US2580836A - Intravenous solution technique and apparatus - Google Patents

Description

Jan. 1, 1952 R, R RAUSCH 2,580,836

INTRAVENOUS SOLUTION TECHNIQUE AND APPARATUS Filed April 2l, 1947 2 'SHEETS-SHEET l ,il Il /Z f /o 9 f' Y Y ATTORNEYS Jam 1,11952 R. R. RAUscH f 25805836 Y INTRAVENOUS SOLUTION TECHNIQUE AND APPARATS Filed April 2l, 1947 2 Sl'lEETS-vSl-IEET -2 ATTORNEYS Tlc-4- f Patented Jan. 1, 1952 INTRAVENOUS SOLUTION TECHNIQUE AND APPARATUS Roy R. Rausch, Farmington, Mich., assignor to Associated Drug Industries, Inc., Cleveland,

Ohio, a corporation Application April 21, 1947, Serial No. 742,915

3 Claims.

(Cl. 12S- 272) My present invention relates primarily to the l art of packaging intravenous solutions for parenteral administration.

In the carrying out of my invention I utilize novel container apparatus Vinvolving the use of the common relatively large bottle or ilask for holding the bulk liquid or Water constituent of the ultimate intravenous fluid, and separate container means for holding the chemical or medicinal ingredient which is customarily admixed with the sterilized distilled water above referred My invention involves primarily novel features of the construction of the respective flask and its associated smaller container as mentioned above, whereby the two receptacles may be employed initially for the separate containing of the constituents of the parenteral fluid, and whereby they may be combined for the purpose of bringi-ng the said constituents together or mixing them just previous to the time that they are required to be used.

A special novel feature of my invention lies in the provision of peculiar sealing means for the larger flask containing the sterile distilled water commonly used, which sealing means is of a nature such that it may be broken incidental to the union of the said ask with the bottle or small container of the chemical or medicinal ingredient of the ultimate solution in the operation of combining the constituents of the solution at the time of use.

A full understanding of my invention and the merits thereof will be had upon reference to the following detail description including the technique of the operations employed in connection with the accompanying drawings, in which:

Figure 4 is a view in elevation of the combined container features of my invention as they are assembled when in actual use.

Figure 5 is a view similar to Figure 2 but illustrating a slightly modied form of auxiliary container particularly suitable for receiving the chemical or medicinal ingredient of the parenteral solution, in powedered or liquid condition.

Figure 6 is a fragmentary view of a modification of my invention.

I rst refer to Figure l of the drawing which shows the form of my main flask or container designed to hold the distilled water or similar ingredient of an intravenous solution. This container, generally designated I, is a flask of known construction, of relatively large volume, having the screw neck portion 2 and the bottom outlet 3, the latter adapted to be closed and sealed by a rubber closure denoted 4. Applied to the screw neck portion 2 of the ilask I is a special form of closure means including a reducing type coupling cap or closure member 5, the latter having the internally threaded depending skirt portion 6, and the central upwardly projecting tubular extension 'I of a diameter much less than that of the body of the closure 5. The extension 7 is internally threaded to permit it to receive lthe screw threaded portion of the closure cap 8, and the closure member 5 is formed with a central web 9 intermediate the parts 'I and 6,

. which web is centrally apertured as shown at Il.

Figure 1 is a vertical sectionalI view showing rflask and auxiliary container after they have been connected together, and illustrating the manner in which the auxiliary container is utilized to break the seal closing the main .ask,

the latter being broken 'away at its lower portion.. y

Intermediate the lower end of the cap member 8 and the upper surface of the web 9 of the closure member 5 is a disc-like sealing member Il which may be made of very thin tin, plastic substance, or any other substance suitable for the purposes of my invention. A gasket I2 is interposed between the upper end of the neck portion 2of the ask i and the portion of the closure member 5 just above such end of the neck. This gasket permits of establishing an air-tight connection between the members I and 5 when the latter is screwed tightly upon the neck of the flask, and the seal II likewise affords an airtight sealing means for the opening Ill beneath the cap 8.

I now refer to Figure 2 of the drawing which illustrates my auxiliary container to be used in `conjunction with the main flask I, the latter ordinarily holding the sterile distilled Water 'constituent of the ultimate solution. The auxiliary container is designated I3 and comprises a relatively small body having at its upper end a reduced threaded neck portion I4, the latter being formed with a closure portion I5 from which kprocess is concluded, the closing seal I8 is approjects at the center thereof the tubular extension I6 having the aperture I'I therethrough.

For closing the combined inlet and outlet opening II of the auxiliary container I3 in an air-tight manner, I provide a sealing disk I8 adapted to be seated upon the upper or outer end of the portion I'6 above mentioned,"said discbeing employed in conjunction with the closure member I9 in the form of a round or suitably shaped cap having internal screw threads whereby it may be screwed uponl the threaded portion of the neck I4 of the container I3. The container I3 is adapted to contain the medicinal or chemical ingredient f the Vvultimate intravenous solution which isto :be administered to a patient as the nal parenteral solution, and the form of the container I3 is such thatlit will readily contain such particular ingredient, as for instance concentrated saline solution, V'dextrose solution, combina-tion dextrose and saline solution, amino acid solution, or ma'ny other medicinal'or chemical ingredients in liquidifo'rm.

Figure shows anwauxiliary container which is practically the same in construction as that of Figure 2, except ythat the-'neck portion of the container is somewhat differently vformed :in order to provide a tapering or-inclined wall outlet portion leadingto the apertured tubular outlet extension or nipple portion Ia. The container of Figure 5 is especiallyadaptedfor receiving the chemical or medicinal ingredient for admixture with the water in the iiask I when such ingredient is in powdered form, as for instance of the character of protein-hydrolysate powders which contain amino acid.

With the foregoing understanding of the construction of the dual container apparatus of `my invention, in respect to the specic construction of each of the flask and auxiliary container parts, I nowproceed to describe. the manner of use of the container apparatus asV abovefset forth.

The ask I with the closure 4 applied toits lower discharge portion 3, fand containing the requisite amount of distilled water therein as indicated by centimeter indicia onthe outside of the flask, and while the flask-is open'iat the neck portion 2,is placed inthe usualrautoclave and sterilized after the usual technique. Upon removal from the autoclave, the closure means for the ask, including the parts 5 and 8, andthe sealing disc II, is immediately applied to Hthe neck portion 2 of the flask by screwing the closure member 5 at its internally threaded portion upon the screw threads of the neck 2. The vflask I and its contents are then permitted to cool, and in this manner a vacuum is createdin the space within the flask unoccupied by its liquid contents. The flask is now fully vsealed and ready for ti'ansportation to its place of use with the distilled water therein.

In like manner it is contemplated to accomplish the sterilization of the auxiliary container I3 and the chemicalcompound disposedth'ein, whatever that compound Ymay be, dependent upon the particular use for which the Vparenteral uid is to be employed. With 'its chemical contents therein, therefore, the containerl3 will be -placed in an autoclave while the container is open at the opening I'I. After the ste'rilizing piieoi to uio portion 'I5 of the container I3 to" seal the opening I1, and the cap or closure mein- `ber I9-is then screwed inplace on the -upper endof the said container I3. The container I3 its use.

It is obvious that the hospital or physician may keep on hand a large number of the auxiliary containers I3 properly labelled to indicate the particular chemical content or other ingredient for the parenteral solution which is to be mixed with the distilled water in the flask I, just prior to the administering `of the 'intraven- -ous-soluticniby-tubulatingflask -I 'at the outflow and coupling member 3.

The admixing of the compound in the auxiliary .container I3 with the sterilized contents of -`the flask I Ywill be effected in the following manner: Assuming that the person who is about to use the @parenteral solution wishes to administer theis'ame;'promp'tly, he will rst partially unscrew thew'zlo'si'ne 'member 5 from the neck portion 2 of uthe ask I, slightly releasing the tightness of the threaded connection between the parts 5 and `Zand -thereby opening the interior of the ask to atmospheric pressure. This will release the vacuum yin the .iiask I in the customary way. Thereupon, a f selected one of these -auxiliary containers I3 will be employed, dependent'upon theina'ture 'of the'contents thereof and the desired type of intravenoussolution which -.is to be administered. lThe cap closure V'8 having been now vremoved from the closure 'member 5 .of'the /flask EI,'the capclosure YI9 ofthe auxiliary container 44I3 is removed therefrom along with-the sealv I8, andfsaid container I'3-is invertedfandin such.' position -is-screwed at its'neck portion into the tubular extension 1 of the closure member'i5 after the manner illustrated inFigureiS of the drawings. The flask or vessel vI has meanwhile Vremained sealed by means of the seal II previouslydescribed. However, upon the application of -the auxiliary container I-3 to the iiask Iiin the 'manner Ashown in Figure 3, it will 4become apparent--thatthe screwing Aaction of the neck 'I4 of thecontainer I3, into the portion -1 yof the lclosure member 5 -will cause the tapering nipple or tubular extension I6 of the part I5-to engage thecentral portion ofthe sealing .member in themanner shown in Figure 3, thereby rupturing .orpuncturing lthesealing member, which permits the contentsof the-.auxiliary container I3,con sistingof `.the .required chemical compound or Aconcentrated chemical solution, to passer` gravi- /tate downintotheask I--and.become mixedwith the contents of the latter. This mixing maybe facilitated by means'of agitatiomif so desired.

If the container I3a of themodied construc- -tion shownin 'Figure 5 kis employed, the chemical vcompound-in vthis-container I-3a in powderedor liquidicondition will, likewise passtothe ila'sk or Vessel I -b y` theA inverting operation and connection between the auxiliary container and 'ilask Iin the vmanner above described.

Theoperation of administering the intravenous solutionis generally illustrated in 'Figure 4,'in `whichthefiask I isfshownmas having the administering i tube applied to the Vdischarge portion i 3 thereof, said tube 2 I being equipped with the usual injection needle at its lower end. The apparatus as seen in the condition of Figurel will be-susceptible of being suspended at a suitable elevation, for thel administering process, by means Y of any lsuitable bail or like member 22.

It will'o'f course be understood that inthe use of my container apparatus, after the sterilizing .process 'has been performed in regard tothe con- 4tainer units "and their contents, `the customary testingto make certain'that thesolution ingre- .die'nts "are lfree from .p'yrcg'ens may be made sterility vis also assured by rigid bacteriologiccon- NtrL'as customary.

It will be apparent that there is practically no liability of contamination of the constituents of the infusion solution in the use of my invention. The flask I is sealed until the auxiliary container I3, by the screw action of the part I6, ruptures the seal. The small seal I8 of container I3 need not be removed until the container is inverted and just at the instant the neck I4 is introduced into the screw extension 'I of the closure member 5.

If desired, the vacuum in the flask I need not be released, by slightly unscrewing closure 5, until the two containers I and I3, or l and I3a, are united.

According to the modified form of my invention in Figure 6, the screw extension 1a of the member 5, and the neck I4a of container I 3b, are Vertically elongated so that, if desired, the container I3b may be ailixed to the flask I, and both sterilized, tested while together, and then sent as, a unit to the place of use. The container I3b will be sealed by the seal Il while in unruptured state. At the time of use, the container I3b will be screwed deeper into the tubular member la to establish communication between the receptacles by action of the part I6a on the seal II. There are conditions in which such construction may be advantageously utilized.

Having thus described my invention, what I claim as new and desire to secure by Letters Patent of the United States, is:

1. In intravenous solution apparatus, in combination, a main iiask having a solution introducing opening, a frangible seal on said ask disposed so as to seal said opening, a closure member detachably connected with the ask at said opening and holding said seal in place, said closure member having an opening therethrough for communication with the atmosphere and closed by the said seal. and an auxiliary container having a screw-thread connection with the closure member and formed with an apertured extension Y said seal to establish communication between the interiors of the ilask and container.

2. Apparatus as claimed in claim 1, in which the detachable connection of the closure with the flask is a screw connection, and in which the seal is clamped to the flask at its said opening by screw action of the closure against the ilask.

3. In intravenous solution apparatus, in combination, a main iiask for containing a liquid of the ultimate parenteral solution and provided with a, charging opening, an auxiliary container having a charging opening, an instrumentality connecting theopening portions of the flask and container, and a seal common to the two opening portions of the flask and auxiliary container, one of said ask and container vessels having a seal rupturing member operable to puncture the seal by relative rotation of the vessels.

ROY R. RAUSCH.

REFERENCES CITED The following references are of record in the le of this patent:

UNITED STATES PATENTS Number Name Date 1,718,593 Smith June 25, 1929 1,960,858 Strauch --.May 29, 1934 2,028,751 Barton n Jan. 28, 1936 2,176,042 Pittenger Oct. 10, 1939 2,232,978 Smith Feb. 15, 1941 2,333,898 Stevenson Nov. 9, 1943 2,388,634 De Woody Nov. 6, 1945 FOREIGN PATENTS Number Country Date 74,728 Switzerland Apr. 2, 1917 245,374 Germany Feb. 5, 1910

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