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US20060154202A1 - Arrangement of two or more implants provided with growth-stimulating substance(s) - Google Patents

Arrangement of two or more implants provided with growth-stimulating substance(s) Download PDF

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Publication number
US20060154202A1
US20060154202A1 US10/521,113 US52111305A US2006154202A1 US 20060154202 A1 US20060154202 A1 US 20060154202A1 US 52111305 A US52111305 A US 52111305A US 2006154202 A1 US2006154202 A1 US 2006154202A1
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US
United States
Prior art keywords
implants
jaw bone
arrangement
bone
implant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/521,113
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English (en)
Inventor
Jan Hall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nobel Biocare Services AG
Koninklijke Philips NV
Original Assignee
Nobel Biocare AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nobel Biocare AB filed Critical Nobel Biocare AB
Assigned to NOBEL BIOCARE AB (PUBL.) reassignment NOBEL BIOCARE AB (PUBL.) ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HALL, JAN
Assigned to KONINKLIJKE PHILIPS ELECTRONICS N.V. reassignment KONINKLIJKE PHILIPS ELECTRONICS N.V. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HAITSMA, JAAP ANDRE, KALKER, ANTONIUS ADRIANUS CORNELIS MARIA, LINNARTZ, JOHAN PAUL MARIE GERARD, STARING, ANTONIUS ADRIAAN MARIA, WIRTZ, GIJSBRECHT CAREL
Publication of US20060154202A1 publication Critical patent/US20060154202A1/en
Priority to US12/126,542 priority Critical patent/US8113834B2/en
Assigned to NOBEL BIOCARE SERVICES AG reassignment NOBEL BIOCARE SERVICES AG ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: NOBEL BIOCARE AB
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0003—Not used, see subgroups
    • A61C8/0004—Consolidating natural teeth
    • A61C8/0006—Periodontal tissue or bone regeneration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2/2846—Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2/2803—Bones for mandibular reconstruction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Definitions

  • the present invention relates to an arrangement of two or more implants arranged in succession in the jaw bone and bearing or comprising growth-stimulating substance(s), here called GSS, which, as a function of secretion of body fluid at the implants, is/are intended to be released and form new bone around the implants.
  • GSS growth-stimulating substance(s)
  • GSS be applied to implants so that, when the implants are in their positions fitted in the jaw bone holes, the GSS is released and builds up a new bone structure which is intended to increase the stability of the implant and/or optimize the appearance around the implant.
  • GSS matrix molecules, growth factors and differentiation factors and/or peptides with growth-stimulating properties.
  • the implants should be placed in the jaw bone at sites where the condition of the jaw bone in the initial stage is best or acceptable.
  • this has meant that the implant has been given a location which is not advantageous for the dental construction to be applied to the implant and which has a negative impact on the construction in question. In the worst cases, this can mean that the patient has to do without the desired dental construction.
  • a degenerated jaw bone can be provided with implants used for supporting the dental construction. The present invention aims to solve these problems among others.
  • problems may arise in obtaining the correct spatial distribution of newly formed bone in the jaw bone.
  • the jaw bone's soft tissue with or without periosteum and/or a possible strengthening element, for example a polymer membrane, will protect the implant or implants during the formation of new bone.
  • problems may arise in correctly using the soft tissue and possible periosteum and/or strengthening element.
  • the invention aims to solve these problems too.
  • the feature which can principally be regarded as characterizing the invention is that the implants are designed to work with a release process for the growth-stimulating substance or substances GSS, permitting a leveling-out effect along the extent of the jaw bone in the horizontal and/or vertical direction and/or a level-raising effect in the vertical direction.
  • the latter is intended to be able to function for jaw bones which have one or more recesses in the horizontal plane.
  • One or more first implants can in this case be arranged at one or more recesses.
  • the release function can preferably be arranged so that it is greater on or at the implant or implants fitted at the recess or recesses compared to the implant or implants arranged at a higher portion or higher portions of the jaw bone.
  • the release function is to be arranged to cause or bring about a level increase along the whole jaw bone.
  • the implant is covered with the jaw bone's soft tissue so that inner spaces are formed at each implant and at parts of the jaw bone and its soft tissue.
  • a strengthening element can in this case be used in conjunction with the jaw bone and soft tissue, possibly with periosteum, so that no collapse takes place in the initial stage and the stage of incorporation.
  • the strengthening elements (for example polymer membranes or membranes made of metal (titanium)) can be of a temporary or permanent nature and can in some cases be secured to the jaw bone by means of securing members, for example screws, etc.
  • the strengthening element or strengthening elements can be provided with projecting parts via which each strengthening element can be anchored in the jaw bone, by means of screws for example.
  • the invention it is possible, in connection with the fitting of implants, to obtain high-quality new bone formations so that they permit a compensating effect, for example both in the horizontal plane of the jaw bone and in the vertical plane/vertical planes (on the outsides and/or insides of the jaw bone).
  • the work can be carried out with essentially known means and techniques.
  • GSS can be applied to implants with threads and/or outsides which have been provided with porous oxide layers with pores for storing GSS.
  • the GSS forming the new bone structure can, if so desired, be combined with autologous bone, allogenic bone, xenografts and/or synthetic substances or materials available on the general market.
  • FIG. 1 shows, in horizontal section, a lower jaw bone in which implants have been fitted and new bone formations have been initiated so that compensating effects in the horizontal plane of the jaw bone, i.e. the plane coinciding with the plane of the figure in FIG. 1 , have been created, and where a strengthening element has been shown in connection with the implants and the jaw bone,
  • FIG. 2 shows, in vertical section, implants arranged in or at irregularities in the jaw bone, one of the implants having been provided with a strengthening element, and the newly formed bone portions have created a level-compensating effect in the vertical direction or horizontal direction of the jaw bone, and
  • FIG. 3 shows, in a diagrammatic side view, the new bone formation function having the effect of raising the level of the lower jaw.
  • a lower jaw bone is shown diagrammatically by 1 .
  • the lower jaw bone has defects or irregularities 2 , 3 , 4 , 5 , 6 along its side surfaces 1 a, 1 b extending substantially at right angles to the plane of the figure in FIG. 1 or inclined slightly from the bottom upward where they merge into the top surface 1 c of the jaw bone 1 .
  • the main center line of the jaw bone is shown by 7 .
  • a first implant 8 has a vertical axis 8 a which coincides with the arc-shaped line 7 .
  • a second implant 9 is arranged in the jaw bone such that its longitudinal axis extends substantially vertically through the center line 7 .
  • the implant 10 also has its vertical axis 10 a arranged in said arc-shaped line 7 .
  • the implants can be arranged substantially vertically in the jaw bone or can slope slightly in the latter.
  • the implants are arranged in formed/drilled jaw bone holes, the jaw bone holes for implants 9 and 10 being shown diagrammatically with reference numbers 1 d and 1 e.
  • the optimum implant positioning in the jaw bone shown in FIG. 1 means that the implant 8 a lies near the defect or irregularity 3 .
  • the implant 9 is arranged at the defects or irregularities 4 and 5 .
  • the implant is arranged at the defects or irregularities 2 and 6 .
  • new bone formations 11 , 12 , 13 , 14 and 15 will be created so that the implants 8 , 9 and 10 acquire the necessary or accepted embedding in newly formed bone and stability.
  • spaces 17 , 18 , 19 , 20 and 21 will be formed so that body fluids containing cells, for example stem cells, penetrate into each space from the jaw bone and possibly from its periosteum 21 .
  • said periosteum and the soft tissue of the jaw bone can stretch across the defects/irregularities to form the spaces 17 , 18 , 19 , 20 and 21 .
  • strengthening elements for example membranes 22 .
  • Said strengthening elements can be stiff and can be shaped or folded over the defects. Alternatively, they can be anchored to the side surface of the jaw bone by means of securing members/screws 23 , 24 .
  • the strengthening element may possibly be provided with GSS 22 a on the inner surface 22 b.
  • the implants 9 and 10 have a degree of exposure to the spaces 19 and 21 , which degree of exposure is shown by the angle ⁇ , which can have values of up to 180° for example.
  • Each implant is provided with one or more concentrations of GSS, which concentration or concentrations has/have been shown by 25 in exaggerated thickness for reasons of clarity.
  • the other implants too are provided with said concentrations or layers of GSS, and the concentration or layer on the implant 10 is indicated by 26 .
  • body fluids can be secreted in accordance with the above and can penetrate into said spaces where at the same time GSS is released and interacts with the cells in the body fluids, and the formation of bone is thus effected in a manner known per se.
  • the implant 8 has been provided with a strengthening element which extends over the top surface of the implant.
  • the strengthening element is indicated by 27 and in this case has projecting anchoring members 27 a which extend radially outward, for example, from the center part of the strengthening element.
  • the strengthening element can have two or more projecting portions and, in the illustrative embodiment shown in FIG. 1 , it has four portions. At each projecting portion, the strengthening element can be screwed into the jaw bone with anchoring members/screws, for example screws 28 , 29 , the screw 28 having been screwed into the jaw bone in the direction toward its horizontal plane, and the screw 29 having been screwed in the direction toward a vertical plane of the jaw bone.
  • the screw 29 is applied on the outer surface of the jaw bone.
  • a tightening screw 30 for one portion is secured on the vertical inner surface of the jaw bone.
  • the implants can be made of titanium, ceramic, etc.
  • the strengthening elements can be made of durable material, for example polymer membrane, titanium, stainless steel, etc.
  • the strengthening elements can be secured in a releasable or permanent manner.
  • the implants can be threaded and can be of the self-tapping type. Alternatively, thread taps can be used to form the jaw bone holes 1 d, 1 e, into which the implants 8 , 9 and 10 are thereafter screwed.
  • defects or irregularities 31 , 32 and 33 may also be present in the vertical plane, i.e. coinciding with the plane of the paper in FIG. 2 .
  • implants 34 , 35 may be able to be placed at the recesses 31 and 32 .
  • the implants 36 , 37 are fitted at elevated parts 38 , 39 along the jaw bone.
  • the implants 36 and 37 therefore have a greater degree of recessing in the jaw bone than do the implants 34 and 35 .
  • the implant has first portions 36 a which are recessed in the jaw bone, and second portions 36 b which are exposed from the jaw bone.
  • the first portions can have a height H′ which is, for example, 50-80% of the total height H of the implant.
  • the height H′′ of the exposed portion 36 b has a degree of exposure corresponding to said degree of recessing.
  • the implant 34 has a first portion which has a height h′ which is relatively small in relation to the total height h of the implant.
  • the exposed part 346 has a height, h′′ which can be of prominent size.
  • the first portion h′ can have values of between 10 and 20% of the total height h.
  • the new bone formation 40 , 41 will be arranged so that the function of new bone formation affords a leveling in the horizontal plane of the jaw bone, cf. the top surfaces 42 and 43 which adjoin the upper surfaces 44 and 45 of the top surface of the jaw bone structure.
  • the soft tissue 47 can be used to create a space for the formation of new bone.
  • a strengthening element 46 can be included or replace the soft tissue and periosteum function at the new bone formation 40 , 41 .
  • the strengthening element is in this case provided with a top part 46 a and with arm-shaped members 46 b which extend away from said top part 46 a.
  • the implants 34 , 35 , 36 and 37 can be provided with different amounts of GSS or preferably different concentrations along the circumference and/or height. The principle is in this case such that the parts of the implant exposed in the initial stage bear a greater amount or greater concentration of GSS than those parts which extend within the jaw bone/the jaw bone hole.
  • said strengthening or fixing element 46 can be used to stabilize the implant during the stage of incorporation.
  • the design of the strengthening element is dependent on the jaw bone structure, on the shape of the implant and on its extent within the jaw bone.
  • FIG. 3 shows an arrangement where a completely resorbed jaw bone 48 is to be provided with implants 49 , 50 , 51 and 52 .
  • the implants are initially anchored in the remaining jaw bone via their first portions (cf. above).
  • the upwardly directed second portions can be covered with soft tissue, possibly with periosteum 53 and/or a strengthening element 54 which can serve as a stabilizing element for the implants during incorporation.
  • closed spaces 53 , 54 , 55 , 56 and 57 are obtained.
  • body fluid can be secreted from the jaw bone, and from the possibly used soft tissue and periosteum, and can penetrate into said spaces.
  • the implants 47 , 50 , 51 and 52 are charged or provided with GSS which, when released from the implants, takes part in the interaction with the body fluids in order to form new bone.
  • new bone 58 , 59 , 60 and 61 has formed in the spaces.
  • the new bone formation preferably results in the level being raised along the entire extent of the jaw bone.
  • the implants are fixed via the new bone formation and, after incorporation, acquire stable positions in the jaw bone. In some cases it may be desirable to complete the space between the implant and the bone/soft tissue with bone substitute, for example autologous bone, allogenic bone, xenografts and/or synthetic substances.
  • the invention is not limited to the embodiment shown above by way of example, and instead it can be modified within the scope of the attached patent claims and the inventive concept.
  • the implants are used as supports for dental constructions, for example a bridge which has been symbolized by 62 in FIG. 2 .

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)
US10/521,113 2002-07-25 2003-06-26 Arrangement of two or more implants provided with growth-stimulating substance(s) Abandoned US20060154202A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/126,542 US8113834B2 (en) 2002-07-25 2008-05-23 Arrangement of two or more implants provided with growth-stimulating substance(s)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0202318A SE522984C2 (sv) 2002-07-25 2002-07-25 Anordning vid två eller flera implantat försedda med tillväxtstimulerande substans(-er)
SE02023182 2002-07-25
PCT/SE2003/001109 WO2004010890A1 (en) 2002-07-25 2003-06-26 Arrangement of two or more implants provided with growth-stimulating substance(s)

Related Child Applications (1)

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US12/126,542 Division US8113834B2 (en) 2002-07-25 2008-05-23 Arrangement of two or more implants provided with growth-stimulating substance(s)

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US20060154202A1 true US20060154202A1 (en) 2006-07-13

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US10/521,113 Abandoned US20060154202A1 (en) 2002-07-25 2003-06-26 Arrangement of two or more implants provided with growth-stimulating substance(s)
US12/126,542 Expired - Fee Related US8113834B2 (en) 2002-07-25 2008-05-23 Arrangement of two or more implants provided with growth-stimulating substance(s)

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US12/126,542 Expired - Fee Related US8113834B2 (en) 2002-07-25 2008-05-23 Arrangement of two or more implants provided with growth-stimulating substance(s)

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US (2) US20060154202A1 (sv)
EP (1) EP1551327A1 (sv)
JP (1) JP2005533600A (sv)
AU (1) AU2003239089B2 (sv)
BR (1) BR0312904A (sv)
CA (1) CA2492736A1 (sv)
SE (1) SE522984C2 (sv)
WO (1) WO2004010890A1 (sv)

Cited By (1)

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US20110003852A1 (en) * 2007-02-23 2011-01-06 Soren Ebdrup N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase

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KR20160021307A (ko) 2007-07-10 2016-02-24 더 리전트 오브 더 유니버시티 오브 캘리포니아 선택된 조직에 조성물을 전달하는 물질 및 방법
EP2180843A1 (en) * 2007-07-24 2010-05-05 Universität Bern Device and method for periosteal distraction osteogenesis
US9861482B2 (en) 2008-08-26 2018-01-09 Andy Boiangiu Dental bone implant and implant method
US9259320B2 (en) 2008-08-26 2016-02-16 Andy Boiangiu Apparatus and method for bone augmentation
JP5218093B2 (ja) * 2009-01-23 2013-06-26 学校法人日本医科大学 骨増生治具及び骨増生キット
US20110300222A1 (en) * 2009-02-20 2011-12-08 The Regents Of The University Of California Luminescent porous silicon nanoparticles, methods of making and using same
US20100291508A1 (en) * 2009-05-13 2010-11-18 Jensen Ole T Biocompatible shell for bone treatment
US8882506B2 (en) * 2010-08-17 2014-11-11 Warsaw Orthopedic, Inc. Implant repair system and method
US9730771B2 (en) 2014-01-13 2017-08-15 Brock B. WESTOVER Endosseous dental implant assembly
GB2523827A (en) 2014-03-07 2015-09-09 Nobel Biocare Services Ag Dental implant
GB2523828A (en) 2014-03-07 2015-09-09 Nobel Biocare Services Ag Dental implant

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US4531916A (en) * 1983-07-08 1985-07-30 W. L. Gore & Associates, Inc. Dental implant with expanded PTFE gingival interface
US5683249A (en) * 1995-03-22 1997-11-04 Den-Mat Corporation Dental implant process and treated prosthetic
US7172422B1 (en) * 1997-07-09 2007-02-06 Holger K. Essiger Device for regenerating, repairing, and modeling human and animal bone, especially the jaw area for dental applications

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US6244868B1 (en) * 1997-12-10 2001-06-12 Douglas Alan Schappert Integrated guided-tissue-regeneration barrier for root-form dental implants
SE514323C2 (sv) * 1999-05-31 2001-02-12 Nobel Biocare Ab Implantat samt förfarande och användning vid implantat
SE514202C2 (sv) * 1999-05-31 2001-01-22 Nobel Biocare Ab På implantat till ben- eller vävnadsstruktur anordnat skikt samt sådant implantat och förfarande för applicering av skiktet
SE515695C2 (sv) * 1999-05-31 2001-09-24 Nobel Biocare Ab Implantat med beläggning av bentillväxtstimulerande substans för applicering i ben och förfarande vid sådant implantat
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Publication number Priority date Publication date Assignee Title
US4531916A (en) * 1983-07-08 1985-07-30 W. L. Gore & Associates, Inc. Dental implant with expanded PTFE gingival interface
US5683249A (en) * 1995-03-22 1997-11-04 Den-Mat Corporation Dental implant process and treated prosthetic
US7172422B1 (en) * 1997-07-09 2007-02-06 Holger K. Essiger Device for regenerating, repairing, and modeling human and animal bone, especially the jaw area for dental applications

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110003852A1 (en) * 2007-02-23 2011-01-06 Soren Ebdrup N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase

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Publication number Publication date
US20080228279A1 (en) 2008-09-18
CA2492736A1 (en) 2004-02-05
AU2003239089B2 (en) 2008-06-05
WO2004010890A1 (en) 2004-02-05
SE0202318D0 (sv) 2002-07-25
US8113834B2 (en) 2012-02-14
JP2005533600A (ja) 2005-11-10
BR0312904A (pt) 2005-07-05
EP1551327A1 (en) 2005-07-13
SE522984C2 (sv) 2004-03-23
SE0202318L (sv) 2004-01-26
AU2003239089A1 (en) 2004-02-16

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