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US3045494A - Method of providing for blood count and pipette and assembly for use therein - Google Patents

Method of providing for blood count and pipette and assembly for use therein Download PDF

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Publication number
US3045494A
US3045494A US721139A US72113958A US3045494A US 3045494 A US3045494 A US 3045494A US 721139 A US721139 A US 721139A US 72113958 A US72113958 A US 72113958A US 3045494 A US3045494 A US 3045494A
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US
United States
Prior art keywords
tube
reservoir
blood
assembly
bore
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US721139A
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English (en)
Inventor
Gerarde Horace William
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Individual
Original Assignee
Individual
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Filing date
Publication date
Priority to NL135023D priority Critical patent/NL135023C/xx
Priority to NL275145D priority patent/NL275145A/xx
Application filed by Individual filed Critical Individual
Priority to US721139A priority patent/US3045494A/en
Priority to GB6103/62A priority patent/GB962356A/en
Priority to DEG34306A priority patent/DE1297361B/de
Priority to CH225462A priority patent/CH384899A/fr
Priority to FR889052A priority patent/FR1317488A/fr
Application granted granted Critical
Publication of US3045494A publication Critical patent/US3045494A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/06—Test-tube stands; Test-tube holders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150061—Means for enhancing collection
    • A61B5/150099—Means for enhancing collection by negative pressure, other than vacuum extraction into a syringe by pulling on the piston rod or into pre-evacuated tubes
    • A—HUMAN NECESSITIES
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    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150213—Venting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150236—Pistons, i.e. cylindrical bodies that sit inside the syringe barrel, typically with an air tight seal, and slide in the barrel to create a vacuum or to expel blood
    • A—HUMAN NECESSITIES
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    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150244—Rods for actuating or driving the piston, i.e. the cylindrical body that sits inside the syringe barrel, typically with an air tight seal, and slides in the barrel to create a vacuum or to expel blood
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    • A61B5/150259—Improved gripping, e.g. with high friction pattern or projections on the housing surface or an ergonometric shape
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    • A61B5/150503—Single-ended needles
    • A61B5/150519—Details of construction of hub, i.e. element used to attach the single-ended needle to a piercing device or sampling device
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    • A61B5/150534—Design of protective means for piercing elements for preventing accidental needle sticks, e.g. shields, caps, protectors, axially extensible sleeves, pivotable protective sleeves
    • A61B5/150694—Procedure for removing protection means at the time of piercing
    • A61B5/150717—Procedure for removing protection means at the time of piercing manually removed
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    • A61B5/15101—Details
    • A61B5/15103—Piercing procedure
    • A61B5/15105—Purely manual piercing, i.e. the user pierces the skin without the assistance of any driving means or driving devices
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    • A61B5/15142—Devices intended for single use, i.e. disposable
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A61M5/344—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub using additional parts, e.g. clamping rings or collets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0213—Accessories for glass pipettes; Gun-type pipettes, e.g. safety devices, pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B01L3/0224—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type having mechanical means to set stroke length, e.g. movable stops
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • B01L3/0231—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type having several coaxial pistons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L3/0279—Interchangeable or disposable dispensing tips co-operating with positive ejection means
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    • B01L3/0282—Burettes; Pipettes mounted within a receptacle
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L9/54—Supports specially adapted for pipettes and burettes
    • B01L9/543—Supports specially adapted for pipettes and burettes for disposable pipette tips, e.g. racks or cassettes
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B17/00—Sulfur; Compounds thereof
    • C01B17/69—Sulfur trioxide; Sulfuric acid
    • C01B17/90—Separation; Purification
    • C01B17/907—Removal of arsenic
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N1/02—Devices for withdrawing samples
    • G01N1/10—Devices for withdrawing samples in the liquid or fluent state
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    • G—PHYSICS
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    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples
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    • A61B5/15058—Joining techniques used for protective means
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    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B01L2300/0838—Capillaries

Definitions

  • a structure is furnished which may be produced at nominal cost. Therefore the assembly may have a one-time use, after which it is discarded. Accordingly, the danger of infection to the user, as existing with the use of conventional pipettes and assemblies, is avoided. This is in addition to the fact that the structure will not require cleaning after use and may be employed by technicians who need not be as highly skilled and trained as has heretofore been required where conventional pipettes and assemblies have been used.
  • FIG. 1 is a perspective view of a pipette assembly
  • FIG. 2 is a partly sectional and fragmentary view of the assembly as shown in FIG. 1;
  • FIG. 3 is a fragmentary sectionalview showing an alternative structure which may be employed
  • FIGS. 4 to 9 inclusive are somewhat schematic and partly sectional views illustrative of the steps followed in utilizing one form of pipette assembly embracing the present teachings;
  • FIG. 10 is a fragmentary sectional side view of an alternative form of assembly and showing the same with the parts in one position; a
  • FIG. 11 is a similar view, but showing the parts in a different position
  • FIG. 12 is a partly sectional and fragmentary view illustrative of a further form of assembly.
  • FIG. 13 is a similar view of still another form. of such assembly.
  • the numeral 15 indicates the capillary tube, the inner end of which is mounted by a sleeve 16, in turn connected to a reservoir and actuating unit 17.
  • Tube 15 provides the pipette proper. While it may be produced by employing a proper plastic material of the resin type, it is preferred that it be manufactured of glass.
  • Sleeve 16 may be formed of a resin, although other materials could be employed.
  • Reservoir 17 should be compressible to vary its internal volume. It should be formed of a plastic such as trifluorchloroethylene or vinydene chloride co-poly'mer, both of which will hold diluent for long periods of time without loss. Also, both may be used in sufficiently thin gauge so that the reservoir body will embrace flexible and resilient characteristics.
  • the forward end of sleeve 16 preferably defines a tip States ate-t fiidgd Patented .iuly 24-, 1&62
  • a sheath 20, as indicated in dotted lines in FIG.- 1, may enclose tube 15 to protect the latter and bear against the surface of tip portion 18, from which it may readily be separated when the assembly is to be used.
  • sleeve 16 terminates in a reduced flange 21 which is received within the boreof collar 22 formed at the forward end of reservoir 17.
  • a manipulating member or part is conveniently mounted by sleeve 16 and may take the form of an integral tab 23 to which a label 23 may be suitably attached.
  • This label presents a surface to receive proper indicia, which may include, for example, the date, specimen number, the patients name, etc.
  • a volume of diluent 2d of a type corresponding to the count to be performed and proportioned to the volume of pipette tube 15 is disposed within reservoir 17. Also extending into the reservoir interior is the head portion 25 of a mixing bead provided with a plug or stem 26.
  • That stern has a diameter such that it extends into the bore of sleeve 16 to seal the latter.
  • the area of head 25 is preferably greater than the bore defined by collar 22. Therefore, with the parts in the positions shown in FIGS. 1 and 2, the diluent body 24 within the reservoir will not pass into the bore of sleeve 16 or other parts of the assembly. Should the sleeve be detached from the reservoir 17, then the bead will be retained by the latter and will drop into its interior upon the reservoir being shifted to an upright position.
  • the numeral 27 indicates the wall of such a glass reservoir.
  • body 27 In common with reservoir 17, it will contain a body of diluent 28.
  • body 27 In order to provide for conditions of pressure above and below atmospheric, body 27 may at its rear end define a neck 28.
  • a bulb 29 To the latter there is applied a bulb 29 conveniently formed of rubber. It is apparent that by compressing this bulb and then allowing it to expand, an effect is accomplished corresponding to that achieved by compressing reservoir 17 and then allowing it to expand. If a construction such as is illustrated in FIG.
  • the forward end of the reservoir 27 may have attached to it a sleeve such as 16, formed of plastic or other elected material, and in turn carrying a label or tag 23 of, for example, paper, and mounting a capillary pipette tube, preferably of glass.
  • Such a tube will have a bore surface which is completely clean.
  • the thin wall of the pipette is provided by drawing a clean tube of larger bore in a flame.
  • the tube is cut by cleavage, after the tube surface has been scratched with a diamond or Carborundum wheel.
  • the outside diameter of tube 15 should be less than the area of a drop of blood into which its outer end is to be dipped or with which that end is to be placed in contact. Therefore, the tube may involve an outside diameter of .036" with a plus or minus factor on the order of .001".
  • the bore diameter should preferably be on the order of .0285" with a plus or minus factor of .0004. 1
  • diluent solutions contemplated would in the case of'red cells, preferably involve:
  • the capillary tube embodies glass, it has been found that it is so light that even if dropped on a relatively hard surface, it will not shatter. Whether it be made of glass or of a suitable plastic, ordinarily its outside diameter should not substantially exceed 1 mm. Where the volumes of the capillary tubes are different for red and white cell counts, then, of course, the same size reservoirs may be used in the different assemblies. Likewise, the same volume of diluent may be contained in each reservoir.
  • the blood will rise in the capillary tube to completely fill the bore of the latter.
  • the rate of penetration, penetrating power or penerating pressure of liquids such as blood into capillary tubes is dependent on the surface tensiond and the advancing contact angle of the liquid. Any increase in the contact angle is to be avoided.
  • a sharp edge is present which reduces or eliminates the contact angle, with resultant increased adhesion tension or wetting power.
  • This edge being formed by cleavage of the tube, has a crystalline structure that is different from the outer and inner wall surfaces of that tube.
  • This edge surface approaches being the cleanest and most perfect surface attainable by cleavage of a single crystal.
  • the contact angle of a liquid such as water with this surface is as close to zero as can be.
  • the physician or technician will, for example, lance the tip of the patients finger, so that (FIG. 4) a drop 30 of blood appears on the surface of that finger.
  • Reservoir 17 will be held in at least an upwardly inclined position and sleeve 16 detached therefrom. In such detachment the bead will, of course, drop into the interior of the reservoir.
  • the sleeve, together with the pipette tube 15 mounted thereby, may now be grasped, or if a tab 23 be associated therewith, the latter may be gripped to furnish a manipulating unit.
  • tube 15 by maintaining tube 15 at an angle slightly inclined upwardly from the horizontal, its outer end may be brought into contact with the surface of drop 30.
  • the contact angl of the blood with the bore surface 31 of the tube 15 will approach zero.
  • the end area of the tube will be less than the area of the blood drop.
  • the blood therefore rises in the tube to fill the latter completely by capillary attraction, because the adhesive force between the glass surface of this bore and the blood is greater than the cohesive force of the blood molecules themselves.
  • the column of blood will extend throughout the entire length of the bore 3-1 and terminate at its upper or inner end in line with the edge of tube 15. This column will remain intact under all circumstances, so that it is unnecessary to resort to procedures as heretofore practiced to prevent a portion of the column being accidental-1y displaced from the bore.
  • the outer end of the capillary tube may be introduced into the reservoir 17.
  • the walls of the reservoir will be partially compressed, as also illustrated in FIG. 5.
  • the pressure upon the side walls is released, as illustrated in FIG. 6. Accordingly, an aspirating action occurs which serves to draw the entire liquid column within tube 15 into the body of diluent within the reservoir.
  • the reservoir may now again be compressed, as in FIG. 7. This will force diluent up through the bore of the tube and into the sleeve 16. With the release of this compressive action, the displaced liquid is again drawn into the reservoir.
  • the sleeve is unseated from the reservoir and reversed, so that tube 15 extends outwardly.
  • the reservoir is shaken, so that the mixing bead will be agitated within the solution contained in the reservoir. This will assure an even dispersion of blood throughout the body of the solution.
  • a desired volume of the solution may be discharged, for example, upon a counting chamber 32, to which a glass 33 had been applied in accordance with conventional techniques.
  • the pipette tube 15 collects and measures blood accurately in a single automatic operation, which is instantly initiated simply by touching the tip of the capillary to the drop of blood.
  • the assembly collects and measures the blood, since the latter is drawn into the tube bore by capillary action and is measured by the length of the tube. Accordingly, unerring physical forces and factors are substituted for the human judgment, skill and experience required to carry out the same operation with conventional equipment.
  • the blood and diluent are not drawn into the tube by mouth. The required volumes are definitely achieved, rather than by relying on the technician attempting to line up the meniscus at the top of a liquid column with a mark on the outside of the tube.
  • the numeral 34 indicates a reservoir corresponding to reservoir 17 and containing a predetermined volume of diluent 35.
  • a mixing bead 36 of suitable configuration is disposed within this reservoir.
  • the forward end of the reservoir is defined by a wall through which a passage 37 extends. That passage is initially closed by a stopper portion 38 formed in the base portion of an adaptor and mounting member involvinga cylindrical body 39 preferably formed with an outstanding fiange 4th at the end opposite reservoir 34.
  • This adaptor serves to mount the base portion of a lancet 4 1, the point of which extends beyond the adaptor. Also, it serves to support a sleeve 42 corresponding to sleeve 16 and also supporting the inner end of a capillary tube 43 corresponding to tube 15.
  • the physician or technician is provided in the assembly of FIG. 12 with an instrument such that the drop of blood may be created without resorting to an element foreign to the assembly.
  • the user will simply dismount the adaptor 39 from the reservoir 3%, while maintaining the latter in an upright position so that diluent does not flow outwardly through the bore 37.
  • the adaptor itself may serve as a manipulating element for projecting and retracting the sterile lancer point with respect to the surface tobe pierced.
  • the adaptor may now be discarded. Thereupon, the technique as afore traversed maybe followed in detail in order to provide the diluted solution for blood count purposes.
  • FIG. 13 in which the numeral 44 indicates the reservoir, which corresponds to reservoir 17 and contains a body of diluent 45. Also, this reservoir preferably contains a mixing bead or element 47.
  • the forward end wall 48 of the reservoir maintains the interior of the same isolated.
  • the outer face of end wall 48 is provided with a recess the base of which defines a. diaphragm portion 459.
  • This recess has a diameter such that the rear end of a sleeve 50, corresponding to sleeve 16, will be accommmodate-d' and retained therein by frictional contact of the surfaces.
  • the sleeve in turn supports a capillary tube 51 corresponding to tube 15.
  • the numeral 52 indicates a reservoir preferably formed of plastic material so as to be compressible.
  • the body of the reservoir is closed at one end by a wall 53 having a bore or opening, while at the other end it is closed by a wall provided with an opening which may be defined by a tubular tip 54.
  • the reservoir contains a body of diluent 55 related to the volume of blood or other liquid provided by the bore of the capillary tube forming a part of the assembly.
  • a mixing bead 56 may be disposed within the reservoir 52.
  • An actuator preferably in the form of a tube of plastic material, as indicated at 57, extends through the opening in wall 53. At its inner end it serves to mount the adjacent end of a capillary tube 58 corresponding to the tube 15.
  • Tube 58 may be housed by a sheath (not shown). Likewise, tube 57 may be suitably protected or sealed.
  • the finger of the patient will be lanced, and the outer end of capillary tube 58 will be brought into engagement with the resulting drop of blood by inclining tube 58 in an upward direction, as illustrated in FIG. 4A. Under these circumstances the bore of tube 58 will automatically draw a volume of blood upwardly by capillary action until the bore of that tube is filled.
  • a predetermined volume of blood is collected which is the desired quantity when related to the volume of diluent 55.
  • the column of blood will not pass beyond the inner end of tube 58.
  • tube 57 as a manipulating element, tube 58 is retracted to a point where it is wholly contained within reservoir 52, as shown in FIG. 11.
  • head 56 assures an even dispersion of the blood throughout the solution.
  • a pressure on its walls will. serve to dispense desired amounts of solution onto a receiving surface such as a counting chamber.
  • the entire apparatus may be discarded after a single use. No cleaning of the parts will therefore be necessary after a final amount of solution has been dispensed. While the present apparatus is intended primarily for use in connection with blood counts, it is apparent that it will also: be useful in connection with analytical Work involving liquids other than blood.
  • a pipette assembly including in combination a flexible reservoir containing a predetermined amount of diluent and having one open end, a capillary tube having a blood-receiving bore capacity precisely related to the amount of diluent, means for detachably connecting one end of said tube with the open reservoir end, said connecting means including a sleeve having one end permanently connected to said tube, said sleeve having a bore of greater diameter than the tube bore and in communication with the latter, the sleeve adjacent its opposite end providing a surface to seaiingly and detachably engage with a surface of said reservoir, and means for initially sealing the bore of said sleeve against a flow of liquid from the reservoir into said sleeve.
  • said sealing means comprising an agitating element having a body disposed within said reservoir and of a size larger than the open end thereof and a stem extending through such end and in detachable engagement with the bore surface of said sleeve.
  • a pipette assembly including in combination a capillary tube having an outer end, such end being contaotable with epidermis supporting a drop of blood to immerse that end in the blood, the inner tube end being open to the atmosphere, whereby blood will flow solely by capillary action through the tube to entirely fill the bore of the latter and be maintained by capillary attraction therein as said tube is subsequently removed from a position adjacent the epidermis, a separate reservoir containing a volume of diluent precisely related to the capacity of the tube bore, said reservoir having an opening, the outer end of said tube being insertable through said opening to extend into the interior of said reservoir for the discharge of blood theretofore retained within the tube bore, and means providing a mounting and seal between the edges of said opening and tube to detachably retain the latter in such position.
  • At least a part of said reservoir being flexible and resilient to diminish the interior capacity thereof when subjected to compression and to increase such capacity when returning to a normal position, such return resulting in said air flow.
  • said mounting and seal comprising a sleeve having a bore larger than the diameter of said tube and secured to said tube adjacent its inner end.
  • a tube-manipulating part extending outwardly from said sleeve and furnishing indicia-receiving surfaces.
  • a plug initially obstructing communication between the outer atmosphere and the interior of said reservoir and said plug being displaceable into the reservoir interior to provide a mixing bead therein.
  • said sleeve providing a liquid-receiving part in communication with the tube bore and extending outwardly of said reservoir with said tube inserted in the latter and the resilient part of said reservoir being thereupon compressible to force liquid outwardly through the tube bore into said receiving part.
  • a reservoir to receive diluent and formed with an opening the edge zones of which define surfaces for engagement with sunfaces ancillary to said tube to mount the latter, a plug obstructing said opening and said plug being displaceable into the reservoir interior to provide a mixing head for the liquid therein.
  • a head portion forming a part of said plug, said portion having an area greater than that of said opening and lying within the reservoir interior whereby said plug may not be separated from said reservoir.

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US721139A 1958-03-13 1958-03-13 Method of providing for blood count and pipette and assembly for use therein Expired - Lifetime US3045494A (en)

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NL135023D NL135023C (ja) 1958-03-13
NL275145D NL275145A (ja) 1958-03-13
US721139A US3045494A (en) 1958-03-13 1958-03-13 Method of providing for blood count and pipette and assembly for use therein
GB6103/62A GB962356A (en) 1958-03-13 1962-02-16 Pipette assembly
DEG34306A DE1297361B (de) 1958-03-13 1962-02-21 Vorrichtung zur Blutuntersuchung durch Auszaehlen der Blutkoerperchen
CH225462A CH384899A (fr) 1958-03-13 1962-02-23 Procédé pour l'obtention d'une solution d'un liquide à analyser et dispositif pour sa mise en oeuvre
FR889052A FR1317488A (fr) 1958-03-13 1962-02-23 Procédé de numération globulaire du sang et pipette et dispositif pour sa mise enoeuvre

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US721139A US3045494A (en) 1958-03-13 1958-03-13 Method of providing for blood count and pipette and assembly for use therein
GB6103/62A GB962356A (en) 1958-03-13 1962-02-16 Pipette assembly
DEG34306A DE1297361B (de) 1958-03-13 1962-02-21 Vorrichtung zur Blutuntersuchung durch Auszaehlen der Blutkoerperchen
CH225462A CH384899A (fr) 1958-03-13 1962-02-23 Procédé pour l'obtention d'une solution d'un liquide à analyser et dispositif pour sa mise en oeuvre
FR889052A FR1317488A (fr) 1958-03-13 1962-02-23 Procédé de numération globulaire du sang et pipette et dispositif pour sa mise enoeuvre

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US3172293A (en) * 1961-06-14 1965-03-09 Beckman Instruments Inc Dispensing pipette
US3322114A (en) * 1964-07-01 1967-05-30 Hynson Westcott & Dunning Inc Apparatus for securing a sample of blood plasma for testing
US3603156A (en) * 1970-02-04 1971-09-07 Gradko Glass Lab Inc Disposable dilution system
US3640388A (en) * 1970-08-20 1972-02-08 Damon Corp Dialyzing liquid-collecting container
US3640267A (en) * 1969-12-15 1972-02-08 Damon Corp Clinical sample container
US3646817A (en) * 1968-10-25 1972-03-07 Bio Dynamics Inc Pipette
US3741732A (en) * 1972-05-18 1973-06-26 Becon Dickinson And Co Fractional-fill pipette assembly
US3779083A (en) * 1971-05-28 1973-12-18 Becton Dickinson Co Method and apparatus for measuring precise micro quantities of fluid samples
US3901085A (en) * 1972-11-30 1975-08-26 Jean Marie Faure Pipette or similar apparatus for measuring determined volumes of liquid
US3905768A (en) * 1972-08-29 1975-09-16 Hach Chemical Co Disposable weight burette and method for carrying out titrimetric analyses
US3951313A (en) * 1974-06-05 1976-04-20 Becton, Dickinson And Company Reservoir with prepacked diluent
US3952599A (en) * 1972-05-18 1976-04-27 Ayres Waldemar A Fractional-fill capillary pipette and method
EP0001741A1 (de) * 1977-10-07 1979-05-16 Walter Sarstedt Kunststoff-Spritzgusswerk Mittel zur Erleichterung der Auszählung von Thrombozyten in Blutproben
WO1979001131A1 (en) * 1978-05-26 1979-12-27 R Turner Liquid sample collector device
FR2483213A1 (fr) * 1980-05-30 1981-12-04 Mallinckrodt Inc Trousse de diagnostic et son utilisation dans un procede de diagnostic
US4378333A (en) * 1980-12-11 1983-03-29 Laipply Thomas C Device for preparing blood smears on glass slides and method therefor
US4463616A (en) * 1982-03-24 1984-08-07 Instrumentation Laboratory Inc. Sample handling apparatus
EP0235691A2 (de) * 1986-02-26 1987-09-09 Hoechst Aktiengesellschaft Vorrichtung zur Applikation von Arzneimittelsuspensionen
US5059398A (en) * 1985-07-22 1991-10-22 Drummond Scientific Company Disposable preselected-volume capillary pipet device
US5627037A (en) * 1990-08-07 1997-05-06 Becton Dickinson And Company One step method for detection and enumeration of absolute counts of one more cell populations in a sample
FR2774765A1 (fr) * 1998-02-06 1999-08-13 Boule Medical Ab Procede pour effectuer une etape de dilution dans un appareil d'analyse du sang et cet appareil
WO2001013795A1 (en) * 1999-08-23 2001-03-01 European Institute Of Science Disposable test vial with sample delivery device
US6457612B1 (en) * 2001-10-12 2002-10-01 Amphastar Pharmaceuticals Inc. Sealable and manipulable pre-filled disposable pipette
US6685678B2 (en) * 2000-03-22 2004-02-03 Docusys, Inc. Drug delivery and monitoring system
US20050064582A1 (en) * 1990-06-04 2005-03-24 University Of Utah Research Foundation Container for carrying out and monitoring biological processes
US20060009741A1 (en) * 2004-07-08 2006-01-12 Jenn-Hae Luo Sealed medicine dropper containing a liquid
US7081226B1 (en) 1996-06-04 2006-07-25 University Of Utah Research Foundation System and method for fluorescence monitoring
EP1743171A2 (en) * 2004-03-05 2007-01-17 Metrika, Inc. Mechanical device for mixing a fluid sample with a treatment solution
EP1752755A1 (de) * 2005-08-10 2007-02-14 Roche Diagnostics GmbH Probenaufnahme- und-dosiervorrichtung mit integrierten Flüssigkeitskompartimenten
US20090159714A1 (en) * 2007-12-21 2009-06-25 Coyne Iii Martin M Medication Administration Tracking
USD602166S1 (en) 2007-12-21 2009-10-13 Becton, Dickinson And Company Medication chart with labels
USD602167S1 (en) 2007-12-21 2009-10-13 Becton, Dickinson And Company Medication chart with labels
JP2011502623A (ja) * 2007-11-12 2011-01-27 ボドイテクフメド インコーポレイテッド 経皮体液サンプリング及び前処理装置及び方法
US20110132279A1 (en) * 2008-03-06 2011-06-09 Joseph Le Mer Equipment for producing domestic hot water
EP2932992A4 (en) * 2012-12-17 2016-08-17 Terumo Corp SYRINGE WITH HANGING LABEL
US9694358B2 (en) 2008-03-28 2017-07-04 Orion Diagnostica Oy Sampling and dispensing device
US20180036725A1 (en) * 2016-08-08 2018-02-08 Nalge Nunc International Corporation Capillary transfer pipettes and related methods
WO2023030577A1 (de) * 2021-08-31 2023-03-09 Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung Halter für ein einzelnes kapillarröhrchen und sammelvorrichtung für mehrere halter

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US4477414A (en) * 1981-05-20 1984-10-16 Fumakilla Limited Evaporative container
FR2563990B1 (fr) * 1984-05-10 1988-08-26 Labarthe Jean Instrument de microprelevement du sang
DE9203973U1 (de) * 1992-03-25 1993-02-11 Gundelsheimer, Peter H., 6760 Rockenhausen Laborröhrchen für die Dosierung von Flüssigkeiten
WO2001052989A2 (en) * 2000-01-18 2001-07-26 Smith Michael P Method for environmental sampling

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Cited By (60)

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Publication number Priority date Publication date Assignee Title
US3172293A (en) * 1961-06-14 1965-03-09 Beckman Instruments Inc Dispensing pipette
US3322114A (en) * 1964-07-01 1967-05-30 Hynson Westcott & Dunning Inc Apparatus for securing a sample of blood plasma for testing
US3646817A (en) * 1968-10-25 1972-03-07 Bio Dynamics Inc Pipette
US3640267A (en) * 1969-12-15 1972-02-08 Damon Corp Clinical sample container
US3603156A (en) * 1970-02-04 1971-09-07 Gradko Glass Lab Inc Disposable dilution system
US3640388A (en) * 1970-08-20 1972-02-08 Damon Corp Dialyzing liquid-collecting container
US3640393A (en) * 1970-08-20 1972-02-08 Damon Corp Liquid container having pressure-protected dialyzing membrane
US3779083A (en) * 1971-05-28 1973-12-18 Becton Dickinson Co Method and apparatus for measuring precise micro quantities of fluid samples
US3741732A (en) * 1972-05-18 1973-06-26 Becon Dickinson And Co Fractional-fill pipette assembly
US3952599A (en) * 1972-05-18 1976-04-27 Ayres Waldemar A Fractional-fill capillary pipette and method
US3905768A (en) * 1972-08-29 1975-09-16 Hach Chemical Co Disposable weight burette and method for carrying out titrimetric analyses
US3901085A (en) * 1972-11-30 1975-08-26 Jean Marie Faure Pipette or similar apparatus for measuring determined volumes of liquid
US3951313A (en) * 1974-06-05 1976-04-20 Becton, Dickinson And Company Reservoir with prepacked diluent
EP0001741A1 (de) * 1977-10-07 1979-05-16 Walter Sarstedt Kunststoff-Spritzgusswerk Mittel zur Erleichterung der Auszählung von Thrombozyten in Blutproben
WO1979001131A1 (en) * 1978-05-26 1979-12-27 R Turner Liquid sample collector device
FR2483213A1 (fr) * 1980-05-30 1981-12-04 Mallinckrodt Inc Trousse de diagnostic et son utilisation dans un procede de diagnostic
US4376634A (en) * 1980-05-30 1983-03-15 Mallinckrodt, Inc. Assay kit having syringe, dilution device and reagents within sealed container
US4378333A (en) * 1980-12-11 1983-03-29 Laipply Thomas C Device for preparing blood smears on glass slides and method therefor
US4463616A (en) * 1982-03-24 1984-08-07 Instrumentation Laboratory Inc. Sample handling apparatus
US5059398A (en) * 1985-07-22 1991-10-22 Drummond Scientific Company Disposable preselected-volume capillary pipet device
EP0235691A3 (en) * 1986-02-26 1988-08-17 Hoechst Aktiengesellschaft Device for dispensing medicinal suspensions
AU598519B2 (en) * 1986-02-26 1990-06-28 Hoechst Aktiengesellschaft Device for the administration of medicament suspensions
EP0398397A1 (de) * 1986-02-26 1990-11-22 Hoechst Aktiengesellschaft Verwendung der Vorrichtung zur Applikation von Arzneimittelsuspensionen und Verfahren zur Herstellung einer homogenen Mischung dieser Suspension
DE8717881U1 (de) * 1986-02-26 1991-01-03 Hoechst Ag, 65929 Frankfurt Vorrichtung zur Applikation von Arzneimittelsuspensionen
EP0235691A2 (de) * 1986-02-26 1987-09-09 Hoechst Aktiengesellschaft Vorrichtung zur Applikation von Arzneimittelsuspensionen
US20050064582A1 (en) * 1990-06-04 2005-03-24 University Of Utah Research Foundation Container for carrying out and monitoring biological processes
US7273749B1 (en) * 1990-06-04 2007-09-25 University Of Utah Research Foundation Container for carrying out and monitoring biological processes
US7745205B2 (en) 1990-06-04 2010-06-29 University Of Utah Research Foundation Container for carrying out and monitoring biological processes
US5627037A (en) * 1990-08-07 1997-05-06 Becton Dickinson And Company One step method for detection and enumeration of absolute counts of one more cell populations in a sample
US7081226B1 (en) 1996-06-04 2006-07-25 University Of Utah Research Foundation System and method for fluorescence monitoring
FR2774765A1 (fr) * 1998-02-06 1999-08-13 Boule Medical Ab Procede pour effectuer une etape de dilution dans un appareil d'analyse du sang et cet appareil
WO2001013795A1 (en) * 1999-08-23 2001-03-01 European Institute Of Science Disposable test vial with sample delivery device
US6319209B1 (en) 1999-08-23 2001-11-20 European Institute Of Science Disposable test vial with sample delivery device for dispensing sample into a reagent
US20040082918A1 (en) * 2000-03-22 2004-04-29 Docusys, Inc. Drug delivery and monitoring system
US6685678B2 (en) * 2000-03-22 2004-02-03 Docusys, Inc. Drug delivery and monitoring system
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Also Published As

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NL275145A (ja) 1962-02-22
NL135023C (ja)
DE1297361B (de) 1969-06-12
GB962356A (en) 1964-07-01
FR1317488A (fr) 1963-02-08
CH384899A (fr) 1965-02-26

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