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US3050061A - Parenteral solution equipment - Google Patents

Parenteral solution equipment Download PDF

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Publication number
US3050061A
US3050061A US66236157A US3050061A US 3050061 A US3050061 A US 3050061A US 66236157 A US66236157 A US 66236157A US 3050061 A US3050061 A US 3050061A
Authority
US
United States
Prior art keywords
vial
container
stopper
parenteral solution
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
Other languages
English (en)
Inventor
Leonard F Goyke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter International Inc
Original Assignee
Baxter Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Laboratories Inc filed Critical Baxter Laboratories Inc
Priority to US66236157 priority Critical patent/US3050061A/en
Priority to GB2674058A priority patent/GB884078A/en
Priority to FR1209627D priority patent/FR1209627A/fr
Priority to BE570564D priority patent/BE570564A/fr
Application granted granted Critical
Publication of US3050061A publication Critical patent/US3050061A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2068—Venting means
    • A61J1/2072—Venting means for internal venting

Definitions

  • This invention relates to parenteral solution equipment and the use thereof, and more particularly to equipment useful in supplementing bulk parenteral solutions.
  • the bulk parenteral solutions to which this invention is directed are usually considered to be solutions in excess of 250 cc. Most usually, these solutions are provided in sizes of 250 cc., 500 cc., and 1000 cc. Depending upon the quantity of the solution and the requirements of the patient, the administration of these solutions may vary over a period from about one hour to as much as eight hours.
  • the administration is usually achieved by a length of tubing communicated at one end with a parenteral solution bottle mounted mouth-downwardly and at the other end with a needle inserted under the skin of an intended recipient.
  • Suitable flow-regulating means are associated with the administration set, usually a drip-meter and clamp for the tubing so as to permit dropwise administration of the parenteral solution.
  • parenteral solutions are often thought of in terms as a source of intravenous feeding, they are by no means limited to providing nutriment. They have been found useful in maintaining the recipient against shock, such as attends the loss of blood during surgery. They have been used to maintain the salt level of the blood in this connection. They have also been used as carriers for anesthetics and other associated medicines.
  • parenteral solutions permit them to act as carriers for a wide variety of medicines. It is to be appreciated, however, that because of their bulk, a wide variety of parenteral solutions cannot be conveniently stored, even in hospitals of considerable size. Thus, it is not uncommon for parenteral solutions of a basic nature, such as glucose or saline, to be supplemented by a particular medicine just prior tothe administration of the bulk parenteral solution. I have noted reports that show that in as many as one in every four administrations, the basic solution has been supplemented by one type of medicine or another. This is particularly the case in the use of certain preparations such as vitamins that are unstable as water solutions.
  • a basic nature such as glucose or saline
  • FIGURE 1 is a cross-sectional view of a bulk parenteral solution container in communication with an additive vial; and FIG. 2 is an elevational view, partially in section, similar to FIG. 1 but showing the structure of FIG. 1 in a different operative condition.
  • Container 10 denotes generally a parenteral solution container.
  • Container 10 includes a glass bottle 11 provided with an annular groove or recess 12 adjacent the bottom thereof.
  • band 13 Mounted on bottle 11 within recess 12 is band 13.
  • bail 14 Attached to lugs or ears 13a of band 13 is bail 14 (seen only in FIG. 2). Bail 14 and band 13 cooperate to provide a convenient means for suspending bottle 11 in a mouth-downward fashion, such as is shown in FIG. 1, and which is the position employed during dispensing of liquid from parenteral solution container 10.
  • Bottle 11 is provided with a mouth 15 into which is inserted stopper 16.
  • stopper 16 is constructed of a resilient material such as rubber or rubber substitutes.
  • Stopper 16 is provided with an annular flange portion 17 which overlies the top lip of bottle 11.
  • Stopper 16 is maintained in place in the neck 15 of bottle 11 by a clamping ring 18 which is anchored to an annular bead 11a provided in the external wall of bottle 11.
  • Overlying stopper 16 is a frangible diaphragm 19.
  • Extending through stopper 16 are passages 20 and 21. Mounted within passage 20 and extending inwardly of bottle 11, is an air tube 22.
  • the numeral 24 designates generally an additive vial structure which embodies teachings of this invention.
  • Vial 24 like bottle 11, can be conveniently constructed of glass.
  • Vial 24 is equipped with a top closure 25 which, in the illustration given, is shown secured to vial 24 in a manner similar to the securement of stopper '16 to bottle 11.
  • vial stopper 25 is provided with an annular flange 25a which overlies the top lip of vial 24. Stopper 25 is maintained in place by a clamping ring 26 which is anchored to vial 24 under an annular bead 24a.
  • Passages 27 and 28 are spaced apart a distance approximately the same as the separation of passages 20 and 21 in stopper 16.
  • Fitting 27a extends outwardly of vial 24 and is shown inserted into passage 21 of stopper 16 of parenteral solution container 10.
  • fitting 29 is of a length sufficient to extend into air tube 22 when fitting 27a is inserted into passage 21 and in communication with parenteral solution 23.
  • Fitting 29 is provided with a tight fitting annular sleeve 30 which terminates a distance spaced from the end of puncture fitting 29.
  • sleeve 30 is constructed of a resilient material such as rubber, in which case it can act as a seal in cooperation with stopper 16 or diaphragm 19, as the case may be.
  • vial 24 and container 10 provide a closed system, i.e., a system in which no contact with unsterile outside air is permitted.
  • fitting 27a is pressed-fitted into passage 21 of stopper 16 so as to effectively seal air from entering container 10 through passage 21.
  • the abutment of sleeve 30 against the top surface of stopper 16 likewise prevents entry of unsterile air into parenteral solution container 10.
  • FIG. 1 When it is desired to supplement parenteral solution 23 with a solid medicament, the arrangement shown in FIG. 1 is first employed.
  • vial 24 and container 10 are communicated by virtue of having fittings 27a and 29 inserted into passageways 21 and 20, respectively.
  • the coupled or communicated vial 24 and container 10 are disposed in the position shown in FIG. 1, wherein container 10 is uppermost and positioned in a mouth-downward condition.
  • solution 23 flows out of container 10 through passage 21 and through fitting 27a into vial 24 to come in contact with the solid medica ment container in vial 24.
  • particles 32 of solid medicament contained within vial 24 are shown in a state prior to solution or dispersion within solution 23.
  • the structure and method of this invention permits the supplementation of bulk parenteral solutions with a minimum of manipulation. All that is required is coupling of a medicamentcontaining vial to a parenteral solution bottle. This is achieved by thrusting fittings 27a and 29 into passageways 21 and 20, respectively, when container 10 is positioned mouth-downwardly, as seen in FIG. 1. Flow of liquid out of container 10 is prevented by virtue of diaphragm 19 closing passages and 21. Alternatively, it is possible to couple vial 24 to container 10 when the latter is positioned as shown in FIG. 2, i.e., mouth-up- Ward. This has been found particularly convenient when vial 24 contains a solid medicament, since a solid medicament does not have a tendency to flow out of vial 24.
  • liquid solution 23 from container 10 flows into vial 24, diluting or dissolving the medicament contained in vial 24 and effectively making it possible to transfer all of the medicament into container 10. Thereafter, inversion of the coupled container and vial to the condition shown in FIG. 2 efiectuates transfer of the supplemental medication.
  • a parenteral solution container equipped with a resilient stopper, said stopper having a pair of passages therein adapted to communicate the interior of said container with the exterior of said stopper, an air tube mounted in one of said passages and extending only inwardly of said container and to a point adjacent the bottom of said container, a vial containing a supplemental medicament for the container solution, a closure secured to said vial, said closure being equipped with a pair of spaced apart spouts of equal length extending only outwardly of the portion of said closure connected to said vial, said spouts having passages extending there through, both of said spouts being of generally circular cross-section and one spout being of smaller outer diameter than the other, the smaller outer diameter spout being received in the air tube-equipped passage of said stopper, the larger outer diameter spout being received in the other passage of said stopper, the smaller diameter spout being equipped with resilient means in sealing en gagement with said stopper.
  • a parenteral solution container equipped with a resilient stopper, said stopper having a pair of passages therein adapted to communicate the interior of said container with the exterior of saidstopper, an air tube mounted in one of said passages and extending only inwardly of said container and to a point adjacent the bottom of said container, a vial containing a supplemental medicament for the container solution, a closure secured to said vial, said closure being equipped with a pair of spaced apart, outwardly extending tubular spouts disposed in generally parallel relation, one of said spouts being of larger outer diameter than the other, the larger outer diameter spout being in sealing engagement with the Walls of the passage of said stopper other than the passage equipped with said air tube, the smaller diameter spout being mounted in the air tube-equipped passage of said stopper, and sealing means about said smaller diameter spout interposed between said spout and said stopper.
  • a device for coupling engagement with said container comprising a medicament-containing vial and a closure for said vial, said closure having a pair of parallel, spacedapart, outwardly extending, tubular, puncturing spouts having passages extending therethrough, said spouts being of unequal outside diameter, the outside diameter of the larger of said spouts being about equal in size to the inside diameter of said outlet passage and the outside diameter of the smaller of said spouts being less than the inside diameter of said air tube, said smaller spout being equipped with an annular resilient sleeve extending along the length therefo but, terminating a spaced distance from the tip of said spout so that when said device is in coupling engagement with said parenteral solution container, the spout of smaller outside diameter extends into said air tube and the resilient annular sleeve cooperates

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
US66236157 1957-05-29 1957-05-29 Parenteral solution equipment Expired - Lifetime US3050061A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US66236157 US3050061A (en) 1957-05-29 1957-05-29 Parenteral solution equipment
GB2674058A GB884078A (en) 1957-05-29 1958-08-20 Parenteral solution equipment and use thereof
FR1209627D FR1209627A (fr) 1957-05-29 1958-08-21 Procédé et appareillage pour la manipulation de solutions injectables par voie parentérale
BE570564D BE570564A (fr) 1957-05-29 1958-08-22

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US66236157 US3050061A (en) 1957-05-29 1957-05-29 Parenteral solution equipment

Publications (1)

Publication Number Publication Date
US3050061A true US3050061A (en) 1962-08-21

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Family Applications (1)

Application Number Title Priority Date Filing Date
US66236157 Expired - Lifetime US3050061A (en) 1957-05-29 1957-05-29 Parenteral solution equipment

Country Status (4)

Country Link
US (1) US3050061A (fr)
BE (1) BE570564A (fr)
FR (1) FR1209627A (fr)
GB (1) GB884078A (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3216418A (en) * 1962-06-01 1965-11-09 Abbott Lab Apparatus for administering parenteral solutions
US3512806A (en) * 1968-01-22 1970-05-19 Russell H Romney Adapter for multiple connections to intravenous fluid receptacles and the like
US4244467A (en) * 1978-06-05 1981-01-13 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Device for the extemporaneous preparation of a solution under sterile conditions
US20100275786A1 (en) * 2007-10-16 2010-11-04 Peter Brezovnik Beverage dispenser with cohesive sealing part at the tap unit
WO2011092513A3 (fr) * 2010-01-29 2011-09-29 Innovate Uk Limited Ensemble de distribution d'un médicament fluide et procédé
WO2017107704A1 (fr) * 2015-12-22 2017-06-29 成都杰仕德科技有限公司 Mécanisme de composition de médicament intégré et procédé de composition de médicament pour flacon de poudre pour injection
EP3772374A1 (fr) * 2019-08-06 2021-02-10 Celldynamics I.s.r.l. Connexion de flacon stérile

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1210716B (de) * 1961-03-24 1966-02-10 Theodor Kovacs Behaelter zum Fuellen von Tintenpatronen fuer Fuellfederhalter
US4303071A (en) * 1978-08-07 1981-12-01 Baxa Corporation Syringe-type liquid container dispenser adapter
US4936829A (en) * 1988-10-19 1990-06-26 Baxter International Inc. Drug delivery apparatus including beneficial agent chamber with chimney for a directed flow path
GB2247451B (en) * 1990-08-30 1994-06-22 Dominic James Robinson Liquid transfer system
DE4105147A1 (de) * 1991-02-20 1992-08-27 Draegerwerk Ag Fuellvorrichtung fuer narkosemittelverdunster
IT1269700B (it) * 1994-01-07 1997-04-15 Abbott Lab Sistema e apparecchiatura per collegare un contenitore di anestetico ad un vaporizzatore
GB2314322A (en) * 1996-06-21 1997-12-24 Merck & Co Inc Deflected septum seal access port
US5882601A (en) * 1997-06-18 1999-03-16 Merck & Co., Ltd. Deflected septum seal access port

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1526595A (en) * 1922-08-21 1925-02-17 Gillman George Blood-extracting device
US2202163A (en) * 1936-06-15 1940-05-28 Nat Drug Co Closure for dispensing containers
FR971839A (fr) * 1948-09-20 1951-01-22 Dispositif pour manipuler un liquide à l'abri de l'air extérieur
US2580836A (en) * 1947-04-21 1952-01-01 Associated Drug Ind Inc Intravenous solution technique and apparatus
US2612163A (en) * 1950-10-09 1952-09-30 Wilson Y Norman Container for hypodermic preparations
US2689564A (en) * 1951-11-29 1954-09-21 Becton Dickinson Co Blood donor assembly
US2704544A (en) * 1954-07-02 1955-03-22 Venoclysis equipment
FR1122616A (fr) * 1955-02-24 1956-09-11 Perfectionnements apportés aux dispositifs pour le transvasement d'une substance liquide ou pulvérulente, notamment d'une substance thérapeutique
US2863451A (en) * 1955-01-10 1958-12-09 Sr Courtland H Barr Blood transfusion assembly
US2884924A (en) * 1956-07-25 1959-05-05 American Sterllizer Company Drip meter

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1526595A (en) * 1922-08-21 1925-02-17 Gillman George Blood-extracting device
US2202163A (en) * 1936-06-15 1940-05-28 Nat Drug Co Closure for dispensing containers
US2580836A (en) * 1947-04-21 1952-01-01 Associated Drug Ind Inc Intravenous solution technique and apparatus
FR971839A (fr) * 1948-09-20 1951-01-22 Dispositif pour manipuler un liquide à l'abri de l'air extérieur
US2612163A (en) * 1950-10-09 1952-09-30 Wilson Y Norman Container for hypodermic preparations
US2689564A (en) * 1951-11-29 1954-09-21 Becton Dickinson Co Blood donor assembly
US2704544A (en) * 1954-07-02 1955-03-22 Venoclysis equipment
US2863451A (en) * 1955-01-10 1958-12-09 Sr Courtland H Barr Blood transfusion assembly
FR1122616A (fr) * 1955-02-24 1956-09-11 Perfectionnements apportés aux dispositifs pour le transvasement d'une substance liquide ou pulvérulente, notamment d'une substance thérapeutique
US2884924A (en) * 1956-07-25 1959-05-05 American Sterllizer Company Drip meter

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3216418A (en) * 1962-06-01 1965-11-09 Abbott Lab Apparatus for administering parenteral solutions
US3512806A (en) * 1968-01-22 1970-05-19 Russell H Romney Adapter for multiple connections to intravenous fluid receptacles and the like
US4244467A (en) * 1978-06-05 1981-01-13 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Device for the extemporaneous preparation of a solution under sterile conditions
US20100275786A1 (en) * 2007-10-16 2010-11-04 Peter Brezovnik Beverage dispenser with cohesive sealing part at the tap unit
WO2011092513A3 (fr) * 2010-01-29 2011-09-29 Innovate Uk Limited Ensemble de distribution d'un médicament fluide et procédé
WO2017107704A1 (fr) * 2015-12-22 2017-06-29 成都杰仕德科技有限公司 Mécanisme de composition de médicament intégré et procédé de composition de médicament pour flacon de poudre pour injection
EP3772374A1 (fr) * 2019-08-06 2021-02-10 Celldynamics I.s.r.l. Connexion de flacon stérile
WO2021023546A1 (fr) * 2019-08-06 2021-02-11 Celldynamics Isrl Raccordement stérile de flacons

Also Published As

Publication number Publication date
BE570564A (fr) 1958-09-15
GB884078A (en) 1961-12-06
FR1209627A (fr) 1960-03-02

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