in subcutaneous inoculations the depth will be less than for intramuscular inoculations. Also, in veterinary applications, the depth of penetration must be varied according to the site of the inoculation, the looseness of the skin or the thickness ofthe skin of the particular animal to which the pharmaceutical or nutritional preparation is being administered. For example, when a, young, i.e., 1-5 day old chick is being inoculated, arlonger collar and smaller diameter muzzle will be u'sed than when a full grown chicken is being inoculated; and an even larger diameter muzzle and shorter collar will be used when a larger animal, as, for example, a cow or sheep, is being inoculated.
Another way of varying the penetration of the needle is to vary the initial tension of the return spring 38. If
the tension is increased, a greater vacuum is needed to depress the syringe barrel and, consequently, there is a greater vacuum in the muzzle cavity 64. One may vary the angle at which the point of the needle 59 is sharpened to control the depth of penetration of the needle.
Air is withdrawn from the bellows 22 through tubing 23 and channel 13 while air enters the area between the jacket 28 and the bellows 22 through vent 29. This difference in air pressure between the interior of the be]- lows and the exterior of the bellows causes the collapse of the bellows and the forward stroke of the stem and the syringe piston 25 against the pressure of the return spring (not shown in FIG. 3). At this stage check valve 53, which leads from the'fluid reservoir 4 to the metering chamber (58), is closed, and the check valve 56, which leads from the metering chamber 58 to the needle 59 is open. Accordingly, as the syringe piston 25 is moving forward, a metered dose of the pharmaceutiea] or nutritional preparation is administered to the patient through the needle 59. One skilled in the art will readily see that when the muzzle 20 is brought into contact with the skin 63 of the patient, the vacuum system is closed. The system is evacuated very quickly (less than one second), but not instantaneously. At the onset of evacuation, the skin is sucked into the muzzle and impaled upon the needle. As the evacuation continues, the bellows overcomes the initial spring tension and starts to collapse, thereby administering the injectable preparation to the patient.
When the preparation has been administered to the patient and it is desired to remove the inoculator from the patient and inoculate another patient, the device is in the position shown in FIG. 4. In this view, the person using the inoculator depresses the trigger 6, thereby aligning channel 15 in the trigger with channel 14in the handle. At this point, channel 12 and channel 14 may communicate with the atmosphere by means of channel 15 and aperture 16 in the trigger. When this takes place, air flows through channel 12 to muzzle 20 and breaks the suction between the muzzle 20 and the skin 63 of the patient. Air simultaneously flows through channel 13 into the bellows 22, thereby in conjunction with the return spring causing the bellows to expand until the stem 35 is brought into contact with locking nut 26. This causes the syringe piston 25 to move rearwardly. At this time, check valve 53 opens and check valve 56 closes, thereby refilling the metering chamber 58. The inoculator is then ready to be used again.
The device shown in FIG. 5 is an alternative embodiment of an inoculator embodying the features of the present invention in which the trigger is activated by means of the movement of a finger 71 which is pivotably mounted by means of a pin 72 on an arm 73. The movement of this arm may be activated by several means (not shown), including mechanical means, such as a foot pedal or other switch device, or by electrical switching means, such as a solenoid. When the trigger is activated by means ofa device as shown in FIG. 5, its primary utility is in veterinary applications wherein the inoculator may be mounted on a fixed support 74 and the animal is brought to the inoculator by the operator. The inoculator is connected to a source for the pharmaceutical or nutritional preparation by tube 75. For example, in commercial hatchery operations, it may be convenient to use a fixedly mounted inoculator as shown in FIG. 5 in conjunction with other equipment as, for example, debeaking machines, which are normally used in the processing of animals.
The device shown in FIG. 6 and FIG. 7 illustrates an alternative trigger assembly in which the trigger as it is depressed moves a cap 81 away from an aperture 82, thereby opening the path for the channel and enabling air to flow to the muzzle to break the-suction and enable the animal to be readily removed from the inoculator.
One skilled in the art will readily realize that many other means may be used to break the suction between the patient and the muzzle and to recycle the syringe. In many situations it is not necessary to use a trigger mechanism to break the suction, but the inoculator may be pulled from the patient, thereby breaking the suction, without injuring the patient in any way.
If it is desired to count the patients being inoculated, it is possible to attach a cumulative counter to a vacuum operated switch which is connected to the tubing 9 which connects the inoculator to the vacuum source. One may also use a dye in the injectable preparation to indicate whether or not the inoculation has actually occurred. Other suitable means may also be used to perform this function.
As a possible alternative to the use of bellows to cause the syringe piston 26 to reciprocate, one may also utilize a piston which is connected to the syringe piston and in an air-tight relationship with the jacket 28. By evacuating the area below the piston, this piston will move and cause the syringe piston 25 to be driven forward and release the injectable preparation. By releasing the vacuum, this piston will move rearward and cause the syringe piston 25 to recycle.
What is claimed is:
1. An inoculator for administering metered doses of injectable preparations to patients comprising:
a source of supply for the injectable preparation to be administered;
a metering chamber in communication with said source of supply;
a hollow needle in communication with said metering chamber;
a cylindrical muzzle spaced from and surrounding said needle, said cylindrical muzzle extending at least as far as the tip of said needle and having an essentially flat edgeat the end thereof;
a vacuum source connected to said muzzle in order to impale the skin of the patient being inoculated on said'needle;
a bellows;
a piston mounted for reciprocal forward and rearward movement in said bellows, the rearward end of said piston being in communication with the rearward wall of said bellows, and the front end of said piston extending beyond the front edge of said bellows and being slidingly engaged with the interior wall of the metering chamber; and
a hollow tube one end of which is connected to the vacuum source, and the other end being connected to the interior of said bellows in order to cyclicly collapse and expand said bellows, thereby causing said piston to move forward and rearward in said metering chamber, whereby the piston only moves to inject the metered dose of injectable preparation when the muzzle is sealed against the skin of the patient.
2. A device as in claim 1 further including means to break the vacuum, thereby facilitating the removal of the needle from the piston.
3. A device as in claim 1 further including means to vary the volume of the injectable preparation being administered to the patient.
4. A device as in claim 3 wherein the means to vary the volume of the injectable preparation comprises an adjustable screw which controls the rearward position of the piston, thereby regulating the maximum volume of the metering chamber.

Claims (4)

1. An inoculator for administering metered doses of injectable preparations to patients comprising: a source of supply for the injectable preparation to be administered; a metering chamber in communication with said source of supply; a hollow needle in communication with said metering chamber; a cylindrical muzzle spaced from and surrounding said needle, said cylindrical muzzle extending at least as far as the tip of said needle and having an essentially flat edge at the end thereof; a vacuum source connected to said muzzle in order to impale the skin of the patient being inoculated on said needle; a bellows; a piston mounted for reciprocal forward and rearward movement in said bellows, the rearward end of said piston being in communication with the rearward wall of said bellows, and the front end of said piston extending beyond the front edge of said bellows and being sliDingly engaged with the interior wall of the metering chamber; and a hollow tube one end of which is connected to the vacuum source, and the other end being connected to the interior of said bellows in order to cyclicly collapse and expand said bellows, thereby causing said piston to move forward and rearward in said metering chamber, whereby the piston only moves to inject the metered dose of injectable preparation when the muzzle is sealed against the skin of the patient.
2. A device as in claim 1 further including means to break the vacuum, thereby facilitating the removal of the needle from the piston.
3. A device as in claim 1 further including means to vary the volume of the injectable preparation being administered to the patient.
4. A device as in claim 3 wherein the means to vary the volume of the injectable preparation comprises an adjustable screw which controls the rearward position of the piston, thereby regulating the maximum volume of the metering chamber.
US00142957A 1971-05-13 1971-05-13 Multiple dosage inoculator Expired - Lifetime US3727614A (en)

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Cited By (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3949748A (en) * 1974-09-26 1976-04-13 Oscar Malmin Injection syringe having aspirating and metering capabilities
DE2551993A1 (en) * 1974-11-19 1976-07-15 Wolfgang Dr Med Wagner SUCTION INJECTION WITH DOSING DEVICES ACCORDING TO THE DISPOSABLE PRINCIPLE
US3982899A (en) * 1975-05-22 1976-09-28 Corning Glass Works Fluid handling apparatus
US4108177A (en) * 1976-04-23 1978-08-22 Michel Louis Paul Pistor Automatic injector device
US4114619A (en) * 1975-11-21 1978-09-19 Wolfgang Wagner Automatic injecting apparatus
US4177810A (en) * 1977-12-23 1979-12-11 Damon Corporation Pneumatic injection apparatus
US4210173A (en) * 1976-12-06 1980-07-01 American Hospital Supply Corporation Syringe pumping system with valves
DE2922037A1 (en) * 1979-05-30 1980-12-11 Birk Michael PNEUMATICALLY OPERATED INJECTION DEVICE
US4299219A (en) * 1979-12-17 1981-11-10 Norris Jr George P Intravenous needle insertion device
DE3233720A1 (en) * 1981-02-24 1983-07-28 Edgar C Cohen VACUUM PRESSURE INJECTOR
US4909783A (en) * 1986-07-16 1990-03-20 Morrison David P Intra-ocular pressure apparatus
US4943294A (en) * 1988-03-30 1990-07-24 Y-Tex Corporation Power-driven applicator for tagging livestock
US5024664A (en) * 1990-04-26 1991-06-18 Baxter International Inc. Vacuum infusion device
US5792108A (en) * 1995-10-23 1998-08-11 C. R. Bard, Inc. Self-priming pulsed lavage pump
WO1999019009A1 (en) * 1997-10-14 1999-04-22 Merit Medical Systems, Inc. One-hand pulse pump
WO1999058185A1 (en) * 1998-05-13 1999-11-18 Anderson Mark L Injector pump
WO1999059663A1 (en) * 1998-05-16 1999-11-25 Microheart, Inc. Drug delivery module
US6059754A (en) * 1995-02-15 2000-05-09 C. R. Bard, Inc. Pulsed lavage pump with integral power source and variable flow control
US20030048775A1 (en) * 2001-09-10 2003-03-13 Siemens Aktiengesellschaft Method for routing data packets
US20030083641A1 (en) * 2001-10-26 2003-05-01 Massachusetts Institute Of Technology Impedance sensor
US6565533B1 (en) 2000-01-21 2003-05-20 Novus International, Inc. Inoculation apparatus and method
US6592552B1 (en) * 1997-09-19 2003-07-15 Cecil C. Schmidt Direct pericardial access device and method
US20040002726A1 (en) * 2002-06-28 2004-01-01 George Nunez Balloon-type actuator for surgical applications
US20040092875A1 (en) * 2002-11-08 2004-05-13 Kochamba Gary Steven Cutaneous injection delivery under suction
US20040243227A1 (en) * 2002-06-13 2004-12-02 Guided Delivery Systems, Inc. Delivery devices and methods for heart valve repair
US20050055087A1 (en) * 2003-09-04 2005-03-10 Guided Delivery Systems, Inc. Devices and methods for cardiac annulus stabilization and treatment
US20050065550A1 (en) * 2003-02-06 2005-03-24 Guided Delivery Systems, Inc. Delivery devices and methods for heart valve repair
US20050107812A1 (en) * 2002-06-13 2005-05-19 Guided Delivery Systems, Inc. Delivery devices and methods for heart valve repair
US20050256536A1 (en) * 2004-05-13 2005-11-17 Grundeman Paul F Device for making a cut in a tissue
US20050267520A1 (en) * 2004-05-12 2005-12-01 Modesitt D B Access and closure device and method
US7056307B2 (en) * 2001-02-02 2006-06-06 Smith James E Weight dependent, automatic filling dosage system and method of using same
US20060122633A1 (en) * 2002-06-13 2006-06-08 John To Methods and devices for termination
US20060264926A1 (en) * 2002-11-08 2006-11-23 Kochamba Gary S Cutaneous stabilization by vacuum for delivery of micro-needle array
US20060271078A1 (en) * 2005-05-12 2006-11-30 Modesitt D B Access and closure device and method
US20080051832A1 (en) * 2003-12-19 2008-02-28 John To Devices and methods for anchoring tissue
US20080177380A1 (en) * 2007-01-19 2008-07-24 Starksen Niel F Methods and devices for heart tissue repair
US20080234728A1 (en) * 2002-06-13 2008-09-25 Guided Delivery Systems, Inc. Devices and methods for heart valve repair
US20080287875A1 (en) * 2007-05-16 2008-11-20 Ecole Polytechnique Federale De Lausanne (Epfl) Infusion pump with phase separator
US20090082730A1 (en) * 2007-09-24 2009-03-26 Li Nguyen Needle injection assembly
US20090105744A1 (en) * 2007-10-17 2009-04-23 Modesitt D Bruce Methods for forming tracts in tissue
US20090157219A1 (en) * 2007-05-03 2009-06-18 Parker Jr Lance T Intelligent Sleeve Container for Use in a Controlled Syringe System
US20090173391A1 (en) * 2008-01-08 2009-07-09 Pradip Choksi Adjustable pressure relief valve
US20090222083A1 (en) * 2008-02-06 2009-09-03 Guided Delivery Systems Inc. Multi-window guide tunnel
US20090234318A1 (en) * 2007-10-19 2009-09-17 Guided Delivery Systems, Inc. Systems and methods for cardiac remodeling
US20100016796A1 (en) * 2008-03-25 2010-01-21 Animal Innovations, Inc. Syringe Mechanism for Detecting Syringe Status
US20100016810A1 (en) * 2008-07-21 2010-01-21 Arstasis. Inc., Devices and methods for forming tracts in tissue
US20100016786A1 (en) * 2008-07-21 2010-01-21 Arstasis, Inc. Devices, methods, and kits for forming tracts in tissue
US20100082098A1 (en) * 2002-06-13 2010-04-01 Starksen Niel F Delivery devices and methods for heart valve repair
US20110125178A1 (en) * 2009-05-15 2011-05-26 Michael Drews Devices, methods and kits for forming tracts in tissue
US20110172589A1 (en) * 2010-01-11 2011-07-14 Kenneth Finkelstein Surgical instrument having an integrated local anesthetic delivery system
US20110208215A1 (en) * 2009-09-22 2011-08-25 Modesitt D Bruce Devices, methods, and kits for forming tracts in tissue
US20110230833A1 (en) * 2010-03-21 2011-09-22 Mania Landman Device and Method for Injecting Fluids or Gels
US8287555B2 (en) 2003-02-06 2012-10-16 Guided Delivery Systems, Inc. Devices and methods for heart valve repair
US8795298B2 (en) 2008-10-10 2014-08-05 Guided Delivery Systems Inc. Tether tensioning devices and related methods
US9636106B2 (en) 2008-10-10 2017-05-02 Ancora Heart, Inc. Termination devices and related methods
WO2017147722A1 (en) 2016-02-29 2017-09-08 Medicel Ag Injection and/or aspiration device, in particular for ejecting and/or aspirating of a gas and/or a liquid
US9861350B2 (en) 2010-09-03 2018-01-09 Ancora Heart, Inc. Devices and methods for anchoring tissue
US20180028744A1 (en) * 2015-02-27 2018-02-01 E-Wha Meditech Inc. Medical fluid injector and medical fluid supply device including same
US9949829B2 (en) 2002-06-13 2018-04-24 Ancora Heart, Inc. Delivery devices and methods for heart valve repair
USD824509S1 (en) * 2016-12-19 2018-07-31 University Of The Free State Inoculator
WO2019169408A1 (en) * 2018-03-02 2019-09-06 Somnus Medical, LLC Iv set or iv set system with unidirectional access port
US10441753B2 (en) 2012-05-25 2019-10-15 Arstasis, Inc. Vascular access configuration
US20190343502A1 (en) * 2016-12-30 2019-11-14 Advanced Medical Solutions Limited Adhesive applicator
US10667914B2 (en) 2016-11-18 2020-06-02 Ancora Heart, Inc. Myocardial implant load sharing device and methods to promote LV function
US10675447B2 (en) 2012-05-25 2020-06-09 Arstasis, Inc. Vascular access configuration
US10980973B2 (en) 2015-05-12 2021-04-20 Ancora Heart, Inc. Device and method for releasing catheters from cardiac structures
US11672524B2 (en) 2019-07-15 2023-06-13 Ancora Heart, Inc. Devices and methods for tether cutting
US12257151B2 (en) 2020-04-17 2025-03-25 Ancora Heart, Inc. Myocardial implant load sharing device and methods to promote LV function

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2551991A1 (en) * 1974-11-19 1976-07-29 Wolfgang Dr Med Wagner Medication metering distributor for hypodermic - has dosing unit on flexible wall transmitting power pulses
EP3443947B1 (en) * 2017-08-15 2021-09-29 Prodictis SA Device for preparing a dose of material

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH120379A (en) * 1926-04-19 1927-05-16 Linder Armand Cupping machine.
US1880354A (en) * 1931-07-30 1932-10-04 Herman C Mueller Fluid gun
US1934046A (en) * 1931-10-30 1933-11-07 Demarchi Mario Syringe for hypodermic medical injections
AT155380B (en) * 1937-10-23 1939-01-10 Richard Haas Method and device for removing foreign bodies from the human or animal body, in particular from the human skin.
GB729316A (en) * 1952-03-24 1955-05-04 Nat Res Dev Improvements in hypodermic syringes
US2743723A (en) * 1954-06-03 1956-05-01 George N Hein Hypodermic injection apparatus
US2945496A (en) * 1958-08-18 1960-07-19 Fosdal Alfred Dental instrument for immobilizing tissue
US3122138A (en) * 1960-06-27 1964-02-25 Geary William Richard Clifford Hypodermic injection apparatus
GB1048558A (en) * 1963-09-03 1966-11-16 Vacuum Extractor Ab Improvements in or relating to instruments for draining cysts
US3353537A (en) * 1965-08-11 1967-11-21 George W Knox Automatic multi-dosage inoculating instrument
US3474787A (en) * 1967-04-05 1969-10-28 Sidney Grant Hypodermic syringe
US3618846A (en) * 1969-02-17 1971-11-09 Patrick J Poli Manually operated suction device

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH120379A (en) * 1926-04-19 1927-05-16 Linder Armand Cupping machine.
US1880354A (en) * 1931-07-30 1932-10-04 Herman C Mueller Fluid gun
US1934046A (en) * 1931-10-30 1933-11-07 Demarchi Mario Syringe for hypodermic medical injections
AT155380B (en) * 1937-10-23 1939-01-10 Richard Haas Method and device for removing foreign bodies from the human or animal body, in particular from the human skin.
GB729316A (en) * 1952-03-24 1955-05-04 Nat Res Dev Improvements in hypodermic syringes
US2743723A (en) * 1954-06-03 1956-05-01 George N Hein Hypodermic injection apparatus
US2945496A (en) * 1958-08-18 1960-07-19 Fosdal Alfred Dental instrument for immobilizing tissue
US3122138A (en) * 1960-06-27 1964-02-25 Geary William Richard Clifford Hypodermic injection apparatus
GB1048558A (en) * 1963-09-03 1966-11-16 Vacuum Extractor Ab Improvements in or relating to instruments for draining cysts
US3353537A (en) * 1965-08-11 1967-11-21 George W Knox Automatic multi-dosage inoculating instrument
US3474787A (en) * 1967-04-05 1969-10-28 Sidney Grant Hypodermic syringe
US3618846A (en) * 1969-02-17 1971-11-09 Patrick J Poli Manually operated suction device

Cited By (141)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3949748A (en) * 1974-09-26 1976-04-13 Oscar Malmin Injection syringe having aspirating and metering capabilities
DE2551993A1 (en) * 1974-11-19 1976-07-15 Wolfgang Dr Med Wagner SUCTION INJECTION WITH DOSING DEVICES ACCORDING TO THE DISPOSABLE PRINCIPLE
US3982899A (en) * 1975-05-22 1976-09-28 Corning Glass Works Fluid handling apparatus
US4114619A (en) * 1975-11-21 1978-09-19 Wolfgang Wagner Automatic injecting apparatus
US4108177A (en) * 1976-04-23 1978-08-22 Michel Louis Paul Pistor Automatic injector device
US4210173A (en) * 1976-12-06 1980-07-01 American Hospital Supply Corporation Syringe pumping system with valves
US4177810A (en) * 1977-12-23 1979-12-11 Damon Corporation Pneumatic injection apparatus
DE2922037A1 (en) * 1979-05-30 1980-12-11 Birk Michael PNEUMATICALLY OPERATED INJECTION DEVICE
US4299219A (en) * 1979-12-17 1981-11-10 Norris Jr George P Intravenous needle insertion device
DE3233720A1 (en) * 1981-02-24 1983-07-28 Edgar C Cohen VACUUM PRESSURE INJECTOR
US4909783A (en) * 1986-07-16 1990-03-20 Morrison David P Intra-ocular pressure apparatus
US4943294A (en) * 1988-03-30 1990-07-24 Y-Tex Corporation Power-driven applicator for tagging livestock
US5024664A (en) * 1990-04-26 1991-06-18 Baxter International Inc. Vacuum infusion device
US6059754A (en) * 1995-02-15 2000-05-09 C. R. Bard, Inc. Pulsed lavage pump with integral power source and variable flow control
US5792108A (en) * 1995-10-23 1998-08-11 C. R. Bard, Inc. Self-priming pulsed lavage pump
US6592552B1 (en) * 1997-09-19 2003-07-15 Cecil C. Schmidt Direct pericardial access device and method
WO1999019009A1 (en) * 1997-10-14 1999-04-22 Merit Medical Systems, Inc. One-hand pulse pump
US5951517A (en) * 1997-10-14 1999-09-14 Merit Medical Systems, Inc. One-hand pulse pump
WO1999058185A1 (en) * 1998-05-13 1999-11-18 Anderson Mark L Injector pump
US6063054A (en) * 1998-05-13 2000-05-16 Mark L. Anderson Injector pump
WO1999059663A1 (en) * 1998-05-16 1999-11-25 Microheart, Inc. Drug delivery module
US6565533B1 (en) 2000-01-21 2003-05-20 Novus International, Inc. Inoculation apparatus and method
US20030229312A1 (en) * 2000-01-21 2003-12-11 Novus International, Inc. Inoculation apparatus and method
US7056307B2 (en) * 2001-02-02 2006-06-06 Smith James E Weight dependent, automatic filling dosage system and method of using same
US20030048775A1 (en) * 2001-09-10 2003-03-13 Siemens Aktiengesellschaft Method for routing data packets
US20030139727A1 (en) * 2001-10-26 2003-07-24 Massachusetts Institute Of Technology Transdermal transport device with suction
US7651475B2 (en) 2001-10-26 2010-01-26 Massachusetts Institute Of Technology Microneedle transport device
US7364568B2 (en) 2001-10-26 2008-04-29 Massachusetts Institute Of Technology Microneedle transdermal transport device
US20030083619A1 (en) * 2001-10-26 2003-05-01 Massachusetts Institute Of Technology Microneedle transdermal transport device
US7429258B2 (en) 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US20080281273A1 (en) * 2001-10-26 2008-11-13 Massachusetts Institute Of Technology Microneedle transdermal transport device
US20080319392A1 (en) * 2001-10-26 2008-12-25 Angel Aimee B Microneedle transport device
US7645263B2 (en) 2001-10-26 2010-01-12 Massachusetts Institute Of Technology Impedance sensor
WO2003037407A1 (en) * 2001-10-26 2003-05-08 Massachusetts Institute Of Technology Transdermal transport device with suction
US8246582B2 (en) 2001-10-26 2012-08-21 Massachusetts Institute Of Technology Microneedle transdermal transport device
US20030083641A1 (en) * 2001-10-26 2003-05-01 Massachusetts Institute Of Technology Impedance sensor
AU2002348009B9 (en) * 2001-10-26 2006-08-10 Massachusetts Institute Of Technology Transdermal transport device with suction
AU2002348009B2 (en) * 2001-10-26 2006-06-29 Massachusetts Institute Of Technology Transdermal transport device with suction
US7066922B2 (en) 2001-10-26 2006-06-27 Massachusetts Institute Of Technology Transdermal transport device with suction
US20030083618A1 (en) * 2001-10-26 2003-05-01 Massachusetts Institute Of Technology Transdermal transport device with an electrolytic actuator
US8066766B2 (en) 2002-06-13 2011-11-29 Guided Delivery Systems Inc. Methods and devices for termination
US9949829B2 (en) 2002-06-13 2018-04-24 Ancora Heart, Inc. Delivery devices and methods for heart valve repair
US9072513B2 (en) 2002-06-13 2015-07-07 Guided Delivery Systems Inc. Methods and devices for termination
US9226825B2 (en) 2002-06-13 2016-01-05 Guided Delivery Systems, Inc. Delivery devices and methods for heart valve repair
US9468528B2 (en) 2002-06-13 2016-10-18 Guided Delivery Systems, Inc. Devices and methods for heart valve repair
US20050107811A1 (en) * 2002-06-13 2005-05-19 Guided Delivery Systems, Inc. Delivery devices and methods for heart valve repair
US8287557B2 (en) 2002-06-13 2012-10-16 Guided Delivery Systems, Inc. Methods and devices for termination
US20050107812A1 (en) * 2002-06-13 2005-05-19 Guided Delivery Systems, Inc. Delivery devices and methods for heart valve repair
US20060122633A1 (en) * 2002-06-13 2006-06-08 John To Methods and devices for termination
US8641727B2 (en) 2002-06-13 2014-02-04 Guided Delivery Systems, Inc. Devices and methods for heart valve repair
US20100082098A1 (en) * 2002-06-13 2010-04-01 Starksen Niel F Delivery devices and methods for heart valve repair
US10092402B2 (en) 2002-06-13 2018-10-09 Ancora Heart, Inc. Devices and methods for heart valve repair
US20040243227A1 (en) * 2002-06-13 2004-12-02 Guided Delivery Systems, Inc. Delivery devices and methods for heart valve repair
US20080294177A1 (en) * 2002-06-13 2008-11-27 Guided Delivery Systems Inc. Methods and devices for termination
US10624741B2 (en) 2002-06-13 2020-04-21 Ancora Heart, Inc. Delivery devices and methods for heart valve repair
US10898328B2 (en) 2002-06-13 2021-01-26 Ancora Heart, Inc. Devices and methods for heart valve repair
US20080051837A1 (en) * 2002-06-13 2008-02-28 John To Methods and devices for termination
US20080234728A1 (en) * 2002-06-13 2008-09-25 Guided Delivery Systems, Inc. Devices and methods for heart valve repair
US8287561B2 (en) * 2002-06-28 2012-10-16 Boston Scientific Scimed, Inc. Balloon-type actuator for surgical applications
US20040002726A1 (en) * 2002-06-28 2004-01-01 George Nunez Balloon-type actuator for surgical applications
US20050165380A1 (en) * 2002-11-08 2005-07-28 Kochamba Family Trust Cutaneous Injection Delivery Under Suction
US20070010810A1 (en) * 2002-11-08 2007-01-11 Kochamba Gary S Ablation and micro-needles
US20060264926A1 (en) * 2002-11-08 2006-11-23 Kochamba Gary S Cutaneous stabilization by vacuum for delivery of micro-needle array
US20070088348A1 (en) * 2002-11-08 2007-04-19 Medical Microdevices, Inc. Stabilization by suction using micro-needles
US20040092875A1 (en) * 2002-11-08 2004-05-13 Kochamba Gary Steven Cutaneous injection delivery under suction
US6896666B2 (en) * 2002-11-08 2005-05-24 Kochamba Family Trust Cutaneous injection delivery under suction
US7758637B2 (en) 2003-02-06 2010-07-20 Guided Delivery Systems, Inc. Delivery devices and methods for heart valve repair
US20050065550A1 (en) * 2003-02-06 2005-03-24 Guided Delivery Systems, Inc. Delivery devices and methods for heart valve repair
US8287555B2 (en) 2003-02-06 2012-10-16 Guided Delivery Systems, Inc. Devices and methods for heart valve repair
US20080234815A1 (en) * 2003-09-04 2008-09-25 Guided Delivery Systems, Inc. Devices and methods for cardiac annulus stabilization and treatment
US7922762B2 (en) 2003-09-04 2011-04-12 Guided Delivery Systems Inc. Devices and methods for cardiac annulus stabilization and treatment
US8343173B2 (en) 2003-09-04 2013-01-01 Guided Delivery Systems Inc. Delivery devices and methods for heart valve repair
US20050055087A1 (en) * 2003-09-04 2005-03-10 Guided Delivery Systems, Inc. Devices and methods for cardiac annulus stabilization and treatment
US20080234704A1 (en) * 2003-09-04 2008-09-25 Guided Delivery Systems, Inc. Delivery devices and methods for heart valve repair
US7753924B2 (en) 2003-09-04 2010-07-13 Guided Delivery Systems, Inc. Delivery devices and methods for heart valve repair
US7753922B2 (en) * 2003-09-04 2010-07-13 Guided Delivery Systems, Inc. Devices and methods for cardiac annulus stabilization and treatment
US20080051810A1 (en) * 2003-12-19 2008-02-28 John To Devices and methods for anchoring tissue
US20080051832A1 (en) * 2003-12-19 2008-02-28 John To Devices and methods for anchoring tissue
US20080058868A1 (en) * 2003-12-19 2008-03-06 John To Devices and methods for anchoring tissue
US20070027454A1 (en) * 2004-05-12 2007-02-01 Modesitt D B Access and closure device and method
US20070032802A1 (en) * 2004-05-12 2007-02-08 Modesitt D B Access and closure device and method
US20070027455A1 (en) * 2004-05-12 2007-02-01 Modesitt D B Access and closure device and method
US8012168B2 (en) 2004-05-12 2011-09-06 Arstasis, Inc. Access and closure device and method
US8002792B2 (en) 2004-05-12 2011-08-23 Arstasis, Inc. Access and closure device and method
US8002791B2 (en) 2004-05-12 2011-08-23 Arstasis, Inc. Access and closure device and method
US20070032803A1 (en) * 2004-05-12 2007-02-08 Modesitt D B Access and closure device and method
US20070032804A1 (en) * 2004-05-12 2007-02-08 Modesitt D B Access and closure device and method
US20050267520A1 (en) * 2004-05-12 2005-12-01 Modesitt D B Access and closure device and method
US7998169B2 (en) 2004-05-12 2011-08-16 Arstasis, Inc. Access and closure device and method
US8002793B2 (en) 2004-05-12 2011-08-23 Arstasis, Inc. Access and closure device and method
US8092477B2 (en) * 2004-05-13 2012-01-10 Umc Utrecht Holding B.V. Device for making a cut in a tissue
US20050256536A1 (en) * 2004-05-13 2005-11-17 Grundeman Paul F Device for making a cut in a tissue
US8083767B2 (en) 2005-05-12 2011-12-27 Arstasis, Inc. Access and closure device and method
US8241325B2 (en) 2005-05-12 2012-08-14 Arstasis, Inc. Access and closure device and method
US20070106246A1 (en) * 2005-05-12 2007-05-10 Modesitt D B Access and closure device and method
US8002794B2 (en) 2005-05-12 2011-08-23 Arstasis, Inc. Access and closure device and method
US20090318889A1 (en) * 2005-05-12 2009-12-24 Arstasis, Inc. Access and closure device and method
US20060271078A1 (en) * 2005-05-12 2006-11-30 Modesitt D B Access and closure device and method
US20080177380A1 (en) * 2007-01-19 2008-07-24 Starksen Niel F Methods and devices for heart tissue repair
US20090157219A1 (en) * 2007-05-03 2009-06-18 Parker Jr Lance T Intelligent Sleeve Container for Use in a Controlled Syringe System
US20080287875A1 (en) * 2007-05-16 2008-11-20 Ecole Polytechnique Federale De Lausanne (Epfl) Infusion pump with phase separator
US8034027B2 (en) * 2007-05-16 2011-10-11 Ecole Polytechnique Federale De Lausanne (EPPL) Infusion pump with phase separator
US20090082730A1 (en) * 2007-09-24 2009-03-26 Li Nguyen Needle injection assembly
US20090105744A1 (en) * 2007-10-17 2009-04-23 Modesitt D Bruce Methods for forming tracts in tissue
US20090234318A1 (en) * 2007-10-19 2009-09-17 Guided Delivery Systems, Inc. Systems and methods for cardiac remodeling
US9125632B2 (en) 2007-10-19 2015-09-08 Guided Delivery Systems, Inc. Systems and methods for cardiac remodeling
US20090173391A1 (en) * 2008-01-08 2009-07-09 Pradip Choksi Adjustable pressure relief valve
US7721763B2 (en) 2008-01-08 2010-05-25 Pradip Choksi Adjustable pressure relief valve
US20090222083A1 (en) * 2008-02-06 2009-09-03 Guided Delivery Systems Inc. Multi-window guide tunnel
US12082813B2 (en) 2008-02-06 2024-09-10 Ancora Heart, Inc. Multi-window guide tunnel
US20100094248A1 (en) * 2008-02-06 2010-04-15 Guided Delivery Systems Inc. Multi-window guide tunnel
US8790367B2 (en) 2008-02-06 2014-07-29 Guided Delivery Systems Inc. Multi-window guide tunnel
US9706996B2 (en) 2008-02-06 2017-07-18 Ancora Heart, Inc. Multi-window guide tunnel
US10542987B2 (en) 2008-02-06 2020-01-28 Ancora Heart, Inc. Multi-window guide tunnel
US20100016796A1 (en) * 2008-03-25 2010-01-21 Animal Innovations, Inc. Syringe Mechanism for Detecting Syringe Status
US20100016810A1 (en) * 2008-07-21 2010-01-21 Arstasis. Inc., Devices and methods for forming tracts in tissue
US20100016786A1 (en) * 2008-07-21 2010-01-21 Arstasis, Inc. Devices, methods, and kits for forming tracts in tissue
US8979882B2 (en) 2008-07-21 2015-03-17 Arstasis, Inc. Devices, methods, and kits for forming tracts in tissue
US9636106B2 (en) 2008-10-10 2017-05-02 Ancora Heart, Inc. Termination devices and related methods
US8795298B2 (en) 2008-10-10 2014-08-05 Guided Delivery Systems Inc. Tether tensioning devices and related methods
US20110125178A1 (en) * 2009-05-15 2011-05-26 Michael Drews Devices, methods and kits for forming tracts in tissue
US20110208215A1 (en) * 2009-09-22 2011-08-25 Modesitt D Bruce Devices, methods, and kits for forming tracts in tissue
US20110172589A1 (en) * 2010-01-11 2011-07-14 Kenneth Finkelstein Surgical instrument having an integrated local anesthetic delivery system
US9277936B2 (en) * 2010-01-11 2016-03-08 Kenneth Finkelstein Surgical instrument having an integrated local anesthetic delivery system
US8480621B2 (en) * 2010-03-21 2013-07-09 Mania Landman Device and method for injecting fluids or gels
US20110230833A1 (en) * 2010-03-21 2011-09-22 Mania Landman Device and Method for Injecting Fluids or Gels
US9861350B2 (en) 2010-09-03 2018-01-09 Ancora Heart, Inc. Devices and methods for anchoring tissue
US10675447B2 (en) 2012-05-25 2020-06-09 Arstasis, Inc. Vascular access configuration
US10441753B2 (en) 2012-05-25 2019-10-15 Arstasis, Inc. Vascular access configuration
US10493200B2 (en) * 2015-02-27 2019-12-03 E-Wha Meditech Inc. Medical fluid injector and medical fluid supply device including same
US20180028744A1 (en) * 2015-02-27 2018-02-01 E-Wha Meditech Inc. Medical fluid injector and medical fluid supply device including same
US10980973B2 (en) 2015-05-12 2021-04-20 Ancora Heart, Inc. Device and method for releasing catheters from cardiac structures
US11964112B2 (en) 2015-05-12 2024-04-23 Ancora Heart, Inc. Device and method for releasing catheters from cardiac structures
WO2017147722A1 (en) 2016-02-29 2017-09-08 Medicel Ag Injection and/or aspiration device, in particular for ejecting and/or aspirating of a gas and/or a liquid
US10667914B2 (en) 2016-11-18 2020-06-02 Ancora Heart, Inc. Myocardial implant load sharing device and methods to promote LV function
USD824509S1 (en) * 2016-12-19 2018-07-31 University Of The Free State Inoculator
US20190343502A1 (en) * 2016-12-30 2019-11-14 Advanced Medical Solutions Limited Adhesive applicator
US10874383B2 (en) * 2016-12-30 2020-12-29 Advanced Medical Solutions Limited Adhesive applicator
WO2019169408A1 (en) * 2018-03-02 2019-09-06 Somnus Medical, LLC Iv set or iv set system with unidirectional access port
US11672524B2 (en) 2019-07-15 2023-06-13 Ancora Heart, Inc. Devices and methods for tether cutting
US12257151B2 (en) 2020-04-17 2025-03-25 Ancora Heart, Inc. Myocardial implant load sharing device and methods to promote LV function

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BE783318A (en) 1972-11-10
IL39327A0 (en) 1972-07-26
CA982006A (en) 1976-01-20
ZA723178B (en) 1973-12-19
ES402388A1 (en) 1975-11-01
DE2223373A1 (en) 1972-11-23
IT961297B (en) 1973-12-10
AR192775A1 (en) 1973-03-14
NL7205597A (en) 1972-11-15
AU458486B2 (en) 1975-02-27
AU4178872A (en) 1973-12-20
LU65344A1 (en) 1972-08-23
CH540699A (en) 1973-08-31
IL39327A (en) 1974-12-31
GB1335797A (en) 1973-10-31
FR2137865A1 (en) 1972-12-29

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