US20020045737A1

US20020045737A1 - Enterococcus faecalis polynucleotides and polypeptides

Info

Publication number: US20020045737A1
Application number: US09/071,035
Authority: US
Inventors: Gil H. Choi; Camella Bailey; Alex Hromockyj; Charles A. Kunsch
Original assignee: Human Genome Sciences Inc
Current assignee: Human Genome Sciences Inc
Priority date: 1997-05-06
Filing date: 1998-05-04
Publication date: 2002-04-18
Anticipated expiration: 2018-05-04
Also published as: WO1998050555A3; WO1998050554A3; US6448043B1; US20030017495A1; CA2288944A1; US20050043528A1; AU7280598A; KR20010012236A; EP1002090A2; WO1998050555A2; US6913907B2; EP0981625A2; AU745787B2; JP2002529046A; CN1268178A; AU7279398A; CA2289116A1; AU735444B2; KR20010012223A; WO1998050554A2

Abstract

The present invention relates to novel genes from E. faecalis and the polypeptides they encode. Also provided as are vectors, host cells, antibodies and methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of E. faecalis polypeptide activity. The invention additionally relates to diagnostic methods for detecting Enterococcus nucleic acids, polypeptides and antibodies in a biological sample. The present invention further relates to novel vaccines for the prevention or attenuation of infection by Enterococcus.

Description

This application claims benefit of 35 U.S.C. section 119(e) based on copending U.S. Provisional Application No. 60/046,655, filed May 16, 1997; 60/044,031, filed May 16, 1997; and 60/066,099, filed Nov. 14, 1997. Provisional Application No. 60/066,099, filed Nov. 14, 1997 is herein incorporated by reference in its entirety.[0001]

FIELD OF THE INVENTION

The present invention relates to novel Enterococcus faecalis genes (E. faecalis) nucleic acids and polypeptides. Also provided are vectors, host cells and recombinant methods for producing the same. Further provided are diagnostic methods for detecting Enterococcus faecalis using probes, primers, and antibodies to the E. faecalis nucleic acids and polypeptides of the present invention. The invention further relates to screening methods for identifying agonists and antagonists of E. faecalis polypeptide activity and to vaccines using E. faecalis nucleic acids and polypeptides.

BACKGROUND OF THE INVENTION

Enterococci have been recognized as being pathogenic for humans since the turn of the century when they were first described by Thiercelin in 1988 as microscopic organisms. The genus Enterococcus includes the species Enterococcus faecalis or E. faecalis which is the most common pathogen in the group, accounting for 80-90 percent of all enterococcal infections. See Lewis et al. (1990) Eur J. Clin Microbiol Infect Dis.9:111-117.

The incidence of enterococcal infections has increased in recent years and enterococci are now the second most frequently reported nosocomial pathogens. Enterococcal infection is of particular concern because of its resistance to antibiotics. Recent attention has focused on enterococci not only because of their increasing role in nosocomial infections, but also because of their remarkable and increasing resistance to antimicrobial agents. These factors are mutually reinforcing since resistance allows enterococci to survive in an environment in which antimicrobial agents are heavily used; the hospital setting provides the antibiotics which eliminate or suppress susceptible bacteria, thereby providing a selective advantage for resistant organisms, and the hospital also provides the potential for dissemination of resistant enterococci via the usual routes of hand and environmental contamination.

Antimicrobial resistance can be divided into two general types, inherent or intrinsic property and that which is acquired. The genes for intrinsic resistance, like other species characteristics, appear to reside on the chromosome. Acquired resistance results from either a mutation in the existing DNA or acquisition of new DNA. The various inherent traits expressed by enterococci include resistance to semisynthetic penicillinase-resistant penicillins, cephalosporins, low levels of aminoglycosides, and low levels of clindamycin. Examples of acquired resistance include resistance to chloramphenicol, erythromycin, high levels of clindamycin, tetracycline, high levels of aminoglycosides, penicillin by means of penicillinase, fluoroquinolones, and vancomycin. Resistance to high levels of penicillin without penicillinase and resistance to fluoroquinolones are not known to be plasmid or transposon mediated and presumably are due to mutation(s).

Although the main reservoir for enterococci in humans is the gastrointestinal tract, the bacteria can also reside in the gallbladder, urethra and vagina.

E. faecalis has emerged as an important pathogen in endocarditis, bacteremia, urinary tract infections (UTIs), intraabdominal infections, soft tissue infections, and neonatal sepsis. See Lewis et al. (1990) supra. In the 1970s and 1980s enterococci became firmly established as major nosocomial pathogens. They are now the fourth leading cause of hospital-acquired infection and the third leading cause of bacteremia in the United States. Fatality ratios for enterococcal bactermia range from 12% to 68%, with death due to enterococcal sepsis in 4 to 50% of these cases. See T. G. Emori (1993) Clin. Microbiol. Rev. 6:428-442.

The ability of enterococci to colonize the gastrointestinal tract, plus the many intrinsic and acquired resistance traits, means that these organisms, which usually seem to have relatively low intrinsic virulence, are given an excellent opportunity to become secondary invaders. Since nosocomial isolates of enterococci have displayed resistance to essentially every useful antimicrobial agent, it will likely become increasingly difficult to successfully treat and control enterococcal infections. Particularly when the various resistance genes come together in a single strain, an event almost certain to occur at some time in the future.

The etiology of diseases mediated or exacerbated by Enterococcus faecalis, involves the programmed expression of E. faecalis genes, and that characterizing these genes and their patterns of expression would dramatically add to our understanding of the organism and its host interactions. Knowledge of the E. faecalis gene and genomic organization would improve our understanding of disease etiology and lead to improved and new ways of preventing, treating and diagnosing diseases. Thus, there is a need to characterize the genome of E. faecalis and for polynucleotides of this organism.

SUMMARY OF THE INVENTION

The present invention provides for isolated E. faecalis polynucleotides and polypeptides shown in Table 1 and SEQ ID NO:1 through SEQ ID NO:496 (polynucleotide sequences having odd SEQ ID NOs and polypeptide sequences having even SEQ ID NOs). One aspect of the invention provides isolated nucleic acid molecules comprising polynucleotides having a nucleotide sequence selected from the group consisting of: (a) a nucleotide sequence shown in Table 1; (b) a nucleotide sequence encoding any of the amino acid sequences of the polypeptides shown in Table 1; and (c) a nucleotide sequence complementary to any of the nucleotide sequences in (a) or (b). The invention further provides for fragments of the nucleic acid molecules of (a), (b) & (c) above.

Further embodiments of the invention include isolated nucleic acid molecules that comprise a polynucleotide having a nucleotide sequence at least 90% identical, and more preferably at least 95%, 96%, 97%, 98% or 99% identical, to any of the nucleotide sequences in (a), (b) or (c) above, or a polynucleotide which hybridizes under stringent hybridization conditions to a polynucleotide in (a), (b) or (c) above. Additional nucleic acid embodiments of the invention relate to isolated nucleic acid molecules comprising polynucleotides which encode the amino acid sequences of epitope-bearing portions of a E. faecalis polypeptide having an amino acid sequence in (a) above.

The present invention also relates to recombinant vectors, which include the isolated nucleic acid molecules of the present invention, and to host cells containing the recombinant vectors, as well as to methods of making such vectors and host cells. The present invention further relates to the use of these vectors in the production of E. faecalis polypeptides or peptides by recombinant techniques.

The invention further provides isolated E. faecalis polypeptides having an amino acid sequence selected from the group consisting of an amino acid sequence of any of the polypeptides described in Table 1 or fragments thereof.

The polypeptides of the present invention also include polypeptides having an amino acid sequence with at least 70% similarity, and more preferably at least 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% similarity to those described in Table 1, as well as polypeptides having an amino acid sequence at least 70% identical, more preferably at least 75% identical, and still more preferably 80%, 85%, 90%, 95%, 96%, 97%, 98%, or 99% identical to those above; as well as isolated nucleic acid molecules encoding such polypeptides.

The present invention further provides a single or multi-component vaccine comprising one or more of the E. faecalis polynucleotides or polypeptides described in Table 1, or fragments thereof, together with a pharmaceutically acceptable diluent, carrier, or excipient, wherein the E. faecalis polypeptide(s) are present in an amount effective to elicit an immune response to members of the Enterococcus genus. or at least E. faecalis, in an animal. The E. faecalis polypeptides of the present invention may further be combined with one or more immunogens of one or more other Enterococcal or non-Enterococcal organisms to produce a multi-component vaccine intended to elicit an immunological response against members of the Enterococcus genus and, optionally, one or more non-Enterococcal organisms.

The vaccines of the present invention can be administered in a DNA form, e.g., “naked” DNA, wherein the DNA encodes one or more Enterococcal polypeptides and, optionally, one or more polypeptides of a non-Enterococcal organism. The DNA encoding one or more polypeptides may be constructed such that these polypeptides are expressed as fusion proteins.

The vaccines of the present invention may also be administered as a component of a genetically engineered organism or host cell. Thus, a genetically engineered organism or host cell which expresses one or more E. faecalis polypeptides may be administered to an animal. For example, such a genetically engineered organism or host cell may contain one or more E. faecalis polypeptides of the present invention intracellularly, on its cell surface, or in its periplasmic space. Further, such a genetically engineered organism or host cell may secrete one or more E. faecalis polypeptides. The vaccines of the present invention may also be co-administered to an animal with an immune system modulator (e.g., CD86 and GM-CSF).

The invention also provides a method of inducing an immunological response in an animal to one or more members of the Enterococcus genus, preferably one or more isolates of the E. faecalis species, comprising administering to the animal a vaccine as described above.

The invention further provides a method of inducing a protective immune response in an animal, sufficient to prevent, attenuate, or control an infection by members of the Enterococcus genus, preferably at least E. faecalis species, comprising administering to the animal a composition comprising one or more of the polynucleotides or polypeptides described in Table 1, or fragments thereof. Further, these polypeptides, or fragments thereof, may be conjugated to another immunogen and/or administered in admixture with an adjuvant.

The invention further relates to antibodies elicited in an animal by the administration of one or more E. faecalis polypeptides of the present invention and to methods for producing such antibodies and fragments thereof. The invention further relates to recombinant antibodies and fragments thereof and to methods for producing such antibodies and fragments thereof.

The invention also provides diagnostic methods for detecting the expression of the polynucleotides of Table 1 by members of the Enterococcits genus in an animal. One such method involves assaying for the expression of a polynucleotide encoding E. faecalis polypeptides in a sample from an animal. This expression may be assaved either directly (e.g., by assaying polypeptide levels using antibodies elicited in response to amino acid sequences described in Table 1) or indirectly (e.g., by assaying for antibodies having specificity for amino acid sequences described in Table 1). The expression of polynucleotides can also be assayed by detecting the nucleic acids of Table 1. An example of such a method involves the use of the polymerase chain reaction (PCR) to amplify and detect Enterococcus nucleic acid sequences.

The present invention also relates to nucleic acid probes having all or part of a nucleotide sequence described in Table 1 (odd SEQ ID NOs) which are capable of hybridizing under stringent conditions to Enterococcus nucleic acids. The invention further relates to a method of detecting one or more Enterococcus nucleic acids in a biological sample obtained from an animal, said one or more nucleic acids encoding Enterococcus polypeptides, comprising: (a) contacting the sample with one or more of the above-described nucleic acid probes, under conditions such that hybridization occurs, and (b) detecting hybridization of said one or more probes to the Enterococczis nucleic acid present in the biological sample.

Other uses of the polypeptides of the present invention include: inter alia, to detect E. faecalis immunoassays, as epitope tags, as molecular weight markers on SDS-PAGE gels, as molecular weight markers for molecular sieve gel filtration columnns, to generate antibodies that specificaly bind E. faecalis polypeotides of the present invention for the detection E. faecalis in irrununoassays, to generate an immune response against E. faecalis and other Enterococczus species, and as vaccines against E. faecalis, other Enterococcus species and other bacteria genuses.

Isolated nucleic acid molecules of the present invention, particularly DNA molecules, are useful as probes for gene mapping and for identifying E. faecalis in a biological samples, for instance, by Southern and Northern blot analysis. Polynucleotides of the present invention are also useful in detecting E. faecalis by PCR using primers for a particular E. faecalis polynucleotide. Isolated polynucleotides of the present invention are also useful in making the polypeptides of the present invention.

DETAILED DESCRIPTION

The present invention relates to recombinant [0025] E. faecalis nucleic acids and fragments thereof. The present invention further relates to recombinant E. faecalis polypeptides and fragments thereof. The invention also relates to methods for using these polypeptides to produce immunological responses and to confer immunological protection to disease caused by members of the genus Entejococcus, at least isolates of the E. faecalis genus. The invention further relates to nucleic acid sequences which encode antigenic E. faecalis polypeptides and to methods for detecting E. faecalis nucleic acids and polypeptides in biological samples. The invention also relates to antibodies specific for the polypeptides and peptides of the present invention and methods for detecting such antibodies produced in a host animal.
Definitions [0026]
The following definitions are provided to clarify the subject matter which the inventors consider to be the present invention. [0027]
As used herein, the phrase “pathogenic agent” means an agent which causes a disease state or affliction in an animal. Included within this definition, for examples, are bacteria, protozoans, fungi, viruses and metazoan parasites which either produce a disease state or render an animal infected with such an organism susceptible to a disease state (e.g., a secondary infection). Further included are species and strains of the genus Enterococcus which produce disease states in animals. [0028]
As used herein, the term “organism” means any living biological system, including viruses, regardless of whether it is a pathogenic agent. [0029]
As used herein, the term “Enterococczs” means any species or strain of bacteria which is members of the genus Enterococcus. Such species and strains are known to those of skill in the art, and include those that are pathogenic and those that are not. [0030]
As used herein, the phrase “one or more [0031] E. faecalis polypeptides of the present invention” means polypeptides comprising the amino acid sequence of one or more of the E. faecalis polypeptides described in Table 1 (even SEQ ID NOs). These polypeptides may be expressed as fusion proteins wherein the E. faecalis polypeptides of the present invention are linked to additional amino acid sequences which may be of Enterococcal or non-Enterococcal origin. This phrase further includes polypeptide comprising fragments of the E. faecalis polypeptides of the present invention. Additional definitions are provided throughout the specification.
Explanation of Table 1 [0032]
Table 1, below, provides information describing genes which encode polypeptides of [0033] E. faecalis. The table lists the gene identifier which consists of the letters EF, which denote E. faecalis, followed immediately by a three digit numeric code, which arbitrarily number the E. faecalis genes of the present invention. A number from 1 through 4 follows the three digit number. A number 1 represents the full length open reading frame of the gene specified by the preceeding three digit number. A number 2 represents the full length potypeptide encoded by the gene specified the preceeding three digit number. A number 3 represents a polynucleotide fragment, of the gene represented by the preceeding three digit number, used to produce an antigenic polypeptide. A number 4 represents an antigenic polypeptide fragment, of the gene represented by the preceeding three digit number, used to stimulate an immune response or as a vaccine. The nucleotide and amino acid sequences of each gene and fragment are also shown in the Sequence Listing under the SEQ ID NO listed in Table 1.
Explanation of Table 2 [0034]
Table 2 lists accession numbers for the closest matching sequences between the polypeptides of the present invention and those available through GenBank and Derwent databases. These reference numbers are the database entry numbers commonly used by those of skill in the art, who will be familar with their denominations. The descriptions of the numenclature for GenBank are available from the National Center for Biotechnology Information. Column 1 lists the gene or ORF of the present invention. Column 2 lists the accession number of a “match” gene sequence in GenBank or Derwent databases. Column 3 lists the description of the “match” gene sequence. Columns 4 and 5 are the high score and smallest sum probability, respectively, calculated by BLAST. Polypeptides of the present invention that do not share significant identity/similarity with any polypeptide sequences of GenBank and Derwent are not represented in Table 2. Polypeptides of the present invention that share significant identity/similarity with more than one of the polypeptides of GenBank and Derwent are represented more than once. [0035]
Explanation of Table 3. [0036]
The [0037] E. faecalis polypeptides of the present invention may include one or more conservative amino acid substitutions from natural mutations or human manipulation as indicated in Table 3. Changes are preferably of a minor nature, such as conservative amino acid substitutions that do not significantly affect the folding or activity of the protein. Residues from the following groups, as indicated in Table 3, may be substituted for one another: Aromatic, Hydrophobic, Polar, Basic, Acidic, and Small,
Explanation of Table 4 [0038]
Table 4 lists residues comprising antigenic epitopes of antigenic epitope-bearing fragments present in each of the full length [0039] E. faecalis polypeptides described in Table 1 as predicted by the inventors using the algorithm of Jameson and Wolf, (1988) Comp. Appl. Biosci. 4:181-186. The Jameson-Wolf antigenic analysis was performed using the computer program PROTEAN (Version 3.11 for the Power MacIntosh, DNASTAR, Inc., 1228 South Park Street Madison, Wis.). E. faecalis polypeptide shown in Table 1 may one or more antigenic epitopes comprising residues described in Table 4. It will be appreciated that depending on the analytical criteria used to predict antigenic determinants, the exact address of the determinant may vary slightly. The residues and locations shown described in Table 4 correspond to the amino acid sequences for each full length gene sequence shown in Table 1 and in the Sequence Listing. Polypeptides of the present invention that do not have antigenic epitopes recognized by the Jameson-Wolf algorithm are not represented in Table 2.
Selection of Nucleic Acid Sequences Encoding Antigenic [0040] E. Faecalis Polypeptides
Sequenced [0041] E. faecalis genomic DNA was obtained from the E. faecalis strain V586. The E. faecalis strain V586 was deposited May 2, 1997 at the ATCC. 10801 University Blvd. Manassas, Va20110-2209, and given accession number 55969.
Some ORFs contained in the subset of fragments of the [0042] E. faecalis genome disclosed herein were derived through the use of a number of screening criteria detailed below. The ORFs are bounded at the amino terminus by a methionine or valine residue and usually at the carboxy terminus by a stop codon.
Most of the selected sequences consist of complete ORFs. The polypeptides that do not comprise a complete ORF can be determined by determining whether the corresponding polynucleotide sequence comprises a stop codon after the codon for the last amino acid residue in the polypeptide sequence. It is not always preferred to express a complete ORF in a heterologous system. It may be challenging to express and purify a highly hydrophobic protein by common laboratory methods. Some of the polypeptide vaccine candidates described herein have been modified slightly to simplify the production of recombinant protein. For example, nucleotide sequences which encode highly hydrophobic domains, such as those found at the amino terminal signal sequence, have been excluded from some constructs used for expression of the polypeptides. Furthermore, any highly hydrophobic amino acid sequences occurring at the carboxy terminus have also been excluded from the recombinant expression constructs. Thus, in one embodiment, a polypeptide which represents a truncated or modified ORF may be used as an antigen. [0043]
While numerous methods are known in the art for selecting potentially immunogenic polypeptides, many of the ORFs disclosed herein were selected on the basis of screening [0044] Enterococcus faecalis ORFs for several aspects of potential immunogenicity. One set of selection criteria are as follows:
1. Type I signal sequence: An amino terminal type I signal sequence generally directs a nascent protein across the plasma and outer membranes to the exterior of the bacterial cell. Experimental evidence obtained from studies with [0045] Escherichia coli suggests that the typical type I signal sequence consists of the following biochemical and physical attributes (Izard, J. W. and Kendall, D. A. Mol. Microbiol. 13:765-773 (1994)). The length of the type I signal sequence is approximately 15 to 25 primarily hydrophobic amino acid residues with a net positive charge in the extreme amino terminus. In addition, the central region of the signal sequence adopts an alpha-helical conformation in a hydrophobic environment. Finally, the region surrounding the actual site of cleavage is ideally six residues long, with small side-chain amino acids in the −1 and −3 positions.
2. Type IV signal sequence: The type IV signal sequence is an example of the several types of functional signal sequences which exist in addition to the type I signal sequence detailed above. Although functionally related, the type IV signal sequence possesses a unique set of biochemical and physical attributes (Strom, M. S. and Lory, S., [0046] J Bacteriol. 174:7345-7351 (1992)). These are typically six to eight amino acids with a net basic charge followed by an additional sixteen to thirty primarily hydrophobic residues. The cleavage site of a type IV signal sequence is typically after the initial six to eight amino acids at the extreme amino terminus. In addition, type IV signal sequences generally contain a phenylalanine residue at the +1 site relative to the cleavage site.
3. Lipoprotein: Studies of the cleavage sites of twenty-six bacterial lipoprotein precursors has allowed the definition of a consensus amino acid sequence for lipoprotein cleavage. Nearly three-fourths of the bacterial lipoprotein precursors examined contained the sequence L—(A,S)—(G,A)—C at positions −3 to +1, relative to the point of cleavage (Hayashi, S. and Wu, H. C., [0047] J Bioenerg. Biomembr. 22:451-471 (1 990)).
4. LPXTG motif: It has been experimentally determined that most anchored proteins found on the surface of gram-positive bacteria possess a highly conserved carboxy terminal sequence. More than fifty such proteins from organisms such as [0048] S. pyogenes, S. mutans, E. fa ecalis, S. pneumoniae, and others, have been identified based on their extracellular location and carboxy terminal amino acid sequence (Fischetti, V. A., ASM News 62:405-410 (1996)). The conserved region consists of six charged amino acids at the extreme carboxy terminus coupled to 15-20 hydrophobic amino acids presumed to function as a transmembrane domain. Immediately adjacent to the transmembrane domain is a six amino acid sequence conserved in nearly all proteins examined. The amino acid sequence of this region is L-P-X-T-G-X, where X is any amino acid.
An algorithm for selecting antigenic and immunogenic Enterococcis faecalis polypeptides including the foregoing criteria was developed. The algorithm is similar to that described in U.S. patent application Ser. No. 08/781,986, filed Jan. 3, 1997, which is fully incorporated by reference herein. Use of the algorithm by the inventors to select immunologically useful [0049] Enterococcus faecalis polypeptides resulted in the selection of a number of the disclosed ORFs. Polypeptides comprising the polypeptides identified in this group may be produced by techniques standard in the art and as further described herein.
Nucleic Acid Molecules [0050]
Sequenced [0051] E. faecalis genomic DNA was obtained from the E. faecalis strain V586. As discussed elsewhere hererin, polynucleotides of the present invention readily may be obtained by routine application of well known and standard procedures for cloning and sequencing DNA. Detailed methods for obtaining libraries and for sequencing are provided below, for instance. A wide variety of Enterococcus faecalis strains that can be used to prepare E. faecalis genomic DNA for cloning and for obtaining polynucleotides and polypeptides of the present invention. A wide variety of Enterococcus faecalis strains are available to the public from recognized depository institutions, such as the American Type Culture Collection (ATCC). It is recognized that minor variation is the nucleic acid and amino acid sequence may be expected from E. faecalis strain to strain. The present invention provides for genes, including both polynucleotides and polypeptides, of the of the present invention from all the Enterococcus faecalis strains.
Unless otherwise indicated, all nucleotide sequences determined by sequencing a DNA molecule herein were determined using an automated DNA sequencer (such as the Model 373 from Applied Biosystems, Inc., Foster City, Calif.), and all amino acid sequences of polypeptides encoded by DNA molecules determined herein were predicted by translation of a DNA sequence determined as above. Therefore, as is known in the art for any DNA sequence determined by this automated approach, any nucleotide sequence determined herein may contain some errors. Nucleotide sequences determined by automation are typically at least about 90% identical, more typically at least about 95% to at least about 99.9% identical to the actual nucleotide sequence of the sequenced DNA molecule. The actual sequence can be more precisely determined by other approaches including manual DNA sequencing methods well known in the art. As is also known in the art, a single insertion or deletion in a determined nucleotide sequence compared to the actual sequence will cause a frame shift in translation of the nucleotide sequence such that the predicted amino acid sequence encoded by a determined nucleotide sequence will be completely different from the amino acid sequence actually encoded by the sequenced DNA molecule, beginning at the point of such an insertion or deletion. In case of conflict between Table 1 and either the nucleic acid sequence of the clones listed in Table 1 or the amino acid sequence of the protein expressed by the clones listed in Table 1, the clones listed in Table 1 are controlling. By “nucleotide sequence” of a nucleic acid molecule or polynucleotide is intended to mean either a DNA or RNA sequence.Using the information provided herein, such as the nucleotide sequence in Table 1, a nucleic acid molecule of the present invention encoding a [0052] E. faecalis polypeptide may be obtained using standard cloning and screening procedures, such as those for cloning DNAs using genomic DNA as starting material. See, e.g., Sambrook et al. MOLECULAR CLONING: A LABORATORY MANUAL (Cold Spring Harbor, N.Y. 2nd ed. 1989); Ausubel et al., CURRENT PROTOCALS IN MOLECULAR BIOLOGY (John Wiley and Sons, N.Y. 1989). Illustrative of the invention, the nucleic acid molecule described in Table 1 was discovered in a DNA library derived from a E. faecalis genomic DNA.
Nucleic acid molecules of the present invention may be in the form of RNA, such as mRNA, or in the form of DNA, including, for instance, DNA and genomic DNA obtained by cloning or produced synthetically. The DNA may be double-stranded or single-stranded. Single-stranded DNA or RNA may be the coding strand, also known as the sense strand, or it may be the non-coding strand, also referred to as the anti-sense strand. [0053]
By “isolated” nucleic acid molecule(s) is intended a nucleic acid molecule. DNA or RNA, which has been removed from its native environment. This includes segments of DNA comprising the [0054] E. faecalis polynucleotides of the present invention isolated from the native chromosome. These fragments include both isolated fragments consisting only of E. faecalis DNA and fragments comprising heterologous sequences such as vector sequences or other foreign DNA. For example, recombinant DNA molecules contained in a vector are considered isolated for the purposes of the present invention. Further examples of isolated DNA molecules include recombinant DNA molecules maintained in heterologous host cells or purified (partially or substantially) DNA molecules in solution. Isolated RNA molecules include in vivo or in vitro RNA transcripts of the DNA molecules of the present invention. Isolated nucleic acid molecules according to the present invention further include such molecules produced synthetically.
In addition, isolated nucleic acid molecules of the invention include DNA molecules which comprise a sequence substantially different from those described above but which, due to the degeneracy of the genetic code, still encode a [0055] E. faecalis polypeptides and peptides of the present invention (e.g. polypeptides of Table 1). That is, all possible DNA sequences that encode the E. faecalis polypeptides of the present invention. This includes the genetic code and species-specific codon preferences known in the art. Thus, it would be routine for one skilled in the art to generate the degenerate variants described above, for instance, to optimize codon expression for a particular host (e.g., change codons in the bacteria mRNA to those preferred by a mammalian or other bacterial host such as E. coli).
The invention further provides isolated nucleic acid molecules having the nucleotide sequence shown in Table 1 or a nucleic acid molecule having a sequence complementary to one of the above sequences. Such isolated molecules, particularly DNA molecules, are useful as probes for gene mapping and for identifying [0056] E. faecalis in a biological sample, for instance, by PCR, Southern blot, Northern blot, or other form of hybridization analysis.
The present invention is further directed to nucleic acid molecules encoding portions or fragments of the nucleotide sequences described herein. Fragments include portions of the nucleotide sequences of Table 1, or the [0057] E. faecalis nucleotide sequences contained in the plasimd clones listed in Table 1, at least 10 contiguous nucleotides in length selected from any two integers, one of which representing a 5′ nucleotide position and a second of which representing a 3′ nucleotide position, where the first nucleotide for each nucleotide sequence in Table 1 is position 1. That is, every combination of a 5′ and 3′ nucleotide position that a fragment at least 10 contiguous nucleotides in length could occupy is included in the invention. At least means a fragment may be 10 contiguous nucleotide bases in length or any integer between 10 and the length of an entire nucleotide sequence of Table 1 minus 1. Therefore, included in the invention are contiguous fragments specified by any 5′ and 3′ nucleotide base positions of a nucleotide sequences of Table 1 wherein the contiguous fragment is any integer between 10 and the length of an entire nucleotide sequence minus 1.
Further, the invention includes polynucleotides comprising fragments specified by size, in nucleotides, rather than by nucleotide positions. The invention includes any fragment size, in contiguous nucleotides, selected from integers between 10 and the length of an entire nucleotide sequence minus 1. Preferred sizes of contiguous nucleotide fragments include 20 nucleotides, 30 nucleotides, 40 nucleotides, 50 nucleotides. Other preferred sizes of contiguous nucleotide fragments, which may be useful as diagnostic probes and primers, include fragments 50-300 nucleotides in length which include, as discussed above, fragment sizes representing each integer between 50-300. Larger fragments are also useful according to the present invention corresponding to most, if not all, of the nucleotide sequences shown in Table 1 or of the [0058] E. faecalis nucleotide sequences of the plasimd clones listed in Table 1. The preferred sizes are, of course, meant to exemplify not limit the present invention as all size fragments, representing any integer between 10 and the length of an entire nucleotide sequence minus 1, are included in the invention. Additional preferred nucleic acid fragments of the present invention include nucleic acid molecules encoding epitope-bearing portions of E. faecalis polypeptides identified in Table 4.
The present invention also provides for the exclusion of any fragment, specified by 5′ and 3′ base positions or by size in nucleotide bases as described above for any nucleotide sequence of Table 1 or the plasmid clones listed in Table 1. Any number of fragments of nucleotide sequences in Table 1 or the plasimd clones listed in Table 1, specified by 5′ and 3′ base positions or by size in nucleotides, as described above, may be excluded from the present invention. [0059]
In another aspect, the invention provides an isolated nucleic acid molecule comprising a polynucleotide which hybridizes under stringent hybridization conditions to a portion of a polynucleotide in a nucleic acid molecules of the invention described above, for instance, nucleotide sequences of Table 1 or the [0060] E. faecalis sequences of the plasimd clones listed in Table 1. By “stringent hybridization conditions” is intended overnight incubation at 42° C. in a solution comprising: 50% formamide, 5× SSC (150 mM NaCl, 15 mM trisodium citrate), 50 mM sodium phosphate (pH 7.6), 5× Denhardt's solution, 10% dextran sulfate, and 20 μg/ml denatured, sheared salmon sperm DNA, followed by washing the filters in 0.1× SSC at about 65° C.
By a polynucleotide which hybridizes to a “portion” of a polynucleotide is intended a polynucleotide (either DNA or RNA) hybridizing to at least about 15 nucleotides bases, and more preferably at least about 20 nucleotides bases, still more preferably at least about 30 nucleotides bases, and even more preferably about 30-70 (e.g., 50) nucleotides bases of the reference polynucleotide. These are useful as diagnostic probes and primers as discussed above. By a portion of a polynucleotide of “at least 20 nucleotides bases in length,” for example, is intended 20 or more contiguous nucleotides bases nucleotides from the nucleotide sequence of the reference polynucleotide (e.g., the nucleotide sequence as shown in Table 1). Portions of a polynucleotide which hybridizes to a nucleotide sequence in Table 1, which can be used as probes and primers, may also be precisely specified by 5′ and 3′ base positions or by size in nucleotide bases as described above or precisely excluded in the same manner. [0061]
The nucleic acid molecules of the present invention include those encoding the full length [0062] E. faecalis polypeptides of Table 1 and portions of the E. faecalis polypeptides of Table 1. Also included in the present invention are nucleic acids encoding the above full length sequences and further comprise additional sequences, such as those encoding an added secretory leader sequence such as a pre-, or pro- or prepro- protein sequence. Further included in the present invention are nucleic acids encoding the above full length sequences and portions thereof and further comprise additional heterologous amino acid sequences encoded by nucleic acid sequences from a different source.
Also included in the present invention are nucleic acids encoding the above protein sequences together with additional, non-coding sequences, including for example, but not limited to non-coding 5′ and 3′ sequences. These sequences include transcribed, non-translated sequences that may play a role in transcription, and mRNA processing, for example, ribosome binding and stability of mRNA. Also included in the present invention are additional coding sequences which provide additional functionalities. [0063]
Thus, a nucleotide sequence encoding a polypeptide may be fused to a marker sequence, such as a sequence encoding a peptide which facilitates purification of the fused polypeptide. In certain preferred embodiments of this aspect of the invention, the marker amino acid sequence is a hexa-histidine peptide, such as the tag provided in a pQE vector (QIAGEN, Inc., 9259 Eton Avenue, Chatsworth, Calif., 91311), among others, many of which are commercially available. For instance, hexa-histidine provides for convenient purification of the fusion protein. See Gentz et al. (1989) Proc. Natl. Acad. Sci. 86:821-24. The “HA” tag is another peptide useful for purification which corresponds to an epitope derived from the influenza hemagglutinin protein. See Wilson et al. (1 984) Cell 37:767. As discussed below, other such fusion proteins include the [0064] E. faecalis polypeptides of the present invention fused to Fc at the N- or C-terminus.
Variant and Mutant Polynucleotides [0065]
The present invention further relates to variants of the nucleic acid molecules which encode portions, analogs or derivatives of a [0066] E. faecalis polypeptides of Table 1 and variant polypeptides thereof including portions, analogs, and derivatives of the E. faecalis polypeptides. Variants may occur naturally, such as a natural allelic variant.
By an “allelic variant” is intended one of several alternate forms of a gene occupying a given locus on a chromosome of an organism. See, e.g., B. Lewin, Genes IV (1990). Non-naturally occurring variants may be produced using art-known mutagenesis techniques. [0067]
Such nucleic acid variants include those produced by nucleotide substitutions, deletions, or additions. The substitutions, deletions, or additions may involve one or more nucleotides. The variants may be altered in coding regions, non-coding regions, or both. Alterations in the coding regions may produce conservative or non-conservative amino acid substitutions, deletions or additions. Especially preferred among these are silent substitutions, additions and deletions, which do not alter the properties and activities of a [0068] E. faecalis protein of the present invention or portions thereof. Also especially preferred in this regard are conservative substitutions.
Such polypeptide variants include those produced by amino acid substitutions, deletions or additions. The substitutions, deletions, or additions may involve one or more residues. Alterations may produce conservative or non-conservative amino acid substitutions, deletions, or additions. Especially preferred among these are silent substitutions, additions and deletions, which do not alter the properties and activities of a [0069] E. faecalis protein of the present invention or portions thereof. Also especially preferred in this regard are conservative substitutions.
The present invention also relates to recombinant vectors, which include the isolated nucleic acid molecules of the present invention, and to host cells containing the recombinant vectors, as well as to methods of making such vectors and host cells and for using them for production of [0070] E. faecalis polypeptides or peptides by recombinant techniques.
The present application is directed to nucleic acid molecules at least 90%, 95%, 96%, 97%, 98% or 99% identical to a nucleic acid sequence shown in Table 1. The above nucleic acid sequences are included irrespective of whether they encode a polypeptide having [0071] E. faecalis activity. This is because even where a particular nucleic acid molecule does not encode a polypeptide having E. faecalis activity, one of skill in the art would still know how to use the nucleic acid molecule, for instance, as a hybridization probe. Uses of the nucleic acid molecules of the present invention that do not encode a polypeptide having E. faecalis activity include, inter alia, isolating an E. faecalis gene or allelic variants thereof from a DNA library, and detecting E. faecalis mRNA expression samples, environmental samples, suspected of containing E. faecalis by Northern Blot analysis.
Preferred, are nucleic acid molecules having sequences at least 90%, 95%, 96%, 97%, 98% or 99% identical to the nucleic acid sequence shown in Table 1, which do, in fact, encode a polypeptide having [0072] E. faecalis protein activity By “a polypeptide having E. faecalis activity” is intended polypeptides exhibiting activity similar, but not necessarily identical, to an activity of the E. faecalis protein of the invention, as measured in a particular biological assay suitable for measuring activity of the specified protein.
Due to the degeneracy of the genetic code, one of ordinary skill in the art will immediately recognize that a large number of the nucleic acid molecules having a sequence at least 90%, 95%, 96%, 97%, 98%, or 99% identical to the nucleic acid sequences shown in Table 1 will encode a polypeptide having [0073] E. faecalis protein activity. In fact, since degenerate variants of these nucleotide sequences all encode the same polypeptide, this will be clear to the skilled artisan even without performing the above described comparison assay. It will be further recognized in the art that, for such nucleic acid molecules that are not degenerate variants, a reasonable number will also encode a polypeptide having E. faecalis protein activity. This is because the skilled artisan is fully aware of amino acid substitutions that are either less likely or not likely to significantly effect protein function (e.g., replacing one aliphatic amino acid with a second aliphatic amino acid), as further described below.
The biological activity or function of the polypeptides of the present invention are expected to be similar or identical to polypeptides from other bacteria that share a high degree of structural identity/similarity. Tables 2 lists accession numbers and descriptions for the closest matching sequences of polypeptides available through Genbank and Derwent databases. It is therefore expected that the biological activity or function of the polypeptides of the present invention will be similar or identical to those polypeptides from other bacterial genuses, species, or strains listed in Table 2. [0074]
By a polynucleotide having a nucleotide sequence at least, for example, 95% “identical” to a reference nucleotide sequence of the present invention, it is intended that the nucleotide sequence of the polynucleotide is identical to the reference sequence except that the polynucleotide sequence may include up to five point mutations per each 100 nucleotides of the reference nucleotide sequence encoding the [0075] E. faecalis polypeptide. In other words, to obtain a polynucleotide having a nucleotide sequence at least 95% identical to a reference nucleotide sequence, up to 5% of the nucleotides in the reference sequence may be deleted, inserted, or substituted with another nucleotide. The query sequence may be an entire sequence shown in Table 1, the ORF (open reading frame), or any fragment specified as described herein.
As a practical matter, whether any particular nucleic acid molecule or polypeptide is at least 90%, 95%. 96%, 97%, 98% or 99% identical to a nucleotide sequence of the presence invention can be determined conventionally using known computer programs. A preferred method for determining the best overall match between a query sequence (a sequence of the present invention) and a subject sequence, also referred to as a global sequence alignment, can be determined using the FASTDB computer program based on the algorithm of Brutlag et al. See Brutlag et al. (1990) Comp. App. Biosci. 6:237-245. In a sequence alignment the query and subject sequences are both DNA sequences. An RNA sequence can be compared by first converting U's to T's. The result of said global sequence alignment is in percent identity. Preferred parameters used in a FASTDB alignment of DNA sequences to calculate percent identity are: Matrix=Unitary, k-tuple=4, Mismatch Penalty=1, Joining Penalty=30. Randomization Group Length=0, Cutoff Score=1, Gap Penalty=5, Gap Size Penalty 0.05, Window Size=500 or the lenght of the subject nucleotide sequence, whichever is shorter. [0076]
If the subject sequence is shorter than the query sequence because of 5′ or 3′ deletions, not because of internal deletions, a manual correction must be made to the results. This is because the FASTDB program does not account for 5′ and 3′ truncations of the subject sequence when calculating percent identity. For subject sequences truncated at the 5′ or 3′ ends, relative to the query sequence, the percent identity is corrected by calculating the number of bases of the query sequence that are 5′ and 3′ of the subject sequence, which are not matched/aligned, as a percent of the total bases of the query sequence. Whether a nucleotide is matched/aligned is determined by results of the FASTDB sequence alignment. This percentage is then subtracted from the percent identity, calculated by the above FASTDB program using the specified parameters, to arrive at a final percent identity score. This corrected score is what is used for the purposes of the present invention. Only nucleotides outside the 5′ and 3′ nucleotides of the subject sequence, as displayed by the FASTDB alignment, which are not matched/aligned with the query sequence, are calculated for the purposes of manually adjusting the percent identity score. [0077]
For example, a 90 nucleotide subject sequence is aligned to a 100 nucleotide query sequence to determine percent identity. The deletions occur at the 5′ end of the subject sequence and therefore, the FASTDB alignment does not show a matched/alignment of the first 10 nucleotides at 5′ end. The 10 unpaired nucleotides represent 10% of the sequence (number of nucleotides at the 5′ and 3′ ends not matched/total number of nucleotides in the query sequence) so 10% is subtracted from the percent identity score calculated by the FASTDB program. If the remaining 90 nucleotides were perfectly matched the final percent identity would be 90%. In another example, a 90 nucleotide subject sequence is compared with a 100 nucleotide query sequence. This time the deletions are internal deletions so that there are no nucleotides on the 5′ or 3′ of the subject sequence which are not matched/aligned with the query. In this case the percent identity calculated by FASTDB is not manually corrected. Once again, only nucleotides 5′ and 3′ of the subject sequence which are not matched/aligned with the query sequence are manually corrected for. No other manual corrections are to made for the purposes of the present invention. [0078]
Vectors and Host Cell [0079]
The present invention also relates to vectors which include the isolated DNA molecules of the present invention, host cells comprising the recombinant vectors, and the production of [0080] E. faecalis polypeptides and peptides of the present invention expressed by the host cells.
Recombinant constructs may be introduced into host cells using well known techniques such as infection, transduction, transfection, transvection, electroporation and transformation. The vector may be, for example, a phage, plasmid, viral or retroviral vector. Retroviral vectors may be replication competent or replication defective. In the latter case, viral propagation generally will occur only in complementing host cells. [0081]
The polynucleotides may be joined to a vector containing a selectable marker for propagation in a host. Generally, a plasmid vector is introduced in a precipitate, such as a calcium phosphate precipitate, or in a complex with a charged lipid. If the vector is a virus, it may be packaged in vitro using an appropriate packaging cell line and then transduced into host cells. [0082]
Preferred are vectors comprising cis-acting control regions to the polynucleotide of interest. Appropriate trans-acting factors may be supplied by the host, supplied by a complementing vector or supplied by the vector itself upon introduction into the host. [0083]
In certain preferred embodiments in this regard, the vectors provide for specific expression, which may be inducible and/or cell type-specific. Particularly preferred among such vectors are those inducible by environmental factors that are easy to manipulate, such as temperature and nutrient additives. [0084]
Expression vectors useful in the present invention include chromosomal-, episomal- and virus-derived vectors, e.g., vectors derived from bacterial plasmids, bacteriophage, yeast episomes, yeast chromosomal elements, viruses such as baculoviruses, papova viruses, vaccinia viruses, adenoviruses, fowl pox viruses, pseudorabies viruses and retroviruses, and vectors derived from combinations thereof, such as cosmids and phagemids. [0085]
The DNA insert should be operatively linked to an appropriate promoter, such as the phage lambda PL promoter, the [0086] E. coli lac, Irp and tac promoters, the SV40 early and late promoters and promoters of retroviral LTRs, to name a few. Other suitable promoters will be known to the skilled artisan. The expression constructs will further contain sites for transcription initiation, termination and, in the transcribed region, a ribosome binding site for translation. The coding portion of the mature transcripts expressed by the constructs will preferably include a translation initiating site at the beginning and a termination codon (UAA, UGA or UAG) appropriately positioned at the end of the polypeptide to be translated.
As indicated, the expression vectors will preferably include at least one selectable marker. Such markers include dihydrofolate reductase or neomycin resistance for eukaryotic cell culture and tetracycline, kanamycin, or ampicillin resistance genes for culturing in [0087] E. coli and other bacteria. Representative examples of appropriate hosts include, but are not limited to, bacterial cells, such as E. coli, Streptomyces and Salmonella typhimurium cells; fungal cells, such as yeast cells; insect cells such as Drosophila S2 and Spodoptera Sf9 cells; animal cells such as CHO, COS and Bowes melanoma cells; and plant cells. Appropriate culture mediums and conditions for the above-described host cells are known in the art.
Among vectors preferred for use in bacteria include pQE70, pQE60 and pQE9, pQE10 available from Qiagen; pBS vectors, Phagescript vectors, Bluescript vectors, pNH8A, pNH16a, pNH18A, pNH46A available from Stratagene; pET series of vectors available from Novagen; and ptrc99a, pKK223-3, pKK233-3, pDR540, pRIT5 available from Pharmacia. Among preferred eukaryotic vectors are pWLNEO, pSV2CAT, pOG44, pXT1 and pSG available from Stratagene; and pSVK3, pBPV, pMSG and pSVL available from Pharmacia. Other suitable vectors will be readily apparent to the skilled artisan. [0088]
Among known bacterial promoters suitable for use in the present invention include the [0089] E. coli lacl and lacZ promoters, the T3, T5 and T7 promoters, the gpt promoter, the lambda PR and PL promoters and the trp promoter. Suitable eukaryotic promoters include the CMV immediate early promoter, the HSV thymidine kinase promoter, the early and late SV40 promoters, the promoters of retroviral LTRs, such as those of the Rous sarcoma virus (RSV), and metallothionein promoters, such as the mouse metallothionein-I promoter.
Introduction of the construct into the host cell can be effected by calcium phosphate transfection, DEAE-dextran mediated transfection, cationic lipid-mediated transfection, electroporation, transduction, infection or other methods. Such methods are described in many standard laboratory manuals (for example, Davis, et al., Basic [0090]
Methods In Molecular Biology (1986)). [0091]
Transcription of DNA encoding the polypeptides of the present invention by higher eukaryotes may be increased by inserting an enhancer sequence into the vector. Enhancers are cis-acting elements of DNA, usually about from 10 to 300 nucleotides that act to increase transcriptional activity of a promoter in a given host cell-type. Examples of enhancers include the SV40 enhancer, which is located on the late side of the replication origin at nucleotides 100 to 270, the cytomegalovirus early promoter enhancer, the polyoma enhancer on the late side of the replication origin, and adenovirus enhancers. [0092]
For secretion of the translated polypeptide into the lumen of the endoplasmic reticulum, into the periplasmic space or into the extracellular environment, appropriate secretion signals may be incorporated into the expressed polypeptide, for example, the amino acid sequence KDEL. The signals may be endogenous to the polypeptide or they may be heterologous signals. [0093]
The polypeptide may be expressed in a modified form, such as a fusion protein, and may include not only secretion signals, but also additional heterologous functional regions. For instance, a region of additional amino acids, particularly charged amino acids, may be added to the N-terminus of the polypeptide to improve stability and persistence in the host cell, during purification, or during subsequent handling and storage. Also, peptide moieties may be added to the polypeptide to facilitate purification. Such regions may be removed prior to final preparation of the polypeptide. The addition of peptide moieties to polypeptides to engender secretion or excretion, to improve stability and to facilitate purification, among others, are familiar and routine techniques in the art. A preferred fusion protein comprises a heterologous region from immunoglobulin that is useful to solubilize proteins. For example, EP-A-O 464 533 (Canadian counterpart 2045869) discloses fusion proteins comprising various portions of constant region of immunoglobulin molecules together with another human protein or part thereof. In many cases, the Fc part in a fusion protein is thoroughly advantageous for use in therapy and diagnosis and thus results, for example, in improved pharmacokinetic properties (EP-A 0232 262). On the other hand, for some uses it would be desirable to be able to delete the Fc part after the fusion protein has been expressed, detected and purified in the advantageous manner described. This is the case when Fc portion proves to be a hindrance to use in therapy and diagnosis, for example when the fusion protein is to be used as antigen for immunizations. In drug discovery, for example, human proteins, such as, hIL5-receptor has been fused with Fc portions for the purpose of high-throughput screening assays to identify antagonists of hIL-5. See Bennett, D. et al. (1995) J. Molec. Recogn. 8:52-58 and Johanson, K. et al. (1995) J. Biol. Chem. 270 (16):9459-9471. [0094]
The [0095] E. faecalis polypeptides can be recovered and purified from recombinant cell cultures by well-known methods including ammonium sulfate or ethanol precipitation, acid extraction, anion or cation exchange chromatography, phosphocellulose chromatography, hydrophobic interaction chromatography, affinity chromatography, hydroxylapatite chromatography, lectin chromatography and high performance liquid chromatography (“HPLC”) is employed for purification. Polypeptides of the present invention include naturally purified products, products of chemical synthetic procedures, and products produced by recombinant techniques from a prokaryotic or eukaryotic host. including, for example, bacterial, yeast, higher plant, insect and mammalian cells.
Polypeptides and Fragments [0096]
The invention further provides an isolated [0097] E. faecalis polypeptide having an amino acid sequence in Table 1, or a peptide or polypeptide comprising a portion of the above polypeptides.
Variant and Mutant Polypeptides [0098]
To improve or alter the characteristics of [0099] E. faecalis polypeptides of the present invention, protein engineering may be employed. Recombinant DNA technology known to those skilled in the art can be used to create novel mutant proteins or muteins including single or multiple amino acid substitutions, deletions, additions, or fusion proteins. Such modified polypeptides can show, e.g., enhanced activity or increased stability. In addition, they may be purified in higher yields and show better solubility than the corresponding natural polypeptide, at least under certain purification and storage conditions.
N-Terminal and C-Terminal Deletion Mutiants [0100]
It is known in the art that one or more amino acids may be deleted from the N-terminus or C-terminus without substantial loss of biological function. For instance, Ron et al. J. Biol. Chem., 268:2984-2988 (1993), reported modified KGF proteins that had heparin binding activity even if 3, 8, or 27 N-terminal amino acid residues were missing. Accordingly, the present invention provides polypeptides having one or more residues deleted from the amino terminus of the amino acid sequence of the [0101] E. faecalis polypeptides shown in Table 1, and polynucleotides encoding such polypeptides.
Similarly, many examples of biologically functional C-terminal deletion muteins are known. For instance, Interferon gamma shows up to ten times higher activities by deleting 8-10 amino acid residues from the carboxy terminus of the protein See, e.g., Dobeli, et al. (1988) J. Biotechnology 7:199-216. Accordingly, the present invention provides polypeptides having one or more residues from the carboxy terminus of the amino acid sequence of the [0102] E. faecalis polypeptides shown in Table 1. The invention also provides polypeptides having one or more amino acids deleted from both the amino and the carboxyl termini as described below.
The present invention is further directed to polynucleotide encoding portions or fragments of the amino acid sequences described herein as well as to portions or fragments of the isolated amino acid sequences described herein. Fragments include portions of the amino acid sequences of Table 1, are at least 5 contiguous amino acid in length, are selected from any two integers, one of which representing a N-terminal position. The initiation codon of the polypeptides of the present inventions position 1. Every combination of a N-terminal and C-terminal position that a fragment at least 5 contiguous amino acid residues in length could occupy, on any given amino acid sequence of Table 1 is included in the invention. At least means a fragment may be 5 contiguous amino acid residues in length or any integer between 5 and the number of residues in a full length amino acid sequence minus 1. Therefore, included in the invention are contiguous fragments specified by any N-terminal and C-terminal positions of amino acid sequence set forth in Table 1 wherein the contiguous fragment is any integer between 5 and the number of residues in a full length sequence minus 1. [0103]
Further, the invention includes polypeptides comprising fragments specified by size, in amino acid residues, rather than by N-terminal and C-terminal positions. The invention includes any fragment size, in contiguous amino acid residues, selected from integers between 5 and the number of residues in a full length sequence minus 1. Preferred sizes of contiguous polypeptide fragments include about 5 amino acid residues, about 10 amino acid residues, about 20 amino acid residues, about 30 amino acid residues, about 40 amino acid residues, about 50 amino acid residues, about 100 amino acid residues, about 200 amino acid residues, about 300 amino acid residues, and about 400 amino acid residues. The preferred sizes are, of course, meant to exemplify, not limit, the present invention as all size fragments representing any integer between 5 and the number of residues in a full length sequence minus 1 are included in the invention. The present invention also provides for the exclusion of any fragments specified by N-terminal and C-terminal positions or by size in amino acid residues as described above. Any number of fragments specified by N-terminal and C-terminal positions or by size in amino acid residues as described above may be excluded. [0104]
The above fragments need not be active since they would be useful, for example, in immunoassays, in epitope mapping, epitope tagging, to generate antibodies to a particular portion of the protein, as vaccines, and as molecular weight markers. [0105]
Other Mutants [0106]
In addition to N- and C-terminal deletion forms of the protein discussed above, it also will be recognized by one of ordinary skill in the art that some amino acid sequences of the [0107] E. faecalis polypeptide can be varied without significant effect of the structure or function of the protein. If such differences in sequence are contemplated, it should be remembered that there will be critical areas on the protein which determine activity.
Thus, the invention further includes variations of the [0108] E. faecalis polypeptides which show substantial E. faecalis polypeptide activity or which include regions of E. faecalis protein such as the protein portions discussed below. Such mutants include deletions, insertions, inversions, repeats, and type substitutions selected according to general rules known in the art so as to have little effect on activity. For example, guidance concerning how to make phenotypically silent amino acid substitutions is provided. There are two main approaches for studying the tolerance of an amino acid sequence to change. See, Bowie, J. U. et al. (1990), Science 247:1306-1310. The first method relies on the process of evolution, in which mutations are either accepted or rejected by natural selection. The second approach uses genetic engineering to introduce amino acid changes at specific positions of a cloned gene and selections or screens to identify sequences that maintain functionality.
These studies have revealed that proteins are surprisingly tolerant of amino acid substitutions. The studies indicate which amino acid changes are likely to be permissive at a certain position of the protein. For example, most buried amino acid residues require nonpolar side chains, whereas few features of surface side chains are generally conserved. Other such phenotypically silent substitutions are described by Bowie et al. (supra) and the references cited therein. Typically seen as conservative substitutions are the replacements, one for another, among the aliphatic amino acids Ala, Val, Leu and Ile; interchange of the hydroxyl residues Ser and Thr, exchange of the acidic residues Asp and Glu, substitution between the amide residues Asn and Gln, exchange of the basic residues Lys and Arg and replacements among the aromatic residues Phe, Tyr. [0109]
Thus, the fragment, derivative, analog, or homolog of the polypeptide of Table 1, or that encoded by the plaimds listed in Table 1, may be: (i) one in which one or more of the amino acid residues are substituted with a conserved or non-conserved amino acid residue (preferably a conserved amino acid residue) and such substituted amino acid residue may or may not be one encoded by the genetic code: or (ii) one in which one or more of the amino acid residues includes a substituent group: or (iii) one in which the [0110] E. faecalis polypeptide is fused with another compound, such as a compound to increase the half-life of the polypeptide (for example, polyethylene glycol): or (iv) one in which the additional amino acids are fused to the above form of the polypeptide, such as an IgG Fc fusion region peptide or leader or secretory sequence or a sequence which is employed for purification of the above form of the polypeptide or a proprotein sequence. Such fragments, derivatives and analogs are deemed to be within the scope of those skilled in the art from the teachings herein.
Thus, the [0111] E. faecalis polypeptides of the present invention may include one or more amino acid substitutions, deletions, or additions, either from natural mutations or human manipulation. As indicated, changes are preferably of a minor nature, such as conservative amino acid substitutions that do not significantly affect the folding or activity of the protein (see Table 3).
Amino acids in the [0112] E. faecalis proteins of the present invention that are essential for function can be identified by methods known in the art, such as site-directed mutagenesis or alanine-scanning mutagenesis. See, e.g., Cunningham et al. (1989) Science 244:1081-1085. The latter procedure introduces single alanine mutations at every residue in the molecule. The resulting mutant molecules are then tested for biological activity using assays appropriate for measuring the function of the particular protein.
Of special interest are substitutions of charged amino acids with other charged or neutral amino acids which may produce proteins with highly desirable improved characteristics, such as less aggregation. Aggregation may not only reduce activity but also be problematic when preparing pharmaceutical formulations, because aggregates can be immunogenic. See, e.g., Pinckard et al., (1967) Clin. Exp. Immunol. 2:331-340; Robbins, et al., (1987) Diabetes 36:838-845; Cleland, et al., (1993) Crit. Rev. Therapeutic Drug Carrier Systems 10:307-377. [0113]
The polypeptides of the present invention are preferably provided in an isolated form, and preferably are substantially purified. A recombinantly produced version of the [0114] E. faecalis polypeptide can be substantially purified by the one-step method described by Smith et al. (1988) Gene 67:31-40. Polypeptides of the invention also can be purified from natural or recombinant sources using antibodies directed against the polypeptides of the invention in methods which are well known in the art of protein purification.
The invention further provides for isolated [0115] E. faecalis polypeptides comprising an amino acid sequence selected from the group consisting of: (a) the amino acid sequence of a full-length E. faecalis polypeptide having the complete amino acid sequence shown in Table 1; (b) the amino acid sequence of a full-length E. faecalis polypeptide having the complete amino acid sequence shown in Table 1 excepting the N-terminal methionine; (c) the complete amino acid sequence encoded by the plaimds listed in Table 1; and (d) the complete amino acid sequence excepting the N-terminal methionine encoded by the plaimds listed in Table 1. The polypeptides of the present invention also include polypeptides having an amino acid sequence at least 80% identical, more preferably at least 90% identical, and still more preferably 95%, 96%, 97%, 98% or 99% identical to those described in (a), (b), (c), and (d) above.
Further polypeptides of the present invention include polypeptides which have at least 90% similarity, more preferably at least 95% similarity, and still more preferably at least 96%, 97%, 98% or 99% similarity to those described above. [0116]
A further embodiment of the invention relates to a polypeptide which comprises the amino acid sequence of a [0117] E. faecalis polypeptide having an amino acid sequence which contains at least one conservative amino acid substitution, but not more than 50 conservative amino acid substitutions, not more than 40 conservative amino acid substitutions, not more than 30 conservative amino acid substitutions, and not more than 20 conservative amino acid substitutions. Also provided are polypeptides which comprise the amino acid sequence of a E. faecalis polypeptide, having at least one, but not more than 10, 9, 8, 7, 6, 5, 4, 3, 2 or 1 conservative amino acid substitutions.
By a polypeptide having an amino acid sequence at least, for example, 95% “identical” to a query amino acid sequence of the present invention, it is intended that the amino acid sequence of the subject polypeptide is identical to the query sequence except that the subject polypeptide sequence may include up to five amino acid alterations per each 100 amino acids of the query amino acid sequence. In other words, to obtain a polypeptide having an amino acid sequence at least 95% identical to a query amino acid sequence, up to 5% of the amino acid residues in the subject sequence may be inserted, deleted, (indels) or substituted with another amino acid. These alterations of the reference sequence may occur at the amino or carboxy terminal positions of the reference amino acid sequence or anywhere between those terminal positions, interspersed either individually among residues in the reference sequence or in one or more contiguous groups within the reference sequence. [0118]
As a practical matter, whether any particular polypeptide is at least 90%, 95%, 96%, 97%, 98% or 99% identical to, for instance, the amino acid sequences shown in Table 1 or to the amino acid sequence encoded by the plaimds listed in Table 1 can be determined conventionally using known computer programs. A preferred method for determining the best overall match between a query sequence (a sequence of the present invention) and a subject sequence, also referred to as a global sequence alignment, can be determined using the FASTDB computer program based on the algorithm of Brutlag et al., (1990) Comp. App. Biosci. 6:237-245. In a sequence alignment the query and subject sequences are both amino acid sequences. The result of said global sequence alignment is in percent identity. Preferred parameters used in a FASTDB amino acid alignment are: Matrix=PAM 0, k-tuple=2, Mismatch Penalty=1, Joining Penalty=20, Randomization Group Length=0, Cutoff Score=1, Window Size=sequence length, Gap Penalty=5, Gap Size Penalty=0.05, Window Size=500 or the length of the subject amino acid sequence, whichever is shorter. [0119]
If the subject sequence is shorter than the query sequence due to N- or C-terminal deletions, not because of internal deletions, the results, in percent identity, must be manually corrected. This is because the FASTDB program does not account for N- and C-terminal truncations of the subject sequence when calculating global percent identity. For subject sequences truncated at the N- and C-termini, relative to the query sequence, the percent identity is corrected by calculating the number of residues of the query sequence that are N- and C-terminal of the subject sequence, which are not matched/aligned with a corresponding subject residue, as a percent of the total bases of the query sequence. Whether a residue is matched/aligned is determined by results of the FASTDB sequence alignment. This percentage is then subtracted from the percent identity, calculated by the above FASTDB program using the specified parameters, to arrive at a final percent identity score. This final percent identity score is what is used for the purposes of the present invention. Only residues to the N- and C-termini of the subject sequence, which are not matched/aligned with the query sequence, are considered for the purposes of manually adjusting the percent identity score. That is. only query amino acid residues outside the farthest N- and C-terminal residues of the subject sequence. [0120]
For example, a 90 amino acid residue subject sequence is aligned with a 100 residue query sequence to determine percent identity. The deletion occurs at the N-terminus of the subject sequence and therefore, the FASTDB alignment does not match/align with the first 10 residues at the N-terminus. The 10 unpaired residues represent 10% of the sequence (number of residues at the N- and C-termini not matched/total number of residues in the query sequence) so 10% is subtracted from the percent identity score calculated by the FASTDB program. If the remaining 90 residues were perfectly matched the final percent identity would be 90%. In another example, a 90 residue subject sequence is compared with a 100 residue query sequence. This time the deletions are internal so there are no residues at the N- or C-termini of the subject sequence which are not matched/aligned with the query. In this case the percent identity calculated by FASTDB is not manually corrected. Once again, only residue positions outside the N- and C-terminal ends of the subject sequence, as displayed in the FASTDB alignment, which are not matched/aligned with the query sequence are manually corrected. No other manual corrections are to made for the purposes of the present invention. [0121]
The above polypeptide sequences are included irrespective of whether they have their normal biological activity. This is because even where a particular polypeptide molecule does not have biological activity, one of skill in the art would still know how to use the polypeptide, for instance, as a vaccine or to generate antibodies. Other uses of the polypeptides of the present invention that do not have [0122] E. faecalis activity include, inter alia, as epitope tags, in epitope mapping, and as molecular weight markers on SDS-PAGE gels or on molecular sieve gel filtration columns using methods known to those of skill in the art.
As described below, the polypeptides of the present invention can also be used to raise polyclonal and monoclonal antibodies, which are useful in assays for detecting [0123] E. faecalis protein expression or as agonists and antagonists capable of enhancing or inhibiting E. Faecalis protein function. Further, such polypeptides can be used in the yeast two-hybrid system to “capture” E. faecalis protein binding proteins which are also candidate agonists and antagonists according to the present invention. See, e.g., Fields et al. (1989) Nature 340:245-246.
Epitope-Bearing Portions [0124]
In another aspect, the invention provides peptides and polypeptides comprising epitope-bearing portions of the [0125] E. faecalis polypeptides of the present invention. These epitopes are immunogenic or antigenic epitopes of the polypeptides of the present invention. An “immunogenic epitope” is defined as a part of a protein that elicits an antibody response when the whole protein or polypeptide is the immunogen. These immunogenic epitopes are believed to be confined to a few loci on the molecule. On the other hand, a region of a protein molecule to which an antibody can bind is defined as an “antigenic determinant” or “antigenic epitope.” The number of immunogenic epitopes of a protein generally is less than the number of antigenic epitopes. See, e.g., Geysen, et al. (1983) Proc. Natl. Acad. Sci. USA 81:3998-4002. Predicted antigenic epitopes are shown in Table 4, below. It is pointed out that Table 4 only lists amino acid residues comprising epitopes predicted to have the highest degree of antigenicity. The polypeptides not listed in Table 4 and portions of polypeptides not listed in Table 4 are not considered non-antigenic. This is because they may still be antigenic in vivo but merely not recognized as such by the particular algorithm used. Thus, Table 4 lists the amino acid residues comprising preferred antigenic epitopes but not a complete list. Amino acid residues comprising other antigenic epitopes may be determined by algorithms similar to the Jameson-Wolf analysis or by in vivo testing for an antigenic response using the methods described herein or those known in the art.
As to the selection of peptides or polypeptides bearing an antigenic epitope (i.e., that contain a region of a protein molecule to which an antibody can bind), it is well known in that art that relatively short synthetic peptides that mimic part of a protein sequence are routinely capable of eliciting an antiserum that reacts with the partially mimicked protein. See. e.g., Sutcliffe, et al., (1983) Science 219:660-666. Peptides capable of eliciting protein-reactive sera are frequently represented in the primary sequence of a protein, can be characterized by a set of simple chemical rules, and are confined neither to immunodominant regions of intact proteins (i.e., immunogenic epitopes) nor to the amino or carboxyl terminals. Peptides that are extremely hydrophobic and those of six or fewer residues generally are ineffective at inducing antibodies that bind to the mimicked protein; longer, peptides, especially those containing proline residues, usually are effective. See. Sutcliffe, et al., supra, p. 661. For instance, 18 of 20 peptides designed according to these guidelines, containing 8-39 residues covering 75% of the sequence of the influenza virus hemagglutinin HA1 polypeptide chain, induced antibodies that reacted with the HA1 protein or intact virus; and 12/12 peptides from the MuLV polymerase and 18/18 from the rabies glycoprotein induced antibodies that precipitated the respective proteins. [0126]
Antigenic epitope-bearing peptides and polypeptides of the invention are therefore useful to raise antibodies, including monoclonal antibodies, that bind specifically to a polypeptide of the invention. Thus, a high proportion of hybridomas obtained by fusion of spleen cells from donors immunized with an antigen epitope-bearing peptide generally secrete antibody reactive with the native protein. See Sutcliffe, et al., supra, p. 663. The antibodies raised by antigenic epitope-bearing peptides or polypeptides are useful to detect the mimicked protein, and antibodies to different peptides may be used for tracking the fate of various regions of a protein precursor which undergoes post-translational processing. The peptides and anti-peptide antibodies may be used in a variety of qualitative or quantitative assays for the mimicked protein, for instance in competition assays since it has been shown that even short peptides (e.g., about 9 amino acids) can bind and displace the larger peptides in immunoprecipitation assays. See, e.g., Wilson, et al., (1984) Cell 37:767-778. The anti-peptide antibodies of the invention also are useful for purification of the mimicked protein, for instance, by adsorption chromatography using methods known in the art. [0127]
Antigenic epitope-bearing peptides and polypeptides of the invention designed according to the above guidelines preferably contain a sequence of at least seven, more preferably at least nine and most preferably between about 10 to about 50 amino acids (i.e. any integer between 7 and 50) contained within the amino acid sequence of a polypeptide of the invention. However, peptides or polypeptides comprising a larger portion of an amino acid sequence of a polypeptide of the invention, containing about 50 to about 100 amino acids, or any length up to and including the entire amino acid sequence of a polypeptide of the invention, also are considered epitope-bearing peptides or polypeptides of the invention and also are useful for inducing antibodies that react with the mimicked protein. Preferably, the amino acid sequence of the epitope-bearing peptide is selected to provide substantial solubility in aqueous solvents (i.e., the sequence includes relatively hydrophilic residues and highly hydrophobic sequences are preferably avoided); and sequences containing proline residues are particularly preferred. [0128]
Non-limiting examples of antigenic polypeptides or peptides that can be used to generate an enterococcal-specific immune response or antibodies include portions of the amino acid sequences identified in Table 1. More specifically, Table 4 discloses a list of non-limiting residues that are involved in the antigenicity of the epitope-bearing fragments of the present invention. Therefore, the present inventions provides for isolatd and purified antigenic epitope-bearing fragements of the polypeptides of the present invention comprising a peptide sequences of Table 4. The antigenic epitope-bearing fragments comprising a peptide sequence of Table 4 preferably contain a sequence of at least seven, more preferably at least nine and most preferably between about 10 to about 50 amino acids (i.e. any integer between 7 and 50) of a polypeptide of the present invention. That is, included in the present invention are antigenic polypeptides between the integers of 7 and 50 amino acid in length comprising one or more of the sequences of Table 4. Therefore, in most cases, the polypeptides of Table 4 make up only a portion of the antigenic polypeptide. All combinations of sequences between the integers of 7 and 50 amino acid in length comprising one or more of the sequences of Table 4 are included. The antigenic epitope-bearing fragements may be specified by either the number of contiguous amino acid residues or by specific N-terminal and C-terminal positions as described above for the polypeptide fragements of the present invention, wherein the initiation codon is residue 1. Any number of the described antigenic epitope-bearing fragements of the present invention may also be excluded from the present invention in the same manner. [0129]
The epitope-bearing peptides and polypeptides of the invention may be produced by any conventional means for making peptides or polypeptides including recombinant means using nucleic acid molecules of the invention. For instance, an epitope-bearing amino acid sequence of the present invention may be fused to a larger polypeptide which acts as a carrier during recombinant production and purification, as well as during immunization to produce anti-peptide antibodies. Epitope-bearing peptides also may be synthesized using known methods of chemical synthesis. For instance, Houghten has described a simple method for synthesis of large numbers of peptides, such as 10-20 mg of 248 different 13 residue peptides representing single amino acid variants of a segment of the HA1 polypeptide which were prepared and characterized (by ELISA-type binding studies) in less than four weeks (Houghten, R. A. Proc. Natl. Acad. Sci. USA 82:5131-5135 (1985)). This “Simultaneous Multiple Peptide Synthesis (SMPS)” process is further described in U.S. Pat. No. 4,631.211 to Houghten and coworkers (1986). In this procedure the individual resins for the solid-phase synthesis of various peptides are contained in separate solvent-permeable packets, enabling the optimal use of the many identical repetitive steps involved in solid-phase methods. A completely manual procedure allows 500-1000 or more syntheses to be conducted simultaneously (Houghten et al. (1985) Proc. Natl. Acad. Sci. 82:5131-5135 at 5134. [0130]
Epitope-bearing peptides and polypeptides of the invention are used to induce antibodies according to methods well known in the art. See, e.g., Sutcliffe, et al., supra;; Wilson, et al., supra;; and Bittle, et al. (1985) J. Gen. Virol. 66:2347-2354. Generally, animals may be immunized with free peptide; however, anti-peptide antibody titer may be boosted by coupling of the peptide to a macromolecular carrier, such as keyhole limpet hemacyanin (KLH) or tetanus toxoid. For instance, peptides containing cysteine may be coupled to carrier using a linker such as m-maleimidobenzoyl-N-hydroxysuccinimide ester (MBS), while other peptides may be coupled to carrier using a more general linking agent such as glutaraldehyde. Animals such as rabbits, rats and mice are immunized with either free or carrier-coupled peptides, for instance, by intraperitoneal and/or intradermal injection of emulsions containing about 100 μg peptide or carrier protein and Freund's adjuvant. Several booster injections may be needed, for instance, at intervals of about two weeks, to provide a useful titer of anti-peptide antibody which can be detected, for example, by ELISA assay using free peptide adsorbed to a solid surface. The titer of anti-peptide antibodies in serum from an immunized animal may be increased by selection of anti-peptide antibodies, for instance, by adsorption to the peptide on a solid support and elution of the selected antibodies according to methods well known in the art. [0131]
Immunogenic epitope-bearing peptides of the invention, i.e., those parts of a protein that elicit an antibody response when the whole protein is the immunogen, are identified according to methods known in the art. For instance, Geysen, et al., supra, discloses a procedure for rapid concurrent synthesis on solid supports of hundreds of peptides of sufficient purity to react in an ELISA. Interaction of synthesized peptides with antibodies is then easily detected without removing them from the support. In this manner a peptide bearing an immunogenic epitope of a desired protein may be identified routinely by one of ordinary skill in the art. For instance, the immunologically important epitope in the coat protein of foot-and-mouth disease virus was located by Geysen et al. supra with a resolution of seven amino acids by synthesis of an overlapping set of all 208 possible hexapeptides covering the entire 213 amino acid sequence of the protein. Then, a complete replacement set of peptides in which all 20 amino acids were substituted in turn at every position within the epitope were synthesized, and the particular amino acids conferring specificity for the reaction with antibody were determined. Thus, peptide analogs of the epitope-bearing peptides of the invention can be made routinely by this method. U.S. Pat. No. 4,708,781 to Geysen (1987) further describes this method of identifying a peptide bearing an immunogenic epitope of a desired protein. [0132]
Further still, U.S. Pat. No. 5,194,392, to Geysen (1990), describes a general method of detecting or determining the sequence of monomers (amino acids or other compounds) which is a topological equivalent of the epitope (i.e., a “mimotope”) which is complementary to a particular paratope (antigen binding site) of an antibody of interest. More generally, U.S. Pat. No. 4,433,092, also to Geysen (1989), describes a method of detecting or determining a sequence of monomers which is a topographical equivalent of a ligand which is complementary to the ligand binding site of a particular receptor of interest. Similarly, U.S. Pat. No. 5,480,971 to Houghten, R. A. et al. (1996) discloses linear C[0133] ₁-C₇-alkyl peralkylated oligopeptides and sets and libraries of such peptides, as well as methods for using such oligopeptide sets and libraries for determining the sequence of a peralkylated oligopeptide that preferentially binds to an acceptor molecule of interest. Thus, non-peptide analogs of the epitope-bearing peptides of the invention also can be made routinely by these methods. The entire disclosure of each document cited in this section on “Polypeptides and Fragments” is hereby incorporated herein by reference.
As one of skill in the art will appreciate, the polypeptides of the present invention and the epitope-bearing fragments thereof described above can be combined with parts of the constant domain of immunoglobulins (IgG), resulting in chimeric polypeptides. These fusion proteins facilitate purification and show an increased half-life in vivo. This has been shown, e.g., for chimeric proteins consisting of the first two domains of the human CD4-polypeptide and various domains of the constant regions of the heavy or light chains of mammalian immunoglobulins. (EPA 0,394,827; Traunecker et al. (1988) Nature 331:84-86. Fusion proteins that have a disulfide-linked dimeric structure due to the IgG part can also be more efficient in binding and neutralizing other molecules than a monomeric [0134] E. faecalis polypeptide or fragment thereof alone. See Fountoulakis et al. (1995) J. Biochem. 270:3958-3964. Nucleic acids encoding the above epitopes of E. faecalis polypeptides can also be recombined with a gene of interest as an epitope tag to aid in detection and purification of the expressed polypeptide.
Antibodies [0135]
[0136] E. faecalis protein-specific antibodies for use in the present invention can be raised against the intact E. faecalis protein or an antigenic polypeptide fragment thereof, which may be presented together with a carrier protein, such as an albumin, to an animal system (such as rabbit or mouse) or, if it is long enough (at least about 25 amino acids), without a carrier.
As used herein, the term “antibody” (Ab) or “monoclonal antibody” (Mab) is meant to include intact molecules, single chain whole antibodies, and antibody fragments. Antibody fragments of the present invention include Fab and F(ab′)2 and other fragments including single-chain Fvs (scFv) and disulfide-linked Fvs (sdFv). Also included in the present invention are chimeric and humanized monoclonal antibodies and polyclonal antibodies specific for the polypeptides of the present invention. The antibodies of the present invention may be prepared by any of a variety of methods. For example, cells expressing a polypeptide of the present invention or an antigenic fragment thereof can be administered to an animal in order to induce the production of sera containing polyclonal antibodies. For example, a preparation of [0137] E. faecalis polypeptide or fragment thereof is prepared and purified to render it substantially free of natural contaminants. Such a preparation is then introduced into an animal in order to produce polyclonal antisera of greater specific activity.
In a preferred method, the antibodies of the present invention are monoclonal antibodies or binding fragments thereof. Such monoclonal antibodies can be prepared using hybridoma technology. See, e.g. Harlow et al., ANTIBODIES: A LABORATORY MANUAL, (Cold Spring Harbor Laboratory Press, 2nd ed. 1988); Hammerling, et al., in: MONOCLONAL ANTIBODIES AND T-CELL HYBRIDOMAS 563-681 (Elsevier, N.Y., 1981). Fab and F(ab′)2 fragments may be produced by proteolytic cleavage, using enzymes such as papain (to produce Fab fragments) or pepsin (to produce F(ab′)2 fragments). Alternatively, [0138] E. faecalis polypeptide-binding fragments, chimeric, and humanized antibodies can be produced through the application of recombinant DNA technology or through synthetic chemistry using methods known in the art.
Alternatively, additional antibodies capable of binding to the polypeptide antigen of the present invention may be produced in a two-step procedure through the use of anti-idiotypic antibodies. Such a method makes use of the fact that antibodies are themselves antigens, and that, therefore, it is possible to obtain an antibody which binds to a second antibody. In accordance with this method, [0139] E. faecalis polypeptide-specific antibodies are used to immunize an animal, preferably a mouse. The splenocytes of such an animal are then used to produce hybridoma cells, and the hybridoma cells are screened to identify clones which produce an antibody whose ability to bind to the E. faecalis polypeptide-specific antibody can be blocked by the E. faecalis polypeptide antigen. Such antibodies comprise anti-idiotypic antibodies to the E. faecalis polypeptide-specific antibody and can be used to immunize an animal to induce formation of further E. faecalis polypeptide-specific antibodies.
Antibodies and fragements thereof of the present invention may be described by the portion of a polypeptide of the present invention recognized or specifically bound by the antibody. Antibody binding fragements of a polypeptide of the present invention may be described or specified in the same manner as for polypeptide fragements discussed above., i.e, by N-terminal and C-terminal positions or by size in contiguous amino acid residues. Any number of antibody binding fragments, of a polypeptide of the present invention, specified by N-terminal and C-terminal positions or by size in amino acid residues, as described above, may also be excluded from the present invention. Therefore, the present invention includes antibodies the specifically bind a particuarlly discribed fragement of a polypeptide of the present invention and allows for the exclusion of the same. [0140]
Antibodies and fragements thereof of the present invention may also be described or specified in terms of their cross-reactivity. Antibodies and fragements that do not bind polypeptides of any other species of Enterococcus other than [0141] E. faecalis are included in the present invention. Likewise, antibodies and fragements that bind only species of Enterococcus, i.e. antibodies and fragements that do not bind bacteria from any genus other than Enterococcus, are included in the present invention.
Diagnostic Assays [0142]
The present invention further relates to methods for assaying staphylococcal infection in an animal by detecting the expression of genes encoding staphylococcal polypeptides of the present invention. The methods comprise analyzing tissue or body fluid from the animal for Enterococcus-specific antibodies, nucleic acids, or proteins. Analysis of nucleic acid specific to Enterococcus is assayed by PCR or hybridization techniques using nucleic acid sequences of the present invention as either hybridization probes or primers. See, e.g., Sambrook et al. Molecular cloning: A Laboratory Manual (Cold Spring Harbor Laboratory Press, 2nd ed., 1989, page 54 reference); Eremeeva et al. (1994) J. Clin. Microbiol. 32:803-810 (describing differentiation among spotted fever group Rickettsiae species by analysis of restriction fragment length polymorphism of PCR-amplified DNA) and Chen et al. 1994 J. Clin. Microbiol. 32:589-595 (detecting B. burgdorferi nucleic acids via PCR). [0143]
Where diagnosis of a disease state related to infection with Enterococcus has already been made, the present invention is useful for monitoring progression or regression of the disease state whereby patients exhibiting enhanced Enterococcus gene expression will experience a worse clinical outcome relative to patients expressing these gene(s) at a lower level. [0144]
By “biological sample” is intended any biological sample obtained from an animal, cell line, tissue culture, or other source which contains Enterococcus polypeptide, MRNA, or DNA. Biological samples include body fluids (such as saliva, blood, plasma, urine, mucus, synovial fluid, etc.) tissues (such as muscle, skin, and cartilage) and any other biological source suspected of containing Enterococcus polypeptides or nucleic acids. Methods for obtaining biological samples such as tissue are well known in the art. [0145]
The present invention is useful for detecting diseases related to Enterococcus infections in animals. Preferred animals include monkeys, apes, cats, dogs, birds, cows, pigs, mice, horses, rabbits and humans. Particularly preferred are humans. [0146]
Total RNA can be isolated from a biological sample using any suitable technique such as the single-step guanidinium-thiocyanate-phenol-chloroform method described in Chomczynski et al. (1987) Anal. Biochem. 162:156-159. mRNA encoding Enterococcus polypeptides having sufficient homology to the nucleic acid sequences identified in Table 1 to allow for hybridization between complementary sequences are then assayed using any appropriate method. These include Northern blot analysis, S1 nuclease mapping, the polymerase chain reaction (PCR), reverse transcription in combination with the polymerase chain reaction (RT-PCR), and reverse transcription in combination with the ligase chain reaction (RT-LCR). [0147]
Northern blot analysis can be performed as described in Harada et al. (1990) Cell 63:303-312. Briefly, total RNA is prepared from a biological sample as described above. For the Northern blot, the RINA is denatured in an appropriate buffer (such as glyoxaludimethyl sulfoxide/sodium phosphate buffer), subjected to agarose gel electrophoresis, and transferred onto a nitrocellulose filter. After the RNAs have been linked to the filter by a UV linker, the filter is prehybridized in a solution containing formamide, SSC, Denhardt's solution, denatured salmon sperm, SDS, and sodium phosphate buffer. A [0148] E. faecalis polynucleotide sequence shown in Table 1 labeled according to any appropriate method (such as the ³²P-multiprimed DNA labeling system (Amersham)) is used as probe. After hybridization overnight, the filter is washed and exposed to x-ray film. DNA for use as probe according to the present invention is described in the sections above and will preferably at least 15 nucleotides in length.
S1 mapping can be performed as described in Fujita et al. (1987) Cell 49:357-367. To prepare probe DNA for use in S1 mapping, the sense strand of an above-described [0149] E. faecalis DNA sequence of the present invention is used as a template to synthesize labeled antisense DNA. The antisense DNA can then be digested using an appropriate restriction endonuclease to generate further DNA probes of a desired length. Such antisense probes are useful for visualizing protected bands corresponding to the target mRNA (i. e., mRNA encoding Enterococcus polypeptides).
Levels of mRNA encoding Enterococcus polypeptides are assayed, for e.g., using the RT-PCR method described in Makino et al. (1990) Technique 2:295-301. By this method, the radioactivities of the “amplicons” in the polyacrylamide gel bands are linearly related to the initial concentration of the target mRNA. Briefly, this method involves adding total RNA isolated from a biological sample in a reaction mixture containing a RT primer and appropriate buffer. After incubating for primer annealing, the mixture can be supplemented with a RT buffer, dNTPs, DTT, RNase inhibitor and reverse transcriptase. After incubation to achieve reverse transcription of the RNA, the RT products are then subject to PCR using labeled primers. Alternatively, rather than labeling the primers, a labeled dNTP can be included in the PCR reaction mixture. PCR amplification can be performed in a DNA thermal cycler according to conventional techniques. After a suitable number of rounds to achieve amplification, the PCR reaction mixture is electrophoresed on a polyacrylamide gel. After drying the gel, the radioactivity of the appropriate bands (corresponding to the mRNA encoding the Enterococcus polypeptides of the present invention) are quantified using an imaging analyzer. RT and PCR reaction ingredients and conditions, reagent and gel concentrations, and labeling methods are well known in the art. Variations on the RT-PCR method will be apparent to the skilled artisan. Other PCR methods that can detect the nucleic acid of the present invention can be found in PCR PRIMER: A LABORATORY MANUAL (C. W. Dieffenbach et al. eds., Cold Spring Harbor Lab Press, 1995). [0150]
The polynucleotides of the present invention, including both DNA and RNA, may be used to detect polynucleotides of the present invention or Enterococcal species including [0151] E. faecalis using bio chip technology. The present invention includes both high density chip arrays (>1000 oligonucleotides per cm²) and low density chip arrays (<1000 oligonucleotides per cm²). Bio chips comprising arrays of polynucleotides of the present invention may be used to detect Enterococcal species, including E. faecalis, in biological and environmental samples and to diagnose an animal, including humans, with an E. faecalis or other Enterococcal infection. The bio chips of the present invention may comprise polynucleotide sequences of other pathogens including bacteria, viral, parasitic, and fungal polynucleotide sequences, in addition to the polynucleotide sequences of the present invention, for use in rapid diffenertial pathogenic detection and diagnosis. The bio chips can also be used to monitor an E. faecalis or other Enterococcal infections and to monitor the genetic changes (deletions, insertions, mismatches, etc.) in response to drug therapy in the clinic and drug development in the laboratory. The bio chip technology comprising arrays of polynucleotides of the present invention may also be used to simultaneously monitor the expression of a multiplicity of genes, including those of the present invention. The polynucleotides used to comprise a selected array may be specified in the same manner as for the fragements, i.e, by their 5′ and 3′ positions or length in contigious base pairs and include from. Methods and particular uses of the polynucleotides of the present invention to detect Enterococcal species, including E. faecalis, using bio chip technology include those known in the art and those of: U.S. Pat. Nos. 5510270, 5545531, 5445934, 5677195, 5532128, 5556752, 5527681, 5451683, 5424186, 5607646, 5658732 and World Pat. Nos. WO/9710365. WO/9511995, WO/9743447, WO/9535505, each incorporated herein in their entireties.
Biosensors using the polynucleotides of the present invention may also be used to detect, diagnose, and monitor [0152] E. faecalis or other Enterococcal species and infections thereof. Biosensors using the polynucleotides of the present invention may also be used to detect particular polynucleotides of the present invention. Biosensors using the polynucleotides of the present invention may also be used to monitor the genetic changes (deletions, insertions, mismatches, etc.) in response to drug therapy in the clinic and drug development in the laboratory. Methods and particular uses of the polynucleotides of the present invention to detect Enterococcal species, including E. faecalis, using biosenors include those known in the art and those of: U.S. Pat. Nos 5721102, 5658732, 5631170, and World Pat. Nos. WO97/3501 1, WO/9720203, each incorporated herein in their entireties.
Thus, the present invention includes both bio chips and biosensors comprising polynucleotides of the present invention and methods of their use. [0153]
Assaying Enterococcius polypeptide levels in a biological sample can occur using any art-known method, such as antibody-based techniques. For example, Enterococcus polypeptide expression in tissues can be studied with classical immunohistological methods. In these, the specific recognition is provided by the primary antibody (polyclonal or monoclonal) but the secondary detection system can utilize fluorescent, enzyme, or other conjugated secondary antibodies. As a result, an immunohistological staining of tissue section for pathological examination is obtained. Tissues can also be extracted, e.g., with urea and neutral detergent, for the liberation of Enterococcus polypeptides for Western-blot or dot/slot assay. See, e.g., Jalkanen, M. et al. (1985) J. Cell. Biol. 101:976-985; Jalkanen, M. et al. (1987) J. Cell . Biol. 105:3087-3096. In this technique, which is based on the use of cationic solid phases, quantitation of a Enterococcus polypeptide can be accomplished using an isolated Enterococcus polypeptide as a standard. This technique can also be applied to body fluids. [0154]
Other antibody-based methods useful for detecting Enterococcus polypeptide gene expression include immunoassays, such as the ELISA and the radjoimmunoassay (RIA). For example, a Enterococcus polypeptide-specific monoclonal antibodies can be used both as an immunoabsorbent and as an enzyme-labeled probe to detect and quantify a Enterococcus polypeptide. The amount of a Enterococcus polypeptide present in the sample can be calculated by reference to the amount present in a standard preparation using a linear regression computer algorithm. Such an ELISA is described in lacobelli et al. (1988) Breast Cancer Research and Treatment 11:19-30. In another ELISA assay, two distinct specific monoclonal antibodies can be used to detect Enterococcus polypeptides in a body fluid. In this assay, one of the antibodies is used as the immunoabsorbent and the other as the enzyme-labeled probe. [0155]
The above techniques may be conducted essentially as a “one-step” or “two-step” assay. The “one-step” assay involves contacting the Enterococcus polypeptide with immobilized antibody and, without washing, contacting the mixture with the labeled antibody. The “two-step” assay involves washing before contacting the mixture with the labeled antibody. Other conventional methods may also be employed as suitable. It is usually desirable to immobilize one component of the assay system on a support, thereby allowing other components of the system to be brought into contact with the component and readily removed from the sample. Variations of the above and other immunological methods included in the present invention can also be found in Harlow et al., ANTIBODIES: A LABORATORY MANUAL, (Cold Spring Harbor Laboratory Press, 2nd ed. 1988). [0156]
Suitable enzyme labels include, for example, those from the oxidase group, which catalyze the production of hydrogen peroxide by reacting with substrate. Glucose oxidase is particularly preferred as it has good stability and its substrate (glucose) is readily available. Activity of an oxidase label may be assayed by measuring the concentration of hydrogen peroxide formed by the enzyme-labeled antibody/substrate reaction. Besides enzymes, other suitable labels include radioisotopes, such as iodine ([0157] ¹²⁵I, ¹²¹I), carbon (¹⁴C), sulphur (³⁵S), tritium (³H), indium (¹¹²In), and technetium (^99mTc), and fluorescent labels, such as fluorescein and rhodamine, and biotin.
Further suitable labels for the Enterococcus polypeptide-specific antibodies of the present invention are provided below. Examples of suitable enzyme labels include malate dehydrogenase, Enterococcal nuclease, delta-5-steroid isomerase, yeast-alcohol dehydrogenase, alpha-glycerol phosphate dehydrogenase, triose phosphate isomerase, peroxidase, alkaline phosphatase, asparaginase, glucose oxidase, beta-galactosidase, ribonuclease, urease, catalase, glucose-6-phosphate dehydrogenase, glucoamylase, and acetylcholine esterase. [0158]
Examples of suitable radioisotopic labels include [0159] ³H, ¹¹¹In, ¹²⁵I, ¹³¹I, ³²P, ³⁵S, ¹⁴C, ⁵¹Cr, ⁵⁷To, ⁵⁸Co, ⁵⁹Fe, ⁷⁵Se, ¹⁵²Eu, ⁹⁰Y, ⁶⁷Cu, ²¹⁷Ci, ²¹¹At, ²¹²Pb, ⁴⁷Sc, ¹⁰⁹Pd, etc. ¹¹¹In is a preferred isotope where in vivo imaging is used since its avoids the problem of dehalogenation of the ²⁵¹I or ¹³¹I-labeled monoclonal antibody by the liver. In addition, this radionucleotide has a more favorable gamma emission energy for imaging. See, e.g., Perkins et al. (1985) Eur. J. Nucl. Med. 10:296-301; Carasquillo et al. (1987) J. Nucl. Med. 28:281-287. For example, ¹¹¹In coupled to monoclonal antibodies with 1 (P isothiocyanatobenzyl)-DPTA has shown little uptake in non-tumors tissues, particularly the liver, and therefore enhances specificity of tumor localization. See, Esteban et al. (1987) J. Nucl. Med. 28:861-870.
Examples of suitable non-radioactive isotopic labels include [0160] ¹⁵⁷Gd, ⁵⁵Mn, ¹⁶²Dy, ⁵²Tr, and ⁵⁶Fe.
Examples of suitable fluorescent labels include an [0161] ¹⁵²Eu label, a fluorescein label, an isothiocyanate label, a rhodamine label, a phycoerythrin label, a phycocyanin label, an allophycocyanin label, an o-phthaldehyde label, and a fluorescamine label.
Examples of suitable toxin labels include, Pseudomonas toxin, diphtheria toxin, ricin, and cholera toxin. [0162]
Examples of chemiluminescent labels include a luminal label, an isoluminal label, an aromatic acridinium ester label. an imidazole label. an acridinium salt label, an oxalate ester label, a luciferin label, a luciferase label, and an aequorin label. [0163]
Examples of nuclear magnetic resonance contrasting agents include heavy metal nuclei such as Gd, Mn, and iron. [0164]
Typical techniques for binding the above-described labels to antibodies are provided by Kennedy et al. (1976) Clin. Chim. Acta 70:1-31, and Schurs et al. (1977) Clin. Chim. Acta 81:1-40. Coupling techniques mentioned in the latter are the glutaraldehyde method, the periodate method, the dimaleimide method, the m-maleimidobenzyl-N-hydroxy-succinimide ester method, all of which methods are incorporated by reference herein. [0165]
In a related aspect, the invention includes a diagnostic kit for use in screening serum containing antibodies specific against [0166] E. faecalis infection. Such a kit may include an isolated E. faecalis antigen comprising an epitope which is specifically immunoreactive with at least one anti-E. faecalis antibody. Such a kit also includes means for detecting the binding of said antibody to the antigen. In specific embodiments, the kit may include a recombinantly produced or chemically synthesized peptide or polypeptide antigen. The peptide or polypeptide antigen may be attached to a solid support.
In a more specific embodiment, the detecting means of the above-described kit includes a solid support to which said peptide or polypeptide antigen is attached. Such a kit may also include a non-attached reporter-labeled anti-human antibody. In this embodiment, binding of the antibody to the [0167] E. faecalis antigen can be detected by binding of the reporter labeled antibody to the anti-E. faecalis polypeptide antibody.
In a related aspect, the invention includes a method of detecting [0168] E. faecalis infection in a subject. This detection method includes reacting a body fluid, preferably serum, from the subject with an isolated E. faecalis antigen, and examining the antigen for the presence of bound antibody. In a specific embodiment, the method includes a polypeptide antigen attached to a solid support, and serum is reacted with the support. Subsequently, the support is reacted with a reporter-labeled anti-human antibody. The support is then examined for the presence of reporter-labeled antibody.
The solid surface reagent employed in the above assays and kits is prepared by known techniques for attaching protein material to solid support material, such as polymeric beads, dip sticks, 96-well plates or filter material. These attachment methods generally include non-specific adsorption of the protein to the support or covalent attachment of the protein, typically through a free amine group, to a chemically reactive group on the solid support, such as an activated carboxyl, hydroxyl, or aldehyde group. Alternatively, streptavidin coated plates can be used in conjunction with biotinylated antigen(s). [0169]
The polypeptides and antibodies of the present invention, including fragments thereof, may be used to detect Enterococcal species including [0170] E. faecalis using bio chip and biosensor technology. Bio chip and biosensors of the present invention may comprise the polypeptides of the present invention to detect antibodies, which specifically recognize Enterococcal species, including E. faecalis. Bio chip and biosensors of the present invention may also comprise antibodies which specifically recognize the polypeptides of the present invention to detect Enterococcal species, including E. faecalis or specific polypeptides of the present invention. Bio chips or biosensors comprising polypeptides or antibodies of the present invention may be used to detect Enterococcal species, including E. faecalis, in biological and environmental samples and to diagnose an animal, including humans, with an E. faecalis or other Enterococcal infection. Thus, the present invention includes both bio chips and biosensors comprising polypeptides or antibodies of the present invention and methods of their use.
The bio chips of the present invention may further comprise polypeptide sequences of other pathogens including bacteria, viral, parasitic, and fungal polypeptide sequences, in addition to the polypeptide sequences of the present invention, for use in rapid diffenertial pathogenic detection and diagnosis. The bio chips of the present invention may further comprise antibodies or fragements thereof specific for other pathogens including bacteria, viral, parasitic, and fungal polypeptide sequences, in addition to the antibodies or fragements thereof of the present invention, for use in rapid diffenertial pathogenic detection and diagnosis. The bio chips and biosensors of the present invention may also be used to monitor an [0171] E. faecalis or other Enterococcal infection and to monitor the genetic changes (amio acid deletions, insertions, substitutions, etc.) in response to drug therapy in the clinic and drug development in the laboratory. The bio chip and biosensors comprising polypeptides or antibodies of the present invention may also be used to simultaneously monitor the expression of a multiplicity of polypeptides, including those of the present invention. The polypeptides used to comprise a bio chip or biosensor of the present invention may be specified in the same manner as for the fragements, i.e, by their N-terminal and C-terminal positions or length in contigious amino acid residue. Methods and particular uses of the polypeptides and antibodies of the present invention to detect Enterococcal species, including E. faecalis, or specific polypeptides using bio chip and biosensor technology include those known in the art, those of the U.S. Pat. Nos. and World Pat. Nos. listed above for biochips and biosensors using polynucleotides of the present invention, and those of: U.S. Pat. Nos. 5658732, 5135852, 5567301, 5677196, 5690894 and World Pat. Nos. WO9729366, WO9612957, each incorporated herein in their entireties.
Treatment [0172]
Agonists and Antagonists—Assays and Molecules [0173]
The invention also provides a method of screening compounds to identify those which enhance or block the biological activity of the [0174] E. faecalis polypeptides of the present invention. The present invention further provides where the compounds kill or slow the growth of E. faecalis. The ability of E. faecalis antagonists, including E. faecalis ligands, to prophylactically or therapeutically block antibiotic resistance may be easily tested by the skilled artisan. See, e.g., Straden et al. (1997) J. Bacteriol. 179(1):9-16.
An agonist is a compound which increases the natural biological function or which functions in a manner similar to the polypeptides of the present invention, while antagonists decrease or eliminate such functions. Potential antagonists include small organic molecules, peptides, polypeptides, and antibodies that bind to a polypeptide of the invention and thereby inhibit or extinguish its activity. [0175]
The antagonists may be employed for instance to inhibit peptidoglycan cross bridge formation. Antibodies against [0176] E. faecalis may be employed to bind to and inhibit E. faecalis activity to treat antibiotic resistance. Any of the above antagonists may be employed in a composition with a pharmaceutically acceptable carrier.
Vaccines [0177]
The present invention also provides vaccines comprising one or more polypeptides of the present invention. Heterogeneity in the composition of a vaccine may be provided by combining [0178] E. faecalis polypeptides of the present invention. Multi-component vaccines of this type are desirable because they are likely to be more effective in eliciting protective immune responses against multiple species and strains of the Enterococcus genus than single polypeptide vaccines.
Multi-component vaccines are known in the art to elicit antibody production to numerous immunogenic components. See, e.g., Decker et al. (1996) J. Infect. Dis. 174:S270-275. In addition, a hepatitis B, diphtheria, tetanus, pertussis tetravalent vaccine has recently been demonstrated to elicit protective levels of antibodies in human infants against all four pathogenic agents. See, e.g., Aristegui, J. et al. (1997) Vaccine 15:7-9. [0179]
The present invention in addition to single-component vaccines includes multi-component vaccines. These vaccines comprise more than one polypeptide, immunogen or antigen. Thus, a multi-component vaccine would be a vaccine comprising more than one of the [0180] E. faecalis polypeptides of the present invention.
Further within the scope of the invention are whole cell and whole viral vaccines. Such vaccines may be produced recombinantly and involve the expression of one or more of the [0181] E. faecalis polypeptides described in Table 1. For example, the E. faecalis polypeptides of the present invention may be either secreted or localized intracellular, on the cell surface, or in the periplasmic space. Further, when a recombinant virus is used, the E. faecalis polypeptides of the present invention may, for example, be localized in the viral envelope, on the surface of the capsid, or internally within the capsid. Whole cells vaccines which employ cells expressing heterologous proteins are known in the art. See, e.g., Robinson, K. et al. (1997) Nature Biotech. 15:653-657; Sirard, J. et al. (1997) Infect. Immun. 65:2029-2033; Chabalgoity, J. et al. (1997) Infect. Immun. 65:2402-2412. These cells may be administered live or may be killed prior to administration. Chabalgoity, J. et al., supra, for example, report the successful use in mice of a live attenuated Salmonella vaccine strain which expresses a portion of a platyhelminth fatty acid-binding protein as a fusion protein on its cells surface.
A multi-component vaccine can also be prepared using techniques known in the art by combining one or more [0182] E. faecalis polypeptides of the present invention, or fragments thereof, with additional non-Enterococcal components (e.g., diphtheria toxin or tetanus toxin, and/or other compounds known to elicit an immune response). Such vaccines are useful for eliciting protective immune responses to both members of the Enterococcus genus and non-Enterococcal pathogenic agents.
The vaccines of the present invention also include DNA vaccines. DNA vaccines are currently being developed for a number of infectious diseases. See, et al., Boyer, et al. (1997) Nat. Med. 3:526-532; reviewed in Spier, R. (1996) Vaccine 14:1285-1288. Such DNA vaccines contain a nucleotide sequence encoding one or more [0183] E. faecalis polypeptides of the present invention oriented in a manner that allows for expression of the subject polypeptide. For example, the direct administration of plasmid DNA encoding B. burgdorgeri OspA has been shown to elicit protective immunity in mice against borrelial challenge. See, Luke et al. (1997) J. Infect. Dis. 175:91-97.
The present invention also relates to the administration of a vaccine which is co-administered with a molecule capable of modulating immune responses. Kim et al. (1997) Nature Biotech. 15:641-646, for example, report the enhancement of immune responses produced by DNA immunizations when DNA sequences encoding molecules which stimulate the immune response are co-administered. In a similar fashion, the vaccines of the present invention may be co-administered with either nucleic acids encoding immune modulators or the immune modulators themselves. These immune modulators include granulocyte macrophage colony stimulating factor (GM-CSF) and CD86. [0184]
The vaccines of the present invention may be used to confer resistance to Enterococcal infection by either passive or active immunization. When the vaccines of the present invention are used to confer resistance to Enterococcal infection through active immunization, a vaccine of the present invention is administered to an animal to elicit a protective immune response which either prevents or attenuates a Enterococcal infection. When the vaccines of the present invention are used to confer resistance to Enterococcal infection through passive immunization, the vaccine is provided to a host animal (e.g., human, dog, or mouse), and the antisera elicited by this antisera is recovered and directly provided to a recipient suspected of having an infection caused by a member of the Enierococcus genus. [0185]
The ability to label antibodies, or fragments of antibodies, with toxin molecules provides an additional method for treating Enterococcal infections when passive immunization is conducted. In this embodiment, antibodies, or fragments of antibodies, capable of recognizing the [0186] E. faecalis polypeptides disclosed herein, or fragments thereof, as well as other Enterococcus proteins, are labeled with toxin molecules prior to their administration to the patient. When such toxin derivatized antibodies bind to Enterococcus cells, toxin moieties will be localized to these cells and will cause their death.
The present invention thus concerns and provides a means for preventing or attenuating a Enterococcal infection resulting from organisms which have antigens that are recognized and bound by antisera produced in response to the polypeptides of the present invention. As used herein, a vaccine is said to prevent or attenuate a disease if its administration to an animal results either in the total or partial attenuation (i e., suppression) of a symptom or condition of the disease, or in the total or partial immunity of the animal to the disease. [0187]
The administration of the vaccine (or the antisera which it elicits) may be for either a “prophylactic” or “therapeutic” purpose. When provided prophylactically, the compound(s) are provided in advance of any symptoms of Enterococcal infection. The prophylactic administration of the compound(s) serves to prevent or attenuate any subsequent infection. When provided therapeutically, the compound(s) is provided upon or after the detection of symptoms which indicate that an animal may be infected with a member of the Enterococcus genus. The therapeutic administration of the compound(s) serves to attenuate any actual infection. Thus, the [0188] E. faecalis polypeptides, and fragments thereof, of the present invention may be provided either prior to the onset of infection (so as to prevent or attenuate an anticipated infection) or after the initiation of an actual infection.
The polypeptides of the invention, whether encoding a portion of a native protein or a functional derivative thereof, may be administered in pure form or may be coupled to a macromolecular carrier. Example of such carriers are proteins and carbohydrates. Suitable proteins which may act as macromolecular carrier for enhancing the immunogenicity of the polypeptides of the present invention include keyhole limpet hemacyanin (KLH) tetanus toxoid, pertussis toxin, bovine serum albumin, and ovalbumin. Methods for coupling the polypeptides of the present invention to such macromolecular carriers are disclosed in Harlow et al., ANTIBODIES: A LABORATORY MANUAL, (Cold Spring Harbor Laboratory Press, 2nd ed. 1988). [0189]
A composition is said to be “pharmacologically or physiologically acceptable” if its administration can be tolerated by a recipient animal and is otherwise suitable for administration to that animal. Such an agent is said to be administered in a “therapeutically effective amount” if the amount administered is physiologically significant. An agent is physiologically significant if its presence results in a detectable change in the physiology of a recipient patient. [0190]
While in all instances the vaccine of the present invention is administered as a pharmacologically acceptable compound, one skilled in the art would recognize that the composition of a pharmacologically acceptable compound varies with the animal to which it is administered. For example, a vaccine intended for human use will generally not be co-administered with Freund's adjuvant. Further, the level of purity of the [0191] E. faecalis polypeptides of the present invention will normally be higher when administered to a human than when administered to a non-human animal.
As would be understood by one of ordinary skill in the art, when the vaccine of the present invention is provided to an animal, it may be in a composition which may contain salts, buffers, adjuvants, or other substances which are desirable for improving the efficacy of the composition. Adjuvants are substances that can be used to specifically augment a specific immune response. These substances generally perform two functions: (1) they protect the antigen(s) from being rapidly catabolized after administration and (2) they nonspecifically stimulate immune responses. [0192]
Normally, the adjuvant and the composition are mixed prior to presentation to the immune system, or presented separately, but into the same site of the animal being immunized. Adjuvants can be loosely divided into several groups based upon their composition. These groups include oil adjuvants (for example, Freund's complete and incomplete), mineral salts (for example, AlK(SO[0193] ₄)₂, AlNa(SO₄)₂, AlNH₄(SO₄), silica, kaolin, and carbon), polynucleotides (for example, poly IC and poly AU acids), and certain natural substances (for example, wax D from Mycobacterium tuberculosis, as well as substances found in Corynebacterium parvum, or Bordetella pertussis, and members of the genus Brucella. Other substances useful as adjuvants are the saponins such as, for example, Quil A. (Superfos A/S, Denmark). Preferred adjuvants for use in the present invention include aluminum salts, such as AlK(SO₄)₂, AlNa(SO₄)₂, and AlNH₄(SO₄). Examples of materials suitable for use in vaccine compositions are provided in REMINGTON'S PHARMACEUTICAL SCIENCES 1324-1341 (A. Osol, ed, Mack Publishing Co, Easton, Pa., (1980) (incorporated herein by reference).
The therapeutic compositions of the present invention can be administered parenterally by injection, rapid infusion, nasopharyngeal absorption (intranasopharangeally), dermoabsorption, or orally. The compositions may alternatively be administered intramuscularly, or intravenously. Compositions for parenteral administration include sterile aqueous or non-aqueous solutions, suspensions, and emulsions. Examples of non-aqueous solvents are propylene glycol, polyethylene glycol, vegetable oils such as olive oil, and injectable organic esters such as ethyl oleate. Carriers or occlusive dressings can be used to increase skin permeability and enhance antigen absorption. Liquid dosage forms for oral administration may generally comprise a liposome solution containing the liquid dosage form. Suitable forms for suspending liposomes include emulsions, suspensions, solutions, syrups, and elixirs containing inert diluents commonly used in the art, such as purified water. Besides the inert diluents, such compositions can also include adjuvants, wetting agents, emulsifying and suspending agents, or sweetening, flavoring, or perfuming agents. [0194]
Therapeutic compositions of the present invention can also be administered in encapsulated form. For example, intranasal immunization using vaccines encapsulated in biodegradable microsphere composed of poly(DL-lactide-co-glycolide). See, Shahin, R. et al. (1995) Infect. Immun. 63:1195-1200. Similarly, orally administered encapsulated [0195] Salmonella typhimurium antigens can also be used. Allaoui-Attarki, K. et al. (1997) Infect. Immun. 65:853-857. Encapsulated vaccines of the present invention can be administered by a variety of routes including those involving contacting the vaccine with mucous membranes (e.g., intranasally, intracolonicly, intraduodenally).
Many different techniques exist for the timing of the immunizations when a multiple administration regimen is utilized. It is possible to use the compositions of the invention more than once to increase the levels and diversities of expression of the immunoglobulin repertoire expressed by the immunized animal. Typically, if multiple immunizations are given, they will be given one to two months apart. [0196]
According to the present invention, an “effective amount” of a therapeutic composition is one which is sufficient to achieve a desired biological effect. Generally, the dosage needed to provide an effective amount of the composition will vary depending upon such factors as the animal's or human's age, condition, sex, and extent of disease, if any, and other variables which can be adjusted by one of ordinary skill in the art. [0197]
The antigenic preparations of the invention can be administered by either single or multiple dosages of an effective amount. Effective amounts of the compositions of the invention can vary from 0.01-1,000 μg/ml per dose, more preferably 0.1-500 μg/ml per dose, and most preferably 10-300 μg/ml per dose. [0198]

Examples

Example 1

Isolation of a Selected DNA Clone From the Deposited Sample of [0199] E. Faecalis
Three approaches can be used to isolate a [0200] E. faecalis clone comprising a polynucleotide of the present invention from any E. faecalis genomic DNA library. The E. faecalis strain V586 has been deposited as a convienent source for obtaining a E. faecalis strain although a wide varity of strains E. faecalis strains can be used which are known in the art.
[0201] E. faecalis genomic DNA is prepared using the following method. A 20 ml overnight bacterial culture grown in a rich medium (e.g., Trypticase Soy Broth, Brain Heart Infusion broth or Super broth), pelleted, washed two times with TES (3 OmM Tris-pH 8.0, 25 mM EDTA, 50 mM NaCl), and resuspended in 5 ml high salt TES (2.5 M NaCl). Lysostaphin is added to final concentration of approx 50 μg/ml and the mixture is rotated slowly 1 hour at 37 C to make protoplast cells. The solution is then placed in incubator (or place in a shaking water bath) and warmed to 55 C. Five hundred micro liter of 20% sarcosyl in TES (final concentration 2%) is then added to lyse the cells. Next, guanidine HCl is added to a final concentration of 7M (3.69 g in 5.5 ml). The mixture is swirled slowly at 55 C for 60-90 min (solution should clear). A CsCl gradient is then set up in SW41 ultra clear tubes using 20 ml 5.7 M CsCl and overlaying with 2.85 M CsCl. The gradient is carefully overlayed with the DNA-containing GuHCl solution. The gradient is spun at 30,000 rpm, 20 C for 24 hr and the lower DNA band is collected. The volume is increased to 5 ml with TE buffer. The DNA is then treated with protease K (10 μg/ml) overnight at 37 C, and precipitated with ethanol. The precipitated DNA is resuspended in a desired buffer.
In the first method, a plasmid is directly isolated by screening a plasmid [0202] E. faecalis genomic DNA library using a polynucleotide probe corresponding to a polynucleotide of the present invention. Particularly, a specific polynucleotide with 30-40 nucleotides is synthesized using an Applied Biosystems DNA synthesizer according to the sequence reported. The oligonucleotide is labeled, for instance, with ³²P-γ-ATP using T4 polynucleotide kinase and purified according to routine methods. (See, e.g., Maniatis et al., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Press, Cold Spring, N.Y. (1982).) The library is transformed into a suitable host, as indicated above (such as XL-1 Blue (Stratagene)) using techniques known to those of skill in the art. See, e.g., Sambrook et al. MOLECULAR CLONING: A LABORATORY MANUAL (Cold Spring Harbor, N.Y. 2nd ed. 1989); Ausubel et al., CURRENT PROTOCALS IN MOLECULAR BIOLOGY (John Wiley and Sons, N.Y. 1989). The transformants are plated on 1.5% agar plates (containing the appropriate selection agent, e.g., ampicillin) to a density of about 150 transfornants (colonies) per plate. These plates are screened using Nylon membranes according to routine methods for bacterial colony screening. See, e.g., Sambrook et al. MOLECULAR CLONING: A LABORATORY MANUAL (Cold Spring Harbor, N.Y. 2nd ed. 1989); Ausubel et al., CURRENT PROTOCALS IN MOLECULAR BIOLOGY (John Wiley and Sons, N.Y. 1989) or other techniques known to those of skill in the art.
Alternatively, two primers of 15-25 nucleotides derived from the 5′ and 3′ ends of a polynucleotide of Table 1 are synthesized and used to amplify the desired DNA by PCR using a [0203] E. faecalis genomic DNA prep as a template. PCR is carried out under routine conditions, for instance, in 25 μl of reaction mixture with 0.5 μg of the above DNA template. A convenient reaction mixture is 1.5-5 mM MgCl₂, 0.01% (w/v) gelatin, 20 μM each of dATP, dCTP, dGTP, dTTP, 25 pmol of each primer and 0.25 Unit of Taq polymerase. Thirty five cycles of PCR (denaturation at 94° C. for 1 min; annealing at 55° C. for 1 min; elongation at 72° C. for 1 min) are performed with a Perkin-Elmer Cetus automated thermal cycler. The amplified product is analyzed by agarose gel electrophoresis and the DNA band with expected molecular weight is excised and purified. The PCR product is verified to be the selected sequence by subcloning and sequencing the DNA product.
Finally, overlapping oligos of the DNA sequences of Table 1 can be chemically synthesized and used to generate a nucleotide sequence of desired length using PCR methods known in the art. [0204]

Example 2(a)

Expression and Purification Enterococcal polypeptides in [0205] E. Coli
The bacterial expression vector pQE60 was used for bacterial expression of some of the polypeptide fragements used in the soft tissue and systemic infection models discussed below. (QIAGEN, Inc., 9259 Eton Avenue, Chatsworth, Calif., 91311). pQE60 encodes ampicillin antibiotic resistance (“Ampr”) and contains a bacterial origin of replication (“ori”), an IPTG inducible promoter, a ribosome binding site (“RBS”), six codons encoding histidine residues that allow affinity purification using nickel-nitrilo-tri-acetic acid (“Ni-NTA”) affinity resin (QIAGEN, Inc., supra) and suitable single restriction enzyme cleavage sites. These elements are arranged such that an inserted DNA fragment encoding a polypeptide expresses that polypeptide with the six His residues (i.e., a “6× His tag”) covalently linked to the carboxyl terminus of that polypeptide. [0206]
The DNA sequence encoding the desired portion of a [0207] E. faecalis protein of the present invention was amplified from E. faecalis genomic DNA using PCR oligonucleotide primers which anneal to the 5′ and 3′ sequences coding for the portions of the E. faecalis polynucleotide shown in Table 1. Additional nucleotides containing restriction sites to facilitate cloning in the pQE60 vector are added to the 5′ and 3′ sequences, respectively.
For cloning the mature protein, the 5′ primer has a sequence containing an appropriate restriction site followed by nucleotides of the amino terminal coding sequence of the desired [0208] E. faecalis polynucleotide sequence in Table 1. One of ordinary skill in the art would appreciate that the point in the protein coding sequence where the 5′ and 3′ primers begin may be varied to amplify a DNA segment encoding any desired portion of the complete protein shorter or longer than the mature form. The 3′ primer has a sequence containing an appropriate restriction site followed by nucleotides complementary to the 3′ end of the polypeptide coding sequence of Table 1, excluding a stop codon, with the coding sequence aligned with the restriction site so as to maintain its reading frame with that of the six His codons in the pQE60 vector.
The amplified [0209] E. faecalis DNA fragment and the vector pQE60 were digested with restriction enzymes which recognize the sites in the primers and the digested DNAs were then ligated together. The E. faecalis DNA was inserted into the restricted pQE60 vector in a manner which places the E. faecalis protein coding region downstream from the IPTG-inducible promoter and in-frame with an initiating AUG and the six histidine codons.
The ligation mixture was transformed into competent [0210] E. coli cells using standard procedures such as those described by Sambrook et al., supra. E. coli strain M15/rep4, containing multiple copies of the plasmid pREP4, which expresses the lac repressor and confers kanamycin resistance (“Kanr”), was used in carrying out the illustrative example described herein. This strain, which was only one of many that are suitable for expressing a E. faecalis polypeptide, is available commercially (QIAGEN, Inc., supra). Transformants were identified by their ability to grow on LB agar plates in the presence of ampicillin and kanamycin. Plasmid DNA was isolated from resistant colonies and the identity of the cloned DNA confirmed by restriction analysis, PCR and DNA sequencing.
Clones containing the desired constructs were grown overnight (“O/N”) in liquid culture in LB media supplemented with both ampicillin (100 μg/ml) and kanamycin (25 μg/ml). The O/N culture was used to inoculate a large culture, at a dilution of approximately 1:25 to 1:250. The cells were grown to an optical density at 600 nm (“OD600”) of between 0.4 and 0.6. Isopropyl-β-D-thiogalactopyranoside (“IPTG”) was then added to a final concentration of 1 mM to induce transcription from the lac repressor sensitive promoter, by inactivating the lacd repressor. Cells subsequently were incubated further for 3 to 4 hours. Cells then were harvested by centrifugation. [0211]
The cells were then stirred for 3-4 hours at 4° C. in 6 M guanidine-HCl, pH 8. The cell debris was removed by centrifugation, and the supernatant containing the [0212] E. faecalis polypeptide was loaded onto a nickel-nitrilo-tri-acetic acid (“Ni-NTA”) affinity resin column (QIAGEN, Inc., supra). Proteins with a 6× His tag bind to the Ni-NTA resin with high affinity were purified in a simple one-step procedure (for details see: The QlAexpressionist, 1995, QIAGEN, Inc., supra). Briefly the supernatant was loaded onto the column in 6 M guanidine-HCl, pH 8, the column was first washed with 10 volumes of 6 M guanidine-HCl, pH 8, then washed with 10 volumes of 6 M guanidine-HCl pH 6, and finally the E. faecalis polypeptide was eluted with 6 M guanidine-HCI, pH 5.
The purified protein was then renatured by dialyzing it against phosphate-buffered saline (PBS) or 50 mM Na-acetate, pH 6 buffer plus 200 mM NaCl. Alternatively, the protein could be successfully refolded while immobilized on the Ni-NTA column. The recommended conditions are as follows: renature using a linear 6M-1M urea gradient in 500 mM NaCl, 20% glycerol, 20 mM Tris/HCl pH 7.4, containing protease inhibitors. The renaturation should be performed over a period of 1.5 hours or more. After renaturation the proteins can be eluted by the addition of 250 mM immidazole. Immidazole was removed by a final dialyzing step against PBS or 50 mM sodium acetate pH 6 buffer plus 200 mM NaCl. The purified protein was stored at 4° C. or frozen at −80° C. [0213]
Some of the polypeptide of the present invention were prepared using a non-denaturing protein purification method. For these polypeptides, the cell pellet from each liter of culture was resuspended in 25 mls of Lysis Buffer A at 4° C. (Lysis Buffer A=50 mM Na-phosphate, 300 mM NaCl, 10 mM 2-mercaptoethanol, 10% Glycerol, pH 7.5 with 1 tablet of Complete EDTA-free protease inhibitor cocktail (Boehringer Mannheim #1873580) per 50 ml of buffer). Absorbance at 550 nm was approximately 10-20 O.D./ml. The suspension was then put through three freeze/thaw cycles from −70° C. (using a ethanol-dry ice bath) up to room temperature. The cells were lysed via sonication in short 10 sec bursts over 3 minutes at approximately 80 W while kept on ice. The sonicated sample was then centrifuged at 15,000 RPM for 30 minutes at 4° C. The supernatant was passed through a column containing 1.0 ml of CL-4B resin to pre-clear the sample of any proteins that may bind to agarose non-specifically, and the flow-through fraction was collected. [0214]
The pre-cleared flow-through was applied to a nickel-nitrilo-tri-acetic acid (“Ni-NTA”) affinity resin column (Quiagen, Inc., supra). Proteins with a 6× His tag bind to the Ni-NTA resin with high affinity and can be purified in a simple one-step procedure. Briefly, the supernatant was loaded onto the column in Lysis Buffer A at 4° C., the column was first washed with 10 volumes of Lysis Buffer A until the A280 of the eluate returns to the baseline. Then, the column was washed with 5 volumes of 40 mM Imidazole (92% Lysis Buffer A/8% Buffer B) (Buffer B=50 mM Na-Phosphate, 300 mM NaCl, 10% Glycerol, 10 mM 2-mercaptoethanol, 500 mM Imidazole, pH of the final buffer should be 7.5). The protein was eluted off of the column with a series of increasing Imidazole solutions made by adjusting the ratios of Lysis Buffer A to Buffer B. Three different concentrations were used: 3 volumes of 75 mM Imidazole, 3 volumes of 150 mM Imidazole, 5 volumes of 500 mM Imidazole. The fractions containing the purified protein were analyzed using 8%, 10% or 14% SDS-PAGE depending on the protein size. The purified protein was then dialyzed 2× against phosphate-buffered saline (PBS) in order to place it into an easily workable buffer. The purified protein was stored at 4° C. or frozen at −80°. [0215]
The following alternative method may be used to purify [0216] E. faecalis expressed in E. coli when it is present in the form of inclusion bodies. Unless otherwise specified, all of the following steps are conducted at 4-10° C.
Upon completion of the production phase of the [0217] E. coli fermentation, the cell culture is cooled to 4-1 0° C. and the cells are harvested by continuous centrifugation at 15,000 rpm (Heraeus Sepatech). On the basis of the expected yield of protein per unit weight of cell paste and the amount of purified protein required, an appropriate amount of cell paste, by weight, is suspended in a buffer solution containing 100 mM Tris. 50 mM EDTA, pH 7.4. The cells are dispersed to a homogeneous suspension using a high shear mixer.
The cells are then lysed by passing the solution through a microfluidizer (Microfuidics, Corp. or APV Gaulin, Inc.) twice at 4000-6000 psi. The homogenate is then mixed with NaCl solution to a final concentration of 0.5 M NaCl, followed by centrifugation at 7000× g for 15 min. The resultant pellet is washed again using 0.5 M NaCl, 100 mM Tris, 50 mM EDTA, pH 7.4. [0218]
The resulting washed inclusion bodies are solubilized with 1.5 M guanidine hydrochloride (GuHCl) for 2-4 hours. After 7000× g centrifugation for 15 min., the pellet is discarded and the [0219] E. faecalis polypeptide-containing supernatant is incubated at 4° C. overnight to allow further GuHCI extraction.
Following high speed centrifugation (30,000× g) to remove insoluble particles, the GuHCI solubilized protein is refolded by quickly mixing the GuHCl extract with 20 volumes of buffer containing 50 mM sodium, pH 4.5, 150 mM NaCl, 2 mM EDTA by vigorous stirring. The refolded diluted protein solution is kept at 4° C. without mixing for 12 hours prior to further purification steps. [0220]
To clarify the refolded [0221] E. faecalis polypeptide solution, a previously prepared tangential filtration unit equipped with 0.16 μm membrane filter with appropriate surface area (e.g., Filtron), equilibrated with 40 mM sodium acetate, pH 6.0 is employed. The filtered sample is loaded onto a cation exchange resin (e.g., Poros HS-50, Perseptive Biosystems). The column is washed with 40 mM sodium acetate, pH 6.0 and eluted with 250 mM, 500 mM, 1000 mM, and 1500 mM NaCl in the same buffer, in a stepwise manner. The absorbance at 280 mm of the effluent is continuously monitored. Fractions are collected and further analyzed by SDS-PAGE.
Fractions containing the [0222] E. faecalis polypeptide are then pooled and mixed with 4 volumes of water. The diluted sample is then loaded onto a previously prepared set of tandem columns of strong anion (Poros HQ-50, Perseptive Biosystems) and weak anion (Poros CM-20, Perseptive Biosystems) exchange resins. The columns are equilibrated with 40 mM sodium acetate, pH 6.0. Both columns are washed with 40 mM sodium acetate, pH 6.0, 200 mM NaCl. The CM-20 column is then eluted using a 10 column volume linear gradient ranging from 0.2 M NaCl, 50 mM sodium acetate, pH 6.0 to 1.0 M NaCl, 50 mM sodium acetate, pH 6.5. Fractions are collected under constant A₂₈₀monitoring of the effluent. Fractions containing the E. faecalis polypeptide (determined, for instance, by 16% SDS-PAGE) are then pooled.
The resultant [0223] E. faecalis polypeptide exhibits greater than 95% purity after the above refolding and purification steps. No major contaminant bands are observed from Commassie blue stained 16% SDS-PAGE gel when 5 μg of purified protein is loaded. The purified protein is also tested for endotoxin/LPS contamination, and typically the LPS content is less than 0.1 ng/ml according to LAL assays.

Example 2(b)

Alternative Expression and Purification Enterococcalpolypeptides in [0224] E. Coli
the vector pQE10 was alternatively used to clone and express some of the polypeptides of the present invention for use in the soft tissue and systemic infection models discussed below. The difference being such that an inserted DNA fragment encoding a polypeptide expresses that polypeptide with the six His residues (i.e., a “6× His tag”) covalently linked to the amino terminus of that polypeptide. The bacterial expression vector pQE10 (QIAGEN, Inc., 9259 Eton Avenue, Chatsworth, Calif., 91311) was used in this example. The components of the pQE10 plasmid are arranged such that the inserted DNA sequence encoding a polypeptide of the present invention expresses the polypeptide with the six His residues (i.e., a “6× His tag”)) covalently linked to the amino terminus. [0225]
The DNA sequences encoding the desired portions of a polypeptide of Table 1 were amplified using PCR oligonucleotide primers from genomic [0226] E. faecalis DNA. The PCR primers anneal to the nucleotide sequences encoding the desired amino acid sequence of a polypeptide of the present invention. Additional nucleotides containing restriction sites to facilitate cloning in the pQE 10 vector were added to the 5′ and 3′ primer sequences, respectively.
For cloning a polypeptide of the present invention, the 5′ and 3′ primers were selected to amplify their respective nucleotide coding sequences. One of ordinary skill in the art would appreciate that the point in the protein coding sequence where the 5′ and 3′ primers begins may be varied to amplify a DNA segment encoding any desired portion of a polypeptide of the present invention. The 5′ primer was designed so the coding sequence of the 6× His tag is aligned with the restriction site so as to maintain its reading frame with that of [0227] E. faecalis polypeptide. The 3′ was designed to include an stop codon. The amplified DNA fragment was then cloned, and the protein expressed, as described above for the pQE60 plasmid.
The DNA sequences encoding the amino acid sequences of Table 1 may also be cloned and expressed as fusion proteins by a protocol similar to that described directly above, wherein the pET-32b(+) vector (Novagen, 601 Science Drive, Madison, Wis. 53711) is preferentially used in place of pQE10. [0228]
The above methods are not limited to the polypeptide fragements actually produced. The above method, like the methods below, can be used to produce either full length polypeptides or desired fragements therof. [0229]

Example 2(c)

Alternative Expression and Pitriflcation of [0230] Enterococcal polypeptides in E. Coli
The bacterial expression vector pQE60 is used for bacterial expression in this example (QIAGEN, Inc., 9259 Eton Avenue, Chatsworth, Calif., 91311). However, in this example, the polypeptide coding sequence is inserted such that translation of the six His codons is prevented and, therefore, the polypeptide is produced with no 6× His tag. [0231]
The DNA sequence encoding the desired portion of the [0232] E. faecalis amino acid sequence is amplified from an E. faecalis genomic DNA prep the deposited DNA clones using PCR oligonucleotide primers which anneal to the 5′ and 3′ nucleotide sequences corresponding to the desired portion of the E. faecalis polypeptides. Additional nucleotides containing restriction sites to facilitate cloning in the pQE60 vector are added to the 5′ and 3′ primer sequences.
For cloning a [0233] E. faecalis polypeptides of the present invention, 5′ and 3′ primers are selected to amplify their respective nucleotide coding sequences. One of ordinary skill in the art would appreciate that the point in the protein coding sequence where the 5′ and 3′ primers begin may be varied to amplify a DNA segment encoding any desired portion of a polypeptide of the present invention. The 3′ and 5′ primers contain appropriate restriction sites followed by nucleotides complementary to the 5′ and 3′ ends of the coding sequence respectively. The 3′ primer is additionally designed to include an in-frame stop codon.
The amplified [0234] E. faecalis DNA fragments and the vector pQE60 are digested with restriction enzymes recognizing the sites in the primers and the digested DNAs are then ligated together. Insertion of the E. faecalis DNA into the restricted pQE60 vector places the E. faecalis protein coding region including its associated stop codon downstream from the IPTG-inducible promoter and in-frame with an initiating AUG. The associated stop codon prevents translation of the six histidine codons downstream of the insertion point.
The ligation mixture is transformed into competent [0235] E. coli cells using standard procedures such as those described by Sambrook et al. E. coli strain M15/rep4, containing multiple copies of the plasmid pREP4, which expresses the lac repressor and confers kanamycin resistance (“Kanr”), is used in carrying out the illustrative example described herein. This strain, which is only one of many that are suitable for expressing E. faecalis polypeptide, is available commercially (QIAGEN, Inc., supra). Transformants are identified by their ability to grow on LB plates in the presence of ampicillin and kanamycin. Plasmid DNA is isolated from resistant colonies and the identity of the cloned DNA confirmed by restriction analysis, PCR and DNA sequencing.
Clones containing the desired constructs are grown overnight (“O/N”) in liquid culture in LB media supplemented with both ampicillin (100 μg/ml) and kanamycin (25 μg/ml). The O/N culture is used to inoculate a large culture, at a dilution of approximately 1:25 to 1:250. The cells are grown to an optical density at 600 nm (“OD600”) of between 0.4 and 0.6. isopropyl-b-D-thiogalactopyranoside (“IPTG”) is then added to a final concentration of 1 mM to induce transcription from the lac repressor sensitive promoter, by inactivating the lacl repressor. Cells subsequently are incubated further for 3 to 4 hours. Cells then are harvested by centrifugation. [0236]
To purify the [0237] E. faecalis polypeptide, the cells are then stirred for 3-4 hours at 4° C. in 6 M guanidine-HCl, pH 8. The cell debris is removed by centrifugation, and the supernatant containing the E. faecalis polypeptide is dialyzed against 50 mM Na-acetate buffer pH 6, supplemented with 200 mM NaCl. Alternatively, the protein can be successfully refolded by dialyzing it against 500 mM NaCl, 20% glycerol, 25 mM Tris/HCl pH 7.4, containing protease inhibitors. After renaturation the protein can be purified by ion exchange, hydrophobic interaction and size exclusion chromatography. Alternatively, an affinity chromatography step such as an antibody column can be used to obtain pure E. faecalis polypeptide. The purified protein is stored at 4° C. or frozen at −80° C.
The following alternative method may be used to purify [0238] E. faecalis polypeptides expressed in E. coli when it is present in the form of inclusion bodies. Unless otherwise specified, all of the following steps are conducted at 4-10° C.
Upon completion of the production phase of the [0239] E. coli fermentation, the cell culture is cooled to 4-10° C. and the cells are harvested by continuous centrifugation at 15,000 rpm (Heraeus Sepatech). On the basis of the expected yield of protein per unit weight of cell paste and the amount of purified protein required, an appropriate amount of cell paste, by weight, is suspended in a buffer solution containing 100 mM Tris, 50 mM EDTA, pH 7.4. The cells are dispersed to a homogeneous suspension using a high shear mixer.
The cells ware then lysed by passing the solution through a microfluidizer (Microfuidics, Corp. or APV Gaulin, Inc.) twice at 4000-6000 psi. The homogenate is then mixed with NaCi solution to a final concentration of 0.5 M NaCl, followed by centrifugation at 7000× g for 15 min. The resultant pellet is washed again using 0.5 M NaCl, 100 mM Tris, 50 mM EDTA, pH 7.4. [0240]
The resulting washed inclusion bodies are solubilized with 1.5 M guanidine hydrochloride (GuHCl) for 2-4 hours. After 7000× g centrifugation for 15 min., the pellet is discarded and the [0241] E. faecalis polypeptide-containing supernatant is incubated at 4° C. overnight to allow further GuHCl extraction.
Following high speed centrifugation (30,000× g) to remove insoluble particles, the GuHCI solubilized protein is refolded by quickly mixing the GuHCl extract with 20 volumes of buffer containing 50 mM sodium, pH 4.5, 150 mM NaCl, 2 mM EDTA by vigorous stirring. The refolded diluted protein solution is kept at 4° C. without mixing for 12 hours prior to further purification steps. [0242]
To clarify the refolded [0243] E. faecalis polypeptide solution, a previously prepared tangential filtration unit equipped with 0.16 μm membrane filter with appropriate surface area (e.g., Filtron), equilibrated with 40 mM sodium acetate, pH 6.0 is employed. The filtered sample is loaded onto a cation exchange resin (e.g., Poros HS-50, Perseptive Biosystems). The column is washed with 40 mM sodium acetate. pH 6.0 and eluted with 250 mM, 500 mM, 1000 mM, and 1500 mM NaCl in the same buffer, in a stepwise manner. The absorbance at 280 mm of the effluent is continuously monitored. Fractions are collected and further analyzed by SDS-PAGE.
Fractions containing the [0244] E. faecalis polypeptide are then pooled and mixed with 4 volumes of water. The diluted sample is then loaded onto a previously prepared set of tandem columns of strong anion (Poros HQ-50, Perseptive Biosystems) and weak anion (Poros CM-20, Perseptive Biosystems) exchange resins. The columns are equilibrated with 40 mM sodium acetate, pH 6.0. Both columns are washed with 40 mM sodium acetate, pH 6.0, 200 mM NaCl. The CM-20 column is then eluted using a 10 column volume linear gradient ranging from 0.2 M NaCl, 50 mM sodium acetate, pH 6.0 to 1.0 M NaCl, 50 mM sodium acetate, pH 6.5. Fractions are collected under constant A₂₈₀monitoring of the effluent. Fractions containing the E. faecalis polypeptide (determined, for instance, by 16% SDS-PAGE) are then pooled.
The resultant [0245] E. faecalis polypeptide exhibits greater than 95% purity after the above refolding and purification steps. No major contaminant bands are observed from Commassie blue stained 16% SDS-PAGE gel when 5 μg of purified protein is loaded. The purified protein is also tested for endotoxin/LPS contamination, and typically the LPS content is less than 0.1 ng/ml according to LAL assays.

Example 2(d)

Cloning and Expression of [0246] E. Faecalis in Other Bacteria
[0247] E. faecalis polypeptides can also be produced in: E. faecalis using the methods of S. Skinner et al., (1988) Mol. Microbiol. 2:289-297 or J. I. Moreno (1996) Protein Expr. Purif. 8(3):332-340; Lactobacillus using the methods of C. Rush et al., 1997 Appl. Microbiol. Biotechnol. 47(5):537-542; or in Bacillus suibtilis using the methods Chang et al., U.S. Pat. No. 4,952,508.

Example 3

Cloning and Expression in COS Cells [0248]
A [0249] E. faecalis expression plasmid is made by cloning a portion of the DNA encoding a E. faecalis polypeptide into the expression vector pDNAI/Amp or pDNAIII (which can be obtained from Invitrogen, Inc.). The expression vector pDNAI/amp contains: (1) an E. coli origin of replication effective for propagation in E. coli and other prokaryotic cells; (2) an ampicillin resistance gene for selection of plasmid-containing prokaryotic cells; (3) an SV40 origin of replication for propagation in eukaryotic cells; (4) a CMV promoter, a polylinker, an SV40 intron; (5) several codons encoding a hemagglutinin fragment (i.e., an “HA” tag to facilitate purification) followed by a termination codon and polyadenylation signal arranged so that a DNA can be conveniently placed under expression control of the CMV promoter and operably linked to the SV40 intron and the polyadenylation signal by means of restriction sites in the polylinker. The HA tag corresponds to an epitope derived from the influenza hemagglutinin protein described by Wilson et al. 1984 Cell 37:767. The fusion of the HA tag to the target protein allows easy detection and recovery of the recombinant protein with an antibody that recognizes the HA epitope. pDNAIII contains, in addition, the selectable neomycin marker.
A DNA fragment encoding a [0250] E. faecalis polypeptide is cloned into the polylinker region of the vector so that recombinant protein expression is directed by the CMV promoter. The plasmid construction strategy is as follows. The DNA from a E. faecalis genomic DNA prep is amplified using primers that contain convenient restriction sites, much as described above for construction of vectors for expression of E. faecalis in E. coli. The 5′ primer contains a Kozak sequence, an AUG start codon, and nucleotides of the 5′ coding region of the E. faecalis polypeptide. The 3′ primer, contains nucleotides complementary to the 3′ coding sequence of the E. faecalis DNA. a stop codon, and a convenient restriction site.
The PCR amplified DNA fragment and the vector, pDNAI/Amp, are digested with appropriate restriction enzymes and then ligated. The ligation mixture is transformed into an appropriate [0251] E. coli strain such as SURE™ (Stratagene Cloning Systems, La Jolla, Calif. 92037), and the transformed culture is plated on ampicillin media plates which then are incubated to allow growth of ampicillin resistant colonies. Plasmid DNA is isolated from resistant colonies and examined by restriction analysis or other means for the presence of the fragment encoding the E. faecalis polypeptide
For expression of a recombinant [0252] E. faecalis polypeptide, COS cells are transfected with an expression vector, as described above, using DEAE-dextran, as described, for instance, by Sambrook et al. (supra). Cells are incubated under conditions for expression of E. faecalis by the vector.
Expression of the [0253] E. faecalis-HA fusion protein is detected by radiolabeling and immunoprecipitation, using methods described in, for example Harlow et al., supra. To this end, two days after transfection, the cells are labeled by incubation in media containing ³⁵S-cysteine for 8 hours. The cells and the media are collected, and the cells are washed and the lysed with detergent-containing RIPA buffer: 150 mM NaCl, 1% NP-40, 0.1% SDS, 1% NP-40, 0.5% DOC, 50 mM TRIS, pH 7.5, as described by Wilson et al. (supra ). Proteins are precipitated from the cell lysate and from the culture media using an HA-specific monoclonal antibody. The precipitated proteins then are analyzed by SDS-PAGE and autoradiography. An expression product of the expected size is seen in the cell lysate, which is not seen in negative controls.

Example 4

Cloning and Expression in CHO Cells [0254]
The vector pC4 is used for the expression of [0255] E. faecalis polypeptide in this example. Plasmid pC4 is a derivative of the plasmid pSV2-dhfr (ATCC Accession No. 37146). The plasmid contains the mouse DHFR gene under control of the SV40 early promoter. Chinese hamster ovary cells or other cells lacking dihydrofolate activity that are transfected with these plasmids can be selected by growing the cells in a selective medium (alpha minus MEM, Life Technologies) supplemented with the chemotherapeutic agent methotrexate. The amplification of the DHFR genes in cells resistant to methotrexate (MTX) has been well documented. See, e.g., Alt et al., 1978, J. Biol. Chem. 253:1357-1370; Hamlin et al., 1990, Biochem. et Biophys. Acta, 1097:107-143; Page et al., 1991, Biotechnology 9:64-68. Cells grown in increasing concentrations of MTX develop resistance to the drug by overproducing the target enzyme, DHFR, as a result of amplification of the DHFR gene. If a second gene is linked to the DHFR gene, it is usually co-amplified and over-expressed. It is known in the art that this approach may be used to develop cell lines carrying more than 1,000 copies of the amplified gene(s). Subsequently, when the methotrexate is withdrawn, cell lines are obtained which contain the amplified gene integrated into one or more chromosome(s) of the host cell.
Plasmid pC4 contains the strong promoter of the long terminal repeat (LTR) of the Rouse Sarcoma Virus, for expressing a polypeptide of interest, Cullen, et al. (1985) Mol. Cell. Biol. 5:438-447; plus a fragment isolated from the enhancer of the immediate early gene of human cytomegalovirus (CMV), Boshart, et al., 1985, Cell 41:521-530. Downstream of the promoter are the following single restriction enzyme cleavage sites that allow the integration of the genes: Bam HI, Xba I, and Asp 718. Behind these cloning sites the plasmid contains the 3′ intron and polyadenylation site of the rat preproinsulin gene. Other high efficiency promoters can also be used for the expression, e.g., the human β-actin promoter, the SV40 early or late promoters or the long terminal repeats from other retroviruses, e.g., HIV and HTLVI. Clontech's Tet-Off and Tet-On gene expression systems and similar systems can be used to express the [0256] E. faecalis polypeptide in a regulated way in mammalian cells (Gossen et al., 1992, Proc. Natl. Acad. Sci. USA 89:5547-5551. For the polyadenylation of the mRNA other signals, e.g., from the human growth hormone or globin genes can be used as well. Stable cell lines carrying a gene of interest integrated into the chromosomes can also be selected upon co-transfection with a selectable marker such as gpt, G418 or hygromycin. It is advantageous to use more than one selectable marker in the beginning, e.g., G418 plus methotrexate.
The plasmid pC4 is digested with the restriction enzymes and then dephosphorylated using calf intestinal phosphates by procedures known in the art. The vector is then isolated from a 1% agarose gel. The DNA sequence encoding the [0257] E. faecalis polypeptide is amplified using PCR oligonucleotide primers corresponding to the 5′ and 3′ sequences of the desired portion of the gene. A 5′ primer containing a restriction site, a Kozak sequence, an AUG start codon, and nucleotides of the 5′ coding region of the E. faecalis polypeptide is synthesized and used. A 3′ primer, containing a restriction site, stop codon, and nucleotides complementary to the 3′ coding sequence of the E. faecalis polypeptides is synthesized and used. The amplified fragment is digested with the restriction endonucleases and then purified again on a 1% agarose gel. The isolated fragment and the dephosphorylated vector are then ligated with T4 DNA ligase. E. coli HB101 or XL-1 Blue cells are then transformed and bacteria are identified that contain the fragment inserted into plasmid pC4 using, for instance, restriction enzyme analysis.
Chinese hamster ovary cells lacking an active DHFR gene are used for transfection. Five μg of the expression plasmid pC4 is cotransfected with 0.5 μg of the plasmid pSVneo using a lipid-mediated transfection agent such as Lipofectin™ or LipofectAMINE™ (LifeTechnologies Gaithersburg, MD). The plasmid pSV2-neo contains a dominant selectable marker, the neo gene from Tn5 encoding an enzyme that confers resistance to a group of antibiotics including G418. The cells are seeded in alpha minus MEM supplemented with 1 mg/ml G418. After 2 days, the cells are trypsinized and seeded in hybridoma cloning plates (Greiner, Germany) in alpha minus MEM supplemented with 10, 25, or 50 ng/ml of methotrexate plus 1 mg/ml G418. After about 10-14 days single clones are trypsinized and then seeded in 6-well petri dishes or 10 ml flasks using different concentrations of methotrexate (50 nM, 100 nM, 200 nM, 400 nM, 800 nM). Clones growing at the highest concentrations of methotrexate are then transferred to new 6-well plates containing even higher concentrations of methotrexate (1 μM, 2 μM, 5 μM, 10 mM, 20 mM). The same procedure is repeated until clones are obtained which grow at a concentration of 100-200 μM. Expression of the desired gene product is analyzed, for instance, by SDS-PAGE and Western blot or by reversed phase HPLC analysis. [0258]

Example 5

Quantitative Murine Soft Tissue Infection Model for [0259] E. Faecalis
Compositions of the present invention, including polypeptides and peptides, are assayed for their ability to function as vaccines or to enhance/stimulate an immune response to a bacterial species (e.g., [0260] E. faecalis) using the following quantitative murine soft tissue infection model. Mice (e.g., NIH Swiss female mice, approximately 7 weeks old) are first treated with a biologically protective effective amount, or immune enhancing/stimulating effective amount of a composition of the present invention using methods known in the art, such as those discussed above. See,e.g., Harlow et al., ANTIBODIES: A LABORATORY MANUAL, (Cold Spring Harbor Laboratory Press, 2nd ed. 1988). An example of an appropriate starting dose is 20 μg per animal.
The desired bacterial species used to challenge the mice, such as [0261] E. faecalis, is grown as an overnight culture. The culture is diluted to a concentration of 5×10⁸cfu/ml, in an appropriate media, mixed well, serially diluted, and titered. The desired doses are further diliuted 1:2 with sterilized Cytodex 3 microcarrier beads preswollen in sterile PBS (3 g/100 ml). Mice are anesthetize briefly until docile, but still mobile and injected with 0.2 ml of the Cytodex 3 bead/bacterial mixture into each animal subcutaneously in the inguinal region. After four days, counting the day of injection as day one, mice are sacrificed and the contents of the abscess is excised and placed in a 15 ml conical tube containing 1.0 ml of sterile PBS. The contents of the abscess is then enzymatically treated and plated as follows.
The abscess is first disrupted by vortexing with sterilized glass beads placed in the tubes. 3.Omls of prepared enzyme mixture (1.0 ml Collagenase D (4.0 mg/ml), 1.0 ml Trypsin (6.0 mg/ml) and 8.0 mls PBS) is then added to each tube followed by a 20 min. incubation at 37 C. The solution is then centrifuged and the supernatant drawn off. 0.5 ml dH20 is then added and the tubes are vortexed and then incubated for 10 min. at room temperature. 0.5 ml media is then added and samples are serially diluted and plated onto agar plates, and grown overnight at 37 C. Plates with distinct and separate colonies are then counted, compared to positive and negative control samples, and quantified. The method can be used to identify composition and determine appropriate and effective doses for humans and other animals by comparing the effective doses of compositions of the present invention with compositions known in the art to be effective in both mice and humans. Doses for the effective treatment of humans and other animals, using compositions of the present invention, are extrapolated using the data from the above experiments of mice. It is appreciated that further studies in humans and other animals may be needed to determine the most effective doses using methods of clinical practice known in the art. [0262]

Example 6

Murine Systemic Neutropenic Model for [0263] E. Faecalis Infection
Compositions of the present invention, including polypeptides and peptides, are assayed for their ability to function as vaccines or to enhance/stimulate an immune response to a bacterial species (e.g., [0264] E. faecalis) using the following qualitative murine systemic neutropenic model. Mice (e.g., NIH Swiss female mice, approximately 7 weeks old) are first treated with a biologically protective effective amount, or immune enhancing/stimulating effective amount of a composition of the present invention using methods known in the art, such as those discussed above. See, e.g., Harlow et al., ANTIBODIES: A LABORATORY MANUAL, (Cold Spring Harbor Laboratory Press, 2nd ed. 1988). An example of an appropriate starting dose is 20 μg per animal. Mice are then injected with 250-300 mg/kg cyclophosphamide intraperitonially. Counting the day of C.P. injection as day one, the mice are left untreated for 5 days to begin recovery of PMNL'S.
The desired bacterial species used to challenge the mice, such as [0265] E. faecalis, is grown as an overnight culture. The culture is diluted to a concentration of 5×10⁸cfu/ml, in an appropriate media, mixed well, serially diluted, and titered. The desired doses are further diliuted 1:2 in 4% Brewer's yeast in media. Mice are injected with the bacteria/brewer's yeast challenge intraperitonially. The Brewer's yeast solution alone is used as a control. The mice are then monitered twice daily for the first week following challenge, and once a day for the next week to ascertain morbidity and mortality. Mice remaining at the end of the experiment are sacrificed. The method can be used to identify compositions and determine appropriate and effective doses for humans and other animals by comparing the effective doses of compositions of the present invention with compositions known in the art to be effective in both mice and humans. Doses for the effective treatment of humans and other animals, using compositions of the present invention, are extrapolated using the data from the above experiments of mice. It is appreciated that further studies in humans and other animals may be needed to determine the most effective doses using methods of clinical practice known in the art.
The disclosure of all publications (including patents, patent applications, journal articles, laboratory manuals, books, or other documents) cited herein are hereby incorporated by reference in their entireties. [0266]

The present invention is not to be limited in scope by the specific embodiments described herein, which are intended as single illustrations of individual aspects of the invention. Functionally equivalent methods and components are within the scope of the invention, in addition to those shown and described herein and will become apparant to those skilled in the art from the foregoing description and accompanying drawings. Such modifications are intended to fall within the scope of the appended claims.

TABLE 1


Nucleotide and Amino Acid Seqeuences of E. faecalis Genes.

EF001-1 (SEQ ID NO:1)

TGAAAGAATA TTGCCAGAAC GTGGCGAGCA AATTGTTTTA TAAATTTTTT TAAGGGAGAG

AAAAAAATGA AGTTCAAAAC TCTAGCAACA ACAGTGTTAG CAACCGCAGC TATTTTCGCA

TTGGGGGCTT GTGGTAACGG TAATGGGGCC AAAGAATCAA ACGATATTGT GAAAGAAGTG

AAGGAAGATA CGACAATCAC TTTCTCGCAT GCAATGAATG GGGTTCAAGA AGAAGCGTTA

ACAAAATTAA CGAAAGACTT CATGAAAGAA AATCCAAAAA TTAAACTGGA ATTACAAAAT

CAATCTGCTT ACCCTGATTT ACAAGCCAAA ATCAATTCGA CTTTAACTTC ACCAAAAGAT

TTACCAACAA TTACGCAAGC GTACCCAGGC TGGTTATGGA ATGCTGCACA AGATGAAATG

TTAGTGGACT TAAAACCATA TATGGATGAT GACACAATCG GCTGGAAAGA TGCAGAGCCA

ATTCGTGAAG TATTGTTAGA CGGCGCCAAA ATCGACGGCA AACAATACGG CATTCCATTT

AATAAATCGA CAGAAATGTT ATTCTATAAT GCTGATTTGT TGAAAGAATA TGGTGTTGAA

GTACCGAAAA CATTAGAGGA ATTAAAAGAA GCTTCTAAAA CAATTTACGA AAAATCCAAC

AAAGAAGTCG TTGGTGCTGG TTTTGACTCG TTAAATAACT ATTACGCAAT TGGAATGAAA

AACAAAGGCG TTGATTTTAA TAAAGACTTA GATTTAACAA GCAAAGATTC ACAAGAAGTC

GTGGACTATT ACCGTGATGG TATCGAAGCA GGTTACTTCC GCACAGCTGG TTCAGATAAA

TATTTATCTG GCCCATTTGC AAACAAAAAG GTAGCAATGT TTGTCGGTAG TATTGCTGGT

GCTGGTTTTG TTCAAAAAGA TGCTGAAGCT GGTGGCTATG AATACGGTGT TGCACCACGT

CCTGAAAAAA TCAACTTACA ACAAGGAACA GATATTTATA TGTTCGATAG TGCTACGCCA

GAACAACGGA CAGCGGCATT TGAATTCATG AAATTCTTAG CTACTCCTGA TTCACAATTG

TACTGGGCAC AACAAACAGG TTATATGCCA ATTTTAGAAT CTGTTTTACA CAGTGATGAG

TACAAAAATT CTAAGACAAC CAAAGTACCT GCACAACTTG AAAACGCAGT AAAAGATTTA

TTCGCTATCC CAGTAGAAGA AAATGCTGAT TCAGCCTATA ATGAAATGCG GACAATTATG

GAAAGTATTT TTGCTTCATC AAATAAAGAC ACGAGAAAAT TATTGAAAGA TGCAACATCA

CAATTTGAAC AAGCATGGAA CCAATAA

EF001-2 (SEQ ID NO:2)

MKFKTLATT VLATAAIFAL GACGNGNGAK ESNDIVKEVK

EDTTITFWHA MNGVQEEALT KLTKDFMKEN PKIKVELQNQ SAYPDLQAKI NSTLTSPKDL

PTITQAYPGW LWNAAQDEML VDLKPYMDDD TIGWKDAEPI REVLLDGAKI DGKQYGIPFN

KSTEMLFYNA DLLKEYGVEV PKTLEELKEA SKTIYEKSNK EVVGAGFDSL NNYYAIGMKN

KGVDFNKDLD LTSKDSQEVV DYYRDGIEAG YFRTAGSDKY LSGPFANKKV AMFVGSIAGA

GFVQKDAEAG GYEYGVAPRP EKINLQQGTD IYMFDSATPE QRTAAFEFMK FLATPDSQLY

WAQQTGYMPI LESVLHSDEY KNSKTTKVPA QLENAVKDLF AIPVEENADS AYNEMRTIME

SIFASSNKDT RKLLKDATSQ FEQAWNQ

EF001-3 (SEQ ID NO:3)

TT GTGGTAACGG TAATGGGGCC AAAGAATCAA ACGATATTGT GAAAGAAGTG

AAGGAAGATA CGACAATCAC TTTCTGGCAT GCAATGAATG GGGTTCAAGA AGAAGCGTTA

ACAAAATTAA CGAAAGACTT CATGAAAGAA AATCCAAAAA TTAAAGTGGA ATTACAAAAT

CAATCTGCTT ACCCTGATTT ACAAGCCAAA ATCAATTCGA CTTTAACTTC ACCAAAAGAT

TTACCAACAA TTACGCAAGC GTACCCAGGC TGGTTATGGA ATGCTGCACA AGATGAAATG

TTAGTGGACT TAAAACCATA TATGGATGAT GACACAATCG GCTGGAAAGA TGCAGAGCCA

ATTCGTGAAG TATTGTTAGA CGGCGCCAAA ATCGACGGCA AACAATACGG CATTCCATTT

AATAAATCGA CAGAAATGTT ATTCTATAAT GCTGATTTGT TGAAAGAATA TGGTGTTGAA

GTACCGAAAA CATTAGAGGA ATTAAAAGAA GCTTCTAAAA CAATTTACGA AAAATCCAAC

AAAGAAGTCG TTGGTGCTGG TTTTGACTCG TTAAATAACT ATTACGCAAT TGGAATGAAA

AACAAAGGCG TTGATTTTAA TAAAGACTTA GATTTAACAA GCAAAGATTC ACAAGAAGTC

GTGGACTATT ACCGTGATGG TATCGAAGCA GGTTACTTCC GCACAGCTGG TTCAGATAAA

TATTTATCTG GCCCATTTGC AAACAAAAAG GTAGCAATGT TTGTCGGTAG TATTGCTGGT

GCTGGTTTTG TTCAAAAAGA TGCTGAAGCT GGTGGCTATG AATACGGTGT TGCACCACGT

CCTGAAAAAA TCAACTTACA ACAAGGAACA GATATTTATA TGTTCGATAG TGCTACGCCA

GAACAACGGA CAGCGGCATT TGAATTCATG AAATTCTTAG CTACTCCTGA TTCACAATTG

TACTGGGCAC AACAAACAGG TTATATGCCA ATTTTAGAAT CTGTTTTACA CAGTGATGAG

TACAAAAATT CTAAGACAAC CAAAGTACCT GCACAACTTG AAAACGCAGT AAAAGATTTA

TTCGCTATCC CAGTAGAAGA AAATGCTGAT TCAGCCTATA ATGAAATGCG GACAATTATG

GAAAGTATTT TTGCTTCATC AAATAAAGAC ACGAGAAAAT TATTGAAAGA TGCAACATCA

CAATTTGAAC AAGCATGGAA CCAA

EF001-4 (SEQ ID NO:4)

CGNGNGAK ESNDTVKEVK

EDTTITFWHA MNGVQEEALT KLTKDFMKEN PKIKVELQNQ SAYPDLQAKI NSTLTSPKDL

PTITQAYPGW LWNAAQDEML VDLKPYMDDD TIGWKDAEPI REVLLDGAKI DGKQYGIPFN

KSTEMLFYNA DLLKEYGVEV PKTLEELKEA SKTTYEKSNK EVVGAGFDSL NNYYALGMKN

KGVDFNKDLD LTSKDSQEVV DYYRDGTEAG YFRTAGSDKY LSGPFANKKV AMFVGSIAGA

GPVQKDAEAG GYEYGVAPRP EKINLQQGTD IYMFDSATPE QRTAAFEFMK FLATPDSQLY

WAQQTGYNPI LESVLHSDEY KNSKTTKVPA QLENAVKDLF AIPVEENADS AYNEMRTIME

SIFASSNKDT RKLLKDATSQ FEQAWNQ

EF002-1 (SEQ ID NO:5)

TAAATAGCGG AGGTAGTACA AATGAAATTT TGGAAAAAAG GCTTAACAGC GGCAGCGCTG

TTAGCAGTGG CGGCAGTAAC TTTAACAGCA TGTCGTGGTT CAAGTGAAAA GAAAGCAACT

GAAAAGAGTG AAGATGGCAA AACAAAATTA ACAGTAACTA CTTGGAATTA TGACACGACC

CCAGAATTTG AGAAATTATT CAGAGCTTTT GAAGCGGAAA ATCCTGATAT CACTATTGAA

CCGGTGGACA TTGCTTCAGA TGATTATGAC ACAAAAGTAA CAACGATGCT TTCATCAGGA

GATACGACGG ATATTTTAAC CATGAAAAAC TTACTTTCAT ATTCTAATTA CGCGCTACGC

AATCAATTGG TGGATTTAAC CGATCACGTT AAAGATTTAG ATATCGAACC TGCCAAAGCA

AGTTACGAGA TGTATGAAAT CGATGGTAAA ACCTATGCTC AGCCTTACCG TACAGATTTC

TGGGTATTGT ATTACAATAA AM,AATGTTT GATGAAGCCG GAATTGCCTA TCCCGATAAC

TTAACTTGGG ATGAATATGA AGCGTTAGCG AAAAAATTAT CTAAACCAGA AGAACAAGTA

TATCGTGCCT ATCAACATAC TTGGCGCTCA ACCGTTCAAG CGATTGCTGC TGCTCAAAAC

AATGCCAATT TGATTGAACC AAAATACAAT TATATGGAAA CTTATTATGA TCGCGCATTG

AGAATGCAAA AAGATCAATC ACAAATGGAT TTTGGAACAG CAAAATCAAC AAAAGTAACG

TATCAATCAC AATTTGAAAA TTCAAAAGCG GCGATGATGT ACATGGGTAG CTGGTACATG

GGGACTTTAT TAACAAACAT TGATGATGGC AAAACAAATG TCGAATGGGG GATTGCCGAA

ATACCACAAC AAGAAAAAGG CAAAGCAACT ACCTTTGGCT CACCGACAAG TTTTGCAATT

AATAAAAACA GTAAAAAACA AAAAGCTGCT CAAAAATTCT TAGACTTTGC TTCAGGTAAA

GAAGGTGCAA AACTTTTAGC AGAAGTAGGG GTGGTTCCTT CTTATAAAAC AGATGAAATT

GATAAAATCT ACTTTGCAAG AAAAGGAATG CCTTCAGACG AGTCTCACAA AAACCCTTTA

ACCCAGATAC AATTAATTTA G

EF002-2 (SEQ ID NO:6)

MKFW KKGLTAAALL AVAAVTLTAC GGSSEKKATE KSEDGKTKLT VTTWNYDTTP

EFEKLFRAFE AENPDITIEP VDIASDDYDT KVTTMLSSGD TTDILTMKNL LSYSNYALRN

QLVDLTDHVK DLDIEPAKAS YEMYEIDGKT YAQPYRTDFW VLYYNKKMFD EAGIAYPDNL

TWDEYEALAK KLSKPEEQVY GAYQHTWRST VQAIAAAQNN ANLIEPKYNY METYYDRALR

MQKDQSQMDF GTAKSTKVTY QSQFENSKAA MMYMGSWYMG TLLTNIDDCK TNVEWGIAEI

PQQEKGKATT FGSPTSFAIN KNSKKQKAAQ KFLDFASGKE GAKLLAEVGV VPSYKTDEID

KIYFARKGMP SDESHKKPLT QIQLT

EF002-3 (SEQ ID NO:7)

A TGTGGTGGTT CAAGTGAAAA GAAAGCAACT

GAAAAGAGTG AAGATGGCAA AACAAAATTA ACAGTAACTA CTTGGAATTA TGACACCACC

CCAGAATTTG AGAAATTATT CAGAGCTTTT GAAGCGGAAA ATCCTGATAT CACTATTGAA

CCGGTGGACA TTGCTTCAGA TGATTATGAC ACAAAAGTAA CAACGATGCT TTCATCAGGA

GATACGACGG ATATTTTAAC CATGAAAAAC TTACTTTCAT ATTCTAATTA CGCGCTACGC

AATCAATTGG TGGATTTAAC CGATCACGTT AAAGATTTAG ATATCGAACC TGCCAAAGCA

AGTTACGAGA TGTATGAAAT CGATGGTAAA ACCTATGCTC AGCCTTACCG TACAGATTTC

TGGGTATTGT ATTACAATAA AAAAATGTTT GATGAAGCCG GAATTGCCTA TCCCGATAAC

TTAACTTGGG ATGAATATGA AGCGTTAGCG AAAAAATTAT CTAAACCAGA AGAACAAGTA

TATGGTGCCT ATCAACATAC TTGGCGCTCA ACCGTTCAAG CGATTGCTGC TGCTCAAAAC

AATGCCAATT TGATTGAACC AAAATACAAT TATATGGAAA CTTATTATGA TCGCGCATTG

AGAATGCAAA AAGATCAATC ACAAATGCAT TTTGGAACAG CAAAATCAAC AAAAGTAACG

TATCAATCAC AATTTGAAAA TTCAAAAGCG GCGATGATGT ACATGGGTAG CTGGTACATG

GGGACTTTAT TAACAAACAT TGATGATGGC AAAACAAATG TCGAATGGGG GATTGCCGAA

ATACCACAAC AAGAAAAAGG CAAAGCAACT ACCTTTGGCT CACCGACAAG TTTTGCAATT

AATAAAAACA GTAAAAAACA AAAAGCTGCT CAAAAATTCT TAGACTTTGC TTCAGGTAAA

CAAGGTGCAA AACTTTTAGC AGAAGTAGGG GTGGTTCCTT CTTATAAAAC AGATGAAATT

GATAAAATCT ACTTTGCAAG AAAAGGAATG CCTTCAGACG AGTCTCACAA AAAGCCTTTA

ACCCAGATAC AATTAATT

EF002-4 (SEQ ID NO:8)

C GGSSEKKATE KSEDGKTKLT VTTWNYDTTP

EFEKLFRAFE AENPDITIEP VDIASDDYDT KVTTMLSSGD TTDILTMKNL LSYSNYALRN

QLVDLTDHVK DLDIEPAKAS YEMYEIDGKT YAQPYRTDFW VLYYNKKMFD EAGIAYPDNL

TWDEYEALAK KLSKPEEQVY GAYQHTWRST VQAIAAAQNN ANLIEPKYNY METYYDRALR

MQKDQSQMDF GTAKSTKVTY QSQFENSKAA MMYMGSWYMG TLLTNIDDGK TNVEWGIAEI

PQQEKGKATT FGSPTSFAIN KNSKKQKAAQ KFLDFASGKE GAKLLAEVGV VPSYKTDEID

KTYFARKGMP SDESHKKPLT QIQLI

EF003-1 (SEQ ID NO:9)

TAGGAGGACA AAAGAATGAA GAAGTTTTAT TTAGCNACAT TCGCTGTTAT TGCAACAGTT

ATTTTAGCTG CCTGTGGGGG AAATAAACAA GCAGACCAGA AAGAAGACAA GGAGATTACC

GTTGCCGTGC AATTGGAATC TTCAAAAGAT ATCTTGGAGA TTGCCAAGAA AGAAGCTGAG

AAAAAAGGGT ACAAAATTAA CATTATGGAA GTGAGCGACA ATGTTGCCTA CAACGATGCC

GTGCAACATG ACGAAGCGGA TGCTAATTTT GCGCAACATC AACCCTTCAT GGAAATGTTT

AACAAAGAGA AAAAAGCTGA TTTAGTGGCT GTGCAACCGA TTTATTATTT TGCTGGTGGT

TTCTATTCAA AAGAATACCA AGATGCGAAA GATTTACCTG AAAATGCCAA AGTGGGGATT

CCTAGCGATC CAACCAATGA AGGTCGTGCT TTAGCAATTT TAAATGCAAA CGGCGTGATT

AAATTAAAAG AAGGTGTCGG CTTTAACGGC ACGGTGGCAG ATGTCGTGGA AAATCCTAAA

AACATCACTT TTGAAAGCAT TGATTTACTG AATTTAGCTA AAGCCTATGA TGAAAAAGAC

ATCGCTATGG TGTTCTGCTA CCCAGCCTAC TTAGAACCTG CTGGTTTAAC AACGAAAGAT

GCGATCTTGT TAGAAGATAA AGAAGCAAGT AAACATTACG CATTGCAAGT TGTGACACGC

AAAGGCGAAA AACATAGCGA AAAAATCAAG GTTTTAAAAG AAGCGATGAC AACAAAAGAA

GTTGCTGAAT ACATCAAGAA AAATTCTAAA GGCGCCAATA TTCCTGCGTT TTAA

EF003-2 (SEQ ID NO:10)

MKKFYL ATFAVIATVI LAACGGNKQA DQKEDKEITV AVQLESSKDI LEIAKKEAEK

KGYKINIMEV SDNVAYNDAV QHDEADANFA QHQPFMEMFN KEKKADLVAV QPIYYFAGGF

YSKEYQDAKD LPENAKVCIP SDPTNEGRAL AILNANGVIK LKEGVGFNGT VADVVENPKN

ITFESTDLLN LAKAYDEKUT AMVFCYPAYL EPAGLTTKDA ILLEDKEASK HYALQVVTRK

GEKDSEKTKV LKEAMTTKEV AEYTKKNSKG ANIPAF

EF003-3 (SEQ ID NO:11)

CTGTGGGGG AAATAAACAA GCAGACCAGA AAGAAGACAA GGAGATTACC

GTTGCCGTGC AATTGGAATC TTCAAAAGAT ATCTTGGAGA TTGCCAAGAA AGAAGCTGAG

AAAAAAGGGT ACAAAATTAA CATTATGGAA GTGAGCGACA ATCTTGCCTA CAACGATGCC

GTGCAACATG ACGAAGCGGA TGCTAATTTT GCGCAACATC AACCCTTCAT GGAAATGTTT

AACAAAGAGA AAAAAGCTGA TTTAGTGGCT GTGCAACCGA TTTATTATTT TGCTGGTGGT

TTCTATTCAA AAGAATACCA AGATGCGAAA GATTTACCTG AAAATGCCAA AGTGGGGATT

CCTAGCGATC CAACCAATGA AGGTCGTGCT TTAGCAATTT TAAATGCAAA CGGCGTGATT

AAATTAAAAG AAGGTGTCGG CTTTAACGGC ACGGTGGCAG ATGTCGTGGA AAATCCTAAA

AACATCACTT TTGAAAGCAT TGATTTACTG AATTTAGCTA AAGCCTATGA TGAAAAAGAC

ATCGCTATGG TGTTCTGCTA CCCAGCCTAC TTAGAACCTG CTGGTTTAAC AACGAAAGAT

GCGATCTTGT TAGAAGATAA AGAAGCAAGT AAACATTACG CATTGCAAGT TGTGACACGC

AAAGGCGAAA AAGATAGCGA AAAAATCAAG GTTTTAAAAG AAGCGATGAC AACAAAAGAA

GTTGCTGAAT ACATCAAGAA AAATTCTAAA GGCGCCAATA TTCCTGCGTT T

EF003-4 (SEQ ID NO:12)

CGGNKQA DQKEDKEITV AVQLESSKDI LEIAKKEAEK

KGYKINTMEV SDNVAYNDAV QHDEADANFA QHQPFNEMFN KEKKADLVAV QPIYYFAGGF

YSKEYQDAKD LPENAKVGIP SDPTNEGRAL AILNANGVIK LKEGVGFNGT VADVVENPKN

ITFESIDLLN LAKAYDEKDI ANVECYPAYL EPAGLTTKDA ILLEDKEASK HYALQVVTRK

GEKDSEKIKV LKEANTTKEV AEYIKKNSKG ANIPAF

EF004-1 (SEQ ID NO:13)

TAAATCGAAA GAAGGATGAT AGAAATGAAA AAAATGATTA AATTTGCAGG CATTGCTCTT

ATTTTTGCAG CTCTTCTCTC TGCCTGTAGC AACGCAAAAA ATAATACACA AAAGAAAGCC

GAAACTGCTG CCCAGTCAAG CACTATTGAA GCTTCAGACA GTAACGAAAA CGAGCCTAAT

ACAGAAAACA TAACCCAAGC AGTTAAACAG TTAGAAGAAA AATTTAACTC TGACGAGAAA

TTAGTAAAAA TAGATGTTAA AAATAATGTT AAAGATGACA CATCAGATAA CCCTCACGCT

GTCATTACGG TTAAGGTAAT TAATGATGAA GCAAAAAAAA ATATGGAAGA AATGCAGACT

GCGATAGATT CCAACTCAGG TACAGAGGCA CAAAAGACTG CCATATACGG AATTCAATTA

AATGTTGAAG AAGTAGCCAA AACATTAGAA AATGATAACG ATGTTATTTC TTTCATCACA

CCTTACACGA ATGGGAACGA CAGAACCATA GCAAAATCAA CTAAAAATGA AAATATTATT

CCGTTAGTAA AATAA

EF004-2 (SEQ ID NO:14)

MKK MIKFAGIALI FAALLSACSN AKNNTQKKAE TAAQSSTIEA SDSNENEPNT

ENITQAVKQL EEKFNSDEKL VKIDVKNNVK DDTSDNPHAV ITVKVINDEA KKNMEEMQTA

IDSNSGTEAQ KTAIYGIQLN VEEVAKTLEN DNDVISFITP YTNGNDRTIA KSTKNENIIP

LVK

EF004-3 (SEQ ID NO:15)

CTGTAGC AACGCAAAAA ATAATACACA AAAGAAAGCC

GAAACTGCTG CCCAGTCAAG CACTATTGAA GCTTCAGACA GTAACGAAAA CGAGCCTAAT

ACAGAAAACA TAACCCAAGC ACTTAAACAG TTAGAAGAAA AATTTAACTC TGACGAGAAA

TTAGTAAAAA TAGATGTTAA AAATAATGTT AAAGATGACA CATCAGATAA CCCTCACGCT

GTCATTACGG TTAAGGTAAT TAATGATGAA GCAAAAAAAA ATATGGAAGA AATGCAGACT

GCGATAGATT CCAACTCAGG TACAGAGOCA CAAAAGACTG CCATATACGG AATTCAATTA

AATGTTGAAG AAGTAGCCAA AACATTAGAA AATGATAACG ATGTTATTTC TTTCATCACA

CCTTACACGA ATGGGAACGA CAGAACCATA GCAAAATCAA CTAAAAATGA AAATATTATT

CCGTTAGTAA AA

EF004-4 (SEQ ID NO:16)

CSN AKNNTQKKAE TAAQSSTIEA SDSNENEPNT

ENITQAVKQL EEKFNSDEKL VKIDVKNNVK DDTSDNPHAV ITVKVINDEA KKNMEEMQTA

IDSNSGTEAQ KTAIYGIQLN VEEVAKTLEN DNDVISFITP YTNGNDRTIA KSTKNENIIP

LVK

EF005-1 (SEQ ID NO:17)

TAAAAAATGA AAAAACGATT GACGATTGTG GGGATGCTTT TTCTGGCCAT TTTAGTAATG

GTTGGTTGTG GTAAAAATCA GCAAGCAACG ACAAAAGAAA AAGAGACAAA ACCTGAAGAA

CTAACTCTTT ACATTGTGCG CCACGGAAAA ACCATGTTAA ATACGACGGA CCGCGTACAA

GGATGGTCAG ATGCGGTCCT AACACCAGAA GGTGAAAAAG TTGTGACAGC AACTGGGATT

GGACTGAAAG ATGTTGCCTT TCAAAATGCA TATAGTAGTG ATAGTGGCCG CGCCTTGCAA

ACTGCTCAAC TTATTTTAGA TCAAAATAAA GCAGGCAAAG ACCTTGAAGT CGTGCGTGAC

CCAGATTTAC GTGAATTTAA TTTTGGTAGC TATGAAGGGG ATTTAAATAA GACAATGTGG

CAGGATATTG CTGATGATCA AGGTGTTTCC TTAGAAGAAT TTATGAAAAA CATGACTCCT

GAATCCTTTG CCAATAGTGT AGCTAAACTG GATCAACAGC GCGAGGAAAG CAAGAATAAC

TGGCCTGCAG AAGACTATGC TACAATTACT AAACGTTTGA AAAAAGGCTT AGATAAAATT

GTTGCCACAG AATCAGCCAA TTCTGGGAAT GGCAATGTTT TAGTGGTCTC TCATGGCTTG

AGTATTTCAG CGTTGTTAGC AACTTTATTT GATGATTTTA AAGTCCCAGA AGGCGGTTTG

AAGAATGCTA GTGTCACAAC AATTCATTAC AAAAATGGCG AATATACTTT GGATAAAGTC

AATCATGTCA GCTACTTAGA AGCAGGCGAA AAAGAATCAA AATAA

EF005-2 (SEQ ID NO:18)

MKKRLTIVG MLFLAILVMV GCGKNQQATT KEKETKPEEL TLYIVRHGKT MLNTTDRVQG

WSDAVLTPEG EKVVTATGTC LKDVAFQNAY SSDSGRALQT AQLILDQNKA GKDLEVVRDP

DLREFNFGSY EGDLNKTMWQ DIADDQGVSL EEFMKNMTPE SFANSVAKLD QQREESKNNW

PAEDYATITK RLKKGLDKIV ATESANSGNG NVLVVSHGLS ISALLATLED DFKVPEGGLK

NASVTTIHYK NGEYTLDKVN DVSYLEAGEK ESK

EF005-3 (SEQ ID NO:19)

TTGTG GTAAAAATCA GCAAGCAACG ACAAAAGAAA AAGAGACAAA ACCTGAAGAA

CTAACTCTTT ACATTGTGCG CCACGGAAAA ACCATGTTAA ATACGACGGA CCGCGTACAA

GGATGGTCAG ATGCGGTCCT AACACCAGAA GGTGAAAAAG TTGTGACAGC AACTGGGATT

GGACTGAAAG ATGTTGCCTT TCAAAATCCA TATAGTAGTG ATAGTGGCCG CGCCTTGCAA

ACTGCTCAAC TTATTTTAGA TCAAAATAAA GCAGGCAAAG ACCTTGAAGT CGTGCGTGAC

CCAGATTTAC GTGAATTTAA TTTTGGTAGC TATGAAGGGG ATTTAAATAA GACAATGTCG

CAGGATATTG CTGATGATCA AGGTGTTTCC TTAGAAGAAT TTATGAAAAA CATGACTCCT

GAATCCTTTG CCAATAGTGT AGCTAAACTG GATCAACAGC GCGAGGAAAG CAAGAATAAC

TGGCCTGCAG AAGACTATGC TACAATTACT AAACGTTTGA AAAAAGGCTT AGATAAAATT

GTTCCCACAG AATCAGCCAA TTCTCGGAAT GGCAATGTTT TAGTGGTCTC TCATGGCTTG

AGTATTTCAG CGTTGTTAGC AACTTTATTT GATGATTTTA AAGTCCCAGA AGGCGGTTTG

AAGAATGCTA GTGTCACAAC AATTCATTAC AAAAATGGCG AATATACTTT GGATAAAGTC

AATGATGTCA GCTACTTAGA AGCAGGCGAA AAAGAATCAA AA

EF005-4 (SEQ ID NO:20)

CGKNQQATT KEKETKPEEL TLYIVRHGKT MLNTTDRVQG

WSDAVLTPEG EKVVTATGIG LKDVAFQNAY SSDSCRALQT AQLILDQNKA GKDLEVVRDP

DLREFNFGSY EGDLNKTMWQ DIADDQGVSL EEFMKNMTPE SFANSVAKLD QQREESKNNW

PAEDYATITK RLKKGLDKTV ATESANSGNG NVLVVSHGLS ISALLATLED DFKVPEGGLK

NASVTTIHYK NGEYTLDKVN DVSYLEAGEK ESK

EF006-1 (SEQ ID NO:21)

TAAACGATAA ATGGAGGGAA TAAGATGAAA AAACGTACAT TATCGTCAGT AATTACTGTA

GCAGTACCTG TCTTAGTTTT AGGGGCTTGC GGCAATAAAA AGAGTGATGA CTCCGTCTTG

AAAGTTGGAG CTTCACCAGT TCCACATGCA GAGATTTTAG AACATGTAAA ACCTTTATTA

GAAAAAGAAG GCGTAAAATT AGAAGTGACG ACTTATACAG ATTACGTCCT ACCTAACAAG

GCGTTGGAAA GTGGCGATAT CGATGCCAAC TATTTCCAAC ATGTGCCGTT CTTTAATGAA

GCGGTTAAAG AAAATGATTA TGACTTTGTG AATGCAGGTG CGATTCATTT AGAACCAGTT

GGGCTTTACT CGAAAAAATA CAAATCGTTA CAAGAAATTC CTGATGGTTC AACGATTTAC

GTTACCTCTT CCGTTTCAGA TTGGCCACGC GTATTAACTA TCTTAGAAGA TGCTGGTTTA

ATCACGCTGA AAGAAGGGGT AGACCGGACA ACTGCTACTT TCGATGATAT TGATAAAAAT

ACTAAAAAGT TGAAATTCAA TCATGAAAGT GATCCAGCAA TCATGACCAC TCTTTATGAC

AXTGAAGAAC GGGCTGCGGT TTTAATTAAC TCAAACTTTG CCGTGGATCA AGGATTAAAT

CCGAAAAAAG ATGCGATTGC CTTAGAAAAA GAAAGTTCAC CTTATGCCAA TATTATTGCG

GTTCGTAAAG AAGACGAAAA CAACGAAAAT GTAAAAAAAT TAGTCAAAGT GTTACCTAGC

AAAGAAGTCC AAGATTGGAT TACGAAAAAA TGGAACGGCG CTATTGTTCC AGTCAATGAA

TAA

EF006-2 (SEQ ID NO:22)

MKK RTLWSVITVA VAVLVLGACG NKKSDDSVLK VGASPVPHAE ILEHVKPLLE

KEGVKLEVTT YTDYVLPNKA LESGDIDANY FQHVPFFNEA VKENDYDFVN AGAIHLEPVG

LYSKKYKSLQ EIPDGSTIYV SSSVSDWPRV LTILEDAGLI TLKEGVDRTT ATFDDIDKNT

KKLKFNHESD PAIMTTLYDN EEGAAVLINS NFAVDQGLNP KKDAIALEKE SSPYANIIAV

RKEDENNENV KKLVKVLRSK EVQDWITKKW NGAIVPVNE

EF006-3 (SEQ ID NO:23)

TTGC GGCAATAAAA AGAGTGATGA CTCGCTCTTG

AAAGTTGGAG CTTCACCAGT TCCACATGCA GAGATTTTAG AACATGTAAA ACCTTTATTA

GAAAAAGAAG GCGTAAAATT AGAAGTGACG ACTTATACAG ATTACGTGCT ACCTAACAAG

GCGTTGGAAA GTGGCGATAT CGATGCCAAC TATTTCCAAC ATGTGCCGTT CTTTAATGAA

GCGGTTAAAG AAAATGATTA TGACTTTGTG AATGCAGGTG CGATTCATTT AGAACCAGTT

GGGCTTTACT CGAAAAAATA CAAATCGTTA CAAGAAATTC CTGATGGTTC AACGATTTAC

GTTAGCTCTT CCGTTTCAGA TTGCCCACGC CTATTAACTA TCTTAGAAGA TGCTCGTTTA

ATCACGCTGA AAGAAGGGGT AGACCGGACA ACTGCTACTT TCGATGATAT TGATAAAAAT

ACTAAAAAGT TGAAATTCAA TCATGAAAGT GATCCAGCAA TCATGACCAC TCTTTATGAC

AATGAAGAAG CGGCTGCGGT TTTAATTAAC TCAAACTTTG CCGTGGATCA AGGATTAAAT

CCGAAAAAAG ATGCGATTGC CTTAGAAAAA GAAAGTTCAC CTTATGCCAA TATTATTGCG

GTTCGTAAAG AAGACGAAAA CAACGAAAAT GTAAAAAAAT TAGTCAAAGT GTTACGTAGC

AAAGAAGTCC AAGATTGGAT TACGAAAAAA TGGAACGGCC CTATTGTTCC AGTCAATGAA

EF006-4 (SEQ ID NO:24)

CC NKKSDDSVLK VGASPVPHAE ILEHVKPLLE

KEGVKLEVTT YTDYVLPNKA LESGDIDANY FQHVPFFNEA VKENDYDFVN AGAIHLEPVG

LYSKKYKSLQ EIPDCSTIYV SSSVSDWPRV LTILEDAGLI TLKEGVDRTT ATFDDIDKNT

KKLKFNHESD PAIMTTLYDN EEGAAVLTNS NFAVDQGLNP KKDAIALEKE SSPYANIIAV

RKEDENNENV KKLVKVLRSK EVQDWTTKKW NGAIVPVNE

EF008-1 (SEQ ID NO:25)

TAAACCCTGA GAAAGAAATC GAGOAATCAA CCAATGAAAA AATTTAGTTT ATTTTTTTTA

ACACTTTTAG CAGGGTTAAC GTTAGCTGCT TCCGCGAATC AAGCCGCTGA AAAGAAAGAA

AAATTAGCAA TTGTGACAAC GAACTCGATC CTATCTGATT TAGTCAAAAA TGTTGCCCAA

GACAAAATTG AGCTGCATAG TATTGTGCCA ATTGGGACAG ACCCTCACGA ATATGAACCG

TTACCAGAAG ACATTGCGAA AGCTTCTGAA GCCGACATTT TATTCTTTAA CGGCTTGAAC

TTAGAAACAG GCGGAAATGG CTGGTTTAAC AAATTAATGA AAACGGCCAA AAAAGTTGAG

AATAAAGATT ACTTTTCTAC AAGCAAAAAT GTTACGCCAC AATATTTAAC AAGTGCCGGT

CAACAACAAA CAGAAGATCC ACATGCTTGG TTAGACATTG AAAATGGCAT TAAATATGTA

GAAAACATTC GTGACGTGTT AGTAGAAAAA CATCCAAAAA ATAAAGATTT CTATACAGAA

AACGCGAAAA ATTATACCGA AAAACTTAGC AAACTACATG AGGAAGCCAA AGCTAAATTT

GCTCATATTC CTGATGATAA AAAATTATTA GTTACAAGTG AAGGTGCCTT TAAATATTTC

TCCAAAGCTT ATGATTTAAA TGCCGCTTAT ATTTGGGAAA TTAACACAGA AAGTCAACGN

ACACCTCAAC AAATGACCAC GATTATTGAT ACCATTAAGA AATCAAAAGC ACCTGTGTTA

TTTGTTGAAA CCAGTGTCGA TAAACGTAGT ATGGAACGCG TCTCAAAAGA ACTGAAACGA

CCAATTTACG ATACACTTTT CACAGACTCT CTTGCCAAAG AAGGAACAGA AGGCCATACG

TACTACACCA TGATGAACTG GAATTTAACA AAAATCCATG ATGGCTTAAT GAGTAAATAA

EF008-2 (SEQ ID NO:26)

MKKFSLFFLT LLAGLTLAAC CNQAAEKKEK LAIVTTNSIL SDLVKNVGQD

KIELHSIVPI GTDPHEYEPL PEDIAKASSA DILFFNGLNL ETGCNGWFNK LMKTAKKVEN

KDYFSTSKNV TPQYLTSAGQ EQTEDPHAWL DIENGIKYVE NIRDVLVEKD PKNKDFYTEN

AKNYTEKLSK LHEEAKAKFA DIPDDKKLLV TSEGAFKYFS KAYDLNAAYI WEINTESQGT

PEQMTTIIDT IKKSKAPVLF VETSVDKRSM ERVSKEVKRP IYDTLFTDSL AKEGTEGDTY

YSMMNWNLTK IHDGLMSK

EF008-3 (SEQ ID NO:27)

T TGCGGGAATC AAGCCGCTGA AAAGAAAGAA

AAATTAGCAA TTGTGACAAC GAACTCGATC CTATCTGATT TACTGAAAAA TGTTGGGCAA

GACAAAATTG AGCTGCATAG TATTGTGCCA ATTGGGACAG ACCCTCACGA ATATGAACCC

TTACCAGAAG ACATTGCGAA AGCTTCTGAA GCGGACATTT TATTCTTTAA CGGCTTGAAC

TTAGAAACAG CCGGAAATCG CTGGTTTAAC AAATTAATGA AAACGGCCAA AAAAGTTGAG

AATAAAGATT ACTTTTCTAC AAGCAAAAAT CTTACGCCAC AATATTTAAC AAGTGCCGGT

CAAGAACAAA CAGAAGATCC ACATGCTTGG TTAGACATTG AAAATCGCAT TAAATATCTA

CAAAACATTC GTGACGTGTT AGTAGAAAAA GATCCAAAAA ATAAAGATTT CTATACAGAA

AACGCCAAAA ATTATACCGA AAAACTTAGC AAACTACATG AGGAAGCCAA AGCTAAATTT

GCTGATATTC CTGATCATAA AAAATTATTA GTTACAAGTG AAGGTGCCTT TAAATATTTC

TCCAAAGCTT ATGATTTAAA TGCCGCTTAT ATTTGGGAAA TTAACACAGA AAGTCAAGGN

ACACCTGAAC AAATGACCAC GATTATTGAT ACCATTAAGA AATCAAAAGC ACCTGTGTTA

TTTGTTGAAA CCAGTGTCGA TAAACGTAGT ATGGAACGGG TCTCAAAAGA AGTGAAACGA

CCAATTTACG ATACACTTTT CACAGACTCT CTTGCCAAAG AAGGAACAGA AGGCGATACG

TACTACAGCA TGATGAACTG GAATTTAACA AAAATCCATG ATGGCTTAAT GAGTAAA

EF008-4 (SEQ ID NO:28)

c GNQAAEKKEK LAIVTTNSIL SDLVKNVGQD

KIELHSIVPI GTDPHEYEPL PEDIAKASSA DILFFNGLNL ETOGNOWENK LMKTAKKVEN

KDYESTSKNV TPQYLTSAGQ EQTEDPHAWL DIENGIKYVE NIRDVLVEKD PKNKDFYTEN

AKNYTEKLSK LHEEAKAKFA DIPDDKKLLV TSECAFKYFS KAYDLNAAYI WEINTESQOT

PEQMTTIIDT IKKSKAPVLF VETSVDKRSM ERVSKEVKRP IYDTLFTDSL AKEGTEGDTY

YSMMNWNLTK IHDGLMSK

EF009-1 (SEQ ID NO:29)

TGACAAATGA AAAAATTTAG TAAATTAATT GGACTTATTG GGCTATTAGC TTTTACGATT

GCAGGTTGTG CATCGGGGTC TGTGAAGGAT ACTAAGACAG AAACCGTTAA ACTAGGGGTT

GTAGGAACAA AAAATGATGA ATGGGAATCG GTCAAAGACC GTTTGAAAAA GAAAAATATT

GATTTACAAT TGGTAGAATT TACAGACTAT ACGCAACCAA ACGCAGCATT AGCAGAAAAA

GAAATTGATT TAAATGCCTT TCAGCATCAA ATCTTTTTAG ACAATTACAA TAAAGAGCAT

GGAACGAAAT TAGTATCAAT TGGCAATACA GTCAATGCAC CATTGGGAAT TTACGCTAAT

AAATTGAAAG ATATCACGAA AATTAAAGAC GGCGGAGAAA TTGCTATTCC TAATGACCCA

ACGAATGGCG GGCGGGCGTT AATTTTATTA CAAACTGCAG GACTGATAAA ACTAGATOCT

GCGAAACAGC AACTACCGAC TGTCAGTGAT ATTACTGAAA ATAAACGCCA ATTGAAAATA

ACTGAATTAG ATOCTACOCA AACAGCGCGC GCTTTACAAG ATGTCGATGC TTCAGTGATT

AATAGCGGCA TGGCTGTCGA TGCTGGGTAT ACACCAGATA AAGATGCTAT TTTCTTAGAA

CCTGTAAACG AAAAAGCGAA ACCTTATGTG AACATTGTCG TGGCCCGAGA AGAAGATCAA

GAGAATAAAC TTTATCAAAA AGTTGTAGAA GAATATCAAC AAGAAGAAAC GAAAAAGGTC

ATTGCAGAAA CATCAAAAGG CGCCAATGTT CCAGCCTGCG AAACATTTCG TAAAAAATAA

EF009-2 (SEQ ID NO:30)

MKKFSKLIG LIGVLAFTIA GCASGSVKDT KTETVKLGVV GTKNDEWESV KDRLKKKNID

LQLVEFTDYT QPNAALAEKE IDLNAFQHQI FLDNYNKEHG TKLVSIGNTV NAPLGIYANK

LKDTTKIKDG GEIAIPNDPT NGGEALILLQ TAGLIKVDPA KQQLPTVSDI TENKRQLKIT

ELDATQTARA LQDVDASVIN SGMAVDAGYT PDKDAIELEP VNEKAKPYVN IVVAREEDQE

NKLYQKVVEE YQQEETKKVI AETSKGANVP AWETFGKK

EF009-3 (SEQ ID NO:31)

TTGTG CATCGGGGTC TGTGAAGGAT ACTAAGACAG AAACCGTTAA ACTAGGGGTT

GTAGGAACAA AAAATGATGA ATGGGAATCG GTCAAAGACC GTTTGAAAAA GAAAAATATT

GATTTACAAT TGGTAGAATT TACAGACTAT ACGCAACCAA ACGCAGCATT AGCAGAAAAA

GAAATTGATT TAAATGCCTT TCAGCATCAA ATCTTTTTAG ACAATTACAA TAAAGAGCAT

GGAACGAAAT TAGTATCAAT TGGCAATACA GTCAATGCAC CATTGGGAAT TTACGCTAAT

AAATTGAAAG ATATCACGAA AATTAAAGAC GGCGGAGAAA TTGCTATTCC TAATGACCCA

ACGAATGGCG GGCGGGCGTT AATTTTATTA CAAACTGCAG GACTGATAAA AGTAGATCCT

GCGAAACAGC AACTACCGAC TGTCAGTGAT ATTACTGAAA ATAAACGCCA ATTGAAAATA

ACTGAATTAG ATGCTACGCA AACAGCGCGC GCTTTACAAG ATGTCGATGC TTCAGTGATT

AATAGCGGCA TGGCTGTCGA TGCTGGGTAT ACACCAGATA AAGATGCTAT TTTCTTAGAA

CCTGTAAACG AAAAAGCGAA ACCTTATGTG AACATTGTCG TGGCCCGAGA AGAAGATCAA

GAGAATAAAC TTTATCAAAA AGTTGTAGAA GAATATCAAC AAGAAGAAAC GAAAAAGGTC

ATTGCAGAAA CATCAAAAGC CCCCAATGTT CCAGCCTGGG AAACATTTGG TAAAAAA

EF009-4 (SEQ ID NO:32)

CASGSVKDT KTETVKLOVV GTKNDEWESV KDRLKKKNID

LQLVEFTDYT QPNAALAEKE IDLNAFQHQI FLDNYNKEHG TKLVSIGNTV NAPLGIYANK

LKDITKTKDG GEIAIPNDPT NGGRALILLQ TAGLIKVDPA KQQLPTVSDI TENKRQLKIT

ELDATQTAEA LQDVDASVIN SGMAVDAGYT PDKDAIFLEP VNEKAKPYVN IVVAREEDQE

NKLYQKVVEE YQQEETKKVT AETSKGANVP AWETFGKK

EF010-1 (SEQ ID NO:33)

TGAAAGAATA AAATTGTACA GGAGGAAATA AGGAATGAAA AAATGGCAAA AAGGATTAGC

CGTAGCTGGC GCACAGCTTT AGCTGTAGGA CTAAGCGCGT GCGGTAAATC TTCAAAAGAT

GCAGCGTCAA AAGGTGATGA TAGTACACCA ACCTTATTAA TGTATCGTGT TGGGGACAAA

CCAGATAATT ATGACCAATT AATCGATAAT GCGAATAAAA TTATCGAGAA AAAAATTGGG

GCAAAATTAA AAATGGAATT TGTTGGTTGG GGCGATTGGG ACCAAAAAAT GTCAACAATC

GTTCCTTCTG GTGAAAGCTA TGATATTTCA TTAGCACAAA ATTATGCAAC GAATGCACAA

AAAGGCGCCT ATCCTGATTT AACTGATTTA GCACCTAAAT ATGCCAAAGA AGCCTATGAT

CAATTGCCAG ATAACTATAT TAAAGGAAAT ACGATTAATG GAAAACTGTA TGCGTTCCCA

ATTTTAGGTA ACTCTTACGC TCAACAAGTT TTAACTTTTA ATAAAGAATA TGTCGATAAA

TACAATTTAG ATATTAGTAA AGTCGATGGT AGTTATGAAA GTGCAACGGA AGTTCTAAAA

GAATTCCNTA AAAANGANCC AAATATTGCT GCTTTTGCTA TCGGCCAAAC ATTCTTTGCA

ACAGGTAATT ATGACTTCCC TATTGGTAAC CAATATCCAT TTGCAGTAAA AACAACTGAT

ACTGGCTCAC CAAAAATTAT TAACCAATAT GCCGACAAAG ACATGATTAA TAACTTAAAA

GTCTTGCATC AATGGTATAA AGATGGCTTG ATTCCAACAC ATGCTGCTAC AAGTACAACA

CCATATGACT TAAATACCAA TACTTGGTTT ATGCGTCAAG AAACACAAGG ACCTATGGAT

TATGGTCATA CAATCTTAAC ACAACCTGCT CGCAAACCAC TTGTTTCTCG TCCACTAACA

GAACCATTAA AAACAACACC TCAAGCGCAA ATCGCTAACT ATGTTGTTGC AAACACGTCT

AAAAACAAAG AAAAATCTGT TGAATTGTTA CGTTTATTAA ACAGCAATCC AGAATTGTTA

AACGGACTTG TTTATGGTGA ACAAGGCAAA CAATATGAAA AACTTGGCGA TGATCGTGTG

AAATTGTTGA AAGATTACAC ACCAACAACT CATTTGAGTG CTTGGAACAC AGGAAACAAC

TTAATCATTT CGCCAGAAGA ATCTGTCACT GAAGAAATGG TTAAAGAACG TGATAAGAGC

ATCGAAGAAG CAAAAGATTC ACCAATTCTT GGTTTTACTT TTGTAAATGA TAAAGTGAAA

ACTGAAATCA CTAACGTTCC TACAGTTATG AACCGTTACG CAGCAACCTT AAATACAGGA

ACTGTTCATC CAGAAGAAAC ACTTCCAAAA TTAATGGATG ACCTAAAAAC AGCTGGCTGG

CATAAAGTTC AAAAAGAAAT GCAAACACAA TTAGACGAAT ATATCCAATC TCAAAAATAA

EF010-2 (SEQ ID NO:34)

MAKRISR SWRTALAVGL SACGKSSKDA ASKGDDSTPT LLMYRVGDKP

DNYDQLIDNA NKIIEKKIGA KLKMEFVGWG DWDQKNSTIV ASGESYDISL AQNYATNAQK

GAYADLTDLA PKYAKEAYDQ LPDNYIKGNT INGKLYAFPI LCNSYGQQVL TFNKEYVDKY

NLDISKVDGS YESATEVLKE FXKXXPNIAA FAIGQTFFAT GNYDFPIGNQ YPFAVKTTDT

GSPKIINQYA DKDMINNLKV LHQWYKDGLI PTDAATSTTP YDLNTNTWFM RQETQGPMDY

GDTILTQAAG KPLVSRPLTE PLKTTAQAQM ANYVVANTSK NKEKSVELLG LLNSNPELLN

GLVYCEEGKQ YEKVGDDRVK LLKDYTPTTH LSAWNTGNNL IIWPEESVTE EMVKERDKSI

EEAKDSPILG FTFVNDKVKT EITNVATVHN RYAASLNTGT VDPEETLPKL MDDLKTAGWD

KVQKEMQTQL DEYIQSQK

EF010-3 (SEQ ID NO:35)

GT GCGGTAAATC TTCAAAAGAT

GCAGCGTCAA AAGGTGATGA TAGTACACCA ACGTTATTAA TGTATCGTGT TGGGGACAAA

CCAGATAATT ATGACCAATT AATCGATAAT GCGAATAAAA TTATCGAGAA AAAAATTGGG

GCAAAATTAA AAATGGAATT TCTTGGTTGG GGCGATTGGG ACCAAAAAAT GTCAACAATC

GTTGCTTCTG GTGAAAGCTA TGATATTTCA TTAGCACAAA ATTATGCAAC GAATGCACAA

AAAGGCGCCT ATGCTGATTT AACTGATTTA GCACCTAAAT ATGCCAAAGA AGCCTATGAT

CAATTGCCAG ATAACTATAT TAAAGGAAAT ACGATTAATG GAAAACTGTA TGCGTTCCCA

ATTTTAGGTA ACTCTTACGG TCAACAAGTT TTAACTTTTA ATAAAGAATA TGTCGATAAA

TACAATTTAG ATATTAGTAA AGTCGATGGT AGTTATGAAA GTGCAACGGA AGTTCTAAAA

GAATTCCNTA AAAANGANCC AAATATTGCT GCTTTTGCTA TCGGCCAAAC ATTCTTTGCA

ACAGGTAATT ATGACTTCCC TATTGGTAAC CAATATCCAT TTGCAGTAAA AACAACTGAT

ACTGGCTCAC CAAAAATTAT TAACCAATAT GCCGACAAAC ACATGATTAA TAACTTAAAA

GTCTTGCATC AATGGTATAA AGATGGCTTG ATTCCAACAG ATGCTGCTAC AAGTACAACA

CCATATGACT TAAATACCAA TACTTGGTTT ATGCGTCAAG AAACACAAGG ACCTATGGAT

TATGGTGATA CAATCTTAAC ACAAGCTGCT GGCAAACCAC TTGTTTCTCG TCCACTAACA

GAACCATTAA AAACAACAGC TCAAGCGCAA ATGGCTAACT ATGTTGTTGC AAACACGTCT

AAAAACAAAG AAAAATCTGT TGAATTGTTA GGTTTATTAA ACAGCAATCC AGAATTCTTA

AACGGACTTG TTTATGGTGA AGAAGGCAAA CAATATGAAA AAGTTGGCGA TGATCGTGTG

AAATTGTTGA AAGATTACAC ACCAACAACT CATTTGAGTG CTTGGAACAC AGGAAACAAC

TTAATCATTT GGCCAGAAGA ATCTGTCACT GAAGAAATGG TTAAAGAACG TGATAAGAGC

ATCGAAGAAG CAAAAGATTC ACCAATTCTT GGTTTTACTT TTGTAAATGA TAAAGTGAAA

ACTGAAATCA CTAACGTTGC TACAGTTATG AACCGTTACG CAGCAAGCTT AAATACAGGA

ACTGTTGATC CAGAAGAAAC ACTTCCAAAA TTAATGGATG ACCTAAAAAC AGCTGGCTGG

GATAAAGTTC AAAAAGAAAT GCAAACACAA TTAGACGAAT ATATCCAATC TCAAAAA

EF010-4 (SEQ ID NO:36)

CGKSSKDA ASKGDDSTPT LLMYRVGDKP

DNYDQLIDNA NKIIEKKIGA KLKMEFVGWG DWDQKMSTIV ASGESYDISL AQNYATNAQK

GAYADLTDLA PKYAKEAYDQ LPDNYIKGNT INGKLYAFPI LGNSYGQQVL TFNKEYVDKY

NLDISKVDGS YESATEVLKE FXKXXPNIAA FAIGQTFFAT GNYDFPIGNQ YPFAVKTTDT

GSPKIINQYA DKDMINNLKV LHQWYKDGLI PTDAATSTTP YDLNTNTWFM RQETQGPMDY

GDTILTQAAG KPLVSRPLTE PLKTTAQAQM ANYVVANTSK NKEKSVELLG LLNSNPELLN

GLVYGEEGKQ YEKVGDDRVK LLKDYTPTTH LSAWNTGNNL IIWPEESVTE EMVKERDKSI

EEAKDSPILG FTFVNDKVKT EITNVATVMN RYAASLNTGT VDPEETLPKL MDDLKTAGWD

KVQKEMQTQL DEYIQSQK

EF011-1 (SEQ ID NO:37)

TAACGTTTTT GGAGGAAAAG AATGAAAAAG AAATTTTTAG CAATGATGGC AGTTTCAATG

ATGGGACTGT TAATGTTAAG TGCTTGTCAA ACAAATAAAA AAACAGCAGA TTCTGCAACA

ACAGAAACAA CAGCTAAAAC GGAAGTCACA GTCAAAGACA CCAATGGTCA ATTAACCGTT

CCCAAAAATC CTAAGAAAGT CGTTGTTTTT GATAATGGTT CCTTGGATAC AATGGATGCA

CTAGGTGTCG GTGACCGCGT GGTAGGTGCG CCAACTAAAA ATATCCCTGC GTATTTGAAA

AAATACCAAA AAGTTCAATC AGCAGGCGGC ATTAAAGAAC CAGATTTAGA AAAAATCAAT

CAACTAAAAC CAGACTTAAT TATTATTTCT GGTCGTCAAC AAGATTATCA AGAACAATTA

AAAGCCATTG CGCCAACCAT TTACTTAGCT GTAGATGCCA AAAATCCTTG GGCATCAACG

AAACAAAATA TCGAAACGTT AGGCACTATT TTTGATAAAG AAGAGGTAGC TAAAGAAAAA

ATAACTGCCT TAGAAAAAGA AATTGCTGAC GTGAAAAAAC AAGCAGAAGC TAGCGCGAAT

AATGCGCTTG TTGTGTTAGT TAACGAAGGA CAACTTTCCG CTTACGGAAA AGGCTCTCGT

TTCGGTTTAA TTCATGATAC ATTTGGCTTC AAAGCAGCAG ACGATAAGAT TGAAGCTTCC

ACTCATGGGC AAAGTGTTTC TTACGAATAT GTTTTAGAAA AAAATCCTGG GATTCTCTTT

GTGGTAGATC GCACCAAAGC AATTGGTGGC GACGATTCAA AAGATAACGT CGCTGCAAAC

GAATTGATTC AAAAAACCGA TGCTGGTAAA AATGATAAAG TCATTATGCT TCAACCAGAT

GTTTGGTATC TAAGCGGTGG TGGATTAGAA TCAATGCATT TGATGATAGA AGATGTTAAA

AAAGGATTAG AGTAA

EF011-2 (SEQ ID NO:38)

MKKK FLANMAVSMM GLLMLSACQT NKKTADSATT ETTAKTEVTV KDTNGQLTVP

KNPKKVVVFD NGSLDTMDAL GVGDRVVGAP TKNIPAYLKK YQKVESAGGI KEPDLEKINQ

LKPDLIIISG RQQDYQEQLK AIAPTIYLAV DAKNPWASTK QNIETLGTIF DKEEVAKEKI

TGLEKEIADV KKQAEASANN ALVVLVNEGQ LSAYGKGSRF GLIHDTFGFK AADDKIEAST

HGQSVSYEYV LEKNPGILFV VDRTKAIGGD DSKDNVAANE LIQKTDAGKN DKVIMLQPDV

WYLSGGGLES MHLMIEDVKK GLE

EF011-3 (SEQ ID NO:39)

TTGTCAA ACAAATAAAA AAACAGCAGA TTCTGCAACA

ACAGAAACAA CAGCTAAAAC GGAAGTCACA GTCAAAGACA CCAATGGTCA ATTAACCGTT

CCCAAAAATC CTAAGAAAGT CGTTGTTTTT GATAATGGTT CCTTGGATAC AATGGATGCA

CTAGGTGTCG GTGACCGCGT GGTAGGTGCG CCAACTAAAA ATATCCCTGC GTATTTGAAA

AAATACCAAA AAGTTGAATC AGCACGCCGC ATTAAAGAAC CAGATTTAGA AAAAATCAAT

CAACTAAAAC CAGACTTAAT TATTATTTCT GGTCGTCAAC AAGATTATCA AGAACAATTA

AAAGCCATTG CGCCAACCAT TTACTTAGCT GTAGATGCCA AAAATCCTTG GGCATCAACG

AAACAAAATA TCGAAACGTT AGGCACTATT TTTGATAAAG AAGAGGTAGC TAAAGAAAAA

ATAACTGGCT TAGAAAAAGA AATTGCTGAC GTGAAAAAAC AAGCAGAAGC TAGCGCGAAT

AATGCGCTTG TTGTGTTAGT TAACGAAGGA CAACTTTCCG CTTACGGAAA AGGCTCTCGT

TTCGGTTTAA TTCATGATAC ATTTGGCTTC AAAGCAGCAG ACGATAAGAT TGAAGCTTCC

ACTCATGGGC AAAGTGTTTC TTACGAATAT GTTTTAGAAA AAAATCCTGG GATTCTCTTT

GTGGTAGATC GCACCAAAGC AATTGGTGGC GACGATTCAA AAGATAACGT CGCTGCAAAC

GAATTGATTC AAAAAACCGA TGCTGGTAAA AATGATAAAG TCATTATGCT TCAACCAGAT

GTTTGGTATC TAAGCGGTGG TGGATTAGAA TCAATGCATT TGATGATAGA AGATGTTAAA

AAAGGATTAG AG

EF011-4 (SEQ ID NO:40)

CQT NKKTADSATT ETTAKTEVTV KDTNGQLTVP

KNPKKVVVFD NGSLDTMDAL GVGDRVVGAP TKNIPAYLKK YQKVESAGGI KEPDLEKINQ

LKPDLIIISG RQQDYQEQLK AIAPTIYLAV DAKNPWASTK QNIETLGTIF DKEEVAKEKI

TGLEKEIADV KKQAEASANN ALVVLVNEGQ LSAYGKGSRF GLIHDTFGFK AADDKIEAST

HGQSVSYEYV LEKNPGILFV VDRTKAIGGD DSKDNVAANE LIQKTDAGKN DKVIMLQPDV

WYLSGGGLES MHLMIEDVKK GLE

EF012-1 (SEQ ID NO:41)

TGAGGGGGCA ACAACATGAA ATTGGGGAAA AAAGTAGTAG GTTTGATTGC AACAGGGTTT

CTTTTAGCCG CATGTGGCGG AACCAAAGAA GCGGCAGAGA AAGTAGATTC GGGAAATTTA

GCAGCTGAAC AAAAAATCAG TATTAGTTCA CCTGCACCAA TCTCAACATT GGATACAACA

CAAACAACAG ATAAAAATAC CTTTACAATG GCACAACATT TATTTGAAGG CCTTTATCGG

TTTGATGATG ATAGTGCCAC GGTGCCAGCT CTAGCTAAAG ATGTCAAGAT TAGTGACGAT

GGGCGCAAGT ACCACTTTAC CTTGCGGGAG GGGATTAAGT GGAGCAACGG CGAGCCAATC

ACGGCCCAAG ATTTTGTTTA TTCTTGGAAA AAACTGGTGA CACCAGCGAC GATTGGACCG

AATGCCTATT TACTAGACAG TGTTAAAAAT AGTTTTGAAA TACGCAACGG TGAAAAGTCA

GTCGATGAAT TAGGGATTTC AGCCCCGAAT GACAAAGAAT TCATTGTTGA ATTAAAACAG

GCCCAACCTT CCTTCTTAGC AGTCGTTTCG ATTGCTTGGT TAGCGCCACA AAATCAAAAA

TTTGTCGAAG CGCAAGGCAA AGATTACGCC TTGGATAGTG AACATTTACT TTATAGCGGG

CCATTTACGC TAGCCAATTG GGATGCGACT TCAGATACTT GGACATTGAA AAAAAATCCA

GAATACTATG ATGCGGATCA AGTGAAACTG GAAGAAGTTG CGGTTAGCAC AATCAAAGAA

GATAATACTG GGATTAACTT ATATCAAGTG AATGAACTAG ACTTAGTTCG CATTAACGGA

CAATATGTTC AACAATATCA AGATGATCCA GGCTATGTCA GTCATCCAGA TGTGGCCAAC

TACTTCTTAG ATTTCAACAA AAAAGAAGGA ACGCCATTAG CGAATGTTCA TTTACGAAAA

GCGATTGGCC AAGCAATTGA TAAAGAAGCC TTAACACAAA GTGTCTTAAA CGATGGGTCA

AAACCCCTTA ACGGATTGAT TCCAAGTAAA CTTTATGCGA ATCCAGAAAC GGATGAAGAT

TTCCGAGCTT ACAGTGGCGA ATATTTGAAA AATGACGTCA AAAAAGCTCA AGCTGAATGG

ACGAAAGCCC AAGCGGATGT CGGTAAAAAA GTGAAACTTT CATTGCTGGC GGCAGACACA

GATCAAGGAA AACGAATTGC TGAATATGTT CAAAGTCAGT TGCAAGAAAA TCTGCCAGGT

TTAGAAATTA CCATTTCATC GCAACCAAGT AATAATGTGA ACCAATCGCG ACGTGAAAAA

AATTATGAGT TGTCTCTTTC AGGATGGATT GCCGGCAGTA GTGAATTAGA CTCTTACTTT

AACTTATATG CAGGAGAATC AAGTTACAAT TACGGCAATT ATCATAATGC CAAATACGAC

CAATTGGTAG AAGAGGCACG AACGATTAAT GCCAATAATC CAGAGAAACA GTTTGCAGAA

TACAAAGAAG CGGAAGACAT CTTGTTGAAC CAAGATGCTG CCCAAGTACC GCTGTATCAA

AGTGCCTCAA ATTATCTAAT CAATCCTAAA TTGAAAGGCA TTAGTTATCA CTTGTATGGG

GATTATTTCC ACTTGCGCAA TGCCTATTTA ACAGAATGA

EF012-2 (SEQ ID NO:42)

MKLGKK WGLIATGFL LAACGGTKEA AEKVDSGNLA AEQKISISSP APISTLDTTQ

TTDKNTFTMA QHLFEGLYRF DDDSATVPAL AKDVKISDDG RKYHFTLREG IKWSNGEPIT

AQDFVYSWKK LVTPATIGPN AYLLDSVKNS FEIRNGEKSV DELGISAPND KEFIVELKQA

QPSFLAVVSI AWLAPQNQKF VEAQGKDYAL DSEHLLYSGP FTLANWDATS DTWTLKKNPE

YYDADQVKLE EVAVSTIKED NTGINLYQVN ELDLVRINGQ YVQQYQDDPG YVSHPDVANY

FLDFNKKEGT PLANVHLRKA IGQAIDKEAL TQSVLNDGSK PLNGLIPSKL YANPETDEDF

PAYSGEYLKN DVKKAQAEWT KAQADVGKKV KLSLLAADTD QGKRIAEYVQ SQLQENLPGL

EITISSQPSN NVNQSRREKN YELSLSGWIA GSSELDSYFN LYAGESSYNY GNYHNAKYDQ

LVEEARTINA NNPEKQFAEY KEAEDILLNQ DAAQVPLYQS ASNYLINPKL KGISYHLYGD

YFHLRNAYLT S

EF012-3 (SEQ ID NO:43)

ATGTGGCGG AACCAAAGAA GCGGCAGAGA AAGTAGATTC GGGAAATTTA

GCAGCTGAAC AAAAAATCAG TATTAGTTCA CCTGCACCAA TCTCAACATT GGATACAACA

CAAACAACAG ATAAAAATAC CTTTACAATG GCACAACATT TATTTGAAGG CCTTTATCGG

TTTGATGATG ATAGTGCCAC GGTGCCAGCT CTAGCTAAAG ATGTCAAGAT TAGTGACGAT

GGGCGCAAGT ACCACTTTAC CTTGCGGGAG GGGATTAAGT GGAGCAACGG CGAGCCAATC

ACCGCCCAAC ATTTTGTTTA TTCTTGGAAA AAACTGGTGA CACCAGCGAC GATTGGACCG

AATGCCTATT TACTAGACAG TGTTAAAAAT AGTTTTGAAA TACGCAACGG TGAAAAGTCA

GTCGATGAAT TAGGGATTTC AGCCCCGAAT GACAAAGAAT TCATTGTTGA ATTAAAACAG

GCCCAACCTT CCTTCTTAGC AGTCGTTTCG ATTGCTTGGT TAGCGCCACA AAATCAAAAA

TTTGTCGAAG CGCAAGGCAA AGATTACGCC TTGGATAGTG AACATTTACT TTATAGCGGG

CCATTTACGC TAGCCAATTG GGATGCGACT TCAGATACTT GGACATTGAA AAAAAATCCA

GAATACTATG ATGCGGATCA AGTGAAACTG GAAGAAGTTG CGGTTAGCAC AATCAAAGAA

GATAATACTG GGATTAACTT ATATCAAGTG AATGAACTAG ACTTAGTTCG CATTAACGGA

CAATATGTTC AACAATATCA AGATGATCCA GGCTATGTCA GTCATCCAGA TGTGGCCAAC

TACTTCTTAG ATTTCAACAA AAAAGAAGGA ACGCCATTAG CGAATGTTCA TTTACGAAAA

GCGATTGGCC AAGCAATTGA TAAAGAAGCC TTAACACAAA GTGTCTTAAA CGATGGGTCA

AAACCCCTTA ACGGATTGAT TCCAAGTAAA CTTTATGCGA ATCCAGAAAC CGATGAAGAT

TTCCGAGCTT ACAGTGGCGA ATATTTGAAA AATGACGTCA AAAAAGCTCA AGCTGAATGG

ACGAAAGCCC AAGCGGATGT CGGTAAAAAA GTGAAACTTT CATTGCTGGC GGCAGACACA

GATCAAGGAA AACGAATTGC TGAATATGTT CAAAGTCAGT TGCAAGAAAA TCTGCCAGGT

TTAGAAATTA CCATTTCATC GCAACCAAGT AATAATGTGA ACCAATCGCG ACGTGAAAkA

AATTATGAGT TGTCTCTTTC AGGATGGATT GCCGGCAGTA GTGAATTAGA CTCTTACTTT

AACTTATATG CAGGAGAATC AAGTTACAAT TACGGCAATT ATCATAATGC CAAATACGAC

CAATTGGTAG AAGAGGCACG AACGATTAAT GCCAATAATC CAGAGAAACA GTTTGCAGAA

TACAAAGAAG CGGAAGACAT CTTGTTGAAC CAAGATGCTG CCCAAGTACC GCTGTATCAA

AGTGCCTCAA ATTATCTAAT CAATCCTAAA TTGAAAGGCA TTAGTTATCA CTTGTATGGG

GATTATTTCC ACTTGCGCAA TGCCTATTTA ACAGAA

EF012-4 (SEQ ID NO:44)

CGGTKEA AEKVDSGNLA AEQKISISSP APISTLDTTQ

TTDKNTFTMA QHLFEGLYRF DDDSATVPAL AKDVKISDDG RKYHFTLREG IKWSNGEPIT

AQDFVYSWKK LVTPATIGPN AYLLDSVKNS FEIRNGEKSV DELGISAPND KEFTVELKQA

QPSFLAVVST AWLAPQNQKF VEAQGKDYAL DSEHLLYSGP FTLANWDATS DTWTLKKNPE

YYDADQVKLE EVAVSTIKED NTGINLYQVN ELDLVRINGQ YVQQYQDDPG YVSHPDVANY

FLDFNKKEGT PLANVHLRKA IGQAIDKEAL TQSVLNDGSK PLNGLIPSKL YANPETDEDF

RAYSGEYLKN DVKKAQAEWT KAQADVGKKV KLSLLAADTD QGKRIAEYVQ SQLQENLPGL

EITISSQPSN NVNQSRREKN YELSLSGWIA GSSELDSYFN LYAGESSYNY GNYHNAKYDQ

LVEEARTINA NNPEKQFAEY KEAEDILLNQ DAAQVPLYQS ASNYLINPKL KGISYHLYGD

YFHLRNAYLT E

EF013-1 (SEQ ID NO:45)

TAACGAAAAA TGAAAAAAAT TGCTTTGTTC AGTATGTTAA CGTTCAGTGT ATTGTCTTTA

AGTCTAGCAG GATGTGGAAA CAAAAAAACA GCAAGCACAA ATGATTCTAA GCCAAAGCAA

GAAACAAAGA AAGCCACGCA GAAATCCTCT AGCCAACAAG AAATGAAAAG TAGTCATTCG

TCTGTCACGG GTCAAAATTC TAATGTGACA GGGGAAAATC CGTCAGAAAA TGCCACGCAG

CCTTCTGCAG GAACTGATGA AACGAATGAA GTCCCTCAAA ACCAAGCACC TGATACAAAC

ATTACAATTA CCAATGTTGT TTTCAATCCT GAAAGAAATG AAATTAATGG TACTACATTA

CCTAATGCAA CCATTACAGC AACGGTAGTC GGTGATGCTT CTGCACAAGC AGGTGTTTTT

TATGCGGATG CCAATGGCAA TTTTACAGTA ATTAGTCCCA GAGCGGGAGC GACTACTCAA

TTAATCGCAA CCGTTGATCA ACGGAATAGT GCACCTGTCC AAATTGATAT TCCAAGTTCA

GGACAAGAAG CAGCGCTTTC TTTTAGCAAT ATTACGATTG ATCCGAAACA AGGGACAATT

TCTGGTAAAA CAGCACCGAA TGCAACTATT TTAGTGTCAC GTGCAGATGA TGCGCGGGTG

ATTTTAGCAA GTTTTACTGC GGATGCCCAA GGGAATTTCA CAGCCAGTAA TTTAGTTCCC

GGCACAAAAA ATCGCTTAGA TGTTACGTTA AATGGAGAAA TAGGGACACC TTACTTGTTT

GATTTACCAA ATTAA

EF013-2 (SEQ ID NO:46)

MKKIALFS MLTFSVLSLS LAGCGNKKTA STNDSKPKQE TKKATQKSSS QQEMKSSHSS

VTGQNSNVTG ENPSENATQP SAGTDETNEV PQNQAPDTNI TITNVVFNPE RNEINGTTLP

NATITATVVG DASAQAGVFY ADANGNFTVI SPRAGATTQL IATVDQRNSA PVQIDIPSSG

QEAALSFSNI TIDPKQGTIS GKTAPNATTL VSRADDARVI LASFTADAQG NFTASNLVPG

TKNRLDVTLN GEIGTPYLFD LPN

EF013-3 (SEQ ID NO:47)

ATGTGGAAA CAAAAAAACA GCAAGCACAA ATGATTCTAA GCCAAAGCAA

GAAACAAAGA AAGCCACGCA GAAATCCTCT AGCCAACAAG AAATGAAAAG TAGTCATTCG

TCTGTCACGG GTCAAAATTC TAATGTGACA GGGGAAAATC CGTCAGAAAA TGCCACGCAG

CCTTCTGCAG GAACTGATGA AACGAATGAA GTCCCTCAAA ACCAAGCACC TGATACAAAC

ATTACAATTA CCAATGTTGT TTTCAATCCT GAAAGAAATG AAATTAATGG TACTACATTA

CCTAATGCAA CCATTACAGC AACGGTAGTC GGTGATGCTT CTGCACAAGC AGGTGTTTTT

TATGCGGATG CCAATCGCAA TTTTACAGTA ATTAGTCCCA GAGCGGGAGC GACTACTCAA

TTAATCGCAA CCGTTGATCA ACGGAATAGT GCACCTGTCC AAATTGATAT TCCAAGTTCA

GGACAAGAAG CAGCGCTTTC TTTTAGCAAT ATTACGATTG ATCCGAAACA AGGGACAATT

TCTGGTAAAA CAGCACCGAA TGCAACTATT TTAGTGTCAC GTGCAGATGA TGCGCGGGTG

ATTTTAGCAA GTTTTACTGC GGATGCCCAA GGGAATTTCA CAGCCAGTAA TTTAGTTCCC

GGCACAAAAA ATCGCTTAGA TGTTACGTTA AATGGAGAAA TAGGGACACC TTACTTGTTT

GATTTACCAA AT

EF013-4 (SEQ ID NO:48)

CCNKKTA STNDSKPKQE TKKATQKSSS QQEMKSSHSS

VTGQNSNVTG ENPSENATQP SAGTDETNEV PQNQAPDTNI TITNVVFNPE RNEINGTTLP

NATITATVVG DASAQAGVFY ADANGNFTVI SPRAGATTQL IATVDQRNSA PVQIDIPSSG

QEAALSFSNI TIDPKQGTTS GKTAPNATIL VSRADDARVI LASFTADAQG NFTASNLVPG

TKNRLDVTLN GEIGTPYLFD LPN

EF014-1 (SEQ ID NO:49)

TGATGGTGGA GACTTTTTAA GAGAGAGGAA GTACAGCCAA TGAGTAGGAA GCGAAAAATC

ACCTTAATTA GTTTAGTCAT CATTTTGGTT TTTGTCACAG TCGGCTCAGC ATACTTTGCT

GTAGCGGGTA GCTATTTAAA GAAAACAATT GATAAAGGCT ATGTTCCCAT AAAAAATGAT

TATAATGAAG CCCAAAATAA AGATAGTCAA TCGTTTTTGA TTATGGGGCT AGACAATACA

ATTGAACGGA AATTAGGCAC AACTAGGACT GATGCTATGA TGGTGATTAC CGTGAATAAC

AAGACGAAGA AAATAACCTA TTTAAGTTTG CCACGGGATA GTTTTGTTCA AATTGATGCG

AAAAATTACC AAGGGATGCA GCGAATTGAA GCCGCCTATA CCTACGATGG ACCAACAGCT

TCTGTTAACA CAGTTGAGAA ATTATTGAAT ATTCCAATCA ATCATTACGT TGTGTTTAAC

TTTTTATCTT TTATTAAGTT AATTGATGCG GTTCGCGGCA TAGATGTCAA TGTCAAGCAG

GCGTTTGATG GTGTCACCAA AGACGGCCCA GGATCCATTC ATTTTGATGC AGGGAAACAG

CATTTAGATG GTACGAAAGC TTTATCTTAT GCCCGTGAAA GACATAGCGA TAACGATATT

ATGCGTGGAT TCCGACAACA AGAAATTATT CAAGCAGTTG AAGACAAGTT GAAATCTCGT

CAATCAATCA TGAAAATAAT GGACATTATT GATTCGTTAA ATGGAAACAT TCAAACTGAT

GTGGATTCCA ATGAATTGAC TCATTTAGTC AAAGAAGGTT TCACTTGGAC CAATTATGAT

AAACAACAGC TTTCTTTTGA CTGGCGCACT TTTAGTAATG AAGGGCGCAG TATGGTTGAA

CTATACCCAG ATAGTATTGA AAATGTCCGT CATCAATTAC GTGTGTCTTT AAATTTAGAA

AAGCCAGATG AACCAGATCA AGACGGCTAT GTCTTCCATA CGAACGGTGA ATTTTTATAT

CAAAGTGATT ATACCGTTCA AGATGAAGCA GCTGAGGAAA ACGAAATGAC TTCCATCAAC

CGCAATACGT ATATTGGTGT TCCTGCTAAT ACACAGACCO GCCCGTTGCC ATCAGTTAAA

ACGGAAAATG GCTTTATAAA ATAA

EF014-2 (SEQ ID NO:50)

MSRKRKIS LISLVIILVF VTVGSAYFAV AGSYLKKTID KGYVPIKNDY

NEAQNKDSQS FLIMGLDNTI ERKLGTTRTD ANMVITVNNK TKKITYLSLP RDSFVQIDAK

NYQGMQRIEA AYTYDGPTAS VNTVEKLLNI PINHYVVFNF LSFIKLIDAV GGIDVNVKQA

FDGVTKDGPG SIHFDAGKQH LDGTKALSYA RERHSDNDIM RGFRQQEIIQ AVEDKLKSGQ

SIMKIMDIID SLNGNIQTDV DSNELTHLVK EGLTWTNYDK QQLSFDWRTF SNEGRSMVEL

YPDSIENVRH QLRVSLNLEK PDERDQDGYV FHTNGEFLYQ SDYTVQDEAA EENEMTSING

NTYIGVPGNT QTGPLPSVKT ENGFIK

EF014-3 (SEQ ED NO:51)

TGCT

GTAGCGCGTA GCTATTTAAA GAAAACAATT GATAAAGGCT ATGTTCCCAT AAAAAATGAT

TATAATGAAG CGCAAAATAA ACATAGTCAA TCGTTTTTGA TTATGGGGCT AGACAATACA

ATTGAACGGA AATTAGGCAC AACTAGGACT GATGCTATGA TGGTGATTAC CGTGAATAAC

AAGACGAAGA AAATAACCTA TTTAAGTTTG CCACGGGATA GTTTTGTTCA AATTGATGCG

AAAAATTACC AAGGGATGCA GCGAATTGAA GCCGCCTATA CCTACGATGG ACCAACAGCT

TCTGTTAACA CAGTTGAGAA ATTATTGAAT ATTCCAATCA ATCATTACGT TGTGTTTAAC

TTTTTATCTT TTATTAAGTT AATTGATGCG GTTGGCCGCA TAGATGTCAA TGTCAAGCAG

GCGTTTGATG GTGTCACCAA AGACGGGCCA GGATCCATTC ATTTTGATGC ACGGAAACAG

CATTTAGATG GTACGAAAGC TTTATCTTAT GCCCGTGAAA GACATAGCGA TAACGATATT

ATGCGTGGAT TCCGACAACA AGAAATTATT CAAGCAGTTG AAGACAAGTT GAAATCTGGT

CAATCAATCA TGAAAATAAT GGACATTATT GATTCGTTAA ATGGAAACAT TCAAACTGAT

GTGGATTCCA ATGAATTGAC TCATTTAGTC AAAGAAGGTT TGACTTGGAC CAATTATGAT

AAACAACAGC TTTCTTTTGA CTGGCGCACT TTTAGTAATG AAGGGCGCAG TATGGTTGAA

CTATACCCAG ATAGTATTGA AAATGTCCGT CATCAATTAC GTGTGTCTTT AAATTTAGAA

AAGCCAGATG AACGAGATCA AGACGGCTAT GTCTTCCATA CGAACGGTGA ATTTTTATAT

CAAAGTGATT ATACCGTTCA AGATGAAGCA GCTGAGGAAA ACGAAATGAC TTCCATCAAC

GGCAATACGT ATATTGGTGT TCCTGGTAAT ACACAGACCG GCCCGTTGCC ATCAGTTAAA

ACGGAAAATG GCTTTATAAA A

EF014-4 (SEQ ID NO:52)

AV AGSYLKKTID KGYVPIKNDY

NEAQNKDSQS FLIMGLDNTI ERKLGTTRTD AMMVITVNNK TKKITYLSLP RDSFVQIDAK

NYQGMQRIEA AYTYDGPTAS VNTVEKLLNI PINHYVVFNF LSFIKLIDAV GGIDVNVKQA

FDCVTKDGPG SIHFDAGKQH LDGTKALSYA RERHSDNDIM RGFRQQEIIQ AVEDKLKSGQ

SIMKIMDIID SLNGNIQTDV DSNELTHLVK EGLTWTNYDK QQLSFDWRTF SNEGRSMVEL

YPDSIENVRH QLRVSLNLEK PDERDQDGYV FHTNGEFLYQ SDYTVQDEAA EENEMTSING

NTYIGVPGNT QTGPLPSVKT ENGFIK

EF015-1 (SEQ ID NO:53)

TAATTAAAAA TGTGTAAAAA GGGTCTGATG AAAAAAGGAG ACATAATAGT TATTATCTTT

TTAATAGCTA TCTCTTTTTC TCCATATTTT ATTTTTTTTC ACAATAATCC ATTTAACTCC

AAAAGTTTTG ACGACACTAA ATATGCTGTG GTCAAGATAG ATGGGAAAGA GATTGAGCGT

ATAAATTTAG ATGATTCAAA AGAATTTATC AAAACATATT ATCCATCAAA AGGGCAATAT

AATACTATAG AAGTTAAAAA TGGGCACGTT CGTGTAAAAA AAGATAATAG TCCAGATCAA

ATTGCGGTGA AAACAGGATG GATATCAGAA CCAGGGCNAA CTACTATCTG TATTCCTCAC

AGATTCATTT TAGAAATTGT TCAACAATAT TCTAAGGATT ATTATATTTA CTAA

EF015-2 (SEQ ID NO:54)

MK KGDIIVIIFL TAISESPYFI FFHNNPFNSK SFDDTKYAVV KIDGKEIERIL

NLDDSKEFIK TYYPSKGQYN TIEVKNGHVR VKKDNSPDQI AVKTGWISEP GXTSICTPHR

FILEIEVQQYS KDYYIY

EF015-3 (SEQ ID NO:55)

CAATAATCC ATTTAACTCC

AAAAGTTTTG ACGACACTAA ATATGCTGTG GTCAAGATAG ATGGGAAAGA GATTGAGCGT

ATAAATTTAG ATGATTCAAA AGAATTTATC AAAACATATT ATCCATCAAA AGGGCAATAT

AATACTATAG AAGTTAAAAA TGGGCACGTT CGTGTAAAAA AAGATAATAG TCCAGATCAA

ATTGCGGTGA AAACAGGATG GATATCAGAA CCAGGCCNAA CTAGTATCTG TATTCCTCAC

AGATTCATTT TAGAAATTGT TCAACAATAT TCTAAGGATT ATTATATTTA C

EF015-4 (SEQ ID NO:56)

NNPFNSK SFDDTKYAVV KTDGKEIERI

NLDDSKEFIK TYYPSKGQYN TIEVKNGHVR VKKDNSPDQT AVKTGWISEP GXTSICIPHR

FILEIVQQYS KDYYIY

EF016-1 (SEQ ID NO:57)

TGACGGTTGC CCCCGTCCAA TAGAAAGGAG TTTATGATGA AAAAGAAATA TTCTTTAGCC

TTGCTGGTTA TCTGTTGTAG TTTACTCCTA TTTGCAGGTT GTGGTAAAAG AAAAAGCAAC

GAAGATCAAT GGACACGGAT TAACGAAGAA AAACGGATTA TTATTGGCTT AGATGACTCC

TTTGTGCCCA TGGGTTTTCA AGATAAATCA GGCAAAATTG TCGGCTTTGA TGTCGACTTA

GCCAAAGCGG TTTTTAAACT TTATGGCATT TCCGTTGACT TCCAACCGAT TGATTGGTCT

ATGAAAGAAA CAGAATTACA AAATCAAACC ATTGATCTTA TTTGGAACGG CTACACTAAA

ACGAGCGAGC GGGCCGAAAA AGTTCAATTC ACACAACCTT ACATGACGAA CGACCAAGTA

CTTGTTTCTT TAAAAGAAAA AAACATTGCA ACAGCGAGCG ACATGCAAGG CAAAATTTTA

GGCGTTCAAA ACGGCTCTTC TGGCTATGAT GGCTTCGAAA GTCAGCCTGA CGTTTTGAAA

AAATTTGTTA AAGACCAAAC ACCTATTTTA TATGACGGCT TTAATGAAGC TTTCTTAGAT

TTAAAATCTG GTCGAATTGA CGGACTCCTA ATCGATCGCG TTTACGCCAA CTACTATCTT

TCCCACGAAG ATAATTTAAA AAACTATACT ATTTCTCATG TAGGCTATGA CAATGAAGAT

TTTGCTGTGG GCGTCCGCAA ATCAGACAAT CAATTAGTCC AAAAAATCAA TACTGCCTTT

GAAACGTTAC GAAAAGATGG CACCCTTACT AAAATTTCTC AAAAATGGTT TGGAGAGGAC

GTTACAAATA ACACAAAAAT AAACTAA

EF016-2 (SEQ ID NO:58)

MMKKKYSLAL LVICCSLLLF AGCGKRKSNE DQWTRINEEK RIIIGLDDSF

VPMGFQDKSG KIVGFDVDLA KAVFKLYGIS VDFQPIDWSM KETELQNQTI DLIWNGYTKT

SERAEKVQFT QPYMTNDQVL VSLKEKNIAT ASDMQGKILG VQNGSSGYDG FESQPDVLKK

FVKDQTPILY DGFNEAFLDL KSGRIDGLLI DRVYANYYLS HEDNLKNYTI SHVGYDNEDF

AVGVRKSDNQ LVQKINTAFE TLRKDGTLSK TSQKWFGEDV TNNTKIN

EF016-3 (SEQ ID NO:59)

AAGCAAC

GAAGATCAAT GGACACGGAT TAACGAAGAA AAACGGATTA TTATTGGCTT AGATGACTCC

TTTGTGCCCA TGGGTTTTCA AGATAAATCA GGCAAAATTG TCGGCTTTGA TGTCGACTTA

GCCAAAGCGG TTTTTAAACT TTATGGCATT TCCGTTGACT TCCAACCGAT TGATTGGTCT

ATGAAAGAAA CAGAATTACA AAATCAAACC ATTGATCTTA TTTGGAACGG CTACACTAAA

ACGAGCGAGC GGGCCGAAAA AGTTCAATTC ACACAACCTT ACATGACGAA CGACCAAGTA

CTTGTTTCTT TAAAAGAAAA AAACATTGCA ACAGCGAGCG ACATGCAAGG CAAAATTTTA

GGGGTTCAAA ACGGCTCTTC TGGCTATGAT GGCTTCGAAA GTCAGCCTGA CGTTTTGAAA

AAATTTGTTA AAGACCAAAC ACCTATTTTA TATGACGGCT TTAATGAAGC TTTCTTAGAT

TTAAAATCTG GTCGAATTGA CGGACTCCTA ATCGATCGCG TTTACGCCAA CTACTATCTT

TCCCACGAAG ATAATTTAAA AAACTATACT ATTTCTCATG TAGGCTATGA CAATGAAGAT

TTTGCTGTGG GCGTCCGCAA ATCAGACAAT CAATTAGTCC AAAAAATCAA TACTGCCTTT

GAAACGTTAC GAAAAGATGG CACCCTTAGT AAAATTTCTC AAAAATGGTT TGGAGAGGAC

GTTACAAATA ACACAAAAAT AAAC

EF016-4 (SEQ ID NO:60)

SNE DQWTRINEEK RIIIGLDDSF

VPMGFQDKSG KIVGFDVDLA KAVFKLYGIS VDFQPIDWSM KETELQNQTI DLIWNGYTKT

SERAEKVQFT QPYMTNDQVL VSLKEKNIAT ASDMQGKILG VQNGSSGYDG FESQPDVLKK

FVKDQTPILY DGFNEAFLDL KSGRIDGLLI DRVYANYYLS HEDNLKNYTI SHVGYDNEDF

AVGVRKSDNQ LVQKINTAFE TLRKDGTLSK ISQKWFGEDV TNNTKIN

EF017-1 (SEQ ID NO:61)

TGAGGTGTTT TTATGAAAAG CGCAACAAAG CAAAGGCTGT CTTTGGCAGC AATCATGGTT

CTACTTCTCT CGGGCTGTGG AAGTGTTGGG AAAGAAACCA AAAAGCAAGA ACAACAGGTA

TTACGGGTCG GGATTGATTC GGAATTATCA ACGGCAGACG TGTCGTTGGC AATGGATAAT

ACCGCAGCAG ATGTAATGAG CCAAGTAGGG GAGGGACTTT TCTCCTTTGA CGAAAAAGGA

GAAGCGAAAC CAGCATTGGC AACTGAAAAA GTACAGCCCT CCAATGATGG TTTAAGCTAT

ACTTTTACGA TTCGAAAAGA TGCAAAATGG AGTAACGGCG AGCCAATCAC AGCAAATGAT

TTTGAATACT CTTGGAAGCG CACAGTGGAC CCAAAAACAG CTTCCCCGCA AGCGTATTAC

TTTGAAGGGT TAAAAAATTA TCGTGCTATT GTTGACGGTA GCAAATCTAA AGAAGAGTTA

GGGGTAACAG CCATTGATGA CCATACCTTG GAAGTAGAGC TAAGCTATCC TATGAGTTAT

TTTCAACAAT TATTGGCGGT ACCAGCTTTT TATCCTTTAA ATGAAGCATT TGTCGAAAAA

ACGGGCAAAA ACTATGGTAC ATCAGCTGAG TCAACACTTT ACAATGGCGC CTTCACATTA

GAAGGTTGGG ATGGCACGAA TAATACTTGG TCCTATGTGA AGAATAAAAA TTATTGGGAT

CAAGCGAATG TTTCGCTAGA TAAGGTGGAT GTCCAAGTAG TTAAAGAAGT CAATACTGGG

AAAAATCTTT TCGAAGGGAA AGAATTAGAT GTTGTAAAAA TTTCTGGAGA AATTGTTGCA

CAAGAACAAG GCAATGCAGC TTTGAAAATT CGTGAAATTC CTGGAACGTA TTATATCCAA

TTAAATACGC AAAAAGATCT TTTGGCAAAT AAGAATGCAC GTCGAGCAAT AGCATTATCA

TTGAATTCTG AGCGTTTAGC TAAAAATGTT TTAAATGATG GCTCAAAAAA AGCACTTGGC

TTCGTGCCAA CAGGTTTCAC TAATCAACAA ACCCAAAAAG ATTTTGCAGA GGAATTAGGA

GATTTAAATC CTAGTGAACC AGAAAAAGCG AAAGAGTTAT GGCAAACGGC TAAAAAAGAA

TTAGGAATTG AAAAAGCGGA GCTAACGATT TTAAGTTCGG ATACAGAAAA TGCTAAAAAA

ATCAGTGAGT ATGTTCAAGG AGCTTTAGCA GATAATTTAG AAAATTTAAC AGTCAATGTT

TCACCAGTTC CTTTTAATAA TCGTTTAGAA AAAAGTCGCA GCGGAGATTT CGACATTGTG

GTTGGTGGCT GGACGCCAGT ATATGCTGAT CCAATCGATT TCTTAAACTT ACTGCAATCA

AAAAATTCCA ATAATTTTGG TAAATGGTCT AATAAGACCT TTGATCAGTT GCTTCAAGAA

CCAAACGTAA CTTATGCAAA TAAATATGAA GAACGTTGGA AAACATTACA AAAAGCGGAT

CAATTGGTTG CGGAAGAAGC CCCCCTAGTT CCTCTTTATC AATTAACAGA AGCACGCTTA

GTGGCCGATT CTGTCCAAAA TTTAGTCTAT GGTCCATTAG GTTCAGGCTA TTACAAATCA

GTCTCTATCG GCGACAAGTA A

EF017-2 (SEQ ID NO:62)

MKRATKQ RLSLAAIMVL LLSGCGSVGK ETKKQEQQVL RVGIDSELST ADVSLAMDNT

AADVMSQVGE GLFSFDEKGE AKPALATEKV QPSNDGLSYT FTIRKDAKWS NGEPITANDF

EYSWKRTVDP KTASPQAYYF EGLKNYRAIV DGSKSKEELG VTAIDDHTLE VELSYPMSYF

QQLLAVPAFY PLNEAFVEKT GKNYGTSAES TLYNGAFTLE GWDGTNNTWS YVKNKNYWDQ

ANVSLDKVDV QVVKEVNTGK NLFEGKELDV VKISGEIVAQ EQGNAALKIR EIPGTYYIQL

NTQKDLLANK NARPAIALSL NSERLAKNVL NDGSKKALGF VPTGFTNQET QKDFAEELGD

LNPSEPEKAK ELWQTAKKEL GIEKAELTIL SSDTENAKKI SEYVQGALAD NLENLTVNVS

PVPFNNRLEK SRSGDFDIVV GGWTPVYADP IDFLNLLQSK NSNNFGKWSN KTFDQLLQEA

NVTYANKYEE RWKTLQKADQ LVAEEAPLVP LYQLTEARLV ADSVQNLVYG PLGSGYYKSV

SIGDK

EF017-3 (SEQ ID NO:63)

CTGTGG AAGTGTTGGG AAAGAAACCA AAAAGCAAGA ACAACAGGTA


TTACGGGTCG GGATTGATTC GGAATTATCA ACGGCAGACG TGTCGTTGGC AATGGATAAT

ACCGCAGCAG ATGTAATGAG CCAAGTAGGG GAGGGACTTT TCTCCTTTGA CGAAAAAGCA

GAAGCGAAAC CAGCATTGGC AACTGAAAAA GTACAGCCCT CCAATGATGG TTTAAGCTAT

ACTTTTACGA TTCGAAAAGA TGCAAAATGG AGTAACGGCG AGCCAATCAC AGCAAATGAT

TTTGAATACT CTTGGAAGCG CACAGTGGAC CCAAAAACAG CTTCCCCGCA AGCGTATTAC

TTTGAAGGGT TAAAAAATTA TCGTGCTATT GTTGACGGTA GCAAATCTAA AGAAGAGTTA

GGGGTAACAG CCATTGATGA CCATACCTTG GAAGTAGAGC TAAGCTATCC TATGAGTTAT

TTTCAACAAT TATTGGCGGT ACCAGCTTTT TATCCTTTAA ATGAAGCATT TGTCGAAAAA

ACGGGCAAAA ACTATGGTAC ATCAGCTGAG TCAACACTTT ACAATGGCGC CTTCACATTA

GAAGGTTGGG ATGGCACGAA TAATACTTGG TCCTATGTGA AGAATAAAAA TTATTGGGAT

CAAGCGAATC TTTCGCTAGA TAAGGTGGAT GTCCAAGTAG TTAAAGAAGT CAATACTGGG

AAAAATCTTT TCGAAGGGAA AGAATTAGAT GTTGTAAAAA TTTCTGGAGA AATTGTTGCA

CAACAACAAG GCAATGCAGC TTTGAAAATT CGTGAAATTC CTGGAACGTA TTATATCCAA

TTAAATACGC AAAAAGATCT TTTGGCAAAT AAGAATGCAC GTCGAGCAAT AGCATTATCA

TTGAATTCTG AGCGTTTAGC TAAAAATGTT TTAAATGATG GCTCAAAAAA AGCACTTGGC

TTCGTGCCAA CAGGTTTCAC TAATCAAGAA ACGCAAAAAG ATTTTGCAGA GGAATTAGGA

GATTTAAATC CTAGTGAACC AGAAAAAGCG AAAGAGTTAT GGCAAACGGC TAAAAAAGAA

TTAGGAATTG AAAAACCGGA GCTAACGATT TTAAGTTCGG ATACAGAAAA TGCTAAAAAA

ATCAGTGAGT ATGTTCAAGG AGCTTTAGCA GATAATTTAG AAAATTTAAC AGTCAATGTT

TCACCAGTTC CTTTTAATAA TCGTTTAGAA AAAAGTCGCA GCGGAGATTT CGACATTGTG

GTTGGTGGCT GGACGCCAGT ATATGCTGAT CCAATCGATT TCTTAAACTT ACTGCAATCA

AAAAATTCCA ATAATTTTGG TAAATGGTCT AATAAGACCT TTGATCAGTT GCTTCAAGAA

GCAAACGTAA CTTATGCAAA TAAATATGAA GAACGTTGCA AAACATTACA AAAAGCGGAT

CAATTGGTTG CGGAAGAAGC CCCCCTAGTT CCTCTTTATC AATTAACAGA AGCACGCTTA

GTGGCCGATT CTGTCCAAAA TTTAGTCTAT GGTCCATTAG GTTCAGGCTA TTACAAATCA

GTCTCTATCG GCGACAAG

EF017-4 (SEQ ID NO:64)

CGSVGK ETKKQEQQVL RVGIDSELST ADVSLAIADNT

AADVMSQVGE GLFSFDEKGE AKPALATEKV QPSNDGLSYT FTIRKDAKWS NGEPITANDF

EYSWKRTVDP KTASPQAYYF EGLKNYRAIV DGSKSKEELG VTAIDDHTLE VELSYPMSYF

QQLLAVPAFY PLNEAFVEKT GKNYGTSAES TLYNGAFTLE GWDGTNNTWS YVKNKNYWDQ

ANVSLDKVDV QVVKEVNTGK NLFEGKELDV VKISGEIVAQ EQGNAALKIR EIPGTYYIQL

NTQKDLLANK NARRAIALSL NSERLAKNVL NDGSKKALGF VPTGFTNQET QKDFAEELGD

LNPSEPEKAK ELWQTAKKEL GIEKAELTIL SSDTENAKKI SEYVQGALAD NLENLTVNVS

PVPFNNRLEK SRSGDFDIVV GGWTPVYADP IDFLNLLQSK NSNNFGKWSN KTFDQLLQEA

NVTYANKYEE RWKTLQKADQ LVAEEAPLVP LYQLTEARLV ADSVQNLVYG PLGSGYYKSV

SIGDK

EF018-1 (SEQ ID NO:65)

TGTCATTACA ACGATACCAA TTTTAATCAT TTATCCATTA CTACAAAAAC ACTTTATCGG

CGGTATGATG GCCGGTGCAG TAAAAGAATA AAGAAAGTAG GGAACAATAT GAAAAAAGTT

TTAGGCGGTT TATTGGTGGC AACGGCGGTC GTTAGTTTAG CGGCCTGTAG CGGTGGGGAA

AAGAAAGCTA GCTCAGATGT CTCAATTAAG GATCGGTATG AATTAGATGA AAAGACGCCT

GCTTGGAAGT TACATAAGAA GAAAGAACCG ACCAAGATTA AATGGTATAT TAACTCAGAT

TGGACGGCGC TCCCTTTTGG AAAAGACGTG ACCACTGCGC AGATTAAAAA AGACTTAAAT

GTGGATATTG AATTTATTTC CGGCGATGAT TCAAAATTAA ATGCCATGAT TTCAAGTGGA

GATATGCCTG ATATCGTGAC ATTAACTGAA AAAACTGGAC AAGCAGCATT GAAAGCAGAT

TCTTGGGCCT ATTCTTTAAA CGATTTAGCT AAAAAATATG ACCCCTATTT AATGAAAGTT

GTTAACCAAG ATACGTTTAA ATGGTATGCC TTAGAGGATG GAAAAACATA TGGTTACCCT

AATTACTCTA ATACAAAAGC GGATTATGAA AGTGGAAATA TCCCAGTAAA TGATAATTTT

GTTATTCGTG AAGATGTCTA TAATGCATTA GGCAAGCCAG ACGTTTCAAC ACCAGAAAAT

TTTGAAAAAG TCATGCAACA GATTAAAGAA AAATATCCTG AGATGACCCC AATGGGCTTC

ACCACAGTGG GCGATGGTGC AGGACCATTT TTAGACAAAT TACAAGACTT CTTAGGTGTT

CCTTTAGAGG ATAAAAATGG TAAATACTAT GATCGAAATT TAGATAAAGA ATATTTAGAA

TGGTTAAAAA CATTTAATGA TGTTTACCGA GCAGGCAATA TTAGTGATGA TAGCTTCACA

GATGATGGGG CAACGTTTGA TGAAAAAGTG AAACAAGGAA ATTATGCAAC CATGCTCGTT

GCTGGAACCA GTGGTCAAGG TGGGAACTTC ACAGAATTTA TGAAAAAATC TGGCACACGT

TATATAGCCA TTGATGGACC AAGTAGCACT TCTGGCCGAA AACCAACATT AAATCAAACC

GGCATTTCAG GTTGGTTAAG TAATTACATT ACGAAAGATG CGAAAGATCC AGCAAAAGTC

ACTCAACTGT TCACATATTT AATTGATGAA CCGGGACAAA TTTTAACAAA ATATGGCGTT

GAAGGAGTTA CTTATGCGTA CAATGATCAA GGAAAAATTG ATTATTTACC AGAAGTGAAA

AAATTAGAAC AAACAGACAA TGATGCCTAC AACAAAAAAT ATGGCATTAG TCGTTTCCTA

TACTTTAACA ACGACCGTGT CAATAAACTA AAAGTACCAA TGGAAAGTGC TTTAACGCAA

ATGCAAGAAT GCGGCAAAGG AAAATTAGTC CCACATTTCG TAATTGAAAA TATTAATCCA

GATGCAGGAA CGCCGGAAGC TCGTGCGAAT GAAGCGATTG AAACCAAACT AAATACAACC

GTTATTTCAA TGATTCGTGC GAAAGATGAT AAAGCCTTTG ACAAATCTTT AGAAGACTAC

AAAGCATTCT TAAAATCAAA TAAATCGGAT GCAATTGAAA AAATAAAATC TGAGAAAATG

GCGGAAAACA GAGACAAACT TAAGTAA

EF018-2 (SEQ ID NO:66)

MKKV LGGLLVATAV VSLAACSGGE

KKASSDVSIK DRYELDEKTP AWKLDKKKEP TKIKWYTNSD WTALPFGKDV TTAQIKKDLN

VDIEFISGDD SKLNANISSG DMPDIVTLTE KTGQAALKAD SWAYSLNDLA KKYDPYLMKV

VNQDTFKWYA LEDGKTYGYP NYSNTKADYE SGNIPVNDNF VIREDVYNAL GKPDVSTPEN

FEKVMQQIKE KYPEMTPMGF TTVGDGAGPF LDKLQDFLGV PLEDKNGKYY DRNLDKEYLE

WLKTFNDVYR AGNTSDDSFT DDGATFDEKV KQGNYATMLV AGTSGQGGNF TEFMKKSGTR

YIAIDGPSST SGRKPTLNQT GISGWLSNYI TKDAKDPAKV TQLFTYLIDE PGQILTKYGV

EGVTYAYNDQ GKIDYLPEVK KLEQTDNDAY NKKYGISRFL YFNNDRVNKL KVPMESALTQ

MQEWGKGKLV PHFVIENINP DAGTPEARAN EAIETKLNTT VISMTRAKDD KAFDKSLEDY

KAFLKSNKWD AIEKIKSEKM AENRDKLK

EF018-3 (SEQ ID NO:67)

CTGTAG CGGTGGGGAA

AAGAAAGCTA GCTCACATGT CTCAATTAAG GATCGGTATG AATTAGATGA AAAGACGCCT

GCTTGGAAGT TAGATAAGAA GAAAGAACCG ACCAAGATTA AATGGTATAT TAACTCAGAT

TGGACGGCGC TGCCTTTTGG AAAAGACGTG ACCACTGCGC ACATTAAAAA AGACTTAAAT

GTGGATATTG AATTTATTTC CGGCGATGAT TCAAAATTAA ATGCCATGAT TTCAAGTGGA

GATATGCCTG ATATCGTGAC ATTAACTGAA AAAACTGGAC AAGCAGCATT GAAAGCAGAT

TCTTGGGCCT ATTCTTTAAA CGATTTAGCT AAAAAATATG ACCCCTATTT AATGAAAGTT

GTTAACCAAG ATACGTTTAA ATGGTATGCC TTAGAGGATG GAAAAACATA TGGTTACCCT

AATTACTCTA ATACAAAAGC GGATTATGAA AGTGGAAATA TCCCAGTAAA TGATAATTTT

GTTATTCGTG AAGATGTCTA TAATCCATTA CGCAAGCCAG ACGTTTCAAC ACCAGAAAAT

TTTGAAAAAG TCATGCAACA GATTAAAGAA AAATATCCTG AGATGACCCC AATGGGCTTC

ACCACAGTGG GCGATGGTGC AGGACCATTT TTAGACAAAT TACAAGACTT CTTAGGTGTT

CCTTTAGAGG ATAAAAATGG TAAATACTAT GATCGAAATT TAGATAAAGA ATATTTAGAA

TGGTTAAAAA CATTTAATGA TGTTTACCGA GCAGGCAATA TTAGTGATGA TAGCTTCACA

GATGATGGGG CAACGTTTGA TGAAAAAGTG AAACAAGGAA ATTATGCAAC CATGCTCGTT

GCTGGAACCA GTGGTCAAGG TGGGAACTTC ACAGAATTTA TGAAAAAATC TGGCACACGT

TATATAGCCA TTGATGGACC AAGTACCACT TCTCGCCGAA AACCAACATT AAATCAAACC

GGCATTTCAG GTTGGTTAAG TAATTACATT ACGAAAGATG CGAAAGATCC AGCAAAAGTC

ACTCAACTGT TCACATATTT AATTGATGAA CCGGGACAAA TTTTAACAAA ATATGGCGTT

GAAGGAGTTA CTTATGCGTA CAATGATCAA GGAAAAATTG ATTATTTACC AGAAGTGAAA

AAATTAGAAC AAACAGACAA TGATGCCTAC AACAAAAAAT ATGGCATTAG TCGTTTCCTA

TACTTTAACA ACGACCGTGT CAATAAACTA AAAGTACCAA TGGAAAGTGC TTTAACGCAA

ATGCAAGAAT GGGGCAAAGG AAAATTAGTC CCACATTTCG TAATTGAAAA TATTAATCCA

GATGCACGAA CGCCGGAAGC TCGTGCGAAT GAAGCGATTG AAACCAAACT AAATACAACC

GTTATTTCAA TGATTCGTGC GAAAGATGAT AAAGCCTTTG ACAAATCTTT AGAAGACTAC

AAAGCATTCT TAAAATCAAA TAAATGGGAT CCAATTGAAA AAATAAAATC TCAGAAAATG

GCGGAAAACA GAGACAAACT TAAG

EF018-4 (SEQ ID NO:68)

CSGGE

KKASSDVSIK DRYELDEKTP AWKLDKKKEP TKIKWYINSD WTALPFGKDV TTAQIKKDLN

VDIEFISGDD SKLNAMTSSG DMPDIVTLTE KTGQAALKAD SWAYSLNDLA KKYDPYLMKV

VNQDTFKWYA LEDGKTYGYP NYSNTKADYE SGNIPVNDNF VIREDVYNAL GKPDVSTPEN

FEKVMQQIKE KYPEMTPMGF TTVGDGAGPF LDKLQDFLGV PLEDKNGKYY DRNLDKEYLE

WLKTFNDVYR AGNISDDSFT DDGATFDEKV KQGNYATMLV AGTSGQGGNF TEFMKKSGTR

YIAIDGPSST SGRKPTLNQT GISGWLSNYI TKDAKDPAKV TQLFTYLIDE PGQILTKYGV

EGVTYAYNDQ GKIDYLPEVK KLEQTDNDAY NKKYGISRFL YFNNDRVNKL KVPMESALTQ

MQEWGKGKLV PHFVIENINP DAGTPEARAN EAIETKLNTT VISMIRAKDD KAFDKSLEDY

KAFLKSNKWD AIEKIKSEKM AENRDKLK

SF019-1 (SEQ ID NO:69)

TAAAGGAGTT ACACAATGAA ACTTTTAAAA AAGACGGTCC TAATTGGTAC AACCCTTCTT

CTTGGTTCAT TCTTACTCGC AGCTTGTGGT AATACGAATA AAGAAGCCAA CAACGCTGAC

AAAACACATG AAGTAACAGA TACOTTAGGO AATAAAGTAA CCGTCCCCGC GAAACCCAAA

CGGATTATTG CGAGTTATTT AGAAGATTAT CTAGTTGCAT TAGGAGAAAA ACCAGTGGCA

CAATGGACAG TTGGACAAGG CAGCATTCAA GATTATTTAG CGAAAGAATT GAAAGATGTC

CCCACTATTT CCTATGACTT GCCATATGAA GCGGTTCTAA AATTTGAACC TGACTTATTA

TTAATCAGTT CATCTGCTCT AGTTGAAGGC GGTAAATACA AAGAATACAG TAAAATTGCG

CCAACTTATG TAGTCAAAAA CGGCGAAAAT GTCACCTGGC GTGATCAATT GGAAGATATT

GCCACTGTTT TAGATAAAAA AGAACAAGCG AAAAAAGTGT TAGAAGATTA TGATACCTTA

ACCAAAGGCG TCCAAGAATA TCTTGGCAAA AAAGATGCTG GCAAATCTGC GGCAGTCTTA

TGGGTAACCA ACAACCAAGT CTTTATGGTT AGCGATAATC GCTCAAGCGG AACCGTGCTC

TATCAGGACT TAGGCCTCCA AGTTCCAAAA TTAGTGGAAG AAATTTCTAA AAACGCTACT

GCGGATTGGA ATCAAGTTTC TTTAGAAAAA TTAGCTGAGC TTGACGCAGA CCACATTTTC

CTTGTAAACA GCGATGAATC AGCACCTCTT TTCCAAGAAG CAATTTGGAA GAACTTACCT

GCTGTGAAAA ATAACCAAGT TCATACCTAT GATAAAAAAA GTAGTTGGTT ATACAACGGA

CCTATTGCGA ATACTCAAAT TGTTGAAGAT GTAAAAAAAG CGCTCTTAAA TTAA

5F019-2 ((SEQ ID NO:70)

MKLLKK TVLIGTTLLL GSFLLAACGN TNKEANNADK THEVTDTLGN KVTVPAKPKR

IIASYLEDYL VALGEKPVAQ WTVGQGSIQD YLAKELKDVP TISYDLPYEA VLKFEPDLLL

TSSSALVEGG KYKEYSKIAP TYVVKNGENV TWRDQLEDIA TVLDKKEQAK KVLEDYDTLT

KGVQEYLGKK DAGKSAAVLW VTNNQVFMVS DNRSSGTVLY QDLGLQVPKL VEEISKNATA

DWNQVSLEKL AELDADHIEL VNSDESAPLF QEAIWKNLPA VKNNQVHTYD KKSSWLYNGP

IANTQIVEDV KKALLN

EF019-3 (SEQ ID NO:71)

TTGTGGT AATACGAATA AAGAAGCCAA CAACGCTGAC

AAAACACATG AAGTAACAGA TACCTTAGGC AATAAAGTAA CCGTCCCCGC GAAACCCAAA

CGGATTATTG CGAGTTATTT AGAAGATTAT CTAGTTGCAT TAGGAGAAAA ACCAGTGGCA

CAATGGACAG TTGGACAAGG CAGCATTCAA GATTATTTAG CGAAAGAATT GAAAGATGTC

CCCACTATTT CCTATGACTT GCCATATGAA GCGGTTCTAA AATTTGAACC TGACTTATTA

TTAATCAGTT CATCTGCTCT AGTTGAAGGC GGTAAATACA AAGAATACAG TAAAATTGCG

CCAACTTATG TAGTCAAAAA CGGCGAAAAT GTCACCTGGC GTGATCAATT GGAAGATATT

GCCACTGTTT TAGATAAAAA AGAACAAGCG AAAAAAGTGT TAGAAGATTA TGATACCTTA

ACCAAAGGCG TCCAAGAATA TCTTGGCAAA AAAGATGCTG GCAAATCTGC GGCAGTCTTA

TGGGTAACCA ACAACCAAGT CTTTATGGTT AGCGATAATC GCTCAAGCGG AACCGTGCTC

TATCAGGACT TAGGCCTCCA AGTTCCAAAA TTAGTGGAAG AAATTTCTAA AAACGCTACT

GCGGATTGGA ATCAAGTTTC TTTAGAAAAA TTAGCTGAGC TTGACGCAGA CCACATTTTC

CTTGTAAACA GCGATGAATC AGCACCTCTT TTCCAAGAAG CAATTTGGAA GAACTTACCT

GCTGTGAAAA ATAACCAAGT TCATACCTAT GATAAAAAAA GTAGTTGGTT ATACAACGGA

CCTATTGCGA ATACTCAAAT TGTTGAAGAT GTAAAAAAAG CGCTCTTAAA T

EF019-4 (SEQ ID NO:72)

CGN TNKEANNADK THEVTDTLGN KVTVPAKPKR

IIASYLEDYL VALGEKPVAQ WTVGQGSIQD YLAKELKDVP TISYDLPYEA VLKFEPDLLL

ISSSALVEGG KYKEYSKIAP TYVVKNGENV TWRDQLEDIA TVLDKKEQAK KVLEDYDTLT

KGVQEYLGKK DAGKSAAVLW VTNNQVFMVS DNRSSGTVLY QDLGLQVPKL VEEISKNATA

DWNQVSLEKL AELDADHIEL VNSDESAPLF QEATWKNLPA VKNNQVHTYD KKSSWLYNGP

IANTQIVEDV KKALLN

EF020-1 (SEQ ID NO:73)

TGAGGAGATG AGAAAATGAA AAAGGTAGTT TCAATTTTGT TGATGGTTGT TGCAGTCTTC

ACATTAACTG CATGTAATGG TTCTAAATTA GATAAAACAG GTGAAGAATT TAAAAATTCT

ATAATGAAAG ATTCTTCATA TGGTGATGAA TATTCAGAAG ATGGTTTTAG TTTTTTAATA

TATAAAGATA AAGACACTAA TCGTTATTTG GCTGATGTTT GGGTTCCTGT TAAAGATGAA

ACTAGCGCAT TGGAGTATTT TTATTATTAT GATGAAGATA AGCGATTAGA TAGTACTAAA

AGTAAAGTAA CCTTTGATGA TATGAAAGCT AGTGGAAACT ATGAAGTAGT GTATAAATCA

GGGAAATTTA AATAA

EF020-2 (SEQ ID NO:74)

MKKVVS ILLMVVAVFT LTACNGSKLD KTGEEFKNSI MKDSSYGDEY SEDGFSFLIY

KDKDTNRYLA DVWVPVKDET SALEYFYYYD EDKRLDSTKS KVTFDDMKAS GNYEVVYKSG

KFK

EF020-3 (SEQ ID NO:75)

ATGTAATGG TTCTAAATTA GATAAAACAG GTGAAGAATT TAAAAATTCT

ATAATGAAAG ATTCTTCATA TGGTGATGAA TATTCAGAAG ATGGTTTTAG TTTTTTAATA

TATAAAGATA AAGACACTAA TCGTTATTTG GCTGATCTTT GGGTTCCTGT TAAAGATGAA

ACTAGCGCAT TGGAGTATTT TTATTATTAT GATGAAGATA AGCGATTAGA TAGTACTAAA

AGTAAAGTAA CCTTTGATCA TATGAAAGCT AGTGGAAACT ATGAAGTAGT GTATAAATCA

GGGAAATTTA AA

EF020-4 (SEQ ID NO:76)

CNGSKLD KTGEEFKNSI MKDSSYGDEY SEDGFSFLILY

KDKDTNRYLA DVWVPVKDET SALEYFYYYD EDKRLDSTKS KVTFDDMKAS GNYEVVYKSG

KFK

EF021-1 (SEQ ID NO:77)

TAGTTGTTTA AATACATTAA ACTATTTTTA GGAGGCTTTA CAGAAATGAA AAAAGCAAAA

TTATTCGGTT TTAGTTTGAT TGCATTAGGT TTATCAGTTT CACTTGCAGC ATGTGGTGGT

GGCAAAGGCA AAACCGCTGA AAGCGGCGGT GGCAAAGGGG ATGCAGCGCA TAGTGCTGTA

ATOATTACAG ATACAGGCGG CGTGGATGAC AAGTCGTTCA ACCAATCTTC TTGGGAAGGA

TTGCAAGCTT GGGGTAAAGA ACATGATTTA CCAGAAGGTT CAAAAGGGTA TGCATATATT

CAATCGAATG ATGCAGCTGA CTATACAACC AATATTGACC AAGCGGTATC AAGTAAATTC

AACACAATCT TTGGTATTGG CTACTTGCTA AAAGATGCAA TTTCTTCTGC AGCAGATGCC

AACCCTGATA CAAACTTTGT TTTAATCGAT GATCAAATCG ATGGCAAAAA GAATGTCGTT

TCTGCAACAT TTAGAGATAA TGAAGCAGCT TACTTAGCCG GTGTTGCTGC TGCAAATGAA

ACAAAAACGA ACAAAGTCCG TTTTGTTGGT GCTGAAGAAG GGGTCGTAAT TGACCGTTTC

CAAGCTGGTT TTGAAAAAGG TGTGGCTGAT GCTGCGAAAG AATTAGGTAA AGAAATTACT

GTTGATACGA AATATGCGGC TTCATTTGCT GATCCTGCCA AAGGGAAAGC TTTAGCTGCT

GCAATGTACC AAAACGGCGT TGATATCATC TTCCATGCTT CTGGTGCGAC TGGACAAGGG

GTCTTCCAAG AAGCAAAAGA CTTGAATGAA TCAGGTTCTG GCGACAAAGT TTGGGTAATC

GGCGTTGACC GCGATCAAGA TGCTGATGGC AAGTACAAAA CAAAAGACGG CAAAGAAGAC

AACTTCACGT TAACTTCAAC GCTTAAAGGT GTCGGCACAG CGGTTCAAGA TATTGCCAAC

CGTGCGTTAG AAGACAAATT CCCTGGTGGC GAACATTTAG TTTATGGATT AAAAGATGGT

GGCGTTGACT TAACAGACGG CTATTTAAAC GACAAAACAA AAGAAGCTGT TAAAACAGCA

AAAGATAAAG TAATCTCAGG TGACGTAAAA GTCCCAGAAA AACCAGAATA A

EF021-2 (SEQ ID NO:78)

MKKAKL FGFSLIALGL SVSLAACGGG KGKTAESGGG KGDAAHSAVI

ITDTGGVDDK SFNQSSWEGL QAWGKEHDLP EGSKGYAYIQ SNDAADYTTN IDQAVSSKFN

TIFGIGYLLK DAISSAADAN PDTNFVLIDD QIDGKKNVVS ATFRDNEAAY LAGVAAANET

KTNKVGFVGG EEGVVIDRFQ AGFEKGVADA AKELGKEITV DTKYAASFAD PAKGKALAAA

MYQNGVDIIF HASGATGQGV FQEAKDLNES GSGDKVWVIG VDRDQDADGK YKTKDGKEDN

FTLTSTLKGV GTAVQDIANR ALEDKFPGGE HLVYGLKDGG VDLTDGYLND KTKEAVKTAK

DKVISGDVKV PEKPE

EF021-3 (SEQ ID NO:79)

ATGTGGTGGT

GGCAAAGGCA AAACCGCTGA AAGCGGCGGT GGCAAAGGGG ATCCAGCGCA TAGTGCTGTA

ATCATTACAG ATACAGGCGG CGTGGATGAC AAGTCGTTCA ACCAATCTTC TTGGGAAGGA

TTGCAAGCTT CGGGTAAAGA ACATGATTTA CCAGAAGGTT CAAAAGGCTA TGCATATATT

CAATCGAATG ATGCAGCTGA CTATACAACC AATATTGACC AAGCGGTATC AAGTAAATTC

AACACAATCT TTGGTATTGG CTACTTGCTA AAAGATGCAA TTTCTTCTGC AGCAGATGCC

AACCCTGATA CAAACTTTGT TTTAATCGAT GATCAAATCG ATGGCAAAAA GAATGTCGTT

TCTGCAACAT TTAGAGATAA TGAAGCAGCT TACTTAGCCG GTGTTGCTGC TGCAAATGAA

ACAAAAACGA ACAAAGTCGG TTTTGTTGGT GGTGAAGAAG GGGTCGTAAT TGACCGTTTC

CAAGCTGGTT TTGAAAAAGG TGTGGCTGAT GCTGCGAAAG AATTAGGTAA AGAAATTACT

GTTGATACGA AATATGCGCC TTCATTTGCT GATCCTGCCA AAGGGAAAGC TTTAGCTGCT

GCAATGTACC AAAACGGCGT TGATATCATC TTCCATGCTT CTCGTGCGAC TCGACAAGGG

GTCTTCCAAG AAGCAAAAGA CTTGAATGAA TCAGGTTCTG GCGACAAAGT TTGGGTAATC

GGCGTTGACC GCGATCAAGA TGCTGATGGC AAGTACAAAA CAAAAGACGG CAAAGAAGAC

AACTTCACGT TAACTTCAAC GCTTAAAGGT GTCGGCACAG CGGTTCAAGA TATTGCCAAC

CGTGCGTTAG AAGACAAATT CCCTGGTGGC GAACATTTAG TTTATGGATT AAAAGATGGT

GGCGTTGACT TAACAGACGG CTATTTAAAC GACAAAACAA AAGAAGCTGT TAAAACAGCA

AAAGATAAAG TAATCTCAGG TGACGTAAAA GTCCCAGAAA AACCAGAA

EF021-4 (SEQ ID NO:80)

CGGG KCKTAESGGG KGDAAHSAVI

ITDTGGVDDK SFNQSSWEGL QAWGKEHDLP EGSKGYAYIQ SNDAADYTTN IDQAVSSKFN

TIFGIGYLLK DAISSAADAN PDTNFVLIDD QIDGKKNVVS ATFRDNEAAY LAGVAAANET

KTNKVGFVGG EEGVVIDRFQ AGFEKCVADA AKELGKEITV DTKYAASFAD PAKGKALAAA

MYQNGVDIIF HASGATGQGV FQEAKDLNES GSGDKVWVIG VDRDQDADGK YKTKDGKEDN

FTLTSTLKGV GTAVQDIANR ALEDKFPGGE HLVYGLKDGG VDLTDGYLND KTKEAVKTAK

DKVISGDVKV PEKPE

EF022-1 (SEQ ID NO:81)

TAAGAGCATA AAAAAATGAA GAGTTATACG AGAAACAAGA TGAAAAAGTA TTTAAAAATC

ACAATGGTTT GTATTTTATT GGTAGCATTT TTAGCTGGGT GTACCAATAA AAATGAAAAT

AAAAAGAAAC AGAAAAATAC CAAAGAAGCC GTTCAACTGA TGTCACCCTC GGAATTAACA

ACGCTCAACA CCTCTGTATT ATTGGATTTT CCACATGCTA TTGTCCAAAC TGCAGCGTTT

GAAGGGTTAT ATAGTTTAGA TGAACAAGAC CAATTGGTAC CAGCCGTAGC AAAAGCATTG

CCGATGATTT CAGAAGATGG AAAAACCTAC ACGATTTCTT TGAGAAAAGA AGCGGTTTGG

AGTAACGATG ATCCTGTCAC AGCACATGAT TTTGAATATG CTTGGAAAAA AATGATTGAT

CCTAAAAACG GCTTTGTTTA TAGCTTCCTC ATCGTTGAAA CAATTCAAAA TGGTGCAGAA

ATCTCAGCGG GGAAATTAGC ACCCAATGAA CTAGGTGTCA CAGCTGTGGA TGATTATACA

TTAAAGGTGA CCCTCAAAGA GCCAAAACCG TACTTTACGT CCTTGTTAGC TTTTCCGACA

TTTTTCCCGC AAAATCNAAA AGTAGTCGAA CAATTTGGTG CGGACTATGG AACTGCTAGT

GATAAAGTCG TCTATAATGG TCCGTTCGTG GTAAAAGATT GGCAGCAAAC AAAGATGGAC

TGCCAACTAG CAAAAAATAA TCGCTATTGG GATCACCAGA ACGTGCGCTC AGACATTATC

AATTATACAG TTATCAAAGA AACATCTACC GCATTGAATC TTTTTGAAGA TGGACAATTA

GATGTGGCTA CACTAAGTGG TGAACTCGCG CAACAGAATA AAAATAATAC GTTGTATCAT

TCGTATCCAA CAGCGACAAT GAACTATTTG CGCTTAAATC AAAAACGGNA AGGGCAAGCN

ACGCCGCTTG CAAACGAAAA CCTGCGTAAA GCATTGGCTT TAGGAATAGA TAAAGAAAAT

CTAGTCAATA ATATTATTGC AGATGGTTCT AAAGCCCTAC ATGGTGCGAT TACGGAAGGC

TTTGTGGCGA ATCCCACAAC GGGTCTCGAT TTTCGTCAAG AAGCAGGTAA TTTAATGGTT

TATAACAAAG AAAAAGCGCA AAGTTATTGG AAAAAAGCAC AAGCAGAATT AGGAGAAAAG

GTTAACGTTG AATTGATGGT AACAGATGAT GGTTCTTACA AAAAAATTGG TGAAAGTTTG

CAAGGCTCGC TACAAGAATT GTTTCCTGGT TTGACAATAG AGCTAACCGC ATTGCCGACT

GAAGCTGCAT TGAACTTTGG GCCACAAAGT GACTATGATT TATTCTTAAT TTACTGGACA

CCAGACTATC AAGACCCTAT TTCTACCCTG ATGACTTTAT ACAAGGGCAA TGATCGCAAT

TATCAGAACC CTGTCTATGA CAAATTATTA GATGAAGCAG CCACAACCTA TGCCTTAGAG

CCAGAAAAAA GATGGGCGAC ACTGATTGCA GCTGAAAAAG AAGTGATTGA AACGACTGCT

GGCATGATTC CACTTAGCCA AAATGAACAA ACAGTCCTGC AAAATGATAA AGTCAAAGGC

TTGAATTTTC ATACCTTTGG CGCTCCATTA ACGTTAAAAA ATGTTTATAA GGAAAAATAA

EF022-2 (SEQ ID NO:82)

MKKYLKIET MVCILLVGFL AGCTNKNENK KKQKNTKEAV QLMSPSELTT

LNTSVLLDFP DAIVQTAAFE GLYSLDEQDQ LVPAVAKALP MISEDGKTYT ISLRKEAVWS

NDDPVTAHDF EYAWKKMIDP KNGFVYSFLI VETIQNGAEI SAGKLAPNEL GVTAVDDYTL

KVTLKEPKPY FTSLLAFPTF FPQNXKVVEQ FGADYGTASD KVVYNGPFVV KDWQQTKMDW

QLAKNNRYWD HQNVRSDIIN YTVIKETSTA LNLFEDCQLD VATLSGELAQ QNKNNTLYHS

YPTATHNYLR LNQKRXGQAT PLANENLRKA LALGIDKENL VNNIIADGSK ALHGAITEGF

VANPTTGLDF RQEAGNLMVY NKEKAQSYWK KAQAELGEKV NVELMVTDDG SYKKICESLQ

GSLQELFPGL TIELTALPTE AALNFGRESD YDLFLIYWTP DYQDPISTLM TLYKGNDRNY

QNPVYDKLLD EAATTYALEP EKRWATLIAA EKEVIETTAG MIPLSQNEQT VLQNDKVKGL

NFHTFGAPLT LKNVYKEK

EF022-3 (SEQ ID NO:83)

CT GTACCAATAA AAATGAAAAT

AAAAAGAAAC ACAAAAATAC CAAAGAAGCC GTTCAACTGA TGTCACCCTC GGAATTAACA

ACGCTCAACA CCTCTGTATT ATTGGATTTT CCAGATGCTA TTGTCCAAAC TGCAGCGTTT

GAAGGGTTAT ATAGTTTAGA TGAACAAGAC CAATTGCTAC CACCCGTAGC AAAAGCATTG

CCGATGATTT CAGAAGATGG AAAAACCTAC ACGATTTCTT TGAGAAAAGA AGCGGTTTGG

AGTAACGATG ATCCTGTCAC AGCACATGAT TTTCAATATG CTTCGAAAAA AATGATTGAT

CCTAAAAACG GCTTTGTTTA TAGCTTCCTC ATCGTTGAAA CAATTCAAAA TGGTGCAGAA

ATCTCAGCGG GGAAATTAGC ACCCAATGAA CTAGGTGTCA CAGCTGTGGA TGATTATACA

TTAAAGGTGA CGCTCAAAGA GCCAAAACCG TACTTTACGT CCTTGTTAGC TTTTCCGACA

TTTTTCCCGC AAAATCNAAA AGTAGTCGAA CAATTTGGTG CGGACTATGG AACTGCTAGT

GATAAAGTCG TCTATAATGG TCCGTTCGTG GTAAAAGATT GGCAGCAAAC AAAGATGGAC

TGGCAACTAG CAAAAAATAA TCGCTATTGG GATCACCAGA ACGTGCGCTC AGACATTATC

AATTATACAG TTATCAAAGA AACATCTACC GCATTGAATC TTTTTGAAGA TGGACAATTA

GATGTGGCTA CACTAAGTGG TGAACTGGCG CAACAGAATA AAAATAATAC GTTGTATCAT

TCGTATCCAA CACCGACAAT GAACTATTTG CGCTTAAATC AAAAACGGNA AGGGCAAGCN

ACGCCGCTTC CAAACGAAAA CCTGCGTAAA GCATTGGCTT TAGGAATAGA TAAAGAAAAT

CTAGTCAATA ATATTATTCC AGATGGTTCT AAAGCGCTAC ATGGTGCGAT TACGGAAGGC

TTTGTGGCGA ATCCCACAAC GGGTCTCGAT TTTCGTCAAG AAGCAGGTAA TTTAATGGTT

TATAACAAAG AAAAAGCGCA AAGTTATTGG AAAAAAGCAC AAGCAGAATT AGGAGAAAAG

GTTAACGTTG AATTGATGGT AACAGATGAT GGTTCTTACA AAAAAATTGG TGAAAGTTTG

CAAGGCTCGC TACAAGAATT GTTTCCTGGT TTGACAATAG AGCTAACCGC ATTGCCGACT

GAAGCTGCAT TGAACTTTGG GCGAGAAAGT GACTATGATT TATTCTTAAT TTACTGGACA

CCAGACTATC AAGACCCTAT TTCTACCCTG ATGACTTTAT ACAAGGGCAA TGATCGCAAT

TATCAGAACC CTGTCTATGA CAAATTATTA GATGAAGCAG CCACAACCTA TGCCTTAGAG

CCACAAAAAA GATGGGCGAC ACTGATTGCA GCTGAAAAAG AAGTGATTGA AACGACTGCT

GGCATGATTC CACTTAGCCA AAATGAACAA ACAGTCCTGC AAAATGATAA AGTCAAAGGC

TTGAATTTTC ATACCTTTGG CGCTCCATTA ACGTTAAAAA ATGTTTATAA CGAAAAA

EF022-4 (SEQ ID NO:84)

CTNKNENK KKQKNTKEAV QLMSPSELTT

LNTSVLLDFP DAIVQTAAFE GLYSLDEQDQ LVPAVAKALP MISEDGKTYT ISLRKEAVWS

NDDPVTAHDF EYAWKKMIDP KNGFVYSFLI VETIQNGAEI SAGKLAPNEL GVTAVDDYTL

KVTLKEPKPY FTSLLAFPTF FPQNXKVVEQ FGADYGTASD KVVYNGPFVV KDWQQTKMDW

QLAKNNRYWD HQNVRSDIIN YTVIKETSTA LNLFEDGQLD VATLSGELAQ QNKNNTLYHS

YPTATMNYLR LNQKRXGQAT PLANENLEKA LALGTDKENL VNNIIADGSK ALHGAITEGE

VANPTTGLDF RQEAGNLMVY NKEKAQSYWK KAQAELGEKV NVELMVTDDG SYKKIGESLQ

GSLQELFPGL TIELTALPTE AALNFGRESD YDLFLIYWTP DYQDPISTLM TLYKGNDENY

QNPVYDKLLD EAATTYALEP EKRWATLIAA EKEVIETTAG MIPLSQNEQT VLQNDKVKGL

NFHTFCAPLT LKNVYKEK

EF023-1 (SEQ ID NO:85)

TAAAATGGAG GGATCGGTAT GAAGAAATTA AAAATGTTAG GATGCGTCGG GTTCCTTTTA

GCTTTAACGG CTTGTCAGGC GGGAACGGGA AACTCGGCTG ATAGTAACAA AGCAGCGGAA

CAAAAAATTG CAATTAGTTC TGAAGCCGCT ATTTCGACAA TGGAACCACA CACAGCGGGG

GATACGACCT CGACTTTAGT CATCAATCAA GTTTATGAAG GACTCTATGT TTTAGGTAAA

GAAGATGAAT TAGAGTTGGG GGTCGCTGCG GAAGAACCAG CGATTTCTGA AGATGAAACC

CTTTATACAT TTAACATTAG AGAAGATCCC AAATGGTCGA ATGATGATCC AGTAACAGCA

AACGACTTTG TTTATGCATG GCAACAAGTT GCTTCCCCTA AATCAGGATC GATTCATCAA

GCTTTATTTT TTCATGTCAT TAAAAATCCT AACCAAATTG CTTTAGAAGG CGCAGATGTG

AATACTCTTG GGCTTAAGGC GCTAGATGAT AAAACGTTAG AAATAACTTT AGAACGGCCC

ACCCCTTATT TGAAATCATT ACTTTCGTTT CCTGTTTTGT TTCCACAAAA TGAAAAATAT

ATCAAAGAAC AAGGGGATAA ATATGCTACT GATGCAGAAC ATTTGATTTA TAATGGTCCT

TTTAAATTGA AAGAATGGGA TAATGCCTCT TCTGATGACT GGACCTACCA AAAAAATGAT

ACOTATTOGO ATGCTGAAAA AGTTAAATTA ACAGAAGCGA AAGTTTCAGT AATTAAGAGC

CCAACGACAC CGGTGAATTT GTTTGACTCC AATGAATTCG ATGTAGTGAA TAAGCTAAGT

GCTGAATTTA TTCCTGGTTA TGTTGATAAT CCACCCTTTC TTTCAATTCC TCAATTCGTC

ACATACTTTT TAAAAATGAA CAGCGTTCGT GATGGAAAAG AAAATCCGGC TTTAGCGAAC

AACAATATTC GTAAAGCGTT GGCACAAGCT TTTGATAAAG AAAGTTTTGT AAAAGAAGTC

TTGCAAGATC AATCAACGGC TACACATCAA GTAATTCCGC CGGGACAAAC GATTGCGCCA

GATCCAACAG ATTTCACAAA ACTAGCTGCT AAGAAAAATA ACTACTTAAC CTACGATACA

CCGAAACCAA AACAATTCTC GGAAAAAGGG AAAAAAGAAA TTGGGCTCCA TAAAATCAAA

TTAGAATTTT TAACAGATGA TACAGACAGC GCCAAAAAAG CTGCTGAGTT TTTCCAATTT

CAATTGGAAG AAAATCTAGA TGGATTAGAA GTGAATGTTA CTCAAGTTCC TTTTACTATT

CGTGTTGATC GTCATCAAAC GAGACACTAT CATTTAGAAT TATCTCCTTG GGGAACCGAT

TATCGTGATC CATTAACAGT TATGCGCATC TTTACTTCGG ATAGTACCTT GGGCGGCGTA

ACGTTCAAGA GTGATACGTA TGATCAATTA ATTCAAGAAA CTAGAACAAC ACATGCGGCT

GATCAAGAGG CTCGTTTAAA TGACTTTGCT CAAGCACAAG ATATTTTGGT GAATCACGAA

ACCGTTTTAG CACCAATCTA CAATCGAAGC ATTTCTGTAT TAGCTAATCA AAAAATCAAG

GATCTGTATT GGCATTCATT TGGACCCACG TACAGTTTAA AATGGGCTTA TGTTAACTAA

EF023-2 (SEQ ID NO:86)

MKKLK MLGCVGLLLA LTACQAGTGN SADSNKAAEQ KIAISSEAAI STNEPHTAGD

TTSTLVMNQV YECLYVLCKE DELELGVAAE EPAISEDETV YTFKIREDAK WSNDDPVTAN

DFVYAWQQVA SPKSCSIHQA LFFDVIKNAK EIALEGADVN TLGVKALDDK TLEITLERPT

PYLKSLLSFP VLFPQNEKYI KEQGDKYATD AEHLIYNCPF KLKEWDNASS DDWTYEKNDT

YWDAEKVKLT EAKVSVIKSP TTAVNLFDSN ELDVVNKLSG EFTPGYVDNP AFLSIPQFVT

YELKNNSVRD GKENPALANN NIRKALAQAF DKESFVKEVL QDQSTATDQV IPPGQTIAPD

GTDFTKLAAK KNNYLTYDTA KAKEFWEKGK KEIGLDKIKL EFLTDDTDSA KKAAEFFQFQ

LEENLDGLEV NVTQVPFTIR VDRDQTRDYD LELSGWGTDY RDPLTVMRIF TSDSTLGGVT

FKSDTYDQLI QETRTTHAAD QEARLNDFAQ AQDILVNQET VLAPTYNRSI SVLANQKIKD

LYWHSFGPTY SLKWAYVN

EF023-3 (SEQ ID NO:87)

GGCAACGGGA AACTCGGCTG ATAGTAACAA AGCAGCGGAA

CAAAAAATTG CAATTACTTC TGAAGCGGCT ATTTCGACAA TGGAACCACA CACAGCCGGG

GATACGACCT CGACTTTAGT CATGAATCAA GTTTATGAAG GACTCTATGT TTTACGTAAA

GAAGATGAAT TAGAGTTGGG GGTCGCTGCC GAAGAACCAG CGATTTCTGA ACATGAAACC

GTTTATACAT TTAAGATTAG AGAAGATGCC AAATGGTCGA ATGATGATCC AGTAACAGCA

AACGACTTTG TTTATGCATG GCAACAAGTT GCTTCCCCTA AATCAGGATC GATTCATCAA

GCTTTATTTT TTGATGTCAT TAAAAATGCT AAGGAAATTG CTTTAGAAGG CGCAGATGTG

AATACTCTTG GCCTTAAGGC GCTAGATGAT AAAACGTTAG AAATAACTTT AGAACCGCCC

ACCCCTTATT TGAAATCATT ACTTTCGTTT CCTGTTTTGT TTCCACAAAA TGAAAAATAT

ATCAAAGAAC AAGGGGATAA ATATGCTACT GATGCAGAAC ATTTGATTTA TAATGGTCCT

TTTAAATTGA AAGAATGGGA TAATGCCTCT TCTGATGACT GGACCTACGA AAAAAATGAT

ACGTATTGGG ATGCTGAAAA AGTTAAATTA ACAGAAGCGA AAGTTTCAGT AATTAAGACC

CCAACGACAG CGGTGAATTT GTTTGACTCG AATGAATTGG ATGTAGTGAA TAAGCTAAGT

GGTGAATTTA TTCCTCGTTA TGTTGATAAT CCAGCCTTTC TTTCAATTCC TCAATTCGTC

ACATACTTTT TAAAAATGAA CAGCGTTCGT GATGGAAAAG AAAATCCGGC TTTAGCGAAC

AACAATATTC GTAAAGCGTT GGCACAAGCT TTTGATAAAG AAAGTTTTGT AAAAGAAGTC

TTGCAAGATC AATCAACGGC TACAGATCAA GTAATTCCGC CGGGACAAAC CATTGCGCCA

GATGGAACAG ATTTCACAAA ACTAGCTGCT AAGAAAAATA ACTACTTAAC CTACGATACA

GCGAAAGCAA AAGAATTCTG GGAAAAAGGG AAAAAAGAAA TTGGGCTGGA TAAAATCAAA

TTAGAATTTT TAACAGATGA TACAGACAGC GCCAAAAAAG CTGCTGAGTT TTTCCAATTT

CAATTCGAAG AAAATCTAGA TGGATTAGAA GTGAATGTTA CTCAAGTTCC TTTTACTATT

CGTGTTGATC GTGATCAAAC GAGAGACTAT GATTTAGAAT TATCTGGTTG GGGAACCGAT

TATCGTGATC CATTAACAGT TATGCGCATC TTTACTTCGG ATAGTACCTT GGGCGGCGTA

ACGTTCAAGA GTGATACGTA TGATCAATTA ATTCAAGAAA CTAGAACAAC ACATGCGGCT

GATCAAGAGG CTCGTTTAAA TGACTTTGCT CAAGCACAAG ATATTTTGGT GAATCAGGAA

ACGGTTTTAG CACCAATCTA CAATCGAAGC ATTTCTGTAT TAGCTAATCA AAAAATCAAG

GATCTGTATT GGCATTCATT TGGACCCACG TACAGTTTAA AATGGGCTTA TGTTAAC

EF023-4 (SEQ ID NO:88)

GTGN SADSNKAAEQ KIAISSEAAI STMEPHTAGD

TTSTLVMNQV YEGLYVLGKE DELELGVAAE EPATSEDETV YTFKIREDAK WSNDDPVTAN

DFVYAWQQVA SPKSGSIHQA LFFDVIKNAK EIALEGADVN TLGVKALDDK TLEITLERFT

PYLKSLLSFP VLFPQNEKYT KEQGDKYATD AEHLIYNGPF KLKEWDNASS DDWTYEKNDT

YWDAEKVKLT EAKVSVIKSP TTAVNLFDSN ELDVVNKLSG EFIPGYVDNP AFLSIPQFVT

YFLKNNSVRD GKENPALANN NIRKALAQAF DKESFVKEVL QDQSTATDQV IPPGQTIAPD

GTDFTKLAAK KNNYLTYDTA KAKEEWEKOK KEIGLDKTKL EFLTDDTDSA KKAAEFFQFQ

LEENLDGLEV NVTQVPFTIR VDRDQTRDYD LELSGWGTDY RDPLTVMRIF TSDSTLGGVT

FKSDTYDQLI QETRTTHAAD QEARLNDFAQ AQDILVNQET VLAPIYNRSI SVLANQKIKD

LYWHSFGPTY SLKWAYVN

EF024-1 (SEQ ID NO:89)

TAATGGCCGT TTCGTCTACT AATAAAGAGG ATGAAGCTAC TCAAATGGCG TTGGCAATGG

AACAAGGATC ATAAAAAAGG AGAAGTGAGC ATGAAAAAAG TACTACCTTT TATTGCCTTA

GTCGGCTTGT TATTGTTGTC AGGTTGTGGA ACAGATATGA AAAAGATATT GACTGCCGAT

GGTGGTAAAT GGAAAGTGGA AGAAACACGT GCAACTTACA CTTTTTTTGA TGACGGTAAA

TTTTCAGCTA ATGACTCAGA GGATACTGTT AGTGGGACAT ACACTTATGA TGAAAAAAAT

AAAAAAATAA CCTTTGACNT TACTAGCAGN AACTCTTTCA TTATGGAAAA AGTNGANTNC

AANGNTANCA AGATTACAGG GGAAATTGGC GAAAAACAAA GAACACTTAT AAAACAAAAA

ACAGAATAA

5F024-2 (SEQ ID NO:90)

M KKVLPFIALV GLLLLSGCGT DMKKILTADG

GKWKVEETRA TYTFFDDGKF SANDSEDSVS GTYTYDEKNK KITFDXTSXN SFIMEKVXXX

XXKITGEIGE KQRTLIKQKT E

EF024-3 (SEQ ID NO:91)

ATT GACTGCCGAT

GGTGGTAAAT GGAAAGTGGA AGAAACACGT GCAACTTACA CTTTTTTTGA TGACGGTAAA

TTTTCAGCTA ATGACTCAGA GGATAGTGTT AGTGGGACAT ACACTTATGA TGAAAAAAAT

AAAAAAATAA CCTTTGACNT TACTAGCAGN AACTCTTTCA TTATGGAAAA AGTNGANTNC

AANGNTANCA AGATTACAGO GGAAATTGGC GAAAAACAAA GAACACTTAT AAAACAAAAA

ACAGAA

EF024-4 (SEQ lED NO:92)

LTADG

GKWKVEETRA TYTFFDDGKF SANDSEDSVS GTYTYDEKNK KITFDXTSXN SFIMEKVXXX

XXKIETGEIGE KQRTLIKQKT E

SF025-1 (SEQ ID NO:93)

TGAATGAAAC ATATTAAAGG AATGTTGGTT TTTATCGGAT TATTTATTTT GGTTGGTTGT

GCGCCAGATC AAGAGCCAAC GAAACAAACA ACAAGTGGTC CGCAAGAGAC AAAGCAAGTG

AAGCAAGTTA CCGTCACCAA TCAAACGACT TCTGCGGTGG AAAAACAAGC GCCGACTAAA

AATGACGAAC TGATTGCTAA TCAATTGACT TTTGATTCTC ATGAATACAC GTACGAAGTG

GTTACAGGGG CCACACAAAC GACATTTGGA ACAACCCCAC CAGCAAAATA TACACCGGAA

GAAAAAAAGA AAAAAATGTT TTGGTCCAAT CAACCGCCTT TGGGATTAAT GACGGGTAAC

TATTATAAAA ATGAAGGTGT ATTTACTGGC GGAAATTACG GCATTGTAGA GATTATTACG

GAACCTGAAA CGCAAAGGAT TCTGAATGTT GAGTTTACAG AGTTTGCTAG TGATCCTTAT

TATGATACAC GCTATTCGGG TGTCAACAAA CGCCTGTCGG ATTATCCTGA ATTTCAAGCA

AGCAACACGC GTACAGACGA TACGTTAGTC ACCGTTGTTA ATGGTATTAC TTATGTAGAA

AAACAAATGC GTGACGAAAA TCGTGTTACA GGTAATTTTT ATACGGTACG CGGTTCATCA

ACTTCTGCGC GTGAAGGATT AATCCCTTTA GCAGCAGAGA TGGACACTTG GCTAAAAGAG

CCATCGAAAG AAACCTATAT CGGTTACGCA GAAGATTTAG GCAATGGCCT AATCGCTCGA

CTTCAAGTGA TAACAGAAGA CCAGAAAATA AAACATGTCA GCTATGATGA ATACTTTTCA

GATGAACAGG AAAAAATCAC AGAAACAGCC TGCGGCCTTT TTATCGTCAA TCGAAATATT

ATTCACCAGG ATACAATAAA CAAACCAACA ATTCTTTTAT TCATTTTGTA G

EF025-2 (SEQ ID NO:94)

MKHIKGMLVF IGLFILVGCA PDQEPTKQTT SGPQETKQVK QVTVTNQTTS AVEKQAPTKN

DELIANQLTF DSHEYTYEVV TGATQTTFGT TPPAKYTPEE KKKKMFWSNQ PPLGLMTGNY

YKNEGVFTGG NYGIVEIITE PETQRTLNVE FTEFASDPYY DTRYSGVNKR LSDYPEFQAS

NTRTDDTLVT VVNGITYVEK QMRDENRVTG NFYTVRGSST SAREGLMPLA AEMDTWLKEP

SKETYIGYAE DLGNGLIARL QVITEEQKIK HVSYDEYFSD EQEKITETAC GLFIVNRNII

HQDTINKPTT LLFIL

EF025-3 (SEQ ID NO:95)

AAC GAAACAAACA ACAAGTGGTC CGCAAGAGAC AAAGCAAGTG

AAGCAAGTTA CCGTCACCAA TCAAACGACT TCTGCGGTGG AAAAACAAGC GCCGACTAAA

AATGACGAAC TGATTGCTAA TCAATTGACT TTTGATTCTC ATGAATACAC GTACGAAGTC

GTTACAGGGG CCACACAAAC GACATTTGGA ACAACCCCAC CAGCAAAATA TACACCGGAA

GAAAAAAAGA AAAAAATGTT TTGGTCCAAT CAACCGCCTT TGGGATTAAT GACGGGTAAC

TATTATAAAA ATGAAGGTGT ATTTACTGGC GGAAATTACG GCATTGTAGA GATTATTACG

GAACCTGAAA CGCAAAGGAT TCTGAATGTT GAGTTTACAG ACTTTGCTAG TGATCCTTAT

TATGATACAC GCTATTCCCG TGTCAACAAA CGCCTGTCGG ATTATCCTGA ATTTCAAGCA

ACCAACACGC GTACAGACGA TACGTTAGTC ACCGTTGTTA ATGGTATTAC TTATGTAGAA

AAACAAATGC GTGACGAAAA TCGTGTTACA GGTAATTTTT ATACGGTACG CGGTTCATCA

ACTTCTGCGC GTGAAGGATT AATGCCTTTA GCAGCAGAGA TGGACACTTG GCTAAAAGAG

CCATCGAAAG AAACGTATAT CGGTTACGCA GAAGATTTAG GCAATGGCCT AATCGCTCGA

CTTCAAGTGA TAACAGAAGA GCAGAAAATA AAACATGTCA GCTATGATGA ATACTTTTCA

GATGAACAGG AAAAAATCAC AGAAACAGCC TGCGGCCTTT TTATCGTCAA TCGAAATATT

ATTCACCAGG ATACAATAAA CAAACCAACA ATTCTTTTAT TCATTTTG

EF025-4 (SEQ ID NO:96)

TKQTT SGPQETKQVK QVTVTNQTTS AVEKQAPTKN

DELIANQLTF DSHEYTYEVV TGATQTTFGT TPPAKYTPEE KKKKNFWSNQ PPLGLMTGNY

YKNEGVFTGG NYGIVEITTE PETQRILNVE FTEFASDPYY DTRYSGVNKP LSDYPEFQAS

NTRTDDTLVT VVNGITYVEK QMRDENRVTG NFYTVRGSST SAREGLMPLA AEMDTWLKEP

SKETYTGYAE DLGNGLIARL QVITEEQKIK HVSYDEYFSD EQEKITETAC GLFTVNRNII

HQDTINKPTI LLFIL

EF026-1 (SEQ ID NO:97)

TGAGTGTATG ATTACTCATT TCCCTTTGAA TCAGTTATGA TAAAGGAAGA AATAAATAAA

TTTTTTGGAG GGATTTTCAT GAAAATGTCT AAAGTACTCA CCACTGTTTT GACGGCAACT

GCTGCTCTTG TGTTGCTTAG TGCTTGTTCA TCTGATAAAA AAACAGATAG TAGTTCTAGT

AGCAAAGAAA CAGCTAATTC AAGTACAGAA GTAGTCTCTG CTCCTTCAAT TAGTGCCAAG

CCTGAAGAGC TCGAAATGGC GTTAAGTGAT AAAGGAAATT GGATTGTCGC AGCTACTGAC

AATGTCACTT TTGATAAAGA GGTAACAGTT GCTGGTACTT TCCATGATAA GGGGAAAGAT

TCCAACGATG TCTATCGTAA ATTAGCACTT TATTCCCAAG ATGATAATAA AAAAGTAACT

GCTGAATATG AAATCACGGT TCCTAAGCTA ATCGTTTCTT CTGAAAATTT CAACATCGTT

CACGGGACTG TCAAAGGTGA TATTGAGGTG AAAGCAAATG GCTTTACTTT AAATGGTACC

AAAGTTAATG GCAATATTAC TTTTGATAAA CAAGAATACA AAGATTCTGC TGACTTAGAA

AAAGATGGTG CCACTGTTAC TGGTGAAGTC ACCGTAGCCA ATAATTAA

EF026-2 (SEQ ID NO:98)

MKMSK VLTTVLTATA ALVLLSACSS DKKTDSSSSS

KETANSSTEV VSGASISAKP EELEMALSDK GNWIVAATDN VTFDKEVTVA GTFHDKGKDS

NDVYRKLALY SQDDNKKVTA EYEITVPKLI VSSENFNIVH GTVKGDIEVK ANGFTLNGTK

VNGNITFDKQ EYKDSADLEK DGATVTGEVT VANN

EF026-3 (SEQ ID NO:99)

AACAGATAG TAGTTCTAGT

AGCAAAGAAA CAGCTAATTC AAGTACAGAA GTAGTCTCTG GTGCTTCAAT TAGTGCCAAG

CCTGAAGAGC TCGAAATGGC GTTAAGTGAT AAAGGAAATT GGATTGTCGC AGCTACTGAC

AATGTCACTT TTGATAAAGA GGTAACAGTT GCTGGTACTT TCCATGATAA GGGGAAAGAT

TCCAACGATG TCTATCGTAA ATTAGCACTT TATTCCCAAG ATGATAATAA AAAAGTAACT

GCTGAATATG AAATCACGGT TCCTAAGCTA ATCGTTTCTT CTGAAAATTT CAACATCGTT

CACGGGACTG TCAAAGGTGA TATTGAGGTG AAAGCAAATG GCTTTACTTT AAATGGTACC

AAAGTTAATG GCAATATTAC TTTTGATAAA CAAGAATACA AAGATTCTGC TGACTTAGAA

AAAGATGGTG CCACTGTTAC TGGTGAAGTC ACCGTAGCCA ATAAT

EF026-4 (SEQ ID NO:100)

TDSSSSS

KETANSSTEV VSGASISAKP EELEMALSDK GNWIVAATDN VTFDKEVTVA GTFHDKGKDS

NDVYRKLALY SQDDNKKVTA EYEITVPKLI VSSENFNIVH GTVKGDIEVK ANGFTLNGTK

VNGNITFDKQ EYKDSADLEK DGATVTCEVT VANN

EF027-1 (SEQ ID NO:101)

TTTGGTATGA AACAGAAAAA GTGGTTAATC GGACTTGTTG CACTGGGCTT GGTTTTAGCA

GCATGTGGAA GTGGCGGTTC GAAAACGACC TCAAACGAAC CAGCTACACA GAAAATTAAC

GTCGCATCTG GTGGTGAACT CTCGACATTA GACAGCGCTC ATTATACAGA TGTCTATAGT

TCCGATATGA TTGGTCAAGT AGTTGAAGGC TTGTATCGAC AAGATAAAAA CGGAGATCCT

GAGCTAGCTA TGGCGAAAGC AGAGCCACAA GTTAGTGAAG ACGGGTTAGT CTATACATTC

AAGTTACGAG AAGCAAAATG GACAAACGGG GATCCAGTTA AAGCAGGGGA TTTTGTAGTT

GCGTTTAGAA ACGTGGTCGA TCCAGCATAC GGTTCAAGTA GCAGTAATCA AATGGATATT

TTTAAAAATG GGCGTGCGGT GCGGGAAGGA CAAGCCACGA TGGAAGAATT TGGTGTCAAA

GCAATCGATG ACCAGACACT AGAACTAACA TTGGAAAATC CAATTCCTTA TTTAGCCCAA

GTCTTGGTTG GGACACCTTT TATGCCTAAA AATGAAGCCT TTGCCAAAGA AAAAGGTACT

GCCTATGGGA CTTCTGCAGA TAATTTTGTT GGCAATGGGC CGTTTGTAAT TTCAGGTTGG

GATGGCAATT CCGAAACTTG GAAATTGAAG AAGAATGATC ATTATTGGGA TAAAGAACAC

GTAAAATTGA ATGAAATTGA TGTTCAAGTA GTGAAAGAAA TTGGCACAGG AGCCAATCTT

TTTGATAATG GCGACTTAGA TTACACTGTT TTAGCAGATA CTTATGCACT TCAGTATAAA

GAGTCAAAAC AAGCGCATTT TGTACCTAAA GCCATGGTGG GTTATTTAAG CCCCAATCAT

CGCCGTGAAA TTACCGGCAA CGAACATGTT CGAAAAGCTT TTTTACAAGC GATTGACAAA

GAAACTTTTG CAAAAGAAAT TTTAGGAGAT GGCTCGACAG CTTTAAATGG NTTTGTACCA

GCTAATTTTG CAAAAATCCA GATACAGGTG AAGATTTCCG CAAAGAAAAT GGTGATTTAT

TGCCATATAA TATTAAAGAA GCCCAAGCTA ACTGGAACAA TT

EF027-2 (SEQ ID NO:102)

MKQKKWLI GLVALGLVLA ACGSGGSKTT SNEPATQKIN VASGGELSTL DSAHYTDVYS

SDMIGQVVEG LYRQDKNGDP ELAMAKAEPQ VSEDGLVYTF KLREAKWTNG DPVKAGDFVV

AFRNVVDPAY GSSSSNQMDI FKNGRAVREG QATMEEFGVK AIDDQTLELT LENPIPYLAQ

VLVGTPFMPK NEAFAKEKGT AYGTSADNFV GNGPFVISGW DGNSETWKLK KNDHYWDKEH

VKLNEIDVQV VKEIGTGANL FDNGDLDYTV LADTYALQYK ESKQAHFVPK AMVGYLSPNH

RREITGNEHV RKAFLQAIDK ETFAKEILGD GSTALNGFVP ANFAKIQIQV KISAKKNVIY

CHIILKKPKL TCTI

EF027-3 (SEQ ID NO:103)

AACGACC TCAAACGAAC CAGCTACACA GAAAATTAAC

GTCGCATCTG GTGGTGAACT CTCGACATTA GACAGCGCTC ATTATACAGA TGTCTATAGT

TCCGATATGA TTGGTCAAGT AGTTGAAGGC TTGTATCGAC AAGATAAAAA CGGAGATCCT

GAGCTAGCTA TGGCGAAAGC AGAGCCACAA GTTAGTGAAG ACGGGTTAGT CTATACATTC

AAGTTACGAG AACCAAAATG GACAAACGGG GATCCAGTTA AAGCAGGGGA TTTTGTAGTT

GCGTTTAGAA ACGTGGTCGA TCCAGCATAC GGTTCAAGTA GCAGTAATCA AATGGATATT

TTTAAAAATG GGCGTGCGGT GCGGGAAGGA CAAGCCACGA TGGAAGAATT TGGTGTCAAA

GCAATCGATG ACCAGACACT AGAACTAACA TTGGAAAATC CAATTCCTTA TTTAGCCCAA

GTCTTGGTTG GGACACCTTT TATGCCTAAA AATGAAGCCT TTGCCAAAGA AAAAGGTACT

GCCTATGGGA CTTCTGCAGA TAATTTTGTT GGCAATGGGC CGTTTCTAAT TTCAGGTTGG

GATGGCAATT CCGAAACTTG GAAATTGAAG AAGAATGATC ATTATTGGGA TAAAGAACAC

GTAAAATTGA ATGAAATTGA TGTTCAAGTA GTGAAAGAAA TTGGCACAGG AGCCAATCTT

TTTGATAATG GCGACTTAGA TTACACTGTT TTAGCAGATA CTTATGCACT TCAGTATAAA

GAGTCAAAAC AAGCGCATTT TGTACCTAAA GCCATGGTGG GTTATTTAAG CCCCAATCAT

CGCCGTGAAA TTACCGGCAA CGAACATGTT CGAAAAGCTT TTTTACAAGC GATTGACAAA

GAAACTTTTG CAAAAGAAAT TTTAGGAGAT GGCTCGACAG CTTTAAATGG NTTTGTACCA

GCTAATTTTG CAAAAATCCA GATACAGGTG AAGATTTCCG CAAAGAAAAT GGTGATTTAT

TGCCATATAA TATTAAAGAA GCCCAAGCTA A

EF027-4 (SEQ ID NO:104)

TT SNEPATQKIN VASGGELSTL DSAHYTDVYS

SDMIGQVVEG LYRQDKNGDP ELANAKAEPQ VSEDGLVYTF KLREAKWTNG DPVKAGDFVV

AFRNVVDPAY GSSSSNQMDI FKNGRAVREG QATMEEFGVK AIDDQTLELT LENPIPYLAQ

VLVGTPFMPK NEAFAKEKGT AYGTSADNFV GNGPFVISGW DGNSETWKLK KNDHYWDKEH

VKLNEIDVQV VKEIGTGANL FDNGDLDYTV LADTYALQYK ESKQAHFVPK AMVGYLSPNH

RREITGNEHV RKAFLQAIDK ETFAKEILGD GSTALNGFVP ANFAKIQTQV KISAKKMVIY

CHIILKKPKL

EF028-1 (SEQ ID NO:105)

TAACAGAAGC AATACAACAA CTTAACACTT TGTTTACTTG TTATTTATCA GAAATCAACT

AAGACTTGTT ATAGTCAATG TATGGGTAGA TATGAAGGAG GAAACAAGGA AATGAAGAAA

AGAGCTTTGC TAGGGGTTAC CTTATTAACA TTCACAACAT TAGCGGGTTG TACAAATTTA

TCTGAACAGA AAAGCGGCGA AAAACAAACA GAGGTTGCTG AAGCGAAGGC AACTGAATCT

GAAAAAGCAT CAGTAAAAAA TGTTATTTTT ATGATTGGAG ATGCCATGGG GAATCCGTAT

ACAACGGGCT ATCGCTATTT CAAAGCCAAT CACTCAGACA AGCGTGTTCC CCAAACAGCT

TTTGATACCT ATTTGGTCGG ACAGCAAGCC ACTTATCCAG AAGATGAAGA AGAGAATGTC

ACCGATTCAG CTTCCGCAGC GACAGCGATG GCTGCCGGAG TGAAAACCTA TAATAATGCT

ATTGCACTCG ATAATGACAA GTCCAAAACA GAAACAGTGC TCGAACGTGC GAAAAAAGTG

GGGAAATCAA CGGGTCTTGT AGCAACATCT GAAATAACAC ATGCAACCCC TGCTGCATAT

GGCGCACATA ATGTTTCACG CAAAAATATG GCAGAAATCG CCGATGACTA TTTTGATGAT

CAAATCGACG CACAACACAA AGTCGATGTG TTACTTGGCG GCGGCTCCGA ATTATTTGCC

CGGAAAGATC GTGATTTAGT CAAAGAATTT TCCCAAGCGG GTTATGGTCA TGTCACAGAC

AAAAACTCGT TAAATGAGAA CCAAGACGAC AAAATTTTAG GCTTGTTTGC ACCAGGCGGG

CTACCTAAAA TGATTGACCG AACGGAAGAA GTCCCTTCAT TAGCTGATAT GACAGAAGCG

GCTCTTCAAC GGTTAGATAA AAATGAAAAA GGTTTCTTTT TAATGGTTGA AGGTAGTCAA

ATTGATTGGG CCGGGCATAG CAATGATATT GTTGGCGCGA TGAGCGAAAT GCAAGACTTC

GAAGCGGCGT TTCAAAAGGC CATCGATTTT GCCAAAAAAG ATGGTGAACA TTGGTGGTTA

CAACTGCAGA TCATTCAACA GGGGGCTTGT CTTTAG

EF028-2 (SEQ ID NO:106)

MKKR ALLGVTLLTF TTLAGCTNLS

EQKSGEKQTE VAEAKATESE KASVKNVIFM IGDGMGNPYT TGYRYFKANH SDKRVPQTAF

DTYLVCQQAT YPEDEEENVT DSASAATAMA AGVKTYNNAI ALDNDKSKTE TVLERAKKVG

KSTGLVATSE ITHATPAAYG AHNVSRKNNA EIADDYFDDQ IDGQHKVDVL LGGGSELFAR

KDRDLVKEFS QAGYGHVTDK KSLNENQDDK ILGLFAPGGL PKNIDRTEEV PSLADMTEAA

LQRLDKNEKG FFLMVEGSQI DWAGHSNDIV GAMSEMQDFE AAFEKAIDFA KKDGEHWWLQ

LQTTQQGACL

EF028-3 (SEQ ID NO:107)

ACAGA AAAGCGGCGA AAAACAAACA GAGGTTGCTG AAGCGAAGGC AACTGAATCT

GAAAAAGCAT CAGTAAAAAA TGTTATTTTT ATGATTGGAG ATGGCATGGG GAATCCGTAT

ACAACGGGCT ATCGCTATTT CAAAGCCAAT CACTCAGACA AGCGTGTTCC CCAAACAGCT

TTTGATACCT ATTTGGTCGG ACAGCAAGCC ACTTATCCAG AAGATGAAGA AGAGAATGTC

ACCGATTCAG CTTCCGCAGC GACAGCGATG GCTGCCGGAG TGAAAACCTA TAATAATGCT

ATTGCACTCG ATAATGACAA GTCCAAAACA GAAACAGTGC TCGAACGTGC GAAAAAAGTG

GGGAAATCAA CGGGTCTTGT AGCAACATCT GAAATAACAC ATGCAACCCC TGCTGCATAT

GGCGCACATA ATGTTTCACG CAAAAATATG GCAGAAATCG CCGATGACTA TTTTGATGAT

CAAATCGACG GACAACACAA AGTCGATGTG TTACTTGGCG GCGGCTCCGA ATTATTTGCC

CGGAAAGATC GTGATTTAGT CAAAGAATTT TCCCAAGCGG GTTATGGTCA TGTCACAGAC

AAAAAGTCGT TAAATGAGAA CCAAGACGAC AAAATTTTAG GCTTGTTTGC ACCAGGCGGG

CTACCTAAAA TGATTGACCG AACGGAAGAA GTCCCTTCAT TAGCTGATAT GACAGAAGCG

GCTCTTCAAC GGTTAGATAA AAATGAAAAA GGTTTCTTTT TAATGGTTGA AGGTAGTCAA

ATTGATTGGG CCGGGCATAG CAATGATATT GTTGGCGCGA TGAGCGAAAT GCAAGACTTC

GAAGCGGCGT TTGAAAAGGC CATCGATTTT GCCAAAAAAG ATGGTGAACA TTGGTGGTTA

CAACTGCAGA TCATTCAACA GGGGGCTTGT CTT

EF028-4 (SEQ ID NO:108)

QKSGEKQTE VAEAKATESE KASVKNVIFM IGDGMGNPYT TGYRYFKANH SDKRVPQTAF

DTYLVGQQAT YPEDEEENVT DSASAATAMA AGVKTYNNAT ALDNDKSKTE TVLERAKKVG

KSTGLVATSE ITHATPAAYG AHNVSRKNMA EIADDYFDDQ IDGQHKVDVL LGGGSELFAR

KDRDLVKEFS QAGYGHVTDK KSLNENQDDK ILGLFAPGGL PKMIDRTEEV PSLADMTEAA

LQRLDKNEKG FFLMVEGSQI DWAGHSNDIV GAMSEMQDPE AAFEKAIDFA KKDGEHWWLQ

LQI IQQGACL

EF029-1 (SEQ ID NO:109)

TGAAGGAGGG AGAAAATGAA AAAGTTAATC GGTAAAAAGT GGCTGCTGCT TACAGCAGTA

GCCACTTTTT TATTATCAGG ATGCGCAAGT CTTGAACAAA AAGCACAGGA TAGTGTAAAA

GAAGTTACTG AAAATGTTAC TCAAACTATT TCAAACGATC AACGTATACC AGCTGATTTT

GTTAGGCACG TGGATGGCGA TACCACAGTA TTAAAAATTG ACGGAAAAGA ACAAAAACTT

CGGTTTTTAT TAATTGACAC ACCCGAGACT GTGAAACCGA AAACAAAAGT TCAGCCGTTC

GGATTGGAAG CTAGCAAACG CACAAAAGAG CTTTTGTCTA CTGCTTCAGA AATTACGTTT

GAATATGATA AGGGCGATAA AACAGATCGT TACGGACGAG CGTTGGGCTA CATATTCGTA

GATGGAACAT TACTACAAAA AACGCTTGTA AGTCAAGGAT TAGCTCGTGT TGCCTATGTA

AAAGACCCTA CAACTAAGTA TTTGGCAGAA CTAGAGCAAG CCCAAGAACA GGCTAAAAAT

GAGTCACTCG GAATCTGGAG CATACCAGGT TATGTGACAC AACGGGGGTT TAGTAAATAA

EF029-2 (SEQ ID NO:110)

MKKLIG KKWLLLTAVA TFLLSGCASL EQKAQDSVKE VTENVTQTIS NDQRIPADFV

RHVDGDTTVL KIDGKEQKVR FLLIDTPETV KPKTKVQPFG LEASKRTKEL LSTASEITFE

YDKGDKTDRY GRALGYIFVD GTLLQKTLVS EGLARVAYVK EPTTKYLAEL EQAQEQAKNE

SLGIWSIPGY VTQRGFSK

EF029-3 (SEQ ID NO:111)

AAATGTTAC TCAAACTATT TCAAACGATC AACGTATACC AGCTGATTTT

GTTAGGCACG TGGATGGCGA TACCACAGTA TTAAAAATTG ACGGAAAAGA ACAAAAAGTT

CGGTTTTTAT TAATTGACAC ACCCGAGACT GTCAAACCGA AAACAAAAGT TCAGCCGTTC

GGATTGGAAG CTAGCAAACG CACAAAAGAG CTTTTGTCTA CTGCTTCAGA AATTACGTTT

GAATATGATA AGGGCGATAA AACAGATCGT TACGGACGAG CGTTGGGCTA CATATTCGTA

GATGGAACAT TACTACAAAA AACGCTTGTA AGTGAACGAT TAGCTCGTCT TGCCTATGTA

AAAGAGCCTA CAACTAAGTA TTTGGCAGAA CTAGAGCAAG CCCAAGAACA GGCTAAAAAT

GAGTCACTCG GAATCTGGAG CATACCAGGT TATGTGACAC AACGCGGGTT TAGTAAA

EF029-4 (SEQ ID NO:112)

NVTQTIS NDQRIPADFV

RHVDGDTTVL KIDGKEQKVR FLLTDTPETV KPKTKVQPFG LEASKRTKEL LSTASEITFE

YDKGDKTDRY GRALGYIFVD GTLLQKTLVS EGLARVAYVK EPTTKYLAEL EQAQEQAKNE

SLGIWSIPGY VTQRGFSK

EF030-1 (SEQ ID NO:113)

TGATTGACAC ATAGGGGGAA TAGTATGAAA AAGTTAAAAA TGATGGGGAT TATGTTATTT

GTTAGTACGG TCTTGGTAGG TTGTGGCACA ACAGCAGANA CAAAAATAGA CGAGAAAGCA

ACTGAGAAAA CCAGTGTCTC GAAAAAAGTT TTAAATTTAA TGGAGAACTC GGAAATCGGT

TCAATGGATT CTATTTTTAC ACAAGATGAA GCCAGTATTA ACGCACAGTC CAATGTCTTT

GAAGGGTTAT ATCAATTGGA TGAAAAAGAT CAACTAATAC CTGCTGCTGC TAAAGAGATG

CCAGAAATTT CTGAGGATGG CAAACGATAT ACCATTAAAC TAAGAGAAGA TCGCAAGTGG

TCCAATGGTG ATGCTGTAAC AGCCAATGAT TTCGTTTTTG CTTGGCGTAA ATTAGCGAAT

CCCAAAAACC AAGCCAATTA CTTTTTCTTG TTAGAAGGAA CGATTCTGAA CGGAACAGCT

ATTACAAAAG AGGAAAAAGC ACCAGAGGAA TTGGGTGTCA AAGCGCTTGA TGATTATACT

TTGGAGGTTA CTTTAGAAAA GCCTGTACCA TATTTTACGT CGTTATTGGC ATTTTCTCCA

TTTTTCCCAC AAAACGAAGC ATTCGTGAAA GAAAAAGGAC AAGCCTATGG CACTTCTAGT

GAAATGATTG TATCTAATGG TCCGTTTTTA ATGAAAAATT GGGATCAGTC AGCGATGTCG

TGGGATTTTG TGCGTAATCC CTACTATTAC GATAAACAAA AAGTAAAATC AGAAACGATT

CATTTTGAAG TTCTTAAAGA AACCAATACC GTTTATAATT TGTACGAATC AGGTGAATTA

GATGTGGCTG TCTTAACAGG AGATTTTGCT AAACAAAATC GAGACAACCC AGACTATGAA

GCAATCGAAC GGTCAAAAGT CTATTCCTTA CGTTTAAACC AAAAAAGAAA CGAAAAACCA

TCCATTTTTG CAAATGAGAA TGTCCGCAAA GCTTTAGCTT ATGCTTTGGA TAAAAAAAGT

TTAGTCGATA ATATTTTAGC AGATGGCTCA AAAGAAATTT ATGGGTACAT TCCAGAAAAA

TTTGTATATA ACCCAGAAAC GAATGAAGAT TTTCGTCAAG AAGCAGGCGC TCTTGTCAAA

ACAGACGCCA AAAAAGCCAA AGAGTATTTA GATAAAGCAA AAGCAGAGCT AAACGGAGAT

GTAGCCATTG AACTTCTTTC AAGAGATGGT GATAGTGACC GA

EF030-2 (SEQ ID NO:114)

MKK LKMMGIMLFV STVLVGCGTT AXTKIDEKAT EKTSVSKKVL NLMENSEIGS

MDSIFTQDEA SINAQSNVFE GLYQLDEKDQ LIPAAAKEMP EISEDGKRYT IKLREDGKWS

NGDAVTANDF VFAWRKLANP KNQANYFFLL EGTILNGTAI TKEEKAPEEL GVKALDDYTL

EVTLEKPVPY FTSLLAFSPF FPQNEAFVKE KGQAYGTSSE MIVSNGPFLM KNWDQSAMSW

DFVRNPYYYD KEKVKSETIH FEVLKETNTV YNLYESGELD VAVLTGDFAK QNRDNPDYEA

IERSKVYSLR LNQKRNEKPS IFANENVRKA LAYALDKKSL VDNILADGSK EIYGYIPEKF

VYNPETNEDF RQEAGALVKT DAKKAKEYLD KAKAELNGDV AIELLSRDGD SDR

EF030-3 (SEQ ID NO:115)

GAGAAAGCA

ACTGAGAAAA CCAGTGTCTC GAAAAAAGTT TTAAATTTAA TGGAGAACTC GGAAATCGGT

TCAATGGATT CTATTTTTAC ACAAGATCAA GCCAGTATTA ACGCACAGTC CAATGTCTTT

GAAGGGTTAT ATCAATTGGA TGAAAAAGAT CAACTAATAC CTGCTGCTGC TAAAGAGATG

CCACAAATTT CTGAGGATGG CAAACGATAT ACCATTAAAC TAAGAGAAGA TCCCAAGTGG

TCCAATGGTG ATGCTGTAAC AGCCAATGAT TTCGTTTTTG CTTGGCGTAA ATTAGCGAAT

CCCAAAAACC AAGCCAATTA CTTTTTCTTG TTAGAAGGAA CGATTCTGAA CGGAACACCT

ATTACAAAAC AGGAAAAAGC ACCACACGAA TTGGGTGTCA AAGCGCTTGA TOATTATACT

TTGGAGGTTA CTTTAGAAAA GCCTGTACCA TATTTTACGT CGTTATTGGC ATTTTCTCCA

TTTTTCCCAC AAAACGAAGC ATTCGTGAAA GAAAAAGGAC AACCCTATGG CACTTCTAGT

GAAATCATTG TATCTAATGG TCCCTTTTTA ATGAAAAATT GGGATCAGTC AGCGATGTCG

TGGGATTTTC TCCGTAATCC CTACTATTAC CATAAAGAAA AACTAAAATC AGAAACGATT

CATTTTGAAG TTCTTAAAGA AACCAATACC GTTTATAATT TGTACGAATC AGGTGAATTA

GATGTGGCTG TCTTAACAGG AGATTTTGCT AAACAAAATC GAGACAACCC AGACTATGAA

GCAATCCAAC CGTCAAAAGT CTATTCCTTA CGTTTAAACC AAAAAAGAAA CGAAAAACCA

TCCATTTTTG CAAATGAGAA TGTCCGCAAA CCTTTAGCTT ATGCTTTGGA TAAAAAAACT

TTACTCGATA ATATTTTACC AGATGGCTCA AAAGAAATTT ATOGOTACAT TCCAGAAAAA

TTTGTATATA ACCCAGAAAC GAATGAAGAT TTTCGTCAAG AAGCAGGCGC TCTTGTCAAA

ACAGACGCCA AAAAAGCCAA AGAGTATTTA GATAAAGCAA AAGCAGAGCT AAACGGAGAT

GTAGCCATTG AACTTCTTTC AAGAGATGGT

EF030-4 (SEQ ID NO:116)

EKAT EKTSVSKKVL NLMENSETGS

MDSIFTQDEA SINAQSNVFE GLYQLDEKDQ LIPAAAKEMP EISEDGKRYT IKLREDGKWS

NGDAVTANDF VFAWRKLANP KNQANYFFLL EGTILNGTAI TKEEKAPEEL GVKALDDYTL

EVTLEKPVPY FTSLLAFSPF FPQNEAFVKE KGQAYGTSSE MIVSNGPFLM KNWDQSAMSW

DFVRNPYYYD KEKVKSETTH FEVLKETNTV YNLYESGELD VAVLTGDFAK QNRDNPDYEA

IERSKVYSLR LNQKRNEKPS IFANENVRKA LAYALDKKSL VDNILADCSK EIYGYIPEKF

VYNPETNEDE RQEAGALVKT DAKKAKEYLD KAKAELNGDV AIELLSRDG

EF031-1 (SEQ ID NO:117)

TGAGAAATTA GTTATTTTAG AAAAATAAAA ACCATTTTGG ACGAAGATTT AAAAATGAAA

AAACGCGTAA TTTTAGGGAC ATTAGTCGCT GCAACGTTAT TAATCACTGC TTGTGGAAAC

AGCGAAGCAA CTACGAAAAG CGAGAGCAAA GGTGGAAGTA ATGCTTTAGT CGTTTCAACT

TTCGGATTAA GTGAAGATAT TGTCAAAAAA GACATTATCG CTCCATTTGA AAAAGAGAAT

GAAGCGAAAG TTACCTTAGA AGTAGGCAAT ACCCCAGACC GCTTTACGAA ATTAAAAAAT

AATCCCAATG CGGGAATTGA TGTCATTGAA TTAGCACAAG CAAATGCAGC ACAAGGTGGA

AAAGATCCGT TATTTGAAAA AATTACAGAA AAAGAAGTAC CTAATTTAAG TCAGTTAACC

CCGGGAGCAA AAGAGGTTTT TGAAAGTGGT GCTGGCGTAC CAATCGCTGT AAACAGTATC

GGGATTGTTT ACAACAAAGA AAAATTAGGC AAACAAATTA AAAACTGGGA TGACTTATGG

TCAGCTGATT TGAAAGGTAA AATTTCTGTT CCACACGTTG CCACGACGGC AGGTCCTTTA

ATCTTATACG TTGCTAGTGA ACATGCTGGT CAAGATATTA CAAAAGATAA CGGGAAGGCC

GCTTTTGAAC CCATGAAAGA ATTAAAACCA AACGTTGTTA AAACGTATTC AAAATCGTCA

GACTTAGCNA ATATGTTCCA ATCTGGTGAA ATTGAAGCAG CTGTGGTTGC TGATTTTGCG

GTTGATATTA TTCAAGGCGC ACAGAAAACG TGA

EF0031-2 (SEQ ID NO:118)

MKK RVTLGTLVAA TLLMTACGNS EATTKSESKG GSNALVVSTF

GLSEDIVKKD IIAPFEKENE AKVTLEVGNS ADRFTKLKNN PNAGIDVIEL AQANAAQGCK

DGLFEKITEK EVPNLSQLTP GAKEVFESGA GVPTAVNSIG IVYNKEKLCK ETKNWDDLWS

ADLKGKISVP DVATTACPLM LYVASEHACQ DITKDNCKAA FEAMKELKPN VVKTYSKSSD

LANMFQSGEI EAAVVADFAV DIIQGAQKT

EF031-3 (SEQ ID NO:119)

AA CTACGAAAAG CGAGAGCAAA GGTC-GAAGTA ATGCTTTAGT CGTTTCAACT

TTCGGATTAA GTGAAGATAT TGTCAAAAAA GACATTATCG CTCCATTTGA AAAAGAGAAT

GAAGCGAAAG TTACCTTAGA AGTAGGCAAT AGCGCAGACC GCTTTACGAA ATTAAAAAAT

AATCCCAATG CGGGAATTGA TGTCATTGAA TTAGCACAAG CAAATGCAGC ACAAGGTGGA

AAAGATGGGT TATTTGAAAA AATTACACAA AAAGAAGTAC CTAATTTAAG TCAGTTAACG

CCGGGAGCAA AAGAGGTTTT TGAAAGTGGT GCTGGCGTAC CAATCGCTGT AAACAGTATC

GGGATTGTTT ACAACAAAGA AAAATTAGGC AAAGAAATTA AAAACTGGGA TGACTTATGG

TCAGCTGATT TGAAAGGTAA AATTTCTGTT CCAGACGTTG CCACGACGGC AGGTCCTTTA

ATGTTATACG TTGCTAGTGA ACATGCTGGT CAAGATATTA CAAAAGATAA CGGGAAGGCC

CCTTTTGAAG CGATGAAAGA ATTAAAACCA AACGTTGTTA AAACGTATTC AAAATCGTCA

GACTTAGCNA ATATGTTCCA ATCTGGTGAA ATTGAAGCAG CTGTGGTTGC TGATTTTGCC

GTTGATATTA TTCAAGGCGC ACAGAAAA

EF031-4 (SEQ ID NO:120)

TTKSESKG GSNALVVSTF

GLSEDIVKKD IIAPFEKENE AKVTLEVGNS ADRFTKLKNN PNAGIDVIEL AQANAAQGCK

DGLFEKTTEK EVPNLSQLTP GAKEVFESGA GVPIAVNSIG IVYNKEKLGK EIKNWDDLWS

ADLKGKISVP DVATTAGPLM LYVASEHAGQ DITKDNGKAA FEAMKELKPN VVKTYSKSSD

LANMFQSGEI EAAVVADFAV DIIQGAQK

EF032-1 (SEQ ID NO:121)

TGAATAAATT ATTTAGGAGG AATTATGATG AAAAAATTAA TTAGTTTAGG ATTGGTTTGT

GTTTGTGGTA TTTCACTACT TACTGCTTGT NCGGGAAATA ATGATAATAA AGATACTGAA

AAGTCAACCA GTCAATCTAG CAGCACAGTT AAACAACCGA ATTCAAAAGA CTTTGTTGCG

TCAGGGGAAT ATTCAGTTGG AAAAGATATT GATCCTGGAG ATTACTATGC TGTATTAACT

CAACTAGATG ATAAATCGAG CATAGTTCTT ATTACCGTCA AATCAGGCGG AGAAAATAGT

AACCATGACT TATACGGAGT GGGAAACAAG AAAAAAGTAT CTCTTAAAAA GGGAGATACT

CTCACATTCG AAACTGCCGA CAAAGATTTT GTTGTTAGAT TTTTAAATGA AAAAGATTTT

CAAGAATATA TGAAAAATCC AGTATCNAGT ACTGAAACTA GCAAACANAA AACAGTAAAC

TCTGATGTTT CTAAAAGTAG TAGCCAAGAT AATAAACAAT CTGATGTATC TGAAAAAAAA

GAAGTAAGTA CTGAAGCGAA GTCTGATGTA GCTACTAATA CTTTACCGAG CGAAGATAAA

AATACTAATC ACATTACTAA GCTAGCACAT GAGCCAACCT TAGAACAACA AACCGTCTTA

GATACTTTAG CTAAGCATCA ATTTAATGAT ATGTATCCTT ATAAAGGAAG CAAAATGCAT

TCAATTATCG GCGTCATCCC AACCATGGAC GCAAAAAGAT GGTAA

EF032-2 (SEQ ID NO:122)

MK KLISLGLVCV CGISLLTACX GNNDNKDTEK STSQSSSTVK QPNSKDFVAS

GEYSVGKDID PGDYYAVLTQ LDDKSSIVLI TVKSGGENSN HDLYGVGNKK KVSLKKGDTL

TFETADKDFV VRFLNEKDFQ EYMKNPVSST ETSKXKTVNS DVSKSSSQDN KQSDVSEKKE

VSTEAKSDVA TNTLPSEDKN TNDITKLADE PTLEQQTVLD TLAKHQFNDM YPYKGSKMHS

IIGVIPTMDA KRW

EF032-3 (SEQ ID NO:123)

TA ATGATAATAA AGATACTGAA

AAGTCAACCA GTCAATCTAG CAGCACAGTT AAACAACCGA ATTCAAAAGA CTTTGTTGCG

TCAGGGGAAT ATTCAGTTGG AAAAGATATT GATCCTGGAG ATTACTATGC TGTATTAACT

CAACTAGATG ATAAATCGAG CATAGTTCTT ATTACCGTCA AATCAGGCGG AGAAAATAGT

AACCATGACT TATACGGAGT GGGAAACAAG AAAAAAGTAT CTCTTAAAAA GGGAGATACT

CTCACATTCG AAACTGCCGA CAAAGATTTT GTTGTTAGAT TTTTAAATGA AAAAGATTTT

CAAGAATATA TGAAAAATCC AGTATCNAGT ACTGAAACTA GCAAACANAA AACAGTAAAC

TCTGATGTTT CTAAAAGTAG TAGCCAAGAT AATAAACAAT CTGATGTATC TGAAAAAAAA

CAAGTAAGTA CTGAAGCGAA GTCTGATGTA GCTACTAATA CTTTACCGAG CGAAGATAAA

AATACTAATG ACATTACTAA GCTAGCAGAT GAGCCAACCT TAGAACAACA AACCGTCTTA

GATACTTTAG CTAAGCATCA ATTTAATGAT ATGTATCCTT ATAAAGGAAG CAAAATGCAT

TCAATTATCG CCGTCATCCC AACCATGGAC GCAAAAAGAT GG

EF032-4 (SEQ ID NO:124)

NDNKDTEK STSQSSSTVK QPNSKDFVAS

GEYSVCKDID PGDYYAVLTQ LDDKSSIVLI TVKSGGENSN HDLYGVGNKK KVSLKKGDTL

TFETADKDFV VRFLNEKDFQ EYMKNPVSST ETSKXKTVNS DVSKSSSQDN KQSDVSEKKE

VSTEAKSDVA TNTLPSEDKN TNDITKLADE PTLEQQTVLD TLAKHQFNDM YPYKGSKMHS

IIGVIPTMDA KRW

EF033-1 (SEQ ID NO:125)

TCACTGCTTT TTTTCTATTG GAGAAAAAAG TGGTTTTTTT GTATTGTTTT GACGTTGAGA

CAAAGGAGGT TCATTTCAGA AAATTTTCCC CAAAATAAAA TAGACGAATG CGAGGATGAA

AAAATGAAAA AATTTACTTT AACAATGATC ACTTTAGGTT TAGTAGCAAC ACTTGGCTTA

GCAGGATGTG GTAAACAGGA AAAGAAAGCA ACTACCTCTT CTGAAAAAAC AGAAGTAACG

TTACCAACCA AAGACCGTAG CGGCAAAGAA ATTACTTTAC CCAAAGAACC AACCAAAATT

ATTTCCCTAG TGCCATCAAC AACAGAAGTG ATTGAAGACT TAGGTAAAAC CGACCAATTA

ATCGCAGTTG ATACTCAAAG TAGTACAATG ATGACTGATT TAAAAAAATT ACCACAAATG

GATATGATGG CTGTCGATGC CGAAAAATTG ATTGCCTTGA AACCACAAAT TGTTTATGTG

AATGACATCA ATTTAGCTAG CTCAGAAAGT GTTTGGAAGC AAGTGGAAGA TGCTGGAATT

ACAGTCCTTA ATATCCCCAC TAGTACAAGC ATCAAAGCAA TCAAAGAACA CGTCCAATTC

ATCGCTGATA GCTTATCTGA ACATGAAAAA GGACAAAAGT TAATCAAAAC AATGGATCAA

GAAATCGACG AGTAG

EF033-2 (SEQ ID NO:126)

MKKFTLTMMT LGLVATLGLA

GCGKQEKKAT TSSEKTEVTL PTKDRSGKEI TLPKEATKII SLVPSTTEVI EDLGKTDQLI

AVDTQSSTMM TDLKKLPQMD MMAVDAEKLI ALKPQIVYVN DINLASSESV WKQVEDAGIT

VVNIPTSTSI KAIKEDVQFI ADSLSEHEKG QKLIKTHDQE IDE

EF033-3 (SEQ ID NO:127)

CTCTT CTCAAAAAAC AGAAGTAACC

TTACCAACCA AAGACCGTAG CGGCAAAGAA ATTACTTTAC CCAAAGAAGC AACCAAAATT

ATTTCCCTAG TGCCATCAAC AACAGAAGTC ATTGAAGACT TAGGTAAAAC CGACCAATTA

ATCGCAGTTG ATACTCAAAG TAGTACAATG ATGACTGATT TAAAAAAATT ACCACAAATG

GATATGATGG CTGTCGATGC CCAAAAATTG ATTGCCTTGA AACCACAAAT TGTTTATGTG

AATGACATCA ATTTAGCTAG CTCAGAAAGT GTTTGGAAGC AAGTGGAAGA TGCTGGAATT

ACAGTCGTTA ATATCCCCAC TAGTACAAGC ATCAAAGCAA TCAAAGAAGA CGTCCAATTC

ATCGCTGATA GCTTATCTGA ACATGAAAAA GGACAAAAGT TAATCAAAAC AATGGATCAA

GAAATCGACG AGTAG

EF033-4 (SEQ ID NO:128)

SSEKTEVTL PTKDRSGKEI TLPKEATKII SLVPSTTEVI EDLGKTDQLT

AVDTQSSTMM TDLKKLPQMD MMAVDAEKLI ALKPQIVYVN DINLASSESV WKQVEDAGIT

VVNIPTSTSI KAIKEDVQFI ADSLSEHEKG QKLIKTMDQE IDE

EF034-1 (SEQ ID NO:129)

TACGAGGGAG TAATCATGAA AAAAATCGGG TATTTTAGTT GTATTATTTT TTTCATGTTT

TTGGTAGGTT GTAGTAATAA CAAAAAAGAA AACGGCAATC TTTTGAATGC CAGTTCCTTT

CCTTTAATAC TCACCACGAT TATTCAAAAA GAACAAGACC TAACGAAAGG TTCAATTTTT

TTCAACAAGG ATAAAACCAT GACGCTTGAA AAAGAATATT TAGTTAATCC CAATAATGAA

GACACAAAAA AAACAAGTAG AACAGAAAAA AACGTATATA AAAATATTAA AATACAAGAA

AATAAAGAGA GCTATGAAAT TATAGGTCAA TTGGACAAAA AAACGAAAAA AATAGAGTTT

AAAAAAGTTG ATGAAGGTAA ACGTATATCT GATGCAGAAG GTAATGTGTA TGGTGATTTT

GGTGGTAAAT AG

EF034-2 (SEQ ID NO:130)

MKKIGY FSCIIFFMFL VGCSNNKKEN GNLLNASSFP LILTTIIEKE EDLTKGSIFF

NKDKTMTLEK EYLVNPNNED TKKTSRTEKK VYKNIKIQEN KESYEIIGQL DKKTKKIEFK

KXTDEGKRISD AEGNVYGDFG GK

EF034-3 (SEQ ID NO:131)

AGAA AACGGCAATC TTTTGAATGC CAGTTCGTTT

CCTTTAATAC TCACCACGAT TATTCAAAAA GAAGAAGACC TAACGAAAGG TTCAATTTTT

TTCAACAAGG ATAAAACCAT GACGCTTGAA AAAGAATATT TAGTTAATCC CAATAATGAA

GACACAAAAA AAACAAGTAC AACAGAAAAA AAGGTATATA AAAATATTAA AATACAAGAA

AATAAAGAGA CCTATGAAAT TATAGGTCAA TTGGACAAAA AAACGAAAAA AATAGAGTTT

AAAAAAGTTG ATGAAGGTAA ACGTATATCT GATGCAGAAG GTAATGTGTA TGCTGATTTT

GGTGGTAAAT AC

EF034-4 (SEQ ID NO:132)

KEN GNLLNASSFP LILTTIIEKE EDLTKGSIFF

NKDKTNTLEK EYLVNPNNED TKKTSRTEKK VYKNIKIQEN KESYEIIGQL DKKTKKIEFK

KVDECKRISD AEGNVYGDFG GK

EF035-1 (SEQ ID NO:133)

TAAACGAGAG GTGAGTTTAT GAAAACAAAA ATCCGAAAAA CAGTTATCTT GTCAGCATTT

TTATTCACAA GTTTCCTTTT ACTGAGTGGT TGTACCTCGG CTGGCGAAGA GATGGAAAAA

ACAATTGATC GACAGAAAGA AAAAGTCGAT AAAACGGTCG ATAAGCAGAA ACATAAAAAT

GAAAATTCCA TGGAAAGTTA CGACGAAAAA GTTGACCGTT CTTTAGATAG TCAAGAAGAC

AAAATCC-ATA CTACTGAGTA A

EF035-2 (SEQ ID NO:134)

NKTKI GKTVILSAFL FTSFLLLSGC TSAGEEMEKT IDRQKEKVDK TVDKQKHKNE

NSMESYDEKV DRSLDSQEDK IDTTE

EF035-3 (SEQ ID NO:135)

GATGGAAAAA

ACAATTGATC GACAGAAAGA AAAAGTCGAT AAAACGGTCG ATAAGCAGAA ACATAAAAAT

GAAAATTCCA TGGAAAGTTA CGACGAAAAA GTTGACCGTT CTTTAGATAG TCAAGAAGAC

AAAATCGATA CTACTGAG

EF035-4 (SEQ ID NO:136)

MEKT IDRQKEKVDK TVDKQKHKNE

NSMESYDEKV DRSLDSQEDK IDTTE

EF036-1 (SEQ ID NO:137)

TAATTTTCAA GTCCTACATA TAATGGTAAA ATAGAATGGA TTGAAATTAA TTGGAGGAAT

AATGAATCGA TGAAAAAAAG ATTGCTATTA TTTATTGGTT TGGCAAGTAT ACTTACTTTG

ACAGGATGTG CAAAATGGAT TGATCGTGGT GAATCCATCA CAGCGGTAGG CTCATCAGCT

TTACAACCAT TAGTAGAGAC AGCGAGTGAG GAATATCAAA GCCAAAATCC GGGAAGATTT

ATTAATGTCC AAGGTGGCGG AAGCGGAACA GGTCTGAGTC AAGTCCAATC TGGCGCGGTA

GACATTGGTA ATTCTGATTT ATTTGCAGAA GAGAAAAAGG GCATCAAAGC GGAAGACTTA

ATTGATCATA AAGTTGCTGT CGTTGGGATT ACACCAATCG TTAACAAAAA TGTCGCTGTC

AAAGATATCT CAATGGAAAA TTTAAAGAAA ATCTTTTTAG GTGAAGTAAC AAACTGGAAA

GAACTTCGCG GGAAAGACCA AAAAATTGTT ATTTTGAATA GAGCCGCCGG TAGTCGTACG

CGTGCGACTT TTGAAAAGTG GGTCTTGGGA GATAAAACAG CCATTCGTGC GCAAGAACAA

GATTCCAGCG GCATGGTTCG TTCCATTGTT TCTGATACAC CAGGAGCGAT TAGTTATACC

GCATTTTCAT ATGTTACTGA TGAAGTAGCT ACGTTAAGTA TTGATGGTGT TCAGCCAACA

GATGAAAATG TAATGAACAA TAAATGGATT ATTTGGTCTT ATGAACACAT GTACACTCGT

AAAAATCCAA GTGATTTAAC CAAAGAGTTT TTAGACTTTA TGTTGTCAGA TGATATCCAA

GAACGTGTGA TTGGTCAATT AGGGTATATT CCTGTTTCGA AAATGGAAAT TGAACGGGAT

TGGCAAGGAA ATGTCATTAA ATAA

EF-36-2 (SEQ ID NO:138)

MKKRLLLF IGLASILTLT GCAKWIDRGE SITAVGSSAL

QPLVETASEE YQSQNPGRFI NVQGGGSGTG LSQVQSGAVD IGNSDLFAEE KKGIKAEDLI

DHKVAVVGIT PTVNKNVGVK DISMENLKKI FLGEVTNWKE LGGKDQKTVT LNRAAGSGTR

ATFEKWVLGD KTAIRAQEQD SSGMVRSIVS DTPGAISYTA FSYVTDEVAT LSIDGVQPTD

ENVMNNKWII WSYEHMYTRK NPSDLTKEFL DFMLSDDIQE RVIGQLGYIP VSKNEIERDW

QGNVIK

EF036-3 (SEQ ID NO:139)

GAT TGATCGTGGT GAATCCATCA CAGCGGTAGG CTCATCAGCT

TTACAACCAT TACTAGAGAC AGCGAGTGAG GAATATCAAA GCCAAAATCC GGGAAGATTT

ATTAATGTCC AAGGTGGCGG AAGCGGAACA GGTCTGAGTC AAGTCCAATC TGGCGCGGTA

GACATTGGTA ATTCTGATTT ATTTGCAGAA GAGAAAAAGG GCATCAAAGC GGAAGACTTA

ATTGATCATA AAGTTGCTGT CGTTGGGATT ACACCAATCG TTAACAAAAA TGTCGGTGTC

AAAGATATCT CAATGGAAAA TTTAAAGAAA ATCTTTTTAG GTGAAGTAAC AAACTGGAAA

GAACTTGGCG GGAAAGACCA AAAAATTGTT ATTTTGAATA GAGCGGCCGG TAGTGGTACG

CGTGCGACTT TTGAAAAGTG GGTCTTGGGA GATAAAACAG CCATTCGTGC GCAAGAACAA

GATTCCAGCG GCATGGTTCG TTCCATTGTT TCTGATACAC CAGGAGCGAT TAGTTATACC

GCATTTTCAT ATCTTACTGA TGAAGTAGCT ACGTTAAGTA TTGATCGTGT TCAGCCAACA

GATGAAAATG TAATGAACAA TAAATGGATT ATTTGGTCTT ATGAACACAT GTACACTCGT

AAAAATCCAA GTGATTTAAC CAAAGAGTTT TTAGACTTTA TGTTGTCAGA TGATATCCAA

GAACGTGTGA TTGGTCAATT AGGGTATATT CCTGTTTCGA AAATGGAAAT TGAACGGGAT

TGGCAAGGAA ATGTCATTAA A

EF036-4 (SEQ ID NO:140)

IDEGE SITAVGSSAL

QPLVETASEE YQSQNPGRFT NVQGGGSGTG LSQVQSGAVD IGNSDLFAEE KKGIKAEDLI

DHKVAVVGIT PTVNKNVGVK DISMENLKKI FLGEVTNWKE LGGKDQKTVI LNRAACSGTR

ATFEKWVLGD KTATEAQEQD SSGMVRSIVS DTPGAISYTA FSYVTDEVAT LSIDGVQPTD

ENVHNNKWTI WSYEHMYTRK NPSDLTKEFL DFMLSDDIQE RVIGQLGYIP VSKMEIERDW

QGNVIK

EF037-1 (SEQ ID NO:141)

TGAGTGTATG ATTACTCATT TCCCTTTGAA TCAGTTATGA TAAAGGAAGA AATAAATAAA

TTTTTTGGAG GGATTTTCAT GAAAATGTCT AAAGTACTCA CCACTGTTTT GACGGCAACT

GCTGCTCTTG TGTTGCTTAG TGCTTGTTCA TCTGATAAAA AAACAGATAG TAGTTCTAGT

ACCAAAGAAA CAGCTAATTC AAGTACAGAA GTAGTCTCTG GTGCTTCAAT TAGTGCCAAG

CCTGAAGAGC TCCAAATGGC GTTAAGTGAT AAAGGAAATT GGATTGTCGC AGCTACTGAC

AATGTCACTT TTGATAAAGA GGTAACAGTT GCTGGTACTT TCCATCATAA GGGGAAAGAT

TCCAACGATG TCTATCGTAA ATTAGCACTT TATTCCCAAG ATGATAATAA AAAAGTAACT

GCTGAATATG AAATCACGGT TCCTAAGCTA ATCGTTTCTT CTGAAAATTT CAACATCGTT

CACGGGACTG TCAAAGGTGA TATTGAGGTG AAAGCAAATG GCTTTACTTT AAATGGTACC

AAAGTTAATG GCAATATTAC TTTTCATAAA CAAGAATACA AAGATTCTGC TGACTTAGAA

AAAGATGGTG CCACTGTTAC TGGTCAAGTC ACCGTAGCCA ATAA

EF037-2 (SEQ ID NO:142)

MKMSK VLTTVLTATA ALVLLSACSS DKKTDSSSSS

KETANSSTEV VSGASISAKP EELEMALSDK CNWIVAATDN VTFDKEVTVA GTFHDKGKDS

NDVYRKLALY SQDDNKKVTA EYEITVPKLI VSSENFNTVH GTVKGDIEVK ANGFTLNGTK

VNGNITFDKQ EYKDSADLEK DGATVTGEVT VANN

EF037-3 (SEQ ID NO:143)

AACAGATAG TAGTTCTAGT

AGCAAAGAAA CAGCTAATTC AAGTACAGAA GTAGTCTCTG CTGCTTCAAT TAGTCCCAAG

CCTGAAGAGC TCGAAATGGC GTTAAGTGAT AAAGGAAATT GGATTGTCGC AGCTACTGAC

AATGTCACTT TTGATAAAGA GCTAACAGTT GCTGGTACTT TCCATGATAA GGGGAAAGAT

TCCAACGATG TCTATCGTAA ATTAGCACTT TATTCCCAAG ATGATAATAA AAAAGTAACT

GCTGAATATG AAATCACGGT TCCTAAGCTA ATCGTTTCTT CTGAAAATTT CAACATCGTT

CACGGGACTG TCAAAGGTGA TATTGAGGTG AAAGCAAATG GCTTTACTTT AAATGGTACC

AAACTTAATC CCAATATTAC TTTTCATAAA CAAGAATACA AAGATTCTCC TGACTTAGAA

AAAGATGGTG CCACTGTTAC TGGTGAAGTC ACCGTAGCCA A

EF037-4 (SEQ ID NO:144)

TDSSSSS

KETANSSTEV VSGASISAKP EELEMALSDK GNWIVAATDN VTFDKEVTVA GTFHDKGKDS

NDVYRKLALY SQDDNKKVTA EYEITVPKLI VSSENFNIVH GTVKGDIEVK ANGFTLNGTK

VNGNITFDKQ EYKDSADLEK DGAPVTGEVT VANN

EF038-1 (SEQ ID NO:145)

TAATGGCCAT TTCGTCTACT AATAAAGAGG ATGAAGCTAC TCAAATGGCG TTGGCAATGG

AACAAGGATC ATAAAAAAGG AGAAGTGAGC ATGAAAAAAG TACTACCTTT TATTGCCTTA

GTCGGCTTGT TATTGTTGTC AGGTTGTGGA ACAGATATGA AAAAGATATT GACTGCCGAT

GGTGGTAAAT GGGAACTAGA AAATAAAAGT CCAACTACTA CTTACACTTT TTTTGATGAT

GAAACTTTTT CGAGGTATAA TTCAAAAATT AGTGATAGTG GAACCTACTC TTACGATGAA

AATAATAAAA AACTCACTTT GGATATAAAA AATAAAGAAC AATTAATAAT GGAAAATGTT

GAATATAAAG ACGGTAAATT AAAAGGTGAA ATTGGACCCG AGAAGGACTC TGATAAAAAA

TNGAATAAGA GGTGTCTTTG A

EF038-2 (SEQ ID NO:146)

M KLLKWRWQWN KDHKKGEVSM KKVLPFIALV GLLLLSGCGT DMKKILTADG

GKWELENKSP TTTYTFFDDE TFSRYNSKIS DSGTYSYDEN NKKLTLDIKN KEQLTMENVE

YKDGKLKGEI GGEKDSDKKX NKRCL

EF038-3 (SEQ ID NO:147)

TTGTGGA ACAGATATGA AAAAGATATT GACTGCCGAT

GGTGGTAAAT GGGAACTAGA AAATAAAAGT CCAACTACTA CTTACACTTT TTTTGATGAT

GAAACTTTTT CGAGGTATAA TTCAAAAATT AGTGATAGTG GAACGTACTC TTACGATGAA

AATAATAAAA AACTCACTTT GGATATAAAA AATAAAGAAC AATTAATAAT GGAAAATGTT

CAATATAAAG ACGGTAAATT AAAAGGTGAA ATTGGAGGCG AGAAGGACTC TGATAAAAAA

TNGAATAAGA GGTGTCTTTG A

EF038-4 (SEQ ID NO:148)

CGT DMKKILTADG

GKWELENKSP TTTYTFFDDE TFSRYNSKIS DSGTYSYDEN NKKLTLDIKN KEQLIMENVE

YKDGKLKGEI GGEKDSDKKX NKRCL

EF039-l (SEQ ID NO:149)

TAAATATATC AAAAAGAAAA AAGGGGATTA CCAACCATGA AAAAGAAAAA AGTTTTTAGT

CCGCTTACCT TATTAACCTT TAGTACGTTG TTCATTGCAG GCTGTGCTGG CGGAGCCAAC

TCTGCAACAG ATAAATCAAG TGCAGCTAGC TCAAGCACTG CAGTCTCTAG TTCAGCAGAA

GCACCTAAAG AGCAATCAAA AGGACAAGAA TTAACAGAAA TTTTATCCAG TACTGATTGG

CAAGGCACAA AAGTTTACGA CAAAAATNAT AATAATTTAA CAGCAGAAAA TGCTAATTTT

ATTCGTTTAG CAAAATATGA TGGTGAAACA GGTTTTTATG AATTTTTCGA CAAAGAAACA

GGTGAAACCC GTGGCGATGA AGGCACATTC TTTGTGACAG ACGATGGCGA AAAGCGTATC

TTAATTTCGC ATACACAAAA CTATCAAGCG GTGGTCGATT TAACGGAAGT GACGAAAGAT

AAATTTACCT ATAAGCGAAT GGGTAAAGAT AAACACGGGA AAGATGTAGA AGTCTTTGTA

GAACATATCC CTTATTCTGA CGAGAAATTA ACCTTTACGA ACGGCCGTAA AGATTTAGAA

ACAGAAACTG GCAAGATTGT TACCAATGAA CCTGGGGATG ACATTTTAGG GGCCACATTA

TGGAATGGCA CGAAAGTTTT AGATGAAGAC GGTAACGATG TTACTGAAGC AAATAAAATG

TTTATTAGTT TAGCGAAATT TGATAATAAA ACAAGTAAAT ATGAATTCTT TGATTTAGAA

ACGGGTAAAA CACGTGGAGA TTTTGGTTAC TTCCAAGTAA TTGATAATAA CAAAATCCGT

GCTCACGTTT CAATTGGTGA CAATAAATAT GGAGCTGCAT TAGAATTAAC AGAATTAAAT

GATAAACGTT TTACGTATAC ACGAATGCGT AAAGACAACA ATGGCAAAGA AATTAAAGTC

TTTGTAGAAC ATGAACCATA TGAAGGAGAC TTTACGCCAG ACTTCACGTT CTAA

EF039-2 (SEQ ID NO:150)

MKKKKVFSA LTLLTFSTLL IAGCAGGANS ATDKSSAASS STAVSSSAEA

AKEQSKGQEL TEILSSTDWQ GTKVYDKNXN NLTAENANFI GLAKYDGETG FYEFFDKETG

ETRGDEGTFF VTDDGEKRIL ISDTQNYQAV VDLTEVTKDK FTYKRMGKDK DGKDVEVPVE

HIPYSDEKLT FTNGRKDLET ETGKIVTNEP GDDILGATLW NGTKVLDEDG NDVTEANKMF

ISLAKFDNKT SKYEFFDLET GKTRGDFGYF QVIDNNKIRA HVSIGDNKYG AALELTELND

KRFTYTRMGK DNNGKEIKVF VEHEPYEGDF TPDFTF

EF039-3 (SEQ ID NO:151)

TGCAACAG ATAAATCAAG TGCAGCTAGC TCAAGCACTG CAGTCTCTAG TTCAGCAGAA

GCAGCTAAAG AGCAATCAAA AGGACAAGAA TTAACAGAAA TTTTATCCAG TACTGATTGG

CAAGGCACAA AAGTTTACGA CAAAAATNAT AATAATTTAA CAGCAGAAAA TGCTAATTTT

ATTGGTTTAG CAAAATATGA TGGTGAAACA GGTTTTTATG AATTTTTCGA CAAAGAAACA

GCTGAAACCC GTGGCGATGA AGGCACATTC TTTGTGACAG ACGATGGCGA AAAGCGTATC

TTAATTTCGG ATACACAAAA CTATCAAGCG GTGGTCGATT TAACGGAAGT GACGAAAGAT

AAATTTACCT ATAAGCGAAT GGGTAAAGAT AAAGACGGGA AAGATGTAGA AGTCTTTGTA

GAACATATCC CTTATTCTGA CGAGAAATTA ACCTTTACGA ACGGCCGTAA AGATTTAGAA

ACAGAAACTG GCAAGATTGT TACCAATGAA CCTGGGGATG ACATTTTAGG GGCCACATTA

TGGAATGGCA CGAAAGTTTT AGATGAAGAC GGTAACGATG TTACTGAAGC AAATAAAATG

TTTATTAGTT TAGCGAAATT TGATAATAAA ACAAGTAAAT ATGAATTCTT TGATTTAGAA

ACGGGTAAAA CACGTGGAGA TTTTGGTTAC TTCCAAGTAA TTGATAATAA CAAAATCCGT

GCTCACGTTT CAATTGGTGA CAATAAATAT GGAGCTGCAT TAGAATTAAC AGAATTAAAT

GATAAACGTT TTACGTATAC ACGAATGGGT AAAGACAACA ATGGCAAAGA AATTAAAGTC

TTTGTACAAC ATGAACCATA TGAAGGAGAC TTTACGCCAG ACTTCACGTT CTAA

EF039-4 (SEQ ID NO:152)

ATDKSSAASS STAVSSSAEA

AKEQSKGQEL TEILSSTDWQ GTKVYDKNXN NLTAENANFI GLAKYDGETG FYEFFDKETG

ETRGDEGTFF VTDDGEKRIL ISDTQNYQAV VDLTEVTKDK FTYKRMGKDK DGKDVEVFVE

HIPYSDEKLT FTNGRKDLET ETGKIVTNEP GDDILGATLW NGTKVLDEDG NDVTEANKMF

ISLAKFDNKT SKYEFFDLET GKTRGDFGYF QVIDNNKIRA HVSIGDNKYG AALELTELND

KRFTYTRMGK DNNGKEIKVF VEHEPYEGDF TPDFTF

EF040-1 (SEQ ID NO:153)

TAGATTAGAA CCACTGGAGA AAAATCTCAT ATTTCTCTCG AGGAAAGGAA GTTGAGCACA

ATGAACAAAA AAATTTTAAT GGGGCTATTA AGTGTCGTGA CCATTCCATT ACTTGCTGCG

TGTCAAGGAG GAGAAACACC TTCCGCAGCG TCAAAAAATA GTCAAACGGT GACTACTCAA

AGTAGTGCAA AAACTGAAAG CACCAGTACA ACCCGTTCGG TAGCTCAAAC AACATCAAAA

GAGGAAGTGA AAGAACCGAT GAAGACCTAT GAAGTGGGTG CGCTTTTAGA AGCAGCCAAT

CAACGAGATA CGAAGAAGGT CAAGGAAATT TTACAAGATA CTACTTATCA AGTGGATGAA

GTCGACACAG AAGGCAACAC ACCGCTCAAT ATCGCTGTTC ACAATAATGA CATTGAGATT

GCAAAAGCGT TGATTGATCG GGGTGCCGAT ATTAATCTGC AAAACAGCAT TAGTGATAGT

CCCTATCTTT ATGCGGGAGC GCAAGGACGT ACGGAGATTT TAGCGTATAT GTTAAAACAT

GCGACCCCAG ATTTAAATAA CCATAACCGT TACGGTGGCA ATGCGTTAAT TCCGGCAGCT

GAAAAAGGAC ATATTGACAA TGTGAAGCTC TTGTTAGAAG ATGGACGAGA AGACATAGAT

TTCCAAAATG ACTTTGGCTA TACAGCATTG ATTGAGGCAG TGGGGTTACG TGAAGGGAAC

CAACTTTACC AAGATATTGT AAAATTGTTA ATGGAAAATG GTGCGGATCA ATCCATTAAA

GACAATTCTG GTCGAACAGC AATGGACTAT GCCAATCAAA AAGGTTATAC GGAAATTAGT

AAAATTTTAG CACAGTACAA CTAA

EF040-2 (SEQ ID NO:154)

M NKKILMGLLS VVTIPLLAAC QGGETPSAAS KNSQTVTTQS

SAKTESTSTT RSVAQTTSKE EVKEPMKTYE VGALLEAANQ RDTKKVKEIL QDTTYQVDEV

DTEGNTPLNI AVHNNDIEIA KALTDRGADI NLQNSISDSP YLYAGAQGRT EILAYMLKHA

TPDLNKHNRY GGNALIPAAE KGHIDNVKLL LEDGREDIDF QNDFGYTALI EAVGLREGNQ

LYQDIVKLLM ENGADQSIKD NSGRTAMDYA NQKGYTEISK ILAQYN

EF040-3 (SEQ ID NO:155)

AGCG TCAAAAAATA GTCAAACGGT GACTACTCAA

AGTAGTGCAA AAACTGAAAG CACCAGTACA ACCCGTTCGG TAGCTCAAAC AACATCAAAA

GAGGAAGTGA AAGAACCGAT GAAGACCTAT GAAGTGGGTG CGCTTTTAGA AGCAGCCAAT

CAACGAGATA CGAAGAAGGT CAAGGAAATT TTACAAGATA CTACTTATCA AGTGGATGAA

GTCGACACAG AAGGCAACAC ACCGCTCAAT ATCGCTGTTC ACAATAATGA CATTGAGATT

GCAAAAGCGT TGATTGATCG GGGTGCCGAT ATTAATCTGC AAAACAGCAT TAGTGATAGT

CCCTATCTTT ATGCGGGAGC GCAAGGACGT ACGGAGATTT TAGCGTATAT GTTAAAACAT

GCGACCCCAG ATTTAAATAA GCATAACCGT TACGGTGGCA ATGCGTTAAT TCCGGCAGCT

GAAAAAGGAC ATATTGACAA TGTGAAGCTC TTGTTAGAAG ATGGACGAGA AGACATAGAT

TTCCAAAATG ACTTTGGCTA TACAGCATTG ATTGAGGCAG TGGGGTTACG TGAAGGGAAC

CAACTTTACC AAGATATTGT AAAATTGTTA ATGGAAAATG GTGCGGATCA ATCCATTAAA

GACAATTCTG GTCGAACAGC AATGGACTAT GCCAATCAAA AAGGTTATAC GGAAATTAGT

AAAATTTTAG CACAGTACAA C

EF040-4 (SEQ ID NO:156)

AS KNSQTVTTQS

SAKTESTSTT RSVAQTTSKE EVKEPMKTYE VGALLEAANQ RDTKKVKEIL QDTTYQVDEV

DTEGNTPLNT AVHNIWIEIA KALTDRGADI NLQNSISDSP YLYAGAQGRT ETLAYMLKHA

TPDLNKHNRY GGNALIPAAE KGHIDNVKLL LEDGREDIDF QNDFGYTALI EAVGLREGNQ

LYQDIVKLLM ENGADQSIKD NSGRTAMDYA NQKGYTEISK ILAQYN

EF041-1 (SEQ ID NO:157)

TAATTATTAA NTTCTGATTT TTCAGAAAAT ACAGATTGCA TTATTTTAGG AGGCAACACT

ATGAAATTGA AAAAGTCATT AACATTCGGT GTGATTACAT TATTTAGCGT AACAACTTTA

GCCGCTTGTG GAGGCGGCGG AACGTCAGAT AGCTCAAGCG CGTCTGGTGG CGGTAAGGCA

AGTGGCGAAC AAGTTTTACG TGTCACAGAA CAACAAGAAA TGCCAACAGC TGATTTATCA

CTAGCAACAG NCAGAATTAG TTTTATTGCA TTAAATAATG TATATGAAGG AATTTATCGT

TTAGACAAAG ATAACAAAGT CCAACCTGCA GGTGCAGCGG AAAAAGCAGA AGTTTCTGAA

GATGGACTAA CATACAAAAT TAAATTAAAT AAAGATGCAA AATGGTCAGA CGGTAAACCA

GTGACTGCTA ATGACTATGT TTACGGATGG CAACGAACAG TTGATCCAGC GACAGCTTCT

GAATATGCTT ATCTGTATGC CTCTGTAAAA AATGGTGATG CCATTGCTAA AGGGGAAAAA

GATAAATCAG AATTAGGAAT TAAAGCAGTC AGTGATACAG AATTAGAAAT CACTTTAGAA

AAAGCAACAC CATACTTTGA TTACTTATTA GCTTTCCCAT CATTCTTCCC GCAACGTCAA

GACATTGTGG AAAAATATGG TAAAAATTAT GCATCAAACA GCGAAAGTGC TGTCTACAAT

GGTCCATTCG TCTTAGACGG CTTTGATGGT CCTGGTACAG ATACAAAATG GTCATTCAAG

AAAAACGATC AATATTGGGA TAAAGATACT GTGAAACTGG ACTCAGTAGA TGTGAATGTC

GTGAAAGAAT CACCAACCGC GTTGAACTTG TTCCAAGATG GACAAACAGA CGATGTCGTT

CTTTCTGGTG AATTAGCCCA ACAAATGGCC AATGACCCAG CTTTTGTTAG TCAAAAAGAA

GCATCAACAC AATATATGGA ACTAAATCAA CGTGATGAAA AATCACCATT TAGAAATGCG

AACTTACGTA AAGCAATTTC TTACTCAATC GACCGTAAAG CGTTAGTTGA ATCAATCCTT

AGGCGATGG

EF041-2 (SEQ ID NO:158)

M KLKKSLTFGV ITLFSVTTLA ACGGGGTSDS SSASGGGKAS

GEQVLRVTEQ QEMPTADLSL ATXRISFIAL NNVYEGIYRL DKDNKVQPAG AAEKAEVSED

GLTYKIKLNK DAKWSDGKPV TANDYVYGWQ RTVDPATASE YAYLYASVKN GDAIAKGEKD

KSELGIKAVS DTELEITLEK ATPYFDYLLA FPSFFPQRQD IVEKYGKNYA ENSESAVYNG

PFVLDGFDGP GTDTKWSFKK NDQYWDKDTV KLDSVDVNVV KESPTALNLF QDGQTDDVVL

SGELAQQMAN DPAFVSQKEA STQYMELNQR DEKSPFRNAN LRKAISYSID RKALVESILR

GW

EF041-3 (SEQ ID NO:159)

TTGTG GAGGCGGCGG AACCTCAGAT AGCTCAAGCG CGTCTGGTGG CGGTAAGGCA

AGTGGCGAAC AAGTTTTACG TGTCACAGAA CAACAAGAAA TGCCAACAGC TGATTTATCA

CTAGCAACAG NCAGAATTAG TTTTATTGCA TTAAATAATG TATATGAAGG AATTTATCGT

TTAGACAAAG ATAACAAAGT CCAACCTGCA GGTGCAGCGG AAAAAGCAGA AGTTTCTGAA

GATGGACTAA CATACAAAAT TAAATTAAAT AAAGATGCAA AATGGTCAGA CGGTAAACCA

GTGACTGCTA ATGACTATGT TTACGGATGG CAACGAACAG TTGATCCAGC GACAGCTTCT

GAATATGCTT ATCTGTATGC CTCTGTAAAA AATGGTGATG CCATTGCTAA AGGGGAAAAA

GATAAATCAG AATTAGGAAT TAAAGCAGTC AGTCATACAG AATTAGAAAT CACTTTAGAA

AAAGCAACAC CATACTTTGA TTACTTATTA GCTTTCCCAT CATTCTTCCC GCAACGTCAA

GACATTGTGG AAAAATATGG TAAAAATTAT GCATCAAACA GCGAAAGTGC TGTCTACAAT

GGTCCATTCG TCTTAGACGG CTTTGATGGT CCTGGTACAG ATACAAAATG GTCATTCAAG

AAAAACCATC AATATTGGGA TAAAGATACT GTGAAACTGG ACTCAGTAGA TGTGAATGTC

GTGAAAGAAT CACCAACCGC GTTGAACTTG TTCCAAGATG GACAAACAGA CGATGTCGTT

CTTTCTGGTG AATTAGCCCA ACAAATGGCC AATGACCCAG CTTTTGTTAG TCAAAAAGAA

GCATCAACAC AATATATGGA ACTAAATCAA CGTGATGAAA AATCACCATT TAGAAATGCG

AACTTACGTA AAGCAATTTC TTACTCAATC GACCGTAAAG CGTTAGTTGA ATCAATCCTT

AGGGGATGG

EF041-4 (SEQ ID NO:160)

CGCGGTSDS SSASGGGKAS

GEQVLRVTEQ QEMPTADLSL ATXRISFIAL NNVYEGIYRL DKDNKVQPAG AAEKAEVSED

GLTYKTKLNK DAKWSDGKPV TANDYVYGWQ RTVDPATASE YAYLYASVKN GDAIAKGEKD

KSELGIKAVS DTELEITLEK ATPYFDYLLA FPSFFPQRQD IVEKYGKNYA SNSESAVYNG

PFVLDGFDGP GTDTKWSFKK NDQYWDKDTV KLDSVDVNVV KESPTALNLF QDGQTDDVVL

SGELAQQMAN DPAFVSQKEA STQYMELNQR DEKSPFRNAN LRKAISYSTD RKALVESILR

OW

EF044-1 (SEQ ID NO:161)

TAAGATAAAA TTAGTTATAG CGTCTATAGG AGGAATAGTA TGAAAAAATT AGTTTGTGTT

ATTTTAGTTA TTTTTTTAAC AGGTTGTAGT TCTCAAAAAG CGAATGAACC TAAAAAACAA

GAAAATTCTA CCAATCATAC AACATCAATA AAAAGCAGTA CTAATCATTA CAGTTCTAGC

ATAGAAACAA GCTCTAATAA TAAACTAAAA GAAACTTCAG AAAGTGCCAG CACCACTCAA

ACTTCGTCAA AGTCGAAAAA TGAAGTATCT ACAAATGTCG AAGAAGCAAA TTCTTTAGAA

GCAACACCTT ATGCTGTCGA TCTTAGTAGC TTAAACAATC CACTCGTATT TAATTTTAAA

GGAATGAATG TGCCAACTTC AATTACGTTA GAGAACTTAA ATTCAACACC AACTGCTACC

TTCCGAACTA AATTGTTTGG GGCTGAAAAT GGTCAAGTGA AAGAAGCCAT TAATAAATAT

GAGCTATCTA TAAATACAAT TCCTACAAAA GAGATTAGAA TATTTTCAGC GGCCGATAAC

AGTATTCGCA CCGTTAAAGT AAATACAGAA TTAATTTTAG GAACTAATAT TTCTTCAAAC

GATGAACAAA ATAGATCGGG CACTTTATAC TTATTCAACA ATAAAAATGG TTCGATATCT

TTAATCACTC CTAACTACGC TGGCAATGTT ACGGATGATC AAAAAGACGT TATGCTAGAA

GTAATTCAAT AA

EF044-2 (SEQ ID NO:162)

MKKLVCVI LVIFLTGCSS QKANEPKKQE NSTNHTTSIK SSTNHYSSSI

ETSSNNKLKE TSESASTTQT SSKSKNEVST NVEEANSLEA TPYAVDLSSL NNPLVFNFKG

MNVPTSITLE NLNSTPTATF RTKLFGAENG QVKEAINKYE LSTNTIPTKE IRIFSAADNS

IRTVKVNTEL ILGTNTSSND EQNRSGTLYL FNNKNGSISL ITPNYAGNVT DDQKDVMLEV

IQ

EF044-3 (SEQ ID NO:163)

TTGTAGT TCTCAAAAAC CGAATGAACC TAAAAAACAA

GAAAATTCTA CCAATCATAC AACATCAATA AAAAGCAGTA CTAATCATTA CAGTTCTAGC

ATAGAAACAA GCTCTAATAA TAAACTAAAA GAAACTTCAG AAAGTGCCAG CACCACTCAA

ACTTCGTCAA AGTCGAAAAA TGAAGTATCT ACAAATGTCG AAGAAGCAAA TTCTTTAGAA

GCAACACCTT ATGCTGTCGA TCTTAGTAGC TTAAACAATC CACTCGTATT TAATTTTAAA

GGAATGAATG TGCCAACTTC AATTACGTTA GAGAACTTAA ATTCAACACC AACTGCTACC

TTCCGAACTA AATTGTTTGG GGCTGAAAAT GGTCAAGTGA AAGAAGCCAT TAATAAATAT

GAGCTATCTA TAAATACAAT TCCTACAAAA GAGATTAGAA TATTTTCAGC GGCCGATAAC

AGTATTCGCA CCGTTAAAGT AAATACAGAA TTAATTTTAG GAACTAATAT TTCTTCAAAC

GATGAACAAA ATAGATCGGG CACTTTATAC TTATTCAACA ATAAAAATGG TTCGATATCT

TTAATCACTC CTAACTACGC TGGCAATGTT ACGGATGATC AAAAAGACGT TATGCTAGAA

GTAATTCAA

EF044-4 (SEQ ID NO:164)

CSS QKANEPKKQE NSTNHTTSIK SSTNHYSSSI

ETSSNNKLKE TSESASTTQT SSKSKNEVST NVEEANSLEA TPYAVDLSSL NNPLVFNFKG

MNVPTSITLE NLNSTPTATF RTKLFGAENG QVKEAINKYE LSINTIPTKE IRIFSAADNS

TRTVKVNTEL ILGTNISSND EQNRSGTLYL FNNKNGSISL ITPNYAGNVT DDQKDVMLEV

IQ

EF045-1 (SEQ ID NO:165)

TAGCCAAAAA ATGAGGCAGG AAAAGAGATG AACAAGAAAC GGATTTTAGG TGCAATCACG

TTAGCTTCTG TGTTAGTATT CGGGTTAGCT GCATGTGGTG GCGGCAATAA AGGCGGGGGC

AATAAAGCAA CGGAAACAGA AGACATTTCA AAAATGCCAA TCGCTGTTAA AAATGATAAA

AAAGCAATTG ATGGCGGTAC ATTAGATGTC GCTGTAGTTA TGGATACACA ATTCCAAGGA

CTTTTCCAGC AACAATTTTA TCAAGACAAC TATGATGCAC AATACATGCT TCCAACGGTA

CAGCCATTAT TTAACAATGA TGCAGACTTT AAGATTGTCG ATGGGGGTCC TGCGGATCTG

AAATTAGATG AAGATCCCAA TACAGCAACC ATTAAATTAC GTGACAATTT GAAATGGTCT

GACGGTAAAG ATGTGACAGC CGATGACCTG ATTTTCTCTT ATGAAGTCAT TGGTCATAAA

GACTATACAG GGATTCGTTA TGATGATAAC TTTACGAATA TTGTTGGCAT GGAAGACTAC

CATGATGGTA AATCGCCAAC CATTTCTGGC ATAGAAAAAG TCAATGATAA AGAAGTTAAA

ATCACTTATA AAGAAGTTCA CCCAGGAATG CAACAATTAG GTGGCGGTGT TTGGGGCTCA

GTTTTACCAA AACATGCCTT TCAAGGAATT GCTGTTAAAG ACATGGAATC AAGCGATGCA

GTTCGTAAAA ACCCTGTGAC TATTGGACCA TACTACATGA GTAATATTGT GACAGGTGAA

TCTGTTGAAT ACCTACCAAA TGAGCATTAC TACGGTGGTA AACCTAAATT AGATAAATTA

GTGTTCAAAT CTGTTCCTTC TGCGAGCATT GTAGAAGCGA TGAAACCGAA ACAATACGAT

ATTGCATTAT CAATGCCAAC AGATACGTAT CCAACATACA AAGATACTGA AGGGTATCAA

ATCTTAGGAC GTCCCGAACA AGCCTACACG TATATTGGCT TTAAAATGGG TACGTTTGAC

AAAGAAACAA ATACAGTGAA ATACAATCCA AAAGCTAAAA TGGCAGATAA AAGCTTACGT

CAAGCCATGG GCTATGCAAT TGACAATGAT GCAGTCGGCC AAAAATTCTA CAACGGCTTA

CGAACAGGGG CAACAACGTT AATCCCACCA GTCTTCAAGA GCTTGCATGA TAGCGAAGCG

AAAGGCTATA CGCTTGATTT AGACAAAGCG AAAAAATTAT TAGACCATOC TGGTTATAAA

GACGTAGACG GCGATGGCAT TCGCGAAGAC AAAGAAGGCA AACCACTACA AATCAAGTTT

CCTTCAATGT CAGGCGCCGA AACTGCACAA CCACTTGCTC ATTACTATGT CCAACAATGG

AAAGAAATTG GCTTAAACCT AACGTATACA ACAGGACGCT TAATTGATTT CCAAGCATTC

TATGATAAAT TCAAAAATGA TGACCCAGAA GTACATATCT ATCAAGGCGC CTGGGGCACA

GGTTCAGATC CTTCACCAAC CGGCTTATAT GGTCCAAACT CACCCTTTAA CTATACACGT

TTTGACTCAG AAGAAAATAC TAAATTACTT GATGCGATTG ATTCAAAAGC ATCATTTGAT

GAACAAAAAC GTAAAAAAGC CTTCTACGAT TGGCAAGAGT ATGCCATTGA TGAAGCGTTT

GTAATCCCAA CGCTTTACAG AAATGAAGTC TTGCCTGTCA ACGACCGTGT AGTTGACTTT

ACTTGGCCAG TTGATACGAA AGATAATCCA TCCGCAACGG TGCGTGTCAC AGCAGACTCA

CGGAAATAA

EF045-2 (SEQ ID NO:166)

MN KKRILCAITL ASVLVFGLAA CGGGNKGGGN KATETEDISK MPIAVKNDKK

ATDGGTLDVA VVMDTQFQGL FQQEFYQDNY DAQYNLPTVQ PLFNNDADFK IVDGGPADLK

LDEDANTATI KLRDNLKWSD GKDVTADDVI FSYEVIGHKD YTGIRYDDNF TNIVGMEDYH

DGKSPTTSGI EKVNDKEVKI TYKEVHPGMQ QLGGGVWGSV LPKHAFEGIA VKDMESSDAV

RKNPVTIGPY YMSNTVTGES VEYLPNEHYY GGKPKLDKLV FKSVPSASIV EAMKAKQYDI

ALSMPTDTYP TYKDTEGYQT LGRPEQAYTY IGFKNGTFDK ETNTVKYNPK AKMADKSLRQ

AMGYAIDNDA VCQKFYNGLR TGATTLIPPV FKSLHDSEAK GYTLDLDKAK KLLDDAGYKD

VDGDGIREDK EGKPLEIKFA SMSGGETAQP LADYYVQQWK EIGLNVTYTT GRLIDFQAFY

DKLKNDDPEV DIYQCAWGTG SDPSPTGLYC PNSAFNYTRF ESEENTKLLD ATDSKASFDE

EKRKKAFYDW QEYAIDEAFV IPTLYRNEVL PVNDRVVDFT WAVDTKDNPW ATVGVTADSR

K

EF045-3 (SEQ ID NO:167)

ATGTGGTG CCGCCAATAA AGGCGGCCGC

AATAAAGCAA CGGAAACAGA AGACATTTCA AAAATGCCAA TCGCTGTTAA AAATGATAAA

AAAGCAATTG ATGGCCGTAC ATTAGATGTC GCTGTAGTTA TGGATACACA ATTCCAAGGA

CTTTTCCAGC AAGAATTTTA TCAACACAAC TATGATCCAC AATACATGCT TCCAACGGTA

CAGCCATTAT TTAACAATGA TGCAGACTTT AAGATTGTCG ATGGGGGTCC TGCGGATCTG

AAATTACATC AAGATCCCAA TACAGCAACC ATTAAATTAC CTGACAATTT GAAATGGTCT

GACCGTAAAG ATGTGACAGC CGATGACGTG ATTTTCTCTT ATGAAGTCAT TGCTCATAAA

GACTATACAG GGATTCGTTA TGATGATAAC TTTACGAATA TTGTTGGCAT GGAAGACTAC

CATGATGGTA AATCGCCAAC CATTTCTGGC ATAGAAAAAG TCAATGATAA AGAAGTTAAA

ATCACTTATA AAGAAGTTCA CCCAGGAATC CAACAATTAG GTGGCGGTGT TTGGGGCTCA

GTTTTACCAA AACATGCCTT TGAAGGAATT GCTGTTAAAG ACATGCAATC AAGCGATGCA

GTTCGTAAAA ACCCTGTGAC TATTGGACCA TACTACATGA CTAATATTGT GACAGGTGAA

TCTGTTGAAT ACCTACCAAA TGAGCATTAC TACGGTGGTA AACCTAAATT AGATAAATTA

GTGTTCAAAT CTGTTCCTTC TGCGACCATT GTAGAAGCGA TGAAAGCGAA ACAATACGAT

ATTGCATTAT CAATGCCAAC AGATACGTAT CCAACATACA AAGATACTGA AGGGTATCAA

ATCTTAGGAC GTCCCGAACA AGCCTACACG TATATTGGCT TTAAAATGGG TACGTTTCAC

AAAGAAACAA ATACAGTGAA ATACAATCCA AAACCTAAAA TGGCAGATAA AAGCTTACGT

CAAGCCATGG GCTATGCAAT TGACAATGAT GCAGTCGGCC AAAAATTCTA CAACGGCTTA

CGAACAGGGG CAACAACGTT AATCCCACCA GTCTTCAAGA GCTTGCATGA TAGCGAAGCG

AAAGGCTATA CGCTTGATTT AGACAAAGCG AAAAAATTAT TAGACGATGC TGGTTATAAA

GACGTAGACG GCGATGGCAT TCGCGAAGAC AAAGAAGGCA AACCACTAGA AATCAAGTTT

GCTTCAATGT CACGCGGCGA AACTGCACAA CCACTTGCTG ATTACTATGT CCAACAATGG

AAAGAAATTG GCTTAAACGT AACGTATACA ACAGGACGCT TAATTGATTT CCAAGCATTC

TATGATAAAT TGAAAAATGA TGACCCAGAA GTAGATATCT ATCAAGGCGC GTGOCGCACA

GGTTCAGATC CTTCACCAAC CGGCTTATAT GGTCCAAACT CAGCCTTTAA CTATACACGT

TTTGAGTCAC AAGAAAATAC TAAATTACTT GATGCGATTG ATTCAAAAGC ATCATTTGAT

GAAGAAAAAC GTAAAAAAGC CTTCTACGAT TGGCAAGAGT ATGCCATTGA TGAAGCGTTT

GTAATCCCAA CGCTTTACAG AAATGAAGTC TTGCCTGTCA ACGACCGTGT AGTTGACTTT

ACTTGGGCAG TTGATACGAA AGATAATCCA TGGGCAACGG TGGGTGTCAC AGCAGACTCA

CGGAAA

EF045-4 (SEQ ID NO:168)

CGGGNKCGGN KATETEDISK MPTAVKNDKK

AIDGGTLDVA VVMDTQFQGL FQQEFYQDNY DAQYMLPTVQ PLFNNDADFK IVDGGPADLK

LDEDANTATT KLRDNLKWSD GKDVTADDVT FSYEVIGHKD YTGIRYDDNF TNIVGMEDYH

DGKSPTISGI EKVNDKEVKI TYKEVHPGMQ QLGGGVWGSV LPKHAFEGIA VKDMESSDAV

RKNPVTIGPY YMSNIVTGES VEYLPNEHYY GGKPKLDKLV FKSVPSASIV EANKAKQYDI

ALSMPTDTYP TYKDTEGYQI LGRPEQAYTY IGFKMGTFDK ETNTVKYNPK AKMADKSLRQ

AMGYAIDNDA VGQKFYNGLR TGATTLTPPV FKSLHDSEAK GYTLDLDKAK KLLDDAGYKD

VDGDGIREDK EGKPLEIKFA SMSGGETAQP LADYYVQQWK EIGLNVTYTT GRLIDFQAFY

DKLKNDDPEV DIYQGAWGTG SDPSPTGLYG PNSAFNYTRF ESEENTKLLD AIDSKASFDE

EKRKKAFYDW QEYAIDEAFV IPTLYRNEVL PVNDRVVDFT WAVDTKDNPW ATVGVTADSR

K

EF046-1 (SEQ ID NO:169)

TAGGAGGATA TAATGAAAAA AAAACTTATT GTACTATTGT TAGCCTTATT TTTAACGGCA

TGTAGTAATA ATACTGGGGG AAAAAATAGC GACGCTTCAT CTACTGAAGT ATCAACTAAG

CAGCAAACTA CCCAGTCTTC TAAAAAAGAT AGTAGTAATC CGGACACAAC ACCAACTTCT

ACATCATCTA TAACAATTGA AACAACCGAG AATTTAAAGA ATAGAGAATT GAATCCAACA

GATGATGTTT CAAAAACTAG ACGACAATTG TATGAACAAG GAATTAACAG TTCAACAATT

ACGGATAAAG AACTAAAGGA ATATATATCA GAGGCTAAAG AACAAAAGAA AGATGTCATT

AATTATATTA AGCAAAAA

EF046-2 (SEQ ID NO:170)

MKKKLTV LLLALFLTAC SNNTGGKNSD ASSTEVSTKQ QTTQSSKKDS SNPDTTPTST

SSITIETTEN LKNRELNPTD DVSKTRRQLY EQGINSSTIT DKELKEYISE AKEQKKDVIN

YIKQK

EF046-3 (SEQ ID NO:171)

A

TGTAGTAATA ATACTGGGGG AAAAAATAGC GACGCTTCAT CTACTGAAGT ATCAACTAAG

CAGCAAACTA CCCAGTCTTC TAAAAAAGAT AGTAGTAATC CGGACACAAC ACCAACTTCT

ACATCATCTA TAACAATTGA AACAACCGAG AATTTAAAGA ATAGAGAATT GAATCCAACA

GATGATGTTT CAAAAACTAG ACGACAATTG TATGAACAAG GAATTAACAG TTCAACAATT

ACGGATAAAG AACTAAAGGA ATATATATCA GAGGCTAAAG AACAAAAGAA AGATGTCATT

AATTATATTA AGCAAAAA

EF046-4 (SEQ ID NO:172)

C SNNTGGKNSD ASSTEVSTKQ QTTQSSKKDS SNPDTTPTST

SSITIETTEN LKNRELNPTD DVSKTRRQLY EQGINSSTIT DKELKEYISE AKEQKKDVIN

YIKQK

EF047-1 (SEQ ID NO:173)

TAGGGAAAAC AAGGAGGAAT TCTTATGAAA AAGATAGGGC TTATTTCTAG TGCTTTTCTT

TTAACCCTTG CTTTAGCAGC ATGCGGCGGC GGAAAAAGTA CAGAAAATAC GGATAGTCGT

TCCAGTGCTG CGGAAAGTAC CACAGTCGAG AGTACAAAAG CATCTGCTAC AAAAGAATCA

AGTAGCAAAG CAACAACAAA ATCTAGTGAT GCGAAACCGT CAGGAACAAC AACAGCTGAT

TCGAAAGCAA CAGCTTCTTC TACGAAGGAA GCGGCAAATA ATGGCTCAGC AGAGAAGCAA

TCACCAGCGA AAAATGCGAA TCCAGATGAC CAAGCCAACC AAGTGCTTAA CCAGCTAGCA

AACATGTTTC CTGGTCAAGG CTTACCGCAG GCAATTTTAA CGAGTCAAAC GAATAACTTT

TTAACTGCAG CGACAACTTC ACAAGCGGAT CAAAACAATT TCCGTGTTTT ATATTATGCA

GAAAAAGAAG CGATTCCACT GAATGATGCA CGTGTCAATC AGTTAACGCC AATTAGTTCT

TTTGAGAAAA AAACATATGG CTCTGATGCC GAACCAAAAA ATGCAGTGAA CCAAATCATT

GACAATGGCG GTCAACCAGT AGATTTAGGT TACAATATTA CTGGGTATAA ACAAGGGGCG

GCAGGTTCTA GTTACTTATC TTGGCAAGAA GGCAATTGGA GTTTAGTCGT ACGGGCCTCA

AATATCAATG GTGAATCGCC TGATGATTTA GCGAAAAATG TTGTCAACAT TTTGGAACAA

CAAACATTAC CAGCACCGAA TACCGTTGGT CAAATCACAC TGAACGTGGC AGGAACCACT

GACTATAATC GAAACTCAGT AGTTTGGCAA GCCGGTACAG TCGTTTACTC TGTCCATCAT

TTTGACCCAA TTCAAGCAGT GAAGATGGCA ACATCAATGT AA

EF047-2 (SEQ ID NO:174)

MKK IGLISSAFLL TLALAACGGG KSTENTDSRS SAAESTTVES TKASATKESS

SKATTKSSDA KPSGTTTADS KATASSTKEA ANNGSAEKQS PAKNANPDDQ ANQVLNQLAN

MFPGQGLPQA ILTSQTNNFL TAATTSQADQ NNFRVLYYAE KEAIPVNDAR VNQLTPISSF

EKKTYGSDAE AKNAVNQIID NGGQPVDLGY NITGYKQGAA GSSYLSWQEG NWSLVVRASN

INGESPDDLA KNVVNILEQE TLPAPNTVGQ ITLNVAGTTD YNRNSVVWQA GTVVYSVHHF

DPIQAVKMAT SM

EF047-3 (SEQ ID NO:175)

ATGCGGCGGC GGAAAAAGTA CACAAAATAC GGATAGTCGT

TCCAGTGCTG CGGAAAGTAC CACAGTCGAG AGTACAAAAG CATCTGCTAC AAAAGAATCA

AGTAGCAAAG CAACAACAAA ATCTACTGAT GCGAAACCGT CAGGAACAAC AACAGCTGAT

TCGAAAGCAA CAGCTTCTTC TACGAAGGAA GCGGCAAATA ATGGCTCAGC AGAGAAGCAA

TCACCAGCGA AAAATGCGAA TCCAGATGAC CAAGCCAACC AAGTGCTTAA CCAGCTAGCA

AACATGTTTC CTGGTCAAGG CTTACCGCAG GCAATTTTAA CGAGTCAAAC GAATAACTTT

TTAACTGCAG CGACAACTTC ACAAGCGGAT CAAAACAATT TCCGTGTTTT ATATTATGCA

GAAAAAGAAG CGATTCCAGT GAATGATGCA CGTGTCAATC AGTTAACGCC AATTAGTTCT

TTTGAGAAAA AAACATATGG CTCTGATGCC GAAGCAAAAA ATGCAGTGAA CCAAATCATT

GACAATGGCG GTCAACCAGT AGATTTAGGT TACAATATTA CTGGGTATAA ACAAGGGGCG

GCAGGTTCTA GTTACTTATC TTGGCAAGAA GGCAATTGGA GTTTAGTCGT ACGGGCCTCA

AATATCAATG GTGAATCGCC TGATGATTTA GCGAAAAATG TTGTCAACAT TTTGGAACAA

GAAACATTAC CAGCACCGAA TACCGTTGGT CAAATCACAC TGAACGTGGC AGGAACCACT

GACTATAATC GAAACTCAGT AGTTTGGCAA GCCGGTACAG TCGTTTACTC TGTCCATCAT

TTTGACCCAA TTCAACCAGT GAAGATGGCA ACATCAATGT AA

EF047-4 (SEQ ID NO:176)

CGGG KSTENTDSRS SAAESTTVES TKASATKESS

SKATTKSSDA KPSGTTTADS KATASSTKEA ANNGSAEKQS PAKNANPDDQ ANQVLNQLAN

MFPGQGLPQA ILTSQTNNFL TAATTSQADQ NNFRVLYYAE KEATPVNDAR VNQLTPTSSF

EKKTYGSDAE AKNAVNQIID NGGQPVDLCY NITGYKQGAA GSSYLSWQEG NWSLVVRASN

INGESPDDLA KNVVNILEQE TLPAPNTVGQ ITLNVAGTTD YNRNSVVWQA GTVVYSVHHF

DPIQAVKMAT SM

EF048-1 (SEQ ID NO:177)

TAAGGAGAAA AGTTCATGAA AAAAAGAAAG GTTTTATTTA CAGCAGTTAT GGTATTGGCA

GGATTACAGT TGCTAAGTGG TTGCGGCAAA ACAGAAGCTT CGGCAAATGA TACGGTAGTC

TTGCGCTATG CGTATGCTAG TAATAGCCAA CCAGTTATCG ATTCTATGAA GAAATTCGGT

GAATTAGTAG AGGAAAAAAC AGATGGTAAA GTTCAAATTG AATATTTTCC AGATGGTCAA

TTAGGAGGAC AAACAGAACT AATTGAATTA ACACAAACAG GTGCAATTCA TTTTGCAAAG

GTCAGTGGAT CAGCATTAGA AAGTTTTTCT AAAGATTATT CTGTATTTGC CATTCCGTAT

ATTTTTGATA ATGAAAAACA TTTTTTTAAA GTAATGCATA ATCAAGCGCT AATGCAACCA

GTGTATGATT CTACAAAAAA ATTAGGATTT GTTGCTTTAA CTTATTATGA CTCTGGTCAA

CGAAGTTTTT ATATGAGCAA AGGGCCTGTT ACATCTCCAG ATGATTTGAA AGGTAAAAAA

ATTCGGCTCA TGCAAACTGA AACCGCCATC AAAATGGTAG AACTTTTAGG GGCTTCGCCA

GTACCTATGG GTAGTTCGGA AGTATATACT TCTCTACAAT CTAATCTAAT CAACGGTGCA

GAGAATAATC AGTTCGTTTT ATATACACCT GGTCATGCTG GTGTGGCTAA GTATTATTCT

TATGATCAGC ATACTCGAGT GCCAGATATT GTGATTATGA ACGAGGGAAC AAAAGAACGT

TTGACAGCGA AACAAGAACA ACCGATTGAA GAAGCAGCAA AACAATCGAC CGCTTTTGAA

AAAACGGTCT TTAAAGAAGC GGTTGAAGAA GAAAAGAAAA AAGCACAAGC AGAATATGGC

GTTGTGTTCA ATCAAGTAGA CAGTGAACCA TTCCAAAAAC TTGTTCAACC CTTGCATCAA

TCATTCAAAA ATAGCTCAGA ACATGGCGAA CTGTATCAGG CTATTCGCCA GTTGGCGGAC

TAA

EF048-2 (SEQ ID NO:178)

MKKRKV LFTAVMVLAG LQLLSGCGKT EASANDTVVL RYAYASNSQP VIDSMKKFGE

LVEEKTDGKV QIEYFPDGQL GOETELTELT QTGATDFAKV SGSALESFSK DYSVFAIPYI

FDNEKHFFKV MDNQALMQPV YDSTKKLGEV GLTYYDSGQR SFYMSKGPVT SPDDLKGKKI

RVMQSETAIK MVELLGGSPV PMGSSEVYTS LQSNLINGAE NNEFVLYTAG HGGVAKYYSY

DEHTRVPDIV IMNEGTKERL TAKQEQATEE AAKESTAFEK TVFKEAVEEE KKKAQAEYGV

VFNQVDSEPF QKLVQPLHES FKNSSEHGEL YQAIRQLAD

EF04S-3 (SEQ ID NO:179)

TTGCGGCAAA ACAGAAGCTT CGGCAAATGA TACGGTAGTC

TTGCGCTATG CGTATGCTAG TAATAGCCAA CCAGTTATCG ATTCTATGAA GAAATTCGGT

GAATTAGTAG AGGAAAAAAC AGATGGTAAA GTTCAAATTG AATATTTTCC AGATGGTCAA

TTAGGACGAC AAACAGAACT AATTGAATTA ACACAAACAG GTGCAATTGA TTTTGCAAAG

GTCAGTGGAT CACCATTAGA AAGTTTTTCT AAAGATTATT CTGTATTTGC CATTCCGTAT

ATTTTTCATA ATGAAAAACA TTTTTTTAAA GTAATGGATA ATCAAGCGCT AATGCAACCA

GTGTATGATT CTACAAAAAA ATTAGGATTT GTTGGTTTAA CTTATTATGA CTCTGGTCAA

CGAAGTTTTT ATATGAGCAA AGGGCCTGTT ACATCTCCAG ATGATTTGAA AGGTAAAAAA

ATTCGGGTCA TGCAAAGTGA AACCGCCATC AAAATGGTAG AACTTTTAGG GGGTTCGCCA

GTACCTATGG GTAGTTCCGA ACTATATACT TCTCTACAAT CTAATCTAAT CAACGGTGCA

GAGAATAATG AGTTCGTTTT ATATACAGCT GGTCATGGTG GTGTGGCTAA GTATTATTCT

TATGATGAGC ATACTCGAGT GCCAGATATT GTGATTATGA ACGAGGGAAC AAAAGAACGT

TTGACAGCGA AACAAGAACA AGCGATTGAA GAAGCAGCAA AAGAATCGAC CGCTTTTGAA

AAAACGGTCT TTAAAGAAGC GGTTGAAGAA GAAAAGAAAA AAGCACAAGC AGAATATGGC

GTTCTGTTCA ATCAAGTAGA CAGTOAACCA TTCCAAAAAC TTGTTCAACC GTTGCATGAA

TCATTCAAAA ATAGCTCAGA ACATGGCGAA CTGTATCAGG CTATTCGCCA GTTGGCGCAC

TAA

EF048-4 (SEQ ID NO:180)

CGKT EASANDTVVL RYAYASNSQP VIDSMKKFGE

LVEEKTDGKV QIEYFPDGQL OGETELIELT QTGAIDFAKV SCSALESFSK DYSVFAIPYI

FDNEKHFFKV MDNQALMQPV YDSTKKLGFV GLTYYDSGQR SFYMSKGPVT SPDDLKGKKI

RVMQSETAIK MVELLGGSPV PMGSSEVYTS LQSNLINGAE NNEFVLYTAG HCGVAKYYSY

DEHTRVPDIV IMNEGTKERL TAKQEQATEE AAKESTAFEK TVFKEAVEEE KKKAQAEYGV

VFNQVDSEPF QKLVQPLHES FKNSSEHGEL YQAIRQLAD

FF049-1 (SEQ ID NO:181)

TGAGACTCTT TCTTTTTCAA AATGAGGTAT GGTATAGTTA TAACAGANAT AAAACTANAA

AAAACAGGAG TGCATAAGAG AATGAAGAAA AAACTAATCT TAGCTGCAGC GGGCGCAATG

GCCGTTTTTA GTTTAGCACC GTGTTCAAGC GCTTCAAAAC ATATCCCAAC AATGAAAGGT

TCAACAATTA CTGTTGATGA TTTTTATAAC CAAATTAAAG AACAAAGCAC TAGCCAACAA

GCGTTTAGCC AAATGGTTAT TTATAAAGTC TTTGAAGAAA AATATGGCGA CAAAGTAACT

GACAAAGANA TTCAAAAAAA CTTTGACGAA GCCAAAGAAC AAGTAGAAGC ACAAGGCGGA

AAGTTCTCTG ATGCATTAAA ACAAGCTCGT TTAACTGAAA AAACATTCAA GAAACAGTTA

AAACAAAGAG CAGCCTATGA TGCAGGTCTA AAAGCCCACT TAAAAATTAC AGATGAAGAC

TTAAAAACAG CTTGGGCAAG TTTCCATCCA CAAGTAGAAG CACAAATTAT CCAAGTTGCT

TCAGAAGATG ATGCCAAAGC TGTCAAGAAA GAAATCACTG ACGGCGGCGA TTTCACAAAA

ATTCCTAAAG AAAAATCAAC AGATACTGCT ACGAAAAAAG ATGGCGGTAA AATTAAATTT

GATTCACAAG CAACAACTGT TCCTCCCGAA GTTAAAGAAG CTGCCTTCAA ATTAAAAGAT

GGCGAAGTGT CAGAACCAAT TGCTGCAACA AATATGCAAA CCTACCAAAC AACCTACTAT

GTAGTCAAAA TGACGAAAAA CAAAGCAAAA GGCAATCACA TGAAACCTTA TGAAAAAGAC

ATCAAGAAAA TTGCTGAAGA AACAAAATTA GCCGATCAAA CATTTGTTTC GAAAGTCATT

AGTGACGAAT TAAAAGCGGC CAATGTGAAA ATTAAAGATG ATGCCTTCAA GAACGCTTTA

GCAGGCTACA TGCAAACTGA ATCTTCAAGC GCTTCTTCAG AGAAAAAAGA ATCAAAATCA

AGTGATTCTA AAACAAGCGA TACCAAAACA AGCGACTCTG AAAAAGCAAC AGATTCTTCA

AGCAAAACAA CAGAATCTTC TTCTAAATAA

EF049-2 (SEQ ID NO:182)

MKKK LILAAAGAIMA VFSLAACSSG SKDIATMKGS

TITVDDFYNQ IKEQSTSQQA FSQMVIYKVF EEKYGDKVTD KXTQKNFDEA KEQVEAQGGK

FSDALKQAGL TEKTFKKQLK QEAAYDAGLK AHLKITDEDL KTAWASFHPE VEAQIIQVAS

EDDAKAVKKE ITDGGDFTKI AKEKSTDTAT KKDGGKIKFD SQATTVPAEV KEAAFKLKDG

EVSEPTAATN MQTYQTTYYV VKNTKNKAKG NDMKPYEKEI KKTAEETKLA DQTFVSKVTS

DELKAANVKI KDDAFKNALA GYMQTESSSA SSEKKESKSS DSKTSDTKTS DSEKATDSSS

KTTES SSK

EF049-3 (SEQ ID NO:183)

GTGTTCAAGC GGTTCAAAAG ATATCGCAAC AATGAAAGGT

TCAACAATTA CTGTTGATGA TTTTTATAAC CAAATTAAAG AACAAAGCAC TAGCCAACAA

GCGTTTAGCC AAATGGTTAT TTATAAAGTC TTTGAAGAAA AATATGGCGA CAAAGTAACT

GACAAAGANA TTCAAAAAAA CTTTGACGAA GCCAAAGAAC AAGTAGAAGC ACAAGGCGGA

AAGTTCTCTG ATGCATTAAA ACAAGCTGGT TTAACTGAAA AAACATTCAA GAAACACTTA

AAACAAAGAG CAGCCTATGA TGCAGGTCTA AAAGCCCACT TAAAAATTAC AGATGAAGAC

TTAAAAACAG CTTGGGCAAG TTTCCATCCA GAAGTAGAAG CACAAATTAT CCAAGTTGCT

TCAGAAGATG ATGCCAAAGC TGTCAAGAAA GAAATCACTG ACGGCGGCGA TTTCACAAAA

ATTGCTAAAG AAAAATCAAC AGATACTGCT ACGAAAAAAG ATGGCGGTAA AATTAAATTT

GATTCACAAG CAACAACTGT TCCTGCCGAA GTTAAAGAAG CTGCCTTCAA ATTAAAAGAT

GGCGAAGTGT CAGAACCAAT TGCTGCAACA AATATGCAAA CCTACCAAAC AACCTACTAT

GTAGTGAAAA TGACGAAAAA CAAAGCAAAA GGCAATGACA TGAAACCTTA TGAAAAAGAG

ATCAAGAAAA TTGCTGAAGA AACAAAATTA GCCGATCAAA CATTTGTTTC GAAAGTCATT

AGTGACGAAT TAAAAGCGGC CAATGTGAAA ATTAAAGATG ATGCCTTCAA GAACGCTTTA

GCAGGCTACA TGCAAACTGA ATCTTCAAGC GCTTCTTCAG AGAAAAAAGA ATCAAAATCA

AGTGATTCTA AAACAAGCGA TACCAAAACA AGCGACTCTG AAAAAGCAAC AGATTCTTCA

AGCAAAACAA CAGAATCTTC TTCTAAATAA

EF049-4 (SEQ lED NO:184)

CSSG SKDIATMKGS

TITVDDFYNQ IKEQSTSQQA FSQMVIYKVF EEKYGDKVTD KXIQKNFDEA KEQVEAQGGK

FSDALKQAGL TEKTFKKQLK QRAAYDAGLK AHLKITDEDL KTAWASFHPE VEAQIIQVAS

EDDAKAVKKE ITDGGDFTKI AKEKSTDTAT KKDGGKIKFD SQATTVPAEV KEAAFKLKDG

EVSEPIAATN MQTYQTTYYV VKNTKNKAKG NDMKPYEKEI KKIAEETKLA DQTFVSKVIS

DELKAANVKI KDDAFKNALA GYMQTESSSA SSEKKESKSS DSKTSDTKTS DSEKATDSSS

KTTESSSK

EF050-1 (SEQ ID NO:185)

TAGGGTCTGG AAAAGCAGTC AACTGACTTC TTTTCCAAGC CCTTTTTTAG TTCATCGCAG

AAAGGATGNA AAAAAATGAA CATGCCCAAA AATATCNGTT ATTTTTCTTT GCTAATGGGT

CTTGTTCTAT TATTAAGTGC TTGCCAAATT GGGGCAACTA CGAAGGATGA CAACCAAGCC

GCCACAAAAG AAGCAACTGT TGAGTTAAAC CGCACAACAA CACCAACGCT TTTTTTTCAT

GGTTACGCAG GAACTAAAAA TTCGTTTGGC TCCTTACTGC ATCGCTTGGA GAAACAAGGT

GCCACAACTC AAGAATTAGT GCTACTCGTT AAACCTGATG GGACCGTGGT TAAAGAGCGA

GGAGCTTTAA GTGGCAAAGC GACGAATCCC AGTGTTCAAG TTCTATTTGA AGATAATAAA

AACAATGAAT GGAATCAAAC AGAATGGATA AAAAACACAT TACTCTATTT ACAAAAAAAT

TATCAAGTGA ACAAAGCCAA TATTGTCGGG CACTCTATGG GTGGTGTTAG TGGTTTACGT

TATTTAGGAA CCTATGGGCA AGATACATCG TTACCTAAAA TTGAAAAATT CGTCAGCATT

GGAGCACCTT TCAATGATTT TATTGATACG AGTCAACAGC AAACCATCGA AACGGAACTA

GAAAACGGCC CCACAGAAAA AAGTAGCCGC TATTTGGATT ATCAAGAGAT GATTAATGTT

GTTCCAGAAA AACTGCCCAT TTTATTAATT GGTGGTCAAT TAAGTCCAAC AGATTTAAGT

GATGGAACGG TGCCGTTATC TAGTGCCTTA GCAGTCAACG CCTTGCTAAG ACAGCGAGGA

ACTCAAGTCA CTAGCCAGAT TATTAAAGGA GAAAATGCAC AACATAGTCA ATTACATGAA

AATCCTGAAG TAGATCAATT GCTAATCGAA TTTCTATGGC CGAGTAAAAA ATAG

EF050-2 (SEQ ID NO:186)

HNMPKN IXYFSLLMGL VLLLSACQIG ATTKDDNQAA

TKEATVELNR TTTPTLFFHG YAGTKNSFGS LLHRLEKQGA TTQELVLLVK PDGTVVKERG

ALSGKATNPS VQVLFEDNKN NEWNQTEWIK NTLLYLQKNY QVNKANIVGH SMGGVSGLRY

LGTYGQDTSL PKIEKFVSIG APFNDFIDTS QQQTIETELE NGPTEKSSRY LDYQEMINVV

PEKLPILLIG GQLSPTDLSD GTVPLSSALA VNALLRQRGT QVTSQIIKGE NAQHSQLHEN

PEVDQLLIEF LWPSKK

EF050-3 (SEQ ID NO:187)

TTGCCAAATT GGGGCAACTA CGAAGGATGA CAACCAAGCC

GCCACAAAAG AAGCAACTGT TCAGTTAAAC CGCACAACAA CACCAACGCT TTTTTTTCAT

GGTTACGCAG GAACTAAAAA TTCGTTTGGC TCGTTACTCC ATCGCTTGGA GAAACAAGGT

GCCACAACTC AAGAATTAGT GCTACTCGTT AAACCTGATG GGACCGTCGT TAAAGAGCGA

GGAGCTTTAA GTGGCAAAGC GACGAATCCC AGTGTTCAAG TTCTATTTGA AGATAATAAA

AACAATGAAT GGAATCAAAC AGAATGGATA AAAAACACAT TACTCTATTT ACAAAAAAAT

TATCAAGTGA ACAAAGCCAA TATTGTCGGG CACTCTATGG GTGGTGTTAG TCGTTTACGT

TATTTAGGAA CCTATGGGCA AGATACATCG TTACCTAAAA TTGAAAAATT CGTCAGCATT

GGAGCACCTT TCAATGATTT TATTGATACG AGTCAACAGC AAACCATCGA AACGGAACTA

GAAAACGGCC CCACAGAAAA AAGTAGCCGC TATTTGGATT ATCAAGAGAT GATTAATGTT

GTTCCAGAAA AACTGCCCAT TTTATTAATT GGTGGTCAAT TAAGTCCAAC AGATTTAAGT

GATGGAACGG TGCCGTTATC TAGTGCCTTA GCAGTCAACG CCTTGCTAAG ACAGCGAGGA

ACTCAAGTCA CTAGCCAGAT TATTAAAGGA GAAAATGCAC AACATAGTCA ATTACATGAA

AATCCTGAAG TAGATCAATT GCTAATCGAA TTTCTATGCC CGAGTAAAAA ATAG

EF050-4 (SEQ ID NO:188)

CQIG ATTKDDNQAA

TKEATVELNR TTTPTLFFHG YAGTKNSFGS LLHRLEKQGA TTQELVLLVK PDGTVVKERG

ALSGKATNPS VQVLFEDNKN NEWNQTEWIK NTLLYLQKNY QVNKANIVGH SMGGVSGLRY

LGTYGQDTSL PKIEKFVSIG APFNDFIDTS QQQTIETELE NGPTEKSSRY LDYQEMINVV

PEKLPILLIG GQLSPTDLSD GTVPLSSALA VNALLRQRGT QVTSQIIKGE NAQHSQLHEN

PEVDQLLIEF LWPSKK

EF051-1 (SEQ ID NO:189)

TAAAAGAAAA GAGGCGTTCA AATGTCTAAA CAAAAAAAGG CTGTGTTCCT GCTTAGTTTA

TTCAGTTTAG TTGCCCTAAT TGCTGCATGT ACAAATCAGC CGCAAAAAGA AACAGTTTCA

ACAAAAAAAG AAGAAATAAC CCTTGCGGCA GCAGCTAGCT TAGAATCAGT CATGGAGAAG

AAAATTATTC CAGCCTTTGA AAAAGAGCAT CCAGATATTC AGGTAACTGG AACCTATGAT

AGTTCTGGAA AATTACAGAT GCAAATTGAA AAAGGCCTAA AAGCCGATGT ATTTTTCTCA

GCTTCGACAA AACAAATGAA TGCATTGGTT GCAGAAAAAC TAATTAATAA AAAAAGTGTC

GTTCCTTTAT TGGAAAACCA GCTCGTTCTT ATTGTGCCTA ACCAAGATCA AGCAAAGTGG

CATGATTTTT CTGATTTAAA AAAAGCCCAA ATGATAGCAA TTGGTGATCC TGCAAGTGTT

CCAGCTGGTC AATATGCCGA AGAAGGCTTA AAAGCTTTAG GCGCTTGGTC TTATGTAGAA

AAACACGCAA GCTTTGGCAC GAATGTAACA GAAGTCCTTG AATGGGTAGC TAATGCAAGT

GCAGAAGCTG GCTTAGTTTA TGCGACAGAT GCAGCAACCA ATTCAAAAGT AGCGATTGTT

GCGGCCATGC CTGAAGCTGT TTTGAAAAAG CCAATTATCT ATCCAGTTGG TAAAGTTGCC

GCCTCTAAGA AACAAAAATC AGCAGATGCT TTTTTAAATT TTTTACAGAG TCAACAATGC

AGAAAATATT TTGANAATAT TGGCTTTAAG TTAACAAAGT AG

EF051-2 (SEQ ID NO:190)

MSKQ KKAVFLLSLF SLVALIAACT NQPQKETVST KKEEITLAAA ASLESVMEKK

IIPAFEKEHP DIQVTGTYDS SGKLQMQIEK GLKADVFFSA STKQMNALVA EKLINKKSVV

PLLENQLVLI VPNQDQAKWH DFSDLKKAQM IAIGDPASVP AGQYAEEGLK ALGAWSYVEK

HASFGTNVTE VLEWVANASA EAGLVYATDA ATNSKVAIVA AMPEAVLKKP IIYPVGKVAA

SKKQKSADAF LNFLQSQQCR KYFXNIGFKL TK

EF051-3 (SEQ ID NO:191)

ATGT ACAAATCAGC CGCAAAAAGA AACAGTTTCA

ACAAAAAAAG AAGAAATAAC CCTTGCGGCA GCAGCTAGCT TAGAATCAGT CATGGAGAAG

AAAATTATTC CAGCCTTTGA AAAAGAGCAT CCAGATATTC AGGTAACTGG AACCTATGAT

AGTTCTGGAA AATTACAGAT GCAAATTGAA AAAGGCCTAA AAGCCGATGT ATTTTTCTCA

GCTTCGACAA AACAAATGAA TGCATTGGTT GCAGAAAAAC TAATTAATAA AAAAAGTGTC

GTTCCTTTAT TGGAAAACCA GCTCGTTCTT ATTGTGCCTA ACCAAGATCA AGCAAAGTGG

CATGATTTTT CTGATTTAAA AAAAGCCCAA ATGATAGCAA TTGGTGATCC TGCAAGTGTT

CCAGCTGGTC AATATGCCGA AGAAGGCTTA AAAGCTTTAG GCGCTTGGTC TTATGTAGAA

AAACACGCAA GCTTTGGCAC GAATGTAACA GAAGTCCTTG AATGGGTAGC TAATGCAAGT

GCAGAAGCTG GCTTAGTTTA TGCGACAGAT GCAGCAACCA ATTCAAAAGT AGCGATTGTT

GCGGCCATGC CTGAAGCTGT TTTGAAAAAG CCAATTATCT ATCCAGTTGG TAAAGTTGCC

GCCTCTAAGA AACAAAAATC AGCAGATGCT TTTTTAAATT TTTTACAGAG TCAACAATGC

AGAAAATATT TTGANAATAT TGGCTTTAAG TTAACAAAGT AG

EF051-4 (SEQ ID NO:192)

CT NQPQKETVST KKEEITLAAA ASLESVMEKK

IIPAFEKEHP DIQVTGTYDS SGKLQMQIEK GLKADVFFSA STKQMNALVA EKLINKKSVV

PLLENQLVLI VPNQDQAKWH DFSDLKKAQM IAIGDPASVP AGQYAEEGLK ALGAWSYVEK

HASFGTNVTE VLEWVANASA EAGLVYATDA ATNSKVAIVA AMPEAVLKKP IIYPVGKVAA

SKKQKSADAF LNFLQSQQCR KYFXNIGFKL TK

EF052-1 (SEQ ID NO:193)

TAAAGTAGGA GAAGCGCAAG CGAAAAAAGT GAATCAATCG GCAGCGTATC AAGTAGTGAT

CCCACAATGG GTACCATGGG TAGCATTATC TTTGACAGTA GCACTTGCTG GATTGATTGC

TTACTTAGTT CGTCGTGGAG AGAAGTGGAA AAACGAAGGG GAAGTGACAT AATGAGANGA

NGAAATCTTC NGTTTTTATT ATTGTTGGTT CTATTAATTT ATATTCCTCA AACAACTTAT

GCAGAAAATA GGGAGACCAC AGAAGTCGGA ATCGGGTTTA CAAAAACTTC AGACATACCA

TCAAAAAAAA ATCCAGTTGT GAATGTATTG CCGCAAACAA CCATTCAATC GCTATCAATC

GTTCGTAGCA GAACGCAAAT AAAAAGATTA CCTAAAACTG GTGACAATCG AATAACTTGG

CTAAGCTGGT TTGGCATATT GTTTTTAATA AGTAGTTTTT GGCTGTTTCT ATTTAGACAA

TTATGTAGAA AAGGAGAATA A

EF052-2 (SEQ ID NO:194)

MRXX

NLXFLLLLVL LIYIPQTTYA ENRETTEVOT GFTKTSDIPS KKNPVVNVLP QTTIQSLSIV

RSRTQIKRLP KTGDNRITWL SWFGILFLIS SFWLFLFRQL CRKGE

EF052-3 (SEQ ID NO:195)

AGAAAATA GGGAGACCAC AGAAGTCGGA ATCGGGTTTA CAAAAACTTC AGACATACCA

TCAAAAAAAA ATCCAGTTGT GAATGTATTG CCGCAAACAA CCATTCAATC GCTATCAATC

GTTCGTAGCA GAACGCAAAT AAAAAGAT

EF052-4 (SEQ ID NO:196)

ENRETTEVGI GFTKTSDIPS KKNPVVNVLP QTTIQSLSIV

RSRTQIKR

EF053-1 (SEQ ID NO:197)

TAGTCATGGC ACCATAACAA GGAGGAGAGA AGTGAGATGA AAAAATACCT TTTGCTTAGT

TGTTTTTTAG GTCTTTTCAG CTTCTGTCAT TCACACACTG CGTTTGGAGA AGCAGCTTAT

GAAAATAGTG GTGTTGTCTC CTTTTATGGA ACGTATGAAT ATCCCACAGA AGAGTCGACA

ACAGCGACTA GTAATTCTTC CACAACGACC GAACCCACCA AGCCAGCTGA CCGAGGCGCT

TCATCCGTCC TTTCTTCTGG CGTATATGGA TCGCGACAAG GAAGATTACC AGCGACAGGT

ACCACCAATC AAGCACCATT TATTTATTTG GGAATCAGCC TTATCACTAT ACGCATATTA

TTTATTAAAA GGAGAAGAGA AGATGAAAAA AACAGTATTA GCAGTAGTAG GGATTGTAGG

ATTTAG

EF053-2 (SEQ ID NO:198)

MKKYLLLSC FLGLFSFCHS DTAFGEAAYE NSGVVSFYGT YEYPTEESTT

ATSNSSTTTE PTKPADGGAS SVLSSGVYGS RQGRLPATGT TNQAPFIYLG ISLITIGILF

IKRRREDEKN SISSSRDCRI

EF053-3 (SEQ lED NO:199)

TTTGGACA AGCAGCTTAT

GAAAATAGTG GTGTTGTCTC CTTTTATGGA ACGTATGAAT ATCCCACAGA AGAGTCGACA

ACAGCGACTA GTAATTCTTC CACAACGACC GAACCCACCA AGCCAGCTGA CGGAGGCGCT

TCATCCGTCC TTTCTTCTGG CGTATATCGA TCGCGACAAG GAAGA

EF053-4 (SEQ ID NO:200)

FGEAAYE NSGVVSFYGT YEYPTEESTT

ATSNSSTTTE PTKPADGGAS SVLSSGVYGS RQGR

EF054-1 (SEQ ID NO:201)

TAAATAAAAA ATTATTTGGA GGAAATTACA ATGAAAAAAA TTATTTTATC AAGCTTGTTT

AGTGCAGTAC TAGTATTCGG TGGCGGAAGT ATAACAGCAT TCGCTGACGA TTTAGGACCA

ACAGATCCAG CAACTCCACC AATTACCGAA CCAACTGATT CTAGTGAACC TACGAATCCT

ACTGACCCGG TGGATCCTGC AGAACCGCCA GTAATACCAA CTGATCCAAC AGAACCAAGC

AAGCCAACCG AGCCTACAAC ACCGAGTGAG CCAGAAAAGC CAACAGAACC AACAACGCCA

ATTGATCCTG GAACGCCGGT TGAACCGACT GAACCAAGCG AGCCAACAGA ACCTAGTCAA

CCAACCGAGC CTACAACACC AAGCGAACCA GAAAAACCTG TTACTCCAGA ACAACCGAAA

GAACCAACTC AACCAGTGAT TCCAGAAAAA CCAGCAGAAC CAGAAACACC AAAAACTCCT

GAACAGCCCA CTAAACCAAT AGACGTAGTC GTTACACCTA GTGGAGAAAT TGATAAAACG

AATCAATCGG CAGGAACACA ACCAAGTATT CCTATTGAAA CAAGCAACTT AGCGGAGGTA

ACACATGTAC CAAGTGAAAC TACTCCAATT ACAACAGAAG CTGGGGAAGA AATTGTAGCA

GTAGATAAAG GTGTTCCGTT AACCAAAACA CCAGAAGGAT TAAAACCAAT TAGCAGCTCG

TATAAGGTTT TACCTAGCGG AAACGTTGAG GTAAAAGCAA GTGATGGAAA AATGAAAGTA

TTGCCACATA CAGGAGAGAA ATTCACACTC CTTTTCTCTG TATTGGGAAG CTTCTTTGTA

TTAATTTCAG GATTCTTTTT CTTTAAAAAG AATAAGAAAA AAGCTTAA

EF054-2 (SEQ ID NO:202)

M KKIILSSLFS AVLVFGGGSI TAFADDLGPT DPATPPITEP TDSSEPTNPT

EPVDPAEPPV IPTDPTEPSK PTEPTTPSEP EKPTEPTTPI DPGTPVEPTE PSEPTEPSQP

TEPTTPSEPE KPVTPEQPKE PTQPVIPEKP AEPETPKTPE QPTKPIDVVV TPSGEIDKTN

QSAGTQPSIP IETSNLAEVT HVPSETTPIT TEAGEEIVAV DKGVPLTKTP EGLKPISSSY

KVLPSGNVEV KASDGKMKVL PHTGEKFTLL FSVLGSFFVL ISGFFFFKKN KKKA

EF054-3 (SEQ ID NO:203)

A

ACAGATCCAG CAACTCCACC AATTACCGAA CCAACTGATT CTAGTGAACC TACGAATCCT

ACTGAGCCGG TGGATCCTGC AGAACCGCCA GTAATACCAA CTGATCCAAC AGAACCAAGC

AAGCCAACCG AGCCTACAAC ACCGAGTGAC CCAGAAAAGC CAACAGAACC AACAACGCCA

ATTGATCCTG GAACGCCGGT TGAACCGACT GAACCAAGCG AGCCAACAGA ACCTAGTCAA

CCAACCGAGC CTACAACACC AAGCGAACCA GAAAAACCTG TTACTCCAGA ACAACCGAAA

CAACCAACTC AACCAGTGAT TCCAGAAAAA CCAGCAGAAC CAGAAACACC AAAAACTCCT

GAACAGCCCA CTAAACCAAT AGACGTAGTC GTTACACCTA GTGGAGAkAT TGATAAAACG

AATCAATCGG CAGGAACACA ACCAAGTATT CCTATTGAAA CAAGCAACTT AGCGGAGGTA

ACACATGTAC CAAGTGAAAC TACTCCAATT ACAACAGAAG CTGGGGAAGA AATTGTAGCA

GTAGATAAAG GTGTTCCGTT AACCAAAACA CCAGAAGGAT TAAAACCAAT TAGCAGCTCG

TATAAGGTTT TACCTAGCGG AAACGTTGAG GTAAAAGCAA GTGATGGAAA AATGAAAGTA

T

EF054-4 (SEQ ID NO:204)

DDLGPT DPATPPITEP TDSSEPTNPT

EPVDPAEPPV IPTDPTEPSK PTEPTTPSEP EKPTEPTTPI DPGTPVEPTE PSEPTEPSQP

TEPTTPSEPE KPVTPEQPKE PTQPVIPEKP AEPETPKTPE QPTKPIDVVV TPSGEIDKTN

QSAGTQPSTP IETSNLAEVT HVPSETTPIT TEAGEEIVAV DKGVPLTKTP EGLKPISSSY

KVLPSGNVEV KASDGKMKV

EF055-1 (SEQ ID NO:205)

TAACAAAAGG TTGTTTTGTC TTTCTTGTGT AAAAGGGCAA GAAAGGCTAG CGAGTTAAAA

GGAGGTTTTT CAATGAAAAA AAAGCGTTAT TTAATGATTG TGTGTCTACT ATCTTCTCCT

AGTTTTTTTA TAAATGTTGA AGCGTCTGAT GGTCGTTCTA GTTCGGTGGG GATTGAATTT

TACCAAAATC CGAGAACACC CGCTCCTAAA GATCCCCCAC CGAAAACAGA TGCGCCAGCT

GCTGATCCCA AGGAACCAGC TGGTCCTCCG CAAGGAGATC AACGAAGTGG TGGTTCGACA

CAGACCACCA CAACTGGCTC AACGCTCCCT CGTACAGGGA GCAAGAGTCA GGCAAATTTG

AGCATTCTCN GNTTCGCCTT AATCGGTTTG GCGGGAATCG TACATAGAAA GAAGGGACGA

CATGAAGCAA ACTAA

EF055-2 (SEQ ID NO:206)

MKKKRYL MIVCLLSSPS FFINVEASDG GSSSVGIEFY

QNPRTPAPKD PPPKTDAPAA DPKEPAGPPQ GDQRSGGSTQ TTTTGSTLPR TGSKSQANLS

ILXFALIGLA GIVHRKKGRH EAN

EF055-3 (SEQ ID NO:207)

AGCGTCTGAT GGTGGTTCTA GTTCGGTGGG CATTGAATTT

TACCAAAATC CGAGAACACC CGCTCCTAAA GATCCCCCAC CCAAAACAGA TGCGCCAGCT

GCTGATCCCA AGGAACCAGC TGGTCCTCCG CAAGGAGATC AACGAAGTGG TGGTTCGACA

CAGACCACCA CAACTCGCTC AACG

EE055-4 (SEQ ID NO:208)

SDG GSSSVGIEEY

QNPRTPAPKD PPPKTDAPAA DPKEPAGPPQ GDQRSGGSTQ TTTTGST

EF056-1 (SEQ ID NO:209)

TAAATGAAAA AAAAGCGTTA TTTAATAATT GCGTGTTTAC TATTTTCCCC TAGTTTTTTT

ATAAATGTTG AAGCATCTGA GGGTGGTTCT AGTTCGCTGG GAATTGAATT TTACCAAAAT

CCGGCAACAC CCGCTCCTAA AGATGCCCCA CCGAAAACAG ATGAGCCAGC TGCGGATCCC

AAGGAACCAG CTGGTCCTCT GCAAGGAGAT CAACGAAGTG GTGGTTCGAC ACAGACCACC

ACAGCTGGCT CGCAGCTCCC TCGTACAGGA AGCAAGAGTC AGGCAAACCT GAGCATTCTT

GGTCTTGTCT TGATTGGTCT TGTCGGAATG GTCCAGAGAA AGAAGGGACG ACATGAAGCA

AACTAA

EF056-2 (SEQ ID NO:210)

MKKKRYLIIA CLLFSPSFFI NVEASEGGSS SVGIEFYQNP ATPAPKDAPP KTDEPAADPK

EPAGPLQGDQ RSGGSTQTTT AGSQLPRTGS KSQANLSTLG LVLLGLVGMV QRKKGRHEAN

EF056-3 (SEQ ID NO:211)

ATCTGA GGGTC-GTTCT AGTTCGGTGG GAATTGAATT TTACCAAAAT

CCGGCAACAC CCGCTCCTAA AGATGCCCCA CCGAAAACAG ATGAGCCAGC TGCGGATCCC

AAGGAACCAG CTGGTCCTCT GCAAGGAGAT CAACGAAGTG GTGGTTCGAC ACAGACCACC

ACAGCTGGCT CGCAG

EF056-4 (SEQ ID NO:212)

SEGGSS SVGIEFYQNP ATPAPKDAPP KTDEPAADPK

EPAGPLQGDQ RSGGSTQTTT AGSQ

EF057-1 (SEQ ID NO:213)

TAATGTTTAT TGGCTGGCCC AGTCAATGTT GAAAATGGGG AAGCAGGAAT TCAGATGAAA

ATCATAAAAA GGTTTAGTTT GGTATGTTTA GGGCTATTGA TCATTGGGTT GCNAACAAAA

AGCGNTATGG CTGAAGAAAA TAATTATGAA TCAAATGGTC AAGCGAGCTT CTATGGTACC

TACGTTTATG AGAATGAAAA AGAGTCAAAT GACGTAGCGT ATACCCAACA ATCAGAAGAA

CAGGGAAGAA ACAATTTAGC TGCTTCTGGA CAAGCAGTTT TACCTAAAAC AGCCGAGTCT

GAAAATCCGC TGTATTCCTT GATAGGAGTT AGTTTGTTGG GGATAGTCAT TTATTTAATT

AATAAAATGA AACGAGAGAA GGAGTTTATT TAA

EF057-2 (SEQ ID NO:214)

MKI IKRFSLVCLG LLIIGLXTKS XMAEENNYES NGQASFYGTY

VYENEKESND VAYTQQSEEQ GRNNLAASGQ AVLPKTGESE NPLYSLIGVS LLGIVIYLIN

KMKREKEFI

EF057-3 (SEQ ID NO:215)

AAA TAATTATGAA TCAAATGGTC AAGCGAGCTT CTATGGTACC

TACGTTTATG AGAATGAAAA AGAGTCAAAT GACGTAGCGT ATACCCAACA ATCAGAAGAA

CAGGGAAGAA ACAATTTAGC TGCTTCTGGA CAAGCAGTTT

EF057-4 (SEQ ID NO:216)

EENNYES NGQASFYGTY

VYENEKESND VAYTQQSEEQ GRNNLAASGQ AV

EF058-1 (SEQ ID NO:217)

TGAAGAACGT TCTATTTGGT TGACGATTGC AGGCCTGCTA ATCATTGGGA TGCTAGTCAT

TTGGCTATTT TATCAAAAAC AAAAAAGAGG AGAGAGAAAA TGAAGCAATT AAAAAAAGTT

TGGTACACCG TTAGTACCTT GTTACTAATT TTGCCACTTT TCACAAGTGT ATTAGGGACA

ACAACTGCAT TTGCAGAAGA AAATGGGGAG AGCGCACAGC TCGTGATTCA CAAAAACAAA

ATGACGGATT TACCAGATCC GCTTATTCAA AATAGCGGGA AAGAAATGAG CGAGTTTGAT

AAATATCAAC GACTGGCAGA TGTGACGTTT AGTATTTATA ACGTGACGAA CGAATTTTAC

GAGCAACGAG CGGCAGGCGC AAGCGTTGAT GCAGCTAAAC AAGCTGTCCA AAGTTTAACT

CCTGGGAAAC CTGTTGCTCA AGOAACCACC GATGCAAATG GGAATGTCAC TGTTCAGTTA

CCTAAAAAAC AAAATGGTAA AGATGCAGTG TATACCATTA AAGAAGAACC AAAAGAGGGT

GTAGTTGCTG CTACGAATAT GGTGGTGGCG TTCCCAGTTT ACGAAATGAT CAAGCAAACA

GATGGTTCCT ATAAATATGG AACAGAAGAA TTAGCGGTTG TTCATATTTA TCCTAAAAAT

GTGGTAGCCA ATGATGGTAG TTTACATGTG AAAAAAGTAG GAACTGCTGA AAATGAAGGA

TTAAATGGCG CAGAATTTGT TATTTCTAAA AGCGAAGGCT CACCAGGCAC AGTAAAATAT

ATCCAAGGAG TCAAAGATGG ATTATATACA TGGACAACGG ATAAAGAACA AGCAAAACGC

TTTATTACTG GGAAAAGTTA TGAAATTGGC GAAAATGATT TCACAGAAGC AGAGAATGGA

ACGGGAGAAT TAACAGTTAA AAATCTTGAG GTTGGTTCGT ATATTTTAGA AGAAGTAAAA

GCTCCAAATA ATGCAGAATT AATTGAAAAT CAAACAAAAA CACCATTTAC AATTGAAGCA

AACAATCAAA CACCTGTTGA AAAAACAGTC AAAAATGATA CCTCTAAAGT TGATAAAACA

ACACCAAGCT TAGATGGTAA AGATGTGGCA ATTGGCGAAA AAATTAAATA TCAAATTTCT

GTAAATATTC CATTGGGGAT TGCAGACAAA GAAGGCGACG CTAATAAATA CGTCAAATTC

AATTTAGTTG ATAAACATGA TGCAGCCTTA ACTTTTGATA ACGTGACTTC TGGAGAGTAT

GCTTATGCGT TATATGATGG GGATACAGTG ATTGCTCCTG AAAATTATCA AGTGACTGAA

CAAGCAAATG GCTTCACTGT CGCCGTTAAT CCAGCGTATA TTCCTACGCT AACACCAGGC

GGCACACTAA AATTCGTTTA CTTTATGCAT TTAAATGAAA AAGCAGATCC TACGAAAGGC

TTTAAAAATG AGGCGAATGT TGATAACGGT CATACCGACG ACCAAACACC ACCAACTGTT

GAAGTTGTCA CAGGTGGGAA ACGTTTCATT AAAGTCGATG GCGATGTGAC AGCGACACAA

GCCTTGGCGG GAGCTTCCTT TGTCGTCCGT GATCAAAACA GCGACACAGC AAATTATTTG

AAAATCGATG AAACAACGAA AGCAGCAACT TGGGTCAAAA CAAAAGCTGA AGCAACTACT

TTTACAACAA CGGCTGATGG ATTAGTTGAT ATCACAGGGC TTAAATACGG TACCTATTAT

TTAGAAGAAA CTGTAGCTCC TGATGATTAT GTCTTGTTAA CAAATCGGAT TGAATTTGTG

GTCAATGAAC AATCATATGG CACAACAGAA AACCTAGTTT CACCAGAAAA AGTACCAAAC

AAACACAAAG GTACCTTACC TTCAACAGGT GGCAAAGGAA TCTACGTTTA CTTAGGAAGT

GGCGCAGTCT TGCTACTTAT TGCAGGAGTC TACTTTGCTA GACGTAGAAA AGAAAATGCT

TAA

EF058-2 (SEQ ID NO:218)

MKQLKKVW YTVSTLLLIL PLFTSVLGTT

TAFASENGES AQLVIHKKKM TDLPDPLIQN SGKEMSEFDK YQGLADVTFS IYNVTNEFYE

QRAAGASVDA AKQAVQSLTP GKPVAQGTTD ANGNVTVQLP KKQNGKDAVY TIKEEPKEGV

VAATNNVVAF PVYEMIKQTD GSYKYGTEEL AVVHIYPKNV VANDGSLHVK KVGTAENEGL

NGAEFVISKS EGSPGTVKYI QGVKDGLYTW TTDKEQAKRF ITGKSYEIGE NDFTEAENGT

GELTVKNLEV GSYILEEVKA PNNAELIENQ TKTPFTIEAN NQTPVEKTVK NDTSKVDKTT

PSLDGKDVAI GEKIKYQISV NIPLGIADKE GDANKYVKFN LVDKHDAALT FDNVTSGEYA

YALYDGDTVI APENYQVTEQ ANGFTVAVNP AYIPTLTPGG TLKFVYFMHL NEKADPTKGF

KNEANVDNGH TDDQTPPTVE VVTGGKRFIK VDGDVTATQA LAGASFVVRD QNSDTANYLK

IDETTKAATW VKTKAEATTF TTTADGLVDI TGLKYGTYYL EETVAPDDYV LLTNRIEFVV

NEQSYGTTEN LVSPEKVPNK HKGTLPSTGG KGIYVYLGSG AVLLLIAGVY FARRRKENA

EF058-3 (SEQ ID NO:219)

AGAAGA AAATGGGGAG AGCGCACAGC TCGTGATTCA CAAAAAGAAA

ATGACGGATT TACCAGATCC GCTTATTCAA AATAGCGGGA AAGAAATGAG CGAGTTTCAT

AAATATCAAG GACTGGCAGA TGTGACGTTT AGTATTTATA ACGTGACGAA CGAATTTTAC

GAGCAACGAG CGGCAGGCGC AAGCGTTCAT GCACCTAAAC AAGCTGTCCA AAGTTTAACT

CCTGGGAAAC CTGTTGCTCA AGGAACCACC GATGCAAATG GGAATGTCAC TGTTCAGTTA

CCTAAAAAAC AAAATGGTAA AGATGCAGTG TATACCATTA AAGAAGAACC AAAAGAGGGT

GTAGTTGCTG CTACGAATAT GGTGGTGGCG TTCCCAGTTT ACGAAATGAT CAAGCAAACA

GATOOTTOCT ATAAATATGG AACAGAAGAA TTAGCGGTTG TTCATATTTA TCCTAAAAAT

OTOCTAGOCA ATGATGGTAG TTTACATGTG AAAAAAGTAG GAACTGCTGA AAATGAAGGA

TTAAATGGCG CAGAATTTGT TATTTCTAAA ACCGAAGGCT CACCAGGCAC AGTAAAATAT

ATCCAAGGAG TCAAAGATGG ATTATATACA TGGACAACGG ATAAAGAACA AGCAAAACGC

TTTATTACTG GGAAAAGTTA TGAAATTGGC GAAAATGATT TCACAGAAGC AGAGAATGGA

ACGGGAGAAT TAACAGTTAA AAATCTTGAG GTTGGTTCGT ATATTTTAGA AGAAGTAAAA

GCTCCAAATA ATGCAGAATT AATTGAAAAT CAAACAAAAA CACCATTTAC AATTGAAGCA

AACAATCAAA CACCTGTTGA AAAAACAGTC AAAAATGATA CCTCTAAAGT TGATAAAACA

ACACCAAGCT TAGATGGTAA AGATGTGGCA ATTGGCGAAA AAATTAAATA TCAAATTTCT

GTAAATATTC CATTGGGGAT TGCAGACAAA GAAGGCGACG CTAATAAATA CGTCAAATTC

AATTTAGTTG ATAAACATGA TGCAGCCTTA ACTTTTGATA ACGTGACTTC TGGAGAGTAT

GCTTATGCGT TATATGATGG GGATACAGTG ATTGCTCCTG AAAATTATCA AGTGACTGAA

CAAGCAAATG GCTTCACTGT CGCCGTTAAT CCAGCGTATA TTCCTACGCT AACACCAGGC

GGCACACTAA AATTCGTTTA CTTTATGCAT TTAAATGAAA AAGCAGATCC TACGAAAGGC

TTTAAAAATG AGGCGAATGT TGATAACGGT CATACCGACG ACCAAACACC ACCAACTGTT

GAAGTTGTGA CAGGTGGGAA ACGTTTCATT AAAGTCGATG GCGATGTGAC AGCGACACAA

GCCTTGGCGG GAGCTTCCTT TCTCGTCCCT GATCAAAACA GCGACACAGC AAATTATTTG

AAAATCGATG AAACAACCAA AGCAGCAACT TGGGTGAAAA CAAAAGCTGA AGCAACTACT

TTTACAACAA CGGCTGATGG ATTAGTTGAT ATCACAGGGC TTAAATACGG TACCTATTAT

TTAGAAGAAA CTGTAGCTCC TGATGATTAT GTCTTGTTAA CAAATCGGAT TGAATTTGTG

GTCAATGAAC AATCATATGG CACAACAGAA AACCTAGTTT CACCAGAAAA AGTACCAAAC

AAACACAAAG GTACCTTACC T

EF058-4 (SEQ ID NO:220)

FENGES AQLVIHKKKM TDLPDPLJIQN SGKENSEFDK YQGLADVTFS IYNVTNEFYE

QEAAGASVDA AKQAVQSLTF GKPVAQGTTD ANGNVTVQLP KKQNGKDAVY TIKEEPKEGV

VAATNMVVAF PVYEMIKQTD GSYKYGTEEL AVVHIYPKNV VANDGSLHVK KVGTAENEGL

NGAEFVISKS EGSPGTVKYI QGVKDGLYTW TTDKEQAKRF ITGKSYEIGE NDFTEAENGT

GELTVKNLEV GSYILEEVKA PNNAELIENQ TKTPFTIEAN NQTPVEKTVK NDTSKVDKTT

PSLDGKDVAI GEKIKYQISV NTPLGIADKE GDANKYVKFN LVDKHDAALT FDNVTSGEYA

YALYDGDTVI APENYQVTEQ ANGFTVAVNP AYIPTLTFGG TLKFVYFMHL NEKADPTKGF

KNEANVDNGH TDDQTPPTVE VVTGGKRFIK VDGDVTATQA LAGASFVVRD QNSDTANYLK

IDETTKAATW VKTKAEATTF TTTADGLVDT TGLKYGTYYL EETVAPDDYV LLTNRTEFVV

NEQSYGTTEN LVSPEKVPNK HKGT

FF059-1 (SEQ ID NO:221)

TAGATTGGAA GAATGAAAAT GAAAAAAATG ATTATTATTG CCTTATTCAG TACAAGCCTT

TTAGCAGGGG GAAGCAGTGT TTCTGCTTAT GCGCAAGAAT CAGAAGGAAA TCTTGGTGAA

ACAACAGGGA GTGTTTTACC AGATGAACCG AATGTACCAA CTGACCCAAT AACGCCAAGT

GAGCCAGAGC AACCAACAGA GCCAAGTACA CCAGAGCAAC CATCGGAACC GTCAACACCA

ACCGAACCTA GTGAGCCTTC AAAACCGACG GATCCTTCGT TACCAGACGA ACCGAGCGTA

CCAACAGAGC CAACAACGCC AAGTAAGCCA GAGCAACCAA CAGAGCCAAC AACGCCAAGT

GTACCAGAGC AACCAACAGA GCCAAGTGTA CCAGAAAAAC CAGTAGAACC AAATAAACCA

ACCGAGCCAG AAAAGCCTGT GCCAGTTGTT CCTGAAAAAC CAGTTGTACC ACAACAACCA

GAGCAACCAA CAGATGTGGT GGTAAAGCCA AATGGAGAAA TTGCAACAGG AGAATCTACA

CAACAGCCAA CTGTTCCAAT TGAAACGAAT AACCTTTCAG AAGTAACACA TGTCCCAACT

GTGACGACAC CGATTGAAAC AGCAAGCGGA GAAGCAATTG TCGCAGTGGA TAAGGGCGTT

CCTTTAACAC AAACGGCTGA TGGATTAAAA CCGATTAAAA GTGAATATAA AGTATTACCA

AGTGGCAATG TACAAGTGAA AAGTGCTGAC GGAAAAATGA AAGTACTTCC TTACACTGGT

GAAAAAATGG GCATAATTGG GTCAATCCCT GGTGTATGTT TGACTGTTTT ATCAGGAATC

TTAATTTATA AAAAACGTAA AGTGTAG

EF059-2 (SEQ ID NO:222)

MKKMI IIALFSTSLL AGGSSVSAYA QESEGNLGET TGSVLPDEPN VPTDPITPSE

PEQPTEPSTP EQPSEPSTPT EPSEPSKPTD PSLPDEPSVP TEPTTPSKPE QPTEPTTPSV

PEQPTEPSVP EKPVEPNKPT EPEKPVPVVP EKPVVPQQPE QPTDVVVKPN GEIATGESTQ

QPTVPIETNN LSEVTHVPTV TTPIETASGE AIVAVDKGVP LTQTADGLKP IKSEYKVLPS

GNVQVKSADC KMKVLPYTGE KMGIIGSIAG VCLTVLSGIL IYKKRKV

EF059-3 (SEQ ID NO:223)

AGAAGGAAA TCTTGGTGAA

ACAACAGGGA GTGTTTTACC AGATGAACCG AATGTACCAA CTGACCCAAT AACGCCAAGT

GAGCCAGAGC AACCAACAGA GCCAAGTACA CCAGAGCAAC CATCGGAACC GTCAACACCA

ACCGAACCTA GTGAGCCTTC AAAACCGACG GATCCTTCGT TACCAGACGA ACCGAGCGTA

CCAACAGACC CAACAACGCC AAGTAAGCCA GAGCAACCAA CAGAGCCAAC AACGCCAAGT

GTACCAGAGC AACCAACAGA GCCAACTGTA CCAGAAAAAC CACTAGAACC AAATAAACCA

ACCGAGCCAG AAAAGCCTGT GCCAGTTGTT CCTGAAAAAC CAGTTGTACC ACAACAACCA

GAGCAACCAA CAGATGTGGT CGTAAAGCCA AATGGAGAAA TTGCAACAGG AGAATCTACA

CAACAGCCAA CTGTTCCAAT TGAAACGAAT AACCTTTCAG AAGTAACACA TGTCCCAACT

GTGACGACAC CGATTGAAAC AGCAAGCGGA GAAGCAATTG TCGCAGTGGA TAAGGGCGTT

CCTTTAACAC AAACGGCTGA TGGATTAAAA CCGATTAAAA GTGAATATAA AGTATTACCA

AGTGGCAATG TACAAGTGAA AAGTGCTGAC GGAAAAATGA AAGTAC

EF059-4 (SEQ ID NO:224)

EGNLGET TGSVLPDEPN VPTDPITPSE

PEQPTEPSTP EQPSEPSTPT EPSEPSKPTD PSLPDEPSVP TEPTTPSKPE QPTEPTTPSV

PEQPTEPSVP EKPVEPNKPT EPEKPVPVVP EKPVVPQQPE QPTDVVVKPN GEIATGESTQ

QPTVPIETNN LSEVTHVPTV TTPIETASGE AIVAVDKGVP LTQTADGLKP IKSEYKVLPS

GNVQVKSADG KNKV

EF060-1 (SEQ ID NO:225)

TGAAAAATAG ACAAGGAGCA CGCGATGATG ACAATGAAAA GTAAAGGGTC ACTTCTGGTG

ACGTTGGGAA TACTTTTAAC CGTTGGCATT GCGAGTCTAA TTGTTTCTTC TGAGAGTTTT

GCAGAAGAAG TAGGGCAAAC GAATATCGGT GTAACGTTCT ATGGAGGAAA AGAGCCACTA

AAAACGGAAG CTGTCATTAA GCCAATAGAG CAACCAGTCA CTC-ATAAAGA TAAAAAAACG

TCACAACAAC AAGACAAAGT GAGCAGAAAA ACCACTGCTA AAACGAATCC GACTAATGCA

CAGACGTCAT TACCAAGGAC AGGTGAACGA AATAGCACGT GGCTTTACAG CCTTGGTATT

GCCTGTTTAC TCGTAGTACT AACAAGTTTC TATTATTTGA ATAAAAAAAG GAAAAAGGAA

AAATAA

EF060-2 (SEQ ID NO:226)

MMT MKSKGSLLVT LGILLTVGIA SLIVSSESFA EEVGQTNIGV TFYGGKEPLK

TEGVIKPIEQ PVTDKDKKTS QQQDKVSRKT TAKTNPTNAQ TSLPRTGERN STWLYSLGIA

CLLVVLTSFY YLNKKRKKEK

EF060-3 (SEQ ID NO:227)

AGAAGAAG TAGCGCAAAC CAATATCGGT GTAACGTTCT ATGGAGCAAA AGAGCCACTA

AAAACGGAAG GTGTCATTAA GCCAATAGAG CAACCAGTCA CTGATAAAGA TAAAAAAACG

TCACAACAAC AAGACAAAGT GAGCAGAAAA ACCACTGCTA AAACGAATCC GACTAATGCA

CAGACCTCAT

EE060-4 (SEQ ID NO:228)

EEVGQTNIGV TFYGGKEPLK

TEGVIKPIEQ PVTDKDKKTS QQQDKVSRKT TAKTNPTNAQ TS

EF061-1 (SEQ ID NO:229)

TAATGGAACG ACCCACAGAA GAAGATTTTG AACTTACAAA TTAAAATTAA AATGGAGGAA

ATAATGATGA AAAAAATTCT TTTTGCTAGT TTATTTAGTG CCACACTACT ATTTGGGGGA

AGTGAAATTT CTGCTTTTGC ACAAGAAATT ATCCCTGATG ATACTACGAC ACCGCCCATT

GAAGTACCAA CACAACCAAG TACACCAGAA AAGCCAACAG ATCCAACACC GCCAATTGAG

CCACCTGTAG ACCCTGTAGA GCCACCTATT ACACCAACGG AGCCAACAGA ACCGACAGAG

CCGACAACAC CAACAGAACC TACAACTCCT ACAGAGCCAA GTGAACCAGA ACAACCAACG

GAGCCAAGTA AACCAGTAGA ACCTGAAAAA CCAGTTACAC CAAGCAAACC AGCAGAACCC

GAAAAAACTG TGACACCAAC TAAACCAACA GAATCTGAAA AACCAGTACA ACCAGCAGAA

CCAAGCAAGC CAATCGACGT TGTTGTAACG CCAACAGGGG AATTAAATCA CGCTGGAAAT

GGTACACAAC AGCCAACAGT CCCTATTGAA ACAAGTAATT TGGCAGAAAT CACGCACGTG

CCTAGTGTAA CAACACCTAT TACAACTACA GACGGAGAAA ACATTGTAGC TGTAGAAAAA

GGTCTTCCAC TTACACAAAC AGCAGAAGGG TTAAAACCTA TTCAATCNAG TTACAAAGTA

TTGCCTAGCG GAAATGTAGA AGTAAAAGGT AAGGACGGTA AAATGAAGGT TTTACCATAC

ACAGGTGAAC AAATGAATAT CTTTTTATCT GCCGTAGCGG TATCTTGTCT GTAG

EF061-2 (SEQ ID 140:230)

MKKKTLFASL FSATLLFGGS EISAFAQEII PDDTTTPPIE

VPTEPSTPEK PTDPTPPIEP PVDPVEPPIT PTEPTEPTEP TTPTEPTTPT EPSEPEQPTE

PSKPVEPEKP VTPSKPAEPE KTVTPTKPTE SEKPVQPAEP SKPIDVVVTP TGELNHAGNG

TQQPTVPIET SNLAEITHVP SVTTPITTTD GENIVAVEKO VPLTQTAEGL KPIQSSYKVL

PSGNVEVKGK DGKNKVLPYT GEEMNIELSA VAVSCL

EF061-3 (SEQ ID 140:231)

GAAATTT CTGCTTTTGC ACAAGAAATT ATCCCTGATG ATACTAGGAC ACCGCCCATT

GAAGTACCAA CAGAACCAAG TACACCAGAA AAGCCAACAG ATCCAACACC GCCAATTGAG

CCACCTGTAG ACCCTGTAGA GCCACCTATT ACACCAACGG AGCCAACAGA ACOGACACAG

CCGACAACAC CAACAGAACC TACAACTCCT ACAGAGCCAA GTGAACCAGA ACAACCAACG

GAGCCAAGTA AACCAGTAGA ACCTGAAAAA CCAGTTACAC CAAGCAAACC AGCAGAACCC

GAAAAAACTG TGACACCAAC TAAACCAACA GAATCTGAAA AACCAGTACA ACCAGCAGAA

CCAAGCAAGC CAATCGACGT TGTTGTAACG CCAACAGGGG AATTAAATCA CGCTGGAAAT

GGTACACAAC AGCCAACAGT CCCTATTGAA ACAAGTAATT TGGCAGAAAT CACGCACGTG

CCTAGTGTAA CAACACCTAT TACAACTACA GACGGAGAAA ACATTGTAGC TGTAGAAAAA

GGTGTTCCAC TTACACAAAC AGCAGAAGGG TTAAAACCTA TTCAATCNAG TTACAAAGTA

TTGCCTAGCG GAAATGTAGA AGTAAAAGGT AAGGACGGTA AAATGAAGGT TT

EF061-4 (SEQ ID NO:232)

QEII PDDTTTPPIE

VPTEPSTPEK PTDPTPPIEP PVDPVEPPIT PTEPTEPTEP TTPTEPTTPT EPSEPEQPTE

PSKPVEPEKP VTPSKPAEPE KTVTPTKPTE SEKPVQPAEP SKPIDVVVTP TGELNHAGNG

TQQPTVPIET SNLAEITHVP SVTTPTTTTD GENIVAVEKG VPLTQTAEGL KPIQSSYKVL

PSGNVEVKGK DGKMKV

EF062-1 (SEQ ID NO:233)

TGATTCTTGA AGCAACAAAT GAAAGCAAAA AAACAATATA AGACATATAA AGCTAAGAAT

CACTGGGTAA CTGTCCCTAT TCTTTTTCTA AGTGTGTTAG GAGCCGTAGG ATTAGCTACT

GATAATGTAC AAGCCGCGGA ATTAGATACG CAACCAGAAA CAACGACGGT TCAACCCAAT

AACCCCGACC TGCAGTCAGA AAAGGAAACA CCTAAAACGG CAGTATCTGA AGAAGCAACA

GTACAAAAAG ACACTACTTC TCAACCGACC AAAGTAGAAG AAGTAGCGCC AGAAAATAAA

GGTACTGAAC AAAGTTCAGC TACCCCAAAT GATACCACAA ACGCGCAACA ACCAACAGTA

GGACCTGAAA AATCAGCACA AGAACAACCA GTAGTAAGCC CTGAAACAAC CAATGAACCT

CTAGGGCACC CAACAGAAGT TGCACCAGCT GAAAATGAAG TGAATAAATC AACGTCCATT

CCTAAAGAAT TTGAAACACC AGACGTTGAT AAAGCAGTTG ATGAAGTAAA AAAAGATCCA

AACATTACCG TTGTTGAAAA ACCAGCAGAA GACTTAGGCA ACGTTTCTTC TAAAGATTTA

GCTGCAAAAG AAAAAGAAGT AGACCAACTA CAAAAAGAAC AAGCGAAAAA GATTCCCCAA

CAAGCAGCTG AATTAAAAGC CAAAAATGAA AAAATTGCCA AAGAAAATGC AGAAATTGCG

GCAAAAAACA AAGCNGAAAA AGAGCGNTAN GANAAAGAAG TCGCNGAATA CAACAAGCAT

AAGAACGAAA ACAGCTATGT CAATGAAGCG ATTAGTAAAA ACCTAGTGTT CGATCAATCT

GTCGTGACGA AAGACACTAA AATTTCGTCG ATTAAAGGCG GAAAATTTAT CAAAGCAACT

GATTTTAATA AAGTAAATGC AGGGGATTCA AAAGATATCT TTACAAAATT ACGGAAAGAT

ATGGGNGGGA AAGNTACTGG CAACTTCCAG AATTCCTTTG TAAAAGAGGC AAATCTTGGG

TCTAATGGTG GGTATGCGGT TCTTTTAGAA AAAAATAAAC CAGTGACACT GACCTATACA

GGACTAAACG CTAGTTATTT AGGACGTAAA ATTACAAAAG CAGAATTTGT TTATGAACTA

CAATCCTCAC CAAGCCAAAG TGGAACGTTA AATGCAGTAT TTTCAAACGA TCCGATTATC

ACNGCTTTTA TTGGTACAAA CAGAGTCAAT GGTAAGGATG TTAAAACACG CTTAACGATT

AAGTTCTTTG ATGCGTCAGG TAAAGAAGTA CTACCAGATA AAGATAGTCC ATTTGCGTAT

GCGCTGTCTT CTTTAAATTC AAGTTTAACG AATAAAGGTG GCCATGCGGA ATTTGTTTCT

GATTTTGGGG CNAACAATGC GTTCAAATAC ATTAATGGNT CNTATGTGAA AAAACAAGCG

GATGGAAAAT TTTACTCACC GGAAGATATT GACTATGGCA CAGGACCTTC TGGATTGAAA

AATAGTGATT GGGACGCTGT AGGTCACAAG AATGCCTACT TTGGTTCAGG TGTAGGTCTA

GCNAATGGNC GTATTTCCTT TTCTTTTGGT ATGACAACAA AAGGAAAAAG TAATGTGCCT

GTATCTAGTG CGCAATGGTT TGCCTTTAGN ACTAACTTAA ATGCGCAATC AGTGAAGCCT

ATTTTCAATT ATGGGAATCC AAAAGAACCA GAAAAAGCAA CGATTGAATT CAATNGATAC

AAAGCCAATG TCGTTCCTGT NCTTGTGCCN AATAAAGAAG TCACTCATGG NCAGAAAAAT

NTCAATGATT TAAATGTGAA NCGTGGCGAT TCTTTACAAT ACATTGTGAC AGGGGATACG

ACAGAACTTG CCAAAGTAGA TCCAAAAACA GTAACNAAAC AAGGGATTCG AGATACNTTT

GATGCAGAAA AACTGACGAT TGATTTATCC AAAGTGAAAG TTTATCAAGC AGACGCAAGT

CTNAACGANA AAGACTNAAA AGCTGTTGCT GCAGCNATTA ATTCAGGAAN AGCTAAAGAC

GTGACTGCTT CTTATGANCT CAATTTAGAT CAAAACACCG TCACAGCAAT GATGAAAACC

AACGCNGACG GNTCNGTTGT TTTAGCAATG GGGTATAAAT ATTTACTTGT CTTGCCGTTT

GTAGTGAAAA ATGTAGAAGG CGATTTTGAA AATACAGCTG TTCAGCTGAC AAANGATGGN

GAAACGGTAA CAAATACAGT GATTAACCAT GTGCCAGGTA GTAATCCTTC CAAAGATGTA

AAAGCAGATA AAAACGGTAC AGTTGGCAGT GTTTCTCTAC ATGATAAAGA TATTCCGTTA

CAAACAAAAA TTTATTATGA AGTGAAATCT TCCGAACGTC CAGCNAACTA TGGCGGAATN

ACNGAAGAAT GGGGCATGAA TGATGTCTTG GACACGACCC ATGATCGTTT CACAGGNAAA

TGGCACGCTA TTACNAANTA TGACCTTAAA GTAGGGGANA AAACGTTAAA AGCAGGAACA

GATATTTCTG CCTACATTCT TTTAGAAAAC AAAGACAATA AAGACTTGAC GTTTACNATG

AATCAAGCAT TATTGGCNGC NTTAAATGAA GGAAGCAATA AAGTAGGCAA ACAAGCTTGG

TCTGTGTATC TGCAACTCGA ACGGATNAAA ACAGOTOACO TAGAAAACAC GCAAACAGAA

AACTACAACA AAGAGCTTGT NCGTTCTAAT ACNGTCCTCA CGCATACNCC TGATGATCCA

AAACCAACCA AAGCCGTTCA TAACAAGAAA CGGGAACANA TTAANCATGG AAAAGTNGCT

CGTGGTGATG TTCTTTCTTA TGAAATGACN TGGGACTTAA AAGGGTACGA TAAAGACTTT

GCCTTTGATA CACTOGATOT TOCCACAGOC GTTTCTTTCT TCGATGATTA CGATGAAACG

AANGTGACAC CAATCAAAGA CTTACTTCGT GTCAAAGATT CTAAAGGGGN AGACATTACO

AACCAGTTCA CGATCTCNTG GGACGATGCC AAAGGCACGG TGACNATNTC TGCCAAAGAC

CCACAAGCCT TTATTCTAGC GNATGGTGGG CAAGAATTGC GTGTAACNCT CCCTACAAAA

GTCAAAGCCG ATGTTTCTGG NGATGTTTAT AATTCAGCGG AACAAAATAC ATTTGGNCAA

CGAATTAAAA CCAATACNGT TGTCAACCAT ATTCCAAAAG TGAANCCTAA AAAAGACGTG

GTTATTAAAG TNGGTGACAA ACAAAGTCAA AATGGNGCCA CAATCAAATT AGGGGAGAAN

TTCTTCTATG AATTTACAAG TAGTGACATT CCTCCAGAAT ACGCTGGNGT TGTGGAAGAA

TGGTCGATTA GCGATAAACT AGACGTCAAA CATGACAAAT TTAGTGGCCA ATGGTCTGTG

TTTGCCAATT CTAATTTTGT TTTAGCAGAC GGAACCAAAG TGAATAAAGG GGACGACATT

TCGAAACTAT TCACGATGAC CTTTGAACAA GGGGTAGTGA AAATCACGGC CAGTCAAGCC

TTTTTNGATG CGATGAATCT AAAAGAAAAC AAAAACGTTC CACACTCATG GAAAGCGTTC

ATTGGTGTAG AACGAATTGC GGCAGGAGAC GTTTACAACA CAATCGAAGA ATCTTTCAAC

AATGAGAAGA TTAAAACNAA TACGGTAGTG ACNCATACGC CAGAAAAACC ACAAACNCCA

CCAGAAAAAA CAGTCATTGT ACCACCAACA CCAAAAACAC CGCAAGCACC ACTAGAGOCA

TTAGTGGTAG AAAAGGCAAG TGTNGTGCCA GAATTGCCGC AAACAGGCGA AAAACAAAAT

GTCTTATTAA CGGTAGCTGG TAGTTTAGCC GCAATGCTTG GCTTAGCAGG CTTAGGCTTT

AAACGTAGAA AAGAAACAAA ATAA

EF062-2 (SEQ ID NO:234)

MKAKK QYKTYKAKNH WVTVPILFLS VLCAVGLATD NVQAAELDTQ PETTTVQPNN

PDLQSEKETP KTAVSEEATV QKDTTSQPTK VEEVAPENKG TEQSSATPND TTNAQQPTVG

AEKSAQEQPV VSPETTNEPL GQPTEVAPAE NEVNKSTSIP KEFETPDVDK AVDEVKKDPN

ITVVEKPAED LGNVSSKDLA AKEKEVDQLQ KEQAKKIAQQ AAELKAKNEK IAKENAEILAA

KNKAEKERXX KEVAEYNKHK NENSYVNEAI SKNLVFDQSV VTKDTKISSI KGGKFIKATD

FNKVNAGDSK DIFTKLRKDM GGKXTGNFQN SFVKEANLGS NGGYAVLLEK NKPVTVTYTG

LNASYLGRKI TKAEFVYELQ SSPSQSGTLN AVFSNDPIIT AFIGTNRVNG KDVKTRLTIK

FFDASGKEVL PDKDSPFAYA LSSLNSSLTN KGGHAEFVSD FGANNAFKYI NGSYVKKQAD

GKFYSPEDTD YGTGPSGLKN SDWDAVGHKN AYFGSGVGLA NGRISFSFGM TTKGKSNVPV

SSAQWFAFXT NLNAQSVKPI FNYGNPKEPE KATIEFNXYK ANVVPVLVPN KEVTDGQKNX

NDLNVXRGDS LQYIVTGDTT ELAKVDPKTV TKQGIRDTFD AEKVTIDLSK TKVYQADASL

NXKDXKAVAA AINSGXAKDV TASYXLNLDQ NTVTAMMKTN ADGSVVLANG YKYLLVLPFV

VKNVEGDFEN TAVQLTXDGE TVTNTVINHV PGSNPSKDVK ADKNGTVGSV SLHDKDIPLQ

TKIYYEVKSS ERPANYGGXT EEWGMNDVLD TTHDRFTGKW HATTXYDLKV GXKTLKAGTD

ISAYILLENK DNKDLTFTNN QALLAALNEG SNKVGKQAWS VYLEVERXKT GDVENTQTEN

YNKELVRSNT VVTHTPDDPK PTKAVHNKKG EXIXHGKVAR GDVLSYEMTW DLKGYDKDFA

FDTVDLATGV SFFDDYDETX VTPIKDLLRV KDSKGXDTTN QFTISWDDAK GTVTXSAKDP

QAFILAXGGQ ELRVTLPTKV KADVSGDVYN SAEQNTFGQR IKTNTVVNHI PKVXPKKDVV

IKVGDKQSQN GATIKLGEXF FYEFTSSDTP AEYAGVVEEW SISDKLDVYH DKFSGQWSVF

ANSNFVLADG TKVNKGDDIS KLFTMTFEQG VVKITASQAF XDAMNLKENK NVAHSWKAFI

GVERIAAGDV YNTIEESFNN EKIKTNTVVT HTPEKPQTPP EKTVIVPPTP KTPQAPVEPL

VVEKASVVPE LPQTGEKQNV LLTVAGSLAA MLGLAGLGFK RRKETK

EF062-3 (SEQ ID NO:235)

TGATTCTTGA AGCAACAAAT GAAAGCAAAA AAACAATATA AGACATATAA AGCTAAGAAT

CACTGGGTAA CTGTCCCTAT TCTTTTTCTA AGTGTGTTAG GAGCCGTAGG ATTAGCTACT

GATAATGTAC AAGCCGCGCA ATTAGATACG CAACCAGAAA CAACGACGGT TCAACCCAAT

AACCCCGACC TGCAGTCAGA AAAGGAAACA CCTAAAACGG CAGTATCTGA AGAAGCAACA

GTACAAAAAG ACACTACTTC TCAACCGACC AAAGTAGAAG AAGTAGCGCC AGAAAATAAA

GGTACTGAAC AAAGTTCAGC TACCCCAAAT GATACCACAA ACGCGCAACA ACCAACAGTA

GGAGCTGAAA AATCAGCACA AGAACAACCA GTAGTAAGCC CTGAAACAAC CAATGAACCT

CTAGGGCAGC CAACAGAAGT TGCACCAGCT GAAAATGAAG TGAATAAATC AACGTCCATT

CCTAAAGAAT TTGAAACACC AGACGTTGAT AAAGCAGTTG ATCAAGTAAA AAAAGATCCA

AACATTACCG TTGTTGAAAA ACCAGCAGAA GACTTAGGCA ACGTTTCTTC TAAAGATTTA

GCTGCAAAAG AAAAAGAAGT AGACCAACTA CAAAAAGAAC AAGCGAAAAA CATTGCCCAA

CAAGCAGCTG AATTAAAAGC CAAAAATGAA AAAATTGCCA AAGAAAATGC AGAAATTGCG

GCAAAAAACA AAGCNGAAAA AGAGCGNTAN CANAAAGAAG TCGCNGAATA CAACAAGCAT

AAGAACGAAA ACAGCTATCT CAATGAAGCG ATTAGTAAAA ACCTAGTGTT CGATCAATCT

GTCGTGACGA AAGACACTAA AATTTCGTCG ATTAAACGCG GAAAATTTAT CAAAGCAACT

GATTTTAATA AAGTAAATGC AGGGGATTCA AAAGATATCT TTACAAAATT ACGGAAAGAT

ATGGGNGGGA AAGNTACTGG CAACTTCCAG AATTCCTTTG TAAAAGAGGC AAATCTTGGG

TCTAATGGTG GGTATGCGGT TCTTTTAGAA AAAAATAAAC CAGTGACAGT GACCTATACA

GGACTAAACG CTAGTTATTT AGGACGTAAA ATTACAAAAG CAGAATTTGT TTATGAACTA

CAATCCTCAC CAAGCCAAAG TGGAACGTTA AATGCAGTAT TTTCAAACGA TCCGATTATC

ACNGCTTTTA TTGGTACAAA CAGAGTCAAT GGTAAGGATG TTAAAACACG CTTAACGATT

AAGTTCTTTG ATGCGTCAGG TAAAGAAGTA CTACCAGATA AAGATAGTCC ATTTGCGTAT

GCGCTGTCTT CTTTAAATTC AAGTTTAACG AATAAAGGTG GCCATGCGGA ATTTGTTTCT

GATTTTGGGG CNAACAATGC GTTCAAATAC ATTAATGGNT CNTATGTGAA AAAACAAGCG

GATGGAAAAT TTTACTCACC GGAAGATATT GACTATGCCA CACGACCTTC TGGATTGAAA

AATAGTGATT GGGACGCTGT AGGTCACAAG AATGCCTACT TTGGTTCAGG TGTAGGTCTA

GCNAATGGNC GTATTTCCTT TTCTTTTGGT ATGACAACAA AAGGAAAAAG TAATGTCCCT

GTATCTAGTG CGCAATGGTT TGCCTTTAGN ACTAACTTAA ATGCGCAATC AGTGAAGCCT

ATTTTCAATT ATGGGAATCC AAAAGAACCA GAAAAAGCAA CGATTGAATT CAATNGATAC

AAAGCCAATG TCGTTCCTGT NCTTGTGCCN AATAAAGAAG TCACTGATGG NCAGAAAAAT

NTCAATGATT TAAATGTGAA NCGTGGCGAT TCTTTACAAT ACATTGTGAC AGGGGATACG

ACAGAACTTC CCAAAGTAGA TCCAAAAACA GTAACNAAAC AAGGGATTCG AGATACNTTT

GATGCAGAAA AAGTGACGAT TGATTTATCC AAAGTGAAAG TTTATCAAGC AGACGCAAGT

CTNAACGANA AAGACTNAAA ACCTGTTGCT GCAGCNATTA ATTCAGGAAN AGCTAAAGAC

GTGACTGCTT CTTATGANCT CAATTTAGAT CAAAACACCG TCACAGCAAT GATGAAAACC

AACGCNGACG GNTCNGTTGT TTTAGCAATG GGGTATAAAT ATTTACTTGT CTTGCCGTTT

GTAGTGAAAA ATGTAGAAGG CGATTTTGAA AATACAGCTG TTCAGCTGAC AAANGATGGN

GAAACGGTAA CAAATACAGT GATTAACCAT GTGCCAGGTA GTAATCCTTC CAAAGATGTA

AAAGCAGATA AAAACGGTAC AGTTGGCAGT GTTTCTCTAC ATGATAAAGA TATTCCGTTA

CAAACAAAAA TTTATTATGA AGTGAAATCT TCCGAACGTC CAGCNAACTA TGGCGGAATN

ACNGAAGAAT GGGGCATGAA TGATGTCTTG GACACGACCC ATGATCGTTT CACAGGNAAA

TGGCACGCTA TTACNAANTA TGACCTTAAA GTAGGGGANA AAACGTTAAA AGCAGGAACA

GATATTTCTG CCTACATTCT TTTAGAAAAC AAAGACAATA AAGACTTGAC GTTTACNATG

AATCAAGCAT TATTGGCNGC NTTAAATGAA GGAAGCAATA AAGTAGGCAA ACAAGCTTGG

TCTGTGTATC TGGAAGTCGA ACGGATNAAA ACAGGTGACG TAGAAAACAC GCAAACAGAA

AACTACAACA AAGAGCTTGT NCGTTCTAAT ACNGTGGTGA CGCATACNCC TGATGATCCA

AAACCAACCA AAGCCGTTCA TAACAAGAAA GGGGAAGANA TTAANCATCG AAAAGTNGCT

CGTGGTGATG TTCTTTCTTA TGAAATGACN TGGGACTTAA AAGGGTACGA TAAAGACTTT

GCCTTTGATA CAGTCGATCT TGCGACAGGC GTTTCTTTCT TCGATGATTA CGATGAAACG

AANGTGACAC CAATCAAAGA CTTACTTCGT GTCAAAGATT CTAAAGGGGN AGACATTACG

AACCAGTTCA CGATCTCNTG GGACGATGCC AAAGGCACCG TGACNATNTC TGCCAAAGAC

CCACAAGCCT TTATTCTAGC GNATGGTGGG CAAGAATTGC GTGTAACNCT CCCTACAAAA

GTCAAAGCCG ATGTTTCTGG NGATGTTTAT AATTCAGCGG AACAAAATAC ATTTGGNCAA

CGAATTAAAA CCAATACNGT TGTCAACCAT ATTCCAAAAG TGAANCCTAA AAAAGACGTG

GTTATTAAAG TNGGTGACAA ACAAAGTCAA AATGGNGCCA CAATCAAATT AGGGGAGAAN

TTCTTCTATG AATTTACAAG TAGTGACATT CCTGCAGAAT ACGCTGGNGT TGTGGAAGAA

TCGTCGATTA GCGATAAACT AGACGTCAAA CATGACAAAT TTAGTGGCCA ATGGTCTGTG

TTTGCCAATT CTAATTTTGT TTTAGCAGAC GGAACCAAAG TGAATAAAGC GGACCACATT

TCGAAACTAT TCACGATGAC CTTTGAACAA GGGGTAGTGA AAATCACGGC CAGTCAAGCC

TTTTTNGATG CGATGAATCT AAAAGAAAAC AAAAACGTTG CACACTCATG GAAAGCGTTC

ATTGGTGTAC AACGAATTGC GOCAGGAGAC GTTTACAACA CAATCGAAGA ATCTTTCAAC

AATGAGAAGA TTAAAACNAA TACGGTAGTG ACNCATACCC CAGAAAAACC ACAAACNCCA

CCAGAAAAAA CAGTGATTGT ACCACCAACA CCAAAAACAC CGCAAGCACC AGTAGAGCCA

TTAGTGGTAG AAAAGGCAAC TG

EF062-4 (SEQ ID NO:236)

AELDTQ PETTTPVQPNN

PDLQSEKETP KTAVSEEATV QKDTTSQPTK VEEVAPENKC TEQSSATPND TTNAQQPTVG

AEKSAQEQPV VSPETTNEPL GQPTEVAPAE NEVNKSTSIP KEFETPDVDK AVDEVKKDPN

ITVVEKPAED LGNVSSKDLA AKEKEVDQLQ KEQAKKIAQQ AAELKAKNEK IAKENAEIAA

KNKAEKERXX KEVAEYNKHK NENSYVNEAI SKNLVFDQSV VTKDTKISSI KGGKFIKATD

ENKVNAGDSK DIFTKLRKDM GGKXTGNFQN SFVKEANLGS NGGYAVLLEK NKPVTVTYTG

LNASYLGRKI TKAEFVYELQ SSPSQSGTLN AVFSNDPIIT AFIGTNRVNG KDVKTRLTIK

FFDASGKEVL PDKDSPEAYA LSSLNSSLTN KGGHAEEVSD FGANNAFKYI NGSYVKKQAD

GKFYSPEDID YGTGPSGLKN SDWDAVGHKN AYFGSGVGLA NGRISFSFGM TTKGKSNVPV

SSAQWFAFXT NLNAQSVKPI FNYGNPKEPE KATIEFNXYK ANVVPVLVPN KEVTDGQKNX

NDLNVXRGDS LQYIVTGDTT ELAKVDPKTV TKQGTRDTFD AEKVTIDLSK VKVYQADASL

NXKDXKAVAA AINSGXAKDV TASYXLNLDQ NTVTAMMKTN ADGSVVLANG YKYLLVLPFV

VKNVEGDFEN TAVQLTXDGE TVTNTVINHV PGSNPSKDVK ADKNGTVGSV SLHDKDIPLQ

TKIYYEVKSS ERPANYGGXT EEWGMNDVLD TTHDRETGKW HAITXYDLKV GXKTLKAGTD

ISAYILLENK DNKDLTFTMN QALLAALNEG SNKVGKQAWS VYLEVERXKT CDVENTQTEN

YNKELVRSNT VVTHTPDDPK PTKAVHNKKG EXIXHGKVAR GDVLSYEMTW DLKGYDKDFA

FDTVDLATGV SEFDDYDETX VTPIKDLLRV KDSKGXDITN QFTISWDDAK GTVTXSAKDP

QAFILAXGGQ ELRVTLPTKV KADVSGDVYN SAEQNTFGQR IKTNTVVNHI PKVXPKKDVV

IKVGDKQSQN GATTKLGEXF FYEFTSSDIP AEYAGVVEEW SISDKLDVKH DKFSGQWSVF

ANSNFVLADG TKVNKGDDIS KLFTMTFEQG VVKITASQAF XDAMNLKENK NVAHSWKAFT

GVERIAAGDV YNTTEESFNN EKIKTNTVVT HTPEKPQTPP EKTVIVPPTP KTPQAPVEPL

VVEKASV

SF063-1 (SEQ ID NO:237)

TGATTCTTGA AGCAACAAAT GAAAGCAAAA AAACAATATA AGACATATAA AGCTAAGAAT

CACTGGGTAA CTGTCCCTAT TCTTTTTCTA AGTGTGTTAG GAGCCGTACG ATTAGCTACT

GATAATGTAC AAGCCGCGGA ATTAGATACO CAACCAGAAA CAACGACGGT TCAACCCAAT

AACCCCGACC TGCAGTCAGA AAAGGAAACA CCTAAAACGG CAGTATCTGA AGAAGCAACA

GTACAAAAAG ACACTACTTC TCAACCGACC AAAGTAGAAG AAGTAGCGCC AGAAAATAAA

GGTACTGAAC AAAGTTCAGC TACCCCAAAT GATACCACAA ACGCGCAACA ACCAACAGTA

GGAGCTGAAA AATCAGCACA AGAACAACCA GTAGTAAGCC CTGAAACAAC CAATGAACCT

CTAGGGCAGC CAACAGAAGT TGCACCAGCT GAAAATGAAG TGAATAAATC AACGTCCATT

CCTAAAGAAT TTGAAACACC AGACGTTGAT AAAGCAGTTG ATGAAGTAAA AAAAGATCCA

AACATTACCG TTGTTGAAAA ACCAGCAGAA GACTTAGGCA ACGTTTCTTC TAAAGATTTA

GCTGCAAAAG AAAAAGAAGT AGACCAACTA CAAAAAGAAC AAGCGAAAAA GATTGCCCAA

CAAGCAGCTG AATTAAAAGC CAAAAATGAA AAAATTGCCA AAGAAAATGC AGAAATTGCG

GCAAAAAACA AAGCNGAAAA AGAGCGNTAN GANAAAGAAG TCGCNGAATA CAACAAGCAT

AAGAACGAAA ACAGCTATGT CAATGAAGCG ATTAGTAAAA ACCTAGTGTT CGATCAATCT

GTCGTGACGA AAGACACTAA AATTTCGTCG ATTAAAGGCG GAAAATTTAT CAAAGCAACT

GATTTTAATA AAGTAAATGC AGGGGATTCA AAAGATATCT TTACAAAATT ACGGAAAGAT

ATGGGNGGGA AAGNTACTGG CAACTTCCAG AATTCCTTTG TAAAAGAGGC AAATCTTGGG

TCTAATGGTG GGTATGCGGT TCTTTTAGAA AAAAATAAAC CAGTGACAGT GACCTATACA

GGACTAAACG CTAGTTATTT AGGACGTAAA ATTACAAAAG CAGAATTTGT TTATGAACTA

CAATCCTCAC CAAGCCAAAG TGGAACGTTA AATGCAGTAT TTTCAAACGA TCCGATTATC

ACNGCTTTTA TTGGTACAAA CAGAGTCAAT GGTAAGGATG TTAAAACACG CTTAACGATT

AAGTTCTTTG ATGCGTCAGG TAAAGAAGTA CTACCAGATA AAGATAGTCC ATTTGCGTAT

GCGCTGTCTT CTTTAAATTC AAGTTTAACG AATAAAGGTG GCCATGCGGA ATTTGTTTCT

GATTTTGGGG CNAACAATGC GTTCAAATAC ATTAATGGNT CNTATGTGAA AAAACAAGCG

GATGGAAAAT TTTACTCACC GGAAGATATT GACTATGGCA CAGGACCTTC TGGATTGAAA

AATAGTGATT GGGACGCTGT ACGTCACAAG AATGCCTACT TTCGTTCAGG TGTAGGTCTA

GCNAATGGNC GTATTTCCTT TTCTTTTGGT ATGACAACAA AAGGAAAAAG TAATGTGCCT

GTATCTAGTG CGCAATCGTT TCCCTTTAGN ACTAACTTAA ATGCGCAATC AGTGAAGCCT

ATTTTCAATT ATGGGAATCC AAAAGAACCA GAAAAAGCAA CGATTGAATT CAATNGATAC

AAAGCCAATG TCGTTCCTGT NCTTGTGCCN AATAAAGAAG TCACTGATGG NCAGAAAAAT

NTCAATGATT TAAATGTCAA NCGTGGCGAT TCTTTACAAT ACATTGTGAC AGGGGATACG

ACAGAACTTG CCAAAGTAGA TCCAAAAACA GTAACNAAAC AAGGGATTCG AGATACNTTT

GATGCAGAAA AAGTGACCAT TGATTTATCC AAAGTGAAAG TTTATCAAGC AGACGCAAGT

CTNAACGANA AAGACTNAAA AGCTGTTGCT GCAGCNATTA ATTCAGGAAN AGCTAAAGAC

GTGACTGCTT CTTATGANCT CAATTTAGAT CAAAACACCG TCACAGCAAT GATGAAAACC

AACGCNCACG GNTCNGTTGT TTTAGCAATG GGGTATAAAT ATTTACTTGT CTTGCCGTTT

GTAGTGAAAA ATGTAGAAGG CCATTTTGAA AATACAGCTG TTCAGCTGAC AAANGATGGN

GAAACGGTAA CAAATACAGT GATTAACCAT GTGCCAGGTA GTAATCCTTC CAAAGATGTA

AAAGCAGATA AAAACGGTAC AGTTGGCAGT GTTTCTCTAC ATGATAAAGA TATTCCGTTA

CAAACAAAAA TTTATTATGA AGTGAAATCT TCCGAACGTC CAGCNAACTA TGGCGGAATN

ACNGAAGAAT GGGGCATGAA TGATGTCTTG GACACGACCC ATGATCGTTT CACAGGNAAA

TGGCACGCTA TTACNAANTA TGACCTTAAA GTAGGGGANA AAACGTTAAA AGCAGGAACA

GATATTTCTG CCTACATTCT TTTAGAAAAC AAAGACAATA AAGACTTGAC GTTTACNATG

AATCAAGCAT TATTGGCNGC NTTAAATGAA GGAAGCAATA AAGTAGGCAA ACAAGCTTGG

TCTGTGTATC TGGAAGTCGA ACGGATNAAA ACAGGTGACG TAGAAAACAC GCAAACAGAA

AACTACAACA AAGAGCTTGT NCGTTCTAAT ACNGTGGTGA CGCATACNCC TGATGATCCA

AAACCAACCA AAGCCGTTCA TAACAAGAAA GGGGAAGANA TTAANCATGG AAAAGTNGCT

CGTGCTGATG TTCTTTCTTA TGAAATGACN TGGGACTTAA AAGGGTACGA TAAAGACTTT

GCCTTTGATA CAGTCGATCT TGCGACAGGC GTTTCTTTCT TCGATGATTA CGATGAAACG

AANGTGACAC CAATCAAAGA CTTACTTCGT GTCAAAGATT CTAAAGGGGN AGACATTACG

AACCAGTTCA CGATCTCNTG GGACGATGCC AAAGGCACGG TGACNATNTC TGCCAAAGAC

CCACAAGCCT TTATTCTAGC GNATGGTGGG CAAGAATTGC GTGTAACNCT CCCTACAAAA

GTCAAAGCCG ATGTTTCTGG NGATGTTTAT AATTCAGCGG AACAAAATAC ATTTGGNCAA

CCAATTAAAA CCAATACNGT TGTCAACCAT ATTCCAAAAG TGAANCCTAA AAAAGACGTG

GTTATTAAAG TNGGTGACAA ACAAAGTCAA AATGGNGCCA CAATCAAATT ACGGGACAAN

TTCTTCTATG AATTTACAAG TAGTGACATT CCTGCACAAT ACGCTGGNGT TGTGGAAGAA

TGGTCGATTA GCGATAAACT AGACGTCAAA CATGACAAAT TTAGTGGCCA ATGGTCTGTG

TTTGCCAATT CTAATTTTGT TTTAGCAGAC GGAACCAAAG TGAATAAAGG GGACGACATT

TCGAAACTAT TCACGATCAC CTTTGAACAA GGGGTAGTGA AAATCACGGC CAGTCAAGCC

TTTTTNGATG CGATGAATCT AAAAGAAAAC AAAAACGTTG CACACTCATG GAAAGCGTTC

ATTGGTGTAG AACGAATTGC GGCAGGAGAC GTTTACAACA CAATCGAAGA ATCTTTCAAC

AATGAGAAGA TTAAAACNAA TACGGTAGTG ACNCATACGC CAGAAAAACC ACAAACNCCA

CCAGAAAAAA CAGTGATTGT ACCACCAACA CCAAAAACAC CGCAAGCACC AGTAGAGCCA

TTAGTGGTAG AAAAGGCAAG TGTNGTGCCA GAATTGCCGC AAACAGGCGA AAAACAAAAT

GTCTTATTAA CGGTAGCTGG TAGTTTAGCC GCAATGCTTG GCTTAGCAGG CTTAGGCTTT

AAACGTAGAA AAGAAACAAA ATAA

EF063-2 (SEQ ID NO:238)

MKAKK QYKTYKAKNH WVTVPILFLS VLGAVGLATD NVQAAELDTQ PETTTVQPNN

PDLQSEKETP KTAVSEEATV QKDTTSQPTK VEEVAPENKG TEQSSATPND TTNAQQPTVG

AEKSAQEQPV VSPETTNEPL GQPTEVAPAE NEVNKSTSIP KEFETPDVDK AVDEVKKDPN

ITVVEKPAED LGNVSSKDLA AKEKEVDQLQ KEQAKKIAQQ AAELKAKNEK IAKENAEIAA

KNKAEKERXX KEVAEYNKHK NENSYVNEAT SKNLVFDQSV VTKDTKISSI KGGKFTKATD

FNKVNAGDSK DIFTKLRKDM GGKXTGNFQN SFVKEANLGS NGGYAVLLEK NKPVTVTYTG

LNASYLGRKI TKAEFVYELQ SSPSQSGTLN AVFSNDPTIT AFIGTNRVNG KDVKTRLTIK

FFDASGKEVL PDKDSPFAYA LSSLNSSLTN KGGHAEFVSD FGANNAFKYI NGSYVKKQAD

OKEYSPEDID YGTGPSGLKN SDWDAVGHKN AYFGSGVGLA NGRISFSFGM TTKGKSNVPV

SSAQWFAFXT NLNAQSVKPI FNYGNPKEPE KATIEFNXYK ANVVPVLVPN KEVTDGQKNX

NDLNVXRGDS LQYIVTGDTT ELAKVDPKTV TKQGIRDTFD AEKVTIDLSK VKVYQADASL

NXKDXKAVAA AINSGXAKDV TASYXLNLDQ NTVTANMKTN ADGSVVLAMG YKYLLVLPFV

VKNVEGDFEN TAVQLTXDGE TVTNTVINHV PGSNPSKDVK ADKNGTVGSV SLHDKDIPLQ

TKIYYEVKSS ERPANYGGXT EEWGMNDVLD TTHDRFTGKW HAITXYDLKV GXKTLKAGTD

ISAYILLENK DNKDLTFTMN QALLAALNEG SNKVGKQAWS VYLEVERXKT GDVENTQTEN

YNKELVRSNT VVTHTPDDPK PTKAVHNKKG EXTXHGKVAR GDVLSYEMTW DLKGYDKDFA

FDTVDLATGV SFFDDYDETX VTPIKDLLRV KDSKGXDITN QFTISWDDAK GTVTXSAKDP

QAFILAXGGQ ELRVTLPTKV KADVSGDVYN SAEQNTFGQR IKTNTVVNHI PKVXPKKDVV

IKVGDKQSQN GATIKLGEXF FYEFTSSDIP AEYAGVVEEW SISDKLDVKH DKFSGQWSVF

ANSNFVLADG TKVNKGDDIS KLFTMTFEQC VVKITASQAF XDAMNLKENK NVAHSWKAFT

GVERIAAGDV YNTIEESFNN EKIKTNTVVT HTPEKPQTPP EKTVIVPPTP KTPQAPVEPL

VVEKASVVPE LPQTGEKQNV LLTVAGSLAA MLGLAGLGFK RRKETK

EF063-3 (SEQ ID NO:239)

GGA ATTACATACG CAACCAGAAA CAACGACGGT TCAACCCAAT

AACCCCGACC TGCAGTCAGA AAAGGAAACA CCTAAAACGG CAGTATCTGA AGAAGCAACA

GTACAAAAAG ACACTACTTC TCAACCGACC AAAGTAGAAC AAGTAGCGCC AGAAAATAAA

GGTACTGAAC AAAGTTCAGC TACCCCAAAT GATACCACAA ACGCGCAACA ACCAACAGTA

GGAGCTGAAA AATCAGCACA AGAACAACCA GTAGTAAGCC CTGAAACAAC CAATGAACCT

CTAGGGCAGC CAACAGAAGT TGCACCAGCT GAAAATGAAG TGAATAAATC AACGTCCATT

CCTAAAGAAT TTGAAACACC AGACGTTGAT AAAGCAGTTG ATGAACTAAA AAAAGATCCA

AACATTACCG TTGTTGAAAA ACCAGCAGAA GACTTAGGCA ACGTTTCTTC TAAAGATTTA

GCTGCAAAAG AAAAAGAAGT AGACCAACTA CAAAAAGAAC AAGCGAAAAA GATTGCCCAA

CAAGCAGCTG AATTAAAAGC CAAAAATGAA AAAATTGCCA AAGAAAATCC AGAAATTGCG

GCAAAAAACA AAGCNGAAAA AGAGCGNTAN GANAAAGAAG TCGCNGAATA CAACAAGCAT

AAGAACGAAA ACAGCTATGT CAATGAAGCG ATTAGTAAAA ACCTAGTGTT CGATCAATCT

GTCGTGACGA AAGACACTAA AATTTCGTCG ATTAAAGGCG GAAAATTTAT CAAAGCAACT

GATTTTAATA AAGTAAATGC AGGGGATTCA AAAGATATCT TTACAAAATT ACGGAAAGAT

ATGGGNGGGA AAGNTACTGG CAACTTCCAG AATTCCTTTG TAAAAGAGGC AAATCTTGGG

TCTAATGGTG GGTATGCGGT TCTTTTAGAA AAAAATAAAC CAGTGACAGT GACCTATACA

GGACTAAACG CTAGTTATTT AGGACGTAAA ATTACAAAAG CAGAATTTGT TTATGAACTA

CAATCCTCAC CAAGCCAAAG TGGAACGTTA AATGCAGTAT TTTCAAACGA TCCGATTATC

ACNGCTTTTA TTGGTACAAA CAGAGTCAAT GGTAAGGATG TTAAAACACG CTTAACGATT

AAGTTCTTTG ATGCGTCAGG TAAAGAAGTA CTACCAGATA AAGATAGTCC ATTTGCGTAT

GCGCTGTCTT CTTTAAATTC AAGTTTAACG AATAAAGCTG GCCATGCGGA ATTTGTTTCT

GATTTTGGGG CNAACAATGC GTTCAAATAC ATTAATGGNT CNTATGTGAA AAAACAAGCG

GATGCAAAAT TTTACTCACC GGAAGATATT GACTATGGCA CAGGACCTTC TGGATTGAAA

AATAGTGATT GGGACGCTGT AGGTCACAAG AATGCCTACT TTGGTTCAGG TGTAGGTCTA

GCNAATGGNC GTATTTCCTT TTCTTTTGGT ATGACAACAA AAGGAAAAAG TAATGTGCCT

GTATCTAGTG CGCAATGGTT TGCCTTTAGN ACTAACTTAA ATGCGCAATC AGTGAAGCCT

ATTTTCAATT ATGGGAATCC AAAAGAACCA GAAAAAGCAA CGATTGAATT CAATNCATAC

AAAGCCAATG TCGTTCCTGT NCTTGTGCCN AATAAAGAAG TCACTGATGG NCAGAAAAAT

NTCAATGATT TAAATGTGAA NCGTGGCGAT TCTTTACAAT ACATTGTGAC AGGGGATACG

ACAGAACTTG CCAAAGTAGA TCCAAAAACA GTAACNAAAC AAGGGATTCG AGATACNTTT

GATGCAGAAA AAGTGACGAT TGATTTATCC AAAGTG

EF063-4 (SEQ ID NO:240)

ELDTQ PETTTVQPNN

PDLQSEKETP KTAVSEEATV QKDTTSQPTK VEEVAPENKG TEQSSATPND TTNAQQPTVG

AEKSAQEQPV VSPETTNEPL GQPTEVAPAE NEVNKSTSIP KEFETPDVDK AVDEVKKDPN

ITVVEKPAED LGNVSSKDLA AKEKEVDQLQ KEQAKKIAQQ AAELKAKNEK IAKENAEIAA

KNKAEKERXX KEVAEYNKHK NENSYVNEAT SKNLVFDQSV VTKDTKISSI KGGKFIKATD

FNKVNAGDSK DIFTKLRKDM GGKXTGNFQN SFVKEANLGS NGCYAVLLEK NKPVTVTYTG

LNASYLGRKI TKAEFVYELQ SSPSQSGTLN AVFSNDPIIT AFIGTNRVNG KDVKTRLTIK

FFDASGKEVL PDKDSPFAYA LSSLNSSLTN KGGHAEFVSD FGANNAFKYI NGSYVKKQAD

GKFYSPEDID YGTGPSGLKN SDWDAVGHKN AYFGSGVGLA NGRISFSFGM TTKGKSNVPV

SSAQWFAFXT NLNAQSVKPI FNYGNPKEPE KATIEFNXYK ANVVPVLVPN KEVTDGQKNX

NDLNVXRGDS LQYIVTGDTT ELAKVDPKTV TKQGIRDTFD AEKVTIDLSK V

EF064-1 (SEQ ID NO:241)

TCATTCTTGA ACCAACAAAT GAAAGCAAAA AAACAATATA AGACATATAA AGCTAAGAAT

CACTGGGTAA CTGTCCCTAT TCTTTTTCTA AGTGTGTTAG GAGCCGTAGG ATTAGCTACT

GATAATCTAC AAGCCGCGGA ATTAGATACG CAACCAGAAA CAACGACGGT TCAACCCAAT

AACCCCGACC TGCAGTCAGA AAAGGAAACA CCTAAAACGG CAGTATCTGA AGAAGCAACA

GTACAAAAAG ACACTACTTC TCAACCGACC AAAGTAGAAG AAGTAGCGCC AGAAAATAAA

GGTACTGAAC AAAGTTCAGC TACCCCAAAT GATACCACAA ACGCGCAACA ACCAACAGTA

GGAGCTGAAA AATCAGCACA AGAACAACCA GTAGTAACCC CTGAAACAAC CAATGAACCT

CTAGGGCAGC CAACAGAAGT TGCACCAGCT GAAAATGAAG TGAATAAATC AACGTCCATT

CCTAAAGAAT TTGAAACACC AGACGTTGAT AAAGCAGTTG ATGAAGTAAA AAAAGATCCA

AACATTACCG TTCTTGAAAA ACCAGCAGAA GACTTAGGCA ACGTTTCTTC TAAAGATTTA

GCTGCAAAAG AAAAAGAAGT AGACCAACTA CAAAAAGAAC AAGCGAAAAA GATTGCCCAA

CAAGCAGCTG AATTAAAAGC CAAAAATGAA AAAATTGCCA AAGAAAATGC AGAAATTGCG

GCAAAAAACA AAGCNGAAAA AGAGCGNTAN GANAAAGAAG TCGCNGAATA CAACAAGCAT

AAGAACGAAA ACACCTATGT CAATGAAGCG ATTAGTAAAA ACCTAGTGTT CGATCAATCT

GTCGTGACGA AAGACACTAA AATTTCGTCG ATTAAAGGCG GAAAATTTAT CAAAGCAACT

GATTTTAATA AAGTAAATGC AGGGGATTCA AAAGATATCT TTACAAAATT ACGGAAAGAT

ATGGGNGGGA AAGNTACTGG CAACTTCCAG AATTCCTTTG TAAAAGACGC AAATCTTGCG

TCTAATGGTG GGTATGCGGT TCTTTTAGAA AAAAATAAAC CAGTGACAGT GACCTATACA

GGACTAAACG CTAGTTATTT AGGACGTAAA ATTACAAAAG CAGAATTTGT TTATGAACTA

CAATCCTCAC CAAGCCAAAG TGGAACGTTA AATGCAGTAT TTTCAAACGA TCCGATTATC

ACNGCTTTTA TTGGTACAAA CAGAGTCAAT GGTAAGGATG TTAAAACACG CTTAACGATT

AAGTTCTTTG ATGCGTCAGG TAAAGAAGTA OTACCAGATA AAGATAGTCC ATTTGCGTAT

GCGCTGTCTT CTTTAAATTC AAGTTTAACG AATAAAGGTG GCCATGCGGA ATTTGTTTCT

GATTTTGGGG CNAACAATGC GTTCAAATAC ATTAATGGNT CNTATGTGAA AAAACAAGCG

GATGGAAAAT TTTACTCACC GGAAGATATT GACTATGGCA CAGGACCTTC TGGATTGAAA

AATAGTGATT GGGACGCTGT AGGTCACAAG AATGCCTACT TTGGTTCAGG TGTAGGTCTA

GCNAATGGNC GTATTTCCTT TTCTTTTGGT ATGACAACAA AAGGAAAAAG TAATGTGCCT

GTATCTAGTG CGCAATGGTT TGCCTTTAGN ACTAACTTAA ATGCGCAATC AGTGAAGCCT

ATTTTCAATT ATCGGAATCC AAAAGAACCA GAAAAAGCAA CGATTGAATT CAATNGATAC

AAAGCCAATG TCGTTCCTGT NCTTGTGCCN AATAAAGAAG TCACTGATGG NCAGAAAAAT

NTCAATGATT TAAATGTGAA NCGTGGCGAT TCTTTACAAT ACATTGTGAC AGGGGATACG

ACAGAACTTG CCAAAGTAGA TCCAAAAACA GTAACNAAAC AAGGGATTCG AGATACNTTT

GATGCAGAAA AAGTGACGAT TGATTTATCC AAAGTGAAAG TTTATCAAGC AGACGCAAGT

CTNAACGANA AAGACTNAAA AGCTGTTGCT GCAGCNATTA ATTCAGGAAN AGCTAAAGAC

GTGACTGCTT CTTATGANCT CAATTTAGAT CAAAACACCG TCACAGCAAT GATGAAAACC

AACGCNGACG GNTCNGTTGT TTTAGCAATG GGGTATAAAT ATTTACTTGT CTTGCCGTTT

GTAGTGAAAA ATGTAGAAGG CGATTTTGAA AATACAGCTG TTCAGCTGAC AAANGATGGN

CAAACGGTAA CAAATACAGT GATTAACCAT GTGCCAGGTA GTAATCCTTC CAAAGATGTA

AAAGCAGATA AAAACGGTAC AGTTGGCAGT GTTTCTCTAC ATGATAAAGA TATTCCGTTA

CAAACAAAAA TTTATTATGA AGTGAAATCT TCCGAACGTC CAGCNAACTA TGGCGGAATN

ACNGAAGAAT GGGGCATGAA TGATGTCTTG CACACGACCC ATGATCGTTT CACAGGNAAA

TGCCACGCTA TTACNAANTA TGACCTTAAA GTAGGGGANA AAACGTTAAA AGCAGGAACA

GATATTTCTG CCTACATTCT TTTAGAAAAC AAAGACAATA AAGACTTGAC GTTTACNATC

AATCAAGCAT TATTGGCNGC NTTAAATGAA GGAAGCAATA AAGTAGGCAA ACAAGCTTGG

TCTGTGTATC TGGAACTCGA ACGGATNAAA ACAGGTGACG TAGAAAACAC GCAAACAGAA

AACTACAACA AAGAGCTTGT NCGTTCTAAT ACNGTGGTGA CGCATACNCC TGATGATCCA

AAACCAACCA AAGCCGTTCA TAACAAGAAA GGGGAAGANA TTAANCATGG AAAAGTNGCT

CGTGGTGATG TTCTTTCTTA TGAAATGACN TGGGACTTAA AAGGGTACGA TAAAGACTTT

GCCTTTGATA CAGTCGATCT TGCGACAGGC GTTTCTTTCT TCGATGATTA CGATGAAACG

AANGTGACAC CAATCAAAGA CTTACTTCGT GTCAAAGATT CTAAAGGGCN AGACATTACG

AACCAGTTCA CGATCTCNTG GGACGATGCC AAAGGCACGG TGACNATNTC TGCCAAAGAC

CCACAAGCCT TTATTCTAGC GNATGGTGGG CAAGAATTGC GTCTAACNCT CCCTACAAAA

GTCAAAGCCG ATGTTTCTGG NGATGTTTAT AATTCAGCGG AACAAAATAC ATTTGGNCAA

CGAATTAAAA CCAATACNGT TGTCAACCAT ATTCCAAAAG TGAANCCTAA AAAAGACGTG

GTTATTAAAG TNGGTGACAA ACAAAGTCAA AATGGNGCCA CAATCAAATT AGGGGAGAAN

TTCTTCTATG AATTTACAAG TAGTGACATT CCTGCAGAAT ACGCTGGNGT TGTGGAAGAA

TGGTCGATTA GCGATAAACT AGACGTCAAA CATGACAAAT TTAGTGGCCA ATGGTCTGTG

TTTGCCAATT CTAATTTTGT TTTAGCAGAC GGAACCAAAG TGAATAAAGG GGACGACATT

TCGAAACTAT TCACGATGAC CTTTGAACAA GGGGTAGTGA AAATCACGGC CAGTCAAGCC

TTTTTNGATG CGATGAATCT AAAAGAAAAC AAAAACGTTG CACACTCATG GAAAGCGTTC

ATTGGTGTAG AACCAATTGC GOCAGGAGAC GTTTACAACA CAATCGAAGA ATCTTTCAAC

AATGAGAAGA TTAAAACNAA TACGGTAGTG ACNCATACGC CAGAAAAACC ACAAACNCCA

CCAGAAAAAA CAGTGATTGT ACCACCAACA CCAAAAACAC CGCAAGCACC AGTAGAGCCA

TTAGTGGTAG AAAAGGCAAG TGTNGTGCCA GAATTGCCGC AAACAGGCGA AAAACAAAAT

GTCTTATTAA CGGTAGCTGG TAGTTTAGCC GCAATGCTTG GCTTAGCAGG CTTAGGCTTT

AAACGTAGAA AAGAAACAAA ATAA

EF064-2 (SEQ ID NO:242)

MKAKK QYKTYKAKNH WVTVPILFLS VLGAVGLATD NVQAAELDTQ PETTTVQPNN

PDLQSEKETP KTAVSEEATV QKDTTSQPTK VEEVAPENKG TEQSSATPND TTNAQQPTVG

AEKSAQEQPV VSPETTNEPL GQPTEVAPAE NEVNKSTSIP KEFETPDVDK AVDEVKKDPN

ITVVEKPAED LGNVSSKDLA AKEKEVDQLQ KEQAKKIAQQ AAELKAKNEK IAKENAEIAA

KNKAEKERXX KEVAEYNKHK NENSYVNEAI SKNLVFDQSV VTKDTKISSI KGGKFIKATD

FNKVNAGDSK DIFTKLRKDM GGKXTGNFQN SFVKEANLGS NGGYAVLLEK NKPVTVTYTG

LNASYLGRKI TKAEFVYELQ SSPSQSGTLN AVFSNDPITT AFIGTNRVNG KDVKTRLTIK

FFDASGKEVL PDKDSPFAYA LSSLNSSLTN KGGHAEFVSD FGANNAFKYI NGSYVKKQAD

GKFYSPEDID YGTGPSGLKN SDWDAVGHKN AYFGSGVGLA NGRISFSFGM TTKGKSNVPV

SSAQWFAFXT NLNAQSVKPI FNYGNPKEPE KATIEFNXYK ANVVPVLVPN KEVTDGQKNX

NDLNVXRGDS LQYIVTGDTT ELAKVDPKTV TKQGIRDTFD AEKVTIDLSK VKVYQADASL

NXKDXKAVAA AINSGXAKDV TASYXLNLDQ NTVTAMMKTN ADGSVVLAMG YKYLLVLPFV

VKNVEGDFEN TAVQLTXDGE TVTNTVINHV PGSNPSKDVK ADKNGTVGSV SLHDKDIPLQ

TKIYYEVKSS ERPANYGGXT EEWGHNDVLD TTHDRFTGKW HAITXYDLKV GXKTLKAGTD

ISAYILLENK DNKDLTFTMN QALLAALNEG SNKVGKQAWS VYLEVERXKT GDVENTQTEN

YNKELVRSNT VVTHTPDDPK PTKAVHNKKG EXIXHGKVAR GDVLSYEMTW DLKGYDKDFA

FDTVDLATGV SFFDDYDETX VTPIKDLLRV KDSKGXDITN QFTISWDDAK GTVTXSAKDP

QAFILAXGGQ ELRVTLPTKV KADVSGDVYN SAEQNTFGQR IKTNTVVNHI PKVXPKKDVV

IKVGDKQSQN GATIKLGEXF FYEFTSSDIP AEYAGVVEEW SISDKLDVKH DKFSGQWSVF

ANSNFVLADG TKVNKGDDIS KLFTMTFEQG VVKITASQAF XDANNLKENK NVAHSWKAFT

GVERIAAGDV YNTLEESFNN EKIKTNTVVT HTPEKPQTPP EKTVIVPPTP KTPQAPVEPL

VVEKASVVPE LPQTGEKQNV LLTVAGSLAA MLGLAGLGFK RRKETK

EF064-3 (SEQ ID NO:243)

AGTGACGAT TGATTTATCC AAAGTGAAAG TTTATCAAGC AGACGCAAGT

CTNAACGANA AAGACTNAAA AGCTGTTGCT CCAGCNATTA ATTCAGGAAN AGCTAAAGAC

GTGACTGCTT CTTATGANCT CAATTTAGAT CAAAACACCC TCACAGCAAT GATGAAAACC

AACGCNGACG GNTCNGTTGT TTTAGCAATG GGGTATAAAT ATTTACTTGT CTTGCCGTTT

GTAGTGAAAA ATGTAGAAGG CGATTTTGAA AATACAGCTG TTCAGCTGAC AAANGATGGN

GAAACGGTAA CAAATACAGT GATTAACCAT CTGCCAGGTA GTAATCCTTC CAAAGATGTA

AAAGCAGATA AAAACGGTAC AGTTGGCAGT GTTTCTCTAC ATGATAAAGA TATTCCGTTA

CAAACAAAAA TTTATTATGA AGTGAAATCT TCCGAACGTC CAGCNAACTA TGGCGGAATN

ACNGAAGAAT GGGGCATGAA TGATGTCTTG GACACGACCC ATGATCGTTT CACAGGNAAA

TGGCACGCTA TTACNAANTA TGACCTTAAA GTAGGGGANA AAACGTTAAA AGCAGGAACA

GATATTTCTG CCTACATTCT TTTAGAAAAC AAAGACAATA AAGACTTGAC GTTTACNATG

AATCAAGCAT TATTGGCNGC NTTAAATGAA GGAAGCAATA AAGTAGGCAA ACAAGCTTGG

TCTGTGTATC TGGAAGTCGA ACGGATNAAA ACAGGTGACG TACAAAACAC GCAAACAGAA

AACTACAACA AAGAGCTTGT NCGTTCTAAT ACNGTGGTGA CGCATACNCC TGATGATCCA

AAACCAACCA AAGCCGTTCA TAACAAGAAA GGGGAAGANA TTAANCATGG AAAAGTNGCT

CGTGGTGATG TTCTTTCTTA TGAAATGACN TCGGACTTAA AAGGGTACGA TAAAGACTTT

GCCTTTGATA CAGTCGATCT TGCGACAGGC GTTTCTTTCT TCGATGATTA CGATGAAACG

AANGTGACAC CAATCAAAGA CTTACTTCGT GTCAAAGATT CTAAAGGGGN AGACATTACG

AACCAGTTCA CGATCTCNTG GGACGATGCC AAAGGCACGG TGACNATNTC TGCCAAAGAC

CCACAAGCCT TTATTCTAGC GNATGGTGGG CAAGAATTGC GTGTAACNCT CCCTACAAAA

GTCAAAGCCG ATGTTTCTGG NGATGTTTAT AATTCAGCGG AACAAAATAC ATTTGGNCAA

CGAATTAAAA CCAATACNGT TGTCAACCAT ATTCCAAAAG TGAANCCTAA AAAAGACGTG

GTTATTAAAG TNGGTGACAA ACAAAGTCAA AATGGNGCCA CAATCAAATT AGGGGAGAAN

TTCTTCTATG AATTTACAAG TAGTGACATT CCTGCAGAAT ACGCTGGNGT TGTGGAAGAA

TGGTCGATTA GCGATAAACT AGACGTCAAA CATGACAAAT TTAGTGGCCA ATGGTCTGTG

TTTGCCAATT CTAATTTTGT TTTAGCAGAC CGAACCAAAG TGAATAAAGG GGACGACATT

TCGAAACTAT TCACGATGAC CTTTGAACAA GGGGTAGTGA AAATCACGGC CAGTCAAGCC

TTTTTNGATG CGATGAATCT AAAACAAAAC AAAAACGTTG CACACTCATG GAAAGCGTTC

ATTGGTGTAG AACGAATTGC GGCAGGAGAC GTTTACAACA CAATCGAAGA ATCTTTCAAC

AATGAGAAGA TTAAAACNAA TACCGTAGTG ACNCATACGC CAGAAAAACC ACAAACNCCA

CCAGAAAAAA CAGTGATTGT ACCACCAACA CCAAAAACAC CGCAAGCACC AGTAGAGCCA

TTAGTGGTAG AAAAGGCAAG TGTNGTGCCA GAATTGCCGC AAACAGGCGA AAAACAAAAT

GTCTTATTAA CGGTAGCTCG TAGTTTAGCC CCAATGCTTG GCTTAC-CAGG CTTAGGCTTT

AAACGTAGAA AAGAAACAAA ATAA

EF064-4 (SEQ ID NO:244)

VTIDLSK VKVYQADASL

NXKDXKAVAA AINSGXAKDV TASYXLNLDQ NTVTANMKTN ADGSVVLAMG YKYLLVLPFV

VKNVEGDFEN TAVQLTXDGE TVTNTVINHV PGSNPSKDVK ADKNGTVGSV SLHDKDIPLQ

TKIYYEVKSS ERPANYGGXT EEWGMNDVLD TTHDRFTGKW HATTXYDLKV GXKTLKAGTD

ISAYILLENK DNKDLTFTMN QALLAALNEG SNKVGKQAWS VYLEVERXKT GDVENTQTEN

YNKELVRSNT VVTHTPDDPK PTKAVHNKKG EXIXHGKVAR GDVLSYEMTW DLKGYDKDFA

FDTVDLATGV SFFDDYDETX VTPIKDLLRV KDSKGXDITN QFTISWDDAK GTVTXSAKDP

QAFILAXGGQ ELRVTLPTKV KADVSGDVYN SAEQNTFGQR IKTNTVVNHI PKVXPKKDVV

IKVGDKQSQN GATIKLGEXF FYEFTSSDIP AEYAGVVEEW SISDKLDVKH DKFSGQWSVF

ANSNFVLADG TKVNKGDDTS KLFTMTFEQG VVKITASQAF XDAMNLKENK NVAHSWKAFI

GVERIAAGDV YNTTEESFNN EKIKTNTVVT HTPEKPQTPP EKTVIVPPTP KTPQAPVEPL

VVEKASV

EF065-1 (SEQ ID NO:245)

TAGCGAAAGA AAATAGGGAG GATTAAAATG TTTAAGAAAG CAACGAAATT ATTATCGACA

ATGGTGATTG TCGCTGGAAC AGTTGTCGGA AATTTCAGTC CCACATTGGC TTTAGCTGAA

GAAGCGGTTA AAGCAGGAGA TACAGAAGGA ATGACCAATA CGGTGAAAGT GAAAGACGAC

AGTCTGGCTG ATTGTAAACG GATATTGGAA GGACAAGCTA CTTTCCCAGT TCAAGCGGGT

GAAACGGAAC CAGTCGATTT AGTAGTTGTT GAAGATGCTA GTGGTAGTTT TTCAGATAAT

TTTCCACATG TAAGACAAGC GATTGATGAA GTGGTTCAAG GCTTATCTGA TCAAGACCGC

GTGATGCTGG CTTCATATCG CGGCGGAAAA CAATTTATGT TTCCTGATGG AAAGACAAAA

ATTAATTCAG CTGATTATGA TATGAATGTG CGCGTCAATA CGCAATTGAC TTATGATAAA

AGCCAATTTG TCTCTGGTTT TGGAGACGTT CGGACCTATG GTGGTACGCC AACCGCCCCA

CGATTGAAAC TCGCTTTAGA TACGTACAAT CAAACACACG GAGATTTAAC GAATCGAAAA

ACGTATTTCC TATTAGTGAC AGATGGGGTC GCTAATACAC GTTTAGATGG TTACTTGCAT

AAGACCAATA CCAATGATTC AATCAATGAA TATCCAGATC CAAGACATCC TCTTCAAGTC

TCAGTGGAAT ATAGTAATCA CTACCAAGGT GCAGCAGCAG AAGTTTTAGC GTTAAACCAA

GAAATTACTA ACCAAGGCTA TGAAATGATT AATGCGTATT GGGAAAGTGT TGAATCTTTA

AGTTCAGTGA ATTCATACTT TCATAAATAT AAAACAGAAC TGGCTCCTTT TGTAAAACAA

GAGTTGCAAC AAGGGTCTAG CACACCAGAA GATTTTATTA CAAGCCAATC TATTGATGAT

TTTACAACCC AATTAAAACA AATTGTCAAA CATCGTCTGG CGCAATCGAC ACCAGCAACA

GCTTCATTAA CGATTGCCAA TCAATTTGAT ATTCAATCTG CGACCGCTAC GGACGATGCT

GGAAATGATG TGCCTGTTCA AATTAACGGA CAAACCATTT CAGCAACTAG TACAGAAGGT

TACGTAGGAA ACATCACGAT TCACTACGAA GTCAAAGAAA ATACAGCGAT TGATGCAGCA

ACCCTTGTAA GTAGTGGGAC AATGAATCAA GGAACAATTG CTAAGGAATT TCCAGAAGCG

ACGATTCCTA AAAATGACAA TGCGCATGCG TGTGACGTGA CGCCAGAAGA TCCAACGATT

ACAAAAGATA TCGAAAATCA AGAACACTTA GATTTAACCA ATCGTGAAGA TAGTTTCGAT

TGGCATGTCA AAACAGCCTT TGOCAACGAA ACCAGTACTT GGACCCAAGC CAGCATGGTG

GATGACATTA ATAAAGTGCT AGATATCATT GATGTGAAAG TCACCGACGA AAATGGTAAA

GATGTTACAG CTAACCGCAC AGTAACACAA GAAAATAACA AAGTAACTTT TGAAATGAAC

AAACAAGCAG ACAGCTATGA CTATTTAAGT GGTCATACGT ATACAATGAC TATOACCACT

AAAATTAAAA CTGACGCAAC GGACGAACAA TTAGCGCCTT ACATTGAACA AGGCGGGATT

CCCAACCAAG CCGACTTAAA CTTTGGCAAT GAAGGTGACG TGTTACATTC CAACAAACCA

ACCGTAACAC CACCGCCAGT TGATCCAAAT ATTGCTAAAG ACGTAGAAGG ACAAGAACAT

TTAGATTTAA CCAACCGCGA TCAAGAATTT AAATGCAACG TCAAAACAGC TTTCGGTAAC

GAAACAAGCA CTTGGACCCA AGCCAGCATG GTAGATGACA TTAATAAAGT GTTAGACATC

ACTGATGTAA AAGTCACAGA TGAAAATGGT AAAGATGTTA CAGCTAACGG CAAAGTAACA

CAAGAAAATA ACAAAGTAAC TTTTGAAATG AACAANCAAG CNGACAGCTA TGACTATTTA

AGTGGTCATA CGTACACAAT GACCATTACT ACTAAAATCA AAGCTAGCGC AACGCACGAA

GAATTAGCAC CTTATATTGA ACAAGGTGGC ATTCCCAACC AAGCCGACTT GAACTTTGGC

AACGAAGGTG ACGTGTTGCA TTCCAACAAA CCAACCGTAA CACCACCTCC ACCAACGCCA

GAAGATCCAA CGATTACAAA AGATATCGAA GGCCAAGAAC ATTTAGATTT AACCAACCGT

GACCAAGAAT TTAAATGGAA CGTCAAAACA GCTTTCCGTA ACGAAACAAG CACATGGACC

CAAGCCAGCA TGGTGGATGA CATTAATAAA GTGTTAGACA TCACAGACGT GAAAGTTNCT

GANGAAAATG GCAAAGATGT TACAGATAAT GGCATAGTAA CACAAGAAAA TAACAAAGTA

ACTTTTACTA TCAACAAAAA AGATGACAGC TACTCTTACT TAGCTGGTCA TACATACACA

ATGACTATTA CCACTAAAAT TAAAACTGAC GCAACGGATG AAGAATTAGC GCCTTATATT

GAACAAGGCG GGATTCCCAA CCAAGCCGAC TTAAACTTTG GCAACGAAGG TGACGTGTTG

CATTCCAACA AGCCAACCGT AACACCGCCT GCACCAACGC CAGAAGACCC AAAAAAACCT

GAACCTAAAC AACCGCTAAA ACCGAAAAAA CCGTTGACGC CTACAAATCA TCAAGCACCA

ACGAACCCAG TCAATTTTGG AAAATCAGCA AGTAAAGGAA TTCATTTACC AATGACTAAT

ACAACAGTAA ATCCACTTTA CATGATCGCA GGTTTAATTG TCCTTATAGT GGCTATTAGC

TTTGGCATAA CAAAAAATAA AAAAAGAAAA AATTAG

EF065-2 (SEQ ID NO:246)

ME KKATKLLSTM VIVAGTVVGN FSPTLALAEE AVKAGDTEGM TNTVKVKDDS

LADCKRILEG QATFPVQAGE TEPVDLVVVE DASGSFSDNF PHVRQAIDEV VQGLSDQDRV

MLASYRGGKQ FMFPDGKTKI NSADYDMNVR VNTQLTYDKS QFVSGFGDVR TYGGTPTAPG

LKLALDTYNQ THGDLTNRKT YFLLVTDGVA NTRLDGYLHK TNTNDSINEY PDPRHPLQVS

VEYSNDYQGA AAEVLALNQE ITNQGYEMIN AYWESVESLS SVNSYFDKYK TEVGPFVKQE

LQQGSSTPED FITSQSIDDF TTQLKQIVKD RLAQSTPATA SLTIANQFDI QSATATDDAG

NDVPVQINGQ TISATSTEGY VGNITTHYEV KENTAIDAAT LVSSGTMNQG TIAKEEPEAT

IPKNDNAHAC DVTPEDPTIT KDIENQEHLD LTNREDSFDW HVKTAFGNET STWTQASMVD

DINKVLDIID VKVTDENGKD VTANGTVTQE NNKVTFEMNK QADSYDYLSG HTYTMTITTK

TKTDATDEEL APYTEQGGIP NQADLNFGNE GDVLHSNKPT VTPPPVDPNI AKDVEGQEHL

DLTNRDQEFK WNVKTAFGNE TSTWTQASMV DDINKVLDIT DVKVTDENGK DVTANGKVTQ

ENNKVTFEHN XQADSYDYLS GHTYTMTITT KIKASATDEE LAPYIEQGGI PNQADLNFGN

EGDVLHSNKP TVTPPAPTPE DPTITKDIEG QEHLDLTNRD QEFKWNVKTA FGNETSTWTQ

ASMVDDINKV LDITDVKVXX ENGKDVTDNG IVTQENNKVT FTMNKKDDSY SYLAGHTYTM

TITTKIKTDA TDEELAPYIE QGGIPNQADL NFGNEGDVLH SNKPTVTPPA PTPEDPKKPE

PKQPLKPKKP LTPTNHQAPT NPVNFGKSAS KGTHLPMTNT TVNPLYMIAG LIVLIVAISF

GITKNKKRKN

EF065-3 (SEQ ID NO:247)

GGTTA AAGCAGGAGA TACAGAAGGA ATGACCAATA CGGTGAAAGT GAAAGACGAC

AGTCTGGCTG ATTGTAAACG GATATTGGAA GGACAAGCTA CTTTCCCAGT TCAAGCGGGT

GAAACGGAAC CAGTCGATTT AGTAGTTGTT GAAGATGCTA GTGGTAGTTT TTCAGATAAT

TTTCCACATG TAAGACAAGC GATTGATGAA GTGGTTCAAG GCTTATCTGA TCAAGACCGC

GTGATGCTGG CTTCATATCG CGGCGGAAAA CAATTTATGT TTCCTGATGG AAAGACAAAA

ATTAATTCAG CTGATTATGA TATGAATGTG CGCGTCAATA CGCAATTGAC TTATGATAAA

AGCCAATTTG TCTCTGGTTT TGGAGACGTT CGGACGTATG GTGGTACGCC AACCGCCCCA

GGATTGAAAC TCGCTTTAGA TACCTACAAT CAAACACACG GAGATTTAAC GAATCGAAAA

ACGTATTTCC TATTAGTGAC AGATGGGGTC GCTAATACAC GTTTAGATGG TTACTTGCAT

AAGACCAATA CCAATGATTC AATCAATGAA TATCCAGATC CAAGACATCC TCTTCAAGTC

TCAGTGGAAT ATAGTAATGA CTACCAAGGT GCAGCAGCAC AAGTTTTAGC GTTAAACCAA

GAAATTACTA ACCAAGGCTA TGAAATGATT AATGCGTATT GGGAAAGTGT TGAATCTTTA

AGTTCACTGA ATTCATACTT TGATAAATAT AAAACAGAAC TGGGTCCTTT TGTAAAACAA

GAGTTGCAAC AAGGCTCTAG CACACCAGAA GATTTTATTA CAAGCCAATC TATTGATGAT

TTTACAACCC AATTAAAACA AATTGTCAAA GATCGTCTGG CGCAATCGAC ACCAGCAACA

GCTTCATTAA CGATTGCCAA TCAATTTGAT ATTCAATCTG CGACCGCTAC GGACGATGCT

GGAAATGATG TGCCTGTTCA AATTAACGGA CAAACCATTT CAGCAACTAG TACAGAAGGT

TACGTAGGAA ACATCACGAT TCACTACGAA GTCAAAGAAA ATACAGCGAT TGATCCAGCA

ACCCTTGTAA GTAGTGGGAC AATGAATCAA GGAACAATTG CTAAGGAATT TCCAGAAGCG

ACGATTCCTA AAAATGACAA TGCGCATGCG TGTGACGTGA CGCCAGAAGA TCCAACGATT

ACAAAAGATA TCGAAAATCA AGAACACTTA GATTTAACCA ATCGTGAAGA TAGTTTCGAT

TGGCATGTCA AAACACCCTT TGCCAACGAA ACCAGTACTT GGACCCAAGC CAGCATGGTG

GATGACATTA ATAAAGTGCT ACATATCATT GATGTGAAAG TCACCGACGA AAATGGTAAA

GATGTTACAG CTAACGGCAC AGTAACACAA GAAAATAACA AAGTAACTTT TGAAATGAAC

AAACAAGCAG ACAGCTATGA CTATTTAAGT GGTCATACGT ATACAATGAC TATCACCACT

AAAATTAAAA CTGACGCAAC GGACGAAGAA TTAGCGCCTT ACATTGAACA AGGCGGGATT

CCCAACCAAG CCGACTTAAA CTTTGGCAAT GAAGGTGACG TGTTACATTC CAACAAACCA

ACCGTAACAC CACCGCCAGT TGATCCAAAT ATTGCTAAAG ACGTAGAAGG ACAAGAACAT

TTAGATTTAA CCAACCGCGA TCAAGAATTT AAATGGAACG TCAAAACAGC TTTCGGTAAC

GAAACAAGCA CTTGGACCCA AGCCAGCATG GTAGATGACA TTAATAAAGT GTTAGACATC

ACTGATCTAA AAGTCACAGA TGAAAATGGT AAAGATCTTA CAGCTAACGG CAAAGTAACA

CAAGAAAATA ACAAAGTAAC TTTTGAAATG AACAANCAAG CNGACAGCTA TGACTATTTA

AGTGGTCATA CGTACACAAT GACCATTACT ACTAAAATCA AAGCTAGCGC AACGGACGAA

GAATTAGCAC CTTATATTGA ACAAGGTGGC ATTCCCAACC AAGCCGACTT GAACTTTGGC

AACGAAGGTG ACGTGTTGCA TTCCAACAAA CCAACCGTAA CACCACCTGC ACCAACGCCA

GAAGATCCAA CGATTACAAA AGATATCGAA GGCCAAGAAC ATTTAGATTT AACCAACCGT

GACCAAGAAT TTAAATGGAA CGTCAAAACA GCTTTCGGTA ACGAAACAAG CACATGGACC

CAAGCCAGCA TGGTGCATGA CATTAATAAA GTGTTAGACA TCACAGACGT GAAAGTTNCT

GANGAAAATG GCAAAGATGT TACAGATAAT GGCATAGTAA CACAAGAAAA TAACAAAGTA

ACTTTTACTA TGAACAAAAA AGATGACAGC TACTCTTACT TAGCTGGTCA TACATACACA

ATGACTATTA CCACTAAAAT TAAAACTGAC GCAACGGATG AAGAATTAGC GCCTTATATT

GAACAAGGCG GGATTCCCAA CCAAGCCGAC TTAAACTTTG GCAACGAAGG TGACGTGTTG

CATTCCAACA AGCCAACCGT AACACCGCCT GCACCAACGC CAGAAGACCC AAAAAAACCT

GAACCTAAAC AACCGCTAAA ACCGAAAAAA CCGTTGACGC CTACAAATCA TCAAGCACCA

ACGAACCCAG TCAATTTTGG AAAATCAGCA AGTAAAGGAA TT

EF065-4 (SEQ ID NO:248)

AVKAGDTEGM TNTVKVKDDS

LADCKRILEG QATFPVQAGE TEPVDLVVVE DASGSFSDNF PHVRQAIDEV VQGLSDQDRV

MLASYRGGKQ FMFPDGKTKI NSADYDMNVR VNTQLTYDKS QFVSGFGDVR TYGGTPTAPG

LKLALDTYNQ THGDLTNRKT YFLLVTDGVA NTRLDGYLHK TNTNDSINEY PDPRHPLQVS

VEYSNDYQGA AAEVLALNQE ITNQGYEMTN AYWESVESLS SVNSYFDKYK TEVGPFVKQE

LQQGSSTPED FITSQSIDDF TTQLKQIVKD RLAQSTPATA SLTIANQFDT QSATATDDAG

NDVPVQINGQ TISATSTEGY VGNITIHYEV KENTAIDAAT LVSSGTMNQG TTAKEFPEAT

IPKNDNAHAC DVTPEDPTIT KDIENQEHLD LTNREDSFDW HVKTAFGNET STWTQASMVD

DINKVLDIID VKVTDENGKD VTANGTVTQE NNKVTFEMNK QADSYDYLSG HTYTMTITTK

IKTDATDEEL APYIEQGGIP NQADLNFGNE GDVLHSNKPT VTPPPVDPNI AKDVEGQEHL

DLTNRDQEFK WNVKTAFGNE TSTWTQASMV DDINKVLDIT DVKVTDENGK DVTANGKVTQ

ENNKVTFEMN XQADSYDYLS GHTYTMTITT KIKASATDEE LAPYIEQGGI PNQADLNFGN

EGDVLHSNKP TVTPPAPTPE DPTITKDIEG QEHLDLTNRD QEFKWNVKTA FGNETSTWTQ

ASMVDDINKV LDITDVKVXX ENGKDVTDNG IVTQENNKVT FTMNKKDDSY SYLAGHTYTM

TITTKIKTDA TDEELAPYIE QGGIPNQADL NFGNEGDVLH SNKPTVTPPA PTPEDPKKPE

PKQPLKPKKP LTPTNHQAPT NPVNFGKSAS KGIH

EF066-1 (SEQ ID NO:249)

TAGCGAAAGA AAATAGGGAG GATTAAAATG TTTAAGAAAG CAACGAAATT ATTATCGACA

ATGGTGATTG TCGCTGGAAC AGTTGTGGGA AATTTCAGTC CCACATTGGC TTTAGCTGAA

GAAGCGGTTA AAGCAGGAGA TACAGAAGGA ATGACCAATA CGGTGAAAGT GAAAGACGAC

AGTCTGGCTG ATTGTAAACG GATATTGGAA GGACAAGCTA CTTTCCCAGT TCAAGCGGGT

GAAACGCAAC CAGTCGATTT AGTAGTTGTT GAAGATGCTA GTGGTAGTTT TTCAGATAAT

TTTCCACATG TAAGACAAGC GATTGATGAA GTGGTTCAAG GCTTATCTCA TCAAGACCGC

GTGATGCTGG CTTCATATCG CGGCGGAAAA CAATTTATGT TTCCTGATGG AAAGACAAAA

ATTAATTCAG CTGATTATGA TATGAATGTG CGCGTCAATA CGCAATTCAC TTATGATAAA

AGCCAATTTG TCTCTGGTTT TGGAGACGTT CGGACGTATG GTGGTACGCC AACCGCCCCA

GGATTGAAAC TCGCTTTAGA TACGTACAAT CAAACACACG GAGATTTAAC GAATCGAAAA

ACGTATTTCC TATTAGTGAC AGATGGGGTC GCTAATACAC GTTTAGATGG TTACTTGCAT

AAGACCAATA CCAATGATTC AATCAATGAA TATCCAGATC CAAGACATCC TCTTCAAGTC

TCAGTGGAAT ATAGTAATGA CTACCAAGGT GCAGCAGCAG AAGTTTTAGC GTTAAACCAA

GAAATTACTA ACCAAGGCTA TGAAATGATT AATGCGTATT GGGAAAGTGT TGAATCTTTA

AGTTCAGTGA ATTCATACTT TGATAAATAT AAAACAGAAG TGGGTCCTTT TGTAAAACAA

CAGTTGCAAC AACGGTCTAG CACACCAGAA GATTTTATTA CAACCCAATC TATTGATGAT

TTTACAACCC AATTAAAACA AATTGTCAAA GATCGTCTGG CGCAATCGAC ACCAGCAACA

GCTTCATTAA CGATTGCCAA TCAATTTGAT ATTCAATCTG CCACCGCTAC CCACGATGCT

GGAAATGATG TGCCTGTTCA AATTAACGGA CAAACCATTT CAGCAACTAG TACAGAAGGT

TACGTAGGAA ACATCACGAT TCACTACGAA GTCAAAGAAA ATACAGOGAT TGATGCAGCA

ACCCTTGTAA GTAGTGGGAC AATGAATCAA GGAACAATTG CTAAGCAATT TCCAGAAGCG

ACGATTCCTA AAAATGACAA TGCGCATGCG TGTGACGTGA CGCCAGAAGA TCCAACGATT

ACAAAAGATA TCGAAAATCA ACAACACTTA GATTTAACCA ATCGTGAAGA TAGTTTCGAT

TGGCATGTCA AAACAGCCTT TGGCAACGAA ACCAGTACTT GCACCCAAGC CAGCATGGTG

GATGACATTA ATAAAGTGCT AGATATCATT GATGTGAAAG TCACCGACGA AAATGGTAAA

GATGTTACAG CTAACGGCAC AGTAACACAA GAAAATAACA AAGTAACTTT TGAAATGAAC

AAACAAGCAG ACAGCTATGA CTATTTAAGT GGTCATACGT ATACAATGAC TATCACCACT

AAAATTAAAA CTGACGCAAC GGACGAAGAA TTAGCGCCTT ACATTGAACA AGGCGGGATT

CCCAACCAAG CCGACTTAAA CTTTGGCAAT GAAGGTGACG TGTTACATTC CAACAAACCA

ACCGTAACAC CACCGCCAGT TGATCCAAAT ATTGCTAAAG ACGTAGAAGG ACAAGAACAT

TTAGATTTAA CCAACCGCGA TCAAGAATTT AAATGGAACG TCAAAACAGC TTTCCGTAAC

GAAACAAGCA CTTGGACCCA AGCCAGCATG GTAGATGACA TTAATAAAGT GTTAGACATC

ACTGATGTAA AAGTCACAGA TGAAAATGGT AAAGATGTTA CAGCTAACGG CAAAGTAACA

CAAGAAAATA ACAAAGTAAC TTTTGAAATG AACAANCAAG CNGACAGCTA TGACTATTTA

AGTGGTCATA CGTACACAAT GACCATTACT ACTAAAATCA AAGCTAGCGC AACGGACGAA

GAATTAGCAC CTTATATTGA ACAAGGTGGC ATTCCCAACC AAGCCCACTT GAACTTTGGC

AACGAAGGTG ACGTGTTGCA TTCCAACAAA CCAACCGTAA CACCACCTGC ACCAACGCCA

GAAGATCCAA CGATTACAAA AGATATCGAA GGCCAAGAAC ATTTAGATTT AACCAACCGT

GACCAAGAAT TTAAATGGAA CGTCAAAACA GCTTTCGGTA ACGAAACAAG CACATGGACC

CAAGCCAGCA TGGTGGATGA CATTAATAAA GTGTTAGACA TCACAGACGT GAAAGTTNCT

GANGAAAATC GCAAAGATCT TACAGATAAT GGCATAGTAA CACAAGAAAA TAACAAAGTA

ACTTTTACTA TGAACAAAAA AGATGACAGC TACTCTTACT TAGCTGGTCA TACATACACA

ATGACTATTA CCACTAAAAT TAAAACTGAC GCAACGGATG AAGAATTAGC GCCTTATATT

GAACAAGGCG GGATTCCCAA CCAAGCCGAC TTAAACTTTG GCAACGAAGG TGACGTGTTG

CATTCCAACA AGCCAACCCT AACACCGCCT GCACCAACGC CAGAAGACCC AAAAAAACCT

GAACCTAAAC AACCGCTAAA ACCCAAAAAA CCGTTGACGC CTACAAATCA TCAAGCACCA

ACGAACCCAG TCAATTTTGG AAAATCAGCA AGTAAAGGAA TTCATTTACC AATGACTAAT

ACAACAGTAA ATCCACTTTA CATGATCGCA GGTTTAATTG TCCTTATAGT GGCTATTAGC

TTTGGCATAA CAAAAAATAA AAAAAGAAAA AATTAG

EF066-2 (SEQ ID NO:250)

MF KKATKLLSTM VIVAGTVVGN FSPTLALAEE AVKAGDTEGM TNTVKVKDDS

LADCKRILEG QATFPVQAGE TEPXTDLVVVE DASGSFSDNF PHVRQAIDEV VQGLSDQDRV

MLASYRGGKQ FMFPDGKTKI NSADYDMNVR VKTQLTYDKS QFVSGFGDVR TYGGTPTAPC

LKLALDTYNQ THGDLTNRKT YFLLVTDGVA NTRLDGYLHK TNTNDSINEY PDPRHPLQVS

VEYSNDYQGA AAEVLALNQE ITNQGYEMTN AYWESVESLS SVNSYFDKYK TEVGPFVKQE

LQQGSSTPED FITSQSIDDF TTQLKQIVKD RLAQSTPATA SLTIANQFDI QSATATDDAG

NDVPVQTNGQ TISATSTEGY VGNITIHYEV KENTAIDAAT LVSSGTMNQG TIAKEFFEAT

IPKNDNAHAC DVTPEDPTIT KDIENQEHLD LTNREDSFDW HVKTAFGNET STWTQASMVD

DINKVLDIID VKVTDENGKD VTANGTVTQE NNKVTFEHNK QADSYDYLSG HTYTMTTTTK

IKTDATDEEL APYIEQGGIP NQADLNFGNE GDVLHSNKPT VTPPPVDPNI AKDVEGQEHL

DLTNRDQEFK WNVKTAFGNE TSTWTQASMV DDTNKVLDTT DVKVTDENGK DVTANGKVTQ

ENNKVTFEMN XQADSYDYLS GHTYTMTITT KIKASATDEE LAPYIEQGGI PNQADLNFGN

EGDVLHSNKP TVTPPAPTPE DPTITKDIEG QEHLDLTNRD QEFKWNVKTA FGNETSTWTQ

ASMVDDINKV LDITDVKVXX ENGKDVTDNG IVTQENNKVT FTMNKKDDSY SYLAGHTYTM

TITTKIKTDA TDEELAPYTE QGGTPNQADL NFGNEGDVLH SNKPTVTPPA PTPEDPKKPE

PKQPLKPKKP LTPTNHQAPT NPVNFGKSAS KGIHLPMTNT TVNPLYMIAG LIVLIVAISF

GITKNKKRKN

EF066-3 (SEQ ID NO:251)

GGTTA AAGCAGGAGA TACAGAACGA ATGACCAATA CGGTGAAAGT GAAAGACGAC

AGTCTGGCTG ATTGTAAACG GATATTGGAA GGACAAGCTA CTTTCCCAGT TCAAGCGGGT

GAAACGGAAC CAGTCGATTT AGTAGTTGTT GAAGATGCTA GTGGTAGTTT TTCAGATAAT

TTTCCACATC TAAGACAAGC GATTGATGAA GTGGTTCAAG GCTTATCTGA TCAAGACCGC

GTGATGCTGG CTTCATATCG CGGCGGAAAA CAATTTATGT TTCCTGATGG AAAGACAAAA

ATTAATTCAG CTGATTATGA TATGAATGTG CCCGTCAATA CGCAATTGAC TTATGATAAA

AGCCAATTTG TCTCTGGTTT TGGAGACGTT CGGACGTATG GTGGTACGCC AACCGCCCCA

GGATTGAAAC TCGCTTTAGA TACGTACAAT CAAACACACG GAGATTTAAC GAATCGAAAA

ACGTATTTCC TATTAGTGAC AGATGGGGTC GCTAATACAC GTTTAGATGG TTACTTGCAT

AAGACCAATA CCAATGATTC AATCAATGAA TATCCAGATC CAAGACATCC TCTTCAAGTC

TCAGTGGAAT ATAGTAATGA CTACCAAGGT GCAGCAGCAG AAGTTTTAGC GTTAAACCAA

GAAATTACTA ACCAAGGCTA TGAAATGATT AATGCGTATT GGCAAAGTGT TGAATCTTTA

AGTTCAGTGA ATTCATACTT TGATAAATAT AAAACAGAAG TGGGTCCTTT TGTAAAACAA

GAGTTGCAAC AAGGGTCTAG CACACCAGAA GATTTTATTA CAAGCCAATC TATTGATGAT

TTTACAACCC AATTAAAACA AATTGTCAAA GATCGTCTGG CGCAATCGAC ACCAGCAACA

GCTTCATTAA CGATTGCCAA TCAATTTGAT ATTCAATCTG CGACCGCTAC GGACGATGCT

GGAAATGATG TGCCTGTTCA AATTAACGGA CAAACCATTT CAGCAACTAG TACAGAAGGT

TACGTAGGAA ACATCACGAT TCACTACGAA GTCAAAGAAA ATACAGCGAT TGATGCAGCA

ACCCTTGTAA GTAGTGGGAC AATGAATCAA GGAACAATTG CTAAGGAATT TCCAGAAGCG

ACCATTCCTA AAAATGACAA TGCGCATGCC TGTGACGTGA CGCCAGAAGA TCCAACGATT

ACAAAAGATA TCGAAAATCA AGAACACTTA GATTTAACCA ATCGTGAAGA TAGTTTCGAT

TGGCATGTCA AAACAGCCTT TGGCAACGAA ACCAGTACTT GGACCCAAGC CAGCATGGTG

GATGACATTA ATAAAGTGCT AGATATCATT GATGTGAAAG TCA

EF066-4 (SEQ ID NO:252)

AVKAGDTEGM TNTVKVKDDS

LADCKRTLEG QATFPVQAGE TEPVDLVVVE DASGSFSDNF PHVRQAIDEV VQGLSDQDRV

MLASYRGGKQ FMFPDGKTKI NSADYDMNVR VNTQLTYDKS QFVSGFGDVR TYGGTPTAPG

LKLALDTYNQ THGDLTNRKT YFLLVTDGVA NTRLDGYLHK TNTNDSINEY PDPRHPLQVS

VEYSNDYQGA AAEVLALNQE ITNQGYEMIN AYWESVESLS SVNSYFDKYK TEVGPFVKQE

LQQGSSTPED FITSQSIDDF TTQLKQIVKD RLAQSTPATA SLTIANQFDI QSATATDDAG

NDVPVQINGQ TISATSTEGY VGNITIHYEV KENTAIDAAT LVSSGTMNQG TIAKEFPEAT

IPKNDNAHAC DVTPEDPTIT KDIENQEHLD LTNREDSFDW HVKTAFGNET STWTQASMVD

DINKVLDIID VKVT

EF067-1 (SEQ ID NO:253)

TAGCGAAAGA AAATAGGGAG GATTAAAATG TTTAAGAAAG CAACGAAATT ATTATOGACA

ATGGTGATTG TCGCTGGAAC AGTTGTGGGA AATTTCAGTC CCACATTGGC TTTAGCTGAA

GAAGCGGTTA AAGCAGGAGA TACAGAAGGA ATGACCAATA CGGTGAAAGT GAAAGACGAC

AGTCTGGCTG ATTGTAAACG GATATTGGAA GGACAAGCTA CTTTCCCAGT TCAAGCGGGT

GAAACGGAAC CAGTCGATTT AGTAGTTGTT GAAGATGCTA GTGGTAGTTT TTCAGATAAT

TTTCCACATG TAAGACAAGC GATTGATGAA GTGGTTCAAG GCTTATCTGA TCAAGACCGC

GTGATGCTGG CTTCATATCG CGGCGGAAAA CAATTTATGT TTCCTGATGG AAAGACAAAA

ATTAATTCAG CTGATTATGA TATGAATGTG CGCGTCAATA CGCAATTGAC TTATGATAAA

AGCCAATTTG TCTCTGGTTT TGGAGACGTT CGGACGTATG GTGGTACGCC AACCGCCCCA

GGATTGAAAC TCGCTTTAGA TACGTACAAT CAAACACACG GAGATTTAAC GAATCGAAAA

ACGTATTTCC TATTAGTCAC AGATGGGGTC GCTAATACAC GTTTAGATGG TTACTTGCAT

AAGACCAATA CCAATGATTC AATCAATGAA TATCCAGATC CAAGACATCC TCTTCAAGTC

TCAGTGGAAT ATAGTAATGA CTACCAAGGT CCAGCAGCAG AAGTTTTAGC GTTAAACCAA

GAAATTACTA ACCAAGGCTA TGAAATGATT AATGCGTATT GGGAAAGTGT TGAATCTTTA

AGTTCAGTGA ATTCATACTT TGATAAATAT AAAACAGAAG TGGGTCCTTT TGTAAAACAA

GAGTTGCAAC AAGGGTCTAG CACACCAGAA GATTTTATTA CAAGCCAATC TATTGATGAT

TTTACAACCC AATTAAAACA AATTGTCAAA GATCGTCTGG CCCAATCGAC ACCAGCAACA

GCTTCATTAA CGATTGCCAA TCAATTTGAT ATTCAATCTG CGACCGCTAC GGACGATGCT

GGAAATGATG TGCCTGTTCA AATTAACGGA CAAACCATTT CAGCAACTAG TACAGAAGGT

TACCTAGGAA ACATCACGAT TCACTACCAA GTCAAACAAA ATACAGCGAT TGATCCAGCA

ACCCTTGTAA GTAGTGGGAC AATGAATCAA GGAACAATTG CTAACGAATT TCCAGAAGCG

ACGATTCCTA AAAATGACAA TGCOCATGCG TGTGACGTGA CGCCAGAAGA TCCAACGATT

ACAAAAGATA TCGAAAATCA AGAACACTTA GATTTAACCA ATCGTGAAGA TAGTTTCGAT

TGGCATGTCA AAACAGCCTT TGGCAACCAA ACCAGTACTT GGACCCAAGC CAGCATGGTG

GATGACATTA ATAAAGTGCT AGATATCATT GATGTGAAAG TCACCGACGA AAATGGTAAA

GATGTTACAG CTAACGGCAC AGTAACACAA GAAAATAACA AAGTAACTTT TGAAATGAAC

AAACAAGCAG ACACCTATGA CTATTTAAGT GGTCATACGT ATACAATGAC TATCACCACT

AAAATTAAAA CTGACGCAAC GCACGAAGAA TTAGCGCCTT ACATTGAACA AGGCGGGATT

CCCAACCAAG CCGACTTAAA CTTTGGCAAT GAAGGTGACG TGTTACATTC CAACAAACCA

ACCGTAACAC CACCGCCAGT TGATCCAAAT ATTGCTAAAG ACGTAGAAGG ACAAGAACAT

TTAGATTTAA CCAACCGCGA TCAAGAATTT AAATGGAACG TCAAAACAGC TTTCGGTAAC

GAAACAAGCA CTTGGACCCA ACCCAGCATC GTAGATGACA TTAATAAAGT GTTAGACATC

ACTGATGTAA AAGTCACAGA TGAAAATGGT AAAGATGTTA CAGCTAACGG CAAAGTAACA

CAAGAAAATA ACAAAGTAAC TTTTGAAATG AACAANCAAG CNGACACCTA TGACTATTTA

AGTCGTCATA CGTACACAAT GACCATTACT ACTAAAATCA AAGCTAGCGC AACGGACGAA

GAATTAGCAC CTTATATTGA ACAACGTGGC ATTCCCAACC AAGCCGACTT GAACTTTGGC

AACGAAGGTG ACGTGTTGCA TTCCAACAAA CCAACCGTAA CACCACCTGC ACCAACCCCA

GAAGATCCAA CCATTACAAA AGATATCGAA CCCCAAGAAC ATTTACATTT AACCAACCGT

GACCAAGAAT TTAAATGGAA CGTCAAAACA GCTTTCGGTA ACGAAACAAG CACATGGACC

CAACCCAGCA TGGTGGATGA CATTAATAAA GTCTTAGACA TCACAGACGT GAAAGTTNCT

GANGAAAATG GCAAAGATGT TACAGATAAT GGCATAGTAA CACAAGAAAA TAACAAAGTA

ACTTTTACTA TGAACAAAAA AGATGACAGC TACTOTTACT TAGCTGGTCA TACATACACA

ATGACTATTA CCACTAAAAT TAAAACTGAC GCAACGGATG AAGAATTACC GCCTTATATT

GAACAACGCG GGATTCCCAA CCAAGCCGAC TTAAACTTTG GCAACGAAGG TGACGTCTTG

CATTCCAACA AGCCAACCGT AACACCGCCT GCACCAACGC CAGAAGACCC AAAAAAACCT

GAACCTAAAC AACCGCTAAA ACCGAAAAAA CCGTTGACGC CTACAAATCA TCAAGCACCA

ACGAACCCAG TCAATTTTCG AAAATCAGCA AGTAAAGGAA TTCATTTACC AATGACTAAT

ACAACAGTAA ATCCACTTTA CATGATCGCA GGTTTAATTG TCCTTATAGT GGCTATTAGC

TTTGGCATAA CAAAAAATAA AAAAAGAAAA AATTAC

EF067-2 (SEQ ID NO:254)

ME KKATKLLJSTM VTVAGTVVGN FSPTLALAEE AVKAGDTEGM TNTVKVKDDS

LADCKRILEG QATFPVQAGE TEPVDLVVVE DASGSFSDNF PHVRQAIDEV VQCLSDQDRV

MLASYRGGKQ FMFPDGKTKI NSADYDMNVR VNTQLTYDKS QFVSGFGDVR TYGGTPTAPG

LKLALDTYNQ THGDLTNRKT YFLLVTDGVA NTRLDGYLHK TNTNDSTNEY PDPRHPLQVS

VEYSNDYQGA AAEVLALNQE ITNQGYEMIN AYWESVESLS SVNSYFDKYK TEVGPFVKQE

LQQGSSTPED FITSQSIDDF TTQLKQIVKD RLAQSTPATA ELTIANQEDI QSATATDDAG

NDVPVQTNGQ TISATETEGY VCNITIHYEV KENTAIDAAT LVSSCTMNQG TIAKEFPEAT

IPKNDNAHAC DVTPEDPTIT KUTENQEELD LTNREDSFDW HVKTAFGNET STWTQASMVD

DINKVLDIID VKVTDENGKD VTANGTVTQE NNKVTFEMNK QADSYDYLSG HTYTMTITTK

IKTDATDEEL APYTEQOGIP NQADLNFGNE GDVLHSNKPT VTPPPVDPNI AKDVEGQEHL

DLTNRDQEFK WNVKTAFGNE TSTWTQASMV DDINKVLDIT DVKVTDENGK DVTANGKVTQ

ENNKVTFEMN XQADSYDYLS GHTYTMTITT KIKASATDEE LAPYIEQGGI PNQADLNEGN

ECDVLHSNKP TVTPPAPTPE DPTITKDIEG QEHLDLTNRD QEFKWNVKTA FCNETSTWTQ

ASMVDDTNKV LDITDVKVXX ENGKDVTDNG IVTQENNKVT FTMNKKDDSY SYLAGHTYTM

TITTKIKTDA TDEELAPYIE QGGIPNQADL NFGNEGDVLH SNKPTVTPPA PTPEDPKKPE

PKQPLKPKKP LTPTNHQAPT NPVNFGKSAS KGIHLPMTNT TVNPLYMIAG LIVLIVAISF

GITKNKKRKN

EF067-3 (SEQ ID NO:255)

GOT AGATATCATT GATGTGAAAG TCACCGACGA AAATGGTAAA

GATOTTACAG CTAACGGCAC AGTAACACAA GAAAATAACA AAGTAACTTT TGAAATGAAC

AAACAAGCAG ACAGCTATGA CTATTTAAGT GGTCATACGT ATACAATGAC TATOACCACT

AAAATTAAAA CTGACGCAAC GGACGAAGAA TTAGCGCCTT ACATTGAACA AGGCGGGATT

CCCAACCAAG CCGACTTAAA CTTTGGCAAT GAAGGTGACG TOTTACATTO CAACAAACCA

ACCGTAACAC CACCGCCAGT TGATCCAAAT ATTGCTAAAG ACGTAGAAGG ACAAGAACAT

TTAGATTTAA CCAACCGCGA TCAAGAATTT AAATGGAACG TCAAAACAGC TTTCGGTAAC

GAAACAAGCA OTTOGACOCA AGCCAGCATG GTAGATGACA TTAATAAAGT OTTAGACATO

ACTGATGTAA AAGTCACAGA TGAAAATGGT AAAGATGTTA CAGCTAACGG CAAAGTAACA

CAAGAAAATA ACAAAGTAAC TTTTGAAATG AACAANCAAG ONGACAGOTA TGACTATTTA

AGTGGTCATA CGTACACAAT GACCATTACT ACTAAAATCA AAGCTAGCGC AACGGACGAA

GAATTAGCAC CTTATATTGA ACAAGGTGGC ATTCCCAACC AAGCCGACTT GAACTTTGGC

AACGAAGGTG ACGTGTTGCA TTCCAACAAA CCAACCGTAA CACCACCTGC ACCAACGCCA

GAAGATCCAA CGATTACAAA AGATATCGAA GGCCAAGAAC ATTTAGATTT AACCAACCGT

GACCAAGAAT TTAAATGGAA CGTCAAAACA GCTTTCGCTA ACGAAACAAG CACATGGACC

CAAGCCAGCA TGGTGGATGA CATTAATAAA OTOTTAGACA TOACAGACOT GAAAGTTNCT

GANGAAAATG GCAAAGATGT TACAGATAAT GGCATAGTAA CACAAGAAAA TAACAAAGTA

ACTTTTACTA TGAACAAAAA AGATOACAGO TACTCTTACT TAGCTGGTCA TACATACACA

ATGACTATTA CCACTAAAAT TAAAACTGAC GCAACGGATG AAGAATTAGC GCCTTATATT

GAACAAGGCG GGATTCCCAA CCAAGCCGAC TTAAACTTTG GCAACGAAGG TGACGTGTTG

CATTCCAACA AGCCAACCGT AACACCGCCT GCACCAACGC CAGAAGACCC AAAAAAACCT

GAACCTAAAC AACCGCTAAA ACCGAAAAAA CCGTTGACGC CTACAAATCA TCAAGCACCA

ACGAACCCAG TCAATTTTGG AAAATCAGCA AGTAAAGGAA TT

EF067-4 (SEQ ID NO:256)

VLDIID VKVTDENGKD VTANGTVTQE NNKVTFEMNK QADSYDYLSG HTYTMTITTK

IKTDATDEEL APYTEQGGIP NQADLNFGNE GDVLHSNKPT VTPPPVDPNI AKDVEGQEHL

DLTNRDQEFK WNVKTAFGNE TSTWTQASMV DDTNKVLDTT DVKVTDENGK DVTANGKVTQ

ENNKVTFEMN XQADSYDYLS GHTYTMTTTT KIKASATDEE LAPYTEQOGI PNQADLNFGN

EGDVLHSNKP TVTPPAPTPE DPTITKDIEG QEHLDLTNRD QEFKWNVKTA FGNETSTWTQ

ASMVDDINKV LDITDVKVXX ENGKDVTDNG IVTQENNKVT FTMNKKDDSY SYLAGHTYTM

TITTKIKTDA TDEELAPYTE QGGIPNQADL NFGNEGDVLH SNKPTVTPPA PTPEDPKKPE

PKQPLKPKKP LTPTNHQAPT NPVNFGKSAS KGIH

EF068-1 (SEQ ID NO:257)

TAGGGGAAGC TAATGATCTT GGTATTTATC GTTTATTTTA AAGAAAAGAG GGACGATCAG

ATGAAAAAGA AAATTGTTGA GGATTTTAAT CGGAAAAGTC AGCATAAAAA ATGGACAAAA

CGCAAGATGC TTAATTTAGC AATATCAAGT GGTTTATTAT TTACGTCATT AGCAATCCCT

GTAAGTATAG CTGTTACCTC TGGCACAATC AGTGCATCAG CAGCGGTCTT GGATATCGAA

CTATTATCAA ATGTTACGTC AAATAATGAC AGTGGCACTT CAACGAGTAA TCGTTGGACA

GCCGCAAACC AAAATCAACC AGTTAATTTC ACGGTTTCTG GTGGCGCTTT AGCAGATGCT

TCCGCTGTGT TTAGTGGACA AAAACAAGCG GTGTTAGTGG TTCCTCCTGA GTTAAGAGGA

AATGTAGCTG CAGOAGGOAG CGCAGCAATC AATACCAATG TCACGATTGA TCTTTCAAAA

GTTACTTTTT TGACTGCCGT TTTGAATGCA GCCAATGATT TAACCAATGT GATTACTCAA

ATTACCAGTG GGGCGTTAGG GAATTTAACT GGTGTTGATA TTGATTTGAC GGAAGTGAAT

CGTCAATTGG AATTAGTTAA TAACATTGAA AACTTAGGTG CTGCTTCATT TACAGCTCCG

GAAACGTTAG CAGCTGACGG CTCATACATT AGTGCACCGA TTAGTGATGG TTTAGGGTTA

GTTTTAGCCC AAAATGTTTC AAACATCTTA CAAGATTTGA ATGCGGCAGT TCAAGCTTTG

GAGGCAAAAG GTACCAGTAT CCCAAGTAAT CTTGTCGCCG CAGCTATAAA TGCAGCCTTG

CTTCCTGTCA AAGGCACGGT AAACGTGGCT GTTTCAGGTG CTTTGCCTTT ATTAGCGGTT

GGTGGTTCAG GCGTAAATGA GTTAGTGGAT GCTTCTTTAC TAGGCACAAC CACGGTTACT

TTACCAACTA CCGTTTCAAC ACCTCAAAAT TTATCCAATA ATTTAGATGC TCGTTTTGTA

GGAACAGTCG TTCAAACAGA TCTTTTAGAC GTTAATTTAT TAGCAACAGC AGACCGTGTA

TCCAACATTT ATTTTGCTGC AGGCACTACT AGTGAAGTAA CCGCACCAAC AATCACAGGA

GTAACAGGTA ATTCAACAGC AGGTTACGAA GTTAAAGGAA CTGCCGATGC CAATGCCACG

GTTGAAATCC GAAATGCAGG AGGCACCGTA ATAGGCACAG GTACCGCTGA TGGGACAGGA

GCGTTTACAG TTACCGTTCC CGCAGGTGAA GCACGCGCCA ATGAAACGTT AACCGCCGTA

GCGAAAAACG CCAGCGGNAC AGAAAGNACG CCAACAACGT TCCAAACNCC AGCGGATGAA

GCAACCGTAA CCGCACCAAC AATCACAGGA GTGACAGGTA ATTCAACGGC AGGTTACGAA

GTTAAAGGAA CTGCCGATGC CAATGCCACG GTTGAAATCC GAAATGCAGG AGGCACCGTA

ATAGOCACAG GTACCGCTGA TGGGACAGGA GCGTTTACAG TTACCGTTCC CGCAGGTGAA

GCAGGTGCCA ATGAAACGTT AACCGCCGTA GCGAAAAACG CCAGCGGCAC ACAAAGTACG

CCAACAACGT TCCAAACACC AGCGGATGAA GCAACCGTAA CCGCACCAAC AATCACAGGA

GTGACAGGTA ATTCAACAGC AGGTTACGAA GTTAAAGGAA CTGCCGATGC CAATGCCACG

GTTGAGATCC GAAATGCAGG AGGTGCCGTG ATAGGTACAG GTACTGCTGA TGGGACAGGG

GCATTTACAG TTACCATTCC CGCAGGTGAA GCAGGTGCGA ATGAAACGTT AACCGCCGTA

GCGAAAAACG CCAGCGGTAC AGAAAGTACG CCAACAACGT TCCAAACGCC AGCGGATCCT

AATACGCCCG TGGCGACGCC AATTGTTGAG ACTGTAACAG GTAGTACAAC AAAAGGCTAT

GAGGTCAAAG GGACTGCTGA AGTTGGCACC ACCATTGAGG TTCGCGATGC AGCTGGCACG

GTCCTTGGTA CTGCAACAAC TGGAACTGAC CGAAAATATA CAGTGACTTT AGATTCAGGA

ACAGCAACAG CAAATCAAAC GCTGAGCGTT GTAGCGAAAA ACGCTAGTGG CACGGAAAGT

CAACCAGCAA CGGCGACAAC ACCAGCTGAT GTCACTGCAC CAACAGTTGA TAACATCACA

GGCAACTCTG GTTCGGGTTA TGAAATTACA GGAACAGCAG ACCCTAACAC AACAATCGAA

GTTCGTGATC CATCTCGGGC AGTCATTGCT ACAGGTACCT CTGATGCGAA TGGTGATTTT

ACTGTAACGC TACCAACGGG AACGACCAAT CCTGGGGATA CCTTAACAGT GATTGGAAAG

GATAACGCGG GAAATGAAAG TCAACCGACT GAAGTCCTTG TTCCTGCTGA TGCCACGGTT

ACAGCACCAA CTGTAACAGG AGTAACAGGT AATTCAGTTG CTGGTTATCA GGTGACAGGC

ACCGCTGATC CGAATGCTAC CATCGAAATT CGTGATGCAG ATGGGAACGT GATTGCAACA

GGGACTGCCG ATGGGACTGG TTCCTTTGCT GTGAACCTTC CAGCTGGGAC GGCAAATGCG

AATCAAACAT TGACAGCGTT AGCCAAAGAT CCTGCTGGCA ATACAAGTAC ACCGACAACC

TTCCAAACAC CAGCAGATGA AGTAGTGGCA CCGCCAAGTG TCGACAAAGT TACTGGGAAT

ACAACACAAG GATATCAAGT GACAGGTACC GCTGAACTTG GCACCACCAT TGAAGTTCGT

GCAACAGACG GAACAGTTTT AGGCACCGCA ACAACTGGAC CGACTGGCCA ATATACTGTG

ACGTTAGCTT CAGGAAAAGC AACAGCTAAA CAAACAGTGA ATGTAGTTGC TAAAAATGAT

ACTGGACTTG AGAGTCAACC AACTACAGCT ATGACACCCG CTGATGTTAC CACACCAACA

ATTGGTGACA TTACTGGAGA TTCAACAACT GGTTATGAAA TCACTGGGAC CGCGGACCCT

AATACCACCA TTGAAGTACG GAACCCAGAT GGAACAATTA TTGGTACAAC GACAACGGAT

GATCAAGGAA ACTTTACTGT GGACCTTCCA GCGGGAGCCG CTAATCCTGG TGATACATTA

ACAGTTGTTG GAAAAGACGG TGACGGCAAT CAAAGTCAAC CAACGGAAGT GACGGTCCCT

GAAGATGCAA CCGTAGCAGC ACCAACTGTG ACGACTGTTA CAGGAACAAC TGCCACTGGG

TATCAAGTAA CCGGCACGGC AGAGCCAAAT GTCACCATTG AGATTCACAA TGAAGCAGGT

TTAGTTATTG CTACGGGAAC GACTGATGGT GCTGGCGCAT TTACAATCAC TCTTCCGACG

GGCACAGCAA CAGCTAACGA AGCCTTAACT GCCATTGCGA AAGATGCTGC TGGGAAAGAA

AGTAATCCGA CTGCTTTCAA AACACCTGCT GATCCAGATG CACCAGTCGC GACACCTACT

GTTGACAAAA TCACTGGTAG CACGACAAAC GGCTATCAAG TAGTAGGAGC AGCAGAAGTT

GGTACAACAG TTGAGGTGCG TGACGCCGAT GGCACAGTCC TTGGCATGGC AACTACTGGA

ACTGATGGCA AATACACAGT GACTTTAGAG CCAGGGAAGG CCTCAGCTAA CGAAACAATA

ACTGTCGTAG CGAAAAATGC AACAGGAAAA GAAAGTCAGC CAGCTACAGC AACTACACCA

GTCGACTTAG CCACACCAAC CATTGATTCT ATTACCGGAA ATTCTAGTAA AGGTTACGAA

ATCACTGGAA CGGCGGAGCC AAAAACCACT ATTGATGTCC GTGACGCAGA CGGAACCATC

ATTGCTGCTA CAACTGCTAA CGAAACCGGC CAATATACGG TGACTCTACC AGCTGGCGTA

GTGACACCAG GAGAAACGAT TACGATTATT AGCAAAGATG GCGCAGGTAA TGAAAGTCAA

CCAGCTACAC CCGTTATTCC AGCGGATGTT GTTTTAGCGG CGCCAACTAT TACGAAGGTT

GAAGGAAACA AAGCCAATGG CTATACAGTC ACTGGAACTG CTGATCCAAA TGTCACGGTT

CAATTTTACA ATAGCAGTGA ACAATTATTG GCAAGTGCCA ATACAACTAC TGGAGCTACC

TTCTCCGTTC ATATTGCAGC AGGGTTAGCA ACAGAAAAAG AAACGTTAAC CGCACTAACC

ACAGATACAC AAGGAAATGT GAGTCCTAAA ACCACATTTA TGACGCCAGC CGATATTACG

GGAGAACCAG AGATTAAAAT TGCGGCACCA ACTGTTTCTT CAGTTTTAGG AACGTCTAAA

GCCGGCTACC TCATCAAAGG AACAGCTGAA CCAAACCGAA TCATTCAAAT TAGTAACCGA

CTATTAAGAA GTGTGATTGC TGTAGGTGCC ACCGATGCTG AAGGCAACTT CGCTATCCAA

TTAACAGCGG GACAAGCGAC TGCTCAACAA AGTTTACTTG CGACAGCTAC CGATGGCGCA

GGACATTACA GTACGGCTAC AACCTTCATG ACGCCAGCCG ACCCAACGAA TCCTGGAGGA

GGCAATGGTA ACACTGGCGG AAATAACGGC AATACAGGCG GCAATACAGG AAACAATGGC

GCAACTGGCG GGAATAATGG GAATGGTTCA AACACAGGTT CAAATCCAAA TGGAGGTTCT

GGTTTAGGCA CAACAGGTTC TGGCTTAGGT TCACTAGGCA ATGGCCTCGG TACAAATGGT

AGTGGCTACC ACCCTAAACT AAGTACCATC ACTTATGGCA CTGGAAATCA CGGGAAAACA

GGCTACTTAC CTAGCACAGG TGAAAAAGAG TCTTCAGCCG TGACAACAAG TTTGTTTCGC

GCCTTTGTCG CACTCCTTGC GAGCATGGGA ATCATCAAAC GCAAACGTAA AAACTAG

EF068-2 (SEQ ID NO:258)

M KKKIVEDFNR KSQHKKWTKR KMLNLAISSG LLFTSLAIPV

SIAVTSCTIS ASAAVLDIEL LSNVTSNNDS GTSTSNRWTA ANQNQPVNFT VSGGALADAS

AVFSGQKQAV LVVPPELRGN VAAAGSAAIN TNVTIDLSKV TFLTAVLNAA NDLTNVITQI

TSGALGNLTG VDIDLTEVNR QLELVNNIEN LGAASFTAPE TLAADGSYIS APISDGLGLV

LAQNVSNILQ DLNAAVQALE AKGTSIPSNL VAAAINAALL PVKGTVNVAV SGALPLLAVG

GSGVNELVDA SLLGTTTVTL PTTVSTPQNL SNNLDARFVG TVVQTDLLDV NLLATADGVS

NIYFAAGTTS EVTAPTITGV TGNSTAGYEV KGTADANATV EIRNAGGTVI GTGTADGTGA

FTVTVPAGEA GANETLTAVA KNASGTEXTP TTFQTPADEA TVTAPTITGV TGNSTAGYEV

KGTADANATV EIRNAGGTVI GTGTADGTGA FTVTVPAGEA GANETLTAVA KNASGTESTP

TTFQTPADEA TVTAPTITGV TGNSTAGYEV KGTADANATV EIRNAGGAVI GTGTADGTGA

FTVTIPAGEA GANETLTAVA KNASGTESTP TTFQTPADPN TPVATPIVET VTCSTTKGYE

VKGTAEVGTT IEVRDAAGTV LGTATTGTDG KYTVTLDSGT ATANQTLSVV AKNASGTESQ

PATATTPADV TAPTVDNITG NSGSGYEITG TADPNTTIEV RDPSGAVIGT GTSDANGDFT

VTLPTGTTNP GDTLTVIGKD NAGNESQPTE VLVPADATVT APTVTGVTCN SVAGYQVTGT

ADPNATIEIR DADGNVIATG TADGTGSFAV NLPAGTANAN ETLTALAKDP AGNTSTPTTF

QTPADEVVAP PSVDKVTGNT TQGYQVTGTA ELGTTIEVRA TDGTVLGTAT TGPTGQYTVT

LASGKATAKQ TVNVVAKNDT GLESQPTTAM TPADVTTPTI GDITGDSTTG YEITGTADPN

TTIEVRNPDG TIIGTTTTDD QGNFTVDLPA GAANPGDTLT VVGKDGDGNE SQPTEVTVPE

DATVAAPTVT TVTGTTATGY QVTGTAEPNV TIEIHNEAGL VIATGTTDGA CAFTITLPTG

TATANEALTA IAKDAAGKES NPTAFKTPAD PDAPVATPTV DKITGSTTNG YQVVGAAEVG

TTVEVRDADG TVLGMATTGT DGKYTVTLEP GKASANETIT VVAKNATGKE SQPATATTPV

DLATPTIDSI TGNSSKGYEI TGTAEPKTTI DVRDADGTII AATTANETGQ YTVTLPAGVV

TPGETITIIS KDGAGNESQP ATAVIPADVV LAAPTITKVE GNKANGYTVT GTADPNVTVQ

FYNSSEQLLA SGNTTTGGTF SVHIAAGLAT EKETLTALTT DTQGNVSPKT TFMTPADITG

EPEIKIAAPT VSSVLGTSKA GYLIKGTAEP NRIIQISNRL LRSVIAVGAT DAEGNFAIQL

TAGQATAQQS LLATATDGAG HYSTATTFMT PADPTNPGGG NGNTGGNNGN TGGNTGNNGA

TGGNNCNGSN TGSNPNGGSG LGTTGSGLGS LGNGLGTNGS GYHPKLSTIS YGTGNHGKTG

YLPSTGEKES SAVTTSLFGA EVALLASMGI IKRKRKN

EF068-3 (SEQ ID NO:259)

CTC TGGCACAATC AGTGCATCAG CAGCGGTCTT GGATATCGAA

CTATTATCAA ATGTTACGTC AAATAATGAC AGTGGCACTT CAACGAGTAA TCGTTGGACA

GCCGCAAACC AAAATCAACC AGTTAATTTC ACGGTTTCTG GTGGCGCTTT AGCAGATGCT

TCCGCTGTGT TTAGTGGACA AAAACAAGCG GTGTTAGTGG TTCCTCCTGA GTTAAGAGGA

AATGTAGCTG CAGCAGGCAG CGCAGCAATC AATACCAATG TCACGATTGA TCTTTCAAAA

GTTACTTTTT TGACTGCCGT TTTGAATGCA GCCAATGATT TAACCAATGT GATTACTCAA

ATTACCAGTG GGGCGTTAGG GAATTTAACT GGTGTTGATA TTGATTTGAC GGAAGTGAAT

CGTCAATTCG AATTAGTTAA TAACATTGAA AACTTAGGTG CTGCTTCATT TACAGCTCCG

GAAACGTTAG CAGCTGACGG CTCATACATT AGTGCACCGA TTAGTGATGG TTTAGGGTTA

GTTTTAGCCC AAAATGTTTC AAACATCTTA CAAGATTTGA ATGCGGCAGT TCAAGCTTTG

GAGGCAAAAG GTACCAGTAT CCCAAGTAAT CTTGTCGCCG CAGCTATAAA TGCAGCCTTG

CTTCCTGTCA AAGGCACGGT AAACGTGGCT GTTTCAGGTG CTTTGCCTTT ATTAGCGGTT

GCTGGTTCAG GCGTAAATGA GTTAGTGGAT GCTTCTTTAC TAGGCACAAC CACGGTTACT

TTACCAACTA CCGTTTCAAC ACCTCAAAAT TTATCCAATA ATTTAGATGC TCGTTTTGTA

GGAACAGTCG TTCAAACAGA TCTTTTAGAC GTTAATTTAT TAGCAACAGC AGACGGTGTA

TCCAACATTT ATTTTGCTGC AGGCACTACT AGTGAACTAA CCGCACCAAC AATCACAGGA

GTAACAGGTA ATTCAACAGC AGGTTACGAA GTTAAAGGAA CTGCCGATGC CAATGCCACG

GTTGAAATCC GAAATGCAGG AGGCACCGTA ATAGGCACAG GTACCGCTGA TGGGACAGGA

GCGTTTACAG TTACCGTTCC CGCAGGTGAA GCAGGCGCCA ATGAAACGTT AACCGCCGTA

GCGAAAAACG CCAGCGGNAC AGAAAGNACG CCAACAACGT TCCAAACNCC AGCGGATGAA

GCAACCGTAA CCGCACCAAC AATCACAGGA GTGACAGGTA ATTCAACCGC AGGTTACGAA

GTTAAAGGAA CTGCCGATGC CAATGCCACG GTTGAAATCC GAAATGCAGG AGGCACCGTA

ATAGGCACAG GTACCGCTGA TGGGACAGGA GCGTTTACAG TTACCGTTCC CGCAGGTGAA

GCAGGTGCCA ATGAAACGTT AACCGCCGTA GCGAAAAACG CCAGCGGCAC AGAAAGTACC

CCAACAACGT TCCAAACACC AGCGGATGAA GCAACCGTAA CCGCACCAAC AATCACAGGA

GTGACAGGTA ATTCAACAGC AGGTTACGAA GTTAAAGGAA CTGCCGATGC CAATGCCACG

GTTGAGATCC GAAATGCAGG AGGTGCCGTG ATAGGTACAG GTACTGCTGA TGGGACAGGG

GCATTTACAG TTACCATTCC CGCAGGTCAA GCAGGTGCGA ATGAAACGTT AACCGCCGTA

GCGAAAAACG CCAGCGGTAC AGAAAGTACG CCAACAACGT TCCAAACGCC

EF068-4 (SEQ ID NO:260)

TSGTIS ASAAVLDIEL LSNVTSNNDS GTSTSNRWTA ANQNQPXTNFT VSGGALADAS

AVFSGQKQAV LVVPPELRGN VAAAGSAAIN TNVTIDLSKV TFLTAVLNAA NDLTNVITQI

TSGALGNLTG VDIDLTEVNR QLELVNNIEN LGAASFTAPE TLAADGSYIS APISDGLGLV

LAQNVSNILQ DLNAAVQALE AKGTSIPSNL VAAAINAALL PVKGTVNVAV SGALPLLAVG

GSGVNELVDA SLLGTTTVTL PTTVSTPQNL SNNLDARFVG TVVQTDLLDV NLLATADGVS

NIYFAAGTTS EVTAPTITGV TGNSTAGYEV KGTADANATV EIRNAGGTVI GTGTADGTGA

FTVTVPAGEA GANETLTAVA KNASGTEXTP TTFQTP

EF069-1 (SEQ ID NO:261)

TAGGGGAACC TAATGATCTT GGTATTTATC GTTTATTTTA AAGAAAAGAG GGACGATCAG

ATCAAAAAGA AAATTGTTGA GGATTTTAAT CGGAAAAGTC AGCATAAAAA ATGGACAAAA

CGCAAGATGC TTAATTTAGC AATATCAAGT GGTTTATTAT TTACGTCATT AGCAATCCCT

GTAAGTATAG CTGTTACCTC TGGCACAATC AGTGCATCAG CAGCGGTCTT GGATATCGAA

CTATTATCAA ATGTTACGTC AAATAATGAC AGTGGCACTT CAACGAGTAA TCGTTGGACA

GCCGCAAACC AAAATCAACC AGTTAATTTC ACGGTTTCTG GTGGCGCTTT AGCAGATGCT

TCCGCTGTGT TTAGTGGACA AAAACAAGCG GTGTTAGTGG TTCCTCCTGA GTTAAGAGGA

AATGTAGCTG CAGCAGGCAG CGCAGCAATC AATACCAATG TCACGATTGA TCTTTCAAAA

GTTACTTTTT TGACTGCCGT TTTGAATGCA GCCAATGATT TAACCAATGT GATTACTCAA

ATTACCAGTG GGGCGTTAGG GAATTTAACT GGTGTTGATA TTGATTTGAC GGAAGTGAAT

CGTCAATTGG AATTAGTTAA TAACATTGAA AACTTAGGTG CTGCTTCATT TACAGCTCCG

GAAACGTTAG CAGCTGACGG CTCATACATT AGTGCACCGA TTAGTGATGG TTTAGGGTTA

GTTTTAGCCC AAAATGTTTC AAACATCTTA CAAGATTTGA ATGCGGCAGT TCAAGCTTTG

GAGGCAAAAG GTACCAGTAT CCCAAGTAAT CTTGTCGCCG CAGCTATAAA TGCAGCCTTG

CTTCCTGTCA AAGGCACGGT AAACGTGGCT GTTTCAGGTG CTTTGCCTTT ATTAGCGGTT

GGTGGTTCAG GCGTAAATGA GTTAGTGGAT GCTTCTTTAC TAGGCACAAC CACGGTTACT

TTACCAACTA CCGTTTCAAC ACCTCAAAAT TTATCCAATA ATTTAGATGC TCGTTTTGTA

GGAACAGTCG TTCAAACAGA TCTTTTAGAC GTTAATTTAT TAGCAACAGC AGACGGTGTA

TCCAACATTT ATTTTGCTGC AGGOACTACT AGTGAAGTAA CCGCACCAAC AATCACAGGA

GTAACAGGTA ATTCAACAGC AGGTTACGAA GTTAAAGGAA CTGCCGATGC CAATGCCACG

GTTGAAATCC GAAATGCAGG AGGCACCGTA ATAGGCACAG GTACCGCTGA TGGGACAGGA

GCGTTTACAG TTACCGTTCC CGCAGGTGAA GCAGGCGCCA ATGAAACGTT AACCGCCGTA

GCGAAAAACG CCAGCGGNAC AGAAAGNACG CCAACAACGT TCCAAACNCC AGCGGATGAA

GCAACCGTAA CCGCACCAAC AATCACAGGA GTGACAGGTA ATTCAACGGC AGGTTACGAA

GTTAAAGGAA CTGCCGATGC CAATGCCACG GTTGAAATCC GAAATGCAGG AGGCACCGTA

ATAGGCACAG GTACCGCTGA TGGGACAGGA GCGTTTACAG TTACCGTTCC CGCAGGTGAA

GCAGGTGCCA ATGAAACGTT AACCGCCGTA GCGAAAAACG CCAGCGGCAC AGAAAGTACG

CCAACAACGT TCCAAACACC AGCGGATGAA GCAACCGTAA CCGCACCAAC AATCACAGGA

GTGACAGGTA ATTCAACAGC AGGTTACGAA GTTAAAGGAA CTGCCGATGC CAATGCCACG

GTTGAGATCC GAAATGCAGG AGGTGCCGTG ATAGGTACAG GTACTGCTGA TGGGACAGGG

GCATTTACAG TTACCATTCC CGCAGGTGAA GCAGGTGCGA ATGAAACGTT AACCGCCGTA

GCGAAAAACG CCAGCGGTAC AGAAAGTACG CCAACAACGT TCCAAACGCC AGCGGATCCT

AATACGCCCG TGGCGACGCC AATTGTTGAG ACTGTAACAG GTAGTACAAC AAAAGGCTAT

GAGGTCAAAG GGACTCCTGA AGTTGGCACC ACCATTGAGG TTCGCGATGC AGCTGGCACG

GTCCTTGGTA CTGCAACAAC TGGAACTGAC GGAAAATATA CAGTGACTTT AGATTCAGGA

ACAGCAACAG CAAATCAAAC GCTGAGCGTT GTAGCGAAAA ACGCTAGTGG CACGGAAAGT

CAACCAGCAA CGGCGACAAC ACCAGCTGAT GTCACTGCAC CAACAGTTGA TAACATCACA

GGCAACTCTG GTTCGGGTTA TGAAATTACA GGAACAGCAG ACCCTAACAC AACAATCGAA

GTTCGTGATC CATCTGGGGC AGTCATTGGT ACAGGTACCT CTGATGCGAA TGGTGATTTT

ACTGTAACGC TACCAACGGG AACGACCAAT CCTGGGGATA CGTTAACAGT GATTGGAAAG

GATAACGCGG GAAATGAAAG TCAACCGACT GAAGTCCTTG TTCCTGCTGA TGCCACGGTT

ACAGCACCAA CTGTAACAGG AGTAACAGGT AATTCAGTTG CTGGTTATCA GGTGACAGGC

ACCGCTGATC CGAATGCTAC CATCGAAATT CGTGATGCAG ATGGGAACGT GATTGCAACA

GGGACTGCCG ATGGGACTGG TTCCTTTGCT GTGAACCTTC CAGCTGGGAC GGCAAATGCG

AATCAAACAT TGACAGCGTT AGCCAAAGAT CCTGCTGGCA ATACAAGTAC ACCGACAACC

TTCCAAACAC CAGCAGATGA AGTAGTGGCA CCGCCAAGTG TCGACAAAGT TACTGGGAAT

ACAACACAAG GATATCAAGT GACAGGTACC GCTGAACTTG GCACCACCAT TGAAGTTCGT

GCAACAGACG GAACAGTTTT AGGCACCGCA ACAACTGGAC CGACTGGCCA ATATACTGTG

ACGTTAGCTT CAGGAAAAGC AACAGCTAAA CAAACAGTGA ATGTAGTTGC TAAAAATGAT

ACTGGACTTG AGAGTCAACC AACTACAGCT ATGACACCCG CTGATGTTAC CACACCAACA

ATTGGTGACA TTACTGGAGA TTCAACAACT GGTTATGAAA TCACTGGGAC GGCGGACCCT

AATACCACCA TTGAAGTACG GAACCCAGAT GGAACAATTA TTGGTACAAC GACAACGGAT

GATCAAGGAA ACTTTACTGT GGACCTTCCA GCGGGAGCCG CTAATCCTGG TOATACATTA

ACAGTTGTTG GAAAAGACGG TGACGGCAAT GAAAGTCAAC CAACGGAAGT GACGGTCCCT

GAAGATGCAA CCGTAGCAGC ACCAACTGTG ACGACTGTTA CAGGAACAAC TGCCACTGGG

TATCAAGTAA CCGGCACGGC AGAGCCAAAT GTCACCATTG AGATTCACAA TGAAGCAGGT

TTAGTTATTG CTACGGGAAC GACTGATGGT GCTGGCGCAT TTACAATCAC TCTTCCGACG

GGCACAGCAA CAGCTAACGA AGCCTTAACT GCCATTGCGA AAGATGCTGC TGGGAAAGAA

AGTAATCCGA CTGCTTTCAA AACACCTGCT GATCCAGATG CACCAGTCGC GACACCTACT

GTTGACAAAA TCACTGGTAG CACGACAAAC GGCTATCAAG TAGTAGGAGC AGCAGAAGTT

GGTACAACAG TTGAGGTGCG TGACGCCGAT GGCACAGTCC TTGGCATGGC AACTACTGGA

ACTGATGCCA AATACACAGT GACTTTAGAG CCAGGGAAGG CCTCAGCTAA CGAAACAATA

ACTGTCGTAG CGAAAAATGC AACAGGAAAA GAAAGTCAGC CAGCTACAGC AACTACACCA

GTCGACTTAG CCACACCAAC CATTGATTCT ATTACCGGAA ATTCTAGTAA AGGTTACGAA

ATCACTGGAA CGGCGGAGCC AAAAACCACT ATTGATGTCC GTGACGCAGA CGGAACCATC

ATTGCTGCTA CAACTGCTAA CGAAACCGGC CAATATACGG TGACTCTACC AGCTGGCGTA

GTGACACCAG GAGAAACGAT TACGATTATT AGCAAAGATG GCGCAGGTAA TGAAAGTCAA

CCAGCTACAG CCGTTATTCC AGCGGATGTT GTTTTAGCGG CGCCAACTAT TACGAAGGTT

GAAGGAAACA AAGCCAATGG CTATACAGTC ACTGGAACTG CTGATCCAAA TGTCACGGTT

CAATTTTACA ATAGCAGTGA ACAATTATTG GCAAGTGGCA ATACAACTAC TGGAGGTACC

TTCTCCGTTC ATATTCCAGC AGGGTTAGCA ACAGAAAAAG AAACGTTAAC CGCACTAACC

ACAGATACAC AAGGAAATGT GAGTCCTAAA ACCACATTTA TGACGCCAGC CGATATTACG

GGAGAACCAG AGATTAAAAT TGCGGCACCA ACTGTTTCTT CAGTTTTAGG AACGTCTAAA

GCCGGCTACC TCATCAAAGG AACAGCTGAA CCAAACCGAA TCATTCAAAT TAGTAACCGA

CTATTAAGAA GTGTGATTGC TGTAGGTGCC ACCGATGCTG AAGGCAACTT CGCTATCCAA

TTAACAGCGG GACAAGCGAC TGCTCAACAA AGTTTACTTG CGACAGCTAC CGATGGCGCA

GGACATTACA GTACGGCTAC AACCTTCATG ACGCCAGCCG ACCCAACGAA TCCTGGACGA

GGCAATGGTA ACACTGGCGG AAATAACGGC AATACAGGCG GCAATACAGG AAACAATGGC

GCAACTGGCG GGAATAATGG GAATGGTTCA AACACAGGTT CAAATCCAAA TGGAGGTTCT

GGTTTAGGCA CAACAGGTTC TGGCTTAGGT TCACTAGGCA ATGGCCTCGG TACAAATGGT

AGTGGCTACC ACCCTAAACT AAGTACCATC AGTTATGGCA CTGGAAATCA CGGGAAAACA

GGCTACTTAC CTAGCACAGG TGAAAAAGAG TCTTCAGCCG TGACAACAAG TTTGTTTGGC

GCCTTTGTCG CACTCCTTGC GAGCATGCGA ATCATCAAAC GCAAACGTAA AAACTAG

EF069-2 (SEQ ID NO:262)

M KKKIVEDFNR KSQHKKWTKR KMLNLAISSG LLFTSLAIPV

SIAVTSGTIS ASAAVLDIEL LSNVTSNNDS GTSTSNRWTA ANQNQPVNFT VSGGALADAS

AVFSGQKQAV LVVPPELRGN VAAAGSAAIN TNVTIDLSKV TFLTAVLNAA NDLTNVITQI

TSGALGNLTG VDIDLTEVNR QLELVNNIEN LGAASFTAPE TLAADGSYIS APISDGLGLV

LAQNVSNTLQ DLNAAVQALE AKGTSIPSNL VAAAINAALL PVKGTVNVAV SGALPLLAVG

GSGVNELVDA SLLGTTTVTL PTTVSTPQNL SNNLDARFVG TVVQTDLLDV NLLATADGVS

NIYFAAGTTS EVTAPTITGV TGNSTAGYEV KGTADANATV EIRNAGGTVI GTGTADGTGA

PIWTVPAGEA GANETLTAVA KNASGTEXTP TTFQTPADEA TVTAPTITGV TGNSTAGYEV

KGTADANATV EIRNAGGTVI GTGTADGTGA FTVTVPAGEA GANETLTAVA KNASGTESTP

TTFQTPADEA TVTAPTITGV TGNSTAGYEV KGTADANATV ETENAGGAVI GTGTADGTGA

FTVTIPAGEA GANETLTAVA KNASGTESTP TTFQTPADPN TPVATPIVET VTGSTTKGYE

VKGTAEVGTT TEVRDAAGTV LGTATTGTDG KYTVTLDSGT ATANQTLSVV AKNASGTESQ

PATATTPADV TAPTVDNITG NSGSGYEITG TADPNTTIEV RDPSGAVIGT GTSDANGDFT

VTLPTGTTNP GDTLTVIGKD NAGNESQPTE VLVPADATVT APTVTGVTGN SVAGYQVTGT

ADPNATIEIR DADGNVIATG TADGTGSFAV NLPAGTANAN ETLTALAKDP AGNTSTPTTF

QTPADEVVAP PSVDKVTGNT TQGYQVTGTA ELGTTIEVRA TDGTVLGTAT TGPTGQYTVT

LASGKATAKQ TVNVVAKNDT GLESQPTTAN TPADVTTPTI GDITGDSTTG YEITGTADPN

TTIEVENPDG TIIGTTTTDD QGNFTVDLPA GAANPGDTLT VVGKDGDGNE SQPTEVTVPE

DATVAAPTVT TVTGTTATGY QVTGTAEPNV TTETHNEAGL VIATGTTDGA GAFTITLPTG

TATANEALTA IAKDAAGKES NPTAFKTPAD PDAPVATPTV DKITGSTTNG YQVVGAAEVG

TTVEVRDADG TVLGMATTGT DGKYTVTLEP GKASANETIT VVAKNATGKE SQPATATTPV

DLATPTTDSI TGNSSKGYEI TGTAEPKTTI DVRDADGTII AATTANETGQ YTVTLPAGVV

TPGETITIIS KDGAGNESQP ATAVIPADVV LAAPTITKVE GNKANGYTVT GTADPNVTVQ

FYNSSEQLLA SGNTTTGGTF SVHTAAGLAT EKETLTALTT DTQGNVSPKT TFMTPADITG

EPETKIAAPT VSSVLGTSKA GYLIKGTAEP NRIIQISNRL LRSVIAVGAT DAEGNFAIQL

TAGQATAQQS LLATATDGAG HYSTATTFMT PADPTNPGGG NGNTGGNNGN TGGNTGNNGA

TGGNNGNGSN TGSNPNGGSG LGTTGSGLGS LGNGLGTNGS GYHPKLSTTS YGTGNHGKTG

YLPSTGEKES SAVTTSLFGA FVALLASMGI IKRKRKN

EF069-3 (SEQ ID NO:263)

AGGTGAA GCAGGTGCGA ATGAAACGTT AACCGCCGTA

GCGAAAAACG CCAGCGGTAC AGAAAGTACG CCAACAACGT TCCAAACGCC AGCGGATCCT

AATACGCCCG TGGCGACGCC AATTGTTGAG ACTGTAACAG GTAGTACAAC AAAAGGCTAT

GAGGTCAAAG GGACTGCTGA AGTTGGCACC ACCATTGAGG TTCGCGATGC AGCTGGCACG

GTCCTTGGTA CTGCAACAAC TGGAACTGAC GGAAAATATA CAGTGACTTT AGATTCAGGA

ACAGCAACAG CAAATCAAAC GCTGAGCGTT GTAGCGAAAA ACGCTAGTGG CACGGAAAGT

CAACCAGCAA CGGCGACAAC ACCAGCTGAT GTCACTGCAC CAACAGTTGA TAACATCACA

CGCAACTCTG GTTCGGGTTA TGAAATTACA GGAACAGCAG ACCCTAACAC AACAATCGAA

GTTCGTGATC CATCTGGGGC AGTCATTGGT ACAGGTACCT CTGATGCGAA TGGTGATTTT

ACTGTAACGC TACCAACGGG AACGACCAAT CCTGGGGATA CGTTAACAGT GATTGGAAAG

GATAACGCGG GAAATGAAAG TCAACCGACT GAAGTCCTTG TTCCTCCTGA TGCCACGGTT

ACAGCACCAA CTGTAACAGC AGTAACAGGT AATTCAGTTG CTGCTTATCA GGTGACAGGC

ACCGCTGATC CGAATGCTAC CATCCAAATT CGTGATGCAG ATGGGAACCT GATTGCAACA

GGGACTCCCG ATGCGACTGG TTCCTTTGCT GTGAACCTTC CAGCTGGGAC GGCAAATGCG

AATGAAACAT TGACAGCGTT AGCCAAAGAT CCTGCTGGCA ATACAAGTAC ACCGACAACC

TTCCAAACAC CAGCAGATGA AGTAGTGGCA CCGCCAAGTG TCGACAAAGT TACTGGGAAT

ACAACACAAG GATATCAAGT GACAGGTACC GCTGAACTTG GOACCACCAT TGAAGTTCGT

GCAACAGACG GAACAGTTTT AGGCACCGCA ACAACTGGAC CGACTGGCCA ATATACTGTG

ACGTTAGCTT CAGGAAAAGC AACAGCTAAA CAAACAGTGA ATGTAGTTGC TAAAAATGAT

ACTGCACTTG AGAGTCAACC AACTACAGCT ATGACACCCG CTGATGTTAC CACACCAACA

ATTGGTGACA TTACTGGAGA TTCAACAACT GGTTATGAAA TCACTGGGAC GGCGGACCCT

AATACCACCA TTGAACTACG GAACCCAGAT GGAACAATTA TTGGTACAAC GACAACGGAT

GATCAACGAA ACTTTACTGT GGACCTTCCA GCGGGAGCCG CTAATCCTGG TGATACATTA

ACAGTTGTTG GAAAAGACCG TGACGGCAAT GAAAGTCAAC CAACGGAAGT GACGGTCCCT

CAAGATGCAA CCGTACCAGC ACCAACTGTC ACGACTGTTA CAGGAA

EF069-4 (SEQ ID NO:264)

AGEA GANETLTAVA KNASGTEXTP TTFQTPADEA TVTAPTTTGV TGNSTAGYEV

KGTADANATV EIRNAGGTVI GTGTADGTGA FTVTVPAGEA GANETLTAVA KNASGTESTP

TTFQTPADEA TVTAPTITGV TGNSTAGYEV KGTADANATV EIRNAGGAVI GTGTADGTGA

FTVTIPAGEA GANETLTAVA KNASGTESTP TTFQTPADPN TPVATPIVET VTGSTTKGYE

VKGTAEVGTT IEVRDAAGTV LGTATTGTDG KYTVTLDSGT ATANQTLSVV AKNASGTESQ

PATATTPADV TAPTVDNITG NSGSGYETTG TADPNTTIEV RDPSGAVIGT GTSDANGDFT

VTLPTGTTNP GDTLTVIGKD NAGNESQPTE VLVPADATVT APTVTGVTGN SVAGYQVTGT

ADPNATIEIR DADGNVIATG TADGTGSFAV NLPAGTANAN ETLTALAKDP AGNTSTPTTF

QTPADEVVAP PSVDKVTGNT TQGYQVTGTA ELGTTIEVRA TDCTVLGTAT TGPTGQYTVT

LASGKATAKQ TVNVVAKNDT GLESQPTTAM TPADVTTPTI GDITGDSTTG YEITCTADPN

TTIEVRNPDG TIIGTTTTDD QGNFTVDLPA GAANPGDTLT VVGKDGDGNE SQPTEVTVPE

DAT VAAPTVT TVTGT

EF070-1 (SEQ ID NO:265)

TAGGGGAAGC TAATGATCTT GGTATTTATC GTTTATTTTA AAGAAAAGAG GGACGATCAG

ATGAAAAAGA AAATTGTTGA GGATTTTAAT CGGAAAAGTC AGCATAAAAA ATGGACAAAA

CGCAAGATCC TTAATTTAGC AATATCAAGT GGTTTATTAT TTACGTCATT AGCAATCCCT

GTAAGTATAG CTGTTACCTC TGGCACAATC AGTGCATCAG CAGCGGTCTT GGATATCGAA

CTATTATCAA ATGTTACGTC AAATAATGAC AGTGGCACTT CAACGAGTAA TCGTTGGACA

GCCGCAAACC AAAATCAACC AGTTAATTTC ACGGTTTCTG CTGGCGCTTT ACCAGATGCT

TCCGCTGTGT TTAGTGGACA AAAACAAGCG GTGTTAGTGG TTCCTCCTGA GTTAAGAGGA

AATGTAGCTG CAGCAGGCAG CGCAGCAATC AATACCAATG TCACGATTGA TCTTTCAAAA

GTTACTTTTT TGACTGCCGT TTTGAATGCA GCCAATGATT TAACCAATGT GATTACTCAA

ATTACCAGTG GGGCGTTAGG GAATTTAACT GGTGTTGATA TTGATTTGAC GGAAGTGAAT

CCTCAATTGG AATTAGTTAA TAACATTGAA AACTTAGGTG CTGCTTCATT TACAGCTCCG

GAAACGTTAG CAGCTGACGG CTCATACATT AGTGCACCGA TTAGTGATGG TTTAGGGTTA

GTTTTAGCCC AAAATGTTTC AAACATCTTA CAAGATTTGA ATGCGCCAGT TCAAGCTTTG

GAGGCAAAAG GTACCAGTAT CCCAAGTAAT CTTGTCGCCG CAGCTATAAA TGCAGCCTTG

CTTCCTGTCA AAGGCACGGT AAACGTGGCT GTTTCAGGTG CTTTGCCTTT ATTAGCGGTT

GGTGGTTCAG GCGTAAATGA GTTAGTGGAT GCTTCTTTAC TAGGCACAAC CACGGTTACT

TTACCAACTA CCGTTTCAAC ACCTCAAAAT TTATCCAATA ATTTAGATGC TCGTTTTGTA

GGAACAGTCG TTCAAACAGA TCTTTTAGAC GTTAATTTAT TAGCAACAGC AGACGGTGTA

TCCAACATTT ATTTTGCTGC AGGCACTACT ACTGAAGTAA CCGCACCAAC AATCACAGGA

GTAACAGGTA ATTCAACAGC AGGTTACGAA GTTAAAGGAA CTGCCGATCC CAATGCCACG

GTTGAAATCC GAAATCCAGG AGGCACCGTA ATAGGCACAG GTACCGCTGA TGGGACAGGA

GCGTTTACAG TTACCGTTCC CGCAGGTGAA CCAGGCGCCA ATGAAACGTT AACCGCCGTA

GCGAAAAACG CCAGCGGNAC AGAAAGNACG CCAACAACGT TCCAAACNCC AGCGGATGAA

GCAACCGTAA CCGCACCAAC AATCACAGGA GTGACAGGTA ATTCAACGGC AGGTTACGAA

GTTAAAGGAA CTGCCGATGC CAATGCCACG GTTGAAATCC GAAATGCAGG AGGCACCGTA

ATAGGCACAG GTACCGCTGA TGGGACAGGA GCGTTTACAG TTACCGTTCC CGCAGGTGAA

GCAGGTGCCA ATGAAACGTT AACCGCCGTA GCGAAAAACG CCAGCGGCAC AGAAAGTACG

CCAACAACGT TCCAAACACC AGCGGATGAA GCAACCGTAA CCGCACCAAC AATCACAGGA

GTGACAGGTA ATTCAACAGC AGGTTACGAA GTTAAAGGAA CTGCCGATGC CAATGCCACG

GTTGAGATCC GAAATGCAGG AGGTGCCGTG ATAGGTACAG GTACTGCTGA TGGGACAGGG

GCATTTACAG TTACCATTCC CGCAGGTGAA GCAGGTGCGA ATGAAACGTT AACCGCCCTA

GCGAAAAACG CCAGCGGTAC AGAAAGTACG CCAACAACGT TCCAAACGCC AGCGGATCCT

AATACGCCCG TGGCCACGCC AATTGTTGAG ACTGTAACAG GTAGTACAAC AAAAGGCTAT

GAGGTCAAAG GGACTGCTGA AGTTGGCACC ACCATTGAGG TTCGCGATGC AGCTGGCACG

GTCCTTGGTA CTGCAACAAC TGGAACTGAC GGAAAATATA CAGTGACTTT AGATTCAGGA

ACAGCAACAG CAAATCAAAC GCTGAGCGTT GTAGCGAAAA ACGCTAGTGG CACGGAAAGT

CAACCAGCAA CGGCGACAAC ACCAGCTGAT GTCACTGCAC CAACAGTTGA TAACATCACA

GGCAACTCTG GTTCGGGTTA TGAAATTACA GGAACAGCAG ACCCTAACAC AACAATCGAA

GTTCGTGATC CATCTGGGGC AGTCATTGGT ACAGGTACCT CTGATGCGAA TGGTGATTTT

ACTGTAACGC TACCAACGGG AACGACCAAT CCTGGGGATA CGTTAACAGT GATTGGAAAG

GATAACGCGG GAAATGAAAG TCAACCGACT GAAGTCCTTG TTCCTGCTGA TGCCACGGTT

ACAGCACCAA CTGTAACAGG AGTAACAGGT AATTCACTTG CTGCTTATCA GGTGACAGGC

ACCGCTGATC CGAATGCTAC CATCGAAATT CGTCATGCAG ATGGGAACGT GATTGCAACA

GGGACTGCCG ATGGGACTGG TTCCTTTGCT GTGAACCTTC CAGCTGGGAC GGCAAATGCG

AATGAAACAT TGACAGCGTT AGCCAAAGAT CCTGCTGGCA ATACAAGTAC ACCGACAACC

TTCCAAACAC CAGCAGATGA AGTAGTGGCA CCGCCAAGTG TCGACAAAGT TACTGGGAAT

ACAACACAAG GATATCAAGT GACAGGTACC GCTGAACTTG GCACCACCAT TGAAGTTCGT

GCAACAGACG GAACACTTTT AGGCACCGCA ACAACTGGAC CGACTGGCCA ATATACTGTG

ACGTTAGCTT CAGGAAAAGC AACAGCTAAA CAAACAGTGA ATGTAGTTGC TAAAAATGAT

ACTGGACTTG AGAGTCAACC AACTACAGCT ATGACACCCG CTGATGTTAC CACACCAACA

ATTGGTGACA TTACTGGAGA TTCAACAACT GGTTATGAAA TCACTGGGAC GGCGGACCCT

AATACCACCA TTGAAGTACG GAACCCAGAT GGAACAATTA TTGGTACAAC GACAACGGAT

GATCAAGGAA ACTTTACTGT CGACCTTCCA GCGCGAGCCG CTAATCCTGG TGATACATTA

ACAGTTGTTG GAAAAGACGG TGACGGCAAT GAAAGTCAAC CAACGGAAGT GACGGTCCCT

GAAGATGCAA CCGTAGCAGC ACCAACTGTG ACGACTGTTA CAGGAACAAC TGCCACTGGG

TATCAAGTAA CCGGCACGGC AGAGCCAAAT GTCACCATTG ACATTCACAA TGAAGCAGGT

TTAGTTATTG CTACGGGAAC GACTGATGGT GCTCGCGCAT TTACAATCAC TCTTCCGACG

GGCACAGCAA CAGCTAACGA AGCCTTAACT GCCATTGCGA AAGATGCTGC TGGGAAAGAA

AGTAATCCGA CTGCTTTCAA AACACCTGCT GATCCAGATG CACCAGTCGC GACACCTACT

GTTGACAAAA TCACTGGTAG CACGACAAAC GGCTATCAAG TAGTAGGAGC AGCAGAAGTT

GGTACAACAG TTGAGGTGCG TGACGCCGAT GGCACAGTCC TTGGCATGGC AACTACTGGA

ACTGATGGCA AATACACAGT GACTTTAGAG CCAGGCAAGG CCTCAGCTAA CGAAACAATA

ACTGTCGTAG CGAAAAATGC AACAGGAAAA GAAAGTCAGC CAGCTACAGC AACTACACCA

GTCGACTTAG CCACACCAAC CATTGATTCT ATTACCGGAA ATTCTAGTAA AGGTTACGAA

ATCACTGGAA CGGCGGAGCC AAAAACCACT ATTGATGTCC GTGACGCAGA CGGAACCATC

ATTGCTGCTA CAACTGCTAA CGAAACCGGC CAATATACGG TGACTCTACC AGCTGGCGTA

GTGACACCAG GAGAAACGAT TACGATTATT AGCAAAGATG GCGCAGGTAA TGAAAGTCAA

CCAGCTACAG CCGTTATTCC AGCGGATGTT GTTTTAGCGG CGCCAACTAT TACGAAGCTT

GAAGGAAACA AAGCCAATGG CTATACAGTC ACTGGAACTG CTGATCCAAA TGTCACGGTT

CAATTTTACA ATAGCAGTGA ACAATTATTG GCAAGTGGCA ATACAACTAC TGGAGGTACC

TTCTCCGTTC ATATTGCAGC AGGGTTAGCA ACAGAAAAAG AAACGTTAAC CGCACTAACC

ACAGATACAC AAGGAAATGT GAGTCCTAAA ACCACATTTA TGACGCCAGC CGATATTACG

GGAGAACCAG AGATTAAAAT TGCGGCACCA ACTGTTTCTT CAGTTTTAGG AACGTCTAAA

GCCGGCTACC TCATCAAAGG AACAGCTGAA CCAAACCGAA TCATTCAAAT TAGTAACCGA

CTATTAAGAA GTGTGATTGC TGTAGGTGCC ACCGATGCTG AAGGCAACTT CGCTATCCAA

TTAACAGCGG GACAAGCGAC TGCTCAACAA AGTTTACTTG CGACAGCTAC CGATGGCGCA

GGACATTACA GTACGGCTAC AACCTTCATG ACGCCAGCCG ACCCAACGAA TCCTGGAGGA

GGCAATGGTA ACACTGGCGG AAATAACGGC AATACAGGCG GCAATACAGG AAACAATGGC

GCAACTGGCG GGAATAATGG GAATGGTTCA AACACAGGTT CAAATCCAAA TGGAGGTTCT

GGTTTAGGCA CAACAGGTTC TGGCTTAGGT TCACTAGGCA ATGGCCTCGG TACAAATGGT

AGTGGCTACC ACCCTAAACT AAGTACCATC AGTTATGGCA CTGGAAATCA CGGGAAAACA

GGCTACTTAC CTAGCACAGG TGAAAAAGAG TCTTCAGCCG TGACAACAAG TTTGTTTGGC

GCCTTTGTCG CACTCCTTGC GAGCATGGGA ATCATCAAAC GCAAACGTAA AAACTAG

EF070-2 (SEQ ID NO:266)

M KKKIVEDFNR KSQHKKWTKR KMLNLAISSG LLFTSLAIPV

SIAVTSGTIS ASAAVLDIEL LSNVTSNNDS GTSTSNRWTA ANQNQPVNFT VSGGALADAS

AVFSGQKQAV LVVPPELRGN VAAAGSAAIN TNVTIDLSKV TFLTAVLNAA NDLTNVITQI

TSGALGNLTG VDIDLTEVNR QLELVNNIEN LGAASFTAPE TLAADGSYIS APISDGLGLV

LAQNVSNILQ DLNAAVQALE AKGTSIPSNL VAAAINAALL PVKGTVNVAV SGALPLLAVG

GSGVNELVDA SLLGTTTVTL PTTVSTPQNL SNNLDARFVG TVVQTDLLDV NLLATADGVS

NIYFAAGTTS EVTAPTITGV TGNSTAGYEV KGTADANATV EIRNAGGTVI GTGTADGTGA

FTVTVPAGEA GANETLTAVA KNASGTEXTP TTFQTPADEA TVTAPTITGV TGNSTAGYEV

KGTADANATV EIRNAGGTVI GTGTADGTGA FTVTVPAGEA GANETLTAVA KNASGTESTP

TTFQTPADEA TVTAPTITGV TGNSTAGYEV KGTADANATV EIRNAGGAVI GTGTADGTGA

FTVTIPAGEA GANETLTAVA KNASGTESTP TTFQTPADPN TPVATPIVET VTGSTTKGYE

VKGTAEVGTT IEVRDAAGTV LGTATTGTDG KYTVTLDSGT ATANQTLSVV AKNASGTESQ

PATATTPADV TAPTVDNITG NSGSGYEITG TADPNTTIEV RDPSGAVIGT GTSDANGDFT

VTLPTGTTNP GDTLTVTGKD NAGNESQPTE VLVPADATVT APTVTGVTGN SVAGYQVTGT

ADPNATIEIR DADGNVIATG TADGTGSFAV NLPAGTANAN ETLTALAKDP AGNTSTPTTF

QTPADEVVAP PSVDKVTGNT TQGYQVTGTA ELGTTIEVRA TDGTVLGTAT TGPTGQYTVT

LASGKATAKQ TVNVVAKNDT GLESQPTTAM TPADVTTPTI GDITGDSTTG YEITGTADPN

TTIEVRNPDG TIIGTTTTDD QGNFTVDLPA GAANPGDTLT VVGKDGDCNE SQPTEVTVPE

DATVAAPTVT TVTGTTATGY QVTGTAEPNV TIEIHNEAGL VIATGTTDGA GAFTITLPTG

TATANEALTA IAKDAAGKES NPTAFKTPAD PDAPVATPTV DKITGSTTNG YQVVGAAEVG

TTVEVRDADG TVLGMATTGT DGKYTVTLEP GKASANETIT VVAKNATGKE SQPATATTPV

DLATPTTDSI TCNSSKGYEI TGTAEPKTTI DVRDADGTII AATTANETGQ YTVTLPAGVV

TPGETITITS KDGAGNESQP ATAVIPADVV LAAPTITKVE GNKANGYTVT GTADPNVTVQ

FYNSSEQLLA SGNTTTGGTF SVHIAAGLAT EKETLTALTT DTQGNVSPKT TFMTPADTTG

EPEIKTAAPT VSSVLGTSKA GYLIKGTAEP NRIIQISNRL LRSVIAVGAT DAEGNFAIQL

TAGQATAQQS LLATATDGAG HYSTATTFMT PADPTNPGGG NGNTGGNNGN TGGNTGNNGA

TGGNNGNGSN TGSNPNGGSG LGTTGSGLGS LGNGLGTNGS GYHPKLSTIS YGTGNHGKTG

YLPSTGEKES SAVTTSLFGA FVALLASMGI IKRKRKN

EF070-3 (SEQ ID NO:267)

CGG TGACGGCAAT GAAAGTCAAC CAACGGAAGT GACGGTCCCT

GAAGATGCAA CCGTAGCAGC ACCAACTGTG ACGACTGTTA CAGGAACAAC TGCCACTGGG

TATCAACTAA CCGGCACGGC AGAGCCAAAT GTCACCATTG AGATTCACAA TGAAGCAGGT

TTAGTTATTG CTACGGGAAC GACTGATGGT GCTGGCGCAT TTACAATCAC TCTTCCGACC

GGCACAGCAA CAGCTAACGA AGCCTTAACT GCCATTGCGA AAGATGCTGC TGGGAAAGAA

AGTAATCCGA CTGCTTTCAA AACACCTGCT GATCCAGATG CACCAGTCGC GACACCTACT

GTTGACAAAA TCACTGGTAG CACGACAAAC GGCTATCAAG TAGTAGGAGC AGCAGAAGTT

GGTACAACAG TTGAGGTGCG TGACGCCGAT GGCACAGTCC TTGGCATGGC AACTACTGGA

ACTGATGGCA AATACACAGT GACTTTAGAG CCAGGGAAGG CCTCAGCTAA CGAAACAATA

ACTGTCGTAG CGAAAAATGC AACAGGAAAA GAAAGTCAGC CAGCTACAGC AACTACACCA

GTCGACTTAG CCACACCAAC CATTGATTCT ATTACCGGAA ATTCTAGTAA AGGTTACGAA

ATCACTGGAA CGGCGGAGCC AAAAACCACT ATTGATGTCC GTGACGCAGA CGGAACCATC

ATTGCTGCTA CAACTGCTAA CGAAACCGGC CAATATACGG TGACTCTACC AGCTGGCGTA

GTCACACCAG GAGAAACGAT TACGATTATT AGCAAAGATG GCGCAGGTAA TGAAAGTCAA

CCAGCTACAG CCGTTATTCC AGCGGATGTT GTTTTAGCGG CGCCAACTAT TACGAAGGTT

GAAGGAAACA AAGCCAATGG CTATACAGTC ACTGGAACTG CTGATCCAAA TGTCACGGTT

CAATTTTACA ATAGCAGTGA ACAATTATTG GCAAGTGGCA ATACAACTAC TGGAGGTACC

TTCTCCGTTC ATATTGCAGC AGGGTTAGCA ACAGAAAAAG AAACGTTAAC CGCACTAACC

ACAGATACAC AAGGAAATGT GAGTCCTAAA ACCACATTTA TGACGCCAGC CGATATTACG

GGAGAACCAG AGATTAAAAT TGCGGCACCA ACTGTTTCTT CAGTTTTAGG AACGTCTAAA

GCCGGCTACC TCATCAAAGG AACAGCTGAA CCAAACCGAA TCATTCAAAT TAGTAACCGA

CTATTAAGAA GTGTGATTGC TGTAGGTGCC ACCGATGCTG AAGGCAACTT CGCTATCCAA

TTAACAGCGG GACAAGCGAC TGCTCAACAA AGTTTACTTG CGACAGCTAC CGATGGCGCA

GGACATTACA GTACGGCTAC AACCTTCATG ACGCCAGCCG ACCCAACGAA TCCTGGAGGA

GGCAATGGTA ACACTGGCGG AAATAACGGC AATACAGCCG GCAATACAGG AAACAATGGC

GCAACTGGCG GGAATAATGG GAATGGTTCA AACACAGGTT CAAATCCAAA TGGAGGTTCT

GGTTTAGGCA CAACAGGTTC TGGCTTAGGT TCACTACGCA ATGGCCTCGG TACAAATGGT

ACTGGCTACC ACCCTAAACT AAGTACCATC AGTTATGGCA CTGGAAATCA CGGGAAAACA

GGCTACT

EF70-4 (SEQ ID NO:268)

DGDGNE SQPTEVTVPE

DATVAAPTVT TVTGTTATGY QVTGTAEPNV TIEIHNEAGL VIATGTTDGA GAFTITLPTG

TATANEALTA IAKDAAGKES NPTAFKTPAD PDAPVATPTV DKITGSTTNG YQVVGAAEVG

TTVEVRDADG TVLGMATTGT DGKYTVTLEP GKASANETIT VVAKNATGKE SQPATATTPV

DLATPTIDST TGNSSKGYEI TGTAEPKTTI DVRDADGTII AATTANETGQ YTVTLPAGVV

TPGETITIIS KDGAGNESQP ATAVIPADVV LAAPTITKVE GNKANGYTVT GTADPNVTVQ

FYNSSEQLLA SGNTTTGGTF SVHIAAGLAT EKETLTALTT DTQGNVSPKT TFMTPADITG

EPEIKIAAPT VSSVLGTSKA GYLIKGTAEP NRIIQISNRL LRSVIAVGAT DAEGNFAIQL

TAGQATAQQS LLATATDGAG HYSTATTFMT PADPTNPGGG NGNTGGNNGN TGGNTGNNGA

TGGNNGNGSN TGSNPNGGSG LGTTGSGLGS LGNGLGTNGS GYHPKLSTIS YGTGNHGKTG

YL

EF071-1 (SEQ ID NO:269)

TAAGTAGAAG TGGTCGGGAC AAACGTAGAA CTTTCGCTGA TTGCCGAAGA AATTACTTCT

GTCCCGCCAT TTATCTGCAG GTTTAAGCCG TGGAAGGGAA GTTATTTTGA CTTTCCTTTC

ATCGCTTTTT TAAGAAAGGA GCATGCTATG TTTAAAAAAT TAATGATTCA ACTTGCTTTA

GTGATTCGTT TAAGTTTAAC GATTCCGATG ACGGCTTNCG CTTACACCAT CGAAGCGGAT

CCAATCAACT TTACTTATTT TCCCGGCTCT GCAAGCAATG AATTAATTGT TTTACATGAA

TCTGGAAACG AGCGGAACCT AGGACCACAC AGTTTAGACA ATGAAGTGGC CTATATGAAA

CGAAATTGGT CAAATGCTTA TGTCTCATAT TTTGTCGGAT CTGGTGGACG AGTGAAACAA

TTAGCTCCTG CTGGCCAAAT TCAATATGGC GCAGGTTCTT TAGCTAATCA AAAAGCCTAT

GCGCAAATCG AATTGGCTCG AACGAATAAT GCGGCGACAT TTAAAAAAGA TTATGCTGCC

TATGTTAATT TGGCCCGTGA TTTGGCTCAG AACATTGGTG CTGATTTTTC TCTGGACGAT

GGAACAGGTT ATGGCATAGT CACTCATGAT TGGATTACAA AAAATTGGTG GGGAGATCAT

ACAGATCCTT ATCGTTATTT AGCGCGTGGG GGATTAGTAA AGCGCATTGG CACNAGATTT

ACAACGGGCG TTTCNGNAAC AGGTGAGACT GGTCATTATT CAGCCAGGTA A

EF071-2 (SEQ ID NO:270)

MF KKLMIQLALV

IGLSLTIPMT AXAYTIEADP INFTYFPGSA SNELIVLHES GNERNLGPHS LDNEVAYMKR

NWSNAYVSYF VGSGGRVKQL APAGQIQYGA GSLANQKAYA QIELARTNNA ATFKKDYAAY

VNLARDLAQN IGADFSLDDG TGYGIVTHDW ITKNWWGDHT DPYGYLARGG LVKRIGTRFT

TGVSXTGETG HYSAR

EF071-3 (SEQ ID NO:271)

C TTTAAAAAAT TAATGATTCA ACTTGCTTTA

GTGATTGGTT TAAGTTTAAC GATTCCGATG ACCGCTTNCG CTTACACCAT CGAAGCGGAT

CCAATCAACT TTACTTATTT TCCCGGCTCT GCAAGCAATG AATTAATTGT TTTACATGAA

TCTGGAAACG AGCGGAACCT AGGACCACAC AGTTTAGACA ATGAAGTGGC CTATATGAAA

CGAAATTGGT CAAATGCTTA TGTCTCATAT TTTGTCGGAT CTGGTGGACG AGTGAAACAA

TTAGCTCCTG CTGGCCAAAT TCAATATGGC GCAGGTTCTT TAGCTAATCA AAAAGCCTAT

GCGCAAATCG AATTGGCTCG AACGAATAAT GCGGCGACAT TTAAAAAAGA TTATGCTGCC

TATGTTAATT TGGCCCGTGA TTTGGCTCAG AACATTGGTG CTGATTTTTC TCTGGACGAT

GGAACAGGTT ATGGCATAGT CACTCATGAT TGGATTACAA AAAATTGGTG GGGAGATCAT

ACAGATCCTT ATGGTTATTT AGCGCGTGGG GGATTAGTAA AGCGCATTGG CACNAGATTT

ACAACGGGCG TTTCNGNAAC AGGTGACACT GGTCATTATT CAGCCAGGT

EF071-4 (SEQ ID NO:272)

F KKLMIQLALV

IGLSLTIPMT AXAYTIEADP INFTYFPGSA SNELIVLHES GNERNLGPHS LDNEVAYMKR

NWSNAYVSYF VGSGGRVKQL APAGQIQYCA GSLANQKAYA QIELARTNNA ATFKKDYAAY

VNLARDLAQN IGADFSLDDG TGYGIVTHDW ITKNWWGDHT DPYGYLARGG LVKRIGTRFT

TGVSXTGETG HYSAR

EF072-1 (SEQ ID NO:273)

TAATCAATGA AAAACGCACG TTGGTTAAGT ATTTGCGTCA TGCTACTCGC TCTTTTCGGG

TTTTCACAGC AAGCATTAGC AGAGGCATCG CAAGCAAGCG TTCAAGTTAC GTTGCACAAA

TTATTGTTCC CTGATGGTCA ATTACCAGAA CAGCAGCAAA ACACAGGGGA AGAGGGAACG

CTGCTTCAAA ATTATCGGGG CTTAAATGAC GTCACTTATC AAGTCTATGA TGTGACGGAT

CCGTTTTATC AGCTTCGTTC TGAAGGAAAA ACGGTCCAAG AGGCACAGCG TCAATTAGCA

GAAACCGGTG CAACAAATAG AAAACCGATC GCAGAAGATA AAACACAGAC AATAAATGGA

GAAGATGGAG TGGTTTCTTT TTCATTAGCT AGCAAAGATT CGCAGCAACG AGATAAAGCC

TATTTATTTG TTGAAGCGGA AGCACCAGAA GTGGTAAAGG AAAAAGCTAG CAACCTAGTA

GTGATTTTGC CTGTTCAAGA TCCACAAGGG CAATCGTTAA CCCATATTCA TTTATATCCA

AAAAATCAAG AAAATGCCTA TGACTTACCA CCACTTGAAA AAACGGTACT CGATAAGCAA

CAAGGCTTTA ATCAAGGAGA GCACATTAAC TATCAGTTAA CCACTCAGAT TCCAGCGAAT

ATTTTAGGAT ATCAGCAATT CCGTTTGTCA GATAAGGCGG ATACAACGTT GACACTTTTA

CCAGAATCAA TTGAGGTAAA AGTGGCTGGA AAAACAGTTA CTACAGGTTA CACACTGACG

ACGCAAAAGC ATGGATTTAC GCTTGATTTT TCAATTAAAG ACTTACAAAA CTTTGCAAAT

CAAACAATGA CTGTGTCGTA TCAAATGCGT TTAGAAAAGA CCGCTGAACC TGACACTGCG

ATTAACAACG AAGGACAATT AGTCACGGAC AAACATACCT TGACTAAAAG AGCCACAGTT

CGTACAGGCG GCAAGTCTTT TGTCAAAGTT GATAGTGAAA ATGCGAAAAT CACCTTGCCA

GAGGCTGTTT TTATCGTCAA AAATCAAGCG GGGGAATACC TCAATGAAAC AGCAAACGGG

TATCGTTGGC AAAAAGAAAA AGCATTAGCT AAAAAATTCA CGTCTAATCA AGCCGGTGAA

TTTTCAGTTA AAGGNNTTAA AAGATCGCCA GTACTTCTTG GAAGAAATCT CTCCACCAAA

AGGTTATCTT CTGAATCAAA CAGAAATTCC TTTTACGGTG GGAAAAAATT CTTATGCAAC

GAACGGACAA CGAACAGCAC CGTTACATGT AATCAATAA

EF072-2 (SEQ ID NO:274)

MKNARWLSI CVMLLALFGF SQQALAEASQ ASVQVTLHKL LFPDGQLPEQ QQNTGEEGTL

LQNYRGLNDV TYQVYDVTDP FYQLRSEGKT VQEAQRQLAE TGATNRKPIA EDKTQTINGE

DGVVSFSLAS KDSQQRDKAY LFVEAEAPEV VKEKASNLVV ILPVQDPQGQ SLTHIHLYPK

NEENAYDLPP LEKTVLDKQQ GFNQGEHINY QLTTQIPANI LGYQEFRLSD KADTTLTLLP

ESIEVKVAGK TVTTGYTLTT QKHGFTLDFS IKDLQNFANQ TMTVSYQMRL EKTAEPDTAI

NNEGQLVTDK HTLTKRATVR TGGKSFVKVD SENAKITLPE AVFIVKNQAG SYLNETANGY

RWQKEKALAK KFTSNQAGEF SVKGXKRWPV LLGRNLCTKR LSSESNRNSF YGGKKFLCNE

RTTNSTVTCN Q

EF072-3 (SEQ ID NO:275)

ATTACCAGAA CAGCAGCAAA ACACAGGGGA AGAGCGAACG

CTGCTTCAAA ATTATCGGGG CTTAAATGAC GTCACTTATC AAGTCTATGA TGTGACGGAT

CCGTTTTATC AGCTTCGTTC TGAAGGAAAA ACGGTCCAAG AGGCACAGCG TCAATTAGCA

GAAACCGGTG CAACAAATAG AAAACCGATC GCAGAAGATA AAACACAGAC AATAAATGGA

GAAGATGGAG TGGTTTCTTT TTCATTAGCT AGCAAAGATT CGCAGCAACG AGATAAAGCC

TATTTATTTG TTGAAGCGGA AGCACCAGAA GTGGTAAAGG AAAAAGCTAG CAACCTAGTA

GTGATTTTGC CTGTTCAAGA TCCACAAGGG CAATCGTTAA CGCATATTCA TTTATATCCA

AAAAATGAAG AAAATGCCTA TGACTTACCA CCACTTGAAA AAACGGTACT CGATAAGCAA

CAAGGCTTTA ATCAAGGAGA GCACATTAAC TATCAGTTAA CGACTCAGAT TCCAGCGAAT

ATTTTAGGAT ATCAGGAATT CCGTTTGTCA GATAAGGCGG ATACAACGTT GACACTTTTA

CCAGAATCAA TTGAGGTAAA AGTGGCTGGA AAAACAGTTA CTACAGGTTA CACACTGACG

ACGCAAAAGC ATGGATTTAC GCTTGATTTT TCAATTAAAG ACTTACAAAA CTTTGCAAAT

CAAACAATGA CTGTGTCGTA TCAAATGCGT TTAGAAAAGA CCGCTGAACC TGACACTGCG

ATTAACAACG AAGGACAATT AGTCACGGAC AAACATACCT TGACTAAAAG AGCCACAGTT

CGTACAGGCG GCAAGTCTTT TGTCAAAGTT GATAGTGAAA ATGCGAAAAT CACCTTGCCA

GAGGCTCTTT TTATCGTCAA AAATCAAGCG GGGGAATACC TCAATGAAAC AGCAAACGGG

TATCGTTGGC AAAAAGAAAA AGCATTAGCT AAAAAATTCA CGTCTAATCA AGCCGGTGAA

TTTTCAGTTA AAGGNNTTAA AAGATGGCCA GTACTTCTTG GAAGAAATCT CTGCACCAAA

AGGTTATCTT CTGAATCAAA CAGAAATTCC TTTTACGGTG GGAAAAAATT CTTATGCAAC

GAACGGACAA CGAACAGCAC CGTTACATGT A

EF072-4 (SEQ ID NO:276)

QLPEQ QQNTGEEGTL

LQNYRGLNDV TYQVYDVTDP FYQLRSEGKT VQEAQRQLAE TGATNRKPIA EDKTQTINGE

DGVVSFSLAS KDSQQRDKAY LFVEAEAPEV VKEKASNLVV ILPVQDPQGQ SLTHIHLYPK

NEENAYDLPP LEKTVLDKQQ GFNQGEHINY QLTTQIPANT LGYQEFRLSD KADTTLTLLP

ESIEVKVAGK TVTTGYTLTT QKHGFTLDFS IKDLQNFANQ TMTVSYQMRL EKTAEPDTAI

NNEGQLVTDK HTLTKRATVR TGGKSFVKVD SENAKITLPE AVFIVKNQAG EYLNETANGY

RWQKEKALAK KFTSNQAGEF SVKGXKRWPV LLGRNLCTKR LSSESNRNSF YGGKKFLCNE

RTTNSTVTC

EF073-1 (SEQ ID NO:277)

TAAATGAACA AATTAAATAC AAAATTACTG ATTGGCTATA TTCTTTTAGG AGCCTTAATC

ATTGCTGTCG CTAGAGAATA TGGCTTCTTC GCTTTTGTGA TTCTGGTAGG CTTTTTAGTA

TTCGTTCTCT ATCGAAAAAA GAAAAATGCC GCCGACAAAA GCGATCAAAT GCCTTACTTA

ACGAAAGATA AAGAAGCCCA TTATCGTGAG TTGGGGTTAT CTCCACAAGA AATTGATTTT

TTCAGAAGTA CAATGAGCAC ACCCAAAAAA CAAATCATAC AATTGCAAGA AAACATGAAT

CGTTCAACTA AATTACGGGC GATTGACTTA CGTAATGATA CTACGAAGGT TTCTAAAGCT

CTGTTTAAAG AGTTAGTGAA AGAACCTAAA AAGTTACACT TAGCCAATCA CTTTCTCTAT

ACACATTTAC CAAATATCGT TGACTTAACA AGTAAACATT TAGAAATCGA ACAACACGAA

GTAAAAAACA AACAAACGTA TGAAAAATTA GAAGAAAGCG CACAAATCAT TGACCAATTG

TCAAAATTAG TTAAAAATGA TTATGAGGAA ATCGTTTCCG ATGACTTAGA CGATTTAGAT

GTCGAAATGT CGATCGCTAA AAGCAGCTTG TCGCAAAAAG CTGCAACTGA GCAATCACCT

CAAGTAAACG AAGACCAGCA ATAA

EF073-2 (SEQ ID NO:278)

MNKLNTKLLI GYILLOALTI AVAREYGFFA FVILVGFLVF VLYRKKKNAA DKSDQMPYLT

KDKEAHYREL GLSPQEIDFF RSTMSTAKKQ IIQLQENHNR STKLRAIDLR NDTTKVSKAL

FKELVKEPKK LHLANHFLYT HLPNIVDLTS KHLEIEQHEV KNKQTYEKLE ESAQIIDQLS

KLVKNDYEEI VSDDLDDLDV EMSIAKSSLS QKAATEESPQ VNEDQQ

EF073-3 (SEQ ID NO:279)

CT ATCGAAAAAA GAAAAATGCC GCCGACAAAA GCGATCAAAT GCCTTACTTA

ACGAAAGATA AAGAAGCCCA TTATCGTGAG TTGGGGTTAT CTCCACAAGA AATTGATTTT

TTCAGAAGTA CAATGAGCAC AGCCAAAAAA CAAATCATAC AATTGCAAGA AAACATGAAT

CGTTCAACTA AATTACGGGC GATTGACTTA CGTAATGATA CTACGAAGGT TTCTAAAGCT

CTGTTTAAAG AGTTAGTGAA AGAACCTAAA AAGTTACACT TAGCCAATCA CTTTCTCTAT

ACACATTTAC CAAATATCGT TGACTTAACA AGTAAACATT TAGAAATCGA ACAACACGAA

GTAAAAAACA AACAAACGTA TGAAAAATTA GAAGAAAGCG CACAAATCAT TGACCAATTG

TCAAAATTAG TTAAAAATGA TTATGAGGAA ATCGTTTCCG ATGACTTAGA CGATTTAGAT

GTCGAAATGT CGATCGCTAA AAGCAGCTTG TCGCAAAAAG CTGCAACTGA GGAATCACCT

CAAGTAAACG AAGACCAGCA AT

EF073-4 (SEQ ID NO:280)

YRKKKNAA DKSDQMPYLT

KUKEAHYREL GLSPQEIDFF RSTMSTAKKQ IIQLQENMNR STKLRAIDLR NDTTKVSKAL

FKELVKEPKK LHLANHFLYT HLPNIVDLTS KHLEIEQHEV KNKQTYEKLE ESAQIIDQLS

KLVKNDYEEI VSDDLDDLDV EMSIAKSSLS QKAATEESPQ VNEDQQ

EF074-1 (SEQ ID NO:281)

TAAAGGAGTT CTCAAAAAAT GAAGCTAAAA AAAATAATTC CTGCTTTTCC CCTTCTTTCA

ACCGTTGCAG TTGGCTTGTG GTTAACGCCT ACTCAAGCTT CTGCAGATGC TGCGGATACG

ATGGTAGATA TCTCTGGCAA AAAAGTGTTG GTTGGATATT GGCATAACTG GGCCTCAAAA

GGACGCGATG GTTACAAACA AGGAACATCA GCATCACTAA ACCTTTCAGA AGTAAATCAA

GCCTACAATG TCGTACCGGT TTCCTTCATG AAAAGCGATG GCACGACACG GATTCCTACG

TTCAAGCCTT ATAACCAAAC GGACACTGCC TTCCGACAAG AAGTCGCACA ATTAAATAGT

CAAGGTCGCG CAGTTTTATT GGCACTTGGT GGAGCAGATG CACATATTCA ATTAGTCAAA

GGCGATGAAC AAGCCTTTGC GAATGAAATC ATTCGTCAAG TGGAAACATA CGGCTTTGAT

GGTTTAGACA TCGACTTACA GCAATTGGCG ATTACTGCTG GCGACAACCA AACCGTCATC

CCTGCTACGT TGAAAATAGT CAAAGACCAT TATCGAGCAC AAGGAAAAAA TTTCATCATT

ACGATGGCAC CAGAATTCCC TTATTTAAAA CCTGGTGCCG CTTATGAAAC ATACATTACT

TCCCTAAATG GTTATTATGA TTACATTGCC CCACAATTAT ATAACCAAGG CGGCGACGGT

GTCTGGGTTG ATGAAGTTAT GACTTGGGTT GCTCAAAGCA ACGATGCTCT AAAATACGAG

TTCCTCTATN ATATT

EF074-2 (SEQ ID NO:282)

MKLKK IIPAFPLLST VAVGLWLTPT QASADAADTM VDISGKKVLV GYWHNWASKG

RDGYKQGTSA SLNLSEVNQA YNVVPVSFMK SDGTTRIPTF KPYNQTDTAF RQEVAQLNSQ

GRAVLLALGG ADAHIQLVKG DEQAFANEII RQVETYGFDG LDIDLEQLAI TAGDNQTVIP

ATLKIVKDHY FAQGKNFIIT MAPEFPYLKP GAAYETYITS LNGYYDYIAP QLYNQGGDGV

WVDEVMTWVA QSNDALKYEF LYXI

EF074-3 (SEQ ID NO:283)

TGC TGCGGATACG

ATGGTAGATA TCTCTGGCAA AAAAGTGTTG GTTGGATATT GCCATAACTG GGCCTCAAAA

GGACGCGATG GTTACAAACA AGGAACATCA GCATCACTAA ACCTTTCAGA AGTAAATCAA

GCCTACAATG TCGTACCGCT TTCCTTCATG AAAAGCGATG GCACGACACG GATTCCTACG

TTCAAGCCTT ATAACCAAAC GCACACTGCC TTCCGACAAG AAGTCGCACA ATTAAATAGT

CAAGGTCGCG CAGTTTTATT GGCACTTGGT GGAGCAGATG CACATATTCA ATTAGTCAAA

GGCGATGAAC AAGCCTTTGC GAATGAAATC ATTCGTCAAG TGGAAACATA CGGCTTTGAT

GGTTTAGACA TCGACTTAGA GCAATTGGCG ATTACTGCTG GCGACAACCA AACCGTCATC

CCTGCTACGT TGAAAATAGT CAAAGACCAT TATCGAGCAC AAGGAAAAAA TTTCATCATT

ACGATGGCAC CAGAATTCCC TTATTTAAAA CCTGGTGCCG CTTATGAAAC ATACATTACT

TCCCTAAATG GTTATTATCA TTACATTGCC CCACAATTAT ATAACCAAGG CGGCGACGGT

GTCTGGGTTG ATGAAGTTAT GACTTGGGTT GCTCAAAGCA ACGATGCTCT AAAATACGAG

TTCCTCT

EF074-4 (SEQ ID NO:284)

AADTM VDISGKKVLV CYWHNWASKG

RDGYKQGTSA SLNLSEVNQA YNVVPVSFMK SDGTTRIPTF KPYNQTDTAF RQEVAQLNSQ

GRAVLLALGG ADAHIQLVKG DEQAFANEIT RQVETYGFDG LDIDLEQLAI TAGDNQTVIP

ATLKIVKDHY RAQGKNFIIT MAPEFPYLKP GAAYETYITS LNGYYDYIAP QLYNQGGDGV

WVDEVMTWVA QSNDALKYEF LY

EF075-1 (SEQ ID NO:285)

TAACCTATAA GAAAAAAATC ACAACCTGTG ATAAATTATT GGAGGNAAAA TATGTCAAAA

GGGAAGAAAA TTTTTGCCAT TATCNTTGGA ATTATCTTGG NTCTATTTCT TGCAGTTCTT

GGAATGGGAG CAAAACTTTA TTGGGATGTT TCTAAATCAA TGGATAAAAC CTATGAAACA

GTAGAACGAT CTAAAAAAAG TCAGGTCAAT TTAAACAATA AGGAGCCTTT TTCTGTTTTA

TTATTAGGGA TTGATACAGG CGATGATGGG CGTGTCGAGC AAGGTCGTTC GGATACAACA

ATTGTTGCAA CAGTTAATCC TCGTGACAAG CAAACAACCT TAGTCAGTCT TGCTCGCGAT

ACCTATGTTG ATATTCCAGG TCAAGGAAAA CAAGATAAAT TGAATCACGC CTATGCTTTT

GGTGGCGCAT CTTTACCAAT GGACACAGTT GAAAACTATT TAAACATACC TATTAATCAT

TATGTTTCAA TTAATATGGC TGGTTTAAAA GAATTAGTCA ACGCGGTTCC CGGAATCGAA

GTGAACAATA ATCTGACTTT TTCTCAAGAC GGATATGATT TTACGATTGG TAAAATTTCA

TTCGATGGTG AACAAGCACT CTCCTATTCA AGAATGCGTT ACGAAGACCC TAATGGTGAC

TACGGCCGCC AAGAACGTCA AAGAAAAGTG ATTGAAGCCA TCGTCCAAAA AGTCTTAAGT

CTTAACAGCG TAAGCAACTA TCAAGAAATT TTAACAGCTG TTTCTGATAA TATGAAGACA

GATTTAAGTT TTGATGACAT GAAAAAAATT GCCTTAGATT ATCGCAGTGC CTTTGGTAAA

GTGAAACAAG ACCAACTTCA AGGTACTGGT TTTATGCAAG ATGCTGTTTC CTATCAACGT

GTGGATGAAC AAGAATTAAC TCGTGTCCAA CAAGAGTTGA AAAATCAATT GAATACAAAA

TAA

EF075-2 (SEQ ID NO:286)

MSKG KKIEFAIIXGI ILXLJFLAVVG MGAKLYWIJVS KSMDKTYETV

ERSKKSQVNL NNKEPFSVLL LGIDTGDDGR VEQGRSDTTI VATVNPRDKQ TTLVSLARDT

YVDIPGQGKQ DKLNHAYAFG GASLANDTVE NYLNIPINHY VSINMAGLKE LVNAVGGIEV

NNNLTFSQDG YDFTICKISL DGEQALSYSR MRYEDPNGDY GRQERQRKVT EGTVQKVLSL

NSVSNYQEIL TAVSDNMKTD LSFDDMKKTA LDYRSAFGKV KQDQLQCTGF MQDCVSYQRV

DEQELTRVQQ ELKNQLNTK

EF075-3 (SEQ ID NO:287)

ACTTTA TTGGGATGTT TCTAAATCAA TGCATAAAAC CTATGAAACA

GTAGAACGAT CTAAAAAAAG TCAGGTCAAT TTAAACAATA AGGAGCCTTT TTCTGTTTTA

TTATTAGGGA TTGATACAGG CGATGATGGG CGTGTCGAGC AAGGTCGTTC GGATACAACA

ATTGTTGCAA CAGTTAATCC TCGTGACAAG CAAACAACCT TAGTCAGTCT TGCTCGCGAT

ACCTATGTTG ATATTCCAGG TCAAGGAAAA CAACATAAAT TGAATCACGC CTATGCTTTT

GGTCGCGCAT CTTTAGCAAT GGACACAGTT GAAAACTATT TAAACATACC TATTAATCAT

TATGTTTCAA TTAATATGGC TGGTTTAAAA GAATTAGTCA ACGCGGTTGG CGGAATCGAA

GTGAACAATA ATCTGACTTT TTCTCAAGAC GGATATGATT TTACGATTGG TAAAATTTCA

TTGGATGCTG AACAAGCACT CTCCTATTCA AGAATGCGTT ACGAAGACCC TAATGGTGAC

TACGCCCGCC AAGAACGTCA AAGAAAAGTG ATTCAAGGCA TCGTCCAAAA ACTCTTAAGT

CTTAACAGCG TAAGCAACTA TCAAGAAATT TTAACAGCTG TTTCTGATAA TATGAAGACA

GATTTAAGTT TTGATGACAT GAAAAAAATT CCCTTAGATT ATCGCACTGC CTTTGGTAAA

GTGAAACAAG ACCAACTTCA AGGTACTGGT TTTATGCAAG ATGGTGTTTC CTATCAACGT

GTGGATGAAC AAGAATTAAC TCGTGTCCAA CAAGAGTTGA AAAATCAATT GAATACAAAA

EF075-4 (SEQ ID NO:288)

KLYWDVS KSMDKTYETV

ERSKKSQVNL NNKEPFSVLL LGIDTGDDGR VEQGRSDTTI VATVNPEDKQ TTLVSLARDT

YVDIPCQGKQ DKLNHAYAFG GASLANDTVE NYLNIPINHY VSINNAGLKE LVNAVGGIEV

NNNLTFSQDG YDFTIGKTSL DGEQALSYSR MRYEDPNGDY GRQERQRKVI EGIVQKVLSL

NSVSNYQEIL TAVSDNNKTD LSEDDMKKIA LDYRSAFGKV KQDQLQGTGF MQDGVSYQRV

DEQELTRVQQ ELKNQLNTK

EF076-1 (SEQ ID NO:289)

TAGAAAATAA CAGAGGAGCT GAAGGAAATG AAACCATCAA CAAAAATTCG TATCGGTTTA

AGCATTGCTG CAGTTGCAAG TGTCTCTGTT GCAGTCATCG CTTCTGAAAA AATTATTAAG

AAGGTATCTC ATGTTTCCAA TCGTTATAAA GTTAAAAAGT TTGTAGACGA TAAATTTGAT

CGAAACCAAA AATTATTATC GATTGTCGAT GATTTATCCG ATGATGAATT ACATTCTGTT

TTAAATGTTG TGGATCGTGT GAAAGATGGC GGTTCAAAAT TAGCTGAATA TGGCGAAAAA

GTTAAAGACA ATACAGATTC TTTAAAAGAA CGCTTTTTCA CATTTATTGA AGATGCAATG

AACTTAAAAA AGTCGCCTAG GCCATCTTTT TTTTATAAAA ATAATTCTTT TGTTTCAACA

TAA

EF076-2 (SEQ ID NO:290)

MK ASTKIGIGLS IAAVASVSVA VIASEKIIKK VSHVSNRYKV KKFVDDKFDG

NQKLLSIVDD LSDDELDSVL NVVDRVKDCG SKLAEYGEKV KDNTDSLKER FFTFIEDAMK

LKKWPRPSFF YKNNSFVST

EF076-3 (SEQ D NO:291)

CATCG CTTCTGAAAA AATTATTAAG

AAGGTATCTC ATGTTTCCAA TCGTTATAAA GTTAAAAAGT TTGTAGACGA TAAATTTGAT

GGAAACCAAA AATTATTATC GATTGTCGAT GATTTATCCG ATGATGAATT AGATTCTGTT

TTAAATGTTG TGGATCGTGT GAAAGATGGC GCTTCAAAAT TAGCTGAATA TGGCGAAAAA

GTTAAAGACA ATACACATTC TTTAAAAGAA CGCTTTTTCA CATTTATTGA AGATGCAATG

AAGTTAAAAA AGTGGCCTAG GCCATCTTTT TTTTATAAAA ATAATTCTT

EF076-4 (SEQ ID NO:292)

VIASEKIIKK VSHVSNRYKV KKFVDDKFDG

NQKLLSIVDD LSDDELDSVL NVVDRVKDGG SKLAEYGEKV KDNTDSLKER FFTFIEDAMK

LKKWPRPSFF YKNNS

EF077-1 (SEQ ID NO:293)

TAATGTAAAG TGAATGATCG GAGAGAAAAA GAGATGAAGC ATGTAACAAA ATTGGGGATT

ACAATTATAA CAGGAGTTTT GOCATTATTA TTTGAATTTA TTTTACATCA GCCGAATTGG

GCGTATGGCA TTATTTTAAT AACAGGTTCT GTAATGGCGT TAATGATGTT CTCGGAAATG

ATTCAAACCT TACGTGAAGG AAAATATGGT GTCGATATTT TAGCGATTAC CGCTATCGTT

GCAACCTTAG CTGTGGGAGA ATACTGGGCC AGTTTGATGA TTTTAATTAT GTTGACTGGT

GGTGATTCAT TAGAAGACTA TGCCGCTGGA AAAGCTAACC AAGAGCTGAA GTCATTATTG

GATAACTCGC CACAAAAAGC TCATCGCTTG AATGGCGAAA ATTTAGAAGA TGTTTCTGTT

GAGGAAATCA ATGTTGGCGA TGAATTAGTA GTAAAACCAG GGGAACTAGT TCCAGTTGAT

GGCTTGGTAA AAACCGGGAC ATCAACAGTC GATGAATCTT CATTAACAGG AGAATCAAAA

CCAATTGAAA AAAATCCTGG GGATGAATTA ATGTCGGGTT CCGTGAATGG TGACGGCTCT

TTGAAAATGG TTGCTGAAAA AACTGTAGCA GACAGTCAAT ATCAAACAAT TGTGAACTTA

GTGAAAGAAT CTGCGGCGCG TCCAGCTCAT TTTGTACGTT TAGCAGATCG CTATGCGGTA

CCTTTTACAC TAGTTGCCTA CCTAATTGCA GGTGTTGCTT GGTTTGTTTC AAAAAGTCCG

ACACGTTTTG CGGAAGTCTT AGTTGTTGCT TCGCCGTGTC CTTTAATTCT ATCTGCCCCA

ATTGCTTTAG TGGCAGGGAT GGGTCGTTCA AGTCGTCATG GCGTCGTTAT TAAATCGGGA

ACGATGGTCG AAAAATTAGC TTCTGCAAAA ACGATTGCGT TTGATAAAAC AGGCACGATT

ACGCAAGGAC AACTTTCTGT TGATCAAGTC CAACCAATCA ATGCTGGAAT AACTGCTGCT

GAATTAGTGG GATTGGCAGC AAGCGTGGAA CAAGAATCAA GTCATATTTT AGCTAGATCA

ATTGTTGCTT ATGCCAGAAA GCAAGATGTC CCATTAAAAA ATATTACAGA TCTAGCCGAA

GTTTCTGGTG CTGGCGTGAA GGCATTTGTG GATGGTGCTG AGATACGGGT AGGTAAAAAG

AATTTTGTGA CACAAGAGTC TCAAGAAACT GAAAAAATTG ATAAAACGAC TATTCATATT

TCACGTAATG GCACATATTT AGGCCGAATT ACTTTTACAG ACACTGTACG CCCAGAAGCA

AAAGAGACTA TGGAAAAATT ACACCAATTA CATCTTCAAC GAATTTTAAT GCTGACGGGG

GATCAAGAAT CCGTTGCAGA AACGATTGCT GCAGAAGTAG GAATTACCGA AGTACATGGG

GAATGTTTAC CACAAGATAA ATTAACTATT CTAAAAGAAT TGCCTAAAGA AAATCATCCA

GTCATCATGG TAGGAGATGG TGTAAATGAT GCACCTTCGC TTCCTGCTGC AGACGTAGGT

ATTGCTATGG GTGCTCATGG AGCTACTGCG GCTAGTGAAA CTGCTGACGT TGTTATTTTA

AAAGATGACT TAAGTAAAGT CAGCCAAGCG GTCGAAATTG CCCAAGATAC CATGAAAATT

GCCAAACAAT CTGTATTAAT CGGAATTTTT ATCTGCGTTT TACTAATGTT AATTGCTAGT

ACCGGGATCA TTCCGGCGCT AATCGGGGCT ATGCTACAAG AAGTCGTGGA CACTGTGTCA

ATCTTATCTG CTTTGCGTGC TCGTCGAATT GGCCAGTAA

EF077-2 (SEQ ID NO:294)

MKHVThLGIT IITGVLALLF EFILHQPNWA YGIILITGSV MALMNFWEMI

QTLREGKYGV DILAITAIVA TLAVGEYWAS LMILIMLTGG DSLEDYAAGK ANQELKSLLD

NSPQKAHRLN GENLEDVSVE EINVGDELVV KPGELVPVDG LVKTGTSTVD ESSLTGESKP

IEKNPGDELM SGSVNGDGSL KMVAEKTVAD SQYQTIVNLV KESAARPAHF VRLADRYAVP

FTLVAYLIAG VAWFVSKSPT RFAEVLWAS PCPLILLSAPI ALVAGMGRSS RHGVVIKSGT

MVEKLASAKT IAFDKTGTIT QGQLSVDQVQ PINAGITAAE LVGLAASVEQ ESSHILARSI

VAYARKQDVP LKNITDLAEV SGAGVKAFVD CAEIRVGKKN FVTQESQETE KIDKTTIHIS

RNGTYLGRIT FTDTVRPEAK ETMEKLHQLH LQRILMLTGD QESVAETIAA EVGITEVHGE

CLPQDKLTIL KELPKENHPV IMVGDGVNDA PSLAAADVGI AMGAHGATAA SETADVVILK

DDLSKVSQAV ETAQDTMKIA KQSVLIGIFI CVLLMLIAST GIIPALIGAN LQEVVDTVSI

LSALRARRTG Q

EF077-3 (SEQ ID NO:295)

TCA GCCGAATTGG

GCGTATGGCA TTATTTTAAT AACAGGTTCT GTAATGGCGT TAATGATGTT CTGGGAAATG

ATTCAAACCT TACGTGAAGG AAAATATGGT GTCGATATTT TAGCGATTAC CGCTATCGTT

GCAACCTTAG CTGTGGGAGA ATACTGGGCC AGTTTGATGA TTTTAATTAT GTTGACTGGT

GGTGATTCAT TAGAAGACTA TGCCGCTGGA AAAGCTAACC AAGAGCTGAA GTCATTATTG

GATAACTCGC CACAAAAAGC TCATCGCTTG AATGGCGAAA ATTTAGAAGA TGTTTCTGTT

GAGGAAATCA ATGTTGGCGA TGAATTAGTA GTAAAACCAG GGGAACTAGT TCCAGTTGAT

GGCTTGGTAA AAACCGGGAC ATCAACAGTC GATGAATCTT CATTAACAGG AGAATCAAAA

CCAATTGAAA AAAATCCTGG GGATGAATTA ATGTCGGGTT CCGTGAATGG TGACGGCTCT

TTGAAAATGG TTGCTGAAAA AACTGTAGCA GACAGTCAAT ATCAAACAAT TGTGAACTTA

GTGAAAGAAT CTGCGGCGCG TCCAGCTCAT TTTGTACGTT TAGCAGATCG CTATGCGGTA

CCTTTTACAC TAGTTGCCTA CCTAATTGCA GGTGTTGCTT GGTTTGTTTC AAAAAGTCCG

ACACGTTTTG CGGAAGTCTT AGTTGTTGCT TCGCCGTGTC CTTTAATTCT ATCTGCCCCA

ATTGCTTTAG TGGCAGGGAT GGGTCGTTCA AGTCGTCATG GGGTCGTTAT TAAATCGGGA

ACGATGGTCG AAAAATTAGC TTCTGCAAAA ACGATTGCGT TTGATAAAAC AGGCACGATT

ACGCAAGGAC AACTTTCTGT TGATCAAGTC CAACCAATCA ATGCTGGAAT AACTGCTGCT

GAATTAGTGG GATTGGCAGC AAGCGTGGAA CAAGAATCAA CTCATATTTT AGCTAGATCA

ATTGTTGCTT ATGCCAGAAA GCAAGATGTC CCATTAAAAA ATATTACAGA TCTAGCGGAA

GTTTCTGGTG CTGGCGTGAA GGCATTTGTG GATGGTGCTG AGATACGGGT AGGTAAAAAG

AATTTTGTGA CACAAGAGTC TCAAGAAACT GAAAAAATTG ATAAAACGAC TATTCATATT

TCACGTAATG GCACATATTT AGGCCGAATT ACTTTTACAG ACACTGTACG CCCAGAAGCA

AAAGAGACTA TGGAAAAATT ACACCAATTA CATCTTCAAC GAATTTTAAT GCTGACGGGG

GATCAAGAAT CCGTTGCAGA AACGATTGCT GCAGAAGTAG GAATTACCGA AGTACATGGG

GAATGTTTAC CACAAGATAA ATTAACTATT CTAAAAGAAT TGCCTAAAGA AAATCATCCA

GTCATCATGG TAGGAGATOG TGTAAATGAT GCACCTTCGC TTGCTGCTGC AGACGTAGGT

ATTGCTATGG GTGCTCATGG AGCTACTGCG GCTAGTGAAA CTGCTGACGT TGTTATTTTA

AAAGATGACT TAAGTAAAGT CAGCCAAGCG GTCGAAATTG CCCAAGATAC CATGAAAATT

GCCAAACAAT CTGTATTAAT CGGAATTTTT ATCTGCGTTT TACTAATGTT AATTGCTAGT

ACCGGGATCA TTCCGGCGCT AATCGGGGCT ATGCTACAAG AAGTCGTGGA CACTGTGTCA

ATCTTATCTG CTTTGCGTGC TCGTCGAATT GGCC

EF077-4 (SEQ ID NO:296)

QPNWA YGITLITGSV MALMMFWEMI

QTLREGKYGV DILAITAIVA TLAVGEYWAS LMILIMLTGG DSLEDYAAGK ANQELKSLLD

NSPQKAHRLN GENLEDVSVE ETNVGDELVV KPGELVPVDG LVKTGTSTVD ESSLTGESKP

IEKNPGDELM SGSVNGDGSL KNVAEKTVAD SQYQTIVNLV KESAARPAHF VRLADRYAVP

FTLVAYLIAG VAWFVSKSPT RFAEVLVVAS PCPLILSAPI ALVAGMGRSS RHGVVIKSGT

MVEKLASAKT IAFDKTGTTT QGQLSVDQVQ PINAGTTAAE LVGLAASVEQ ESSHILARSI

VAYARKQDVP LKNITDLAEV SGAGVKAFVD GAEIRVGKKN FVTQESQETE KIDKTTIHIS

RNGTYLGRTT FTDTVRPEAK ETMEKLHQLH LQRILMLTGD QESVAETIAA EVGTTEVHGE

CLPQDKLTIL KELPKENHPV IMVGDGVNDA PSLAAADVGI AMGAHGATAA SETADVVILK

DDLSKVSQAV EIAQDTMKTA KQSVLIGIFI CVLLMLIAST GIIPALIGAM LQEVVDTVST

LSALRARRIG

EF079-1 (SEQ ID NO:297)

TAATTTCTAG CATCACCGAA GAAATTTTTA GAAAAACAAA GAGCCTGGGC CAATCACTGT

CCCAGGCTCT CATGCTTTAT TTTTAAGGAG GAAGCAATGA AGTCAAAAAA GAAACGTCGT

ATCATTGATG GTTTTATGAT TCTTTTACTG ATTATTGGAA TAGGTGCATT TGCGTATCCT

TTTGTTAGCG ATGCATTAAA TAACTATCTG GATCAACAAA TTATCGCTCA TTATCAAGCA

AAAGCAAGCC AAGAAAACAC CAAAGAAATG GCTGAACTTC AAGAAAAAAT GGAAAAGAAA

AACCAAGAAT TAGCGAAAAA AGGCAGCAAT CCTGGATTAG ATCCTTTTTC TGAAACGCAA

AAAACAACGA AAAAACCAGA CAAATCCTAT TTTGAAAGTC ATACGATTGG TGTTTTAACC

ATTCCAAAAA TAAATGTCCG TTTACCAATT TTTGATAAAA CGAATGCATT GCTATTGGAA

AAAGGAAGCT CCTTGTTAGA AGGAACCTCC TATCCTACAG GTGGTACGAA TACACATGCG

GTCATTTCAG GCCATCGTGG TCTCCCTCAA GCCAAATTAT TTACAGATTT GCCAGAATTA

AAAAAAGGCG ATGAATTTTA TATCGAAGTC AATGGGAAGA CGCTTGCTTA TCAAGTAGAT

CAAATAAAAA CCGTTGAACC AACTGATACA AAAGATTTAC ACATTGAGTC TGGCCAAGAT

CTCGTCACTT TATTAACTTG CACACCGTAT ATGATAAACA GTCATCGGTT ATTAGTTCGA

GGACATCGTA TCCCATATCA ACCAGAAAAA GCAGCAGCGG GGATGAAAAA AGTGGCACAA

CAACAAAATT TACTATTATG GACATTACTT TTAATTGCCT GTGCGTTAAT TATTAGCGGC

TTCATTATCT GGTACAAGCG ACGGAAAAAG ACGACCAGAA AACCAAAGTA G

EF079-2 (SEQ ID NO:298)

MKSKKKRRI IDGFMILLLI IGIGAFAYPE

VSDALNNYLD QQIIAHYQAK ASQENTKEMA ELQEKMEKKN QELAKKGSNP GLDPFSETQK

TTKKPDKSYF ESHTIGVLTI PKINVRLPIF DKTNALLLEK GSSLLEGTSY PTGGTNTHAV

ISGHRGLPQA KLFTDLPELK KGDEFYIEVN GKTLAYQVDQ IKTVEPTDTK DLHIESGQDL

VTLLTCTPYM INSHRLLVRG HRIPYQPEKA AAGMKKVAQQ QNLLLWTLLL IACALIISGF

IIWYKEPKKT TRKPK

EF079-3 (SEQ ID NO:299)

TCCT

TTTGTTAGCG ATGCATTAAA TAACTATCTG GATCAACAAA TTATCGCTCA TTATCAAGCA

AAAGCAAGCC AAGAAAACAC CAAAGAAATG GCTGAACTTC AAGAAAAAAT GGAAAAGAAA

AACCAAGAAT TAGCGAAAAA AGGCAGCAAT CCTGGATTAG ATCCTTTTTC TGAAACGCAA

AAAACAACGA AAAAACCAGA CAAATCCTAT TTTGAAAGTC ATACGATTGG TGTTTTAACC

ATTCCAAAAA TAAATGTCCG TTTACCAATT TTTGATAAAA CGAATGCATT GCTATTGGAA

AAAGGAAGCT CCTTGTTAGA AGGAACCTCC TATCCTACAG GTGGTACGAA TACACATGCG

GTCATTTCAG GCCATCGTGG TCTCCCTCAA GCCAAATTAT TTACAGATTT GCCAGAATTA

AAAAAAGGCG ATGAATTTTA TATCGAAGTC AATGGGAAGA CGCTTGCTTA TCAAGTAGAT

CAAATAAAAA CCGTTGAACC AACTGATACA AAAGATTTAC ACATTGAGTC TGGCCAAGAT

CTCGTCACTT TATTAACTTG CACACCGTAT ATGATAAACA GTCATCGGTT ATTAGTTCGA

GGACATCGTA TCCCATATCA ACCAGAAAAA GCAGCAGCGG GGATGAAAAA AGTGGCACAA

CAACAAAATT TACTATTATO GACATTACTT TTAATTGCCT GTGCGTTAAT TATTAGCGGC

TTCATTATCT GGTACAAGCG ACGGAAAAAG ACGACCAGAA AACCAA

EF079-4 (SEQ ID NO:300)

PF

VSDALNNYLD QQITAHYQAK ASQENTKEMA ELQEKNEKKN QELAKKGSNP GLDPFSETQK

TTKKPDKSYF ESHTTGVLTT PKINVRLPIF DKTNALLLEK GSSLLEGTSY PTGGTNTHAV

ISGHRGLPQA KLFTDLPELK KGDEFYTEVN GKTLAYQVDQ IKTVEPTDTK DLHTESGQDL

VTLLTCTPYM INSHRLLVRG HRIPYQPEKA AAGMKKVAQQ QNLLLWTLLL IACALILISGF

IIWYKRRKKT TRKP

EF080-1 (SEQ ID NO:301)

TAGTTACACT CGTTTAGGGC TAGCAACGTT AGGCATTTTC GCTCGACTCT TAGCACTCTT

TTTATTAGGA GGTTATTTCC TATGAAAAAA CGACTTTTAC CTATTTTTTT CCTAATACTT

CTTACCTTTG GCCTTGCCCT ACCCGTTTCG GCGGCTGAAA ATTCAATTGA TGATGGCGCA

CAATTACTGA CACCTGATCA AATCAACCAA CTAAAGCAAG AGATACAACC TTTAGAAGAA

AAAACAAAAG CCTCTGTCTT TATTGTAACC ACAAATAATA ATACCTATGG CGATGAACAA

GAATATGCAG ATCATTATCT TTTAAATAAA GTTGGCAAGG ACCAAAATGC GATTCTTTTT

CTCATTGATA TGGACTTACG GAAAATCTAC ATCTCTACTT CTGGAAACAT GATTGATTAT

ATGACAGATG CACGAATTGA TGATACCTTA GATAAAATAT GGGATAATAT GAGTCAAGGA

AATTATTTCG CGGCTGCTCA AACCTTTGTT CAGGAAACTC AAGCATTTGT TAATAAAGGG

GTTCCTGGGG GGCACTATCG TGTGGACAGC GAAACAGGTA AAATCACTCG TTATAAAGTC

ATTACCCCGC TGGAAATGGT AATTGCTTTT GCTGCTGCGC TGATACTCAG TTTGGTCTTC

TTAGGCATTA ATATTTCTAA ATATCAATTA AAATTTTCAA GTTATCAATA TCCCTTTAGG

GAAAAAACAA CTTTAAACTT AACCTCCCGC ACAGATCAGT TAACCAACTC TTTCATCACT

ACGCGTCGTA TTCCTAAAAA CAATGGCGGC AGTGGCGGAA TGGGCGGTGG TGGTAGCACC

ACCCACTCAA CTGGCGGCGG CACATTCGGT GGCGGCGGTC GAAGTTTTTA G

EF080-2 (SEQ ID NO:302)

MKKR LLPTFFLILL TFGLALPVSA AENSIDDGAQ

LLTPDQINQL KQEIQPLEEK TKASVFIVTT NNNTYGDEQE YADHYLLNKV GKDQNAILFL

IDMDLRKIYI STSGNMIDYM TDARIDDTLD KIWDNMSQGN YFAAAQTFVQ ETQAFVNKGV

PGGHYRVDSE TGKITRYKVI TPLEMVIAFA AALILSLVFL GINISKYQLK FSSYQYPFRE

KTTLNLTSRT DQLTNSFITT RRTPKNNGGS GGMGGGGSTT HSTGGGTFGG GGRSF

EF080-3 (SEQ ID NO:303)

GGCTGAAA ATTCAATTGA TGATGGCGCA

CAATTACTGA CACCTGATCA AATCAACCAA CTAAAGCAAG AGATACAACC TTTAGAAGAA

AAAACAAAAG CCTCTGTCTT TATTGTAACC ACAAATAATA ATACCTATGG CGATGAACAA

GAATATGCAG ATCATTATCT TTTAAATAAA GTTGGCAAGG ACCAAAATGC GATTCTTTTT

CTCATTGATA TGGACTTACG GAAAATCTAC ATCTCTACTT CTGGAAACAT GATTGATTAT

ATGACAGATG CACGAATTGA TGATACCTTA GATAAAATAT GGGATAATAT GAGTCAAGGA

AATTATTTCG CGGCTGCTCA AACCTTTGTT CAGGAAACTC AAGCATTTGT TAATAAAGGG

GTTCCTGGGG GGCACTATCG TGTGGACAGC GAAACAGGTA AAATCACTCG TTATAAAGTC

ATTACCCCGC TGGAAATGGT AATTGCTTTT GCTGCTGCGC TGATACTCAG TTTGGTCTTC

TTAGGCATTA ATATTTCTAA ATATCAATTA AAATTTTCAA GTTATCAATA TCCCTTTACG

GAAAAAACAA CTTTAAACTT AACCTCCCGC ACAGATCAGT TAACCAACTC TTTCATCACT

ACGCGTCGTA TTCCTAAAAA CAATGGCGGC AGTGGCGGAA TGGGCGGTGG TGGTAGCACC

ACCCACTCAA CTGGCGGCGG CACATTCGGT GGCGGCGGTC GAAGT

EF080-4 (SEQ ID NO:304)

AENS I DDGAQ

LLTPDQINQL KQEIQPLEEK TKASVFIVTT NNNTYGDEQE YADHYLLNKV GKDQNAILFL

IDMDLRKIYI STSGNNIDYM TDARIDDTLD KIWDNNSQGN YFAAAQTFVQ ETQAFVNKGV

PGGHYRVDSE TGKITRYKVT TPLEMVIAFA AALILSLVFL GINISKYQLK FSSYQYPFRE

KTTLNLTSRT DQLTNSFITT RRTPKNNGGS GGMGGGGSTT HSTGGGTFGG GGRS

EF081-1 (SEQ ID NO:305)

TGAATGGAAC CAAGCAATCG TAATAAAAAA TCTTCAAAAA AACCACTTAT TCTTGGTGTT

TCTGCCTTGG TTCTAATCGC TGCTGCCGGT GGCGGGTATT ATGCTTATAG TCAATGGCAA

GCCAAACAAG AATTAGCCGA AGCGAAGAAA ACAGCTACTA CATTTTTAAA CGTATTGTCA

AAACAGGAAT TTGATAAGTT ACCGTCCGTT GTTCAAGAAG CTAGCTTAAA GAAAAATGGC

TATGATACTA AATCTGTTGT TGAAAAATAC CAAGCAATTT ATTCAGGGAT TCAAGCAGAA

GGAGTCAAAG CTAGTGATGT TCAAGTCAAA AACGCGAAAG ACAATCAATA CACATTTACC

TATAAATTAT CGATGAGCAC GCCTTTAGGC GAAATGAAAG ATTTGTCTTA TCAATCAAGT

ATCGCCAAAA AAGGCGATAC CTACCAAATC GCTTGGAAGC CATCTTTAAT TTTTCCAGAT

ATGTCAGGAA ATGATAAAAT TTCGATTCAA GTAGATAATG CCAAACGTGG AGAAATTGTC

GATCGTAATG GTAGTGGGCT AGCAATTAAC AAAGTGTTTG ACGAAGTGGG CGTAGTGCCT

GGCAAACTCG GTTCTGCCGC AGAAAAAACA GCCAATATCA AAGCTTTTAG TGATAAATTC

GGCGTTTCTG TTGATGAAAT CAATCAAAAG TTAAGCCAAG GATGGGTCCA AGCAGACTCC

TTTGTACCAA TCACAGTCGC TTCTGAACCA GTGACAGAAT TACCAACAGG GGCTGCGACA

AAAGATACAG AGTCACGTTA TTATCCGCTG GGGGAAGCAN TGCGCAATTA A

EF081-2 (SEQ ID NO:306)

MERSNRNKKS SKKPLILGVS ALVLIAAAGG GYYAYSQWQA KQELAEAKKT ATTFLNVLSK

QEFDKLPSVV QEASLKKNGY DTKSVVEKYQ AIYSGIQAEG VKASDVQVKK AKDNQYTFTY

KLSMSTPLGE MKDLSYQSSI AKKGDTYQTA WKPSLIFPDM SGNDKISIQV DNAKRGEIVD

RNGSGLAINK VFDEVGVVPG KLGSGAEKTA NIKAFSDKFG VSVDETNQKL SQGWVQADSF

VPITVASEPV TELPTGAATK DTESRYYPLG EAXRN

EF081-3 (SEQ ID NO:307)

T GGCGGGTATT ATOOTTATAG TCAATGGCAA

GCCAAACAAG AATTAGCCGA AGCGAAGAAA ACAGCTACTA CATTTTTAAA CGTATTGTCA

AAACAGGAAT TTGATAAGTT ACCGTCCGTT GTTCAAGAAG CTAGCTTAAA GAAAAATGGC

TATGATACTA AATCTGTTGT TGAAAAATAC CAAGCAATTT ATTCAGGGAT TCAAGCAGAA

GGAGTCAAAG CTAGTGATGT TCAAGTCAAA AAGGCGAAAG ACAATCAATA CACATTTACC

TATAAATTAT CGATGAGCAC GCCTTTAGGC GAAATGAAAG ATTTGTCTTA TCAATCAAGT

ATCGCCAAAA AAGGCGATAC CTACCAAATC GCTTGGAAGC CATCTTTAAT TTTTCCAGAT

ATGTCAGGAA ATGATAAAAT TTCGATTCAA GTAGATAATG CCAAACGTGG AGAAATTGTC

GATCGTAATG GTAGTGGGCT AGCAATTAAC AAAGTGTTTG ACGAAGTGGG CGTAGTGCCT

GGCAAACTCG GTTCTGGCGC AGAAAAAACA GCCAATATCA AAGCTTTTAG TGATAAATTC

GGCGTTTCTG TTGATGAAAT CAATCAAAAG TTAAGCCAAG GATGGGTCCA AGCAGACTCC

TTTGTACCAA TCACAGTCGC TTCTGAACCA GTGACAGAAT TACCAACAGG GGCTGCGACA

AAAGATACAG AGTCACGTTA TTATCCGCTG GGGG

EF081-4 (SEQ ID NO:308)

G GYYAYSQWQA KQELAEAKKT ATTFLNVLSK

QEFDKLPSVV QEASLKKNGY DTKSVVEKYQ AIYSGIQAEG VKASDVQVKK AKDNQYTFTY

KLSMSTPLGE MKDLSYQSSI AKKGDTYQIA WKPSLIFPDM SGNDKISIQV DNAKRGETVD

RNGSGLAINK VFDEVGVVPG KLGSGAEKTA NIKAFSDKFG VSVDEINQKL SQGWVQADSF

VPITVASEPV TELPTGAATK DTESRYYPLG

EF082-1 (SEQ ID NO:309)

TAAAAAATGA AAAAGATCGT GCGCATTTCA AGCATTTTGT TCGTTGCTAC GCCTCTTATG

CTTTTAAATA GTTCAAAAGT TGAAGCAGCT CAAGTCGCTT CTATTCAATC CAACGCTGAT

ATTACGTTTG CTCTTGATAA TACTGTCACG CCACCTGTCA ACCCGACGAA CCCTTCTCAG

CCTGTGACAC CTAATCCTGC TGATCCTCAT CAACCTGGTA CAGCCGGACC CCTTAGTATT

GACTATGTTT CAAATATCCA TTTTGGATCA AAACAAATTC AAGCCGGAAC AGCGATCTAT

TCGGCACAAC TGGATCAAGT GCAAAATAGT ACTGGCGATT TAATTAGCGT GCCAAACTAT

GTTCAAGTAA CTGACAAACG TGGTCTAAAT CTTGGCTGGA AATTATCAGT TAAACAGAGT

GCGCAATTTG CTACAAGTGA TTCAACACCC GCTGTTTTGG ATAATGCATC CTTGACCTTT

TTAGCAGCAA CACCCAATTC AACACAGTTA CTTTCTTTGG CGCCATTAAC GGTCCCAGTA

ACCTTGGATC CAACTGGTGC CGCCACTTCT CCTGTGGCGA CTGCCGCTCT TTCAACAGGA

ATGGGCACTT GGACATTAGC TTTTGGTAGC GGANCGACCG CTGCTCAAGG CATTCAATTA

ACTGTTCCTG CGACAACGAA AAAAGTTGCA GCTAAACAAT ATAAAACAAC GCTTACTTGG

ATTTTGGATG ATACACCACT TTAA

EF082-2 (SEQ ID NO:310)

MKKIVRISS ILFVATPLNL LNSSKVEAAQ VASIQSNADI TFALDNTVTP PVNPTNPSQP

VTPNPADPHQ PGTAGPLSID YVSNIHFGSK QIQAGTAIYS AQLDQVQNST GDLISVPNYV

QVTDKRGLNL GWKLSVKQSA QFATSDSTPA VLDNASLTFL AATPNSTQLL SLAPLTVPVT

LDPTGAATSP VATAALSTGM GTWTLAFGSG XTAAQGIQLT VPATTKKVAA KQYKTTLTWI

LDDTPL

EF082-3 (SEQ ID NO:311)

AGCT CAAGTCGCTT CTATTCAATC CAACGCTGAT

ATTACGTTTG CTCTTGATAA TACTGTCACG CCACCTGTCA ACCCGACGAA CCCTTCTCAG

CCTGTGACAC CTAATCCTGC TGATCCTCAT CAACCTGGTA CAGCCGGACC CCTTAGTATT

GACTATGTTT CAAATATCCA TTTTGGATCA AAACAAATTC AAGCCCGAAC AGCGATCTAT

TCGGCACAAC TGGATCAAGT GCAAAATAGT ACTGGCGATT TAATTAGCGT GCCAAACTAT

GTTCAAGTAA CTGACAAACG TGGTCTAAAT CTTGGCTGGA AATTATCAGT TAAACAGAGT

GCGCAATTTG CTACAAGTGA TTCAACACCC GCTGTTTTGG ATAATGCATC CTTGACCTTT

TTAGCAGCAA CACCCAATTC AACACAGTTA CTTTCTTTGG CGCCATTAAC GGTCCCAGTA

ACCTTGGATC CAACTGGTGC CGCCACTTCT CCTGTCGCGA CTGCCGCTCT TTCAACAGGA

ATGGGCACTT GGACATTAGC TTTTGGTAGC GGANCGACCG CTGCTCAAGG CATTCAATTA

ACTGTTCCTG CGACAACGAA AAAAGTTGCA GCTAAACAAT ATAAAACAAC GCTTACTTGG

ATTTTGGATG ATACACCACT

EF082-4 (SEQ ID NO:312)

AQ VASIQSNADI TFALDNTVTP PVNPTNPSQP

VTPNPADPHQ PGTAGPLSID YVSNIHFGSK QIQAGTAIYS AQLDQVQNST GDLISVPNYV

QVTDKRGLNL GWKLSVKQSA QFATSDSTPA VLDNASLTFL AATPNSTQLL SLAPLIVPVT

LDPTGAATSP VATAALSTGM GTWTLAFGSG XTAAQCIQLT VPATTKKVAA KQYKTTLTWI

LDDTP

EF083-1 (SEQ ID NO:313)

TAATTTAAAA GACAAGGAGA AATAAAAATG AAAAAGAAAA TTTTAGCAGG AGCGCTTGTC

GCTCTGTTTT TTATGCCTAC AGCTATGTTT GCCGCAAAAG GAGACCAAGG TGTGGATTGG

GCGATTTATC AAGGTGAACA AGGTCGCTTT GGCTATGCAC ATGATAAATT CGCTATTGCC

CAGATTGGAG GCTACAATGC TAGCGGTATT TATGAACAAT ACACATATAA AACGCAAGTG

GCAAGTGCTA TTGCCCAAGG TAAACGTGCG CATACCTATA TTTGGTATGA CACTTGGGGA

AACATGGACA TTGCGAAAAC AACAATGGAT TACTTTTTGC CACGTATTCA AACGCCTAAA

AATTCCATCG TTGCATTAGA TTTTGAACAT GGAGCGTTGG CTAGTGTTCC AGATGGATAT

GGAGGATATG TAAGTTCAGA TGCCGAAAAA GCAGCAAATA CAGAGACAAT TTTGTACGGT

ATGCGCAGAA TCAAACAGGC TGGCTATACT CCAATGTATT ACAGCTATAA GCCATTTACA

CTAAATCATG TAAACTATCA ACAAATCATC AAAGAGTTTC CTAACTCTTT ATGGATTGCT

GCGTATCCTA TCGATGGTGT GTCACCATAT CCATTGTATG CTTATTTCCC AAGCATGGAT

GGTATTGGTA TTTGGCAATT CACATCCGCT TATATTGCAG GTGGTTTAGA TGGTAACGTA

GATTTAACAG GAATTACGGA TAGTGGTTAT ACAGATACCA ATAAACCAGA AACGGATACG

CCAGCAACAG ATGCAGGCGA AGAAATTGAA AAAATACCTA ATTCTGATGT TAAAGTTGGC

GATACCGTCA AAGTGAAATT TAATGTAGAT GCTTGGGCAA CTGGGGAAGC TATTCCGCAA

TGGGTAAAAG GAAACAGCTA CAAAGTGCAA GAAGTAACTG GAAGCAGAGT ATTGCTTGAA

GGTATCTTGT CATGGATTAG CAAAGGTGAT ATTGAATTAT TGCCAGACGC AACAGTCGTC

CCTGATAAGC AACCAGAAGC GACTCATGTG GTACAATACG GAGAAACATT ATCAAGTATT

GCTTATCAAT ATGGAACAGA CTATCAAACG TTGGCGGCAT TAAATGGATT GGCTAATCCA

AATCTTATTT ATCCTGGTCA AGTTTTGAAA GTCAATGGAT CGGCAACAAG TAATGTCTAC

ACGGTTAAAT ACGGCGATAA TTTATCTAGT ATTGCAGCAA AACTTGGCAC TACTTATCAA

GCTTTAGCTG CATTAAACGG ATTAGCAAAT CCTAACTTGA TTTATCCAGG TCAAACATTG

AATTATTAA

EF083-2 (SEQ ID NO:314)

MK KKILAGALVA LFFMPTAMFA AKGDQGVDWA IYQGEQGRFG YAHDKFAIAQ

IGGYNASGIY EQYTYKTQVA SAIAQGKRAH TYIWYDTWGN MDIAKTTMDY FLPRIQTPKN

SIVALDFEHG ALASVPDGYG GYVSSDAEKA ANTETILYGM RRIKQAGYTP MYYSYKPFTL

NHVNYQQIIK EFPNSLWIAA YPIDGVSPYP LYAYFPSMDG GIWQFTSAY IAGGLDGNVD

LTGITDSGYT DTNKPETDTP ATDAGEEIEK IPNSDVKVGD TVKVKFNVDA WATGEAIPQW

VKGNSYKVQE VTGSRVLLEG ILSWISKGDI ELLPDATVVP DKQPEATHVV QYGETLSSIA

YQYGTDYQTL AALNGLANPN LIYPGQVLKV NGSATSNVYT VKYGDNLSSI AAKLGTTYQA

LAALNGLANP NLIYPGQTLN Y

EF083-3 (SEQ ID NO:315)

AAAAG GAGACCAAGG TGTGGATTGG

GCGATTTATC AAGGTCAACA AGGTCGCTTT GGCTATGCAC ATGATAAATT CGCTATTGCC

CAGATTGGAG GCTACAATGC TAGCGGTATT TATGAACAAT ACACATATAA AACGCAAGTG

GCAAGTGCTA TTGCCCAAGG TAAACGTGCG CATACCTATA TTTGGTATGA CACTTGGGGA

AACATGGACA TTGCGAAAAC AACAATGGAT TACTTTTTGC CACGTATTCA AACGCCTAAA

AATTCCATCG TTGCATTAGA TTTTGAACAT GGAGCGTTGG CTAGTGTTCC AGATGGATAT

GGACGATATG TAAGTTCAGA TGCCGAAAAA GCAGCAAATA CAGAGACAAT TTTGTACGGT

ATGCGCAGAA TCAAACAGGC TGGCTATACT CCAATGTATT ACAGCTATAA GCCATTTACA

CTAAATCATG TAAACTATCA ACAAATCATC AAAGAGTTTC CTAACTCTTT ATCGATTGCT

GCGTATCCTA TCGATGGTGT GTCACCATAT CCATTGTATG CTTATTTCCC AAGCATGGAT

GGTATTGGTA TTTGGCAATT CACATCCGCT TATATTGCAG GTGGTTTAGA TGGTAACGTA

GATTTAACAG GAATTACGGA TAGTGGTTAT ACAGATACCA ATAAACCAGA AACGGATACG

CCAGCAACAG ATGCAGGCGA AGAAATTGAA AAAATACCTA ATTCTGATGT TAAAGTTGGC

GATACCGTCA AAGTGAAATT TAATGTAGAT GCTTGGGCAA CTGGGGAAGC TATTCCGCAA

TGGGTAAAAG GAAACAGCTA CAAAGTGCAA GAAGTAACTG GAAGCAGAGT ATTGCTTGAA

GGTATCTTGT CATGGATTAG CAAAGGTGAT ATTGAATTAT TGCCAGACGC AACAGTCGTC

CCTGATAAGC AACCAGAAGC GACTCATGTG GTACAATACG GAGAAACATT ATCAAGTATT

GCTTATCAAT ATGGAACAGA CTATCAAACG TTGGCGGCAT TAAATGGATT GGCTAATCCA

AATCTTATTT ATCCTGGTCA AGTTTTGAAA GTCAATGGAT CGGCAACAAG TAATGTCTAC

ACGGTTAAAT ACGGCGATAA TTTATCTAGT ATTGCACCAA AACTTGGCAC TACTTATCAA

GCTTTAGCTG CATTAAACGG ATTAGCAAAT CCTAACTTGA TTTATCCAGG TCAAACATTG

AAT

EF083-4 (SEQ ID NO:316)

KGDQGVDWA IYQGEQGRFG YAHDKFAIAQ

IGGYNASGIY EQYTYKTQVA SAIAQGKRAH TYIWYDTWGN MDIAKTTMDY FLPRIQTPKN

SIVALDFEHG ALASVPDGYG GYVSSDAEKA ANTETILYGM RRIKQAGYTP MYYSYKPFTL

NHVNYQQIIK EFPNSLWTAA YPIDGVSPYP LYAYFPSMDG IGIWQFTSAY IAGCLDGNVD

LTGITDSGYT DTNKPETDTP ATDAGEEIEK TPNSDVKVGD TVKVKFNVDA WATGEAIPQW

VKGNSYKVQE VTGSRVLLEG ILSWISKGDI ELLPDATVVP DKQPEATHVV QYGETLSSIA

YQYGTDYQTL AALNGLANPN LIYPGQVLKV NGSATSNVYT VKYGDNLSSI AAKLGTTYQA

LAALNGLANP NLIYPGQTLN

EF084-1 (SEQ ID NO:317)

TAGTCAAACG TTTATTTTTT CCTTAAATCC AGAAAAAATC CCGTAATTAT GGTACACTAC

CTATTGAATT GGACGAGAAC TATGAAGAAA TTTGATGTAA TTATTGTCGG TGCTGGGACG

AGCGGTATGA TGGCCACGAT TGCGGCCGCC GAAGCAGGCG CTCAAGTATT ATTGATTGAA

AAAAATCGCC GTGTTGGGAA AAAATTATTA ATGACTGGTG GCGGCCGCTG TAATGTAACC

AATAATCGGC CCGCAGAAGA AATCATTTCA TTTATTCCTG GGAATGGAAA ATTTTTATAC

AGCGCATTTT CACAATTTGA TAACTATGAT ATCATGAACT TTTTTGAATC CAATGGTATT

CACTTAAAAG AAGAAGATCA CGGACGCATG TTCCCTGTTA CAGATAAATC GAAGTCAATT

GTTGATGCGC TATTTAACCG CATTAACGAA TTAGGAGTCA CTGTTTTTAC AAAAACACAG

GTCACAAAAT TACTACGAAA AGACGATCAA ATAATTGGCG TTGAAACCGA ACTGGAAAAA

ATTTATGCAC CGTGTGTTGT ATTAACAACT GGCGGCCGCA CTTATCCTTC CACAGGAGCA

ACTGGTGATG GCTATAAACT AGCCAAAAAA ATGGGGCATA CCATCAGCCC GCTCTACCCT

ACCGAATCAC CTATTATTTC TGAAGAACCT TTTATCCTGG ATAAAACGTT GCAAGGTCTC

TCTTTACAAG ATGTTAATTT AACTGTTTTG AACCAAAAAG GAAAACCTTT AGTTAATCAT

CAAATGGATA TGCTGTTTAC ACATTTTGGC ATTTCAGGAC CTGCCGCGCT CCGCTGTTCT

AGTTTTATTA ACCAAGAATT AACTCGCAAC GGTAATCAAC CTGTCACGGT AGCCTTGGAT

GTGTTTCCGA CAAAATCTTT TGAAGAAGTG CCTGCCAAAC AACTAACAGA AAAGCAACCN

CTTTCCTTTG TGGAACTACT GAAAGACTTT CAGTTCACTG TTACGAAAAC ATTGCCTTTG

GAAAAATCTT TTGTCACAGG CGGTGGGATT TCCCTCAAAG AAGTGACCCC TAAAACAATG

GAGAGCAAAT TAGTCAATGG TTTATTTTTT GCTGGTGAAC TTTTAGATAT TAATGGCTAT

ACTGGAGGCT ACAATGTTAC AGCTGCATTT GTCACTGGAC ATGTTGCTGG CTCCCATGCC

GCAGAAATTG CAGAATACAC CTATTTACCA ATTGAAGAAG TCTAA

EF084-2 (SEQ ID NO:318)

MKKF DVIIVGAGTS GHMATIAAAE AGAQVLLIEK

NRRVGKKLLM TGGGRCNVTN NRPAEEIISF IPGNGKFLYS AFSQFDNYDI MNFFESNGIH

LKEEDHGRMF PVTDKSKSIV DALFNRINEL GVTVFTKTQV TKLLRKDDQI IGVETELEKI

YAPCVVLTTG GRTYPSTGAT GDGYKLAKKN GHTISPLYPT ESPIISEEPF ILDKTLQGLS

LQDVNLTVLN QKGKPLVNHQ MDMLFTHFGI SGPAALRCSS FINQELTRNG NQPVTVALDV

FPTKSFEEVP AKQLTEKQRL SFVELLKDFQ FTVTKTLPLE KSFVTGGGIS LKEVTPKTME

SKLVNGLFFA GELLDINGYT GGYNVTAAFV TCHVAGSHAA EIAEYTYLPI EEV

EF084-3 (SEQ ID NO:319)

C GAAGCAGGCG CTCAAGTATT ATTGATTGAA

AAAAATCGCC GTGTTGGGAA AAAATTATTA ATGACTGGTG GCGGCCGCTG TAATGTAACC

AATAATCGGC CCGCAGAAGA AATCATTTCA TTTATTCCTG GGAATGGAAA ATTTTTATAC

AGCGCATTTT CACAATTTGA TAACTATGAT ATCATGAACT TTTTTGAATC CAATGGTATT

CACTTAAAAG AAGAAGATCA CGGACGCATG TTCCCTGTTA CAGATAAATC GAAGTCAATT

GTTGATGCGC TATTTAACCG CATTAACGAA TTAGGAGTCA CTGTTTTTAC AAAAACACAG

GTCACAAAAT TACTACGAAA AGACGATCAA ATAATTGGCG TTGAAACCGA ACTGGAAAAA

ATTTATGCAC CGTGTGTTGT ATTAACAACT GGCGGCCGCA CTTATCCTTC CACAGGACCA

ACTGGTGATG GCTATAAACT AGCCAAAAAA ATGGGGCATA CCATCAGCCC GCTCTACCCT

ACCGAATCAC CTATTATTTC TGAAGAACCT TTTATCCTGG ATAAAACGTT GCAAGGTCTC

TCTTTACAAG ATGTTAATTT AACTGTTTTG AACCAAAAAG GAAAACCTTT AGTTAATCAT

CAAATGGATA TGCTGTTTAC ACATTTTGGC ATTTCAGGAC CTGCCGCGCT CCGCTGTTCT

AGTTTTATTA ACCAAGAATT AACTCGCAAC GGTAATCAAC CTGTCACGGT AGCCTTGGAT

GTGTTTCCGA CAAAATCTTT TGAAGAAGTG CCTGCCAAAC AACTAACAGA AAAGCAACGN

CTTTCCTTTG TGGAACTACT GAAAGACTTT CAGTTCACTG TTACGAAAAC ATTGCCTTTG

GAAAAATCTT TTGTCACAGG CGGTGGGATT TCCCTCAAAG AAGTGACCCC TAAAACAATG

GAGAGCAAAT TAGTCAATGG TTTATTTTTT GCTGGTGAAC TTTTAGATAT TAATGGCTAT

ACTGGAGGCT ACAATGTTAC AGCTGCATTT GTCACTGGAC ATGTTGCTGG CTCCCATGCC

GCAGAAATTG CAGAATACAC CTATTTACCA ATTGAAGAAG TC

EF084-4 (SEQ ID NO:320)

E AGAQVLLIEK

NRRVGKKLLM TGGGRCNVTN NRPAEEIISF IPGNGKFLYS AFSQEDNYDI MNEFESNGIH

LKEEDHGRNF PVTDKSKSIV DALFNRINEL GVTVFTKTQV TKLLRKDDQI IGVETELEKI

YAPCVVLTTG GRTYPSTGAT GDGYKLAKKM GHTISPLYPT ESPIISEEPF ILDKTLQGLS

LQDVNLTVLN QKGKPLVNHQ HDMLFTHFGI SGPAALRCSS FINQELTRNG NQPVTVALDV

FPTKSFEEVP AKQLTEKQRL SFVELLKDFQ FTVTKTLPLE KSFVTGGGIS LKEVTPKTME

SKLVNGLFFA GELLDINGYT GGYNVTAAFV TGHVAGSHAA EIAEYTYLPI EEV

EF085-1 (SEQ ID NO:321)

TAACCCATGA AATCATTTTG TCCCGCATAT GGGGATATGA CTTTGACGGT GATGGCAGCA

CAGTCCACAC TCATATCAAA AATCTGCGGG CGAACTGCCG GAAAATATCA TCAAAACCAT

CCGCGGTGTA GGTTACCGAT TGGAGGAATC ATTATAATGG AAAGAAAAGG GATTTTCATT

AAGGTTTTTT CCTATACGAT CATTGTCCTG TTACTGCTTG TCGGTGTAAC GGCAACACTG

TTTGCACAGC AATTTGTGTC TTATTTCAGA GCGATGGAAG CACAGCAAAC AGTAAAATCC

TATCAGCCAT TGGTGGAACT GATTCAGAAT AGCGATAGGC TTGATATGCA AGAGGTGGCA

GGGCTGTTTC ACTACAATAA CCAATCCTTT GAGTTTTATA TTGAAGATAA AGAGGGAAGC

GTACTCTATG CCACACCGAA TGCCGATACA TCAAATAGTG TTAGGCCCGA CTTTCTTTAT

GTGGTACATA GAGATGATAA TATTTCGATT GTTGCTCAAA GCAAGGCAGG TGTGGGATTG

CTTTATCAAG GGCTGACAAT TCGGGGAATT GTTATGATTG CGATAATGGT TGTATTCAGC

CTTTTATGCG CGTATATCTT TGCGCGGCAA ATGACAACGC CGATCAAAGC CTTAGCGGAC

AGTGCGAATA AAATGGCAAA CCTGAAAGAA GTACCGCCGC CGCTGGAGCG AAAGGATGAG

CTTGGCGCAC TGGCTCACGA CATGCATTCC ATGTATATCA GGCTGAAAGA AACCATCGCA

AGGCTGGAGG ATGAAATCGC AAGGGAACAT GAGTTGGAGG AAACACAGCG ATATTTCTTT

GCGGCAGCCT CTCATGAGTT AAAAACGCCC ATCGCGGCTG TAAGCGTTCT GTTGGAGGGA

ATGCTTGAAA ATATCGGTGA CTACAAAGAC CATTCTAAGT ATCTGCGCGA ATGCATCAAA

ATGATGGACA GGCAGGGCAA AACCATTTCC GAAATACTGG AGCTTGTCAG CCTGAACGAT

GGGAGAATCG TACCCATAGC CGAACCGCTG GACATAGGGC GCACGGTTGC CGAGCTGCTA

CCCGATTTTC AAACCTTGGC AGAGGCAAAC AACCAGCGGT TCGTCACAGA TATTCCAGCC

GGACAAATTG TCCTGTCCGA TCCGAAGCTG ATCCAAAAGG CGCTATCCAA TGTCATATTG

AATGCGGTTC AGAACACGCC CCAGGGAGGT GAGGTACGGA TATGGAGTGA GCCTGGGGCT

GAAAAATACC GTCTTTCCGT TTTGAACATG GGCGTTCACA TTGATGATAC TGCACTTTCA

AAGCTGTTCA TCCCATTCTA TCGCATTGAT CAGGCGCGAA GCAGCAAAAA GTGGGCGAAG

CGGTTTGGGG CTTGCCATCG TACAAAAAAC GCTGGATGCC ATGAGCCTCC AATATGCGCT

GGAAAACACC TCAGATGGCG TTTTGTTCTG GCTGGATTTA CCGCCCACAT CAACACTATA

AATATTTAA

EF085-2 (SEQ ID NO:322)

MERKGIFIK

VESYTIIVEL LLVGVTATLF AQQFVSYFRA MEAQQTVKSY QPLVELIQNS DRLDMQEVAG

LFHYNNQSFE FYIEDKEGSV LYATPNADTS NSVRPDFLYV VHRDDNISIV AQSKACVGLL

YQGLTIRGIV MIAIMVVFSL LCAYIFARQM TTPIKALADS ANKMANLKEV PPPLERKDEL

GALAHDMHSM YIRLKETIAR LEDEIAREHE LEETQRYFFA AASHELKTPI AAVSVLLEGM

LENIGDYKDH SKYLRECIKM MDRQGKTISE ILELVSLNDG RIVPIAEPLD IGRTVAELLP

DEQTLAEANN QRFVTDIPAG QIVLSDPKLI QKALSNVILN AVQNTPQGGE VRIWSEPGAE

KYRLSVLNMG VHIDDTALSK LFIPEYRIDQ ARSSKKWAKR FGACHRTKNA GCHEPPICAG

KHLRWRFVLA GETAHINTIN I

EF085-3 (SEQ ID NO:323)

GC AATTTGTGTC TTATTTCAGA GCGATGGAAG CACAGCAAAC AGTAAAATCC

TATCAGCCAT TGGTGGAACT GATTCAGAAT AGCGATAGGC TTGATATGCA AGAGGTGGCA

CGGCTGTTTC ACTACAATAA CCAATCCTTT GAGTTTTATA TTGAAGATAA AGAGGGAAGC

GTACTCTATG CCACACCGAA TGCCGATACA TCAAATAGTG TTAGGCCCGA CTTTCTTTAT

GTGGTACATA GAGATGATAA TATTTCGATT GTTGCTCAAA GCAAGGCAGG TGTGGGATTG

CTTTATCAAG GGCTGACAAT TCGGGGAATT GTTATGATTG CGATAATGGT TGTATTCAGC

CTTTTATGCG CGTATATCTT TGCGCGGCAA ATGACAACGC CGATCAAAGC CTTAGCGGAC

AGTGCGAATA AAATGGCAAA CCTGAAAGAA GTACCGCCGC CGCTGGAGCG AAAGGATGAG

CTTCGCGCAC TGGCTCACGA CATGCATTCC ATGTATATCA GGCTGAAACA AACCATCGCA

AGGCTGGAGG ATGAAATCGC AAGGGAACAT GAGTTGGAGG AAACACAGCG ATATTTCTTT

GCGGCAGCCT CTCATGAGTT AAAAACGCCC ATCGCGGCTG TAAGCGTTCT GTTGGAGGGA

ATGCTTGAAA ATATCGGTGA CTACAAAGAC CATTCTAAGT ATCTGCGCGA ATGCATCAAA

ATGATGCACA GGCAGGGCAA AACCATTTCC GAAATACTGG AGCTTGTCAG CCTCAACGAT

GGGACAATCG TACCCATAGC CGAACCGCTG GACATAGGGC GCACGGTTGC CGAGCTGCTA

CCCGATTTTC AAACCTTGGC AGAGGCAAAC AACCAGCGCT TCGTCACAGA TATTCCAGCC

GGACAAATTG TCCTGTCCGA TCCGAAGCTG ATCCAAAAGG CGCTATCCAA TGTCATATTG

AATGCGGTTC AGAACACGCC CCAGGGAGGT GAGGTACGGA TATGGAGTCA GCCTGGGGCT

GAAAAATACC GTCTTTCCGT TTTGAACATG GGCGTTCACA TTGATGATAC TGCACTTTCA

AAGCTGTTCA TCCCATTCTA TCGCATTGAT CAGGCGCGAA C-CAGCAAAAA GTGGGCGAAG

CGGTTTGGGG CTTGCCATCG TACAAAAAAC GCTGGATGCC ATGAGCCTCC AATATGCGCT

GGAAAACACC TCAGATGGCG TTTTGTTCTG GCTGGATTTA CCGCCCACAT CAACACTATA

AATATTT

EF085-4 (SEQ ID NO:324)

QFVSYEPA MEAQQTVKSY QPLVELIQNS DRLDMQEVAG

LFHYNNQSFE FYIEDKEGSV LYATPNADTS NSVRPDFLYV VHRDDNISIV AQSKAGVGLL

YQGLTIRGIV MIAIMVVFSL LCAYIFARQM TTPIKALADS ANKNANLKEV PPPLERKDEL

GALAHDMHSM YIRLKETIAR LEDEIAREHE LEETQRYFEA AASHELKTPI AAVSVLLEGM

LENIGDYKDH SKYLRECIKM MDRQGKTISE ILELVSLNDG RIVPIAEPLD IGRTVAELLP

DFQTLAEANN QRFVTDIPAG QIVLSDPKLI QKALSNVILN AVQNTPQGGE VRIWSEPGAE

KYRLSVLNMG VHIDDTALSK LFIPFYRIDQ ARSSKKWAKR FGACHRTKNA GCHEPPICAG

KHLRWRFVLA GFTAHINTIN I

EF086-1 (SEQ ID NO:325)

TAACTGGTGG GATTGGCAAA TTGGTTCCGC GCAGCGCTAA CAGATACATT GATTTTATTA

CATGATGACC TATTGAATAC AGATGCAGAA AAATTAAATA AATTTACTGC TCCGCTGATG

CTGTATGCAA AAGATCCAAA CATACAATGG CCAATTTATC GTGCAACAGG AGCTAACTTA

ACAGATATTT CAATCACCGT TTTAGGTACT GGACTTTTGT TAGAAGATAA TCAACGCCTA

GTACAAGTAC AAGAAGCTGT TCCGTCCGTT TTAAAAAGTG TTTCCTCTGG TGATGGCTTA

TATCCTGATG GTTCCTTGAT TCAACATGGT TATTTTCCGT ACAACGCCAG TTACGGGAAT

GAGTTGCTAA AACGGTTTGG ACGAATTCAG ACTATTTTAC AAGGTTCCGA CTGGGAGATG

AATGACCCTA ACATTAGTAA TTTATTTAAT GTTGTGGATA AAGGTTACTT ACAATTGATG

GTAAATGGAA AAATGCCATC GATGGTTTCT GGTAGAAGTA TTTCCAGAGC GCCAGAAACG

AATCCTTTTA CTACAGAGTT TGAATCGGGT AAAGAAACAA TAGCTAATTT AACCTTAATT

GCAAAATTTG CACCAGAAAA TTTAAGAAAT GACATTTATA CATCTATCCA AACGTGGCTT

CAACAAAGTG GGTCATACTA TCATTTCTTT AAAAAACCAA GAGATTTTGA AGCGTTAATT

GACTTGAAAA ATGTAGTGAA TAGTGCGTCA CCTGCCCAAG CCACACCAAT GCAATCTTTA

AATGTATATG GTTCGATGGA TCGAGTCCTA CAGAAAAATA ACGAATATGC GGTGGGGATC

AGTATGTATT CACAACGTGT CGGAAACTAT GAATTTGGGA ATACGGAAAA TAAAAAAGGC

TGGCATACAG CAGACGGCAT GCTTTATTTA TACAATCAAG ACTTTGCTCA GTTTGATGAA

GGATACTGGG CAACGATCGA TCCATATCGA TTACCAGGAA CGACAGTTGA CACAAGAGAA

TTGGCAAATG GTGCTTATAC AGGGAAACGC AGTCCCCAGT CATGGGTAGG TGGCTCAAAT

AATGGACAGG TTGCCTCTAT AGGAATGTTT TTAGATAAAA GTAATGAAGG AATGAACTTA

GTTGCTAAAA AATCTTGGTT CTTATTAGAT CGTCAAATCA TTAATTTGGG AAGTGGCATT

ACTGGTACGA CAGATGCTTC GATTGAAACA ATCCTCGATA ATCGGATGAT TCATCCACAG

GAAGTGAAGC TTAACCAAGG TTCAGACAAA GATAATTCTT GGATTAGTTT AAGCGCAGCG

ANTCCATTGA ATAACATTGG CTATGTTTTT CCTAATTCNA TGAATACGCT TGATGTTCAA

ATAGAAGAAC GCTCTGGTCG CTACGGAGAT ATTAACGAAT ACTTTGTTAA TGATAAAACC

TATACAAATA CATTTGCTAA AATTAGTAAA AATTATGCCA AGACTGTTGA AAATGGTACT

TACGAATATT TAACAGTGGT TGGGAAAACG AATGAAGAAA TCCCAGCTCT TTCTAAAAAC

AAAGGCTATA CTGTTCTAGA AAATACAGCA AACTTACAAG CCATTGAAGC AGGTAATTAT

GTCATGATGA ATACATGGAA TAATGACCAA GAAATTGCAG GACTGTATGC GTATGATCCA

ATGTCGGTTA TTTCAGAAAA AATTGATAAC GGTGTTTATC GCTTAACTCT TGCGAATCCT

TTACAAAATA ATGCATCCGT TTCTATTGAA TTTGATAAGG GCATTCTTGA AGTAGTCGCA

GOGGACCOAG AAATTTCTGT TGACCAAAAT ATTATCACTT TAAATAGTGC GGGGTTAAAT

GGCAGCTCGC GTTCAATCAT TGTTAAAACA ACTCCTGAAG TAACGAAAGA AGCGTTAGAA

AAATTAATTC AGGAACAAAA AGAACACCAA GAAAAAGACT ACACCGCAAG CAGCTGGAAA

GTCTACAGCG AAGCATTGAA ACAAGCACAA ACTGTGGCAG ATCAAACAAC AGCAACGCAA

GCAGAAGTAG ACCAAGCAGA AACAGAGTTA CGTTCGGCAG TGAAGCAATT GGTAAAAGTG

CCAACTAAAG AAGTAGATAA AACCAACTTG TTGAAAATCA TCAAAGAAAA CGAGAAACAC

CAAGAAAAAG ACTACACCGC AAGCAGTTGG AAAGTCTACA GTGAAGCATT GAAGCAAGCG

CAAACTGTGG CAGATCAAAC AACAGCAACG CAAGCAGAAG TAGACCAACC AGAAGCAAAA

CTACGTTCGG CAGTGAAGCG ATTAACATTG AAAAATAGTG GGGAAAATAA AAAGGAGCAA

AAAAATGGGG GGAATAATGG ACACTTAAAT ACTAGTACAG GAGTTGATCA AACTGGTACG

AAACAAGTTA AGCCATCAAC CCAAGGTGGT TTCAGAAAAG CTAGCCAATT TTTACCGAGC

ACAGGAGAAA AGAAATCGAT CGCGCTTGTG ATTATTGGTC TTCTAGTTAT CGCCAGTGGG

TGTCTTTTAG TTTTTCGTAA AAGTAAATCG AAGAAGTAA

EF086-2 (SEQ ID NO:326)

LVGLANWFRA ALTDTLILLH DDLLNTDAEK LNKFTAPLML YAKDPNIQWP IYRATGANLT

DISITVLGTG LLLEDNQRLV QVQEAVPSVL KSVSSGDGLY PDGSLTQHGY FPYNGSYGNE

LLKGFGRIQT ILQGSDWEMN DPNISNLFNV VDKGYLQLMV NGKMPSMVSG RSISRAPETN

PFTTEFESGK ETIANLTLIA KFAPENLRIW IYTSIQTWLQ QSGSYYHFFK KPRDFEALID

LKNVVNSASP AQATPMQSLN VYGSMDRVLQ KNNEYAVGIS MYSQRVGNYE FGNTENKKGW

HTADGMLYLY NQDFAQFDEG YWATIDPYRL PGTTVDTREL ANGAYTGKRS PQSWVGGSNN

GQVASIGMFL DKSNEGMNLV AKKSWFLLDG QIINLGSGIT GTTDASIETI LDNRMIHPQE

VKLNQGSDKD NSWISLSAAX PLNNIGYVFP NSMNTLDVQI EERSGRYGDI NEYFVNDKTY

TNTFAKISKN YGKTVENGTY EYLTVVGKTN EEIAALSKNK GYTVLENTAN LQAIEAGNYV

MMNTWNNDQE IAGLYAYDPM SVISEKIDNG VYRLTLANPL QNNASVSIEF DKGTLEVVAA

DPEISVDQNI ITLNSAGLNG SSRSTIVKTT PEVTKEALEK LIQEQKEHQE KDYTASSWKV

YSEALKQAQT VADQTTATQA EVDQAETELR SAVKQLVKVP TKEVDKTNLL KIIKENEKHQ

EKDYTASSWK VYSEALKQAQ TVADQTTATQ AEVDQAEAKL RSAVKRLTLK NSGENKKEQK

NGGNNGHLNT STGVDQTGTK QVKPSSQCGF RKASQFLPST GEKKSIALVI IGLLVIASGC

LLVFRKSKSK K

EF086-3 (SEQ ID NO:327)

ACCAGAAAA TTTAAGAAAT GACATTTATA CATCTATCCA AACGTGGCTT

CAACAAAGTG GGTCATACTA TCATTTCTTT AAAAAACCAA GACATTTTGA AGCGTTAATT

GACTTGAAAA ATGTAGTGAA TAGTGCGTCA CCTGCCCAAG CGACACCAAT GCAATCTTTA

AATGTATATG GTTCGATGGA TCGAGTCCTA CAGAAAAATA ACGAATATGC GGTGGGGATC

AGTATGTATT CACAACGTGT CGGAAACTAT CAATTTGCGA ATACGGAAAA TAAAAAAGGC

TGGCATACAG CAGACGGCAT GCTTTATTTA TACAATCAAG ACTTTGCTCA GTTTGATGAA

GGATACTGGG CAACGATCGA TCCATATCGA TTACCAGGAA CGACAGTTGA CACAAGAGAA

TTGGCAAATG GTGCTTATAC AGGGAAACGC AGTCCCCAGT CATGGGTAGG TGGCTCAAAT

AAT

EF086-4 (SEQ ID NO:328)

PENLEND IYTSIQTWLQ QSGSYYHFFK KPRDFEALID

LKNVVNSASP AQATPMQSLN VYGSMDRVLQ KNNEYAVGIS MYSQRVGNYE FGNTENKKGW

HTADGMLYLY NQDFAQFDEG YWATIDPYRL PGTTVDTREL ANGAYTGKRS PQSWVGGSNN

EF087-1 (SEQ ID NO:329)

TAACTGGTGG GATTGGCAAA TTGGTTCCGC GCAGCGCTAA CAGATACATT GATTTTATTA

CATGATGACC TATTGAATAC AGATGCAGAA AAATTAAATA AATTTACTGC TCCGCTGATG

CTGTATGCAA AAGATCCAAA CATACAATGC CCAATTTATC GTGCAACAGG AGCTAACTTA

ACAGATATTT CAATCACCGT TTTAGGTACT GGACTTTTGT TAGAAGATAA TCAACGCCTA

GTACAAGTAC AAGAAGCTGT TCCGTCCGTT TTAAAAAGTG TTTCCTCTGG TGATGGCTTA

TATCCTGATG GTTCCTTGAT TCAACATGGT TATTTTCCGT ACAACGGCAG TTACGGGAAT

GAGTTGCTAA AAGCGTTTGG ACCAATTCAG ACTATTTTAC AAGGTTCCGA CTGGGAGATG

AATGACCCTA ACATTAGTAA TTTATTTAAT GTTGTGGATA AAGGTTACTT ACAATTGATG

GTAAATGGAA AAATGCCATC GATGGTTTCT GGTACAAGTA TTTCCAGAGC GCCAGAAACG

AATCCTTTTA CTACAGAGTT TGAATCGGGT AAAGAAACAA TAGCTAATTT AACCTTAATT

GCAAAATTTG CACCAGAAAA TTTAAGAAAT GACATTTATA CATCTATCCA AACGTGGCTT

CAACAAAGTG GGTCATACTA TCATTTCTTT AAAAAACCAA GAGATTTTGA AGCGTTAATT

GACTTGAAAA ATGTAGTGAA TAGTGCGTCA CCTGCCCAAG CGACACCAAT GCAATCTTTA

AATGTATATG GTTCGATGGA TCGAGTCCTA CAGAAAAATA ACGAATATGC GGTGGGGATC

AGTATGTATT CACAACGTGT CGGAAACTAT GAATTTGGGA ATACGGAAAA TAAAAAAGGC

TGGCATACAG CAGACGGCAT GCTTTATTTA TACAATCAAG ACTTTGCTCA GTTTGATGAA

GGATACTCGG CAACGATCGA TCCATATCGA TTACCAGGAA CGACAGTTGA CACAAGAGAA

TTGGCAAATG GTGCTTATAC AGGGAAACGC AGTCCCCAGT CATGGGTAGG TGGCTCAAAT

AATGGACAGG TTGCCTCTAT AGGAATGTTT TTAGATAAAA GTAATGAAGG AATGAACTTA

GTTGCTAAAA AATCTTGGTT CTTATTAGAT GGTCAAATCA TTAATTTGGG AAGTGGCATT

ACTGGTACGA CAGATGCTTC GATTGAAACA ATCCTCGATA ATCGGATGAT TCATCCACAG

GAAGTGAAGC TTAACCAACG TTCAGACAAA GATAATTCTT GGATTAGTTT AAGCGCAGCG

ANTCCATTGA ATAACATTCG CTATGTTTTT CCTAATTCNA TGAATACGCT TGATGTTCAA

ATAGAACAAC GCTCTGGTCG CTACGGAGAT ATTAACGAAT ACTTTGTTAA TGATAAAACC

TATACAAATA CATTTCCTAA AATTAGTAAA AATTATGGCA AGACTGTTGA AAATGGTACT

TACGAATATT TAACAGTGGT TGGGAAAACG AATGAAGAAA TCGCAGCTCT TTCTAAAAAC

AAAGGCTATA CTGTTCTAGA AAATACAGCA AACTTACAAG CCATTGAAGC AGGTAATTAT

GTCATGATGA ATACATGGAA TAATGACCAA GAAATTGCAG GACTGTATGC GTATGATCCA

ATGTCGGTTA TTTCAGAAAA AATTGATAAC GGTGTTTATC GCTTAACTCT TGCGAATCCT

TTACAAAATA ATGCATCCGT TTCTATTGAA TTTGATAAGG GCATTCTTGA AGTAGTCGCA

GCGGACCCAG AAATTTCTGT TGACCAAAAT ATTATCACTT TAAATAGTGC GGGGTTAAAT

GGCAGCTCGC GTTCAATCAT TGTTAAAACA ACTCCTGAAG TAACGAAAGA AGCGTTAGAA

AAATTAATTC AGGAACAAAA AGAACACCAA GAAAAAGACT ACACCGCAAG CAGCTGGAAA

GTCTACAGCG AAGCATTGAA ACAAGCACAA ACTGTGGCAG ATCAAACAAC AGCAACGCAA

GCAGAAGTAG ACCAAGCAGA AACAGAGTTA CGTTCGGCAG TGAAGCAATT GGTAAAAGTG

CCAACTAAAG AAGTAGATAA AACCAACTTG TTGAAAATCA TCAAAGAAAA CGAGAAACAC

CAAGAAAAAG ACTACACCGC AAGCAGTTGG AAAGTCTACA GTGAAGCATT GAAGCAAGCG

CAAACTGTCG CAGATCAAAC AACAGCAACG CAAGCAGAAG TAGACCAAGC AGAAGCAAAA

CTACGTTCGG CAGTGAAGCG ATTAACATTG AAAAATAGTG GGGAAAATAA AAAGGAGCAA

AAAAATGGGG GGAATAATGG ACACTTAAAT ACTAGTACAG GAGTTGATCA AACTGGTACG

AAACAAGTTA AGCCATCAAG CCAAGGTGGT TTCAGAAAAG CTAGCCAATT TTTACCGAGC

ACAGGAGAAA AGAAATCGAT CGCGCTTGTG ATTATTGGTC TTCTAGTTAT CGCCAGTGGG

TGTCTTTTAG TTTTTCGTAA AAGTAAATCG AAGAAGTAA

EF087-2 (SEQ ID NO:330)

LVGLANWFRA ALTDTLILLH DDLLNTDAEK LNKFTAPLML YAKDPNTQWP IYRATGANLT

DISITVLGTG LLLEDNQRLV QVQEAVPSVL KSVSSGDGLY PDGSLIQHGY FPYNGSYGNE

LLKGFGRIQT ILQGSDWEMN DPNTSNLFNV VDKGYLQLMV NGKNPSMVSG RSISRAPETN

PFTTEFESGK ETIANLTLIA KFAPENLRND IYTSIQTWLQ QSGSYYHFFK KPRDFEALID

LKNVVNSASP AQATPMQSLN VYGSMDRVLQ KNNEYAVGIS MYSQRVGNYE FGNTENKKGW

HTADGMLYLY NQDFAQFDEG YWATIDPYRL PGTTVDTREL ANGAYTGKRS PQSWVGGSNN

GQVASIGMFL DKSNEGMNLV AKKSWFLLDG QIINLGSGIT GTTDASIETI LDNRMIHPQE

VKLNQGSDKD NSWISLSAAX PLNNTGYVFP NSMNTLDVQI EERSGRYGDI NEYFVNDKTY

TNTFAKISKN YGKTVENGTY EYLTVVGKTN EEIAALSKNK GYTVLENTAN LQAIEAGNYV

MMNTWNNDQE IACLYAYDPM SVISEKTDNG VYRLTLANPL QNNASVSIEF DKGILEVVAA

DPEISVDQNI ITLNSAGLNG SSRSIIVKTT PEVTKEALEK LIQEQKEHQE KDYTASSWKV

YSEALKQAQT VADQTTATQA EVDQAETELR SAVKQLVKVP TKEVDKTNLL KIIKENEKHQ

EKDYTASSWK VYSEALKQAQ TVADQTTATQ AEVDQAEAKL RSAVKRLTLK NSGENKKEQK

NGGNNGHLNT STGVDQTGTK QVKPSSQGGF RKASQFLPST GEKKSIALVI IGLLVIASGC

LLVFRKSKSK K

EF087-3 (SEQ ID NO:331)

A ATCGGATGAT TCATCCACAG

GAAGTGAAGC TTAACCAAGG TTCAGACAAA GATAATTCTT GGATTAGTTT AAGCGCAGCG

ANTCCATTGA ATAACATTGG CTATGTTTTT CCTAATTCNA TGAATACGCT TGATGTTCAA

ATAGAAGAAC GCTCTGGTCG CTACGGAGAT ATTAACGAAT ACTTTGTTAA TGATAAAACC

TATACAAATA CATTTGCTAA AATTAGTAAA AATTATGGCA AGACTGTTCA AAATGGTACT

TACGAATATT TAACAGTGGT TGGGAAAACG AATGAAGAAA TCGCAGCTCT TTCTAAAAAC

AAAGGCTATA CTGTTCTAGA AAATACAGCA AACTTACAAG CCATTGAAGC AGGTAATTAT

GTCATGATGA ATACATGCAA TAATGACCAA GAAATTGCAG GACTGTATGC CTATGATCCA

ATGTCGGTTA TTTCAGAAAA AATTGATAAC GGTGTTTATC GCTTAACTCT TGCGAATCCT

TTACAAAATA ATGCATCC

EF087-4 (SEQ ID NO:332)

NRI4IHPQE

VKLNQGSDKD NSWISLSAAX PLNNIGYVFP NSHNTLDVQI EERSGRYGDT NEYFVNDKTY

TNTFAKISKN YCKTVENGTY EYLTVVGKTN EEIAALSKNK GYTVLENTAN LQAIEAGNYV

MMNTWNNDQE IAGLYAYDPM SVISEKIDNG VYRLTLANPL QNNAS

EF088-1 (SEQ ID NO:333)

TAACTGGTGG GATTGGCAAA TTGGTTCCGC GCAGCGCTAA CAGATACATT GATTTTATTA

CATGATGACC TATTGAATAC AGATGCAGAA AAATTAAATA AATTTACTGC TCCGCTGATG

CTGTATCCAA AAGATCCAAA CATACAATGG CCAATTTATC GTGCAACAGG AGCTAACTTA

ACAGATATTT CAATCACCGT TTTAGGTACT GGACTTTTGT TAGAAGATAA TCAACGCCTA

GTACAAGTAC AAGAAGCTGT TCCGTCCGTT TTAAAAAGTG TTTCCTCTGG TGATGGCTTA

TATCCTGATG GTTCCTTCAT TCAACATGGT TATTTTCCGT ACAACGGCAC TTACGGGAAT

GAGTTGCTAA AAGGGTTTGG ACGAATTCAG ACTATTTTAC AAGGTTCCGA CTGGGAGATG

AATGACCCTA ACATTAGTAA TTTATTTAAT GTTGTGGATA AAGGTTACTT ACAATTGATG

GTAAATGGAA AAATGCCATC GATGGTTTCT GGTAGAAGTA TTTCCAGAGC GCCAGAAACG

AATCCTTTTA CTACAGAGTT TGAATCGGGT AAAGAAACAA TAGCTAATTT AACCTTAATT

GCAAAATTTG CACCAGAAAA TTTAAGAAAT GACATTTATA CATCTATCCA AACGTGGCTT

CAACAAAGTG GGTCATACTA TCATTTCTTT AAAAAACCAA GAGATTTTGA AGCGTTAATT

GACTTGAAAA ATGTAGTCAA TAGTGCGTCA CCTGCCCAAG CGACACCAAT GCAATCTTTA

AATGTATATG GTTCGATGGA TCGAGTCCTA CAGAAAAATA ACGAATATGC GGTGGGGATC

AGTATGTATT CACAACGTGT CGGAAACTAT GAATTTGGGA ATACGGAAAA TAAAAAAGGC

TGGCATACAG CAGACGGCAT GCTTTATTTA TACAATCAAG ACTTTGCTCA GTTTGATGAA

GGATACTGGG CAACGATCCA TCCATATCGA TTACCAGGAA CGACAGTTGA CACAAGAGAA

TTGGCAAATG GTGCTTATAC AGGGAAACGC AGTCCCCAGT CATGGGTAGG TGGCTCAAAT

AATGGACAGG TTGCCTCTAT AGGAATGTTT TTAGATAAAA GTAATGAAGG AATGAACTTA

GTTGCTAAAA AATCTTGGTT CTTATTAGAT GGTCAAATCA TTAATTTGGG AAGTGGCATT

ACTOCTACCA CAGATGCTTC GATTGAAACA ATCCTCGATA ATCGGATGAT TCATCCACAG

GAAGTGAAGC TTAACCAAGG TTCAGACAAA GATAATTCTT GGATTAGTTT AAGCGCAGCG

ANTCCATTGA ATAACATTGG CTATGTTTTT CCTAATTCNA TGAATACGCT TGATGTTCAA

ATAGAAGAAC GCTCTGGTCG CTACGGAGAT ATTAACGAAT ACTTTGTTAA TGATAAAACC

TATACAAATA CATTTGCTAA AATTAGTAAA AATTATGGCA AGACTGTTGA AAATGGTACT

TACGAATATT TAACAGTGGT TGGGAAAACG AATGAAGAAA TCGCAGCTCT TTCTAAAAAC

AAAGGCTATA CTGTTCTAGA AAATACAGCA AACTTACAAG CCATTGAAGC AGGTAATTAT

GTCATGATGA ATACATGGAA TAATGACCAA GAAATTGCAG GACTGTATGC GTATGATCCA

ATGTCGGTTA TTTCAGAAAA AATTGATAAC GGTGTTTATC GCTTAACTCT TGCGAATCCT

TTACAAAATA ATGCATCCGT TTCTATTGAA TTTGATAAGG GCATTCTTGA AGTAGTCGCA

GCGGACCCAG AAATTTCTGT TGACCAAAAT ATTATCACTT TAAATAGTGC GGGGTTAAAT

GGCAGCTCGC GTTCAATCAT TGTTAAAACA ACTCCTCAAG TAACGAAAGA AGCGTTAGAA

AAATTAATTC AGGAACAAAA AGAACACCAA GAAAAAGACT ACACCCCAAG CAGCTGGAAA

GTCTACAGCG AAGCATTGAA ACAACCACAA ACTGTGGCAG ATCAAACAAC AGCAACGCAA

GCAGAAGTAG ACCAAGCAGA AACAGAGTTA CGTTCGGCAG TGAAGCAATT GGTAAAAGTG

CCAACTAAAG AAGTAGATAA AACCAACTTG TTGAAAATCA TCAAAGAAAA CGAGAAACAC

CAACAAAAAG ACTACACCGC AAGCAGTTGG AAAGTCTACA GTGAAGCATT GAAGCAAGCG

CAAACTGTGG CAGATCAAAC AACAGCAACG CAAGCAGAAG TAGACCAAGC AGAACCAAAA

CTACGTTCGG CAGTGAAGCG ATTAACATTG AAAAATAGTG GGGAAAATAA AAAGGAGCAA

AAAAATGGGG GGAATAATGG ACACTTAAAT ACTAGTACAG GAGTTGATCA AACTGGTACG

AAACAAGTTA AGCCATCAAG CCAAGGTGGT TTCAGAAAAG CTAGCCAATT TTTACCGAGC

ACAGGAGAAA AGAAATCGAT CGCGCTTGTG ATTATTGGTC TTCTAGTTAT CGCCAGTGGG

TGTCTTTTAG TTTTTCGTAA AAGTAAATCG AAGAAGTAA

EF088-2 (SEQ ID NO:334)

LVGLANWFRA ALTDTLILLH DDLLNTDAEK LNKFTAPLML YAKDPNIQWP IYRATGANLT

DISITVLGTG LLLEDNQRLV QVQEAVPSVL KSVSSCDGLY PDGSLIQHGY FPYNGSYGNE

LLKGFGRIQT ILQGSDWENM DPNISNLFNV VDKGYLQLMV NGKMPSMVSG RSISRAPETN

PFTTEFESGK ETIANLTLIA KFAPENLRND IYTSIQTWLQ QSGSYYHFFK KPRDFEALID

LKNVVNSASP AQATPMQSLN VYGSMDRVLQ KNNEYAVGIS MYSQRVGNYE FGNTENKKGW

HTADGMLYLY NQDFAQFDEG YWATIDPYRL PGTTVDTREL ANGAYTGKRS PQSWVGGSNN

GQVASIGMFL DKSNEGMNLV AKKSWFLLDG QLLNLGSGIT GTTDASIETI LDNRMIHPQE

VKLNQGSDKD NSWISLSAAX PLNNIGYVFP NSHNTLDVQI EERSGRYGDT NEYFVNDKTY

TNTFAKISKN YGKTVENGTY EYLTVVGKTN EEIAALSKNK GYTVLENTAN LQAIEAGNNV

MMNTWNNDQE IAGLYAYDPM SVISEKIDNG VYRLTLANPL QNNASVSIEF DKGILEVVAA

DPEISVDQNI ITLNSAGLNG SSRSIIVKTT PEVTKEALEK LIQEQKEHQE KDYTASSWKV

YSEALKQAQT VADQTTATQA EVDQAETELR SAVKQLVKVP TKEVDKTNLL KIIKENEKHQ

EKDYTASSWK VYSEALKQAQ TVADQTTATQ AEVDQAEAKL RSAVKRLTLK NSGENKKEQK

NGGNNGHLNT STGVDQTGTK QVKPSSQGGF RKASQFLPST GEKKSIALVI IGLLVIASGC

LLVFRKSKSK K

EF088-3 (SEQ ID NO:335)

A ACTCCTGAAG TAACGAAAGA AGCGTTAGAA

AAATTAATTC AGCAACAAAA AGAACACCAA GAAAAACACT ACACCGCAAG CAGCTGGAAA

GTCTACAGCG AAGCATTGAA ACAAGCACAA ACTGTGGCAG ATCAAACAAC AGCAACGCAA

GCAGAAGTAG ACCAAGCAGA AACAGAGTTA CGTTCGGCAG TGAAGCAATT GGTAAAAGTG

CCAACTAAAG AAGTAGATAA AACCAACTTG TTGAAAATCA TCAAAGAAAA CGAGAAACAC

CAAGAAAAAG ACTACACCGC AAGCAGTTGG AAAGTCTACA GTGAAGCATT GAAGCAAGCG

CAAACTGTGG CAGATCAAAC AACAGCAACG CAAGCAGAAG TAGACCAAGC AGAAGCAAAA

CTACGTTCGG CAGTGAAGCG ATTAACATTG AAAAATAGTG GGGAAAATAA AAAGGAGCAA

AAAAATGGGG GGAATAATGG ACACTTAAAT ACTAGTACAG GAGTTGATCA AACTGGTACG

AAACAAGTTA AGCCATCAAG CCAAGGTGGT TTCAGAAAAG CTAGCCAATT TTTACCGAGC

ACAGGAGAAA AGAAA

EF088-4 (SEQ ID NO:336)

T PEVTKEALEK LIQEQKEHQE KDYTASSWKV

YSEALKQAQT VADQTTATQA EVDQAETELR SAVKQLVKVP TKEVDKTNLL KIIKENEKHQ

EKDYTASSWK VYSEALKQAQ TVADQTTATQ AEVDQAEAKL RSAVKRLTLK NSGENKKEQK

NGGNNGHLNT STGVDQTGTK QVKPSSQGGF RKASQFLPST GEKK

EF089-1 (SEQ ID NO:337)

TGACAGATAC ACCTGCTAAC ACAGGAAACT AAGAACGACA GCATACACGC AAGATCGGGA

TATAGGTCAA AAATTTTTTG GCTTATCTTT CGGTCTTTTG GTGCTTATAA TACAACAAAG

AATGACAGAC ATAGGAGAAT GAATATGAAC AGATGGAAAG TATATGCAAC GGTAATCGCT

TGTATGTTAT TTGGCTGGAT TGGCGTGGAG GCGCACGCTT CTGAATTTAA TTTTGCGGTC

ACACCAACAA TTCCCGAAAA TCAAGTGGAT AAATCAAAAA CCTACTTTGA CTTAAAAATG

GCGCCTCGTG CCAAACAAAC CGTAGAAATT CAGTTACGCA ATGATACAGA TGAAGACATT

ACCATTGAAA ATACGGTGAA CTCAGCGACA ACAAATTTAA ATGGCGTAGT AGAATATGGC

CAAAACGGGA TCAAACCTGA CAAAACCTTA CGTTTTAACT TAAAAGATTA TGTGGAAGCA

CCGAAAGAAA TCATCTTGCC GAAGCATTCC CAAAAGACCT TACCTTTAAC CATTACGATG

CCTAAAGATT CTTTTGATGG CGTGATGGCT GGCGGTATAA CACTCAAAGA GAAAAAGAAA

GAAACAACGA CTTCTGCGGA TCAATCAAAA GGGTTAGCTA TTAATAATGA ATACTCCTAT

GTTGTGGCTA TTATTCTTCA GCAAAATGAG ACAAAGGTTC AACCAGATTT AAAATTACTG

GGGGTTAAAC CAGGCCAAGT CAACGCGCGA AACGTCATCA ATGTTTCTTT ACAAAACCCA

CAAGCGGCCT ATTTAAACCA ATTACATTTA ATCAACACTG TTTCAAAAGG AGGCGAAACG

CTTTACCAAT CCGATACTCA GGATATGCAA GTGGCGCCAA ACTCTAACTT TAGTTACCCA

ATTTCTTTAA AAGGGGAACG ATTAACGCCA GGAAAATATG TCTTGAAATC AACCGCCTAT

GGTGTAAAAG ATGAAAAGGG CACCTATCAA GTCAAAGGCG CCAATGGTGA AGAACGGTAC

CTGTACAAAT GGGAATTTAC AAAAGAATTT ACTATTTCTG GGGACGTCGC TAAAGAATTA

AATGAAAAAG ACGTAACCAT TAAAGGAACC AATTGGTGGT TGTATCTACT GATTGCATTA

ATCATTCTAG CGCTGCTCTT ATTGATTTTC TTCTTGTATC GTAAAAAGAA AAAAGAGGAA

GAACAACAAT CTGAGCAATA A

EF089-2 (SEQ ID NO:338)

HNR WKVYATVTAC

MLFGWTGVEA HASEFNFAVT PTTPENQVDK SKTYFDLKMA PGAKQTVEIQ LRNDTDEDIT

IENTVNSATT NLNGVVEYGQ NGIKPDKTLR FNLKDYVEAP KETILPKHSQ KTLPLTTTMP

KDSFDGVMAG GITLKEKKKE TTTSADQSKG LAINNEYSYV VAITLQQNET KVQPDLKLLG

VKPCQVNARN VINVSLQNPQ AAYLNQLHLI NTVSKGGETL YQSDTEDMQV APNSNFSYPI

SLKGERLTPG KYVLKSTAYG VKDEKGTYQV KGANGEERYL YKWEFTKEFT ISGDVAKELN

EKDVTIKGTN WWLYLLIALI ILALLLLIFF LYRKKKKEEE QQSEQ

EF089-3 (SEQ ID NO:339)

T CTGAATTTAA TTTTGCGGTC

ACACCAACAA TTCCCGAAAA TCAAGTGGAT AAATCAAAAA CCTACTTTGA CTTAAAAATG

GCGCCTGGTG CCAAACAAAC CGTAGAAATT CAGTTACGCA ATGATACAGA TGAAGACATT

ACCATTGAAA ATACGGTGAA CTCAGCGACA ACAAATTTAA ATGGCGTAGT AGAATATGGC

CAAAACGGGA TCAAACCTGA CAAAACCTTA CGTTTTAACT TAAAAGATTA TGTGGAAGCA

CCGAAAGAAA TCATCTTGCC GAAGCATTCC CAAAAGACCT TACCTTTAAC CATTACGATG

CCTAAAGATT CTTTTGATGG CGTGATGGCT GCCGGTATAA CACTCAAAGA GAAAAAGAAA

GAAACAACGA CTTCTGCGGA TCAATCAAAA GGGTTAGCTA TTAATAATGA ATACTCCTAT

GTTGTGGCTA TTATTCTTCA GCAAAATGAG ACAAAGCTTC AACCAGATTT AAAATTACTG

GGGGTTAAAC CAGGCCAAGT CAACGCGCGA AACGTCATCA ATGTTTCTTT ACAAAACCCA

CAAGCGGCCT ATTTAAACCA ATTACATTTA ATCAACACTG TTTCAAAAGG AGGCGAAACG

CTTTACCAAT CCGATACTGA GGATATGCAA GTGGCGCCAA ACTCTAACTT TACTTACCCA

ATTTCTTTAA AAGGGGAACG AT

EF089-4 (SEQ ID NO:340)

SEFNFAVT PTIPENQVDK SKTYFDLKMA PGAKQTVEIQ LRNDTDEDIT

TENTVNSATT NLNGVVEYGQ NGIKPDKTLR FNLKDYVEAP KEIILPKHSQ KTLPLTITMP

KDSFDGVMAG GITLKEKKKE TTTSADQSKG LAINNEYSYV VAIILQQNET KVQPDLKLLG

VKPGQVNARN VINVSLQNPQ AAYLNQLHLI NTVSKGGETL YQSDTEDMQV APNSNFSYPI

SLKGER

EF090-1 (SEQ ID NO:341)

TAGTCTCTAA GAAATAAACC TAAAATTATT GATATAAAGG ATGAACAAAT GAAAAAAGAA

GAAATGCAAA TGCGTAATAC ACGTCGTCAA AAATCAGGAA AAAATAATAA AAAGAAAGTA

ATTATTACTT CTTTGGTTGG ACTAGCTCTG GTTGCTGGGG GCAGTTATGT TTATTTTCAA

AGTCACTTTT TNCCAACCAC AAAAGTAAAT GGAGTTTCTG TAGGCTGGTT AAATCTAAAT

GCTGCAGAAG AAAAATTAGC GCAAGTTAAT CAAACCGAAG AAGTTGTGGT TCAAACGGGG

ACAAAAGAAG AAAAAATTCA ACTTCCTAAA AAATACCAAT TGGATCAAAA ATTTTTAAAA

GACCATTTAC ACAGTAGCAA GGTGAAGCTA CCGTTAAACG AGGCATTCAA AAAAGAACTA

GAAGCCAAAT TAGCAACTTT GAGTTTTCCA GAGGGGAAAC CAAGCAAAAA TGCGAGTATC

CGTCGAGGCA ATGGCACTTT TGAAATTGTT CCCGAAGAAC AAGGCACAGT AGTGGACACA

CAGCGCTTAA ACCAGCAGAT TATTGCGGAT GTTGAAGCGG GAAAAGGCAA CTATCAATAT

AATGCCAAAG ATTTTTATAA AGCCCCTGAA ATTACAAAAG AGGATCAAAC GTTAAAGGCA

ACATTGACAA CGCTCAATAA CAAGTTAAAT AAAACAATTA CAGTTGATAT TAATGGTGAA

AAAGTAGCCT TTGATAAAAC ACAAATTCAA AACGTGCTGA ATGATGATGG CACAATCAAC

AAAGAAAAAC TAACTACTTG GGTGACACAA TTAGAAACAA CATATGGTTC TGCTAATCAA

CCAGTTTTAT TTACAGATGT TCACGGCACG ACACGTCGTT TTAAAAACAA CGGAAGTTAT

GGCTGGTCGA TTGATGCGGC CAAAACGCAA GAACTACTAG TAAACGCGCT GAATAGCCAA

GAACAAACGA ATGCAATCAC TGCTCCGTTG GTTGGTGATA CCAAAGAAAA TAGTAAAATT

GCCAATAATT ACATTGAAAT TGATTTAAAA GATCAAAAAA TGTATTGTTT CATTGATGGC

AAAAAAATAG TCACCACAGA TGTCATTACT GGCAGATATA ACAAAGGAAC CGCAACAGTA

CCAGGATTCC ATACAATTTT ATATCGGACA ACCGATGTGA ATTTAGAAGG TCAAATGCTT

GATGGTTCTC GATACAGTGT GCCAGTAAAA TATTGGATGC CGTTATTAAG TCAAGGGGCC

GTTCTCACAC AAATCGGGAT TCATCACTCC GACCATAAAT TCGATAAGTA TGOCGATAAA

GAAGCCTTTA AAACCGATGC TGGTAGTAAT GGCTGTATCA ATACGCCAGC AACAGAAGTT

TCAAAAATCT TTGATGTATC CTATGACGGA ATGCCGGTAA TTATTTATGG ACATATCTAT

GATGATGCAC CAGGTGAATT TGATAAACCT GTAGATTACG GCGAAGAAGT ATAA

EF090-2 (SEQ ID NO:342)

MRNTRRQK SGKNNKKKVI TTSLVGLALV AGCSYVYFQS

HFXPTTKVNG VSVGWLNVNA AEEKLAQVNQ TEEVVVQTGT KEEKIQLPKK YQLDQKFLKD

HLHSSKVKLP LNEAFKKELE AKLATLSFPE GKPSKNASIR RGNGTFEIVP EEQGTVVDTQ

RLNQQITADV EAGKGNYQYN AKDFYKAPET TKEDQTLKAT LTTLNNKLNK TITVDINGEK

VAFDKTQIQN VLNDDGTINK EKLTTWVTQL ETTYGSANQP VLFTDVHGTT RRFKNNGSYG

WSTDGAKTQE LLVNALNSQE QTNAITAPLV GDTKENSKIA NNYTEIDLKD QKMYCFIDGK

KIVTTDVITG RYNKGTATVP GFHTILYRTT DVNLEGQMLD GSRYSVPVKY WMPLLSQGGV

VTQIGIHDSD HKLDKYGDKE AFKTDAGSNG CINTPGTEVS KIFDVSYDGM PVIIYGHIYD

DAPGEFDKPV DYGEEV

EF090-3 (SEQ ID NO:343)

CAC AAAAGTAAAT CGAGTTTCTG TACGCTGGTT AAATGTAAAT

GCTGCAGAAC AAAAATTACC GCAAGTTAAT CAAACCGAAC AAGTTGTGGT TCAAACGGGC

ACAAAAGAAG AAAAAATTCA ACTTCCTAAA AAATACCAAT TGCATCAAAA ATTTTTAAAA

GACCATTTAC ACAGTAGCAA GGTGAAGCTA CCGTTAAACG AGGCATTCAA AAAAGAACTA

CAAGCCAAAT TAGCAACTTT GAGTTTTCCA GAGGGGAAAC CAAGCAAAAA TGCGAGTATC

CGTCGAGCCA ATGGCACTTT TGAAATTCTT CCCGAAGAAC AAGGCACAGT AGTGGACACA

CAGCGCTTAA ACCAGCAGAT TATTGCGGAT GTTGAACCGG GAAAAGCCAA CTATCAATAT

AATGCCAAAC ATTTTTATAA AGCCCCTGAA ATTACAAAAC ACCATCAAAC GTTAAAGGCA

ACATTGACAA CGCTCAATAA CAAGTTAAAT AAAACAATTA CAGTTCATAT TAATGGTGAA

AAAGTAGCCT TTGATAAAAC ACAAATTCAA AACGTGCTGA ATCATGATGG CACAATCAAC

AAACAAAAAC TAACTACTTG GGTGACACAA TTAGAAACAA CATATGGTTC TGCTAATCAA

CCAGTTTTAT TTACAGATCT TCACGCCACG ACACGTCGTT TTAAAAACAA CGCAACTTAT

GGCTGGTCGA TTGATGGGGC CAAAACGCAA GAACTACTAG TAAACGCGCT GAATAGCCAA

CAACAAACGA ATGCAATCAC TGCTCCGTTG GTTGGTGATA CCAAACAAAA TAGTAAAATT

GCCAATAATT ACATTGAAAT TGATTTAAAA GATCAAAAAA TGTATTGTTT CATTGATGGC

AAAAAAATAG TCACCACAGA TGTCATTACT CGCAGATATA ACAAAGGAAC CGCAACAGTA

CCAGGATTCC ATACAATTTT ATATCGGACA ACCGATGTGA ATTTAGAAGG TCAAATGCTT

CATGGTTCTC GATACAGTGT GCCAGTAAAA TATTGGATGC CGTTATTAAG TCAAGGGGGC

GTTGTCACAC AAATCGGGAT TCATGACTCC GACCATAAAT TGGATAACTA TGCCGATAAA

GAAGCCTTTA AAACCGATGC TGGTAGTAAT GGCTGTATCA ATACGCCAGG AACAGAAGTT

TCAAAAATCT TTGATGTATC CTATGACGGA ATGCCGGTAA TTATTTATGC ACATATCTAT

GATGATGCAC CACGTGAATT TGATAAACCT GTAGATTACG GCGAAGAAGT AT

EF090-4 (SEQ ID NO:344)

TKVNG VSVGWLNVNA AEEKLAQVNQ TEEVVVQTGT KEEKIQLPKK YQLDQKFLKD

HLHSSKVKLP LNEAFKKELE AKLATLSFPE GKPSKNASIR RCNGTFEIVP EEQGTVVDTQ

RLNQQIJADV EAGKGNYQYN AKDFYKAPEI TKEDQTLKAT LTTLNNKLNK TITVDINGEK

VAFDKTQIQN VLNDDGTINK EKLTTWVTQL ETTYGSANQP VLFTDVHGTT RRFKNNGSYG

WSIDGAKTQE LLVNALNSQE QTNAITAPLV CDTKENSKIA NNYIEIDLKD QKMYCFIDGK

KIVTTDVITG RYNKGTATVP GFHTILYRTT DVNLEGQMLD GSRYSVPVKY WMPLLSQGCV

VTQIGIHDSD HKLDKYGDKE AFKTDAGSNG CINTPGTEVS KIFDVSYDGM PVIIYGHIYD

DAPGEFDKPV DYGEEV

EF091-1 (SEQ ID NO:345)

TAATTGGNGC AGATTTTTAT GGCTAAAAAA GGCGGATTTT TCTTAGGNGC AGTAATTGGT

GGAACAGCAG CAGCCGTTGC CGCATTATTA CTTGCACCAA AATCAGGTAA AGAATTACGT

GATGATTTAT CAAATCAAAC AGATGATTTA AAAAACAAAG CGCAAGATTA CACAGATTAT

GCTGTTCAAA AAGGAACAGA ATTAACAGAA ATCGCAAAAC AAAAAGCCGG CGTTTTATCA

GATCAAGCCT CTGATTTGGC AGGTTCTGTC AAAGAAAAAA CAAAAGATTC ATTGGATAAA

GCACAAGGTG TTTCTGGCGA CATGCTTGAT AACTTTAAAA AACAAACAGG TGATTTATCT

GATCAATTTA AAAAAGCAGC TGACGATGCT CAAGATCACG CAGAAGATTT AGGTGAAATT

GCCGAAGATG CAGCAGAAGA TATCTATATT GACGTTAAAG ATTCTGCGGC AGCGGCCAAA

GAAACTGTTT CTGCTGGTGT CGATGAAGCA ANAGAAACCA CCAAAGATGT TCCTGAAAAA

GCTGCAGAAG CAAAAGAAGA TGTTAAAGAT GCAGCGAAAG ACGTAAAAAA AGAATTTAAA

GGGTAA

EF091-2 (SEQ ID NO:346)

MAKKG GFFLGAVIGG TAAAVAALLL APKSGKELRD DLSNQTDDLK NKAQDYTDYA

VQKGTELTEI AKQKAGVLSD QASDLAGSVK EKTKDSLDKA QGVSGDMLDN FKKQTGDLSD

QFKKAADDAQ DHAEDLGEIA EDAAEDIYID VKDSAAAAKE TVSAGVDEAX ETTKDVPEKA

AEAKEDVKDA AKDVKKEFKG

EF091-3 (SEQ ID NO:347)

AT CAAATCAAAC AGATGATTTA AAAAACAAAG CGCAAGATTA CACAGATTAT

GCTGTTCAAA AAGGAACAGA ATTAACAGAA ATCGCAAAAC AAAAAGCCGG CGTTTTATCA

GATCAAGCCT CTGATTTGGC AGGTTCTGTC AAAGAAAAAA CAAAAGATTC ATTGGATAAA

GCACAAGGTG TTTCTGGCGA CATGCTTGAT AACTTTAAAA AACAAACAGG TGATTTATCT

GATCAATTTA AAAAAGCAGC TGACGATGCT CAAGATCACG CAGAAGATTT AGGTGAAATT

GCCGAAGATG CAGCAGAAGA TATCTATATT GACGTTAAAG ATTCTGCGGC AGCGGCCAAA

GAAACTGTTT CTGCTGGTGT CGATGAAGCA ANAGAAACCA CCAAAGATGT TCCTGAAAAA

GCTGCAGAAG CAAAAGAAGA TGTTAAAGAT GCAGCGAAAG ACGTAAAAAA AGAATTTAAA

GGGTAA

EF091-4 (SEQ ID NO:348)

SNQTDDLK NKAQDYTDYA

VQKGTELTEI AKQKAGVLSD QASDLAGSVK EKTKDSLDKA QGVSGDMLDN FKKQTGDLSD

QFKKAADDAQ DHAEDLGEIA EDAAEDIYID VKDSAAAAKE TVSAGVDEAX ETTKDVPEKA

AEAKEDVKDA AKDVKKEFKG

EF092-1 (SEQ ID NO:349)

TAAGGGGATG AAGAAAAAAT GGCAAAAAAA ACAATTATGT TAGTTTGTTC CGCAGGAATG

AGCACGAGTT TATTAGTAAC AAAAATGCAA AAAGCAGCAG AAGATCGTGG CATGGAAGCA

GACATCTTTG CAGTATCGGC TTCTGAAGCA GATACAAACT TGGAAAATAA AGAGGTGAAT

GTTTTACTTT TAGGTCCACA AGTTCGTTTC ATGAAAGGGC AATTTGAACA AAAATTACAA

CCAAAAGGGA TTCCTTTAGA TGTAATTAAC ATGGCAGATT ATGGCATGAT GAATGGCGAA

AAAGTTTTAG ATCAAGCAAT CTCATTAATG GGATAA

EF092-2 (SEQ ID NO:350)

MAKKT IMLVCSAGMS TSLLVTKNQK AAEDRGMEAD TFAVSASEAD TNLENKEVNV

LLLGPQVRFM KGQFEQKLQP KGIPLDVINM ADYGMMINGEK VLDQAILSLMG

EF092-3 (SEQ ID NO:351)

AG AAGATCGTGG CATGGAAGCA

GACATCTTTG CAGTATCGGC TTCTGAAGCA GATACAAACT TGGAAAATAA AGAGGTGAAT

GTTTTACTTT TAGGTCCACA AGTTCGTTTC ATGAAAGGGC AATTTGAACA AAAATTACAA

CCAAAAGGGA TTCCTTTAGA TGTAATTAAC ATGGCAGATT ATGGCATGAT GAATGGCGAA

AAAGTTTTAG ATCAAGCAAT CTCATTAATG GGAT

EF092-4 (SEQ ID NO:352)

EDRGMEAD IFAVSASEAD TNLENKEVNV

LLLGPQVRFM KGQFEQKLQP KGIPLDVINM ADYGMMNGEK VLDQAISLMG

EF093-1 (SEQ ID NO:353)

TAGTTTTTTT CCGATAAAGG GAGAATTTTA ATGAGGCAAA AATATTCAGG AAACTTATTG

TTCACGGCCA TGGCCATTGT TTATTTGATG ACTTTTCTCG CCCTTCAGTT ACTAGAAGAA

CGTCAGTTAA CACAAAAATT TACGCAAGCT ACCCAGGAAT ACTATGCAGG GAAAAGTATC

TTTCATTTAT TTCTTGCAGA TGTTAAACAA AATAGACGAA AGTTAAAAAC AGAAGAAAGG

CTCGTATACG CGCAACTGAC COTOGATTAT ACATACAAAA ATGAACAATT AAGAATAACT

GTTTTATTAA ACAAATCTGG TCGAAAATAC CAATATCAAG AGAGAGTTTC TCATCAAAAA

AAAGCGGAAA CAATACTGGA ATAG

EF093-2 (SEQ ID NO:354)

M RQKYSGNLLF TAMAIVYLMS FLALQLLEER QLTQKFTQAT QEYYAGKSIF

HLFLADVKQN RRKLKTEERL VYAQVTLDYT YKNEQLRITV LLNKSGRKYQ YQERVSHQKK

AETILE

EF093-3 (SEQ ID NO:355)

CCTTCAGTT ACTAGAAGAA

CGTCAGTTAA CACAAAAATT TACGCAAGCT ACCCAGGAAT ACTATGCAGG GAAAAGTATC

TTTCATTTAT TTCTTGCAGA TGTTAAACAA AATAGACGAA AGTTAAAAAC AGAAGAAAGG

CTCGTATACG CGCAAGTGAC CCTCGATTAT ACATACAAAA ATGAACAATT AAGAATAACT

GTTTTATTAA ACAAATCTGG TCGAAAATAC CAATATCAAG AGAGAGTTTC TCATCAAAAA

AAAGCCGAAA CAATACTGG

EF093-4 (SEQ ID NO:356)

LQLLEER QLTQKFTQAT QEYYAGKSJIF

HLFLADVKQN RRKLKTEERL VYAQVTLDYT YKNEQLRITV LLNKSCRKYQ YQERVSHQKK

AETI

EF094-1 (SEQ ID NO:357)

TAAACATTTG AGACATTCAG AGGTGAATGT CTCTTTTTTA TTACTCAAAA ACGAAAGGGG

ATTAATTATA TGAAAAAAAC AACATTTAAA AATTGGTCGT TATTTGCGAC TTTGGCTCTA

TTAAGTCAAA CAATTGGCGG AACGATTGGT CCTACGATTG CTTTTGCCGA TGAAATTACT

CACCCTCAAG AGGTAACAAT TCATTATGAC GTAAGTAAAC TGTATGAAGT TGACGGAACT

TTTAGCGATG GCAGCACCCT CTCAGAACGT ACTACGTCAT TATATGCAGA ATACAATGGT

GCAAAACAAA CAGTATTTTG TATTGAACCA GGTGTTAGTA TTCCAACAGA AGTGACGCAC

GGTTATCAGA AAAACCCTTT GCCATCAATG TCTGATAAAG CGAAACTAGT ATCGGTTCTT

TGGGAAAAGC CTGGAACAGA TATTOATACA AATATGGTTG CACAAAAGAT GATTTGGGAA

GAAGTGAACG GTTATAAACT CCATTCCATA AAAAGATTAG GTGGTGCTTC AGTTGATATA

AAATCTATTG AAGGAAAAAT TAATAAGGCA ATTGAGGAGT ATCAXAAAAA ACCAAGTTTT

CATAATACCA CTGTAAAAAC AATTTTAGGT CAATCGACAA CTTTAATAGA TAAAAATGAA

TTAAATTTAT CTGAGTTTGA TAAAGTCGTC CAAAATACGG CGAATATAGA TTACCGTGTA

ATTCGGAATC AATTAGTGCT TACTCCAAAC TCTAATTCCA AATCAGGAAC ATTAACATTG

AAAAAATCAG CTGGTACTGG AACTCCAGTC GCTTATAAAA AAGCAGGACT TCAAACTGTG

ATGGCTGGTG CGCTTGATAA GCCCAATACC TACGCTATTA AAATTAATGT GGAAACTAAG

GGTTCTTTAA AGATCAAAAA AATCGATAAA GAATCAGGTG ATATTGTACC AGAAACGGTT

TTCCATTTAG ATTTTGGGAA AGCTTTACCT TCAAAAGATG TGACAACAGA TAAAGATGGC

ATTTCTATTT TGGATGGAAT TCCCCATGGT ACAAAGGTAA CTATTACTGA AAAATCGGTG

CCAGATCCTT ATATGATTCA TACCACACCC ATGGCTGCCA CCATTAAAGC GGGCGAGACC

ATTTCCATGA CTTCGAAAAA TATGCGACAA AAAGGTCAAA TTCTTTTAGA GAAGACTGGG

GTAGAAACAG GTACTGATCT TTGGAATGAC AATTATTCTC TAGCTGGAAA TACATTTGCC

ATTCGTAAAG ACAGCCCAGC TGGTGAAATT GTCCAAGAAA TAACAACGGA TGAAAAAGGT

CGTGCGGAAA CACCAAAAGA GCTTGCTAAT GCTTTGGAAC TGGGAACCTA TTACGTGACA

GAAACTAAAT CTAGTAATGG TTTCGTGAAT ACCTTCAAAC CAACAAAAGT CGAGTTAAAA

TATGCCAATC AAACCGTGGC TCTTGTTACC AGTAACGTAA AAGGGCAAAA CCAAGAAATT

ACTGGGGAAA CCACTTTGAC AAAAGAAGAC AAAGATACCG GTAATGAGAG TCAACGGAAA

GCTCAGTTTA AAGGAGCTGA ATATACTCTC TTTACTGCAA AAGATGGTCA AGCTGTTAAA

TGGAGTGAAG CTTTTAAAAC AGAATTAGTG AAGGGAACGA AAGCTTCTGA TGAAACAGTG

ACTTTGGCTT TAGATGAAAA GAACCAAGTT GCCGTTAAAC ACCTAGCAAT TAACGAGTAT

TTCTGGCAAG AAACCAAAGC ACCTGAAGGA TATACTTTGG ATGAAACGAA GTATCCTGTA

TCCATCAAAA AAGTTGATAA TAACGAAAAA AATGCCGTAA TTACTCGAGA TGTTACGGCA

AAAGAACAAG TTATTCGCTT TGGCTTTGAT TTCTTTAAAT TTGCTGCATC GGCTGATGGC

ACTGCCGAAA CTGGATTTAA CGACTTATCT TTTAAAGTGT CGCCATTGGA AGGGACCAAN

GAAATCACAG GTCCTGAAGA TAAAGCGACC ACAGCTTGTA ACGAGCAATT AGGTTTTGAT

GGCTATGGTA AGTTTGAAAA TCTTCCTTAT GCGGATTATT TACTTGAAGA AATAGAGGCT

CCAGAAGGAT TTCAAAAGAT TACACCACTA GAAATCCGTT CTACATTTAA GGAAAACAAA

GACGACTATG CGAAGAGTGA GTATGTCTTT ACCATTACCG AAGAAGGACA AAAACAACCA

ATTAAGATGG TGACCGTTCC TTACGAGAAA CTAACTAACA ACGAGTTTTC TGTTAGTCTG

AACCGTTTGA TGCTTTATGA TTTCCCCGAG AAAGAAGATA GTTTGACTTC TCTTGCGACT

TGGAAAGACG GAAATAAAAA ATTGAATACC CTTGATTTTA CCGACCTAGT TGATAAATTG

AGATATAACT TGCATGAAAT CAAAGAAGAC TGGTATGTCG TAGCTCAAGC CATTGATGTG

GAAGCCACAA AAGCTGCCCA AGAAAAAGAC GAAAAAGCCA AACCGGTGGT GATTGCCGAA

ACAACCGCAA CGTTGGCGAA CAAAGAGAAA ACTGGAACTT GGAAAATTCT GCATAAATTA

ACCGCTGAAC AAGTTTTGGA TAAAAGCATC GTCTTGTTCA ATTATGTGTA TGAAAACAAG

GTAGCCTTTG AAGCAGGCAA TGAGCCAGTA GCGAAGGATG CTAGCTTGAA CAATCAAGCA

CAAACCGTCA ATTGTACGAT TGAACGCCAT GTTTCCATCC AAACAAAAGC CCACCTAGAA

GATGGTTCGC AAACTTTTAC TCATGGTGAC GTGATGGATA TGTTTGATGA TGTGTCGGTT

ACCCATGATG TACTGGATGG CTCAAAAGAA GCTTTCGAAA CAATTCTGTA TGCTTTACTA

CCAGATGGTA CGAACAAAGA AATTTGGAAA TCTGGCAAAA TTGAGCATGA AGTGAATGAT

AAAGAATTTA CCAAAACCGT ACTTGCGGAA AAAGTAGATA CCGGAAAGTA TCCAGAAGGA

ACTAAGTTTA CTTTTACCGA AATCAATTAC GAAAAAGATG GAAACGTGAA TGGAAAACAC

AATGAAGATT TGAAAGAAAA ATCTCAAACC TTAACACCAA AAGAAGTGCC AACCATACCG

AGTACGCCAA AACAACCGGA AACACCAGCT GTTCCAAGTA ATTCTCAAGA ATCTAGTCCC

ACAGTGAAGA CATTCCCGCA AACTGGGGAG AAAAATTCCA ACGTTCTACT GTTAGTTGGC

TTTATCTTGA TTTTTTCGAC TGCTGGGTAT TATTTCTGGA ATCGCCGCAA TTAA

EF094-2 (SEQ ID NO:358)

MKKTTFKN WSLFATLALL SQTIGGTIGP TIAFADEITH

PQEVTIHYDV SKLYEVDGTF SDGSTLSERT TSLYAEYNGA KQTVFCIEPG VSIPTEVTHG

YQKNPLPSMS DKAKLVSVLW EKAGTDTDTN MVAQKNIWEE VNGYKLHSIK RLGGASVDIK

SIEGKINKAI EEYQKKPSFH NTTVKTILGQ STTLIDKNEL NLSEFDKVVQ NTANIDYRVI

GNQLVLTPNS NSKSGTLTLK KSAGTGTPVA YKKAGLQTVM AGALDKPNTY AIKINVETKG

SLKIKKIDKE SGDIVPETVF HLDFGKALPS KDVTTDKDGI SILDGIPHGT KVTITEKSVP

DPYMTDTTPM AATIKAGETT SMTSKNMRQK GQILLEKTGV ETGTDLWNDN YSLAGNTFAI

RKDSPAGEIV QEITTDEKGR AETPKELANA LELGTYYVTE TKSSNGFVNT FKPTKVELKY

ANQTVALVTS NVKGQNQEIT GETTLTKEDK DTGNESQGKA EFKGAEYTLF TAKDGQAVKW

SEAFKTEIVK GTKASDETVT LALDEKNQVA VKHLAINEYF WQETKAPEGY TLDETKYPVS

IKKVDNNEKN AVITRDVTAK EQVIRFGFDF FKFAGSADGT AETGFNDLSF KVSPLEGTXE

TTGAEDKATT ACNEQLGFDG YGKFENLPYG DYLLEETEAP EGEQKITPLE IRSTFKENKD

DYAKSEYVPT ITEEGQKQPI KNVTVPYEKL TNNEFSVSLN RLMLYDLPEK EDSLTSLATW

KDGNKKLNTL DFTELVDKLR YNLHEIKEDW YVVAQAIDVE ATKAAQEKDE KAKPVVIAET

TATLANKEKT GTWKILHKLT AEQVLDKSIV LFNYVYENKV AFEAGNEPVA KDASLNNQAQ

TVNCTIERHV SIQTKAHLED CSQTFTHGDV MDMFDDVSVT HDVLDGSKEA FETILYALLP

DGTNKEIWKS GKIEHEVNDK EFTKTVLAEK VDTGKYPEGT KFTFTEINYE KDGNVNGKHN

EDLKEKSQTL TPKEVPTIPS TPKQPETPAV PSNSQESSPT VKTFPQTGEK NSNVLLLVGF

ILIFSTAGYY FWNRRN

EF094-3 (SEQ ID NO:359)

CGA TGAAATTACT

CACCCTCAAG AGGTAACAAT TCATTATCAC GTAAGTAAAC TGTATGAAGT TGACGGAACT

TTTAGCGATG GCAGCACGCT CTCAGAACGT ACTACGTCAT TATATGCAGA ATACAATGGT

GCAAAACAAA CAGTATTTTG TATTGAACCA GGTGTTAGTA TTCCAACAGA AGTGACGCAC

GGTTATCAGA AAAACCCTTT GCCATCAATG TCTGATAAAG CGAAACTAGT ATCGGTTCTT

TGGGAAAAGG CTGGAACAGA TATTGATACA AATATCGTTG CACAAAAGAT GATTTGGGAA

GAAGTGAACG GTTATAAACT CCATTCCATA AAAAGATTAG GTGGTGCTTC AGTTGATATA

AAATCTATTG AAGGAAAAAT TAATAAGGCA ATTGAGGAGT ATCAAAAAAA ACCAAGTTTT

CATAATACCA CTGTAAAAAC AATTTTAGCT CAATCGACAA CTTTAATAGA TAAAAATGAA

TTAAATTTAT CTGAGTTTGA TAAAGTCGTC CAAAATACGG CGAATATAGA TTACCGTGTA

ATTGCGAATC AATTAGTGCT TACTCCAAAC TCTAATTCCA AATCAGGAAC ATTAACATTG

AAAAAATCAG CTGGTACTGG AACTCCAGTC GCTTATAAAA AAGCAGGACT TCAAACTGTG

ATGGCTGGTG CGCTTGATAA GCCCAATACC TACGCTATTA AAATTAATGT GGAAACTAAG

GGTTCTTTAA AGATCAAAAA AATCGATAAA GAATCAGGTG ATATTGTACC AGAAACGGTT

TTCCATTTAG ATTTTGGGAA AGCTTTACCT TCAAAAGATG TGACAACAGA TAAAGATGGG

ATTTCTATTT TGGATGGAAT TCCCCATGGT ACAAAGGTAA CTATTACTGA AAAATCGCTG

CCACATCCTT ATATGATTGA TACCACACCC ATCGCTGCCA CCATTAAAGC GGGCGAGACC

ATTTCCATGA CTTCGAAAAA TATGCGACAA AAACGTCAAA TTCTTTTAGA GAAGACTGGG

GTAGAAACAG GTACTGATCT TTGGAATGAC AATTATTCTC TAGCTGGAAA TACATTTGCC

ATTCGTAAAC ACAGCCCAGC TGGTGAAATT GTCCAAGAAA TAACAACGGA TGAAAAAGGT

CGTGCGGAAA CACCAAAAGA GCTTGCTAAT GCTTTGGAAC TGGGAACCTA TTACGTGACA

GAAACTAAAT CTAGTAATGG TTTCGTGAAT ACCTTCAAAC CAACAAAAGT CGAGTTAAAA

TATGCCAATC AAACCGTGGC TCTTGTTACC AGTAACGTAA AAGGGCAAAA CCAAGAAATT

ACTGGGGAAA CCACTTTGAC AAAAGAAGAC AAAGATACCG GTAATGAGAG TCAAGGGAAA

GCTCAGTTTA AAGGAGCTGA ATATACTCTC TTTACTGCAA AAGATGGTCA AGCTGTTAAA

TGGAGTGAAG CTTTTAAAAC ACAATTAGTG AAGGGAACGA AAGCTTCTGA TGAAACAG

EF094-4 (SEQ ID NO:360)

DEITH

PQEVTTHYDV SKLYEVDGTF SDGSTLSERT TSLYAEYNGA KQTVFCTEPG VSIPTEVTHC

YQKNPLPSMS DKAKLVSVLW EKAGTDIDTN MVAQKMIWEE VNGYKLHSIK RLCGASVDIK

SIEGKINKAI EEYQKKPSFH NTTVKTILGQ STTLIDKNEL NLSEEDKVVQ NTANIDYRVI

GNQLVLTPNS NSKSGTLTLK KSAGTGTPVA YKKAGLQTVM AGALDKPNTY AIKINVETKG

SLKIKKIDKE SGDIVPETVF HLDFGKALPS KDVTTDKDGI SILDGIPHGT KVTITEKSVP

DPYMTDTTPM AATIKAGETI SMTSKNMRQK GQILLEKTGV ETGTDLWNDN YSLAGNTFAT

RKDSPAGEIV QEITTDEKGR AETPKELANA LELGTYYVTE TKSSNGFVNT FKPTKVELKY

ANQTVALVTS NVKGQNQEIT GETTLTKEDK DTGNESQGKA EFKGAEYTLF TAKDGQAVKW

SEAFKTELVK GTKASDET

EF095-1 (SEQ ID NO:361)

TAAGAATTGT TGGATTGTTC TTTACAAAGA AGGGACAATA TGAAGCGAAG TAAATGGAAA

GAATTGATAG TAACGGGCAT CTGCCATATA TTAGTATTCC CCATACTAAT ACAGACAACT

GTTTTTGCAG AAACATTACC AAGTACAAAA CAAGTAACAG AAGCAACCAA TCATTCATTA

ACAGCAGAAA AAGCCGAAAG TGAACAACCA CAGACAAAGG ATAAACTACA TGATGAAGAA

ACACTGGCAT TGTCAAAAAG TGAGTTAATC CATAATGAGG CTAATGTTAC AAGTCAAACG

ATTAGAGAAA GAATTGAGAC GCCTAACCTA ACTTATCGTT ATGGATTTAT TAATGAAGAG

GGGCAGCCAG TAAACGCCAA TGAGATCCTT CTACAGTATC ATAGTTGGCA ACGCAATTCC

CCAGATGGCA TAAATGTGTG GGAAGGTGAA AGTCAACCAG TGACAGCATC TACAGTGGCT

AATTTAAAAG AAGTGGTAAT TCCAAGTGAG AAAGTAGCCG TCTATTCCGA CATGTCAACG

GTGCTTGCAG CGAGTAATCA AACATTTTTT TTACCAAGAT ATTATACTTC TTTAAGCTTA

TACAATAAGA AAGGGGAAAT TGATCCCAAT TATCCGCTGC CAACTATTTC CGACGCATCA

GGAAACCAAT ATCCAACAAC AATTTCGCAA TTTGAATTGG AAAAAATGTC TGCACAACAA

TATAGTCAGA AAACAGGAGT AACGTTTAAC ATTAGOGAGA GTCAAAAACT AATCGTTCCT

TTGTACAACC AAGTGAAGGT TGATTCATCG AATCAATCTC GGCTATTGAA TTACTTTAAA

TTTTCAGGGC CGGTTTATTA TCATGTTACC AATCGCAAAG TGACAGAACA TTTTGTGGAT

ACTCAAGGGA AACCAATCCC TCCACCACCG GGGTTTAGAC AAGGAAAGCA AACACTTATT

GAGCGTGACC CTTACACCTT TAAACAGAAA GATCTTTTGC CAAGTAGCTA TGAAATTGAC

TCAAAAACGT ATCAATTTCA AGGATGGTAT AAAGGGAAAA CGAAACCTGA AAATTTAGAA

AAAAGCGTAA CGCCCAGTTA TGATATTACC TATGACGACA ATGATGATTT AACTGTTGTC

TATAAGGAGA TACCTCAAAA AAATTATACA TTTGAGGATG TCAATGGTGT TGAAATTGCA

CCACCATCTG ATTTTATTCA GGATCACCAA CAACCAATAA CTACGGATGG CTTTCGCTAT

TTAGCTGGAA AAAAACTGCC ACAACAATAC AGCGTTAACG GTAAAACTTA TTTATATCAA

GGTTGGTATC AAGATAAAAC NAAACAAGAG AGCTTAGAAA AAACGAAGCG ACCCATAAAC

TCCCCTGTTT TTAATGAAAT GAACGCTATT ACAGCAGTGT ATAAGGAAAT AACTGCAAAA

GCTGAAATGC AAATAGAAGG ACTAGTCAAA GTCATGCCAA GTGGTTATAT ACAAATTTGG

CAGATTATGC TTACAAATGT GGGAGAAGTA CCGTTAAAAA AAATAAACTT AAAGCCAGCA

AGTGGTTGGT CACCACGTCT AGCTCGGCCA ATCCAAGTCA CGATTCGTGT TGGATCTGAA

CCAAACAAAA TTGTTCCTAT TACTGATGAA AATTGGCGAG TTGGCATTAC TTTAAATACG

GAAGTGCCTA TTGGTCAGAC AGCAACTATT ATGATGACAA CAATTGCTAC AGGTGAACCA

GATCAAGTGT TACAAGCGGC TGTTGAAATG AATGGAAATT TTTCTGCTGT TCACGCAGCT

GATACTGTCA GAATCCAACC TAAAAATCAA GAAATTGTGG CACCAGATGA GGAAGGTTTT

ATCAGCACAC CAACTTTTGA TTTTGGCAAA GTCGCCATTT CTAGCAACAC GCAGCAACAT

GGTTTAAAGC AGGOAGOAGA TTATTATGAA AATGGTCAGG AAAATCCATA TTTACGTTTG

AAAAAATCAC AACCCAATTG GGCACTAACT GCAGAACTAT CCCCCTTTGA AGGAAGAGTG

GATCAACTAT CATCAATGAC AAAGTTATTG TTAGGAACAA CCAATGTTTC AGGTTTTATT

CAGTACAATC AACCAACGGA AACTAAAGTT GCTCTTGGCA AAACAACCGC TATTCAATTA

GTTGCCAACG GTGTAGCTAG CCATATTGTT GCCAATGGTC AGTTTGACGA AAGTGATGTT

TATCAATTTG ATTTTTCTTT TGATCAAATC AAATTAGAAA TTCCAGCAAA TCAAGGTAGA

AAAGATCAAA CTTATCAAGC AATGGTGACT TGGAATTTAG TGACAGGCCC ATAA

EF095-2 (SEQ ID NO:362)

MKRSKWKE LIVTGICHIL VFPILIQTTV FAETLPSTKQ VREGTNHSLT

AEKAESEQPQ TKDKLHDEET LALSKSELID NEANVTSQTI RERIETPNLT YRYGFINEEG

QPVNANEILL QYHSWQGNSP DGINVWEGES QPVTASTVAN LKEVVIPSEK VAVYSDMSTV

LAASNQTEFL PRYYTSLSLY NKKCETDPNY PLPTTSDASG NQYPTTISQF ELEKMSAQQY

SQKTGVTFNI SESQKLIVPL YNQVKVDSSN QSGLLNYFKF SGPVYYHVTN RKVTEHFVDT

QGKPIPPPPG FRQGKQTLIE RDPYTFKQKD LLPSSYEIDS KTYQFQGWYK GKTKPENLEK

SVTPSYDITY DDNDDLTVVY KEIPQKNYTF EDVNGVEIAP PSDFIQDHQQ PITTDGFRYL

AGKKLPQQYS VNGKTYLYQG WYQDKTKQES LEKTKRPTNS PVFNEMNAIT AVYKEITAKA

EMQIEGLVKV MPSGYIQIWQ IMLTNVGEVP LKKINLKPAS CWSPGLARPI QVTIRVGSEP

NKIVPITDEN WRVGITLNTE VPEGQTATIM MTTIATGEPD QVLQAAVEMN GNFSAVHAAD

TVRTQPKNQE IVAPDEEGFI STPTFDFGKV AISSNTQQHG LKQAADYYEN GQENPYLRLK

KSQPNWALTA ELSPFEGRVD QLSSMTKLLL GTTNVSGFIQ YNQPTETKVA LGKTTAIQLV

ANGVASHTVA NGQFDESDVY QFDFSFDQIK LEIPANQORK DQTYQAMVTW NLVTGP

EF095-3 (SEQ ID NO:363)

AAGTACAAAA CAAGTAAGAG AAGGAACCAA TCATTCATTA

ACAGCAGAAA AAGCCGAAAG TGAACAACCA CAGACAAAGG ATAAACTACA TGATGAAGAA

ACACTGGCAT TGTCAAAAAG TGAGTTAATC GATAATGACG CTAATCTTAC AAGTCAAACG

ATTAGAGAAA GAATTGAGAC GCCTAACCTA ACTTATCGTT ATCGATTTAT TAATGAAGAG

GGGCAGCCAG TAAACGCCAA TGAGATCCTT CTACAGTATC ATAGTTGGCA AGGCAATTCC

CCAGATGGCA TAAATGTGTG GGAAGGTGAA AGTCAACCAG TGACAGCATC TACAGTGGCT

AATTTAAAAG AAGTGGTAAT TCCAAGTGAG AAAGTAGCCG TCTATTCCGA CATGTCAACG

GTGCTTGCAG CGAGTAATCA AACATTTTTT TTACCAACAT ATTATACTTC TTTAAGCTTA

TACAATAAGA AAGGGGAAAT TGATCCCAAT TATCCGCTGC CAACTATTTC CGACGCATCA

GGAAACCAAT ATCCAACAAC AATTTCGCAA TTTCAATTCG AAAAAATGTC TGCACAACAA

TATAGTCAGA AAACAGGAGT AACGTTTAAC ATTACCGAGA GTCAAAAACT AATCGTTCCT

TTCTACAACC AAGTCAAGGT TGATTCATCG AATCAATCTG GGCTATTGAA TTACTTTAAA

TTTTCAGCCC CGGTTTATTA TCATGTTACC AATCGCAAAG TGACACAACA TTTTGTGGAT

ACTCAAGGGA AACCAATCCC TCCACCACCG GCGTTTAGAC AAGGAAAGCA AACACTTATT

GAGCGTGACC CTTACACCTT TAAACAGAAA GATCTTTTGC CAAGTAGCTA TGAAATTGAC

TCAAAAACGT ATCAATTTCA AGGATGGTAT AXAGGGAAAA CGAAACCTGA AAATTTAGAA

AAAAGCGTAA CGCCCAGTTA TGATATTACC TATGACGACA ATGATGATTT AACTGTTGTC

TATAAGCAGA TACCTCAAAA AAATTATACA TTTGAGGATG TCAATGGTGT TGAAATTGCA

CCACCATCTG ATTTTATTCA GGATCACCAA CAACCAATAA CTACGGATCG CTTTCGCTAT

TTAGCTGGAA AAAAACTGCC ACAACAATAC AGCGTTAACG GTAAAACTTA TTTATATCAA

GCTTGGTATC AAGATAAAAC NAAACAAGAG AGCTTAGAAA AAACGAAGCG ACCCATAAAC

TCCCCTGTTT TTAATGAAAT GAACGCTATT ACAGCAGTCT ATAAGGAAAT AACTGCAAAA

GCTGAAATGC AAATAGAAGG ACTAGTCAAA GTCATGCCAA GTGGTTATAT ACAAATTTGG

CAGATTATGC TTACAAATGT GGCAGAAGTA CCGTTAAAAA AAATAAACTT AAACCCAGCA

AGTCGTTGGT CACCACOTOT ACCTCGGCCA ATCCAACTCA CCATTCGTGT TGGATCTCAA

CCAAACAAAA TTGTTCCTAT TACTGATCAA AATTGGCGAG TTGGCATTAC TTTAAATACG

GAAGTGCCTA TTGGTCAGAC ACCAACTATT ATGATGACAA CAATTGCTAC AGCTGAACCA

GATCAACTGT TACAAGCGGC TGTTGAAATG AATCGAAATT TTTCTGCTGT TCACGCAGCT

GATACTGTCA GAATCCAACC TAAAAATCAA GAAATTGTGG CACCAGATLA GGAAGGTTTT

ATCAGCACAC CAACTTTTGA TTTTGGCAAA GTCGCCATTT CTACCAACAC GCAGCAACAT

CGTTTAAACC AGOCACCAGA TTATTATGAA AATGGTCAGG AAAATCCATA TTTACGTTTG

AAAAAATCAC AACCCAATTG GGCACTAACT GCAGAACTAT CCCCCTTTGA AGGAAGAGTG

CATCAACTAT CATCAATGAC AAAGTTATTG TTAGGAACAA CCAATGTTTC AGGTTTTATT

CAGTACAATC AACCAACCGA AACTAAAGTT GCTCTTCGCA AAACAACCGC TATTCAATTA

GTTGCCAACG GTGTAGCTAG CCATATTGTT GCCAATGGTC AGTTTGACGA AAGTGATGTT

TATCAATTTG ATTTTTCTTT TGATCAAATC AAATTAGAAA TTCCAGCAAA TCAAGGTAGA

AAAGATCAAA CTTATCAAGC AATGGTGACT TGGAATTTAG TGACAGGCCC A

5F095-4 (SEQ ID NO:364)

STKQ VREGTNHSLT

AEKAESEQPQ TKDKLHDEET LALSKSELID NEANVTSQTI RERIETPNLT YRYGFINEEG

QPVNANEILL QYHSWQCNSP DGINVWEGES QPVTASTVAN LKEVVIPSEK VAVYSDMSTV

LAASNQTFFL PRYYTSLSLY NKKGETDPNY PLPTISDASG NQYPTTISQF ELEKNSAQQY

SQKTCVTFNT SESQKLIVPL YNQVKVDSSN QSGLLNYFKE SGPVYYHVTN RKVTEHFVDT

QGKPIPPPPG FRQGKQTLIE RDPYTPKQKD LLPSSYEIDS KTYQFQGWYK GKTKPENLEK

SVTPSYDITY DDNDDLTVVY KEIPQKNYTF EDVNGVEIAP PSDETQDHQQ PITTDGFRYL

AGKKLPQQYS VNGKTYLYQG WYQDKTKQES LEKTKRPINS PVFNEMNATT AVYKETTAKA

EMQIEGLVKV MPSGYIQIWQ IMLTNVGEVP LKKINLKPAS GWSPGLARPI QVTIRVGSEP

NKIVPITDEN WRVCTTLNTE VPIGQTATIM MTTIATGEPD QVLQAAVEHN GNFSAVHAAD

TVRIQPKNQE IVAPDEEGFI STPTFDFGKV AISSNTQQHG LKQAADYYEN GQENPYLRLK

KSQPNWALTA ELSPFEGRVD QLSSMTKLLL GTTNVSGFIQ YNQPTETKVA LGKTTATQLV

ANGVASHIVA NGQFDESDVY QFDFSFDQIK LEIPANQGRK DQTYQAIYTVTW NLVTCP

EF096-1 (SEQ ID NO:365)

TGAGGTGGCC AAGTTAAAAT GAAAAAATTA CAGTCACTTT TTATTGGAAT TATCGCTATT

ATTGTCATCT TGTTTTTTCG CGTGCGCCAA TTGGAGAAAG CAAGTGGCAT GGCAGGAGCA

GATACCTTGA CCATTTACAA TTGGGGGGAC TATATAGATC CGGCCTTGAT TAAGAAATTT

GAAAAAGAAA CAGCCTATAA AGTCAATTAC GAAACCTTTG ATTCTAATGA AGCTATGTAT

ACAAAAATTC AGCAAGGTGG CACAGCCTAT GATATTGCCA TTCCTTCTGA ATATATGATT

CAAAAAATGA TGAAAGCGAA GATGCTTTTA CCACTTCATC ACAGCAAATT AAAAGGCTTA

GAAAACATTG ATGCACGCTT TTTAGATCAA TCCTTTGATC CCAAAAATAA GTTTTCCGTT

CCGTACTTCT GGGGCACGTT GGGGATTATT TATAATGATA AATTTATTGA CGGCCGTCAG

ATCCAACATT GGCATGATTT ATCGCCCCCG GAATTAAAAA ATAATGTCAT GCTGATTGAT

GGCGCTCGCG AAGTGTTAGG ATTATCTTTG AACAGTTTAG GCTATTCGTT AAACAGTAAA

AACGACCAAC AATTACGTCA GGCTACCGAT AAGTTAAACC GATTAACGAA CAATGTCAAA

GCAATTGTTG CCGATGAAAT CAAAATGTAC ATGGCTAATG AAGAAAGTGC AGTTGCTGTA

ACTTTCTCTG GTGAAGCTGC TGAAATGCTA CAAAACAATG AACATCTACA TTATGTGATT

CCCAGTGAAG GCTCTAATCT CTGGTTTGAT AACATTGTGA TGCCTAAGAC AGCCAAAAAT

AAAGAGCGTG CCTATGCATT TATCAACTTT ATGTTACGAC CAGAAAATGC GGCACAAAAT

GCAGAATATA TTGGTTATTC CACACCAAAT AAAGAAGCTA AAAAACTATT ACCAAAAGAA

GTTGCCGAAG ATAAACAATT TTATCCAGAT GATGAAACTA TCAAACATTT AGAAGTTTAC

CAAGACTTAG GTCAAGAATA CTTACGAATT TATAACGATC TGTTCTTGCA GTTTAAGATG

TATCCGAAAT PA

EE096-2 (SEQ ID NO:366)

MKKLQ SLEIGITAII VILFFGVRQL EKASGMAGAD TLTIYNWGDY IDPALIKKFE

KETGYKVNYE TFDSNEAMYT KIQQGGTAYD IAIPSEYMTQ KMMKAKMLLP LDHSKLKGLE

NIDARFLDQS FDPKNKESVP YFWGTLGIIY NDKFIDGRQI QHWDDLWRPE LKNNVMLIDG

AREVLGLSLN SLGYSLNSKN DQQLRQATDK LNRLTNNVKA IVADEIK4YM ANEESAVAVT

FSGEAAEMLE NNEHLHYVTP SEGSNLWFDN IVMPKTAKNK EGAYAFHNFM LRPENAAQNA

EYIGYSTPNK EAKKLLPKEV AEDKQFYPDD ETTKHLEVYQ DLGQEYLGIY NDLFLEFKMY

RK

EF096-3 (SEQ ID NO:367)

AAGTGGCAT GCCAGGAGCA

GATACCTTGA CCATTTACAA TTGGGGGGAC TATATAGATC CGGCCTTGAT TAAGAAATTT

GAAAAAGAAA CAGGCTATAA AGTCAATTAC GAAACCTTTG ATTCTAATGA AGCTATGTAT

ACAAAAATTC AGCAAGGTGG CACAGCCTAT GATATTGCCA TTCCTTCTGA ATATATGATT

CAAAAAATGA TGAAAGCGAA GATGCTTTTA CCACTTGATC ACAGCAAATT AAAAGGCTTA

GAAAACATTG ATGCACGCTT TTTAGATCAA TCCTTTGATC CCAAAAATAA GTTTTCCGTT

CCGTACTTCT GGGGCACGTT GGGGATTATT TATAATGATA AATTTATTGA CGGCCGTCAG

ATCCAACATT GGGATGATTT ATGGCGCCCG GAATTAAAAA ATAATGTCAT GCTGATTGAT

GGCGCTCGCG AAGTGTTAGG ATTATCTTTG AACAGTTTAG GCTATTCGTT AAACAGTAAA

AACGACCAAC AATTACGTCA GGCTACCGAT AAGTTAAACC GATTAACGAA CAATGTCAAA

GCAATTGTTG CCGATGAAAT CAAAATGTAC ATGGCTAATG AAGAAAGTGC AGTTGCTGTA

ACTTTCTCTG GTGAAGCTGC TGAAATGCTA GAAAACAATG AACATCTACA TTATGTGATT

CCCAGTGAAG GCTCTAATCT CTGGTTTGAT AACATTGTGA TGCCTAAGAC AGCCAAAAAT

AAAGAGGGTG CCTATGCATT TATGAACTTT ATGTTACGAC CAGAAAATGC GGCACAAAAT

GCAGAATATA TTGGTTATTC CACACCAAAT AAAGAAGCTA AAAAACTATT ACCAAAAGAA

GTTGCCGAAG ATAAACAATT TTATCCAGAT GATGAAACTA TCAAACATTT AGAAGTTTAC

CAAGACTTAG GTCAAGAATA CTTAGGAATT TATAACGATC TGTTCTTGGA GTTTAAGATG

TATCGGAAA

EF096-4 (SEQ ID NO:368)

SGMAGAD TLTIYNWGDY IDPALIKKFE

KETGYKVNYE TFDSNEAMYT KIQQGGTAYD IAIPSEYMTQ KMMKAKNLLP LDHSKLKGLE

NIDARFLDQS FDPKNKFSVP YFWGTLGIIY NDKFIDGRQI QHWDDLWRPE LKNNVMLIDG

AREVLGLSLN SLGYSLNSKN DQQLRQATDK LNRLTNNVKA IVADEIKMYM ANEESAVAVT

FSGEAAEMLE NNEHLHYVIP SEGSNLWFDN IVMPKTAKNK EGAYAFMNFM LRPENAAQNA

EYTGYSTPNK EAKKLLPKEV AEDKQFYPDD ETIKHLEVYQ DLGQEYLGIY NDLFLEFKMY

RK

EF097-1 (SEQ ID NO:369)

TAGAAGTATT CTAATTATCT ACATAGAGAG CGAGGGACAA GGAATATGAA GGAAAAAGAA

ATGCATTCGC TCTTTTTTAA ACATAAGTTT GTGAAAGTAA CTCCCTATTT ACGTCGTTTT

GGTCATCGTT TGAGTGGGAT GATTATGCCA AATTTGAGTA TTTTTATTGC GTGGAGCTTA

TTGTCTTTGG TGGCTGGCTA TACGACTGGG AATCTACGGC TAGCTCTTTC TGAAGTCGAA

ACGATAATGA TTCGAGTTGT TTTACCGATT CTAATTGGTT TTACAGGCGG AAAAATGTTC

GAGGAACAAC GTGGCGGCGT TGTTGCTGCT ATTGCGACAG TGGGCGTGAT TGTTTCCACA

GATGTTCCAC AGTTGTTTGG TGCTATGTTT ATTGGCCCTT TAGCAGGATA TACTTTCGCC

AAAATTGAAC AAATTCTCTT ACCGAAAGTT AAAGAAGGCT ACGAGATGCT GACTAAAAAC

TTTTTAGCAG CAATTGTGGG AGGACTGCTG TGCTGTTTTG GTATTCTGGT TGTAGCTCCG

GCTGTTGAAA GCGCTAGTTT TTGGCTGTAT CAATTTTCTT CTTGGTTAAT TGAAGCCAAT

CTTTTACCAT TGGTTCACGT TTTCTTAGAG CCCTTAAAAG TGTTATTTTT TAATAATGCG

ATTAACCATG GCTTATTAAC GCCTCTAGGT TTAGAAGGTG CTAGTCAAAC AGGTCAGTCC

ATTTTATTTC TATTGGAAAC AAACCCTGGA CCAGGCGTGG GCGTTTTGGT TGCTTTTCTG

CTGTTTGGGC CTGTAGGACA ACGAAAAACA GCAGGAGGTG CCACCATGAT TCAACTGATT

GGGGGCATTC ATGAAATTTA TTTTCCGTTT GTTTTGATGG ACCCGCGCTT ATTTTTAGCA

GTAATTGCTG GAGGAATGAG TGGTACGCTT GTTTTTCAAA TATTTAATGT GGGTCTAAGT

GCTCCAGCTT CGCCAGGTTC ATTGGTTGCG ATTTTAGCCA ATGCCCCGAC TGATGCGAGG

CTGGCGGTTT TTAGCGGAAT TTTTGTTAGC TTTCTGTGCT CTTTTGCAAT AGCAAGCTTG

TTATTAAAAC GTCAACGAGG AATTGAACCA GTTTCAATGA TAAAGATGAA GGAGGAAGAC

CAAGTGGAAA CAGTCACACC TAACTATCAG CAAATTTTAT TTGTTTGTGA TGCAGGAATG

GGCTCAAGTG CCATGGGGGC TAGTTTGCTA AGCCGACAAT TAAAAGCTGT GAACTTGGAG

ATGCCTGTGA CTTACCAGTC CGTTCATCAG ATGAAGTGGC AGCCTAAGAC ATTAGTGGTC

ATTCAAGCAG AATTGAAACA GTTAGCACAA AAGTACGTCC CAGAAAAGGA TATGGTGAGT

GTTCAAAATT TTTTAGAkAT TAAATCCTAT TACCCGCAAG TTTTAGCCAA ACTGACTGCT

TCTTCTCAAG AGCAATCTTC ACTTGGTTCA GAGTCTACTG AAACGAACTC GACAAAACAA

ATACAGAAGC TTGTTTTTTT ATATGCCGAG AATGTTCGAG GATCGCAAAC AATGGGAATG

GAATTATTGC GGCAACAAGC GGCGAAACAA GGAGTCGCGA TTGAAGTATC TAAAGAGCCA

CTGGAAACAG TCTTTTTTAC CAAGGAGACA ACCTACGTAG TGACTCGTGA ACTGGCGCAA

GCCTATCATT TAGATCTAAC GCAACAAAAT TTATACGTAG TTACTAGTTT TTTGAATAAG

AAAGAGTATC AAGAATGGCT GGAAGGAGGA GCTGATAGAT GTTTTTAA

EF097-2 (SEQ ID NO:370)

MLTKNF LACIVGGLLC CFGILVVAPA

VESASFWLYQ FSSWLIEANL LPLVHVFLEP LKVLFFNNAI NHGLLTPLGL EGASQTGQSI

LFLLETNPGP GVGVLVAFLL FGPVGQRKTA GGATMIQLIG GIHEIYFPFV LMDPRLFLAV

IAGGMSGTLV FQIFNVGLSA PASPGSLVAI LANAPTDARL AVFSGIFVSF LCSFAIASLL

LKRQRGIEPV SMIKMKEEDQ VETVTPNYQQ ILFVCDAGMG SSAMGASLLS RQLKAVNLEM

PVTYQSVHQM KWQPKTLVVI QAELKQLAQK YVPEKDMVSV QNFLEIKSYY PQVLAKLTAS

SQEQSSLGSE STETNSTKQI QKLVFLYAEN VRGSQTMGME LLRQQAAKQG VAIEVSKEPL

ETVFFTKETT YVVTRELAQA YHLDLTQQNL YVVTSFLNKK EYQEWLEGGA DRCF

EF097-3 (SEQ ID NO:371)

ACGAGG AATTGAACCA GTTTCAATGA TAAAGATGAA GGAGGAAGAC

CAAGTGGAAA CAGTCACACC TAACTATCAG CAAATTTTAT TTGTTTGTGA TGCAGGAATG

GGCTCAAGTG CCATGGGGGC TAGTTTGCTA AGCCGACAAT TAAAAGCTGT GAACTTGGAG

ATGCCTGTGA CTTACCAGTC CGTTCATCAG ATGAAGTGGC AGCCTAAGAC ATTAGTGGTC

ATTCAAGCAG AATTGAAACA GTTAGCACAA AAGTACGTCC CAGAAAAGGA TATGGTGAGT

GTTCAAAATT TTTTAGAAAT TAAATCCTAT TACCCGCAAG TTTTAGCCAA ACTGACTGCT

TCTTCTCAAG AGCAATCTTC ACTTGGTTCA GAGTCTACTG AAACGAACTC GACAAAACAA

ATACAGAAGC TTGTTTTTTT ATATGCCGAG AATGTTCGAC GATCGCAAAC AATGGGAATG

GAATTATTGC GGCAACAAGC GGCGAAACAA GGAGTCGCGA TTGAAGTATC TAAAGAGCCA

CTGGAAACAG TCTTTTTTAC CAAGGAGACA ACCTACGTAG TGACTCGTGA ACTGGCGCAA

GCCTATCATT TAGATCTAAC GCAACAAAAT TTATACGTAG TTACTAGTTT TTTGAATAAG

AAAGAGTATC AAGAATGGCT GGAAGGAGGA GCTGATAGAT GTTTTT

EF097-4 (SEQ ID NO:372)

RGIEPV SMIKNKEEDQ VETVTPNYQQ ILFVCDAGMG SSAMGASLLS RQLKAVNLEM

PVTYQSVHQM KWQPKTLVVI QAELKQLAQK YVPEKDMVSV QNFLEIKSYY PQVLAKLTAS

SQEQSSLGSE STETNSTKQI QKLVFLYAEN VRGSQTMGME LLRQQAAKQG VAIEVSKEPL

ETVFFTKETT YVVTRELAQA YHLDLTQQNL YVVTSFLNKK EYQEWLEGGA DRCF

EF098-1 (SEQ ID NO:373)

TAAATGAAAA AGACAAAAGT AATGACATTG ATGGCAACCA CAACTTTAGG CGCACTGGCA

CTTGTACCAA TGAGTGCATT AGCAGTCGAC GGTGGTGAAT ACCAAACAAA CGGAGCGATT

CAATTTGCAC CAAATACGAA CCCAACGAAT CCAGTTGATC CGACGAATCC AGACCCAGAT

AAACCAATTA CACCAGTTGA TCCAACTGAT CCGACAGGGC CTAAGCCAGG GACAGCAGGT

CCGTTATCCA TTGACTATGC ATCTAGCTTA TCTTTTGGGG AACAAACGAT TACCTCAAAA

AATATGACCT ACTATGCAGA AACACAAAAA TACAAAGATA ACGCTGGTGC CGACCAAGAA

GGCCCAAACT TTGTTCAAGT CTCAGATAAT CGTGGGACTG AGACAGGTTG GACGCTAAAA

GTAAAACAAA ATCGTCAATT CAAAACTGAA GCCAACCAAG AACTAACAGC GGCCAAACTA

ACTTTAAGCA ACGGACGCGT GGTTTCAGCT TCACAATCTG CAAAGCCAAC GACAGCGCCA

GCTACGATTG AATTAAACCC AACTGGGGCT GAATCAGTGG TCATGGCTGC TGGCGATAAA

GAAGGTGCGG GTACGTACTT AATGAGCTGG GGCGATAGTG TAGATACCGC TAAAACAAGT

ATTTCATTAG AAGTACCTGG TTCAACCACA AAATATGCGA AAAAATACAC GACAACTTTT

ACTTGGACTT TGACAGATAC ACCTGCTAAC ACAGGAAACT AA

EF098-2 (SEQ ID NO:374)

MKKTKVMTLM ATTTLGALAL VPMSALAVDG GEYQTNGAIQ FAPNTNPTNP VDPTNPDPDK

PITPVDPTDP TGPKPGTAGP LSIDYASSLS FGEQTITSKN MTYYAETQKY KDNAGADQEG

PNFVQVSDNR GTETGWTLKV KQNGQFKTEA NQELTAAKVT LSNGRVVSAS QSAKPTTAPA

TIELNPTGAE SVVMAAGDKE GAGTYLMSWG DSVDTAKTSI SLEVPGSTTK YAKKYTTTFT

WTLTDTPANT GN

EF098-3 (SEQ ID NO:375)

AGTCGAC GCTGGTGAAT ACCAAACAAA CGGAGCGATT

CAATTTGCAC CAAATACGAA CCCAACGAAT CCAGTTGATC CGACGAATCC AGACCCAGAT

AAACCAATTA CACCAGTTGA TCCAACTGAT CCGACAGGGC CTAAGCCAGG GACAGCAGGT

CCGTTATCCA TTGACTATGC ATCTAGCTTA TCTTTTGGGG AACAAACGAT TACCTCAAAA

AATATGACCT ACTATOCAGA AACACAAAAA TACAAAGATA ACGCTGGTGC CGACCAAGAA

GGCCCAAACT TTGTTCAAGT CTCAGATAAT CGTGGCACTG AGACAGGTTG GACGCTAAAA

GTAAAACAAA ATGGTCAATT CAAAACTGAA GCCAACCAAG AACTAACACC GGCCAAAGTA

ACTTTAAGCA ACGGACGCGT GGTTTCAGCT TCACAATCTG CAAAGCCAAC GACAGCGCCA

GGTACCATTG AATTAAACCC AACTGGGGCT GAATCAGTGG TCATGGCTGC TGGCGATAAA

GAAGGTGCGG GTACGTACTT AATGAGCTGG GGCGATAGTG TAGATACCGC TAAAACAAGT

ATTTCATTAG AAGTACCTGG TTCAACCACA AAATATGCGA AAAAATACAC GACAACTTTT

ACTTGGACTT TGACAGATAC ACCTGCTAAC ACAGGAAACT

EF098-4 (SEQ ID NO:376)

VDG GEYQTNGAIQ FAPNTNPTNP VDPTNPDPDK

PITPVDPTDP TGPKPGTAGP LSIDYASSLS FGEQTITSKN MTYYAETQKY KDNAGADQEG

PNFVQVSDNR GTETGWTLKV KQNGQFKTEA NQELTAAKVT LSNGRVVSAS QSAKPTTAPA

TIELNPTGAE SVVMAAGDKE GAGTYLMSWG DSVDTAKTSI SLEVPGSTTK YAKKYTTTFT

WTLTDTPANT GN

EF099-1 (SEQ ID NO:377)

TGATGTTGTA GAGGGCTGAT GAAATGTTTA TCAGTCTTCT TTTTATTGAA AGGAGAGATC

ATGAAGAAAT TAGGCAAGGT TTTAATTGTT AGTTGTTTTA TTTTTATTCT TCCTTTTTTA

TTATTTTTAG GTGTATTTTC TTCTAGTGAA AGCGGAGATT CTTCCCAGTT TCAGCCCGCT

ACACCACAGG AAAAAGTAGC ATTAGAAGTT TCTAACTACG TGACGTCACA TGGCGGAACG

TTGCAGTTTG CTTCCGCTTC GATTGGCAAT ATGGAACATG AAAGTGGATT AAATCCTGCT

AGAATTCAAA GTGATTTATC GTTTAATTCA GCGATAGCTT TTAATCCTTC GTTAGGCGGT

TATGGAATTG GGTTAGGACA ATGGGATTCA GGACGAAGAG TTAATTTATT AAATTTTGCA

AAAAGTCAAA AAAAGGAATG GAAATCAGTA GCTTTACAAA TGGATTTTGC GTGGAATAAG

GATGGTTCTG ATAGTGACTT ACTTAAAAGA ATGTCTAAAT CAAAAGATGT GAATACACTT

GCGGTAGATA TTTTGAAGCT GTGGGAACGA GCTGGAACAA AAGATGATCC CGCAGAACAA

GTAAAAAGAA AGGCTAGTGC TAATAATTGG TATAAACGAC TTTCTACAGG TTCCATGGGC

GGAGGTTCAG CCAATGTTGG TCGAGGAAAA ATTGATGCCT TGGAAAAAGT GATGGGGCAA

ACTATTAATG GTGGTCAATG TTATGGCTTA TCTGCTTTTT TTGTTGAAAA ACAAGGAGGT

CTACAAATGA TGGGTACGGG GCATATGTTT GCGAGTGAAA TTGGTAATGA TTATCCTTGG

AGTTCAATTG GTTGGACAGT CATAAAGAAT CCAAATTATT CAGATATTAA AGGAGGAGAT

GTCATTAATT TTGGTCAAGG TGGTGTGGCT ACTAGTATTT ATGGGCATAC TGGTGTAGTG

GCAAGTGTTG AAGGTAAAAA CAAGTTTACT ACTTATGAGC AAAACGCTGA ACAAGGTCAA

ATTGTTGCTA AGTATTTTCG GACTTGGGGA TTAGATTTTC CACATGTGAC CAGCATAGTA

AGGAAATAG

EF099-2 (SEQ ID NO:378)

MKCLS VFFLLKGEIM KKLGKVLIVS CFIFILPFLL FLGVFSSSES GDSSQFQPAT

PQEKVALEVS NYVTSHGGTL QFASAWIGNN EHESGLNPAR IQSDLSFNSA IAFNPSLGGY

GIGLGQWDSG RRVNLLNFAK SQKKEWKSVA LQMDFAWNKD GSDSDLLKRM SKSKDVNTLA

VDILKLWERA GTKDDPAEQV KRKASANMWY KRLSTGSMGG GSANVGGGKI DALEKVMGQT

INGGQCYGLS AFFVEKQGGL QMMGTGHMFA SEIGNDYPWS SIGWTVTKNP NYSDIKAGDV

INFGQGGVAT SIYGHTGVVA SVEGKNKFTT YEQNAEQGQI VAKYFRTWGL DFPHVTSIVR

K

EF099-3 (SEQ ID NO:379)

TAGTGAA AGCGGAGATT CTTCCCAGTT TCAGCCCGCT

ACACCACAGG AAAAAGTAGC ATTAGAAGTT TCTAACTACG TGACGTCACA TGGCCGAACG

TTGCAGTTTG CTTCCGCTTG GATTGGCAAT ATGGAACATG AAAGTGGATT AAATCCTGCT

AGAATTCAAA GTGATTTATC GTTTAATTCA GCGATAGCTT TTAATCCTTC GTTAGGCGGT

TATGGAATTG GGTTAGGACA ATGGGATTCA GGACGAAGAG TTAATTTATT AAATTTTGCA

AAAAGTCAAA AAAAGGAATG GAAATCAGTA GCTTTACAAA TGGATTTTGC GTGGAATAAG

GATGGTTCTG ATAGTGACTT ACTTAAAAGA ATGTCTAAAT CAAAAGATGT GAATACACTT

GCGGTAGATA TTTTGAAGCT GTGGGAACGA GCTGGAACAA AAGATGATCC CGCAGAACAA

GTAAAAAGAA AGGCTAGTGC TAATAATTGG TATAAACGAC TTTCTACAGG TTCCATGGGC

GGAGGTTCAG CCAATGTTGG TGGAGGAAAA ATTGATGCCT TGGAAAAAGT GATGGGGCAA

ACTATTAATG GTGGTCAATG TTATGGCTTA TCTGCTTTTT TTGTTGAAAA ACAAGGAGGT

CTACAAATGA TGGGTACGGG GCATATGTTT GCGAGTGAAA TTGGTAATGA TTATCCTTGG

AGTTCAATTG GTTGGACAGT CATAAAGAAT CCAAATTATT CAGATATTAA AGCAGGAGAT

GTCATTAATT TTGGTCAAGG TGGTGTGGCT ACTAGTATTT ATGGGCATAC TGGTGTAGTG

GCAAGTGTTG AAGGTAAAAA CAAGTTTACT ACTTATGAGC AAAACGCTGA ACAAGGTCAA

ATTGTTGCTA AGTATTTTCG GACTTGGGGA TTAGATTTTC CACATGTGAC CAGCATAGTA

AGGAAAT

EF099-4 (SEQ ID NO:380)

SES GDSSQFQPAT

PQEKVALEVS NYVTSHGGTL QFASAWIGNM EHESGLNPAR IQSDLSFNSA IAFNPSLGGY

GIGLGQWDSG RRVNLLNFAK SQKKEWKSVA LQMDFAWNKD GSDSDLLKRM SKSKDVNTLA

VDILKLWERA GTKDDPAEQV KRKASANNWY KRLSTGSMGG GSANVGGGKI DALEKVMGQT

INGGQCYGLS AFFVEKQGGL QMMGTGHMFA SETGNDYPWS SIGWTVIKNP NYSDIKAGDV

INFGQGGVAT SIYGHTGVVA SVEGKNKFTT YEQNAEQGQI VAKYFRTWGL DFPHVTSIVR

K

EF100-1 (SEQ ID NO:381)

TANTTATGGC AATATGGAAG GAGTTTTATA ATGAAAAAGA AACAAAAATA CGCAGGGTTT

ACATTATTAG AAATGTTGAT TGTCTTATTG ATTATTTCCG TATTGATTTT ACTTTTTGTC

CCTAACTTAG CGAAACATAA AGAAACAGTT GATAAAAAAG GCAATGAAGC AATCGTAAAA

ATTGTAGAAT CACAAATCGA GCTCTACACA CTAGAAAAAA ATAAGACGCC TTCCTTAAAT

GAATTAGTCA ACGAAGGCTA CATTACTAAA GAGCAGTTAG ATAAATATAC AGCAGAAAAG

CAATGA

EF100-2 (SEQ ID NO:382)

MKKKQKYAGF TLLEMLIVLL IISVLILLFV PNLAKHKETV DKKGNEAIVK

IVESQIELYT LEKNKTPSLN ELVNEGYITK EQLDKYTAEK Q

EF100-3 (SEQ ID NO:383)

TAA AGAAACAGTT GATAAAAAAG GCAATGAAGC AATCGTAAAA

ATTGTAGAAT CACAAATCGA GCTCTACACA CTAGAAAAAA ATAAGACGCC TTCCTTAAAT

GAATTAGTCA ACGAAGGCTA CATTACTAAA GAGCAGTTAG ATAAATATAC AGCAGAAAAG

CAAT

EF100-4 (SEQ ID NO:384)

KETV DKKGNEAIVK

IVESQIELYT LEKNKTPSLN ELVNEGYITK EQLDKYTAEK Q

EF100-1 (SEQ ID NO:385)

TANTTATGGC AATATGGAAG GAGTTTTATA ATGAAAAAGA AACAAAAATA CGCACGGTTT

ACATTATTAG AAATGTTGAT TGTCTTATTG ATTATTTCCG TATTGATTTT ACTTTTTGTC

CCTAACTTAG CGAAACATAA AGAAACAGTT GATAAAAAAG GCAATGAAGC AATCGTAAAA

ATTGTAGAAT CACAAATCGA GCTCTACACA CTAGAAAAAA ATAAGACGCC TTCCTTAAAT

GAATTAGTCA ACGAAGGCTA CATTACTAAA GAGCAGTTAG ATAAATATAC AGCAGAAAAG

CAATGA

EF100-2 (SEQ ID NO:386)

MKKKQKYAGF TLLEMLIVLL IISVLILLFV PNLAKHKETV DKKGNEAIVK

IVESQIELYT LEKNKTPSLN ELVNEGYITK EQLDKYTAEK Q

EF100-3 (SEQ ID NO:387)

TAA AGAAACAGTT GATAAAAAAG GCAATGAAGC AATCGTAAAA

ATTGTAGAAT CACAAATCGA GCTCTACACA CTAGAAAAAA ATAAGACGCC TTCCTTAAAT

GAATTAGTCA ACGAAGGCTA CATTACTAAA GAGCAGTTAG ATAAATATAC AGCAGAAAAG

CAAT

EF100-4 (SEQ ID NO:388)

KETV DKKGNEAIVK

IVESQIELYT LEKNKTPSLN ELVNEGYITK EQLDKYTAEK Q

EF101-1 (SEQ ID NO:389)

TGAGGAGATG AAACGAAGAA AATGAAGAAG AAAACGATAA TTATATTGGG GGCAGTTGCG

GTAATTGCGG TTGGGGGCAT CGTAACTGTG AATGCGTTAA ATAAAAATGC ACAACAAGTA

GCTGTCAAGC AAGCGCCTAA AGATGACTGG GGAATTGACT ATTTTGACGT TCCCGACTTG

CAACAAATTT ATATTAACGG TGTCATCCAA CCGGAACAAA TGGAAGCCTT TGCGCGTGAT

CAAAAAATAA CAAAGGATCC AGAGATTAAG GTGAAAAACG GCGATGTCGT AGATGCAGGC

ACAGAATTAT TTACTTATGA AGATGAGGCG GTCACAAAAG AAATTGAGGC ACAACAAAAT

AGCTTAGCCA AATTAGAAAC GAAGCGGGCG AATATCTATA ATAAGTGGAA TCGGGCCATT

GATAAATTTA ATAAAACTAA AGAAGAAGAC CGCACGATGT CTGGTGATGA TTTAAATGAA

CAATATCAAA CAGAAGTCGA TGCAGTAGAT GAAGAGATTA CCTTCACCAA TGAAACCTTA

GCGGATTTAG GAGCGAAGCA ATATATTTCC ACAAAGGCTA ATTTCAAAGG TCGTGTATCA

ATTCCAGAAG TAAAAGATGC CAATTCACCG ATTTTACGGT TAACTTCAGA AGATCTTTAT

TTAGCTGGAA AAGTGAATGA AAAGGACTTG ACTAAAATTA GTGTTGGGCA AAAAGCTAAA

CTAACTTCTG TTTCCAACAA TGTGGTTGTG GATGGCTCAA TTTCTTACAT CGATGATAAT

CCTCCTGAAG GCAACAGCGA TGCCGCGAGT CGCAATCCAG AGGGCGGCAC AACGATGTCT

AGTTATAGCG TCAAAATTGC GTTGGCCAAT TTAGACAAAG TCAAAAATGG CTACCATATG

CAAGCAACCA TTGATTTAGG CGATTTAGGG GCGATTGAGT TACCGAAAAA AGCGATTCAA

AAAGAGGGTG AACAGGCCTA CCTTTTAGTG AATGATTTTG GAACCATCAT TCGTCGTGAT

GTCCAAGTCG GGCAAGAAAA TGGCGACAAA ATGGCGATTG AATCTGGCTT AGAATCAGCC

GACCGAGTGG TTATTTCTTC AAAAAAACCA GTAAAAGTCG GTGATATTGT TGAATCAGAT

GCAGCGATTG CTTCTGATGA ATCAGCAACC AACGAATCAA TGACAGATGC GTCGAAATAG

EF101-2 (SEQ ID NO:390)

MKKK TITILGAVAV IAVGGIVTVN ALNKNAQQVA VKQAPKDDWG IDYFDVPDLQ

QIYINGVIQP EQMEAFARDQ KITKDPEIKV KNGDVVDAGT ELFTYEDEAV TKEIEAQQNS

LAKLETKRAN IYNKWNRAID KFNKTKEEDR TMSGDDLNEQ YQTEVDAVDE ETTETNETLA

DLGAKQYIST KANFKGRVSI PEVKDANSPI LRLTSEDLYL AGKVNEKDLT KISVGQKAKL

TSVSNNVVVD GSTSYIDDNP PEGNSDAASG NPEGGTTMSS YSVKIALANL DKVKNGYHMQ

ATIDLCDLGA IELPKKAIQK EGEQAYVLVN DFGTIIRRDV QVGQENGDKM AIESGLESAD

RVVISSKKPV KVGDIVESDA AIASDESATN ESMTDASK

EF101-3 (SEQ ID NO:391)

TAAAAATGC ACAACAAGTA

GCTGTCAAGC AAGCGCCTAA AGATGACTGG GGAATTGACT ATTTTGACGT TCCCGACTTG

CAACAAATTT ATATTAACGG TGTCATCCAA CCGGAACAAA TGGAAGCCTT TGCGCGTCAT

CAAAAAATAA CAAAGGATCC AGAGATTAAG GTGAAAAACG GCGATGTCGT AGATGCAGGC

ACAGAATTAT TTACTTATGA AGATGAGGCG GTCACAAAAG AAATTGAGGC ACAACAAAAT

AGCTTAGCCA AATTAGAAAC GAAGCGGGCG AATATCTATA ATAAGTGCAA TCGGGCCATT

GATAAATTTA ATAAAACTAA AGAAGAAGAC CGCACGATGT CTGGTGATGA TTTAAATGAA

CAATATCAAA CAGAAGTCGA TGCAGTAGAT GAAGAGATTA CCTTCACCAA TGAAACCTTA

GCGGATTTAG GAGCGAAGCA ATATATTTCC ACAAAGGCTA ATTTCAAAGG TCGTGTATCA

ATTCCAGAAG TAAAAGATGC CAATTCACCG ATTTTACGGT TAACTTCAGA AGATCTTTAT

TTAGCTGGAA AAGTGAATGA AAAGGACTTG ACTAAAATTA GTGTTGGGCA AAAAGCTAAA

CTAACTTCTG TTTCCAACAA TGTGGTTGTG GATGGCTCAA TTTCTTACAT CGATGATAAT

CCTCCTGAAG GCAACAGCGA TGCCGCGAGT GGCAATCCAG AGGGCGGCAC AACGATGTCT

AGTTATAGCG TCAAAATTGC GTTGGCCAAT TTAGACAAAG TCAAAAATGG CTACCATATG

CAAGCAACCA TTGATTTAGG CGATTTAGGG GCGATTGAGT TACCGAAAAA AGCGATTCAA

AAAGAGGGTG AACAGGCCTA CGTTTTAGTG AATGATTTTG GAACCATCAT TCGTCGTGAT

GTCCAAGTCG GGCAAGAAAA TGGCGACAAA ATGGCGATTG AATCTGGCTT AGAATCAGCC

GACCCAGTGG TTATTTCTTC AAAAAAACCA GTAAAAGTCG GTGATATTGT TGAATCAGAT

GCAGCGATTG CTTCTGATGA ATCAGCAACC AACGAATCAA TGACAGATGC GTCGAAAT

EF101-4 (SEQ ID NO:392)

KNAQQVA VKQAPKDDWG IDYFDVPDLQ

QIYINGVIQP EQMEAFARDQ KITKDPEIKV KNGDVVDAGT ELFTYEDEAV TKEIEAQQNS

LAKLETKRAN IYNKWNRAID KFNKTKEEDR TMSGDDLNEQ YQTEVDAVDE EITFTNETLA

DLGAKQYIST KANFKGRVSI PEVKDANSPI LRLTSEDLYL AGKVNEKDLT KISVGQKAKL

TSVSNNVVVD GSISYIDDNP PEGNSDAASG NPEGGTTMSS YSVKIALANL DKVKNGYHMQ

ATIDLGDLGA IELPKKAIQK EGEQAYVLVN DFGTIIRRDV QVGQENGDKM AIESGLESAD

RVVISSKKPV KVGDIVESDA AIASDESATN ESMTDASK

EF102-1 (SEQ ID NO:393)

TAAACATTTG AGACATTCAG AGGTGAATGT CTCTTTTTTA TTACTCAAAA ACGAAAGGGG

ATTAATTATA TGAAAAAAAC AACATTTAAA AATTGGTCGT TATTTGCGAC TTTGGCTCTA

TTAAGTCAAA CAATTGGCGG AACGATTGGT CCTACGATTG CTTTTGCCGA TGAAATTACT

CACCCTCAAG AGCTAACAAT TCATTATGAC GTAAGTAAAC TGTATGAAGT TGACGGAACT

TTTAGCGATG GCAGCACGCT CTCAGAACGT ACTACGTCAT TATATGCAGA ATACAATGGT

GCAAAACAAA CAGTATTTTG TATTGAACCA CGTGTTAGTA TTCCAACAGA AGTGACGCAC

GGTTATCAGA AAAACCCTTT GCCATCAATG TCTCATAAAG CGAAACTAGT ATCGGTTCTT

TGGGAAAAGG CTGGAACAGA TATTGATACA AATATGGTTG CACAAAAGAT GATTTGGGAA

GAAGTGAACG GTTATAAACT CCATTCCATA AAAAGATTAG GTGGTGCTTC AGTTGATATA

AAATCTATTG AAGGAAAAAT TAATAAGGCA ATTGAGGAGT ATCAAAAAAA ACCAAGTTTT

CATAATACCA CTGTAAAAAC AATTTTAGGT CAATCGACAA CTTTAATAGA TAAAAATGAA

TTAAATTTAT CTGAGTTTGA TAAAGTCGTC CAAAATACGG CGAATATAGA TTACCGTGTA

ATTGGGAATC AATTAGTGCT TACTCCAAAC TCTAATTCCA AATCAGGAAC ATTAACATTG

AAAAAATCAG CTGOTACTGG AACTCCAGTC GCTTATAAAA AAGCAGGACT TCAAACTGTG

ATGGCTGGTG CGCTTGATAA GCCCAATACC TACGCTATTA AAATTAATGT GGAAACTAAG

GGTTCTTTAA AGATCAAAAA AATCGATAAA GAATCAGCTG ATATTGTACC AGAPACGGTT

TTCCATTTAG ATTTTGGGAA AGCTTTACCT TCAAAAGATG TGACAACAGA TAAAGATGGG

ATTTCTATTT TGGATCGAAT TCCCCATGGT ACAAAGGTAA CTATTACTGA AAAATCGGTG

CCAGATCCTT ATATGATTGA TACCACACCC ATGGCTGCCA CCATTAAAGC GGGCGAGACC

ATTTCCATGA CTTCGAAAAA TATGCGACAA AAAGGTCAAA TTCTTTTAGA GAAGACTGGG

GTAGAAACAG GTACTGATCT TTGGAATGAC AATTATTCTC TAGCTGGAAA TACATTTGCC

ATTCGTAAAG ACAGCCCAGC TGGTCAAATT GTCCAAGAAA TAACAACGGA TGAAAAAGGT

CGTGCGGAAA CACCAAAAGA GCTTGCTAAT GCTTTGGAAC TGGGAACCTA TTACGTGACA

GAAACTAAAT CTAGTAATGG TTTCGTGAAT ACCTTCAAAC CAACAAAAGT CGAGTTAAAA

TATGCCAATC AAACCGTGGC TCTTGTTACC AGTAACGTAA AAGGGCAAAA CCAAGAAATT

ACTGGGGAAA CCACTTTGAC AAAAGAAGAC AAAGATACCG GTAATGAGAG TCAAGGGAAA

GCTGAGTTTA AAGGACCTGA ATATACTCTC TTTACTGCAA AAGATGGTCA AGCTGTTAAA

TGGAGTGAAG CTTTTAAAAC AGAATTAGTG AAGGGAACGA AAGCTTCTGA TGAAACAGTG

ACTTTGGCTT TAGATGAAAA GAACCAAGTT CCCGTTAAAC ACCTAGCAAT TAACGAGTAT

TTCTGGCAAG AAACCAAAGC ACCTGAAGGA TATACTTTGG ATGAAACGAA GTATCCTGTA

TCCATCAAAA AAGTTGATAA TAACGAAAAA AATGCCGTAA TTACTCGAGA TGTTACGGCA

AAAGAACAAG TTATTCGCTT TGGCTTTGAT TTCTTTAAAT TTGCTGGATC GGCTGATGGC

ACTGCCGAAA CTGGATTTAA CGACTTATCT TTTAAAGTGT CGCCATTGGA AGGGACCAAN

GAAATCACAG GTGCTGAAGA TAAAGCGACC ACAGCTTGTA ACGAGCAATT AGGTTTTGAT

GGCTATGGTA AGTTTGAAAA TCTTCCTTAT GGGGATTATT TACTTGAAGA AATAGAGGCT

CCAGAAGGAT TTCAAAAGAT TACACCACTA GAAATCCGTT CTACATTTAA GGAAAACAAA

GACGACTATG CGAAGAGTGA GTATGTCTTT ACCATTACCG AAGAAGCACA AAAACAACCA

ATTAAGATGG TGACCGTTCC TTACGAGAAA CTAACTAACA ACGAGTTTTC TGTTAGTCTG

AACCGTTTGA TGCTTTATGA TTTGCCCGAG AAAGAAGATA GTTTGACTTC TCTTGCGACT

TGGAAAGACG GAAATAAAAA ATTGAATACC CTTGATTTTA CCGAGCTAGT TGATAAATTG

AGATATAACT TGCATGAAAT CAAAGAAGAC TGGTATGTCG TAGCTCAAGC CATTGATGTG

GAAGCCACAA AAGCTGCCCA AGAAAAAGAC GAAAAAGCCA AACCGGTGGT GATTGCCGAA

ACAACCGCAA CGTTGGCGAA CAAAGAGAAA ACTGGAACTT CGAAAATTCT GCATAAATTA

ACCGCTGAAC AAGTTTTGGA TAAAAGCATC GTCTTGTTCA ATTATGTGTA TGAAAACAAG

GTAGCCTTTG AAGCAGGCAA TGAGCCAGTA GCGAAGGATG CTAGCTTGAA CAATCAAGCA

CAAACCGTCA ATTGTACGAT TGAACGCCAT GTTTCCATCC AAACAAAAGC CCACCTAGAA

GATGGTTCGC AAACTTTTAC TCATGGTGAC GTGATGGATA TGTTTGATGA TGTGTCGGTT

ACCCATGATG TACTGGATGG CTCAAAAGAA GCTTTCGAAA CAATTCTGTA TGCTTTACTA

CCAGATGGTA CGAACAAAGA AATTTGGAAA TCTGGCAAAA TTGAGCATGA AGTGAATGAT

AAAGAATTTA CCAAAACCGT ACTTGCGGAA AAAGTAGATA CCGGAAAGTA TCCAGAAGGA

ACTAAGTTTA CTTTTACGGA AATCAATTAC GAAAAAGATG GAAACGTGAA TGGAAAACAC

AATGAAGATT TGAAAGAAAA ATCTCAAACC TTAACACCAA AAGAAGTGCC AACCATACCG

AGTACGCCAA AACAACCGGA AACACCAGCT GTTCCAAGTA ATTCTCAAGA ATCTAGTCCC

ACAGTGAAGA CATTCCCGCA AACTGGGGAG AAAAATTCCA ACGTTCTACT CTTAGTTGGC

TTTATCTTGA TTTTTTCCAC TGCTGGGTAT TATTTCTGGA ATCGCCGCAA TTAA

EF102-2 (SEQ ID NO:394)

MKKTTFKN WSLFATLALL SQTIGGTTGP TIAFADEITH

PQEVTIHYDV SKLYEVDGTF SDGSTLSSRT TSLYAEYNGA KQTVFCIEPG VSIPTEVTHG

YQKNPLPSMS DKAKLVSVLW EKAGTDIDTN MVAQKMIWEE VNGYKLHSIK RLGGASVDTK

SIEGKINKAI EEYQKKPSFH NTTVKTILGQ STTLIDKNEL NLSEFDKVVQ NTANIDYRVI

GNQLVLTPNS NSKSGTLTLK KSAGTGTPVA YKKAGLQTVM AGALDKPNTY AIKTNVSTKG

SLKTKKIDKE SGDIVPETVF HLDFGKALPS KDVTTDKDGT SILDGIPHGT KVTITEKSVP

DPYMIDTTPM AATTKAGETI SMTSKNNRQK CQILLEKTGV ETCTDLWNDN YSLAGNTFAI

RKDSPACETV QEITTDEKGR AETPKELANA LELGTYYVTE TKSSNGFVNT FKPTKVELKY

ANQTVALVTS NVKGQNQEIT GETTLTKEDK DTGNESQGKA EFKGAEYTLF TAKDGQAVKW

SEAFKTELVK GTKASDETVT LALDEKNQVA VKHLAINEYF WQETKAPEGY TLDETKYPVS

IKKVDNNEKN AVITRDVTAK EQVIRFGFDF FKFAGSADGT AETGFNDLSF KVSPLEGTXE

ITGAEDKATT ACNEQLGFDG YGKFENLPYG DYLLEEIEAP EGPQKITPLE IRSTFKENKD

DYAKSEYVFT ITEEGQKQPI KMVTVPYEKL TNNEFSVSLN RLMLYDLPEK EDSLTSLATW

KDGNKKLNTL DFTELVDKLR YNLHETKEDW YVVAQAIDVE ATKAAQEKDE KAKPVVIAET

TATLANKEKT GTWKILHKLT AEQVLDKSIV LFNYVYENKV AFEAGNEPVA KDASLNNQAQ

TVNCTIERHV STQTKAHLED GSQTFTHGDV MDMFDDVSVT HDVLDGSKEA FETILYALLP

DGTNKEIWKS GKIEHEVNDK EFTKTVLAEK VDTGKYPEGT KFTFTEINYE KDGNVNGKHN

EDLKEKSQTL TPKEVPTIPS TPKQPETPAV PSNSQESSPT VKTFPQTGEK NSNVLLLVGF

ILIFSTAGYY FWNRRN

EF102-3 (SEQ ID NO:395)

TT TAGATGAAAA GAACCAAGTT GCCGTTAAAC ACCTAGCAAT TAACGAGTAT

TTCTGGCAAG AAACCAAAGC ACCTGAACGA TATACTTTGG ATGAAACGAA GTATCCTGTA

TCCATCAAAA AAGTTGATAA TAACGAAAAA AATGCCGTAA TTACTCGACA TCTTACGGCA

AAAGAACAAG TTATTCGCTT TGGCTTTGAT TTCTTTAAAT TTGCTGGATC GGCTGATGGC

ACTGCCGAAA CTGGATTTAA CGACTTATCT TTTAAAGTGT CGCCATTGGA AGGGACCAAN

GAAATCACAG GTGCTGAAGA TAAAGCGACC ACAGCTTGTA ACGAGCAATT AGGTTTTCAT

GGCTATGGTA AGTTTGAAAA TCTTCCTTAT GGGGATTATT TACTTGAACA AATAGAGGCT

CCACAAGGAT TTCAAAAGAT TACACCACTA GAAATCCGTT CTACATTTAA GGAAAACAAA

GACGACTATG CGAAGACTGA CTATGTCTTT ACCATTACCG AAGAAGGACA AAAACAACCA

ATTAAGATCG TGACCGTTCC TTACGACAAA CTAACTAACA ACGAGTTTTC TGTTACTCTG

AACCGTTTGA TGCTTTATGA TTTGCCCGAC AAAGAAGATA GTTTGACTTC TCTTGCGACT

TGGAAAGACG GAAATAAAAA ATTGAATACC CTTGATTTTA CCGAGCTAGT TCATAAATTC

AGATATAACT TGCATGAAAT CAAAGAAGAC TGGTATGTCC TAGCTCAAGC CATTGATGTG

GAAGCCACAA AAGCTGCCCA AGAAAAACAC GAAAAAGCCA AACCGGTGGT GATTCCCCAA

ACAACCGCAA CCTTGGCGAA CAAAGAGAAA ACTGGAACTT GGAAAATTCT GCATAAATTA

ACCGCTGAAC AAGTTTTGGA TAAAAGCATC GTCTTGTTCA ATTATGTGTA TGAAAACAAG

CTAGCCTTTC AAGCAGGCAA TGAGCCACTA GCGAACGATG CTAGCTTGAA CAATCAAGCA

CAAACCGTCA ATTGTACGAT TGAACGCCAT GTTTCCATCC AAACAAAAGC CCACCTACAA

GATGGTTCCC AAACTTTTAC TCATGGTGAC GTGATCGATA TGTTTGATGA TGTGTCCCTT

ACCCATGATG TACTGGATGG CTCAAAACAA GCTTTCGAAA CAATTCTGTA TGCTTTACTA

CCAGATGGTA CGAACAAAGA AATTTGGAAA TCTCGCAAAA TTGAGCATGA AGTGAATGAT

AAAGAATTTA CCAAAACCGT ACTTGCGGAA AAACTACATA CCGCAAAGTA TCCAGAAGGA

ACTAAGTTTA CTTTTACGGA AATCAATTAC GAAAAAGATG GAAACGTGAA TGGAAAACAC

AATGAAGATT TGAAAGAAAA ATCTCAAACC TTAACACCAA AAGAAGTGCC AACCATACCG

AGTACCCCAA AACAACCGGA AACACCAGCT GTTCCAAGTA ATTCTCAAGA ATCTAGTCCC

ACAGTGAACA

EF102-4 (SEQ ID NO:396)

LDEKNQVA VKHLAINEYF WQETKAPEGY TLDETKYPVS

IKKVDNNEKN AVITRDVTAK EQVIRFGFDF FKFACSADCT AETGFNDLSF KVSPLEGTXE

ITGAEDKATT ACNEQLGFDC YGKFENLPYG DYLLEETEAP ECFQKITPLE IRSTFKENKD

DYAKSEYVFT ITEEGQKQPT KMVTVPYEKL TNNEFSVSLN RLMLYDLPEK EDSLTSLATW

KDGNKKLNTL DFTELVDKLR YNLHEIKEDW YVVAQATDVE ATKAAQEKDE KAKPVVIAET

TATLANKEKT GTWKILHKLT AEQVLDKSIV LFNYVYENKV AFEAGNEPVA KDASLNNQAQ

TVNCTIERHV SIQTKAHLED GSQTFTHGDV MDMFDDVSVT HDVLDCSKEA FETILYALLP

DGTNKEIWKS GKIEHEVNDK EFTKTVLAEK VDTGKYPEGT KFTFTEINYE KDGNVNGKHN

EDLKEKSQTL TPKEVPTIPS TPKQPETPAV PSNSQESSPT VK

EF103-1 (SEQ ID NO:397)

TAAGATAGGT TTATCAAAGA AAAGGAGCGA TGCTTTATGA AAAAGAAAGT ATTAAGTTCG

ATTACTTTAG TAACATTAAG TACGTTACTT ATAGCAGGTT ATGCAAGTCC AGCATTTGCA

GATCATGCAG CCAATCCAAA TAGTGCTACA GCAAATTTAG GCAAACATCA AAACAATGGC

CAAACAAGAG GCGACAAGGC GACTAAGATT TTATCTGGCA CGGACTGGCA AGGAACCCGT

GTTTATGATG CTGCTGGTAA TGATTTAACG GCAGAAAATG CTAATTTTAT TGGTTTAGCA

AAATATGATG GTGAAACCGG TTTTTACGAG TTTTTCGACA AAAATACTGG GGAAACCCGT

GGTGACGAAG GAACATTTTT TGTGACAGGT GATGGCACAA AACGAATTTT AATTTCGCGG

ACACAAAATT ATCAAGCCGT ACTGGATTTA ACCGAAGTGA GTAAAGACNA ATTTACTTAC

AAGCGTTTAG GGAAAGATAA ACTGGGGAAT GATGTTGAAG TTTACGTGGA ACACATCCCT

TATCATGGGA AAAAATTAGC TTTTACAAAT GGACGTGAAG CATTAACCAA TCAAACTGGC

AAAATTGTGA CAAATAAATC AGGGGATAAA ATTTTAGGAA CAACCTTGTG GAATGGCACA

AAAGTCGTAG ATAAAAACGG TAATGATGTG ACAGCGGCCA ATCAAAATTT CATTAGTTTA

GCGAAATTTG ATCCAAACAC AAGTAAATAT GAATTTTTCA ATTTACAAAC AGGTGAAACC

CGCGGCGACT TTGGGTACTT CCAAGTGGTG GACAATAACA AGATTCGGGC CCATGTATCT

ATTGGTACGA ATCGTTACGG CGCGGCCCTA GAATTAACGG AACTAAACAA TGATCGATTT

ACGTATACTC GAATGGGTAA AGATAATGCT GGTAATGATA TTCAAGTGTT CGTGGAACAT

GAACCTTACC AAGGCACATA TCATCCAGCC TTTACTTTCT AA

EF103-2 (SEQ ID NO:398)

MKKKVLSSI TLVTLSTLLI AGYASPAFAD HAANPNSATA NLGKHQNNGQ

TRGDKATKIL SGTDWQGTRV YDAAGNDLTA ENANFIGLAK YDGETGFYEF FDKNTGETRG

DEGTFFVTGD GTKRILISRT QNYQAVVDLT EVSKDXFTYK RLGKDKLGND VEVYVEHIPY

HGKKLAFTNG REALTNQTGK IVTNKSGDKI LGTTLWNGTK VVDKNGNDVT AANQNFISLA

KFDPNTSKYE FFNLQTGETR GDFGYFQVVD NNKIRAHVSI GTNRYGAALE LTELNNDRFT

YTRMGKDNAG NDIQVFVEHE PYQGTYHPAF TF

EF103-3 (SEQ ID NO:399)

TCATGCAG CCAATCCAAA TAGTGCTACA GCAAATTTAG GCAAACATCA AAACAATGGC

CAAACAAGAG GCGACAAGGC GACTAAGATT TTATCTGGCA CGGACTGGCA AGGAACCCGT

GTTTATGATG CTGCTGGTAA TGATTTAACG GCAGAAAATG CTAATTTTAT TGGTTTAGCA

AAATATGATG GTGAAACCGG TTTTTACGAG TTTTTCGACA AAAATACTGG GGAAACCCGT

GGTGACGAAG GAACATTTTT TGTGACAGGT GATGGCACAA AACGAATTTT AATTTCGCGG

ACACAAAATT ATCAAGCCGT AGTGGATTTA ACCGAAGTGA GTAAAGACNA ATTTACTTAC

AAGCGTTTAG GGAAAGATAA ACTGGGGAAT GATGTTGAAG TTTACGTGGA ACACATCCCT

TATCATGGGA AAAAATTAGC TTTTACAAAT GGACGTGAAG CATTAACCAA TCAAACTGGC

AAAATTGTGA CAAATAAATC AGGGGATAAA ATTTTAGGAA CAACCTTGTG GAATGGCACA

AAAGTCGTAG ATAAAAACGG TAATGATGTG ACAGCGGCCA ATCAAAATTT CATTAGTTTA

GCGAAATTTG ATCCAAACAC AAGTAAATAT GAATTTTTCA ATTTACAAAC AGGTGAAACC

CGCGGCGACT TTGGGTACTT CCAAGTGGTG GACAATAACA AGATTCGGGC CCATGTATCT

ATTGGTACGA ATCGTTACGG CGCGGCGCTA GAATTAACGG AACTAAACAA TGATCGATTT

ACGTATACTC GAATGGGTAA AGATAATGCT GGTAATGATA TTCAAGTGTT CGTGGAACAT

GAACCTTACC AAGGCACATA TCATCCAGCC T

EF103-4 (SEQ ID NO:400)

HAANPNSATA NLGKHQNNGQ

TRGDKATKIL SGTDWQGTRV YDAAGNDLTA ENANFIGLAK YDGETGFYEF FDKNTGETRG

DEGTFFVTGD GTKRILISRT QNYQAVVDLT EVSKDXFTYK RLGKDKLGND VEVYVEHIPY

HGKKLAFTNC REALTNQTGK TVTNKSGDKI LGTTLWNGTK VVDKNGNDVT AANQNFISLA

KFDPNTSKYE FFNLQTGETR CDFGYFQVVD NNKIRAHVSI GTNRYCAALE LTELNNDRFT

YTRMGKDNAG NDIQVFVEHE PYQGTYHPA

EF104-1 (SEQ ID NO:401)

TGAAAGGGGA TTAGTATGAA GAAAAAAACT TTTTCTTTTG TGATGTTGAG TATACTTCTC

GCACAAAATT TCGGGTTTGC CGTAAATGCC TATGCTGTAA CAACGACAGA AGCACAAACA

GAGACCACTG ATACAGCAAA AAAAGAGGCA GAGTTATCGA ACTCAACACC ATCTTTACCT

TTAGCAACAA CGACTACTTC AGAAATGAAT CAACCAACTG CAACAACTGA ATCGCAAACC

ACAGAGGCGA GCACAACAGC TTCCAGTGAT GCTGCTACAC CATCTGAACA ACAAACAACG

GAGGACAAGG ACACCTCACT TAATGAAAAA GCCCTGCCAG ATGTTCAAGC GCCAATTACA

GATGAACTAC TTGACAGTAT GAGTCTTGCG CCGATTGGTG GAACAGAATA CAGCCAAACA

GAGGTTCACC GCGAATTAAA TACAACACCG GTAACCGCTA CGTTCCAATT TGCTGTTGGA

AACACAGGTT ATGCACCTGG ATCAGTTTAT ACAGTTCAAT TACCAGAACA TTTAGGTTAT

TCAACTGTCA GCGGAGAAGT GACAGGCATT GGCGCAACTT GGGCAGTCGA TGCGGCGACC

AAAACATTAA GTATTACGTT TAATCAACGA GTTTCAGATA CTTCCTTTAA AGTAGAACTA

AAAAGTTATC TAACAACAGA GGCGGAACCA TTAATCAAAA TTGAAACTCC AGGAAAAAAT

AAAAAAACCT ACTCGTTTGA TTTATATGAA CAAGTGGAAC CAATTCAATA TAACGAACGA

ACCAGAACGA CGGGGTTAGA TGGCGAAATT TTTTATAATT TAGACCGGAC GTTAACTGGC

AATCAAACAT TAGAATTATT AACAACAGAG ACGCCAGGCG CTGTCTTTGG AAAACAAGAT

AACTTGGAAC CTCAAGTTTT CAGTTACGAT GTCGACATTA ATGGTCAAAT TTTACCAGAA

ACGCAAACCT TGTTAACACC TGGCAAAGAT TATACATTAA GCGATAATTC ACTCGGGCGG

ATTGCTGTAA CTGTTCCAAA CATCAATCAA CAAAAAGCCT ATTCCTTATC GATTAATCGG

ACAATTTATT TAGAGAGTGC TTCGGACTAT AACTACTTAT ATTCGCAGCA GTATCCAACA

ACAAAAATTG GCTCAATTTC TTTGAAAAGT ACGACAGGAA CTAAACAAAC AACCGATTTT

ACTGCTAAGA CGAGTCAAAC AAGTAAAGTA ATTGCTGATC GTGAAATGCG TAGTATGTCC

TATATCAGTT TTCAAAGCAA AGGGAAATAT TATGTAACAA TTTATGGCAC GTTAACAGAA

ACAAAAGTGG GTCAACAAAT COTATTAGAG AGTACAAACG GTCAAGAAAT TAAGAATCCT

AAATTTACGG CGTATGGTCC TTTATATGAA AATGTAAAAT TGGAAGACTA TTTTGATATT

AAAACTGAAG GTGGCAAGCT CACTTTAACG GCCACAAAAG ATAGCTATTT AAGAATAAAT

ATTTCTGATT TAACAATGGA TTTTGACAAG AAGGACATTA ATCTATCATT AAGTACACCT

GTAATTGGTC CTAATAAAGC CATTCAATTA GTATCCGATC AATATATTGA ACCAATTAGT

GTTGTTAATC CTTTGAATGC TGAAACTGCT TGGGGTAATT ATGATCAAAA TGGTGCCTAT

TCATCAAGAA CAACTGTCTC AGTTATGGGA AGCAAAGAGA AACCGATTCA AAATTTAGAA

ATTAAAGTAA AGCATCCTAA TTATCTTTCA TTACGAGCTA CAAAAGAAAT TTATTTTTAT

TACAAGTTAG GAACGGATTA TACAGTAACG CCAACGTCAG ATGGTTCAGT TATTAAGTTC

ACTACGCCAA TAACCAACGA AATCCAAATT CCAATTGGTT TTAATTATGT GCCAGATAGT

TTGCCAAAAG ATAAAAGTAT CCCAGTCGAT ACGATACCGA TAACAATGAG TGCTGAAGGT

TTAACTCCAG TTGATACGAC AGTAACTACT AATAGTAAGC GTGGTTCTGA ACGAACACTT

CAAAGTAGTA AAAATCAATT CCTTGTCAAT GCACGAAATG ATTCTTTTGA CTCACTAAGC

GTCCGTACAA AAATTCCAGC TGGCGCCGAT GTTCTTTTTG ACATTTATGA TGTTTCAAAC

GATCAGGTAG ATTCAATTTA TCCACAATAC TGGGACCGCG GTCAATACTT TGATAAACCA

ATGACGCCAA ACAGCCCTGG ATATCCAACG ATTACTTTTG ACGAAAATAC CAATAGTTAC

ACGTTTGATT TTGGAAAAAC CAACAAACGT TACATTATTG AGTATAAAAA CGCCAATGGC

TGGATCGACG TGCCAACTCT TTATATAACA GGGACAGCGA AAGAACCACA ATCGAATAAT

AATGAAGGCT CTGCTTCGGT TTCTGTTCAA AATGAAGCGT TAGACATTTT GAGTGCAACA

CAAGCGGCGA ATCCAACATT AAAAAATGTA ACAAAAACGA CAGTAACAAC AAAAAATATT

GATAATAAAA CACATCGTGT GAAAAATCCA ACGATTGAAT TAACACCAAA AGGCACAACC

AATGCTCAAA TCGATTTGAA TTCTATTACC GTGAAAGGCG TGCCAGAAGA TGCTTATTCA

TTAGAGAAGA CTACAAACGG TGCGAAAGTC ATTTTTAAAG ACTATACATT GACAGAAAAC

ATTACGATTG AATACAATAC GGTCTCTGCA AACGCTGGCC AAATCTATAC AGAAACAACA

ATCGACTCTG AAACATTGAA CCAGATGTCT GCTAGCAAGA AAAAAGTCAC CACTGCGCCA

ATCACATTGA AATTCTCAGA AGGTGATGCG GAAGGTATTG TTTATTTAGC AACTGCCACA

TTCTACACGC ATAACGTAGA GGATGAAAAC CAAGCAATTG CGAAGGTTTC TTTTCAACTA

ATTCATAATG TCACCCATAC AGCAACCGAA TTTACAACAG ATGAAAAAGG TCAATACTCC

TTTGATGCCA TCATGACAGG TOATTATACT TTGCGAGTAA CGAATGTACC GCAGGAATAT

TCCGTGGATG AAGAGTATTT GACAGGAAAA GCCATTAAGC TGGTCAAACG ACACAACCAA

CTAAAAATTC CATTAACGAA AACAATTGAT CACAGTCCTT TACAAGTCAA AGATTCAACG

ATTTATGTCG GCGATTCATG GAAACCAGAA CAGAACTTTG TTTCAGCAAC AGATAAAACA

GGTCAAGACG TTCCCTTCGA AAAAATCACT GTTTCAGGTC AAGTTGATAA CANCAAAGCA

GCCGTTTATC CAATTATTTA CAGTGACGAA GGTAAAGAAG AAACAGCCTA TGTGACCGTC

AAACCCCACC AATCTAAGTT AGAGGTCAAA GATACAACGA TTTATGTTGG TGATTCGTGG

AAACCAGAAG ATAATTTCGT TTCAGCCACA GACAAAACAG GTCAACACGT NCCGTTTGAA

AAAATTGATG TTCAGCGAAC AGTCAATGTT CATAAAATAC GCCATTATGA AATTGTCTAT

AAAAATGGCA NAAAAGAAGC GAAAGCAATC GTTCATGTCC GTGATGACAG TCAGTTAGAG

GTTAAAGATA CAACGATTTA TGTTGGTGAT TCCTGGAAAC CAGAAGATAA TTTCGTTTCA

GCAACAGACA AAACAGGCCA AGACGTTCCG TTTGAAAAAA TCACTGTTTC AGGTCAAGTT

GATACTAGCA AAGCAGGCGT TTATCCAATC GTTTACAGTT ACGAAGGTAA AGAAGAAACA

GCTAATGTCA CTCTCAAACC CGACCAATCT AAGTTAGAGG TTAAAGATAC AACGATTTAT

GTGGGCGATA AATCGGAACC AGAAGATAAT TTCGTTTCAG CAACAGACAA AACAGGTCAA

GATGTCCCGT TTGAAAAAAT TGACGTTCAG GGAACAGTGA ATCTTGATAA AATAGGCGAT

TATGAAATTG TCTATAAAAA TGGCACAAAA GAAGCGAAAG CAATCGTTCA TGTCCGTGAT

CACAGTCAGT TACAGGTCAA AGATACAACA ATTTATGTGG GTGATAAATG GCAAGCACAA

GATAACTTCG TTTCCGCGAC AGACAAAACA GGTCAAGACG TTCCGTTTGA AAAAATTGAT

GTTCAGGGAA CAGTGAATGT TGATAAAATA GGCGATTATC AAATTGTCTA TAAAAATGGC

ACAAAAGAAG CGAAAGCAAT CGTTCATGTC CGTGATCATA GTCGTTTACA AGTCAAGGAT

ACAACGATTT ATGTCGGCGA TTCNTGGANA CCAGAAGNGA ACTTTGTTTC AGCNACAGAT

AAAACAGGTC AAGATCTCCC ATTCGAAAAA ATCACTGTT

EF104-2 (SEQ ID NO:402)

MKKKTF SFVMLSILLA QNFCFAVNAY AVTTTEAQTE TTDTAKKEAE LSNSTPSLPL

ATTTTSEMNQ PTATTESQTT EASTTASSDA ATPSEQQTTE DKDTSLNEKA LPDVQAPITD

ELLDSMSLAP IGGTEYSQTE VHRELNTTPV TATFQFAVGN TGYAFGSVYT VQLPEHLGYS

TVSGEVTGIG ATWAVDAATK TLSITFNQRV SDTSFKVELK SYLTTEAEPL IKIETPGKNK

KTYSFDLYEQ VEPIQYNERT RTTGLDCETF YNLDRTLTGN QTLELLTTET PGAVFGKQDN

LEPQVFSYDV DINOQILPET QTLLTPGKDY TLSDNSLGRI AVTVPNNNQQ KAYSLSINRT

IYLESASDYN YLYSQQYPTT KIGSISLKST TGTKQTTDFT AKTSQTSKVI ADREHRSMSY

ISFQSKGKYY VTIYGTLTET KVGQQIVLES TNCQEIKNPK FTAYGPLYEN VKLEDYFDIK

TEGGKLTLTA TKDSYLRINI SDLTMDFDKK DINLSLSTPV IGPNKAIQLV SDQYIEPISV

VNPLNAETAW GNYDQNGAYS SRTTVSVMGS KEKPIQNLEI KVKHPNYLSL RATKEIYFYY

KLGTDYTVTP TSDCSVTKFT TPITNEIQIP ICFNYVPDSL PKDKSIPVDT IPITMSAEGL

TPVDTTVTTN SKRGSERTLQ SSKNQFLVNA ENDSFDSLSV RTKIPAGADV LFDIYDVSND

QVDSIYPQYW DRGQYFDKPM TPNSPGYPTI TFDENTNSYT FDFGKTNKRY IIEYKNANCW

IDVPTLYITG TAKEPQSNNN EGSASVSVQN EALDTLSATQ AANPTLKNVT KTTVTTKNID

NKTHRVKNPT IELTPKGTTN AQIDLNSITV KGVPEDAYSL EKTTNGAKVI FKDYTLTENI

TTEYNTVSAN AGQIYTETTI DSETLNQMSA SKKKVTTAPI TLKFSEGDAE CIVYLATATE

YTHNVEDENQ AIAKVSFELI DNVTHTATEF TTDEKGQYSF DAIMTGDYTL RVTNVPQEYS

VDEEYLTGKA TKLVKCDNQL KTPLTKTIDH SRLQVKDSTI YVGDSWKPEE NFVSATDKTC

QDVPFEKTTV SGQVDNXKAG VYPIIYSDEG KEETAYVTVK PDQSKLEVKD TTIYVGDSWK

PEDNFVSATD KTGQDVPFEK IDVQGrJNVD KIGDYEIVYK NGXKEAKAIV HVRDDSQLEV

KDTTTYVGDS WKPEDNFVSA TDKTGQDVPF EKITVSCQVD TSKAGVYPIV YSYEGKEETA

NVTVKPDQSK LEVKDTTIYV GDKWEPEDNF VSATDKTGQD VPFEKIDVQG TVNVDKIGDY

EIVYKNCTKE AKATVHVRDD SQLEVKDTTI YVGDKWEAED NFVSATDKTG QDVPFEKTDV

QGTVNVDKIG DYEIVYKNGT KEAKAIVHVR DDSRLQVKDT TIYVGDSWXP EXNFVSATDK

TGQDVPFEKI TV

EF104-3 (SEQ ID NO:403)

TGTAA CAACGACAGA AGCACAAACA

GAGACCACTG ATACAGCAAA AAAAGAGGCA GAGTTATCGA ACTCAACACC ATCTTTACCT

TTAGCAACAA CGACTACTTC AGAAATGAAT CAACCAACTG CAACAACTGA ATCGCAAACC

ACAGAGGCGA GCACAACAGC TTCCAGTGAT GCTGCTACAC CATCTGAACA ACAAACAACG

GAGGACAAGG ACACCTCACT TAATGAAAAA GCCCTGCCAG ATGTTCAAGC GCCAATTACA

GATCAACTAC TTGACAGTAT GAGTCTTGCG CCGATTGGTG GAACAGAATA CAGCCAAACA

GAGGTTCACC GCGAATTAAA TACAACACCG GTAACCGCTA CGTTCCAATT TCCTGTTGGA

AACACAGGTT ATCCACCTGG ATCAGTTTAT ACAGTTCAAT TACCAGAACA TTTAGGTTAT

TCAACTGTCA GCGGAGAAGT CACAGGCATT GGCGCAACTT GGGCAGTCGA TGCGGCGACC

AAAACATTAA GTATTACGTT TAATCAACGA GTTTCAGATA CTTCCTTTAA AGTAGAACTA

AAAAGTTATC TAACAACAGA GGCGGAACCA TTAATCAAAA TTGAAACTCC AGGAAAAAAT

AAAAAAACCT ACTCGTTTGA TTTATATGAA CAAGTGGAAC CAATTCAATA TAACGAACGA

ACCAGAACGA CGGGGTTAGA TGGCGAAATT TTTTATAATT TAGACCGGAC GTTAACTGGC

AATCAAACAT TAGAATTATT AACAACAGAG ACGCCAGGCG CTGTCTTTGG AAAACAAGAT

AACTTGCAAC CTCAAGTTTT CAGTTACGAT GTCGACATTA ATGGTCAAAT TTTACCAGAA

ACGCAAACCT TCTTAACACC TGGCAAAGAT TATACATTAA GCGATAATTC ACTCGGGCGG

ATTGCTGTAA CTGTTCCAAA CATGAATCAA CAAAAAGCCT ATTCCTTATC GATTAATCGG

ACAATTTATT TAGAGAGTGC TTCGGACTAT AACTACTTAT ATTCGCAGCA GTATCCAACA

ACAAAAATTG GGTCAATTTC TTTCAAAAGT ACGACAGGAA CTAAACAAAC AACCGATTTT

ACTCCTAACA CGACTCAAAC AAGTAAAGTA ATTGCTGATC GTGAAATGCG TAGTATGTCC

TATATCAGTT TTCAAAGCAA AGGGAAATAT TATGTAACAA TTTATGGCAC GTTAACAGAA

ACAAAAGTGG GTCAACAAAT CGTATTAGAG AGTACAAACG GTCAAGAAAT TAAGAATCCT

AAATTTACGG CGTATGGTCC TTTATATGAA AATGTAAAAT TGGAAGACTA TTTTGATATT

AAAACTGAAG GTGGCAAGCT CACTTTAACG GCCACAAAAG ATAGCTATTT AAGAATAAAT

ATTTCTGATT TAACAATGGA TTTTGACAAG AAGGACATTA ATCTATCATT AAGTACACCT

GTAATTGGTC CTAATAAACC CATTCAATTA GTATCCGATC AATATATTGA ACCAATTAGT

GTTGTTAATC CTTTGAATGC TGAAACTGCT TGGGGTAATT ATGATCAAAA TGGTGCCTAT

TCATCAAGAA CAACTGTCTC AGTTATGGGA AGCAAAGAGA AACCGATTCA AAATTTAGAA

ATTAAAGTAA ACCATCCTAA TTATCTTTCA TTACGAGCTA CAAAACAAAT TTATTTTTAT

TACAAGTTAG GAACGGATTA TACAGTAACG CCAACGTCAG ATGGTTCACT TATTAAGTTC

ACTACGCCAA TAACCAACGA AATCCAAATT CCAATTGGTT TTAATTATGT GCCAGATAGT

TTGCCAA4AG ATAAAAGTAT CCCAGTCGAT ACGATACCGA TAACAATGAG TGCTGAAGGT

TTAACTCCAG TTGATACGAC AGTAACTACT AATAGTAAGC GTGGTTCTGA ACGAACACTT

CAAAGTAGTA AAAATCAATT CCTTGTCAAT GCACGAAATG ATTCTTTTGA CTCACTAAGC

GTCCGTACAA AAATTCCAGC TCGCGCCGAT GTTCTTTTTG ACATTTATGA TGTTTCAAAC

GATCAGGTAG ATTCAATTTA TCCACAATAC TCGGACCGCG GTCAATACTT TGATAAACCA

ATGACGCCAA ACAGCCCTGG ATATCCAACG ATTACTTTTG ACGAAAATAC CAATAGTTAC

ACGTTTGATT TTGGAAAAAC CAACAAACGT TACATTATTG AGTATAAAAA CGCCAATGGC

TGGATCGACG TGCCAACTCT TTATATAACA GGGACAGCGA AAGAACCACA ATCGAATAAT

AATGAAGGCT CTGCTTCGGT TTCTGTTCAA AATGAAGCCT TAGACATTTT GAGTGCAACA

CAACCGGCGA ATCCAACATT AAAAAATGTA ACAAAAACGA CAGTAACAAC AAAAAATATT

GATAATAAAA CACATCGTGT GAAAAATCCA ACGATTGAAT TAACACCAAA AGGCACAACC

AATCCTCAAA TCGATTTGAA TTCTATTACC CTGAAAGGCG TCCCAGAACA TGCTTATTCA

TTAGAGAAGA CTACAAACGG TGCGAAAGTC ATTTTTAAAG ACTATACATT GACAGAAAAC

ATTACGATTG AATACAATAC GGTCTCTGCA AACGCTGGCC AAATCTATAC ACAAACAACA

ATCGACTCTG AAACATTGAA CCAGATGTCT GCTAGCAAGA AAAAAGTCAC CACTGCGCCA

ATCACATTGA AATTCTCAGA AGGTGATGCG GAAGGTATTG TTTATTTAGC AACTGCCACA

TTCTACACGC ATAACGTAGA GGATGAAAAC CAACCAATTG CGAAGGTTTC TTTTGAACTA

ATTGATAATG TCACGCATAC AGCAACCGAA TTTACAACAC ATGAAAAAGG TCAATACTCC

TTTGATGCCA TCATCACACG TGATTATACT TTGCGAGTAA CGAATGTACC CCAGGAATAT

TCCGTGGATG AAGAGTATTT CACAGGAAAA GCCATTAAGC TGGTCAAAGG AGACAACCAA

CTAAAAATTC CATTAACCAA AACAATTGAT CACAGTCGTT TACAAGTCAA AGATTCAACG

ATTTATGTCG GCGATTCATG GAAACCAGAA GAGAACTTTG TTTCAGCAAC AGATAAAACA

GGTCAAGACG TTCCCTTCGA AAAAATCACT GTTTCAGGTC AAGTTGATAA CANCAAAGCA

CGCGTTTATC CAATTATTTA CAGTGACCAA GGTAAAGAAG AAACAGCCTA TGTGACCGTC

AAACCCGACC AATCTAAGTT AGAGGTCAAI GATACAACGA TTTATGTTGG TGATTCGTGG

AAACCAGAAG ATAATTTCGT TTCAGCGACA GACAAAACAG GTCAAGACGT NCCGTTTGAA

AAAATTGATG TTCAGGGAAC AGTGAATGTT GATAAAATAG GCGATTATGA AATTGTCTAT

AAAAATGGCA NAAAAGAAGC GAAAGCAATC GTTCATGTCC GTGATGACAG TCAGTTAGAG

GTTAAAGATA CAACGATTTA TGTTGGTGAT TCGTGGAAAC CAGAAGATAA TTTCGTTTCA

GCAACAGACA AAACAGGCCA AGACGTTCCG TTTGAAAAAA TCACTGTTTC AGGTCAAGTT

GATACTAGCA AAGCAGCCGT TTATCCAATC GTTTACAGTT ACGAAGGTAA AGAAGAAACA

GCTAATGTGA CTGTCAAACC CGACCAATCT AAGTTAGAGG TTAAAGATAC AACGATTTAT

GTGGCCGATA AATGGGAACC AGAAGATAAT TTCGTTTCAG CAACAGACAA AACAGGTCAA

GATGTCCCGT TTGAAAAAAT TGACGTTCAG GCAACAGTGA ATGTTGATAA AATAGGCGAT

TATGAAATTG TCTATAAAAA TGGCACAAAA GAAGCGAAAG CAATCGTTCA TGTCCGTGAT

GACAGTCAGT TAGAGGTCAA AGATACAACA ATTTATGTCG GTGATAAATG GGAAGCAGAA

GATAACTTCG TTTCCCCGAC AGACAAAACA GGTCAAGACG TTCCGTTTGA AAAAATTGAT

GTTCAGGGAA CAGTGAATGT TGATAAAATA GGCGATTATG AAATTGTCTA TAAAAATGGC

ACAAAAGAAG CGAAAGCAAT CGTTCATGTC CGTGATGATA GTCGTTTACA AGTCAAGGAT

ACAACGATTT ATGTCGGCGA TTCNTGGANA CCAGAAGNGA ACTTTGTTTC AGCNACACAT

AAAACAGGTC AAGATGTCCC ATTG

EF104-4 (SEQ ID NO:404)

VTTTEAQTE TTDTAKKEAE LSNSTPSLPL

ATTTTSEMNQ PTATTESQTT EASTTASSDA ATPSEQQTTE DKDTSLNEKA LPDVQAPITD

ELLDSMSLAP IGGTEYSQTE VHRELNTTPV TATFQFAVGN TGYAPGSVYT VQLPEHLGYS

TVSGEVTGIG ATWAVPAATK TLSITFNQRV SDTSFKVELK SYLTTEAEPL IKIETPGKNK

KTYSFDLYEQ VEPIQYNERT RTTGLDGEIF YNLDRTLTGN QTLELLTTET PGAVFGKQDN

LEPQVFSYDV DINGQILPET QTLLTPGKDY TLSDNSLGRI AVTVPNNNQQ KAYSLSINRT

IYLESASDYN YLYSQQYPTT KIGSISLKST TGTKQTTDFT AKTSQTSKVI ADREMRSMSY

ISFQSKGKYY VTIYGTLTET KVGQQIVLES TNGQEIKNPK FTAYGPLYEN VKLEDYFDIK

TEGGKLTLTA TKDSYLRINI SDLTMDFDKK DINLSLSTPV IGPNKAIQLV SDQYIEPTSV

VNPLNAETAW GNYDQNGAYS SRTTVSVMGS KEKPIQNLEI KVKHPNYLSL RATKEIYFYY

KLCTDYTVTP TSDGSVIKFT TPITNEIQIP IGFNYVPDSL PKDKSIPVDT IPTTMSAEGL

TPVDTTVTTN SKRGSERTLQ SSKNQFLVNA RNDSFDSLSV RTKIPAGADV LFDIYDVSND

QVDSIYPQYW DRGQYFDKPM TPNSPGYPTI TFDENTNSYT FDFGKTNKRY IIEYKNANGW

IDVPTLYITG TAKEPQSNNN EGSASVSVQN EALDILSATQ AANPTLKNVT KTTVTTKNID

NKTHRVKNPT IELTPKGTTN AQIDLNSITV KGVPEDAYSL EKTTNGAKVI FKDYTLTENI

TIEYNTVSAN AGQIYTETTI DSETLNQMSA SKKKVTTAPI TLKFSEGDAE GIVYLATATF

YTHNVEDENQ AIAKVSFELI DNVTHTATEF TTDEKGQYSF DAIMTGDYTL RVTNVPQEYS

VDEEYLTGKA IKLVKGDNQL KIPLTKTIDH SRLQVKDSTI YVGDSWKPEE NFVSATDKTG

QDVPFEKITV SGQVDNXKAG VYPIIYSDEG KEETAYVTVK PDQSKLEVKD TTIYVGDSWK

PEDNFVSATD KTGQDVPFEK IDVQGTVNVD KIGDYEIVYK NGXKEAKAIV HVRDDSQLEV

KDTTIYVGDS WKPEDNFVSA TDKTCQDVPF EKITVSCQVD TSKAGVYPIV YSYEGKEETA

NVTVKPDQSK LEVKDTTIYV GDKWEPEDNF VSATDKTGQD VPFEKIDVQG TVNVDKIGDY

EIVYKNGTKE AKAIVHVRDD SQLEVKDTTI YVGDKWEAED NFVSATDKTG QDVPFEKIDV

QGTVNVDKIG DYEIVYKNGT KEAKAIVHVR DDSRLQVKDT TIYVGDSWXP EXNFVSATDK

TGQDVPF

EF105-1 (SEQ ID NO:405)

TAAATGAAAA AAACAGTCGT CTACTCCTTG TTATTCGGAA CAATGTTGCT TGGCGCCACT

GTTCCTGCTG AAGCGGCGAC GGTCGTTTTT GATAGCGAAC AGTCGATTGT TTTTACCCCA

AGCACAGATG GGACGGATCC AGTAAATCCA GAAAATCCCG ATCCAGAAAA ACCAGTTCGA

CCAGTCGATC CAACGAATCC TGATGGACCT AATCCAGGTA CCCCTGGTCC ACTTTCCATC

GATTATGCCT CAAGTTTGGA TTTTGGGAGT AATGAGATAT CCAATAAGGA TCAAACGTAT

TTTGCCAGAG CGCAAACCTA TAGAAATCCA GATGGTTCAG CAAGTGAATT GGCAACTGCT

AATTATGTAC AAGTAAGTGA TTTACGGGGA ACCAATGCTG GCTGGGTTTT AAAAGTGAAA

CAAAATGGTC AATTTCGTAA TGCAGAAACA TTACACAAAG AATTAACAGG CGCCACCGTC

GCCTTTACTG AGCCCAGTGT TCGCTCAAAT GCGACGCACG TATTGCCGCC AACTGCTACC

GCAAACATTC AATTAGATGC TGCGGGCGCA CAAACTGTTG TCATGCAAGC CCCAGAAAAG

ACCGCCGCCG GAACGTGGAT CACGCTGTGG GGGCAAGCAG AAAAAGTGAC CGAAAAAAAT

CAACAAGCAC AGCAAGTAAA TGCCACAATC ACACGGGCAA TCTCACTAAC TGTTCCTGGG

AAAACCCCTA AGGATGCAGT ACAATATAAA ACAACATTGA CTTGGCTACT TTCAGATGTA

CCAGTAAATA ATGGAGGGAA ATAA

EF105-2 (SEQ ID NO:406)

MKKTVVYSLL FGTMLLGATV PAEAATVVFD SEQSIVFTPS TDGTDPVNPE NPDPEKPVRP

VDPTNPDGPN PGTPGPLSID YASSLDFGSN EISNKDQTYF ARAQTYENPD GSASELATAN

YVQVSDLRGT NAGWVLKVKQ NCQFRNAETL HKELTGATVA FTEPSVRSNA TDVLPPTATA

NIQLDAACAE TVVMQAPEKT GAGTWITLWG QAEKVTEKNQ QGQQVNATIT RAISLTVPCK

TPKDAVQYKT TLTWLLSDVP VNNGGK

EF105-3 (SEQ ID NO:407)

GGCGAC GGTCGTTTTT GATAGCGAAC AGTCGATTGT TTTTACCCCA

AGCACAGATG GGACGGATCC AGTAAATCCA GAAAATCCCG ATCCAGAAAA ACCAGTTCGA

CCAGTCGATC CAACGAATCC TGATGGACCT AATCCAGGTA CCCCTGGTCC ACTTTCCATC

GATTATGCCT CAAGTTTGGA TTTTGGGACT AATGAGATAT CGAATAAGGA TCAAACGTAT

TTTGCCAGAG CGCAAACCTA TAGAAATCCA GATGGTTCAG CAAGTGAATT GGCAACTGCT

AATTATGTAC AAGTAAGTGA TTTACGGCGA ACCAATGCTG GCTGGGTTTT AAAAGTGAAA

CAAAATGGTC AATTTCGTAA TGCAGAAACA TTACACAAAG AATTAACAGG CGCCACCGTC

GCCTTTACTG AGCCCAGTGT TCGCTCAAAT GCCACGGACG TATTGCCGCC AACTGCTACC

GCAAACATTC AATTAGATGC TGCGGGCGCA GAAACTGTTG TCATGCAACC CCCAGAAAAG

ACCGGCGCCG GAACCTGGAT CACGCTGTGG GGGCAAGCAG AAAAAGTGAC CGAAAAAAAT

CAACAAGGAC AGCAAGTAAA TGCCACAATC ACACGGGCAA TCTCACTAAC TGTTCCTGGG

AAAACCCCTA AGGATGCAGT AC

EF105-4 (SEQ ID NO:408)

ATVVFD SEQSIVFTPS TDGTDPVNPE NPDPEKPVRP

VDPTNPDGPN PGTPGPLSID YASSLDFGSN EISNKDQTYF ARAQTYRNPD GSASELATAN

YVQVSDLRGT NAGWVLKVKQ NGQFRNAETL HKELTGATVA FTEPSVRSNA TDVLPPTATA

NIQLDAAGAE TVVMQAPEKT GAGTWITLWG QAEKVTEKNQ QGQQVNATIT PAISLTVPGK

TPKDAV

EF106-1 (SEQ ID NO:409)

TAGTCGTTTA TGAAGAAAAA AATCGTTGGT ACAATTACGT TGTTGGCTTT AAGTGCGTTA

TTAGTTGGTG GAGCACGAGG CGCTTTGACG CCAGAAGCAT ACGTTCCTCA AAGCGTAGAC

AATCCCAATA ATTTAGGGGA TTTACCTGAG TATTTACGTT CAGTTGGTAT TAGACAAGAT

GAACCATTAT CAGAAAAAGA TTGGGCTGGA ACACGCGTTT ATGATCGAAA TGGGAATGAC

TTAACAGATG AAAATCAAAA CCTATTACAT GCAATCAAAT TTGATGCAAC CACTAGTTTC

TATCAATTTT TTGATAAAGA GACTGGAGAA TCAACAGGAG ATGAACGAAC CTTCTTTATG

ACCGCTCGTA TTACAGATGT TTCCCGTCTT GTAATTATTT CTGAAACCAA AAATTATCAA

CGTGTATACC CACTTAGAAC TTTATACCAA GATACTTTTA CGTATAGACA GATGGGGAAA

GATAAAAACG GAAATGATAT TGAAGTTTTC GTAGAAAACA AAGCAACCTC AGGACCAGTT

TATGGTCGTC CGCAGCCATA CCCCAATAAT CGTCCCAGAA CACTAGAATT CACGAATGGA

CGCCGTGCCA TGACAGAACA AACAGGCCAG ATTGATCTAA ATCGACAAGG CGATGAAATT

ATTGGTAAAA CTTCCTTTGA TGGGACACCG CAACTTCTTT GGAATGGCAC AAAAGTAGTG

GATAAAGATG GCAATGACGT AACTTCGGCC AACCAAAACT TTATCAGCTT AGCGAAATTT

GACCAAGATA GCAGCAAATA TGAATTTTTC AATTTACAAA CTGGTGAAAC TCGTGGCGAC

TATGGCTACT TTAAACTAGG AAATCAAAAT AAATTCCGTG CCCATGTTTC CATTGGAACC

AATCGCTATG GCGCTGTCTT AGAGTTAACA GAATTGAATG ATAATCGTTT TACGTACACA

CGAATGGGTA AAGATAACGA AGGAAACCAT ATCCAAGTCT ATGTGGAACA TCAACCATAC

CAAGGAACTT TTAATCCTGA ATTTACCTTT TAA

EF106-2 (SEQ ID NO:410)

MKKKIVGT ITLLALSALL VGGAGGALTA EAYVPQSVDN PNNLGDLPEY LRSVGIRQDE

GLSEKDWAGT RVYDRNGNDL TDENQNLLHA IKFDATTSFY EFFDKETGES TGDEGTFFMT

AGITDVSRLV IISETKNYQG VYPLRTLYQD TFTYRQMCKD KNGNDIEVFV ENKATSGPVY

GRPQPYPNNR PRTLEFTNGR RAMTEQTGQI DVNRQGDETI GKTSFDGTPQ LLWNGTKVVD

KDCNDVTSAN QNFISLAKFD QDSSKYEFFN LQTGETRGDY GYFKVGNQNK FRAHVSIGTN

RYGAVLELTE LNDNRFTYTR MGKDNEGNDI QVYVEHEPYQ GTFNPEFTF

EF106-3 (SEQ ID NO:411)

AT ACGTTCCTCA AAGCGTAGAC

AATCCCAATA ATTTAGGGGA TTTACCTGAG TATTTACGTT CAGTTGGTAT TAGACAAGAT

GAAGGATTAT CAGAAAAAGA TTGGGCTGGA ACACGCGTTT ATGATCGAAA TGGGAATGAC

TTAACAGATG AAAATCAAAA CCTATTACAT GCAATCAAAT TTGATGCAAC CACTAGTTTC

TATGAATTTT TTGATAAAGA GACTGGAGAA TCAACAGGAG ATGAAGGAAC CTTCTTTATG

ACCGCTGGTA TTACAGATGT TTCCCGTCTT GTAATTATTT CTGAAACCAA AAATTATCAA

GGTGTATACC CACTTACAAC TTTATACCAA GATACTTTTA CGTATAGACA GATGGGGAAA

GATAAAAACG GAAATGATAT TGAAGTTTTC GTAGAAAACA AAGCAACCTC AGGACCAGTT

TATGGTCGTC CGCAGCCATA CCCCAATAAT CGTCCCAGAA CACTAGAATT CACGAATGGA

CGCCGTGCCA TGACAGAACA AACAGGCCAG ATTGATGTAA ATCGACAAGG GGATGAAATT

ATTGGTAAAA CTTCCTTTGA TGGGACACCG CAACTTCTTT CGAATGGCAC AAAAGTAGTG

GATAAAGATG GCAATGACGT AACTTCGGCC AACCAAAACT TTATCAGCTT AGCGAAATTT

GACCAAGATA GCAGCAAATA TGAATTTTTC AATTTACAAA CTGGTGAAAC TCGTCGCGAC

TATGGCTACT TTAAAGTAGG AAATCAAAAT AAATTCCGTG CCCATGTTTC CATTGGAACC

AATCGCTATG GCGCTGTCTT AGAGTTAACA GAATTGAATG ATAATCGTTT TACGTACACA

CGAATGGGTA AAGATAACGA AGGAAACGAT ATCCAAGTCT ATGTGGAACA TGAACCATAC

CAAGGAACTT

EF106-4 (SEQ ID NO:412)

YVPQSVDN PNNLGDLPEY LRSVGIRQDE

GLSEKDWAGT RVYDRNGNDL TDENQNLLHA IKFDATTSFY EFFDKETGES TGDEGTFFMT

AGITDVSRLV IISETKNYQG VYPLRTLYQD TFTYRQMGKD KNGNDIEVFV ENKATSGPVY

GRPQPYPNNR PRTLEFTNGR RAMTEQTGQI DVNRQGDEII GKTSFDGTPQ LLWNGTKVVD

KDGNDVTSAN QNFISLAKFD QDSSKYEFFN LQTGETRGDY GYFKVGNQNK FRAHVSIGTN

RYGAVLELTE LNDNRFTYTR MGKDNECNDI QVYVEHEPYQ GT

EF107-1 (SEQ ID NO:413)

TAAAAAACGG CACTCAATAT GTCAAAATTT GAAATTTCAA GCTGTGTGTT CTTTGGTAAA

ATANATANAA AAATGCTAGT TATCAGTATC GATAATAACA GGATACTGAT TAAGAAAGGA

CTTTATAGAG ACTATAGATT GAATTTTTAC ATAGAAAGAA GGACCAAGAT GAAGCGAGTA

AATTGGAAAA GATGGCTAGT TGTTGGGTTA AGTTGTTCTT TGTTCATGGA TTCAGTGGTT

GGTGTGACTG TGTTAGCGGA AACGATTACT GGGGCGACGG AGCAAGGAGT AGCAACATCT

CAGTCGAGTC ACGAAGCGAG CCAGACGACG CAAACAACCG AAGAGTCACA GGCAACGGTC

GCTAGTGAAG CGAAAACAGT ACCGCCACAG GAAACGGCAA GAATTGCTTC TCGAGCGATT

GGTTATTCTT CTGTGGAAGG GCGCGAGATT CCCTTTTTCT TTGTGGAGGA AGACGGGACG

TTGTTTGATC CCGACCGAAT TACGATGGCG GTCAATCTTT CCACGTTTTC GTTTTATGAA

CACAAATTAC AACGAACCCC CCTTGAGCCC ACCACTGTGA ATGGCGGAAA GTTACTGTCT

ATTCCAACGT CACCAGCTTT TAAATATGAT ACAAATAACC AGAATCCAAG TAATATTTAT

GGCGTTTCTG AAGTGTCGTT TACTATTCCT AAGGAGTATC AAAGCCTGGA CATTCGACCA

AGTACGTTTT ATACAGGAGA CACTACGCAA TATCCAGTGC CAACGGTTTT TGCGAACGTT

GGGGGCAAAG TGACGAACTA TGTGGGCGCC AATGCGGAGA CGGAATTAGA GTTAACCAAT

GAAAAAATGC CCAATAAGCT GACGTTTGGT CCTAAAAAGA CGTTTAAATA TACGGTACCT

ACGGCACCAG GAGGCGTTAC GTATGCGCTG ACCTATTTTT ATGGAGATGT CGGCGGTCCA

ACTAGTTCGC ACCAAAGACG AGGAACAGCG GGTCCTGTGT ATTATTATTT AACAAAGCGG

CGTGTCACGG AAAAATTTGA GAATCCCGCA GGCGGGGCGA TTCCTGCGCC AGAAGGTTAT

ACGCAGGATA AGAAAACCAT TGTAACAGGG GAGGATTTTA CTTTTACCCA AGAAGGCACC

TTGCCTGAAC GTTACACAGG CAGTGATGGG AAGACGTATT TATTTAAAGG TTGGTACAAA

GGGAATGCGA AACCTAGCAC CTTGGAAACC ACCAAAACGC CTAGTTATGC GGTGACCTAT

GATGACAATG ACGATTTGCA TGTGGTCTAT GAAGAAGCAG TGATGAAAAC CTATACGTTG

CCAGCGAGAG AAGCTTTGTT CGGCTATGTT GATGAGCAAG GAAACTTGAT TAATCCCGCC

AAGTTTAAGC TAAGTGCGAC CATGGGTGAA ACTGACGGAG CCACAGGGGA AATGACGACT

TTTCCCACAA TTGATGGAAT CGATATGCCA GCAAGTCAAT TAAAGAAATT AGCCATCCCG

CAAAAAGTCT ACACACGCCC AGACGATGGG ACAATCGTAA CTTATGGCCC GCAAGAAGTG

AGTGTTGAAA TTCCTAAGTA TTACCAGACG ATTTCGATTT CACCAACTAC TGCGTATACA

GGGGATAAAA CCAAGTATCC AGTACCAAAT GAAGTGCGCC GTGGCATCGA AAACCCCGAC

AACATTGTTA GTAGTTTAGT GGGAANCNCT GCGTATAACT TGACCCAAAA AAGTGCCACA

CGCTATACTG CCCGCCGTTC TTACTGGANG TGGGGCCCCA CGAAGACACT TTACTCAATG

AGTATCTATT CAGGAACTGC TGCGGGCAAC TATAATTTAT CGACCCCTGA TGGCACCATT

TATTATTACT TAGAAAATCG GCGGGTCACT GAACATTTTG TAGACGAAAG TGGCGCAAAA

ATCACGCCAC CAACTGGCTT TACACAAGGA AATCAGCTAG TGGTGGACAG TGAAAACTAT

GTCTACACTG TCGCAAAAGC TTTGCCGAAG ATCTACCAAG CTGGTGAAAA AACCTATATC

TTCCAAGGCT GGTTTAAAGG CAAAACCAAG CCAGCAACAT TAAAGACGAC AACGACCCCA

AGTTTTACAC CAACTTTTAA TGATGAGGAC GACATGACCG CTGTGTACCA AGAAGCGATT

CCCACCGCGG AACTAACGTT AACAGGTGCC GTTGACATAA TCGAAAATGG CGCCACAATG

GATTACTGGG AGGCGCTACT GAAGAACACA GGCGAAGCGC CGTTAACCAC CATTAAAATC

AAGCCAACGG CAACTTGGGC GGCTGGCATC GGCGCACCCA ACACGATATT TGTACAAGGA

ACGGGTCAAA ACACCAAACC TTTTCCTGTC ACCAAAGAAC AATGGACGAC CGGTGCAGGA

GTGTCCATCA CGTTGGATCA GCCTTTACCA GCTGGCGGTC AATTAAAAAT GAACTTATTA

GGAACCGCCG TTACAGCAAA TCCTCGTCAA GTTTTAACCG CTGATGTTGA AGTAACGGGC

AACTTTGGCA GTTTAACTGC CAAAGATACG GTCCGTATTA AAGACTTAGA TCAAGAAATT

ACGAGTCCTG ACGGCGACGG CTTTATTAGT ACCCCGACAT TTGATTTTGG TAAACTAGCA

ATTTCAGGAA GTAAGCAACA ATATGGTTTG AAGAAGGCCG CAGATTACTA CGGCAATGGC

ACTCGCAACC CTTATTTACG CCTGAATACT AGCCAAGCCA ATTGGAGTTT AACGGCCCAG

CTATCGCAAC CAAAATCAGC CACAGACAGC TTGCCAACAA CGACCCGCTT GTTGCTAGGA

ACGGCCGCTG CTGCCAGCTT TACCGATTAC AACCAACCAA CAGAAACCAG GACACCACTT

GGCAAGACCA GCACCGTGAC TTTAACCGCC GACAATACCG CAACAGCGGT GGTCGCAAAC

CAACACTTCA CAGGCAGTGA CGTCTATCAG TTGGACTTCA CGTTTGCTAA CATCAAACTA

GAAGTGCCAG CCAACCAAGG TATGGCTGGC CAACAATACC AAGCCGCCGT CACGTGGAAT

TTAGTGACTG GCCCCTAA

EF107-2 (SEQ ID NO:414)

MKRVN

WKRWLVVGLS CSLFMDSVVG VTVLAETITG ATEQGVATSQ SSDEASQTTQ TTEESQATVA

SEAKTVPPQE TARIASRAIG YSSVEGREIP FFFVEEDGTL FDPDRITMAV NLSTFSFYEE

KLQRTPLEPT TVNCGKLLSI PTSPAFKYDT NNQNPSNIYG VSEVSFTIPK EYQSLDIRPS

TFYTGDTTQY PVPTVFANVG GKVTNYVGAN AETELELTNE KMPNKLTFGP KKTFKYTVAT

APGGVTYALT YFYGDVGGPT SSHQRRGTAG PVYYYLTKRR VTEKFENPAG GAIPAPEGYT

QDKKTIVTGE DFTFTQEGTL PERYTGSDGK TYLFKGWYKG NAKPSTLETT KTPSYAVTYD

DNDDLHVVYE EAVMKTYTLP AREALFGYVD EQGNLINPAK FKLSATMGES DGATGEMTTF

PTIDGIDMPA SQLKKLAIPQ KVYTRPDDGT IVTYGPQEVS VEIPKYYQTI SLSPTTAYTG

DKTKYPVPNE VRRGIENPDN IVSSLVGXXA YNLTQKSATR YTARRSYWXW GPTKTLYSMS

IYSGTAGGNY NLSTPDGTIY YYLENRRVTE HFVDESGAKI TPPTGFTQGN QLVVDSENYV

YTVAKALPKE YQAGEKTYIF QGWFKGKTKP ATLKTTTTPS FTPTFNDEDD MTAVYQEAIP

TAELTLTGAV DIIENGATMD YWEALLKNTG EAPLTTIKIK PTATWAAGIG APNTIFVQGT

GQNTKAFPVT KEQWTTGAGV SITLDQPLPA GGQLKMNLLG TAVTGNPGQV LTADVEVTGN

FGSLTAKDTV RIKDLDQEIT SPDGDGFIST PTFDFGKLAI SGSKQQYGLK KAADYYGNGT

RNPYLRLNTS QANWSLTAQL SQPKSATDSL PTTTRLLLGT AAAASFTDYN QPTETRTPLG

KTSTVTLTAD NTATAVVANQ QFTGSDVYQL DFTFANIKLE VPANQGMAGQ QYQAAVTWNL

VTGP

EF107-3 (SEQ ID NO:415)

CC AGCAAGGAGT AGCAACATCT

CAGTCGAGTG ACGAAGCGAG CCAGACGACG CAAACAACCG AAGAGTCACA GGCAACGGTC

GCTAGTGAAG CCAAAACAGT ACCGCCACAG GAAACGGCAA GAATTGCTTC TCGAGCGATT

GGTTATTCTT CTGTGGAAGG GCGCGAGATT CCCTTTTTCT TTGTGGAGGA AGACGGGACG

TTGTTTGATC CCGACCGAAT TACGATGGCG GTCAATCTTT CCACGTTTTC GTTTTATGAA

GAGAAATTAC AACGAACCCC CCTTGAGCCC ACCACTGTGA ATGGCGGAAA GTTACTGTCT

ATTCCAACGT CACCAGCTTT TAAATATGAT ACAAATAACC AGAATCCAAG TAATATTTAT

GGCGTTTCTG AAGTGTCGTT TACTATTCCT AAGGAGTATC AAAGCCTGCA CATTCGACCA

AGTACGTTTT ATACAGGAGA CACTACGCAA TATCCAGTCC CAACGGTTTT TCCGAACGTT

GGGGGCAAAG TGACGAACTA TGTGGGCGCC AATGCGGAGA CGGAATTAGA GTTAACCAAT

GAAAAAATGC CCAATAAGCT GACGTTTGGT CCTAAAAAGA CGTTTAAATA TACGGTAGCT

ACGGCACCAG GAGGCGTTAC GTATGCGCTG ACCTATTTTT ATGGAGATGT CGGCGGTCCA

ACTAGTTCGC ACCAAAGACG AGGAACAGCG GGTCCTGTGT ATTATTATTT AACAAAGCGG

CGTGTCACGG AAAAATTTGA GAATCCCGCA GGCGGGGCGA TTCCTGCGCC AGAAGGTTAT

ACGCAGGATA AGAAAACCAT TGTAACAGGG GAGGATTTTA CTTTTACCCA AGAAGGCACC

TTGCCTGAAC GTTACACAGG CAGTGATCGG AAGACGTATT TATTTAAAGG TTGGTACAAA

GGGAATGCGA AACCTAGCAC GTTGGAAACC ACCAAAACGC CTAGTTATGC GGTGACCTAT

GATGACAATG ACGATTTGCA TGTGGTCTAT GAAGAAGCAG TGATGAAAAC CTATACGTTG

CCAGCGAGAG AAGCTTTGTT CCGCTATGTT GATGAGCAAG GAAACTTGAT TAATCCCGCC

AAGTTTAAGC TAAGTGCGAC CATGGGTGAA AGTGACGGAG CCACAGGGGA AATGACGACT

TTTCCCACAA TTGATGGAAT CGATATGCCA GCAAGTCAAT TAAAGAAATT AGCCATCCCG

CAAAAAGTCT ACACACGCCC AGACGATGGG ACAATCGTAA CTTATGGCCC GCAAGAAGTG

AGTGTTGAAA TTCCTAAGTA TTACCAGACG ATTTCGATTT CACCAACTAC TGCGTATACA

GGGGATAAAA CCAAGTATCC AGTACCAAAT GAAGTGCGCC GTGGCATCGA AAACCCCGAC

AACATTGTTA GTAGTTTAGT GGGAANCNCT GCGTATAACT TGACCCAAAA AAGTGCCACA

CCCTATACTG CCCGCCGTTC TTACTCGANG TGGGGCCCCA CGAACACACT TTACTCAATG

AGTATCTATT CAGGAACTGC TGGGGGCAAC TATAATTTAT CGACCCCTGA TGGCACCATT

TATTATTACT TAGAAAATCG GCGGGTCACT GAACATTTTG TACACGAAAG TGGCGCAAAA

ATCACGCCAC CAACTGGCTT TACACAAGGA AATCAGCTAG TCGTGCACAG TGAAAACTAT

GTCTACACTG TCGCAAAAGC TTTGCCGAAG ATCTACCAAG CTGGTGAAAA AACCTATATC

TTCCAAGGCT GGTTTAAAGG CAAAACCAAG CCAGCAACAT TAAAGACGAC AACGACCCCA

AGTTTTACAC CAACTTTTAA TGATGAGGAC GACATGACCG CTGTGTACCA AGAAGCGATT

CCCACCGCGG AACTAACGTT AACAGGTGCC GTTGACATAA TCGAAAATGG CGCCACAATG

GATTACTGGG AGGCGCTACT GAAGAACACA GGCGAAGCGC CGTTAACCAC CATTAAAATC

AAGCCAACGG CAACTTGGGC GGCTGGCATC GGCGCACCCA ACACGATATT TGTACAAGGA

ACGGGTCAAA ACACCAAAGC TTTTCCTGTC ACCAAAGAAC AATGGACGAC CGGTGCAGGA

GTGTCCATCA CGTTGGATCA GCCTTTACCA GCTGGCGGTC AATTAAAAAT GAACTTATTA

GGAACCGCCG TTACAGGAAA TCCTGGTCAA GTTTTAACCG CTGATGTTGA AGTAACGGGC

AACTTTGGCA GTTTAACTGC CAAAGATACG GTCCGTATTA AAGACTTAGA TCAAGAAATT

ACGAGTCCTG ACGGCGACGG CTTTATTAGT ACCCCGACAT TTGATTTTGG TAAACTAGCA

ATTTCAGGAA GTAAGCAACA ATATGGTTTG AAGAAGGCCG CAGATTACTA CGGCAATGGC

ACTCGCAACC CTTATTTACG CCTGAATACT AGCCAAGCCA ATTGGAGTTT AACGGCCCAG

CTATCGCAAC CAAAATCAGC CACAGACAGC TTGCCAACAA CGACCCGCTT GTTGCTAGGA

ACGGCCGCTG CTCCCAGCTT TACCGATTAC AACCAACCAA CAGAAACCAG GACACCACTT

GGCAAGACCA GCACCGTGAC TTTAACCGCC GACAATACCG CAACAGCGGT GGTCGCAAAC

CAACAGTTCA CAGGCAGTGA CGTCTATCAG TTGGACTTCA CGTTTGCTAA CATCAAACTA

GAAGTGCCAG CCAACCAAGG TATGGCTGGC CAACAATACC AAGCCGCCGT CACGTGGAAT

TTAGTGACTG GCCCCT

EF107-4 (SEQ ID NO:416)

EQGVATSQ SSDEASQTTQ TTEESQATVA

SEAKTVPPQE TARIASRAIG YSSVEGREIP FFFVEEDGTL FDPDRITMAV NLSTFSFYEE

KLQRTPLEPT TVNGGKLLSI PTSPAFKYDT NNQNPSNIYG VSEVSFTIPK EYQSLDIRPS

TFYTGDTTQY PVPTVFANVG GKVTNYVGAN AETELELTNE KMPNKLTFGP KKTFKYTVAT

APGGVTYALT YFYGDVGGPT SSHQRRGTAG PVYYYLTKRR VTEKFENPAG GAIPAPEGYT

QDKKTIVTGE DFTFTQEGTL PERYTGSDGK TYLFKGWYKG NAKPSTLETT KTPSYAVTYD

DNDDLHVVYE EAVMKTYTLP AREALFGYVD EQGNLINPAK FKLSATMGES DGATGEMTTF

PTIDGIDMPA SQLKKLAIPQ KVYTRPDDGT IVTYGPQEVS VEIPKYYQTI SISPTTAYTG

DKTKYPVPNE VRRGIENPDN IVSSLVGXXA YNLTQKSATR YTARRSYWXW GPTKTLYSMS

IYSGTAGGNY NLSTPDGTIY YYLENRRVTE HFVDESGAKI TPPTGFTQGN QLVVDSENYV

YTVAKALPKI YQAGEKTYIF QGWFKGKTKP ATLKTTTTPS FTPTFNDEDD MTAVYQEAIP

TAELTLTGAV DITENGATMD YWEALLKNTG EAPLTTIKIK PTATWAAGIG APNTIFWQGT

GQNTKAFPVT KEQWTTGAGV SITLDQPLPA GGQLKNNLLG TAVTGNPGQV LTADVEVTGN

FGSLTAKDTV RIKDLDQEIT SPDGDGFIST PTFDFGKLAI SGSKQQYGLK KAADYYGNGT

RNPYLRLNTS QANWSLTAQL SQPKSATDSL PTTTRLLLGT AAAASFTDYN QPTETRTPLG

KTSTVTLTAD NTATAVVANQ QFTGSDVYQL DFTFANIKLE VPANQGMAGQ QYQAAVTWNL

VTGP

EF108-1 (SEQ LD NO:417)

TAATCGGTTT GGCGGGAATC GTACATAGAA AGAAGGGACG ACATGAAGCA AACTAAGTGG

CAACGATTAG CAACCATTGG CTTGTGTAGT TCTTTAGTAA TTAACGCCTT TTCTGGTGTG

ACGGCAGTTG CGGAAACCGT GACGATTGAA AGTAGTCCGA CCGCCGAAAG TAGTGCCAAG

GAACAGACGC AAGCAAGTAG CGTGAAGGAA GAAACAACGA AAGCCAGTAC GGAAAATAGT

CAAGTAACAA CTGACACGAG TCAGGAAGAA GCAACGAAAG AAGCGGAGAA AGAAGAACCG

CAAGCAGAAG TGCAACAAGC AGAAACACCA ATCATTCCTA AACCAAAAAA AATCAATATG

AAGGCAACTT ATTCATTTTC TGCAGAAACT TATCAGTTTG GATTTGTGAA TGAATCAGGT

CAATTAATAA ATCCAGATAT TATACCAATT ACGTATAGCT ATGCCAAAGG ATCATGGAAG

ACAGATGGTT ATAATCGAAA GTGGACTAGT ATGGTTCAAG GGAGTGCTTC AACCGTAGGA

AACTTAAAGA ATGTAATAAT GCCAGCAACT TCTGTAGTTA TGCCACCAGG ACCGTCATAT

GAAGGAACTC AAGAGGTGTA CACAAACTTT TCAATTCGCA TACCAAAATA TTATGCATCA

GCGAGTCTCT ACAATAGAGA AGGTAAAATT GATTCTACTT ATCCGTTACC TGCTATTGCA

CTAGCAGGTA CTAGACCGCT ATCTTTGACT CAAAGTAGTG TAATTAGTGC ATTGGCGCTG

ACCAGTAAAG GAGACAATGT TTATACACCA CGGGAAACAT TTTTTGGAGG AGATCCTGCA

GGTGTAAAGT TTACTAATTT TTTGTATCGT ATAAATGACT TTGATGTGAA AGGTAATAAC

ATAGGTTATA AGACTGTGAG TAGCCCAATC TATTACCATC TGACCAACCG CCGTGTCACC

GAAAACTTCG TAGATACAAG TGGCGCCAAA ATCACGCCAC CAAGTAATTT CACCCAAGGG

AAACAAACGG TCATTAACAG TGATCCTTAC ACGTTCCAAC AAAGTGGTTT TTTACCCGAG

ACCTACAAAG TTGGCACGAA ATCTTACCGA TTCAAAGGCT GGTACAAAGG GAAAACCAAA

ACCGAGCCTT TGGCCACCAC TAAAACACCT AGCTATAAAG TCACGTATGA TGACAATGAT

GATTTGACGG TGGTCTATGA GGAGTTTTCA GGGTACGAGC TGCCTGCTTC GACCAATCAA

TTTGGCTTTG TGGATGAAGC GACGAACAAA TTAATTGCCC CCGACCAAGT GCACATGAAG

TATAATCTTA CTTTAAATGA AAATAATAAA AAAACAGTAA TGAGCAGTAA CTTAACGGGG

ACAGATACAG CGACACTGAA AAACTTGTCC GTGCCTGTCA ACTATTTTGA ACAATATCGC

GTCAATACGT TTTATCGCGC GAGTGACATT ACGTTTACAT TGCCCAAACG GTACAAATCA

ATCAATATTA CCAAATCAGA TGGCAAAACC GACCCAGCTT TTCCTCTTCC TAAAATCTAT

AATATAGATC AAGTAGAAAT GTCACACATG CCTGTGACCA CTTATAACAA GTTGAAACAG

CTGTCGGGCC AAACGTTTGG CTTTAATGCT TTAGCCGATC AACCTGAATT TTATACGAAA

ACGTTATTTG GGACAGAGTC TGGCATCGAT GACCCAGTCA ATTATTATAC AATGAGTGGC

CCTGTTTACT ATTATTTAGA AAACCGCAAA GTCACCGAGA ACTTCGTAGA CACCAACGGC

GCTAAAATCA CACCGCCAAC AGGTTTCACC CAAGGTAAAA AAACGGTGAT TACAAGCGAC

GCCTACACTT TCAAACAAGC AGGCACCTTA CCAGACACTT ACACAACAGG CGGTAAGACC

TACAAGTTCA AAGGTTGGTA CAAAGGCAAG TCCATACTCA ACACATTGAC AACTACCAAA

GCGCCAAGTT ATCAAGTGAC CTACGATGAC AATGATGATT TGAATGTGGT GTATGAAGAA

GAAACAGTTA CGACAGTGTA TCCATCAGTC GATATGAACT TTGTGAATGA AAAAGGCGGG

GCTTTCACAC CGGCGTTAAC TTTTAGTGGT AAGTACTATG CGCAAAGTAC GAGTGCGTAC

TTAAGAACCG ATTTATATGA CGTGACCTCA AAAAATAATG GTAATGGGCA ATATACGGTA

AGTATTAATA ATGGTAGTAT GCCATTGTCC CAAGAATTAT TGAAAAAATA TAATAATGGA

CAACCAATCA GTGCTACCAA CAGATTACAG TTTAATGTTG ATAAATTAGC CATCGACCAA

CAACTAAAAT ATCTTGACAG CATTCAATTA GACACAGCTC AAAGTAGCAA TCTCAAATCC

TATAGATATG TGTACACGAA CAATAGCTCA CTGGTTTTCG ACCCAAATGT AGCACCAGCA

GAGGTTGACC TTAGTTCAGA ATCTCTTAAC TTGCTTAATT TTGATTCAGA TGGCACCTAT

TTTTCTAATG CAAATAATAG ACTTTTTTAC ACGCATTTAG GATATAGTGG CACACCAGGA

GTTAACTATC TTCTCGTAAT GTTTCTTTTT AACGCCAAAC CTGCGGATAA GTCAAAACTT

GTCTACAAAG TCACTCGCAA ACAAGTCACC GAAAACTTCG TGGATGTCAA CGGTGCCAAA

ATCACTGCAC CAACAGGCTT CACCCAAGGT AACCAAGTAC CAATGAACAG TAACACCTTC

AAGTACACAG CCGCAAAAGC TTTACCAGCG ACGTATACTA CAGGTGGCAA AGTCTATACC

TTCCAAGGGT GGTATAAAGG GAAAACCAAG CCAAGTACGT TGAACAAAAC AACAACTCCA

ACGTTCAATG CGACCTTTGA TGGCAATGAC GATATGACCG CCATGTATAA GGAAGAAATA

CCAACAGCTA GTGTCACATT AACTCGACCA AAAGAAGTGA TTGATACGAA TACCAATGTA

ATCTGGACAA CAACGATCAC GAATACTAGC AAAGCACCCT TACAAAATCT CACCTTGAAA

AAAGGGCCCA ATTGGTCAGC TGGTCTGACG ATCCCGACCT TTATGGAAGT GACACCAGAA

GGAGAAACGA CAAAATCAAT CCCAGTAAAT AGTACACTTT GGACAGAGGG GGTTCCTTTA

CCAAATGCCC TTCCTATCGG CAAAAAAGTT TCAGTTGCTT TCACAACTCG CGCAACAGGG

AAACCAAACA CTGTTTTGAA AGCAGAAGTT GTAGTATTTG GTGGTATTAA AGATAGTACA

GTGGATAACT TCGTGAGAAT TCGTCCAAAT GATCAAGAAG TAGTCACACC AACGACCGAA

GGCTTCATCA GTGTGCCAAC CTTCGACTTC GGCCAAGTGG GCGTTGCAGG AACTAAGCAA

CAACACAGCT TGAAACAAGC CGCGGATTAC TACGGTAACG GCACACGGAA TCCGTATCTG

CGGATTAAGA AAACGCAACC CAATTGGAGC TTAACAGCGC AACTGTCACA ACCAAAATCA

GCGACAGACA GCTTGCCTAC AGCGACCCGC TTATTATTAG GGGCGGCGCC TGTCTCTAGC

TTTACCAATT ACAATCAACC AACCGAGTTG AAAAATACGG TCGGTACCAC GAGTGCCATT

AGCTTAACAG CCAACAACAC AGCAACGAGT ATTATTGCCA ACAAGCAATT CACAGGTAGT

AATGTTTATC AGTTGGACTT CACCTTCAAT AATGTCAAAC TTGAAGTGCC AGCCAATCAA

GGTGTTAAAG GGCAACAATA CAAGGCCGCA GTTACATGGA ACCTAGTTAC AGGTCCTTAA

EF108-2 (SEQ ID NO:418)

MKQTKWQ RLATIGLCSS LVINAFSGVT AVAETVTTES SPTAESSAKE

ETQASSVKEE TTKASTENSQ VTTDTSQEEA TKEAEKEEPQ AEVEQAETPI IPKPKKINMK

ATYSFSAETY QFGFVNESGQ LINPDIIPIT YSYAKGSWKT DGYNRKWTSM VQGSASTVGN

LKNVIMPATS VVMPPGPSYE GTQEVYTNFS TRIPKYYASA SLYNREGKID STYPLPAIAL

AGTRPLSLTQ SSVISALALT SKGDNVYTPR ETFFGGDPAG VKFTNFLYRI NDFDVKGNNI

GYKTVSSPIY YHLTNRRVTE NFVDTSGAKI TPPSNFTQGK QTVLNSDPYT FQQSGFLPET

YKVGTKSYRF KCWYKGKTKT EPLATTKTPS YKVTYDDNDD LTVVYEEFSG YELPASTNQF

GFVDEATNKL IAPDQVQMKY NLTLNENNKK TVMSSNLTGT DTATLKNLSV PVNYFEQYRV

NTFYGASDIT FTLPKRYKSI NITKSDGKTD PAFPLPKIYN IDQVEMSHNP VTTYNKLKQL

SGQTFGFNAL ADQPEFYTKT LFGTESGIDD PVNYYTMSGP VYYYLENRKV TENFVDTNGA

KITPPTGFTQ GKKTVITSDA YTFKQAGTLP DTYTTGGKTY KFKGWYKGKS TLNTLTTTKA

PSYQVTYDDN DDLNVVYEEE TVTTVYPSVD MNFVNEKGGA FTPALTFSGK YYAQSTSAYL

RTDLYDVTSK NNGNGQYTVS INNGSMPLSQ ELLKKYNNGQ PISATNRLQF NVDKLAIDQQ

LKYVDSIQLD TAQSSNLKSY RYVYTNNSSL VFDPNVAPAE VDLSSESLNL LNFDSDGTYF

SNANNRLFYT HLGYSGTPGV NYLLVMFLFN AKPADKSKLV YKVTRKQVTE NFVDVNGAKI

TAPTGFTQGN QVPMNSNTFK YTAAKALPAT YTTGOKVYTF QGWYKGKTKP STLNKTTTPT

FNATFDGNDD MTAMYKEEIP TASVTLTRPK EVIDTNTNVI WTTTITNTSK APLQNLTLKK

GPNWSAGLTI PTFMEVTPEC ETTKSIPVNS TLWTEGVPLP NAVPTGKKVS VAFTTEATGK

PNTVLKAEVV VFGGIKDSTV DNFVRIRPND QEVVTPTTEG FISVPTFDFG QVGVAGTKQQ

HSLKQAADYY GNGTRNPYLR IKKTQPNWSL TAQLSQPKSA TDSLPTATRL LLGAAPVSSF

TNYNQPTELK NTVGTTSAIS LTANNTATSI IANKQFTGSN VYQLDFTFNN VKLEVPANQG

VKGQQYKAAV TWNLVTGP

EF108-3 (SEQ ID NO:419)

CGT GACGATTGAA AGTAGTCCGA CCGCCGAAAG TAGTGCCAAG

GAAGAGACGC AAGCAACTAG CGTGAAGGAA GAAACAACGA AAGCCAGTAC GGAAAATAGT

CAAGTAACAA CTGACACGAG TCAGGAAGAA GCAACGAAAG AACCCCACAA AGAAGAACCG

CAAGCACAAG TGGAACAAGC AGAAACACCA ATCATTCCTA AACCAAAAAA AATCAATATG

AAGGCAACTT ATTCATTTTC TGCAGAAACT TATCAGTTTG GATTTGTGAA TGAATCAGGT

CAATTAATAA ATCCAGATAT TATACCAATT ACGTATAGCT ATCCCAAAGG ATCATGGAAG

ACAGATGGTT ATAATCGAAA GTGGACTAGT ATGGTTCAAG GGAGTGCTTC AACCGTAGGA

AACTTAAAGA ATCTAATAAT GCCACCAACT TCTGTACTTA TGCCACCAGG ACCOTCATAT

GAAGGAACTC AAGAGGTGTA CACAAACTTT TCAATTCGCA TACCAAAATA TTATGCATCA

CCGAGTCTCT ACAATAGAGA AGCTAAAATT GATTCTACTT ATCCGTTACC TGCTATTGCA

CTAGCAGGTA CTAGACCGCT ATCTTTGACT CAAAGTAGTG TAATTACTGC ATTGGCGCTG

ACCAGTAAAG GAGACAATGT TTATACACCA CGGGAAACAT TTTTTGGAGG AGATCCTGCA

GGTGTAAAGT TTACTAATTT TTTGTATCGT ATAAATCACT TTGATGTGAA AGGTAATAAC

ATAGOTTATA AGACTOTOAG TAGCCCAATC TATTACCATO TGACCAACCG CCGTGTCACC

GAAAACTTCG TAGATACAAG TGGCGCCAAA ATCACGCCAC CAAGTAATTT CACCCAAGCG

AAACAAACGG TCATTAACAG TGATCCTTAC ACGTTCCAAC AAAGTCCTTT TTTACCCGAG

ACCTACAAAG TTGGCACGAA ATCTTACCCA TTCAAAGGCT GGTACAAAGG GAAAACCAAA

ACCGAGCCTT TOOCCACCAC TAAAACACCT AGCTATAAAG TCACGTATGA TGACAATGAT

GATTTCACGG TGGTCTATGA GGAGTTTTCA GGGTACGAGC TGCCTGCTTC GACCAATCAA

TTTGGCTTTG TGGATGAAGC GACGAACAAA TTAATTGCCC CCGACCAAGT GCAGATGAAG

TATAATCTTA CTTTAAATCA AAATAATAAA AAAACAGTAA TGAGCAGTAA CTTAACGGGG

ACAGATACAC CGACACTGAA AAACTTGTCC GTGCCTGTCA ACTATTTTGA ACAATATCGC

CTCAATACGT TTTATGGCGC GAGTGACATT ACGTTTACAT TGCCCAAACG GTACAAATCA

ATCAATATTA CCAAATCAGA TGGCAAAACC GACCCAGCTT TTCCTCTTCC TAAAATCTAT

AATATAGATC AAGTAGAAAT GTCACACATG CCTGTGACCA CTTATAACAA GTTGAAACAG

CTGTCGGGCC AAACGTTTGG CTTTAATGCT TTAGCCCATC AACCTGAATT TTATACGAAA

ACGTTATTTG GGACAGAGTC TGGCATCGAT GACCCACTCA ATTATTATAC AATGAGTGGC

CCTGTTTACT ATTATTTAGA AAACCGCAAA GTCACCGAGA ACTTCGTAGA CACCAACGGC

GCTAAAATCA CACCGCCAAC AGGTTTCACC CAAGGTAAAA AAACGGTGAT TACAAGCCAC

GCCTACACTT TCAAACAAGC AGGCACCTTA CCAGACACTT ACACAACAGG CGGTAAGACC

TACAAGTTCA AAGGTTGGTA CAAAGGCAAG TCCATACTCA ACACATTGAC AACTACCAAA

GCGCCAAGTT ATCAAGTGAC CTACGATGAC AATGATCATT TGAATGTGGT GTATGAAGAA

GAAACAGTTA CGACAGTGTA TCCATCAGTC GATATGAACT TTGTGAATGA AAAACCCGCC

GCTTTCACAC CGGCGTTAAC TTTTAGTGGT AAGTACTATG CGCAAAGTAC GAGTGCGTAC

TTAAGAACCG ATTTATATGA CGTGACCTCA AAAAATAATG GTAATGGGCA ATATACGGTA

AGTATTAATA ATGGTAGTAT GCCATTGTCC CAAGAATTAT TGAAAAAATA TAATAATGGA

CAACCAATCA GTGCTACCAA CAGATTACAG TTTAATGTTG ATAAATTAGC CATCGACCAA

CAACTAAAAT ATGTTGACAG CATTCAATTA GACACAGCTC AAAGTAGCAA TCTGAAATCC

TATAGATATG TGTACACGAA CAATAGCTCA CTGGTTTTCG ACCCAAATGT AGCACCAGCA

GAGGTTGACC TTAGTTCAGA ATCTCTTAAC TTGCTTAATT TTGATTCAGA TGGCACCTAT

TTTTCTAATG CAAATAATAG ACTTTTTTAC ACGCATTTAG GATATAGTGG CACACCAGGA

GTTAACTATC TTCTCGTAAT GTTTCTTTTT AACGCCAAAC CTGCGGATAA GTCAAAACTT

CTCTACAAAG TCACTCGCAA ACAAGTCACC GAAAACTTCG TGGATGTCAA CGGTGCCAAA

ATCACTGCAC CAACAGGCTT CACCCAAGGT AACCAAGTAC CAATGAACAG TAACACCTTC

AAGTACACAG CGGCAAAAGC TTTACCAGCG ACGTATACTA CAGGTGGCAA AGTCTATACG

TTCCAAGGGT GGTATAAAGG GAAAACCAAG CCAAGTACGT TGAACAAAAC AACAACTCCA

ACGTTCAATG CGACCTTTGA TGGCAATGAC GATATGACCG CCATGTATAA GGAAGAAATA

CCAACAGCTA GTGTCACATT AACTCGACCA AAAGAAGTGA TTGATACGAA TACCAATGTA

ATCTGGACAA CAACGATCAC GAATACTAGC AAAGCACCCT TACAAAATCT CACCTTGAAA

AAAGGGCCCA ATTGGTCAGC TGGTCTGACG ATCCCGACCT TTATGGAAGT GACACCAGAA

GGAGAAACGA CAAAATCAAT CCCAGTAAAT AGTACACTTT GGACAGAGGG GGTTCCTTTA

CCAAATGCCC TTCCTATCGG CAAAAAAGTT TCAGTTGCTT TCACAACTCG CGCAACAGGG

AAACCAAACA CTGTTTTGAA AGCAGAAGTT GTAGTATTTG GTGGTATTAA AGATAGTACA

GTGGATAACT TCGTGAGAAT TCGTCCAAAT GATCAAGAAG TAGTCACACC AACGACCGAA

GGCTTCATCA GTGTGCCAAC CTTCGACTTC GGCCAAGTGG GCGTTGCAGG AACTAAGCAA

CAACACAGCT TGAAACAAGC CGCGGATTAC TACGGTAACG GCACACGGAA TCCGTATCTG

CGGATTAAGA AAACGCAACC CAATTGGAGC TTAACAGCGC AACTGTCACA ACCAAAATCA

GCGACAGACA GCTTGCCTAC AGCGACCCGC TTATTATTAG GGGCGGCGCC TGTCTCTAGC

TTTACCAATT ACAATCAACC AACCGAGTTG AAAAATACGG TCGGTACCAC GAGTGCCATT

AGCTTAACAC CCAACAACAC AGCAACGAGT ATTATTGCCA ACAAGCAATT CACAGGTAGT

AATGTTTATC AGTTGGACTT CACCTTCAAT AATGTCAAAC TTGAAGTGCC AGCCAATCAA

GCTGTTAAAG GGCAACAATA CAAGGCCGCA GTTACATGGA ACCTAGTTAC AG

EF108-4 (SEQ lED NO:420)

VTIES SPTAESSAKE

ETQASSVKEE TTKASTENSQ VTTDTSQEEA TKEAEKEEPQ AEVEQAETPI IPKPKKINMK

ATYSFSAETY QFGFVNESGQ LINPDIIPIT YSYAKGSWKT DGYNRKWTSM VQGSASTVGN

LKNVIMPATS VVMPPGPSYE GTQEVYTNFS IRTPKYYASA SLYNREGKTD STYPLPAIAL

AGTRPLSLTQ SSVISALALT SKGDNVYTPR ETFFGGDPAG VKFTNFLYRI NDFDVKGNNI

GYKTVSSPIY YHLTNRRVTE NFVDTSGAKI TPPSNFTQGK QTVTNSDPYT FQQSGFLPET

YKVGTKSYRF KCWYKGKTKT EPLATTKTPS YKVTYDDNDD LTVVYEEFSC YELPASTNQF

GFVDEATNKL IAPDQVQMKY NLTLNENNKK TVMSSNLTGT DTATLKNLSV PVNYFEQYRV

NTFYGASDIT FTLPKRYKST NTTKSDGKTD PAFPLPKIYN IDQVEMSHMP VTTYNKLKQL

SGQTFGFNAL ADQPEFYTKT LFGTESGIDD PVNYYTMSGP VYYYLENRKV TENFVDTNGA

KITPPTGFTQ GKKTVTTSDA YTFKQAGTLP DTYTTGGKTY KFKGWYKGKS ILNTLTTTKA

PSYQVTYDDN DDLNVVYEEE TVTTVYPSVD MNFVNEKGGA FTPALTFSGK YYAQSTSAYL

RTDLYDVTSK NNGNGQYTVS INNGSMPLSQ ELLKKYNNGQ PTSATNRLQF NVDKLAIDQQ

LKYVDSIQLD TAQSSNLKSY RYVYTNNSSL VFDPNVAPAE VDLSSESLNL LNFDSDGTYF

SNANNRLFYT HLGYSGTPGV NYLLVNFLFN AKPADKSKLV YKVTRKQVTE NFVDVNGAKI

TAPTGFTQGN QVPMNSNTFK YTAAKALPAT YTTGGKVYTF QGWYKGKTKP STLNKTTTPT

FNATFDGNDD MTAMYKEEIP TASVTLTRPK EVIDTNTNVI WTTTITNTSK APLQNLTLKK

GPNWSAGLTI PTFMEVTPEG ETTKSIPVNS TLWTEGVPLP NAVPIGKKVS VAFTTRATGK

PNTVLKAEVV VFGGIKDSTV DNFVRTRPND QEVVTPTTEG FTSVPTFDFG QVGVAGTKQQ

HSLKQAADYY GNGTRNPYLR IKKTQPNWSL TAQLSQPKSA TDSLPTATRL LLGAAPVSSF

TNYNQPTELK NTVGTTSAIS LTANNTATSI IANKQFTGSN VYQLDFTFNN VKLEVPANQG

VKGQQYKAAV TWNLVT

EF109-1 (SEQ ID NO:421)

AGGAGTAAAT TAATCAAAAA AAGTGTTATA ACTAGTTCTA TOTTACCOOT TTTCTTGTCG

CCATTTCTCG TTACCCCTAT TTCTGCTTAC GCTTTGGAAC GCTCTAAGGG AACTACTGAA

GAAACGGTGG CTTCAGAAAC ATCTCTAACG GAGCGACAAA TGAGTAGCGG TGTCACTGAA

GAAATCAACC CAACCATCAT AAATTCTCAA GAGGAAACAG AAACAACGTC CACTTCCTCA

ACCTCCGATT CCACCACTGA AGTTTCTACA TCAGAAGTAA CAACTGTTAA TGATACAGAA

NATAGTAGCG ACGTACTGAA ACTACTTTGG NAACATCACN AACTAATCAG GACACACCTA

TAG

EF109-2 (SEQ ID NO:422)

MKKSVI TSSMLAVLLS GFLVTPISAY ALERSKGTTE ETVASETSLT ERQMSSGVTE

EHNPSIILNSQ EETETTSTSS TSDSTTEVST SEVTTVNDTE XSSDVLKLLW XHHXVMRTHL

EF109-3 (SEQ ID 110:423)

GGAAC GCTCTAAGGG AACTACTGAA

GAAACGGTGG CTTCACAAAC ATCTCTAACG GAGCGACAAA TGAGTACCCG TCTCACTCAA

GAAATGAACC CAAGCATCAT AAATTCTCAA GAGGAAACAG AAACAACGTC CACTTCCTCA

ACCTCCGATT CCACCACTGA AGTTTCTACA TCAG

EF109-4 (SEQ ID 140:424)

ERSKGTTE ETVASETSLT ERQMSSGVTE EMNPSIINSQ EETETTSTSS TSDSTTEVST S

EF110-1 (SEQ ID 140:425)

TAAATAAAAA TGGATAAGGA GTGGCATAAT CTTATGAAAA AGTTCTCCAT ACGAAAAATT

AGTGCTGGTT TTTTGTTTCT GATTTTAGTA ACTTTGATCG CCGGTTTTAG CTTGTCTGCA

AATGCAGAAG AGTATATCGT TCCTGCCGAA AGTCATTCAC GACAAAAAAG ATCGTTACTG

GACCCTGAGG ACAGAAGACA AGAAGTGGCA GATACAACCG AAGCGCCTTT TGCGTCAATC

GGAAGAATCA TTTCCCCTGC CAGTAAACCA GGCTATATTT CTTTAGGAAC AGGCTTTGTT

GTTGGAACCA ATACAATTGT CACCAATAAT CATGTGGCTG AAAGTTTTAA GAATGCCAAA

GTATTAAATC CGAATGCCAA AGATGATGCT TGGTTTTATC CAGGTCGAGA TGGCAGTGCG

ACACCATTTG GCAAATTCAA AGTGATTGAT GTAGCTTTTT CCCCGAATGC GGATATTGCG

GTAGTGACTG TCGGCAAACA AAACGATCGT CCAGATGGCC CAGAGTTGGG AGAAATTTTA

ACGCCATTTG TTTTGAAAAA GTTTGAATCT TCAGATACCC ATGTCACAAT ATCAGGCTAT

CCAGGTGAGA AAAACCACAC ACAATGGTCT CATGAAAATG ATTTGTTTAC ATCTAACTTT

ACAGACTTAG AAAATCCATT ACTATTTTAT GATATCGATA CAACCGGCGG TCAATCTGGT

TCACCAATCT ATAATGATCA GGTTGAAGTA GTTGGTGTTC ATTCCAATGG CGGCATTAAG

CAAACAGGAA ATCATGGTCA AAGACTAAAT GAAGTGAATT ATAACTTTAT TGTTAATCGA

GTGAATGAAG AAGAAAATAA ACGTTTATCC GCTGTGCCAG CAGCGTAA

EF110-2 (SEQ ID 140:426)

MKKFSIRKIS AGFLFLILVT LIAGFSLSAN AEEYIVPAES HSRQKRSLIJD

PEDRRQEVAD TTEAPFASIG RIISPASKPG YISLGTGFVV GTNTIVTNNH VAESFKNAKV

LNPNAKDDAW FYPGRDGSAT PFGKFKVIDV AFSPNADIAV VTVGKQNDRP DGPELGEILT

PFVLKKFESS DTHVTISGYP GEKNHTQWSH ENDLFTSNFT DLENPLLFYD IDTTGGQSGS

PIYNDQVEVV GVHSNGGIKQ TGNHGQRLNE VNYNFIVNRV NEEENKRLSA VPAA

EF110-3 (SEQ ID 140:427)

AG AGTATATCGT TCCTGCCGAA AGTCATTCAC GACAAAAAAG ATCGTTACTG

GACCCTGAGG ACAGAAGACA AGAAGTGGCA GATACAACCG AAGCGCCTTT TGCGTCAATC

GGAAGAATCA TTTCCCCTGC CAGTAAACCA GGCTATATTT CTTTAGGAAC AGGCTTTGTT

GTTGGAACCA ATACAATTGT CACCAATAAT CATGTGGCTG AAAGTTTTAA GAATGCCAAA

GTATTAAATC CGAATGCCAA AGATGATGCT TGGTTTTATC CAGGTCGAGA TGGCAGTGCG

ACACCATTTG CCAAATTCAA AGTGATTGAT GTAGCTTTTT CCCCGAATGC GGATATTGCG

GTAGTGACTG TCGGCAAACA AAACGATCGT CCAGATGGCC CAGAGTTGGG AGAAATTTTA

ACGCCATTTG TTTTGAAAAA GTTTGAATCT TCAGATACCC ATGTCACAAT ATCAGGCTAT

CCAGGTGAGA AAAACCACAC ACAATGGTCT CATGAAAATG ATTTGTTTAC ATCTAACTTT

ACAGACTTAC AAAATCCATT ACTATTTTAT GATATCGATA CAACCGGCGG TCAATCTGGT

TCACCAATCT ATAATGATCA GGTTGAAGTA GTTGGTGTTC ATTCCAATGG CGGCATTAAG

CAAACAGGAA ATCATGGTCA AAGACTAAAT GAAGTGAATT ATAACTTTAT TGTTAATCGA

GTGAATGAAG AAGAAAATAA ACGTTTATCC GCTGTGCCAG CAGCGT

EF110-4 (SEQ ID NO:428)

EYIVPAES HSRQKRSLLD

PEDRRQEVAD TTEAPFASTG RIISPASKPG YISLGTGFVV GTNTIVTNNH VAESFKNAKV

LNPNAKDDAW FYPGRDGSAT PFGKFKVIDV AFSPNADIAV VTVGKQNDRP DOPELGEILT

PFVLKKFESS DTHVTISGYP GEKNHTQWSH ENDLFTSNFT DLENPLLFYD IDTTGGQSGS

PIYNDQVEVV GVHSNGGIKQ TGNHGQRLNE VNYNFIVNRV NEEENKRLSA VPAA

EF111-1 (SEQ ID NO:429)

TGATCAATAC ACTTCGATAC GGTCGCTTTT TTTCTAGAGA AAGTTGAATC TTTCAATAAT

AAAAAGGGAT ACACTCCATT TGGCATAGTC CTTGCTGATA ATAAATCAGT GTATAAAGCG

CTATCATTTT ATAGGAGGGG TTTTATGAAG GGTTTATCAA AAAAGAAACG GGTGTCTACT

TGGTTAGCGT TAGGAATCAC CGTAGTCAGC TGTTTTGCGT TAAGCAGGGA AGTGCAAGCA

AGTGTTGAAA GAACAAAAGT TGATGAATTT GCAAATGTTT TAGATGTGAG TGCATCACCA

ACCGAACGGA CGAATGGCGT ATACGATACC AATTATTTTA ATAATTTTTC TGATTTAGGT

GCATGGCATG GCTACTATTT ACCTGAAAAA AGCAATAAAG AGCTACTGGG TGGTTTTGCG

GGGCCATTGA TTATTGCCGA AGAATATCCA GTAAACTTGG CCGCAAGTTT AAACAAATTA

ACGGTCAAAA ATAAAAAAAC GGGAGAAACC TATGATTTAA GCCAAAGCAA CCGCATGGAC

CTGTCTTATT ATCCTGGGCG CCTAGAGCAA ACCTATGAAT TAGACGATTT AACGATTCAT

TTAGCTTTAA TTTTTGTCAG CAATCGAACG GCGCTTATCC AAACGACACT TGAAAACACT

GGTGAAGAGC CCTTGTCACT TGGAGCAAGC TGGACAGGTG CGGTCTTTCA CAAAATTCAA

GAGGGAACGG AAACCTTAGA TATTGGCACT CGTTTAACTG CTAAAGACAA TGACATTCAA

GTGAATTTTG GTGAAGTCAG AGAAACGTGG AATTATTTTG CTACGAAAGA CACAAAATAT

ACGATTCATC ATGCGGATAA AGTTTCAACA AAAATTGATA ATCGGAATTA TACAGCAACC

GCTGAACCAA TTGAATTGAA GCCTAAACAA ACGTACAACA CCTATACGAC AGAAAGCTAT

ACTTTTACAA AAGAAGAAGA GGCAAAGGAA CAACAACAAG CACCCGAATA TACCAAAAAT

GCGGCGCGCT ATTTCAAAGA GAACAAGCAA AGATGGCAAG GATATCTAGA TAAAACGTTT

GATCAAAAGA AAACAGCAGA ATTTCCTGAA TATCAAAATG CGCTAGTCAA ATCGATTGAA

ACGATTAATA CCAATTGGCG AAGTGCGGCA GGTGCCTTTA AGCATGACGG GATTGTTCCG

TCCATGTCTT ATAAATGGTT TATTGGTATG TGGGCTTGGG ATTCGTGGAA AGCGGATGTA

GCAACGGCTG ATTTTAATCC TGAGTTAGCT AAAAATAATA TGCGGGCCTT GTTTGATTAT

CAAATTCAAA AAGATGATAC CGTACGTCCA CAAGATGCAG GAGCGATCAT TGATGCTGTC

TTTTACAATC AAGACAGTGC GCGTGGTGGT GAAGGTGGCA ACTGGAATGA ACGAAATTCT

AAACCACCAT TGGCTCCATG GGCAGTTTGG CATATTTATC AAGAAACCAA AGATAAGGAA

TTTTTAAAAG AAATGTATCC CAAACTTGTG GCTTATCATA ATTGGTGGTA TACCAACAGA

GACCACAATA AAAATCGGAT AGCAGAATAT GGAAGCATGG TCAGTGATGC TCACTGGCAA

AAAGACGACA AGGATCAAAT CATTAAAGAT AAAAATGGCC ACCTAAAGTG GATGATGATG

CTGTTATTGA AGCAGCCGCG TGGGAAAGTG GCATGGATAA CGCTACACGG TTTGACAAAG

AAGGTGTGGG CAAAGGCGAC GTTGGAGTTA AAGTTTTTGA AAACAAAAAT AAAGGAAAAG

TAG

EF111-2 (SEQ TD NO:430)

MKG LSKKKRVSTW

LALGITVVSC FALSREVQAS VERTKVDEFA NVLDVSASPT ERTNGVYDTN YFNNFSDLGA

WHGYYLPEKS NKELLGGFAG PLIIAEEYPV NLAASLNKLT VKNKKTGETY DLSQSNRMDL

SYYPGRLEQT YELDDLTIHL ALTFVSNRTA LIQTTLENTG EEPLSLGASW TGAVFDKTQE

GTETLDIGTR LTAKDNDIQV NFGEVRETWN YFATKDTKYT IHHADKVSTK IDNRNYTATA

EPIELKPKQT YNTYTTESYT FTKEEEAKEQ QQAPEYTKNA ARYFKENKQR WQGYLDKTFD

QKKTAEFPEY QNALVKSIET INTNWRSAAG AFKHDGIVPS MSYKWFIGMW AWDSWKADVA

TADFNPELAK NNMRALFDYQ TQKDDTVRPQ DAGATIDAVE YNQDSARGGE GGNWNERNSK

PPLAAWAVWH TYQETKDKEF LKEMYPKLVA YHNWWYTNRD HNKNGIAEYG SMVSDAHWQK

DDKDQIIKDK NGHLKWMMML LLKQPRGKVA WITLHGLTKK VWAKATLELK FLKTKIKEK

EF111-3 (SEQ ID NO:431)

TGATGAATTT GCAAATGTTT TAGATGTGAG TGCATCACCA

ACCGAACGGA CGAATGGCGT ATACGATACC AATTATTTTA ATAATTTTTC TGATTTAGGT

GCATGGCATG GCTACTATTT ACCTGAAAAA AGCAATAAAG AGCTACTGGG TGGTTTTGCG

GGGCCATTGA TTATTGCGGA AGAATATCCA GTAAACTTGG CGGCAAGTTT AAACAAATTA

ACGGTCAAAA ATAAAAAAAC GGGAGAAACC TATGATTTAA GCCAAAGCAA CCGCATGGAC

CTGTCTTATT ATCCTGGGCG CCTAGAGCAA ACCTATGAAT TAGACGATTT AACGATTCAT

TTAGCTTTAA TTTTTGTCAG CAATCGAACG GCGCTTATCC AAACGACACT TGAAAACACT

GGTGAAGAGC CCTTGTCACT TGGAGCAAGC TGGACAGGTG CGGTCTTTGA CAAAATTCAA

GAGGGAACGG AAACCTTAGA TATTGGCACT CGTTTAACTG CTAAAGACAA TGACATTCAA

GTGAATTTTG CTGAAGTCAG AGAAACCTCG AATTATTTTG CTACGAAAGA CACAAAATAT

ACGATTCATC ATGCGGATAA AGTTTCAACA AAAATTGATA ATCGGAATTA TACAGCAACC

GCTGAACCAA TTGAATTGAA GCCTAAACAA ACGTACAACA CCTATACGAC AGAAAGCTAT

ACTTTTACAA AAGAAGAAGA GGCAAAGGAA CAACAACAAG CACCCGAATA TACCAAAAAT

GCGGCGCGCT ATTTCAAAGA GAACAAGCAA AGATGGCAAG GATATCTAGA TAAAACGTTT

GATCAAAAGA AAACAGCAGA ATTTCCTGAA TATCAAAATG CGCTAGTCAA ATCGATTGAA

ACGATTAATA CCAATTGGCG AAGTGCGGCA GGTGCCTTTA AGCATGACGG GATTGTTCCG

TCCATGTCTT ATAAATGGTT TATTGGTATG TGGGCTTGGG ATTCGTGGAA AGCGGATGTA

GCAACGGCTG ATTTTAATCC TGAGTTAGCT AAAAATAATA TGCGGGCCTT GTTTGATTAT

CAAATTCAAA AAGATGATAC CGTACGTCCA CAAGATGCAG GAGCGATCAT TGATGCTGTC

TTTTACAATC AAGACAGTGC GCGTGGTGGT GAAGGTGGCA ACTGGAATGA ACGAAATTCT

AAACCACCAT TGGCTGCATG GGCAGTTTGG CATATTTATC AAGAAACCAA AGATAAGGAA

TTTTTAAAAG AAATGTATCC CAAACTTGTG GCTTATCATA ATTGGTGGTA TACCAACAGA

GACCACAATA AAAATGGGAT AGCAGAATAT GGAAGCATGG TCAGTGATGC TCACTGGCAA

AAAGACGACA AGGATCAAAT CATTAAAGAT AAAAATGGCC ACCTAAAGTG GATGATGATG

CTGTTATTGA AGCAGCCGCG TGGGAAAGTG GCATGGATAA CGCTACACGG TTTGACAAAG

AAGGTGTGGG CAAAGGCGAC GTTGGAGTTA AAGTT

EF111-4 (SEQ ID NO:432)

DEFA NVLDVSASPT ERTNGVYDTN YFNNFSDLGA

WHGYYLPEKS NKELLGGFAG PLIIAEEYPV NLAASLNKLT VKNKKTGETY DLSQSNRMDL

SYYPGRLEQT YELDDLTIHL ALIFVSNRTA LIQTTLENTC EEPLSLGASW TGAVFDKIQE

GTETLDIGTR LTAKDNDIQV NFGEVRETWN YFATKDTKYT IHHADKVSTK IDNRNYTATA

EPIELKPKQT YNTYTTESYT FTKEEEAKEQ QQAPEYTKNA ARYFKENKQR WQGYLDKTFD

QKKTAEFPEY QNALVKSTET INTNWRSAAG AFKHDGIVPS MSYKWFTGMW AWDSWKADVA

TADFNPELAK NNMRALFDYQ IQKDDTVRPQ DAGAIIDAVE YNQDSARGGE GGNWNERNSK

PPLAAWAVWH IYQETKDKEF LKEMYPKLVA YHNWWYTNRD HNKNGIAEYG SMVSDAHWQK

DDKDQIIKDK NGHLKWMMML LLKQPRGKVA WITLHGLTKK VWAKATLELK

SF117-1 (SEQ ID NO:433)

TAATTCGATG GAGAAGGTGG TTTAGTGAAA AGATTTTCAT TTTTTTTACT AATTTTACTT

GCTTTAACAG GTTGTAAATC CGGTGAAAAA GAATTTGATG AAGAATCTCT TCAAAATCTA

AAGGAAACGN CACAGTCTTA NTCAGAAACA GAATTACAAA ATGGTGACGT TCGTTTAAAT

GAATATATTT CTTTGAAAGG GGAGATTGTT GAGAGTGACA GTCGTTCCAG TTTAATAAAA

AAAGGTGATC GTTTTATTTT GAAAAGTGGT TCTAGTAAAT ATCAAGTTTN TAATGAGCAA

AAGAAAAAAT TGAAGATTGG TGACGAAGTG ACAGTTTACG GAGAATATTA CGGCTTTTTG

AAAGGCACAT TAATTGAAAG TGAGGAGAAT CATGATTCAG CCACGAATTA C

EF117-2 (SEQ ID NO:434)

VKR FSFFLLILLA LTGCKSGEKE FDEESLQNLK ETXQSXSETE LQNGDVRLNE

YISLKGEIVE SDSRSSLIKK GDRFILKSGS SKYQVXNEQK KKLKIGDEVT VYGEYYGFLK

GTLIESEENH DSATN

EF117-3 (SEQ ID NO:435)

TG AAGAATCTCT TCAAAATCTA

AAGGAAACGN CACAGTCTTA NTCAGAAACA GAATTACAAA ATGGTGACGT TCGTTTAAAT

GAATATATTT CTTTGAAAGC GGAGATTGTT GACAGTGACA GTCCTTCCAG TTTAATAAAA

AAAGGTGATC GTTTTATTTT GAAAAGTGGT TCTAGTAAAT ATCAAGTTTN TAATGAGCAA

AAGAAAAAAT TGAAGATTGG TGACGAAGTG ACAGTTTACG GACAATATTA CGGCTTTTTG

AAAGGGACAT TAATTGAAAG TGAGGAGAAT CATGATTCAG CCACGAA

EF117-4 (SEQ ID NO:436)

EESLQNLK ETXQSXSETE LQNGDVRLNE YISLKGEIVE SDSRSSLIKK GDRFILKSGS

SKYQVXNEQK KKLKIGDEVT VYGEYYGFLK GTLIESEENH DSATN

EF118-1 (SEQ ID NO:437)

TGAGGGGGAA AAAGTGTGTT AAAAAGAAAA GTGGGGATTG TCGCAGGCCT TTTCTGTTCA

GCTTTGTTAC TGACAGGTTG TGGCAAAAGT GCGAAAGATG AGTTCATTCA AGGAATCGGC

AATCANAACG CACAAGAATC TGGGGTTTGN GATTTCTCTA TGTCAATTAG TGACATGAAA

TTTTCACAAG AAGATGGTGC ACAAACGAAT CCTATGATTG GGATGCTCAT CACGCAAATC

AAAGACGCAT CGCTTTCTGG GGAAGATTCA AGTAGATGCC AAAAAAGAAA AAGCATTCAA

CTTAGACATC AAATTAAAAG CGATCGCAAT GGATCTACCG ATTTCATTGG TTGGATCGTT

AGATAA

EF118-2 (SEQ ID NO:438)

VLKRKV GIVAGVFCSA LLLTGCGKSA KDEFIQGIGN XNAQESGVXD FSMSISDMKF

SQEDGAQTNP MIGMLITQIK DASLSGEDSS RCQKRKSIQL RDETKSDGNG CTDFIGWIVR

EF118-3 (SEQ ID NO:439)

GAAAGATG AGTTCATTCA AGGAATCGGC

AATCANAACG CACAAGAATC TGCGGTTTGN GATTTCTCTA TGTCAATTAG TGACATGAAA

TTTTCACAAG AAGATGGTGC ACAAACGAAT CCTATGATTG GGATGCTCAT CACGCAAATC

AAAGACGCAT CGCTTTCTGG GGAAGATTCA AGTAGATGCC AAAAAAGAAA AAGCATTCAA

CTTAGAGATG AAATTAAAAG CGATGGGAAT GGATGTACCG ATTTCATTGG TTGGATCGTT

AGAT

EF118-4 (SEQ ID NO:440)

KDEFIQGIGN XNAQESGVXD FSMSISDMKF SQEDGAQTNP MIGMLITQIK DASLSGEDSS

RCQKRKSIQL RDEIKSDGNG CTDFIGWIVR

EF119-1 (SEQ ID NO:441)

TAAAGAATAC CGAGTAAAAT TTTCGGAAGG CTTTTTTTCA AAAATTGTAT ATGCAAAAGA

AGTGCAACGG AAAGGAGCTC GGAAATCGTG AATAAGCTAC CTTTACTTAT TTTATTGTTA

GGCGCAGTGT TGCTTGTTAG TGGCTGTCAA AGCCATAAGG AAGAAAACAA GTCTAGTAAA

GTATCGACAG AAGAAACGAC AGTGATTGAA ACAGTAGCAA GGGAACAATC GAAGGAATCG

TTTACGAGTG AAGCAACTAA AAAACAGACA GAAACAACGA AATTAGAAGA ACCAGATCAT

GTAAAACTTC TAGAAGCTTA TGGAAATGCG TATGCGAACT TTACAAGTAT TAATGATCGC

AATGAAAAGC TAAAGCCCCT CATGACTGAA AAATGTATCA AAAAAAATGG AATTGATGTT

AAAACTGGAG TAGCGTTAGT TTCCGTAGGA AAGGTTACAA CGATTTATAA AAATGATCAA

CATGAATATG CTTTACTTTT GGATTGTGAA CAAAATCGAA CGCAGACACG AGTCTTACTT

TTGGCTAAGG TCAAGAACAA TAAAATTTCT GAAATGACCT ATAATTCAGT TAAGCAAGAG

TATTAG

EF119-2 (SEQ ID NO:442)

VN KLPLLILLLG GVLLVSGCQS HKEENKSSKV STEETTVIET VAREQSKESF TSEATKKQTE

TTKLEEPDHV KLLEAYGNAY ANFTSINDRN EKLKPILMTEK CIKKNGIDVK TGVALVSVGK

VTTIYKNDQH EYALLLDCEQ NGTQTRVLLL AKVKNNKISE MTYNSVKQEY

EF119-3 (SEQ ID NO:443)

AGAAAACAA GTCTAGTAAA

GTATCGACAC AAGAAACGAC AGTGATTGAA ACAGTAGCAA GGGAACAATC GAAGGAATCG

TTTACGAGTG AAGCAACTAA AAAACAGACA GAAACAACGA AATTAGAAGA ACCAGATCAT

GTAAAACTTC TAGAAGCTTA TGGAAATGCG TATGCGAACT TTACAAGTAT TAATGATCGC

AATGAAAAGC TAAAGCCCCT CATGACTGAA AAATGTATCA AAAAAAATGG AATTGATGTT

AAAACTGGAG TAGCGTTAGT TTCCGTAGGA AAGGTTACAA CGATTTATAA AAATGATCAA

CATGAATATG CTTTACTTTT GGATTGTGAA CAAAATGGAA CGCAGACACG AGTGTTACTT

TTGGCTAAGG TGAAGAACAA TAAAATTTCT GAAATGACCT ATAATTCAGT TAAGCAAGAG

TAT

EF119-4 (SEQ ID NO:444)

ENKSSKV STEETTVIET VAREQSKESF TSEATKKQTE TTKLEEPDHV KLLEAYGNAY

ANFTS INDRN

EKLKPLMTEK CIKKNGIDVK TGVALVSVGK VTTIYKNDQH EYALLLDCEQ NGTQTRVLLL

AKVKNNKI SE MTYNSVKQEY

EF120-1 (SEQ ID NO:445)

TGAATAGGCG TGAAAAAGGG AATGTTAGCG TTTTTTGTCG TGCTAGCGGT TTTATCATTA

ACTGCTTGTC GGGAACCAAA AGNAAAGAAA GTAACCGCTT CAACGGAGGC ATCCTCTAAA

GTTGAAGAGA CGAATGAAAA AACGAGTGAA ACAATTGATA AGACAAACGA ACAAGCGAGC

AGCAGTGTCG AGTCTAACGA ATCAGTGAAA AATGAAGAGC CGACAGCTGA TGGAAACAAT

AGTCAGCTAA CTGTAGCTGA TTTAGATACT ACAGCGATTA ATGCTGGCGA TTTTACTACT

TTAGTTGGAA TATGGAAAAA TGGTAAAGGA GAGAGTTTGA TCATTCATCC TGATGGTAGT

ACAAATACCG GAGGAATGAT TACGAAGGAT TCACCTACTG ATGAGTCGCG ACCAATTACA

AGCTTAAGTA TTAGGTGGGG GCCTACTGGT GCTGCGCTAT TATTATATAA AATTGGTGTT

EF120-2 (SEQ ID NO:446)

VKKGMLAF FVVLAVLSLT ACREPKXKKV TASTEASSKV EETNEKTSET IDKTNEQASS

SVESNESVKN EEPTADGNNS QLTVADLDTT AINAGDFTTL VGIWKNGKGE SLIIHPDGST

NTGGMITKDS PTDESRPITS LSIRWGPTGA ALLLYKIGV

EF120-3 (SEQ ID NO:447)

AAGAAA GTAACCGCTT CAACGGAGGC ATCCTCTAAA

GTTGAAGAGA CGAATGAAAA AACGACTGAA ACAATTGATA AGACAAACGA ACAAGCGAGC

AGCAGTGTCG AGTCTAACGA ATCAGTGAAA AATGAAGAGC CGACAGCTGA TGGAAACAAT

AGTCAGCTAA CTGTACCTGA TTTAGATACT ACAGCGATTA ATGCTGCCGA TTTTACTACT

TTAGTTGGAA TATGGAAAAA TGGTAAAGGA GAGAGTTTGA TCATTCATCC TGATGGTAGT

ACAAATACCG GAGGAATGAT TACGAAGGAT TCACCTACTG ATGAGTCGCG ACCAATTACA

AGCTTAAGTA TTAGGTGGGG GCCTACTGGT GCTGCGCTAT TATTATATAA AATTGGTGTT

EF120-4 (SEQ ID NO:448)

KKV TASTEASSKV EETNEKTSET IDKTNEQASS

SVESNESVKN EEPTADGNNS QLTVADLDTT AINAGDFTTL VGIWKNGKGE SLIIHPDGST

NTGGMITKDS PTDESRPITS LSIRWGPTGA ALLLYKIGV

EF121-1 (SEQ ID NO:449)

TGAAACACAA GGAGGAAATT TGTGAAAAAG TTGAGCTTTA AAAAAGTGAA GTGGGGCATG

CATTTTTTAA TGGCTGTTGC GTTGATAGCG CCAAGTGTTA CTAGTACGGC ATATGCAGTA

GAAACAACGA GTCAACAAAG TTCAGAAGCA GTAACAAGTA CCACCGATTC AAGTAGAAAA

CAAGAACCAG TCATTACACA GGAAACAACA GACATCAAAC AAGAAGCACC AAATCAGGCT

ACGAGTCACA GTGTCAAGCA GTCACAAGAA ACCACAGCAC CAACAGAGAC GACGAATTTA

GAAACGTCAA TCGCTGAAAA AGAAGAAACG AGCACGCCGC AAAAAATAAC AATTTTAGGT

ACGTCAGATG TTCATGGTCA ATTATGGAAT TGGTCTTATG AAGATGATAA AGAACTACCA

GTTGGTTTGT CCCAAGTAAG TACAGTCGTT AACCAAGTCC GGGCACAAAA CCCAGCAGGC

ACCGTTTTAA TTCATAATGG CGACAATATT CAAGGCACTA TTTTAACAGA TGACTTGTAT

AATAAAGCGC CTTTAGTGAA TGAAAAGACC CATCCAATGA TCACCGCCAT GAATGTGATG

AAGTATGATG CAATGCTTTT GGGAAATCAT GAGTTTAATT TTGGTTTACC GTTAATCAAA

AAAATTCAAC AAGAAGCCAC TTTTCCAATC TTGTCTGCGA ATACCTACAA TAAGGAAGAT

GGTCTTCCTT TTGTTGAAGG GACTACCACG AAGGAACTTG ATTTTAATCA AGATGGGCAG

CCAGATTTAA AAGTTGGGAT TATCGGCTTA ACAATTCCGC ACATTCCTTT GTGGGATGGC

CCTCGTGTTA CTTCGCTTAA TTTTTTACCT TTGAAAGAAG AAGCAGAAAA AGCAGTTACT

GAGTTGAAAG CTAACGATCA GGCTGACATT ATTGTTGCCT CGATTCATGC GGGACAACAA

AATAGTGATC CGGCTGCCAG TGCCGACCAA GTAATTGAAA ATGTCGCGGG GATTGATGCG

TATATTCTGG GTCATGACCA CCTTTCTTTT ACCAAGCAAG GAGCAGCGCC GAATGGAAAA

ACTGTACCGG TAGGGGGACC GAAAGATACG GGGACAGAAG TTGTCAAAAT TGATCTTTCA

GTTGCTAAAA ATGCCGATAA GTGGGAAGTG CAAGAAGGTA CAGCAACGAT TGTACCAACA

ACGAATGTTC CAGCAGATGA AGCAGTTAAG GCAGCGACAA AAGAATACCA TGAAAAAACG

CGAGCGTTTA TTCAGGAGGA GATCGGCACA GCAACAGCTG ATTTTTTACC AAAACAAGAA

ATTAAAGGAA TTCCCGAAGC ACAATTACAA CCAACAGCGA TGATTTCTTT AATTAATAAC

GTTCAAAAAG AAGTAACGGG CGCACAATTA AGTGCGGCAG CGCTGTTTAA ATACGACAGT

AAATTACCTG CGGGGAAGAT TTCCTATGCC ACGATTTTTG ATATCTACAA ATACCCGAAT

ACCTTAGTGA GTGTTCCCAT TAACGGTGAA AACTTACTGA AGTATTTACA AAAACAAGCG

GCGTACTATA ACCAAACACA GCCAGATGAT TTGACCATTA CTTTTAATCC AAACATTCGT

GTATATAACT ATGACATGAT TTCTGGAGTG GACTACAAGA TTGACATTTC AAAACCAGTG

GGTCAACGAA TTGTAGATGC GAAAATTGAC GGCCAACCCC TGGATCCTGC CAAAGAATAT

ACGATTGCTA TGAATAATTA TCGTTACGGC GGTTTAGCTA GCCAAGGGAT TCAAGTAGGG

GAACCTATTA AAAATTCTGA TCCAGAAACC TTACGAGGAA TGATTGTTGA TTATATTAAG

AAAAAAGGAA CTCTTGATCC AGAACAACAA ATCGAACGAA ATTGGTCAAT TATTOGGACA

AATTTTGATG AAAAATGGCG TGCCAAAGCA ATCGAATTAG TGAATGACGG CACTCTTCAA

ATTCCGACTT CTCCTGATGG ACGTACACCA AACGCCGCCG CTATTACGAA ACAAGATGTC

CGTAATGCGG GCTTTGATTT AGATAATGCA TATACCATTA TGCACACAAA TGACGTTCAT

GGCCGACTAG AAGCAGGGAA AGGCGAATTA GGTATGGCGC GTCTAAAAAC CTTTAAAGAC

CAAGAAAACC CAACCTTGAT GGTGGATGCA GGGGATGTTT TCCAAGGATT ACCAATCTCC

AATTTCTCCA AAGGCGCGGA TATGGCCAAA GCAATGAATG AAGTTGGTTA TGATGCCATG

GCGGTGGGAA ATCACGAGTT TGATTTTGGT TTAGAGATTG CACTAGGTTA TAAAGACCAA

CTGAATTTTC CGATTTTATC TAGTAATACG TATTACAAAG ATGGCAGTGG ACGGGTTTTT

GATCCGTATA CAATCGTAGA AAAATCCGGG AAAAAGTTTG CCATTGTAGG TGTGACGACC

CCAGAAACAG CAACGAAAAC ACACCCGAAA AACGTAGAGA AGGTGACATT TAAAGACCCG

ATTCCAGAAG TAGAAGCAGT GATTAAGGAA ATTAAAGAGA AGTACGCGGA TATNCAAGCT

TTCGTGGTTA CTGGGCATTT AGGCGTAGAT GAAACGACCC CGCATATCTG GCGTGGTGAT

ACGCTAGCAG AAACCCTTAG TCAAACATAT CCTGAGTTAG ATATCACTGT GATTGATGGA

CATTCGCATA CAGCCGTCGA AAGTGGCAAA CGTTATGGCA AAGTCATCTA TGCTCAAACA

GGTAATTATT TAAATAATGT TGGGATCGTC ACAGCACCAG AGAGTGAACC AACTAAGAAA

ACAACAAAAT TGATTTCAGC AGCAGAGCTG CTAGAATTGC CAGAAAACCC GGCAGTTAAA

GCCATCGTTG ATGAAGCACG TACGAATTTT AACGCTGAAA ATGAAAAAGT AATTGTCGAT

TATATTCCAT TCACATTGGA TGGACAACGA GAAAATGTGC GCACACGAGA GACCAACTTA

GGGAATTTGA TTGGTGATGC GATTATGTCA TATGGCCAAG ACGCGTTTAG CCAACCTGCT

GATTTTGCAG TAACTAATGG TGGCGGCATT CGCGCTGATA TTAAACAAGG GCCAATTAAA

GTTGGGGATG TCATTGCTGT GTTACCTTTT GGCAATAGCA TTGCGCAAAT TCAAGTAACC

GGCGCCCAAG TTAAAGAAAT GTTTGAAATG TCTGTTCGTT CGATTCCACA AAAAGATGAG

AATGGCACAA TTTTACTAGA TGATGCTGGC CAACCAAAAC TTGGCGCAAA TCGTGGTTTC

CTACATGTTT CAAGCTCCAT TCGTATCCAC TATGATTCCA CAAAACCAGG TACTCGCTTG

GCTAGTGACG AAGGCAATGA AACAGGACAA ACGATTGTCG GTAGTCGCGT ATTAGGAATA

GAAATTAAAA ATCGGCAAAC ACAAAAGTTT GAACCATTGG ATGAGAAGAA ACAATACCGG

ATGGCTACCA ATGATTTCTT AGCTGCTGGT GGTGATGGTT ACGATATGCT AGGTGGTGAA

CGAGAAGAAG GGATTTCACT AGATTCTGTC TTAATTGAAT ACTTGAAAAG TGCAACCAGC

TTGCGGTTGT ATCGTGCAGC AACGACGATT GATTTAGCAC AATATAAAGA ACCATTCCCA

GGCGAACGAA TTGTTTCTAT TTCGGAAGAA GCTTACAAAG AGTTAATCGG TGGAGGAGAG

ACGCCAAAAC CAGATCCAAA ACCAGACCCG AAACCAACAC CAGAAACACC AGTAGCAACC

AATAAACAAA ACCAAGCGGG AGCAAGACAG AGCAATCCAT CCGTAACAGA GAAGAAAAAG

TATGGCGGCT TTTTACCTAA AACGGGTACA GAAACAGAAA CGCTTGCATT ATATGGTTTA

CTGTTCGTTG GACTTTCTTC TTCTGGCTGG TATATTTATA AACGACGTAA CAAAGCTAGT

TAG

EF121-2 (SEQ ID NO:450)

VKKL SFKKVKWGMH FLMAVALIAP SVTSTAYAVE TTSQQSSEAV TSTTDSSRKQ

EPVITQETTD IKQEAPNQAT SDSVKQSQET TAPTETTNLE TSIAEKEETS TPQKITILGT

SDVHGQLWNW SYEDDKELPV GLSQVSTVVN QVRAQNPAGT VLIDNGDNIQ GTILTDDLYN

KAPLVNEKTH PMITAMNVMK YDAMVLGNHE FNFGLPLIKK IQQEATFPIL SANTYNKEDG

LRFVEGTTTK ELDFNQDGQP DLKVGIIGLT IPHIPLWDGP RVTSLNFLPL KEEAEKAVTE

LKANDQADII VASIHAGQQN SDPAASADQV IENVAGIDAY ILGHDHLSFT KQGAAPNGKT

VPVGGPKDTG TEVVKIDLSV AKNADKWEVQ EGTATIVPTT NVPADEAVKA ATKEYHEKTR

AFIQEEIGTA TADFLPKQEI KGIPEAQLQP TANISLINNV QKEVTGAQLS AAALFKYDSK

LPAGKISYAT IFDIYKYPNT LVSVPINGEN LLKYLEKQGA YYNQTQPDDL TISFNPNIRV

YNYDMISGVD YKIDISKPVG ERIVDAKIDG QPLDPAKEYT IAMNNYRYGG LASQGIQVGE

PIKNSDPETL RGMIVDYIKK KGTLDPEQEI ERNWSIIGTN FDEKWRAKAT ELVNDGTLQT

PTSPDGRTPN AAAITKQDVR NAGFDLDNAY TIMHTNDVHG RLEAGKGELG MARLKTFKDQ

ENPTLMVDAG DVFQGLPISN FSKGADMAKA MNEVGYDANA VGNHEFDFGL EIALGYKDQL

NFPILSSNTY YKDGSGRVFD PYTIVEKSGK KFAIVGVTTP ETATKTHPKN VEKVTFKDPI

PEVEAVIKEI KEKYADXQAF VVTGHLGVDE TTPHIWRGDT LAETLSQTYP ELDITVIDGH

SHTAVESGKR YGKVIYAQTG NYLNNVGIVT APESEPTKKT TKLISAAELL ELPENPAVKA

IVDEARTNFN AENEKVIVDY IPFTLDCQRE NVRTRETNLG NLIGDAIMSY GQDAFSQPAD

FAVTNGGGIR ADIKQGPIKV GDVIAVLPFG NSIAQTQVTG AQVKEMFEMS VRSIPQKDEN

GTILLDDAGQ PKLGANGGFL HVSSSIRIHY DSTKPGTRLA SDEGNETGQT IVGSRVLGIE

TKNRQTQKFE PLDEKKQYRM ATNDFLAACG DGYDMLGGER EEGISLDSVL IEYLKSATSL

RLYRAATTTD LAQYKEPFPG ERIVSISEEA YKELIGGGET PKPDPKPDPK PTPETPVATN

KQNQAGARQS~NPSVTEKKKY GGFLPKTGTE TETLALYGLLJ FVGLSSSGWY IYKRRNKAS

EF121-3 (SEQ ID NO:451)

ACAAAG TTCAGAAGCA GTAACAAGTA CCACCGATTC AAGTAGAAAA

CAAGAACCAC TCATTACACA CGAAACAACA GACATCAAAC AACAAGCACC AAATCACGCT

ACGAGTGACA GTGTCAAGCA GTCACAACAA ACCACAGCAC CAACAGAGAC GACCAATTTA

GAAACGTCAA TCGCTGAAAA AGAAGAAACG AGCACGCCGC AAAAAATAAC AATTTTAGGT

ACGTCAGATG TTCATGGTCA ATTATGGAAT TGGTCTTATG AAGATCATAA AGAACTACCA

GTTGGTTTGT CCCAAGTAAG TACAGTCGTT AACCAAGTCC GGGCACAAAA CCCAGCAGGC

ACCGTTTTAA TTCATAATGG CGACAATATT CAAGGCACTA TTTTAACAGA TGACTTGTAT

AATAAAGCGC CTTTAGTGAA TGAAAAGACC CATCCAATGA TCACCCCCAT GAATGTGATG

AAGTATGATG CAATGGTTTT CGGAAATCAT GAGTTTAATT TTCGTTTACC GTTAATCAAA

AAAATTCAAC AAGAAGCCAC TTTTCCAATC TTGTCTGCGA ATACCTACAA TAAGGAAGAT

GGTCTTCGTT TTGTTGAAGG GACTACCACG AAGGAACTTG ATTTTAATCA AGATGGGCAC

CCAGATTTAA AAGTTGGGAT TATCGGCTTA ACAATTCCGC ACATTCCTTT GTGGGATGGC

CCTCGTGTTA CTTCGCTTAA TTTTTTACCT TTGAAACAAG AAGCAGAAAA AGCAGTTACT

GAGTTGAAAC CTAACGATCA CCCTGACATT ATTGTTGCCT CGATTCATGC GGCACAACAA

AATAGTGATC CGGCTGCCAG TCCCGACCAA CTAATTGAAA ATGTCGCGGG GATTGATGCC

TATATTCTGG GTCATGACCA CCTTTCTTTT ACCAACCAAG GAGCAGCGCC GAATGGAAAA

ACTGTACCCG TAGGGGGACC GAAAGATACG GGGACAGAAG TTGTCAAAAT TGATCTTTCA

GTTGCTAAAA ATGCCGATAA GTGGGAAGTG CAAGAAGGTA CAGCAACGAT TGTACCAACA

ACCAATGTTC CAGCAGATGA AGCAGTTAAG GCAGCGACAA AAGAATACCA TGAAAAAACG

CGAGCGTTTA TTCAGCAGCA GATCGGCACA GCAACAGCTG ATTTTTTACC AAAACAAGAA

ATTAAAGGAA TTCCCGAAGC ACAATTACAA CCAACAGCGA TGATTTCTTT AATTAATAAC

GTTCAAAAAG AAGTAACCGG CGCACAATTA AGTGCGGCAG CGCTOTTTAA ATACGACAGT

AAATTACCTG CGCCGAAGAT TTCCTATGCC ACGATTTTTG ATATCTACAA ATACCCGAAT

ACCTTAGTGA GTGTTCCCAT TAACGGTGAA AACTTACTGA ACTATTTACA AAAACAACCG

GCGTACTATA ACCAAACACA GCCAGATGAT TTGACCATTA GTTTTAATCC AAACATTCGT

CTATATAACT ATGACATGAT TTCTGGAGTC GACTACAACA TTGACATTTC AAAACCAGTG

GGTGAACGAA TTGTAGATGC CAAAATTGAC GGCCAACCGC TGGATCCTGC CAAAGAATAT

ACGATTGCTA TGAATAATTA TCGTTACGGC GGTTTAGCTA GCCAAGGCAT TCAAGTAGGG

GAACCTATTA AAAATTCTGA TCCAGAAACC TTACGAGCAA TGATTGTTGA TTATATTAAG

AAAAAAGGAA CTCTTGATCC AGAACAAGAA ATCGAACGAA ATTGGTCAAT TATTGGGACA

AATTTTGATG AAAAATGGCG TGCCAAAGCA ATCCAATTAG TGAATGACGG CACTCTTCAA

ATTCCGACTT CTCCTGATGC ACGTACACCA AACCCCG

EF121-4 (SEQ ID NO:452)

QSSEAV TSTTDSSRKQ

EPVITQETTD IKQEAPNQAT SDSVKQSQET TAPTETTNLE TSIAEKEETS TPQKITILGT

SDVHGQLWNW SYEDDKELPV GLSQVSTVVN QVRAQNPAGT VLIDNGDNIQ GTILTDDLYN

KAPLVNEKTH PMITAMNVMK YDAMVLCNHE FNFGLPLIKK IQQEATFPIL SANTYNKEDO

LRFVEGTTTK ELDFNQDGQP DLKVGIIGLT IPHIPLWDGP RVTSLNFLPL KEEAEKAVTE

LKANDQADII VASIHAGQQN SDPAASADQV TENVAGIDAY ILGHDHLSFT KQGAAPNGKT

VPVGGPKDTG TEVVKIDLSV AKNADKWEVQ EGTATIVPTT NVPADEAVKA ATKEYHEKTR

AFIQEEIGTA TADFLPKQET KGIPEAQLQP TAMISLINNV QKEVTGAQLS AAALFKYDSK

LPAGKISYAT IFDIYKYPNT LVSVPTNGEN LLKYLEKQGA YYNQTQPDDL TISFNPNIRV

YNYDMISGVD YKIDISKPVG ERIVDAKIDG QPLDPAKEYT IAMNNYRYGG LASQGIQVGE

PIKNSDPETL RGMTVDYIKK KGTLDPEQEI ERNWSITGTN FDEKWRAKAI ELVNDGTLQI

PTSPDGRTPN A

EF122-1 (SEQ ID NO:453)

TGAAACACAA GGAGGAAATT TGTGAAAAAG TTGAGCTTTA AAAAAGTGAA GTGGGGCATG

CATTTTTTAA TGGCTGTTGC GTTGATAGCG CCAAGTGTTA CTAGTACGGC ATATGCAGTA

GAAACAACGA GTCAACAAAG TTCAGAAGCA GTAACAAGTA CCACCGATTC AAGTAGAAAA

CAAGAACCAG TCATTACACA GGAAACAACA GACATCAAAC AAGAAGCACC AAATCAGGCT

ACGAGTGACA GTGTCAAGCA GTCACAAGAA ACCACAGCAC CAACAGAGAC GACCAATTTA

GAAACGTCAA TCGCTGAAAA AGAAGAAACG AGCACGCCGC AAAAAATAAC AATTTTAGGT

ACGTCAGATG TTCATGGTCA ATTATGGAAT TGGTCTTATG AAGATGATAA AGAACTACCA

GTTGGTTTCT CCCAAGTAAG TACAGTCGTT AACCAAGTCC GGGCACAAAA CCCAGCAGGC

ACCGTTTTAA TTGATAATGG CGACAATATT CAAGGCACTA TTTTAACAGA TGACTTGTAT

AATAAAGCGC CTTTAGTGAA TGAAAAGACC CATCCAATGA TCACCGCCAT GAATGTGATG

AAGTATGATG CAATGGTTTT GGGAAATCAT GAGTTTAATT TTGGTTTACC GTTAATCAAA

AAAATTCAAC AAGAAGCCAC TTTTCCAATC TTGTCTGCGA ATACCTACAA TAAGGAAGAT

GGTCTTCGTT TTGTTGAAGG GACTACCACG AAGGAACTTG ATTTTAATCA AGATGGGCAG

CCAGATTTAA AAGTTGGGAT TATCGGCTTA ACAATTCCGC ACATTCCTTT GTGGGATGGC

CCTCGTGTTA CTTCGCTTAA TTTTTTACCT TTGAAAGAAG AAGCAGAAAA AGCAGTTACT

GAGTTGAAAG CTAACGATCA GGCTGACATT ATTGTTGCCT CGATTCATGC CGGACAACAA

AATAGTGATC CGGCTGCCAG TGCCGACCAA GTAATTGAAA ATGTCGCGGG GATTGATGCG

TATATTCTGG GTCATGACCA CCTTTCTTTT ACCAAGCAAG GAGCAGCGCC GAATGGAAAA

ACTGTACCGG TAGGGGGACC GAAAGATACG GGGACAGAAG TTGTCAAAAT TGATCTTTCA

GTTGCTAAAA ATGCCGATAA GTGGGAAGTG CAAGAAGGTA CAGCAACGAT TGTACCAACA

ACGAATGTTC CAGCAGATGA AGCAGTTAAG GCAGCGACAA AAGAATACCA TGAAAAAACG

CGAGCGTTTA TTCAGGAGGA GATCGGCACA GCAACAGCTG ATTTTTTACC AAAACAAGAA

ATTAAAGGAA TTCCCGAAGC ACAATTACAA CCAACAGCGA TGATTTCTTT AATTAATAAC

GTTCAAAAAG AAGTAACGGG CGCACAATTA AGTGCGGCAG CGCTGTTTAA ATACGACAGT

AAATTACCTG CGGGGAAGAT TTCCTATGCC ACGATTTTTG ATATCTACAA ATACCCGAAT

ACCTTAGTGA GTGTTCCCAT TAACGGTGAA AACTTACTGA AGTATTTAGA AAAACAAGGG

GCGTACTATA ACCAAACACA GOCAGAIGAT TTGACCATTA GTTTTAATCC AAACATTCGT

GTATATAACT ATGACATGAT TTCTGGAGTG GACTACAAGA TTGACATTTC AAAACCAGTG

GGTGAACGAA TTGTAGATGC GAAAATTGAC GGCCAACCGC TGGATCCTGC CAAAGAATAT

ACGATTGCTA TGAATAATTA TCGTTACGGC GGTTTAGCTA GCCAAGGGAT TCAAGTAGGG

GAACCTATTA AAAATTCTGA TCCAGAAACC TTACGAGGAA TGATTGTTGA TTATATTAAG

AAAAAAGGAA CTCTTGATCC AGAACAAGAA ATCGAACGAA ATTGGTCAAT TATTGGGACA

AATTTTGATG AAAAATGGCG TGCCAAAGCA ATCGAATTAG TGAATGACGG CACTCTTCAA

ATTCCGACTT CTCCTGATGG ACOTACACCA AACGCCGCCG CTATTACGAA ACAAGATGTC

CGTAATGCGG GCTTTGATTT AGATAATGCA TATACCATTA TGCACACAAA TGACGTTCAT

GGCCGACTAG AAGCAGGGAA AGGCGAATTA GGTATGGCGC GTCTAAAAAC CTTTAAAGAC

CAAGAAAACC CAACCTTGAT GGTGGATGCA GGGGATGTTT TCCAAGGATT ACCAATCTCC

AATTTCTCCA AAGGCGCGGA TATGGCCAAA GCAATGAATG AAGTTGGTTA TGATGCCATG

GCGGTGGGAA ATCACGAGTT TGATTTTGGT TTAGAGATTG CACTAGGTTA TAAAGACCAA

CTGAATTTTC CGATTTTATC TAGTAATACG TATTACAAAG ATGGCAGTGG ACGGGTTTTT

GATCCGTATA CAATCGTAGA AAAATCCGGG AAAAAGTTTG CCATTGTAGG TGTGACGACC

CCAGAAACAG CAACGAAAAC ACACCCGAAA AACGTAGAGA AGGTGACATT TAAAGACCCG

ATTCCAGAAG TAGAAGCACT GATTAACCAA ATTAAAGAGA ACTACGCGGA TATNCAAGGT

TTCGTGGTTA CTGGGCATTT AGGCGTAGAT GAAACGACGC CGCATATCTG GCGTGGTGAT

ACGCTACCAG AAACCCTTAG TCAAACATAT CCTCACTTAG ATATCACTGT GATTOATOGA

CATTOCCATA CAGCCGTCGA AAGTGGCAAA CGTTATGGCA AAGTGATCTA TCCTCAAACA

GGTAATTATT TAAATAATGT TGGCATCGTC ACAGCACCAG AGAGTGAACC AACTAAGAAA

ACAACAAAAT TGATTTCAGC AGCAGAGCTG CTACAATTGC CAGAAAACCC GGCAGTTAAA

GCCATCGTTC ATGAAGCACG TACGAATTTT AACGCTGAAA ATGAAAAAGT AATTGTCGAT

TATATTCCAT TCACATTGGA TGGACAACGA GAAAATGTGC GCACACGAGA GACCAACTTA

GGGAATTTGA TTGGTGATGC GATTATGTCA TATGGCCAAG ACGCGTTTAG CCAACCTGCT

GATTTTGCAG TAACTAATGG TGCCCGCATT CGCGCTGATA TTAAACAAGG GCCAATTAAA

GTTGGGGATG TCATTGCTGT GTTACCTTTT GGCAATAGCA TTGCGCAAAT TCAAGTAACC

GGCGCCCAAC TTAAAGAAAT GTTTGAAATG TCTGTTCGTT CGATTCCACA AAAAGATGAG

AATGGCACAA TTTTACTAGA TGATGCTGGC CAACCAAAAC TTGGCGCAAA TGGTGGTTTC

CTACATCTTT CAAGCTCCAT TCGTATCCAC TATGATTCCA CAAAACCAGG TACTCGCTTG

GCTAGTGACG AAGGCAATGA AACAGGACAA ACGATTGTCG GTAGTCGCGT ATTAGGAATA

GAAATTAAAA ATCGGCAAAC ACAAAAGTTT GAACCATTGG ATGAGAAGAA ACAATACCGC

ATGGCTACCA ATGATTTCTT AGCTGCTGGT GGTGATGGTT ACGATATGCT AGGTGGTGAA

CGAGAACAAG GGATTTCACT ACATTCTGTC TTAATTGAAT ACTTCAAAAG TCCAACCAGC

TTGCGGTTGT ATCGTGCAGC AACGACGATT GATTTAGCAC AATATAAAGA ACCATTCCCA

GGCGAACGAA TTGTTTCTAT TTCGGAAGAA GCTTACAAAG AGTTAATCGG TGGAGGAGAG

ACGCCAAAAC CAGATCCAAA ACCAGACCCC AAACCAACAC CAGAAACACC AGTAGCAACC

AATAAACAAA ACCAAGCGGG AGCAAGACAG AGCAATCCAT CCGTAACAGA GAAGAAAAAG

TATGGCGGCT TTTTACCTAA AACGGGTACA GAAACAGAAA CGCTTGCATT ATATGGTTTA

CTGTTCGTTG GACTTTCTTC TTCTGGCTGG TATATTTATA AACGACGTAA CAAAGCTAGT

TAG

EF122-2 (SEQ ID NO:454)

VKKL SFKKVKWGMH FLMAVALIAP SXTTSTAYAVE TTSQQSSEAV TSTTDSSRKQ

EPVITQETTD IKQEAPNQAT SDSVKQSQET TAPTETTNLE TSIAEKEETS TPQKTTTLGT

SDVHGQLWNW SYEDDKELPV GLSQVSTVVN QVBAQNPAGT VLIDNGDNIQ GTILTDDLYN

KAPLVNEKTH PMITANNVMK YDAMVLGNHE FNFGLPLIKK IQQEATFPTL SANTYNKEDG

LRFVEGTTTK ELDFNQDGQP DLKVGIIGLT IPHIPLWDGP RVTSLNFLPL KEEAEKAVTE

LKANDQADII VASIHAGQQN SDPAASADQV TENVAGIDAY ILGHDHLSFT KQGAAPNGKT

VPVGGPKDTG TEVVKTDLSV AKNADKWEVQ EGTATIVPTT NVPADEAVKA ATKEYHEKTR

AFIQESIOTA TADFLPKQEI KGIPEAQLQP TAMISLINNV QKEVTGAQLS AAALFKYDSK

LPAGKISYAT IFDIYKYPNT LVSVPINGEN LLKYLEKQGA YYNQTQPDDL TTSFNPNIRV

YNYDMISGVD YKIDISKPVG ERIVDAKIDG QPLDPAKEYT IAMNNYRYGG LASQGIQVGE

PIKNSDPETL RGMIVDYIKK KGTLDPEQET EENWSIIGTN FDEKWRAKAI ELVNDGTLQT

PTSPDGRTPN AAAITKQDVR NAGEDLONAY TIMHTNDVHG RLEAGKGELG MARLKTFKDQ

ENPTLMVDAG DVFQGLPISN FSKGADMAKA MNEVGYDAMA VGNHEFDFGL EIALGYKDQL

NFPILSSNTY YKDGSGRVFD PYTIVEKSGK KFATVGVTTP ETATKTHPKN VEKVTFKDPI

PEVEAVIKET KEKYADXQAF VVTGHLGVDE TTPHIWRGDT LAETLSQTYP ELDITVIDGH

SHTAVESGKR YGKVIYAQTG NYLNNVGIVT APESEPTKKT TKLISAAELL ELPENPAVKA

IVDEARTNFN AENEKVIVDY IPFTLDGQRE NVRTRETNLG NLIGDAIMSY GQDAFSQPAD

FAVTNGGGIR ADIKQGPTKV GDVIAVLPFG NSIAQTQVTG AQVKEMFEMS VRSIPQKDEN

GTILLDDAGQ PKLGANGGFL EVESSIRIHY DSTKPGTRLA SDEGNETCQT IVGSRVLGIE

IKNRQTQKFE PLDEKKQYRM ATNDFLAAGG DGYDMLGGER EEGTSLDSVL IEYLKSATSL

RLYPAATTTD LAQYKEPEPG ERIVSISEEA YKELIGGGET PKPDPKPDPK PTPETPVATN

KQNQAGARQS NPSVTEKKKY GGFLPKTGTE TETLALYGLL FVGLSSSGWY IYKRPNKAS

EF122-3 (SEQ ID NO:455)

TG AAAAATGGCG TGCCAAAGCA ATCGAATTAG TGAATGACGG CACTCTTCAA

ATTCCGACTT CTCCTGATGG ACGTACACCA AACGCCGCCG CTATTACGAA ACAAGATGTC

CGTAATGCGG GCTTTGATTT AGATAATGCA TATACCATTA TGCACACAAA TGACGTTCAT

GGCCGACTAG AAGCAGGGAA AGGCGAATTA GGTATGGCGC GTCTAAAAAC CTTTAAAGAC

CAAGAAAACC CAACCTTGAT GGTGGATCCA GGGGATGTTT TCCAAGGATT ACCAATCTCC

AATTTCTCCA AAGGCGCGGA TATGGCCAAA GCAATGAATG AAGTTGGTTA TGATGCCATG

GCGGTGGGAA ATCACGAGTT TGATTTTGGT TTAGAGATTG CACTACGTTA TAAAGACCAA

CTGAATTTTC CGATTTTATC TAGTAATACG TATTACAAAG ATGGCAGTGG ACGGGTTTTT

GATCCGTATA CAATCGTAGA AAAATCCGGG AAAAAGTTTG CCATTGTAGG TGTGACGACC

CCAGAAACAG CAACGAAAAC ACACCCGAAA AACGTAGAGA AGGTGACATT TAAAGACCCC

ATTCCAGAAG TAGAAGCAGT GATTAAGGAA ATTAAAGAGA AGTACGCGGA TATNCAAGCT

TTCGTGGTTA CTGGGCATTT AGGCGTAGAT GAAACGACGC CGCATATCTG GCGTGGTGAT

ACGCTAGCAG AAACCCTTAG TCAAACATAT CCTGAGTTAG ATATCACTGT GATTGATGGA

CATTCGCATA CAGCCGTCGA AAGTGGCAAA CGTTATGGCA AAGTGATCTA TGCTCAAACA

GGTAATTATT TAAATAATGT TGGGATCGTC ACAGCACCAG AGAGTGAACC AACTAAGAAA

ACAACAAAAT TGATTTCAGC AGCAGAGCTG CTAGAATTGC CAGAAAACCC GGCAGTTAAA

GCCATCGTTG ATGAAGCACG TACGAATTTT AACGCTGAAA ATGAAAAAGT AATTGTCGAT

TATATTCCAT TCACATTGGA TGGACAACGA GAAAATGTGC GCACACGAGA GACCAACTTA

GGGAATTTGA TTGGTGATGC GATTATGTCA TATGGCCAAG ACGCGTTTAG CCAACCTGCT

GATTTTGCAG TAACTAATGG TGGCCGCATT CGCGCTGATA TTAAACAAGG GCCAATTAAA

GTTGGGGATG TCATTCCTGT GTTACCTTTT GGCAATAGCA TTGCGCAAAT TCAAGTAACC

GGCGCCCAAG TTAAAGAAAT GTTTGAAATG TCTGTTCGTT CGATTCCACA AAAAGATGAG

AATGGCACAA TTTTACTAGA TGATGCTGGC CAACCAAAAC TTGGCGCAAA TGGTGGTTTC

CTACATGTTT CAAGCTCCAT TCGTATCCAC TATCATTCCA CAAAACCAGG TACTCGCTTG

GCTAGTGACG AAGGCAATGA AACAGGACAA ACCATTGTCC GTAGTCGCGT ATTAGGAATA

GAAATTAAAA ATCGGCAAAC ACAAAAGTTT GAACCATTGG ATGAGAAGAA ACAATACCGG

ATGGCTACCA ATGATTTCTT AGCTGCTGGT GGTGATGGTT ACGATATGCT AGGTCGTGAA

CGAGAAGAAG GGATTTCACT AGATTCTGTC TTAATTGAAT ACTTGAAAAG TGCAACCAGC

TTGCGGTTGT ATCGTGCAGC AACGACGATT GATTTAGCAC AATATAAAGA ACCATTCCCA

GGCGAACGAA TTGTTTCTAT TTCGGAAGAA GCTTACAAAG AGTTAATCGG TGGAGGAGAG

ACGCCAAAAC CAGATCCAAA ACCAGACCCG AAACCAACAC CAGAAACACC AGTAGCAACC

AATAAACAAA ACCAAGCGGG AGCAAGACAG AGCAATCCAT CCGTAACAGA GAAGAAAAAG

TATGGCGGCT TT

EF122-4 (SEQ ID NO:456)

EKWRAKAI ELVNDGTLQI

PTSPDCRTPN AAAITKQDVR NAGFDLDNAY TIMHTNDVHG RLEAGKGELG MARLKTFKDQ

ENPTLMVDAG DVFQGLPISN FSKGADMAKA MNEVGYDAMA VGNHEFDFGL EIALGYKDQL

NFPILSSNTY YKDGSGRVFD PYTIVEKSGK KFAIVGVTTP ETATKTHPKN VEKVTFKDPI

PEVEAVIKEI KEKYADXQAF VVTGHLGVDE TTPHIWRGDT LAETLSQTYP ELDITVIDGH

SHTAVESGKR YGKVTYAQTG NYLNNVGIVT APESEPTKKT TKLISAAELL ELPENPAVKA

IVDEARTNFN AENEKVIVDY IPFTLDGQRE NVRTRETNLG NLIGDAIMSY GQDAFSQPAD

FAVTNGGGIR ADIKQGPIKV GDVIAVLPFG NSTAQIQVTG AQVKEMFEMS VRSIPQKDEN

GTILLDDAGQ PKLGANGGFL HVSSSIRIHY DSTKPGTRLA SDEGNETGQT IVGSRVLGIE

LKNRQTQKFE PLDEKKQYRM ATNDFLAAGG DGYDMLGGER EEGISLDSVL IEYLKSATSL

RLYRAATTID LAQYKEPFPG ERIVSISEEA YKELIGGGET PKPDPKPDPK PTPETPVATN

KQNQAGARQS NPSVTEKKKY GGF

EF123-1 (SEQ ID NO:457)

TAAAATAAAA AATTGGTACG AAGTGAACGT TCTCTTCTAT GTGTCGTTAG TAGAGGAAGG

ATGAAAGAAA TGAGAAAGAA TGGTCCAATG GTAAACCGTT GGCTCTACGG GTTGATGTGT

TTGTTACTTG TTCTAAATTA TGGCACACCA CTCATGGCTT TGGCGGAAGA GGTTAACAGC

GATGGCCAGT TAACGTTAGG AGAAGTGAAG CAAACCAGCC AGCAAGAAAT GACCTTAGCG

CTTCAAGGAA AAGCACAACC AGTAACACAA GAGGTTGTAG TGCATTATAG TGCCAATGTG

TCAATCAAAG CTGCACATTG GGCAGCGCCC AATAATACGC GCAAGATTCA AGTGGATGAC

CAGAAGAAAC AGATTCAAAT TGAATTGAAT CAGCAAGCGT TAGCAGATAC CTTAGTCTTA

ACGTTGAACC CTACAGCTAC AGAAGATGTG ACGTTTTCTT ATCGACAACA GCAACGAGCG

TTGACGTTAA AGACTGGTAC TGATCCGACA GAATCAACGG CAATCACGAG TTCGCCAGCC

GCATCAGCGA ATGAAGGTTC AACAGAAGAA GCATCTACAA ACTCCTCTGT TCCTCGTTCG

TCCGAAGAAA CTGTCGCCAG CACGACAAAA GCGATAGAAA GTAAAACAAC TGAATCGACG

ACTGTCAAAC CGCGCGTAGC AGGACCAACA GATATCAGTG ATTATTTTAC AGGTGATGAA

ACAACGATTA TCGATAATTT TGAAGATCCG ATTTATTTAA ATCCTGATGG AACACCAGCA

ACACCGCCGT ATAAAGAAGA TGTGACCATT CATTGGAACT TTAACTGGTC GATTCCAGAA

GATGTGCGAG AACAAATGAA AGCAGGCGAT TACTTCGAGT TTCAATTACC TGGCAATTTG

AAACCTAATA AACCAGGTTC AGGTGATTTA CTTGATGCAG AAGGCAATGT CTATGGAACC

TACACAATTA GTGAAGATGG TACGGTTCGT TTTACCTTTA ATGAGCGAAT CACGTCTGAA

AGTGACATTC ACGGGGACTT TTCTTTAGAT ACTCATTTGA ATGATTCAGA TGGGCGGGGC

CCAGGAGATT GGGTGATTGA TATTCCTACA CAAGAAGATT TGCCGCCTGT AGTGATTCCA

ATTGTCCCAG ATACCGAACA ACAAATTGAT AAACAAGGCC ATTTTGATCG AACGCCCAAT

CCTAGTGCGA TTACTTGGAC GGTAGATATC AATCAAGCGA TGAAAGATCA AACAAATCCA

ACTGTGACGG AAACATGGCC AACAGGGAAT ACCTTTAAGT CCGTGAAAGT CTATGAGTTA

GTGATCAATC TTGATGGAAC AATTAAAGAA GTGGGTCGCG AACTTAGTCC AGATGAATAT

ACCGTTGATA AAAATGGCAA TGTGACGATT AAAGGTGACA CCAACAAAGC GTATCGTCTT

GAGTACCAAA CGACGATTGA CGAGGCGGTT ATTCCAGATG GCGGCGGCGA TCTGCCTTTT

AAAAATCACG CGACGTTAAC AAGTGATAAT AATCCAAATG GGTTAGATGC TGAAGCAACT

GTTACCGCCA CATATGGCAA AATGTTAGAC AACCGCAATA TAGATTACGA CGAAGCCAAT

CAAGAATTCA CTTGGGAAAT TAACTACAAC TATGGTGAAC AAACCATTCC AAAAGACCAA

GCAGTCATTA CAGACACAAT GGGGGATAAT TTAACGTTTG AACCAGATTC TTTACATTTA

TATTCAGTGA CATTTGATGA CAAAGGAAAT GAAGTCGTTG GAGCAGAACT TGTGGAAGGA

AAAGATTACA AAGTGGTAAT CAACGGAGAC GGTTCCTTTG CAATTGACTT TTTACATGAT

GTGACTGGCG CAGTCAAGAT TGATTATAAA ACCAAAGTTG ATGGAATTGT CGAAGGCGAT

GTTGCCGTGA ATAATCGTGT GGATGTTGGC ACTGGTCAGC ATTCAGAAGA TGATGGCACA

GCCAGTCAAC AAAATATTAT TAAAAACACT GGTGCAGTTG ATTATCAAAA TTCAACGATT

GGTTGGACGT TAGCTGTGAA TCAAAATAAT TATTTGATGG AAAATGCCGT GATTACGGAT

ACGTACGAAC CAGTTCCTGG CTTAACTATG GTACCCAATT CGTTGGTTGT CAAAGATACA

ACCACTGGTG CTCAGTTGAC GTTAGGCAAG GATTTCATGG TAGAAATAAC TCGTAATGCA

GATGGTGAAA CAGGCTTTAA GGTAAGTTTT ATAGGGGCGT ATGCCAAAAC AAGTGATCCC

TTCCACATAA CTTATACTAC CTTTTTCGAT GTTACCGAGT TAGACGCTAA CAATCCTGCG

TTGGACCATT ATCGAAATAC CGCTGCCATT GATTGGACGG ATGAAGCAGG AAACAATCAT

CATTCAGAAG ATAGTAAACC GTTTAAACCT TTACCTGCTT TTGATTTAAA TGCGCAAAAA

AGCGGTGTTT ACAATGCCGT CACCAAAGAA ATCACTTGGA CGATTGCGGT TAATTTAAGT

AATAATCGTT TAGTCGACGC CTTTTTGACG GATCCAATTT TAACCAATCA AACCTATTTG

GCTGGGACCT TGAAAGTCTA TGAAGGCAAT ACAAAGCCAG ATGGTTCGGT TGAAAAAGTG

AAACCAACGC AACCGTTGAC GGATATCACA ATGGAAGAAC CAAGCGAGAA AAACCAAAAT

ACTTGGCGTG TTGATTTTCC TAATGATACT CGTACGTATG TGATTGAATT TAAGACGTCT

GTTGATGAAA AAGTTATCGA AGGTTCGGCT AGTTATGACA ATACCGCATC TTATACAAAC

CAAGGTTCTT CACGTCATGT GACAGGAAAA GTTTCTATTC AACATGGTGG CGAATCAGTG

AAAAAAGCTG GCGAATACCA CAAAGATGAT CCAGATCATG TGTACTGGCA TGTAATGATC

AATGGCGCCC AATCGGTTTT AGACGATGTG GTTATTACTG ATACACCCTC ACCAAACCAA

GTGCTAGATC CCGAGTCATT GGTGATTTAC GGTACCAACG TAACAGAAGA CGGAACTATT

ACGCCAGATA AATCTGTTAT TTTAGAAGAA GGAAAAGATT ACACACTGGA AGTTACCACC

GATAATGAAA CAGGACAACA AAAAATTGTC GTTAAAATGG CCCATATTGA AGCACCTTAT

TATATGGAAT ATCGTAGTTT AGTGACTTCT TCAGCGGCGG GGAGTACAGA CACGGTATCC

AACCAAGTGT CAATTACTGG AAATGGTTCA GAAGTCGTTC ATGGGGATGA CAATGGCGAT

GTGGTCGTTG ACATTGATCA CAGTGGCGGG CATGCCACAG GGACTAAAGG CAAAATTCAG

CTGAAGAAAA CAGCCATGGA TGAGACGACT ATTTTAGCAG GCGCCCATTT CCAAATTTGG

GACCAAGCTA AAACACAAGT CCTACGTGAA GGTACAGTAG ATGCCACCGG GGTTATCACA

TTTGGTGGGT TGCCACAAGG GCAATACATT TTGGTGGAGA CAAAAGCACC AGAACGCTAT

ACAGTTTCGG ACGAATTAGC TAAAGGCCGA GTCATTACTA TTGATGAAGA AACTTCAGCC

GAAGGAGCAC AACCAACCAT TATTAAAAAC GATGTCAATA AAGTATTTTT AGAAAAAATG

GATGAGAAGG GTAAAAAGTT AGTCAATGCT CGCTTTAAAT TAGAGCATGC CGTAACCACG

CCGTTTACTC ATTGGGAAGA AGTTCCCCTT GCGCCGGATC GAACCAACGC GAATGGCCAG

TTAGAGGTGG ATAGTTTAAA ACCAGGGCTT TATCAGTTCA CAGAAATCGA AGCACCGACA

GGCTATCTTT TAGACACOAC CCCCAAACGA TTCATCGTGA CACAAAATAC GAGCGGACAA

ATTCGTGATG TTCATGTCAA AATGCTTAAT TACCAAGGTT CTGCTGAACT AATTAAAAAA

GACCAAGCAG GCAATCCATT AGCAGGTGCT GAATTTTCAG TCCTTGACAC CACAGGACAA

GCAGTTCGAG AACACTTAGT TTCGGATGCA AACGGAAAAG TCACAGTGAC GGATTTAGCC

CCAGGAAAAT ATCAATTTGT GGAAACCAAA GCGCCAGCAG GGTACCTTTT AAACACTGAA

CCAAGTGCTT TCACGATTGC AGCAAGCGAT CGGGGCAAAC CAGCAACAGT TATAGCAACG

GCTAACTTTG TTAACTATCA AGGCACGGCT AAATTAATCA AAAAAGATGT GAATGGACAC

TTATTAAGTG GTGCGACATT TAAAGTGCTT GATGCGAAGG GAGAAACGAT TCAAACAGGC

TTGACGACAA ATAATCAAGG GGAAATTGTT GCAGAGCACT TAGCCCCAGG AAAATATCGC

TTTGTAGAAA CCAAAGCGCC AACAGGCTAT TTATTAAATA CCACGCCAGT CCCATTTGAA

ATTGCTGAGA AAAATGCTGG TAAACCAGCG GTCGTGGTTG CTAGTGACAA CTTTGTGAGT

TACAAAGGCG CTTTCCAAAT CGTGAAAACG AATAGCGCAG ACCAACCATT AGCAGGTGCT

GTTTTTGAAT TATATGATCA CAATAAACAA TCATTAGGGA TTACAGCAAC GAGTGGCAAA

GATGGCAAAA TTATCTTTAG AGACTTGGCG CCAGGTACCT ATTATTACAA AGAAATCAAA

GCACCAAAAT TACCAGATGG CGCAGATTAT ATTATTTATC CTGAATTAGT AAAAGTAGAA

ATTCGTGGTG ATTTCAAAGG TGATCCGGAG ATTTTCCAAT TAGGGGCCTT CGCCAATTTC

AAAGGACGCG CCGTCTTTAA GAAAATTGAT GCCAATGCGA ACCCACTTCC AGGAACGATT

TTTAAATTGT ATCGAATCGA AAACGGGGAA AAAATCTTTG AAAGAGAACT AACTGCTGAA

AAAGATGGTT CATTGGCTAT GGAGGATTTA GGTGCTGGTA GCTATGAATT AGATGAACTG

GATGCAACGG ATGGCTATAT CGTCAATAAA CAACCCATTT ATTTTGTAGT GAAGAAGAAT

TCAAATGATA AACAACCACT AGATGAGTTA GAGTTTGTAA ATTATCAAGC AGAAGTAATG

GGACGTAAAG TCAACGAGCA AGGTCAAACC TTAGCGGGTG CAGTTTTTGC AATTTACAAT

GCCGATGAGC AGAATCAGCC CCAAGGTTCA CCGATAACAT TCTTGAATCG TGCAGGAGAA

AAAGTTTCTG AAATAACAAC GGATAAGACT GGCGAAATTT ACGCTAAAGG GCTAAATGAA

GGGCATTACG TTTTAGTGGA AACGAAAGCA CCAACAGGCT ATCTGTTAGA CACAACGCTA

CATCCATTTG ATGTAACCGC CCAATTAGGA AAAGAGCAGC CAATTGCTTT AGGCGATCTT

ATCAATTATC AAGGAACTGC TCAATTAACC AAAGAAAACG AAACAGGTGA AGCATTGGCA

GGTGCGGTGT TTAAGGTCAT TGATGAAACA GGGCAAACCG TAGATGGACA AACCAATCTG

ATGTCTGACA AGCAAGGCAA AGTCATTGCG AAAAACTTAG CACCGGGAAC GTATCGTTTT

GTGGAGACAC AAGCGCCAAC TAGCTATCTT CTTAATGAAA CGCCAAGCGC AAGCTTTACG

ATTGCCAAAG ACAACCAAGG CAAACCAGCC ACTGTGGTAC TTAAAGCACC TTTTATTAAT

TACCAAGGTG CTGCCAAGCT GGTGAAAATT GATCAGCAAA AGAATGCCTT AGCAGGTGCT

GAATTTAAAG TGACAGATGC AGAGACAGGG CAAACTGTCG CTCGTTCATT ACGTTCTGAC

AACCAAGGGT TAGTTCAAGT GAACCACTTA CAACCAGGAA AATATACCTT TGTGGAAACA

AAAGCACCGG ATGGTTACCA ACTGTCTAAG CAAGCTGTCG CATTOACTAT TGCGGCAACA

GCGAAAGACA AACCTGAACT CGTGAATGCG GGCACGTTTG TTAACGAGAA ACAACCTGTA

TCCAAAAAAA CAAAACCAAA TCAGCCAACA ACGAAACAAG CAGCTAGAGA GACAGGTTGG

CTTGGTTTAC CGAAAACCAA CACACAAGTC AATTACTTCT TTGTCTTTAT CGGCCTCATG

TTGGTCGGTT TGGCAAGTTG GCTCTTCTAT AAAAAGAGCA AGAAATAA

EF123-2 (SEQ ID NO:458)

MRKNGPMV NRWLYGLMCL LLVLNYGTPL MALAEEVNSD

GQLTLGEVKQ TSQQEMTLAL QGKAQPVTQE VVVHYSANVS IKAAHWAAPN NTRKIQVDDQ

KKQIQIELNQ QALADTLVLT LNPTATEDVT FSYGQQQRAL TLKTGTDPTE STAITSSPAA

SANEGSTEEA STNSSVPRSS EETVASTTKA IESKTTESTT VKPRVAGPTD ISDYFTGDET

TTIDNFEDPT YLNPDGTPAT PPYKEDVTIH WNFNWSIPED VREQNKACDY FEFQLPGNLK

PNKPGSGDLV DAEGNVYGTY TISEDGTVRF TFNERITSES DIHGDFSLDT HLNDSDGRGP

CDWVIDIPTQ EDLPPVVTPI VPDTEQQIDK QGHFDRTPNP SAITWTVDIN QANKDQTNPT

VTETWPTGNT FKSVKVYELV MNLDGTIKEV GRELSPDEYT VDKNCNVTIK GDTNKAYRLE

YQTTIDEAVT PDGGGDVPFK NHATLTSDNN PNCLDAEATV TATYGKMLDK RNIDYDEANQ

EFTWETNYNY GEQTIPKDQA VITDTMGDNL TFEPDSLHLY SVTFDDKGNE VVGAELVEGK

DYKVVINGDG SFAIDFLHDV TGAVKIDYKT KVDGIVEGDV AVNNRVDVCT GQHSEDDGTA

SQQNIIKNTG AVDYQNSTIG WTLAVNQNNY LMENAVITDT YEPVPGLTMV PNSLVVKDTT

TCAQLTLCKD FMVEITRNAD GETGFKVSFI GAYAKTSDAF HITYTTFFDV TELDANNPAL

DHYRNTAAID WTDEACNNHH SEDSKPFKPL PAFDLNAQKS GVYNAVTKET TWTIAVNLSN

NRLVDAFLTD PILTNQTYLA GSLKVYEGNT KPDGSVEKVK PTQPLTDITM EEPSEKNQNT

WRVDFPNDSR TYVIEFKTSV DEKVIEGSAS YDNTASYTNQ GSSRDVTGKV SIQHGGESVK

KGGEYHKDDP DHVYWHVMTN GAQSVLDDVV ITDTPSPNQV LDPESLVTYG TNVTEDGTIT

PDKSVILEEG KDYTLEVTTD NETGQQKIVV KMAHIEAPYY MEYRSLVTSS AAGSTDTVSN

QVSITGNGSE VVHGDDNGDV VVDIDHSGGH ATGTKGKIQL KKTAMDETTI LAGAHFQIWD

QAKTQVLREG TVDATGVITF GGLPQGQYIL VETKAPEGYT VSDELAKGRV ITIDEETSAE

GAQPTIIKND VNKVFLEKMD EKGKKLVNAR FKLEHAVTTP FTHWEEVPLA PDRTNANGQL

EVDSLKPGLY QFTEIEAPTG YLLDTTPKRF IVTQNTSGQI RDVHVKMLNY QGSAELIKKD

QACNPLAGAE FSVLDTTGQA VREHLVSDAN GKVTVTDLAP GKYQFVETKA PAGYLLNTEP

SAFTIAASDR GKPATVTATA NFVNYQCTAK LIKKDVNCHL LSGATFKVLD AKGETIQTGL

TTNNQGEIVA EHLAPCKYRF VETKAPTGYL LNTTPVPFEI AEKNAGKPAV VVASDNFVSY

KGAFQIVKTN SADQPLAGAV FELYDHNKQS LGTTATSGKD OKITERDLAP GTYYYKEIKA

PKLPDGADYT IYPELVKVEI RGDFKCDPET FQLGAFANFK GRAVFKKIDA NANPLPGTIF

KLYRIENGEK IFEREVTAEK DGSLANEDLG AGSYELDELD ATDGYIVNKQ PIYFVVKKNS

NDKQPLDELE FVNYQAEVMG RKVNEQGQTL AGAVFATYNA DEQNQPQCSP ITELNEAGEK

VSEITTDKTG EIYAKGLNEG HYVLVETKAP TGYLLDTTLH PFDVTAQLGK EQPIALGDLT

NYQGTAQLTK ENETGEALAG AVFKVIDETG QTVDGQTNLM SDKQGKVIAK NLAPGTYRFV

ETQAPTSYLL NETPSASFTI AKDNQGKPAT VVLKAPEINY QGAAKLVKID QQKNALAGAE

FKVTDAETGQ TVARSLRSDN QGLVQVNHLQ PGKYTFVETK APDGYQLSKQ AVAFTIAATA

KDKPELVNAG TFVNEKQPVS KKTKPNQPTT KQAARETGWL CLPKTNTQVN YFFVFIGLML

VGLASWLFYK KSKK

EF123-3 (SEQ lED NO:459)

CGAAGA GGTTAACAGC

GATCCCCAGT TAACGTTACG AGAACTCAAG CAAACCAGCC AGCAAGAAAT GACCTTAGCG

CTTCAAGGAA AAGCACAACC AGTAACACAA CAGGTTCTAG TOCATTATAG TGCCAATGTC

TCAATCAAAG CTGCACATTG GGCAGCGCCC AATAATACGC GCAAGATTCA AGTCGATGAC

CAGAAGAAAC AGATTCAAAT TGAATTGAAT CAGCAACCGT TACCAGATAC GTTAGTCTTA

ACGTTCAACC CTACACCTAC AGAAGATGTG ACGTTTTCTT ATCGACAACA GCAACCAGCG

TTGACGTTAA AGACTGGTAC TGATCCCACA GAATCAACGG CAATCACGAG TTCGCCAGCC

GCATCAGCGA ATGAACGTTC AACAGAAGAA GCATCTACAA ACTCCTCTGT TCCTCGTTCG

TCCGAAGAAA CTGTCGCCAG CACGACAAAA GCGATAGAAA GTAAAACAAC TGAATCGACG

ACTGTCAAAC CGCGCGTAGC AGGACCAACA GATATCACTG ATTATTTTAC AGGTCATGAA

ACAACGATTA TCCATAATTT TGAAGATCCG ATTTATTTAA ATCCTGATGG AACACCAGCA

ACACCGCCGT ATAAACAAGA TGTGACCATT CATTGGAACT TTAACTGGTC GATTCCACAA

GATGTGCGAG AACAAATGAA AGGAGOCCAT TACTTCCAGT TTCAATTACC TGGCAATTTG

AAACCTAATA AACCAGGTTC AGGTGATTTA GTTGATGCAG AAGGCAATGT CTATGGAACC

TACACAATTA GTGAAGATGG TACGGTTCGT TTTACCTTTA ATGAGCGAAT CACGTCTGAA

AGTGACATTC ACGGGGACTT TTCTTTAGAT ACTCATTTGA ATGATTCAGA TGGGCGGGGC

CCAGGAGATT GGGTGATTGA TATTCCTACA CAAGAAGATT TGCCGCCTGT AGTGATTCCA

ATTGTCCCAG ATACCGAACA ACAAATTGAT AAACAAGGCC ATTTTGATCG AACGCCCAAT

CCTAGTGCGA TTACTTGGAC GGTAGATATC AATCAAGCGA TGAAAGATCA AACAAATCCA

ACTGTGACGG AAACATGGCC AACAGGGAAT ACCTTTAAGT CCGTGAAAGT CTATGAGTTA

GTGATGAATC TTGATGGAAC AATTAAAGAA GTGGGTCGCG AACTTAGTCC AGATGAATAT

ACCGTTGATA AAAATGGCAA TGTGACGATT AAAGGTGACA CCAACAAAGC GTATCGTCTT

GAGTACCAAA CGACGATTGA CGAGGCGGTT ATTCCAGATG GCGGCCGCGA TGTGCCTTTT

AAAAATCACG CGACCTTAAC AAGTCATAAT AATCCAAATG GGTTAGATGC TGAAGCAACT

GTTACCGCCA CATATGGCAA AATGTTAGAC AAGCGCAATA TAGATTACGA CGAAGCCAAT

CAAGAATTCA CTTCGGAAAT TAACTACAAC TATGGTGAAC AAACCATTCC AAAAGACCAA

GCAGTCATTA CAGACACAAT GGGCGATAAT TTAACGTTTG AACCAGATTC TTTACATTTA

TATTCAGTGA CATTTGATGA CAAAGGAAAT GAAGTCGTTG GAGCAGAACT TGTGGAAGGA

AAAGATTACA AAGTGGTAAT CAACGGAGAC GGTTCCTTTG CAATTGACTT TTTACATGAT

GTGACTGGCG CAGTCAAGAT TGATTATAAA ACCAAAGTTG ATGGAATTGT CGAAGGCGAT

GTTGCCGTGA ATAATCGTCT GGATGTTGGC ACTGGTCAGC ATTCAGAAGA TGATGGCACA

GCCAGTCAAC AAAATATTAT TAAAAACACT GGTGCAGTTG ATTATCAAAA TTCAACGATT

GGTTGGACGT TAGCTGTGAA TCAAAATAAT TATTTGATGG AAAATGCCGT GATTACGGAT

ACGTACGAAC CAGTTCCTGG CTTAACTATG GTACCCAATT CGTTGGTTGT CAAAGATACA

ACCACTGGTG CTCAGTTGAC GTTAGGCAAG GATTTCATGG TAGAAATAAC TCGTAATGCA

GATGGTGAAA CAGGCTTTAA GGTAAGTTTT ATAGGGGCGT ATGCCAAAAC AAGTGATCCC

TTCCACATAA CTTATACTAC CTTTTTCGAT GTTACCGAGT TAGACGCTAA CAATCCTGCG

TTGGACCATT ATCGAAATAC CGCTGCCATT GATTGG

EF123-4 (SEQ ID NO:460)

EEVNSD

GQLTLGEVKQ TSQQEMTLAL QGKAQPVTQE VVVHYSANVS IKAAHWAAPN NTRKIQVDDQ

KKQIQIELNQ QALADTLVLT LNPTATEDVT FSYGQQQRAL TLKTGTDPTE STAITSSPAA

SANEGSTEEA STNSSVPRSS EETVASTTKA IESKTTESTT VKPRVAGPTD ISDYFTGDET

TTIDNFEDPI YLNPDGTPAT PPYKEDVTIH WNFNWSIPED VREQMKACDY FEFQLPCNLK

PNKPGSGDLV DAEGNVYGTY TISEDGTVRF TFNERITSES DIHGDFSLDT HLNDSDGRGP

GDWVTDTPTQ EDLPPVVIPI VPDTEQQIDK QGHFDRTPNP SAITWTVDIN QAMKDQTNPT

VTETWPTGNT FKSVKVYELV MNLDGTIKEV GRELSPDEYT VDKNGNVTIK GDTNKAYRLE

YQTTIDEAVI PDGGGDVPFK NHATLTSDNN PNGLDAEATV TATYGKMLDK RNIDYDEANQ

EFTWETNYNY GEQTTPKDQA VITDTMGDNL TFEPDSLHLY SVTFDDKGNE VVGAELVEGK

DYKVVINGDG SFAIDFLHDV TGAVKIDYKT KVDGIVEGDV AVNNRVDVGT GQHSEDDGTA

SQQNIIKNTG AVDYQNSTIG WTLAVNQNNY LMENAVTTDT YEPVPGLTMV PNSLVVKDTT

TGAQLTLGKD FMVEITRNAD GETGFKVSFI GAYAKTSDAF HITYTTFFDV TELDANNPAL

DHYRNTAAID W

EF124-1 (SEQ ID NO:461)

TAAAATAAAA AATTGGTACG AAGTGAACGT TCTCTTCTAT GTGTCGTTAG TAGAGGAAGG

ATGAAAGAAA TGAGAAAGAA TGGTCCAATG GTAAACCGTT GGCTCTACGG GTTGATGTGT

TTGTTACTTG TTCTAAATTA TGGCACACCA CTCATGGCTT TGGCGGAAGA GGTTAACAGC

GATGGCCAGT TAACGTTAGG AGAAGTGAAG CAAACCAGCC AGCAAGAAAT GACCTTAGCG

CTTCAAGGAA AAGCACAACC AGTAACACAA GAGGTTGTAG TGCATTATAG TGCCAATGTG

TCAATCAAAG CTGCACATTG GGCAGCGCCC AATAATACGC GCAAGATTCA AGTGGATGAC

CAGAAGAAAC AGATTCAAAT TGAATTGAAT CAGCAAGCCT TACCAGATAC GTTAGTCTTA

ACGTTGAACC CTACAGCTAC AGAAGATGTG ACGTTTTCTT ATGGACAACA GCAACGAGCG

TTGACGTTAA AGACTGGTAC TGATCCGACA GAATCAACGG CAATCACGAG TTCGCCAGCC

GCATCAGCGA ATGAAGGTTC AACAGAAGAA GCATCTACAA ACTCCTCTGT TCCTCGTTCG

TCCGAAGAAA CTGTCGCCAG CACGACAAAA GCGATAGAAA GTAAAACAAC TGAATCGACG

ACTGTCAAAC CGCGCGTAGC AGGACCAACA GATATCAGTG ATTATTTTAC AGGTGATGAA

ACAACGATTA TCGATAATTT TGAAGATCCG ATTTATTTAA ATCCTGATGG AACACCAGCA

ACACCGCCGT ATAAAGAAGA TGTGACCATT CATTGGAACT TTAACTGGTC GATTCCAGAA

GATGTGCGAG AACAAATGAA AGCAGGCGAT TACTTCGAGT TTCAATTACC TGGCAATTTG

AAACCTAATA AACCAGGTTC AGGTGATTTA GTTGATGCAG AAGGCAATGT CTATGGAACC

TACACAATTA GTGAAGATGG TACGGTTCGT TTTACCTTTA ATGAGCGAAT CACGTCTGAA

AGTGACATTC ACGGGGACTT TTCTTTAGAT ACTCATTTGA ATGATTCAGA TCGGCGGGGC

CCAGGAGATT GGGTGATTGA TATTCCTACA CAAGAAGATT TGCCGCCTGT AGTGATTCCA

ATTGTCCCAG ATACCGAACA ACAAATTGAT AAACAAGGCC ATTTTGATCG AACGCCCAAT

CCTAGTGCGA TTACTTGGAC GGTAGATATC AATCAAGCGA TGAAAGATCA AACAAATCCA

ACTGTGACGG AAACATGGCC AACAGGGAAT ACCTTTAAGT CCGTGAAAGT CTATGAGTTA

GTGATGAATC TTGATGGAAC AATTAAAGAA GTGGGTCGCC AACTTAGTCC AGATGAATAT

ACCGTTGATA AAAATGGCAA TGTGACGATT AAAGGTGACA CCAACAAAGC GTATCGTCTT

GAGTACCAAA CGACGATTGA CGAGGCGGTT ATTCCAGATG GCGGCGGCGA TGTGCCTTTT

AAAAATCACG CGACGTTAAC AAGTGATAAT AATCCAAATG GGTTAGATGC TGAAGCAACT

GTTACCGCCA CATATGGCAA AATGTTAGAC AAGCGCAATA TAGATTACCA CGAAGCCAAT

CAAGAATTCA CTTGGGAAAT TAACTACAAC TATGGTGAAC AAACCATTCC AAAAGACCAA

GCAGTCATTA CAGACACAAT GGGGGATAAT TTAACGTTTG AACCAGATTC TTTACATTTA

TATTCAGTGA CATTTGATGA CAAAGGAAAT GAAGTCGTTG GAGCAGAACT TGTGGAAGGA

AAAGATTACA AAGTGGTAAT CAACGGAGAC GGTTCCTTTG CAATTGACTT TTTACATGAT

GTGACTGGCG CAGTCAAGAT TGATTATAAA ACCAAAGTTG ATGGAATTGT CGAAGGCGAT

GTTGCCGTGA ATAATCGTGT GGATGTTGGC ACTGGTCAGC ATTCAGAAGA TGATGGCACA

GCCAGTCAAC AAAATATTAT TAAAAACACT GGTGCAGTTG ATTATCAAAA TTCAACGATT

GGTTGGACGT TAGCTGTGAA TCAAAATAAT TATTTGATGG AAAATGCCGT GATTACGGAT

ACGTACGAAC CAGTTCCTGG CTTAACTATG GTACCCAATT CGTTGGTTGT CAAAGATACA

ACCACTGGTG CTCAGTTGAC GTTAGGCAAG GATTTCATGG TAGAAATAAC TCGTAATGCA

GATGGTGAAA CACGCTTTAA GGTAAGTTTT ATAGGGGCGT ATGCCAAAAC AAGTGATGCC

TTCCACATAA CTTATACTAC CTTTTTCGAT GTTACCGAGT TAGACGCTAA CAATCCTGCG

TTGGACCATT ATCCAAATAC CGCTGCCATT GATTGGACGG ATCAAGCAGG AAACAATCAT

CATTCAGAAG ATAGTAAACC GTTTAAACCT TTACCTGCTT TTGATTTAAA TGCGCAAAAA

AGCGGTGTTT ACAATGCCGT CACCAAAGAA ATCACTTGGA CGATTGCGGT TAATTTAAGT

AATAATCGTT TAGTCGACGC CTTTTTGACG GATCCAATTT TAACCAATCA AACCTATTTG

GCTGGGAGCT TGAAAGTCTA TGAAGGCAAT ACAAAGCCAG ATGGTTCGGT TGAAAAAGTG

AAACCAACGC AACCGTTGAC GGATATCACA ATGGAAGAAC CAAGCGAGAA AAACCAAAAT

ACTTGGCGTG TTGATTTTCC TAATGATAGT CGTACGTATG TGATTGAATT TAAGACGTCT

GTTGATGAAA AAGTTATCGA AGGTTCGGCT AGTTATGACA ATACCGCATC TTATACAAAC

CAAGGTTCTT CACGTGATGT GACAGGAAAA GTTTCTATTC AACATGGTGG CGAATCAGTG

AAAAAAGGTG GCGAATACCA CAAAGATGAT CCAGATCATG TGTACTGGCA TGTAATGATC

AATGGCGCCC AATCGGTTTT AGACGATGTG GTTATTACTG ATACACCCTC ACCAAACCAA

GTGCTAGATC CCGAGTCATT GGTGATTTAC GGTACCAACG TAACAGAAGA CGGAACTATT

ACGCCAGATA AATCTGTTAT TTTAGAAGAA GGAAAAGATT ACACACTGGA AGTTACCACC

GATAATGAAA CAGGACAACA AAAAATTGTC GTTAAAATGG CCCATATTGA AGCACCTTAT

TATATGGAAT ATCGTAGTTT AGTGACTTCT TCAGCGGCGG GGAGTACAGA CACGGTATCC

AACCAAGTGT CAATTACTGG AAATGGTTCA GAAGTCGTTC ATGGGGATGA CAATGGCGAT

GTGGTCGTTG ACATTGATCA CAGTGGCGGG CATGCCACAG GGACTAAAGG CAAAATTCAG

CTGAAGAAAA CAGCCATGGA TGAGACGACT ATTTTAGCAG GCGCCCATTT CCAAATTTGG

GACCAAGCTA AAACACAAGT CCTACGTGAA GGTACAGTAG ATGCCACCGG GGTTATCACA

TTTGGTGGGT TGCCACAAGG GCAATACATT TTGGTGGAGA CAAAAGCACC AGAAGGCTAT

ACAGTTTCGG ACGAATTAGC TAAAGGCCGA GTCATTACTA TTGATGAAGA AACTTCAGCC

GAAGGAGCAC AACCAACCAT TATTAAAAAC GATGTCAATA AAGTATTTTT AGAAAAAATG

GATGAGAAGG GTAAAAAGTT AGTCAATGCT CGCTTTAAAT TAGAGCATGC CGTAACCACG

CCGTTTACTC ATTGGGAAGA AGTTCCCCTT GCGCCGGATC GAACCAACGC GAATGGCCAG

TTAGAGGTGG ATAGTTTAAA ACCAGGGCTT TATCAGTTCA CAGAAATCGA AGCACCGACA

GGCTATCTTT TAGACACCAC CCCCAAACGA TTCATCGTGA CACAAAATAC GAGCGGACAA

ATTCGTGATG TTCATGTCAA AATGCTTAAT TACCAAGGTT CTGCTGAACT AATTAAAAAA

GACCAAGCAG GCAATCCATT AGCAGGTGCT GAATTTTCAG TCCTTGACAC CACAGGACAA

GCAGTTCGAG AACACTTAGT TTCGGATGCA AACGGAAAAG TCACAGTGAC GGATTTAGCC

CCAGGAAAAT ATCAATTTGT GGAAACCAAA GCGCCAGCAG GGTACCTTTT AAACACTGAA

CCAAGTGCTT TCACGATTGC AGCAAGCGAT CGGGGCAAAC CAGCAACAGT TATAGCAACG

GCTAACTTTG TTAACTATCA AGGCACGGCT AAATTAATCA AAAAAGATGT GAATGGACAC

TTATTAAGTG GTGCGACATT TAAAGTGCTT CATGCGAAGG GAGAAACGAT TCAAACAGGC

TTGACGACAA ATAATCAAGG GGAAATTGTT GCAGAGCACT TAGCCCCAGG AAAATATCGC

TTTGTAGAAA CCAAAGCGCC AACAGGCTAT TTATTAAATA CCACGCCAGT CCCATTTGAA

ATTGCTGAGA AAAATGCTGG TAAACCAGCG GTCGTGGTTG CTAGTGACAA CTTTGTGACT

TACAAAGGGG CTTTCCAAAT CGTGAAAACG AATAGCGCAG ACCAACCATT AGCAGGTGCT

GTTTTTGAAT TATATGATCA CAATAAACAA TCATTAGGGA TTACAGCAAC GAGTGGCAAA

GATGGCAAAA TTATCTTTAG AGACTTGGCG CCAGGTACCT ATTATTACAA AGAAATCAAA

GCACCAAAAT TACCAGATOG CGCAGATTAT ATTATTTATC CTGAATTAGT AAAAGTAGAA

ATTCGTGGTG ATTTCAAAGG TGATCCGGAG ATTTTCCAAT TAGGGGCCTT CGCCAATTTC

AAAGGACGCG CCGTCTTTAA GAAAATTGAT GCCAATGCGA ACCCACTTCC AGGAACGATT

TTTAAATTGT ATCGAATCGA AAACGGGGAA AAAATCTTTG AAAGAGAAGT AACTGCTGAA

AAAGATGGTT CATTGGCTAT GGAGGATTTA GGTGCTGGTA GCTATGAATT AGATGAACTG

GATGCAACGG ATGGCTATAT CGTCAATAAA CAACCCATTT ATTTTGTAGT GAAGAAGAAT

TCAAATGATA AACAACCACT AGATGAGTTA GAGTTTGTAA ATTATCAAGC AGAAGTAATG

GGACGTAAAG TCAACGAGCA AGGTCAAACC TTAGCGGGTG CAGTTTTTGC AATTTACAAT

GCCGATGAGC AGAATCAGCC CCAAGGTTCA CCGATAACAT TCTTGAATCG TGCAGGAGAA

AAAGTTTCTG AAATAACAAC GGATAAGACT GGCGAAATTT ACGCTAAAGG GCTAAATGAA

GGGCATTACG TTTTAGTGGA AACGAAAGCA CCAACAGGCT ATCTGTTAGA CACAACGCTA

CATCCATTTG ATGTAACCGC CCAATTAGGA AAAGAGCAGC CAATTGCTTT AGGCGATCTT

ATCAATTATC AAGGAACTGC TCAATTAACC AAAGAAAACG AAACAGGTGA AGCATTGGCA

GGTGCGCTGT TTAAGGTCAT TGATGAAACA GGGCAAACCG TAGATGGACA AACCAATCTG

ATGTCTGACA AGCAAGGCAA AGTCATTGCG AAAAACTTAG CACCGGGAAC GTATCGTTTT

GTGGAGACAC AAGCGCCAAC TAGCTATCTT CTTAATGAAA CGCCAAGCCC AAGCTTTACG

ATTGCCAAAG ACAACCAAGG CAAACCAGCC ACTGTGGTAC TTAAAGCACC TTTTATTAAT

TACCAAGGTG CTGCCAAGCT GGTGAAAATT GATCAGCAAA AGAATGCCTT AGCAGGTGCT

GAATTTAAAG TGACAGATGC AGAGACAGGG CAAACTGTCG CTCGTTCATT ACGTTCTGAC

AACCAAGGGT TAGTTCAAGT GAACCACTTA CAACCAGGAA AATATACCTT TGTGGAAACA

AAAGCACCGG ATGGTTACCA ACTGTCTAAG CAAGCTGTCG CATTCACTAT TGCGGCAACA

GCGAAAGACA AACCTGAACT CGTGAATGCG GGCACGTTTG TTAACGAGAA ACAACCTGTA

TCCAAAAAAA CAAAACCAAA TCAGCCAACA ACGAAACAAG CAGCTAGAGA GACAGGTTGG

CTTGGTTTAC CGAAAACCAA CACACAAGTC AATTACTTCT TTGTCTTTAT CGGCCTCATG

TTGGTCGGTT TGGCAAGTTG GCTCTTCTAT AAAAAGAGCA AGAAATAA

EF124-2 (SEQ ID NO:462)

MRKNGPMV NRWLYGLMCL LLVLNYGTPL MALAEEVNSD

GQLTLGEVKQ TSQQEMTLAL QGKAQPVTQE VVVHYSANVS IKAAHWAAPN NTRKIQVDDQ

KKQIQIELNQ QALADTLVLT LNPTATEDVT FSYGQQQRAL TLKTGTDPTE STAITSSPAA

SANEGSTEEA STNSSVPRSS EETVASTTKA IESKTTESTT VKPRVAGFTD ISDYFTGDET

TITDNFEDPI YLNPDGTPAT PPYKEDVTIH WNFNWSIPED VREQMKAGDY FEFQLPGNLK

PNKPGSGDLV DAEGNVYGTY TISEDGTVRF TFNERITSES DIHGDFSLDT HLNDSDGRGP

GDWVIDIPTQ EDLPPVVIPT VPDTEQQIDK QGHFDRTPNP SAITWTVDIN QAMKDQTNPT

VTETWPTGNT FKSVKVYELV MNLDGTIKEV GRELSPDEYT VDKNGNVTIK GDTNKAYRLE

YQTTIDEAVI PDGGGDVPFK NHATLTSDNN PNGLDAEATV TATYGKMLDK RNIDYDEANQ

EFTWEINYNY GEQTTPKDQA VTTDTMGDNL TFEPDSLHLY SVTFDDKGNE VVGAELVEGK

DYKVVINGDG SFAIDFLHDV TGAVKIDYKT KVDGIVEGDV AVNNRVDVGT GQHSEDDGTA

SQQNIIKNTG AVDYQNSTIG WTLAVNQNNY LMENAVITDT YEPVPGLTMV PNSLVVKDTT

TGAQLTLGKD FMVEITRNAD GETGFKVSFI GAYAKTSDAF HTTYTTFFDV TELDANNPAL

DHYRNTAAID WTDEAGNNHH SEDSKPFKPL PAFDLNAQKS GVYNAVTKEI TWTIAVNLSN

NRLVDAFLTD PILTNQTYLA GSLKVYEGNT KPDGSVEKVK PTQPLTDITM EEPSEKNQNT

WRVDFPNDSR TYVIEFKTSV DEKVIEGSAS YDNTASYTNQ GSSRDVTGKV SIQHGGESVK

KGGEYHKDDP DHVYWHVMIN GAQSVLDDVV ITDTPSPNQV LDPESLVIYG TNVTEDGTIT

PDKSVILEEG KDYTLEVTTD NETGQQKIVV KMAHIEAPYY MEYRSLVTSS AAGSTDTVSN

QVSTTGNGSE VVHGDDNGDV VVDIDHSGGH ATGTKGKIQL KKTAMDETTI LAGAHFQIWD

QAKTQVLREG TVDATGVTTF CGLPQGQYIL VETKAPEGYT VSDELAKGRV ITIDEETSAE

GAQPTIIKND VNKVFLEKMD EKGKKLVNAR FKLEHAVTTP FTHWEEVPLA PDRTNANCQL

EVDSLKPGLY QFTEIEAPTG YLLDTTPKRF IVTQNTSGQI RDVHVKMLNY QGSAELTKKD

QAGNPLAGAE FSVLDTTGQA VREHLVSDAN GKVTVTDLAP GKYQFVETKA PAGYLLNTEP

SAFTTAASDR GKPATVIATA NFVNYQGTAK LIKKDVNGHL LSGATFKVLD AKCETIQTGL

TTNKQCEIVA EHLAPGKYRF VETKAPTGYL LNTTPVPFEI AEKNAGKPAV VVASDNFVSY

KGAFQIVKTN SADQPLAGAV FELYDHNKQS LGITATSGKD GKTIFRDLAP GTYYYKEIKA

PKLPDCADYI IYPELVKVEI RGDFKGDPEI FQLCAFANFK GPAVFKKIDA NANPLPGTIF

KLYRIENGEK IFEREVTAEK DGSLAMEDLG AGSYELDELD ATDGYIVNKQ PIYFVVKKNS

NDKQPLDELE FVNYQAEVMC RKVNEQGQTL ACAVEATYNA DEQNQPQGSP ITFLNRACEK

VSETTTDKTG EIYAKGLNEG HYVLVETKAP TGYLLDTTLH PFDVTAQLGK EQPIALGDLI

NYQGTAQLTK ENETGEALAG AVFKVTDETG QTVDGQTNLM SDKQGKVIAK NLAPGTYRFV

ETQAPTSYLL NETPSASFTT AKDNQGKPAT VVLKAPFINY QCAAKLVKID QQKNALAGAE

FKVTDAETGQ TVARSLRSDN QGLVQVNHLQ PGKYTFVETK APDGYQLSKQ AVAFTIAATA

KDKPELVNAG TFVNEKQPVS KKTKPNQPTT KQAARETGWL GLPKTNTQVN YFFVFIGLML

VGLASWLFYK KSKK

EF124-3 (SEQ ID NO:463)

TGCCTTCCACATAACTTATACTACCTTTTTGACG GATCCAATTT TAACCAATCA AACCTATTTG

GCTGGGAGCT TGAAAGTCTA TGAAGGCAAT ACAAAGCCAG ATGGTTCGGT TGAAAAAGTG

AAACCAACGC AACCCTTGAC GCATATCACA ATGGAAGAAC CAAGCGAGAA AAACCAAAAT

ACTTGCCGTG TTGATTTTCC TAATGATAGT CGTACGTATG TGATTGAATT TAAGACGTCT

GTTGATGAAA AAGTTATCGA AGGTTCGGCT AGTTATGACA ATACCGCATC TTATACAAAC

CAAGGTTCTT CACGTGATGT GACAGGAAAA CTTTCTATTC AACATGGTCC CGAATCAGTG

AAAAAAGGTC GCGAATACCA CAAAGATGAT CCACATCATG TCTACTGCCA TGTAATGATC

AATGGCGCCC AATCGGTTTT AGACGATGTG GTTATTACTG ATACACCCTC ACCAAACCAA

GTGCTAGATC CCGAGTCATT GGTGATTTAC GGTACCAACG TAACAGAAGA CGGAACTATT

ACOCCAGATA AATCTCTTAT TTTAGAAGAA CGAAAAGATT ACACACTGGA AGTTACCACC

GATAATGAAA CAGGACAACA AAAAATTGTC GTTAAAATGG CCCATATTGA AGCACCTTAT

TATATGGAAT ATCGTAGTTT AGTGACTTCT TCAGCCGCGG OGACTACAGA CACGGTATCC

AACCAAGTGT CAATTACTGG AAATGGTTCA GAAGTCGTTC ATGGGGATGA CAATGGCGAT

GTCGTCGTTG ACATTCATCA CAGTGCCGGG CATGCCACAG GGACTAAAGG CAAAATTCAG

CTGAAGAAAA CAGCCATCGA TOAGACCACT ATTTTAGCAG GCGCCCATTT CCAAATTTGG

GACCAAGCTA AAACACAAGT CCTACGTGAA GGTACACTAG ATGCCACCGG GGTTATCACA

TTTGGTGGGT TGCCACAAGG GCAATACATT TTGGTGGAGA CAAAAGCACC AGAAGGCTAT

ACAGTTTCGG ACGAATTAGC TAAAGGCCGA GTCATTACTA TTGATGAAGA AACTTCAGCC

GAAGGAGCAC AACCAACCAT TATTAAAAAC CATGTCAATA AAGTATTTTT AGAAAAAATG

GATGAGAAGG GTAAAAAGTT AGTCAATGCT CGCTTTAAAT TAGAGCATGC CGTAACCACG

CCGTTTACTC ATTCGGAAGA AGTTCCCCTT GCGCCGGATC GAACCAACGC GAATGGCCAG

TTAGAGGTGG ATAGTTTAAA ACCAGCGCTT TATCAGTTCA CAGAAATCGA AGCACCGACA

GGCTATCTTT TAGACACCAC CCCCAAACGA TTCATCGTGA CACAAAATAC GAGCGGACAA

ATTCGTGATG TTCATGTCAA AATGCTTAAT TACCAAGGTT CTGCTGAACT AATTAAAAAA

GACCAAGCAG GCAATCCATT AGCAGGTGCT CAATTTTCAG TCCTTGACAC CACAGGACAA

GCAGTTCGAG AACACTTAGT TTCGGATGCA AACGGAAAAG TCACAGTGAC GGATTTAGCC

CCAGGAAAAT ATCAATTTGT GGAAACCAAA GCGCCAGCAG GGTACCTTTT AAACACTGAA

CCAAGTGCTT TCACGATTGC AGCAAGCGAT CGGGGCAAAC CAGCAACAGT TATAGCAACG

GCTAACTTTG TTAACTATCA AGGCACGGCT AAATTAATCA AAAAAGATGT GAATGGACAC

TTATTAAGTG GTGCGACATT TAAAGTGCTT GATGCGAAGG GAGAAACGAT TCAAACAGGC

TTGACGACAA ATAATCAAGG G

EF124-4 (SEQ ID NO:464)

AF HTTYTTFFDV TELDANNPAL

DHYRNTAAID WTDEAGNNHH SEDSKPFKPL PAFDLNAQKS GVYNAVTKEI TWTIAVNLSN

NRLVDAFLTD PILTNQTYLA GSLKVYEGNT KPDGSVEKVK PTQPLTDITM EEPSEKNQNT

WRVDFPNDSR TYVIEFKTSV DEKVIEGSAS YDNTASYTNQ GSSRDVTGKV SIQHGGESVK

KGGEYHKDDP DHVYWHVMTN GAQSVLDDVV ITDTPSPNQV LDPESLVIYG TNVTEDGTIT

PDKSVILEEG KDYTLEVTTD NETGQQKIVV KMAHIEAPYY MEYRSLVTSS AAGSTDTVSN

QVSITGNGSE VVHGDDNGDV VVDIDHSGGH ATGTKGKIQL KKTAMDETTI LAGAHFQIWD

QAKTQVLREG TVDATGVITF GGLPQGQYIL VETKAPEGYT VSDELAKGRV ITIDEETSAE

GAQPTIIKND VNKVFLEKMD EKGKKLVNAR FKLEHAVTTP FTHWEEVPLA PDRTNANGQL

EVDSLKPGLY QFTEIEAPTG YLLDTTPKRF IVTQNTSGQI RDVHVKMLNY QGSAELIKKD

QAGNPLAGAE FSVLDTTGQA VREHLVSDAN GKVTVTDLAP GKYQFVETKA PAGYLLNTEP

SAFTIAASDR GKPATVTATA NFVNYQGTAK LIKKDVNGHL LSGATFKVLD AKGETTQTGL

TTNNQG

EF125-1 (SEQ ID NO:465)

TAAAATAAAA AATTGGTACG AAGTGAACGT TCTCTTCTAT CTGTCGTTAG TAGAGGAAGG

ATGAAAGAAA TGAGAAAGAA TGGTCCAATG GTAAACCGTT GGCTCTACGG GTTGATGTGT

TTGTTACTTG TTCTAAATTA TCGCACACCA CTCATGGCTT TGGCGGAAGA GGTTAACAGC

GATGGCCAGT TAACGTTAGG AGAAGTGAAG CAAACCAGCC AGCAAGAAAT GACCTTAGCG

CTTCAAGGAA AAGCACAACC AGTAACACAA GAGGTTGTAG TGCATTATAG TGCCAATGTG

TCAATCAAAG CTGCACATTG GGCAGCGCCC AATAATACGC GCAAGATTCA AGTGGATGAC

CACAAGAAAC AGATTCAAAT TGAATTGAAT CAGCAAGCGT TACCAGATAC GTTAGTCTTA

ACGTTGAACC CTACAGCTAC AGAAGATGTG ACGTTTTCTT ATGGACAACA GCAACGAGCG

TTGACGTTAA AGACTGGTAC TGATCCGACA GAATCAACGG CAATCACGAG TTCGCCAGCC

GCATCAGCGA ATGAAGGTTC AACAGAAGAA GCATCTACAA ACTCCTCTGT TCCTCGTTCG

TCCGAAGAAA CTGTCGCCAG CACGACAAAA GCGATAGAAA GTAAAACAAC TGAATCGACG

ACTGTCAAAC CGCGCGTAGC AGGACCAACA GATATCAGTG ATTATTTTAC AGGTGATGAA

ACAACGATTA TCGATAATTT TGAAGATCCG ATTTATTTAA ATCCTGATGG AACACCAGCA

ACACCGCCCT ATAAAGAAGA TGTGACCATT CATTGGAACT TTAACTGGTC GATTCCAGAA

GATGTGCGAG AACAAATGAA AGCAGGCGAT TACTTCGAGT TTCAATTACC TGGCAATTTG

AAACCTAATA AACCAGGTTC AGGTGATTTA GTTGATGCAG AAGGCAATGT CTATGGAACC

TACACAATTA GTGAAGATGG TACGGTTCGT TTTACCTTTA ATGAGCGAAT CACGTCTGAA

AGTGACATTC ACGGGGACTT TTCTTTAGAT ACTCATTTGA ATGATTCAGA TGGGCGGGGC

CCAGGAGATT GGGTGATTGA TATTCCTACA CAAGAAGATT TGCCGCCTGT AGTGATTCCA

ATTGTCCCAG ATACCGAACA ACAAATTGAT AAACAAGGCC ATTTTGATCG AACGCCCAAT

CCTAGTGCGA TTACTTGGAC GGTAGATATC AATCAAGCGA TGAAAGATCA AACAAATCCA

ACTGTGACGG AAACATGGCC AACAGGGAAT ACCTTTAAGT CCGTGAAAGT CTATGAGTTA

GTGATGAATC TTGATGGAAC AATTAAAGAA GTGGGTCGCG AACTTAGTCC AGATGAATAT

ACCGTTGATA AAAATGGCAA TGTGACGATT AAAGGTGACA CCAACAAAGC GTATCGTCTT

GAGTACCAAA CGACGATTGA CGAGGCGGTT ATTCCAGATG GCGGCGGCGA TGTGCCTTTT

AAAAATCACG CGACGTTAAC AAGTGATAAT AATCCAAATG GGTTAGATGC TGAAGCAACT

GTTACCGCCA CATATGGCAA AATGTTAGAC AAGCGCAATA TAGATTACGA CGAAGCCAAT

CAAGAATTCA CTTGGCAAAT TAACTACAAC TATGGTGAAC AAACCATTCC AAAAGACCAA

GCAGTCATTA CAGACACAAT GGGGGATAAT TTAACGTTTG AACCAGATTC TTTACATTTA

TATTCAGTGA CATTTGATGA CAAAGGAAAT GAAGTCGTTG GAGCAGAACT TGTGGAAGGA

AAAGATTACA AAGTGGTAAT CAACGGAGAC GGTTCCTTTG CAATTGACTT TTTACATGAT

GTGACTGGCG CAGTCAAGAT TGATTATAAA ACCAAAGTTG ATGGAATTGT CGAAGGCGAT

GTTGCCGTGA ATAATCGTGT GGATGTTGGC ACTGGTCAGC ATTCAGAAGA TGATGGCACA

GCCAGTCAAC AAAATATTAT TAAAAACACT GGTGCAGTTG ATTATCAAAA TTCAACCATT

GGTTGGACGT TAGCTGTGAA TCAAAATAAT TATTTGATGG AAAATGCCGT GATTACGGAT

ACGTACGAAC CAGTTCCTGG CTTAACTATG GTACCCAATT CGTTGGTTGT CAAAGATACA

ACCACTGGTG CTCAGTTGAC GTTAGGCAAG GATTTCATGG TAGAAATAAC TCGTAATGCA

GATGGTGAAA CAGCCTTTAA GGTAAGTTTT ATAGGGGCGT ATGCCAAAAC AAGTGATGCC

TTCCACATAA CTTATACTAC CTTTTTCGAT GTTACCGAGT TAGACGCTAA CAATCCTGCG

TTGGACCATT ATCGAAATAC CGCTGCCATT GATTGGACGG ATGAAGCAGG AAACAATCAT

CATTCAGAAG ATAGTAAACC GTTTAAACCT TTACCTGCTT TTGATTTAAA TGCGCAAAAA

AGCGGTGTTT ACAATGCCGT CACCAAAGAA ATCACTTGGA CGATTGCGGT TAATTTAAGT

AATAATCGTT TAGTCGACGC CTTTTTGACG GATCCAATTT TAACCAATCA AACCTATTTG

GCTGGGAGCT TCAAAGTCTA TGAAGGCAAT ACAAAGCCAG ATGGTTCGGT TGAAAAAGTG

AAACCAACGC AACCGTTGAC GGATATCACA ATGGAAGAAC CAAGCGAGAA AAACCAAAAT

ACTTGGCGTG TTGATTTTCC TAATGATAGT CGTACGTATG TGATTGAATT TAAGACGTCT

GTTGATGAAA AAGTTATCGA AGGTTCGGCT AGTTATGACA ATACCGCATC TTATACAAAC

CAAGGTTCTT CACGTGATGT GACAGGAAAA GTTTCTATTC AACATGGTGG CGAATCAGTG

AAAAAAGGTG GCGAATACCA CAAAGATGAT CCAGATCATG TGTACTGGCA TGTAATGATC

AATGGCGCCC AATCGGTTTT AGACGATGTG GTTATTACTG ATACACCCTC ACCAAACCAA

GTGCTAGATC CCGAGTCATT GGTGATTTAC GGTACCAACG TAACAGAAGA CGGAACTATT

ACGCCAGATA AATCTGTTAT TTTAGAAGAA GGAAAAGATT ACACACTGGA AGTTACCACC

GATAATGAAA CAGGACAACA AAAAATTGTC GTTAAAATGG CCCATATTGA AGCACCTTAT

TATATGGAAT ATCGTAGTTT AGTGACTTCT TCAGCGGCGG GGAGTACAGA CACGGTATCC

AACCAAGTGT CAATTACTGG AAATGGTTCA GAAGTCGTTC ATGGGGATGA CAATGGCGAT

GTGGTCGTTC ACATTGATCA CAGTGGCGGG CATGCCACAC GGACTAAAGC CAAAATTCAG

CTGAAGAAAA CAGCCATGGA TGAGACGACT ATTTTAGCAG GCGCCCATTT CCAAATTTGG

GACCAAGCTA AAACACAAGT CCTACGTGAA GGTACAGTAG ATGCCACCGG GGTTATCACA

TTTGGTGGGT TGCCACAAGG GCAATACATT TTGGTGGAGA CAAAAGCACC AGAAGGCTAT

ACAGTTTCCG ACGAATTAGC TAAAGGCCGA GTCATTACTA TTGATCAAGA AACTTCAGCC

GAAGGAGCAC AACCAACCAT TATTAAAAAC GATGTCAATA AAGTATTTTT AGAAAAAATG

GATGACAAGG GTAAAAAGTT AGTCAATGCT CGCTTTAAAT TAGAGCATGC CGTAACCACG

CCGTTTACTC ATTGGGAAGA AGTTCCCCTT GCGCCGGATC GAACCAACGC GAATGGCCAG

TTAGAGGTGG ATAGTTTAAA ACCAGGGCTT TATCAGTTCA CAGAAATCGA AGCACCGACA

GGCTATCTTT TAGACACGAC CCCCAAACGA TTCATCGTGA CACAAAATAC GAGCGGACAA

ATTCGTGATG TTCATGTCAA AATGCTTAAT TACCAAGGTT CTGCTGAACT AATTAAAAAA

GACCAAGCAG GCAATCCATT AGCAGGTGCT GAATTTTCAG TCCTTGACAC CACAGGACAA

GCAGTTCGAG AACACTTAGT TTCGGATGCA AACGGAAAAG TCACAGTGAC GGATTTAGCC

CCAGGAAAAT ATCAATTTGT GGAAACCAAA GCGCCAGCAG GGTACCTTTT AAACACTGAA

CCAAGTGCTT TCACGATTGC AGCAAGCGAT CGGGGCAAAC CAGCAACAGT TATAGCAACG

GCTAACTTTG TTAACTATCA AGGCACGGCT AAATTAATCA AAAAAGATGT GAATGGACAC

TTATTAAGTG GTGCGACATT TAAAGTGCTT GATGCGAAGG GAGAAACGAT TCAAACAGGC

TTGACGACAA ATAATCAAGG GGAAATTGTT GCAGAGCACT TAGCCCCAGG AAAATATCGC

TTTGTAGAAA CCAAAGCGCC AACAGGCTAT TTATTAAATA CCACGCCACT CCCATTTGAA

ATTGCTGAGA AAAATGCTGG TAAACCAGCG GTCGTGGTTG CTAGTGACAA CTTTGTGAGT

TACAAAGGGG CTTTCCAAAT CGTGAAAACG AATAGCGCAG ACCAACCATT AGCAGGTGCT

GTTTTTGAAT TATATGATCA CAATAAACAA TCATTAGGGA TTACAGCAAC GAGTGGCAAA

GATGGCAAAA TTATCTTTAG AGACTTGGCG CCAGCTACCT ATTATTACAA AGAAATCAAA

GCACCAAAAT TACCAGATGG CGCAGATTAT ATTATTTATC CTGAATTAGT AAAAGTAGAA

ATTCGTGGTG ATTTCAAAGG TGATCCGGAG ATTTTCCAAT TAGGGGCCTT CGCCAATTTC

AAAGGACGCG CCGTCTTTAA GAAAATTGAT GCCAATGCGA ACCCACTTCC AGGAACGATT

TTTAAATTGT ATCGAATCGA AAACGGGGAA AAAATCTTTG AAAGAGAAGT AACTGCTGAA

AAAGATGGTT CATTGGCTAT GGAGGATTTA GGTGCTGGTA GCTATGAATT AGATGAACTG

GATGCAACGG ATOOCTATAT CGTCAATAAA CAACCCATTT ATTTTGTAGT GAAGAAGAAT

TCAAATCATA AACAACCACT AGATGAGTTA GAGTTTGTAA ATTATCAAGC AGAAGTAATG

GGACGTAAAG TCAACGAGCA AGGTCAAACC TTAGCGGGTG CAGTTTTTGC AATTTACAAT

GCCGATGAGC AGAATCAGCC CCAAGGTTCA CCCATAACAT TCTTGAATCG TGCAGGAGAA

AAAGTTTCTG AAATAACAAC GGATAAGACT GCCGAAATTT ACGCTAAAGG GCTAAATGAA

GGGCATTACG TTTTAGTGGA AACGAAAGCA CCAACAGGCT ATCTGTTAGA CACAACGCTA

CATCCATTTG ATGTAACCGC CCAATTAGGA AAAGAGCAGC CAATTGCTTT ACGCGATCTT

ATCAATTATC AAGGAACTGC TCAATTAACC AAAGAAAACG AAACAGGTGA AGCATTGGCA

GGTGCGGTGT TTAAGGTCAT TCATGAAACA GGGCAAACCG TAGATGGACA AACCAATCTG

ATCTCTGACA AGCAAGGCAA AGTCATTGCC AAAAACTTAG CACCGGGAAC GTATCGTTTT

GTGGAGACAC AAGCGCCAAC TAGCTATCTT CTTAATGAAA CGCCAAGCGC AAGCTTTACG

ATTGCCAAAG ACAACCAAGG CAAACCAGCC ACTGTGGTAC TTAAAGCACC TTTTATTAAT

TACCAAGGTG CTGCCAAGCT GGTGAAAATT GATCAGCAAA AGAATGCCTT AGCAGGTGCT

GAATTTAAAG TGACAGATGC AGAGACAGGG CAAACTGTCG CTCGTTCATT ACGTTCTGAC

AACCAAGGGT TAGTTCAAGT GAACCACTTA CAACCAGGAA AATATACCTT TGTGGAAACA

AAAGCACCGG ATOOTTACCA ACTGTCTAAC CAACCTGTCG CATTCACTAT TCCGGCAACA

GCGAAAGACA AACCTCAACT CGTGAATGCG GGCACGTTTG TTAACGAGAA ACAACCTGTA

TCCAAAAAAA CAAAACCAAA TCAGCCAACA ACGAAACAAG CAGCTAGAGA GACAGGTTGG

CTTGGTTTAC CGAAAACCAA CACACAAGTC AATTACTTCT TTCTCTTTAT CCGCCTCATG

TTCCTCGGTT TGGCAACTTG CCTCTTCTAT AAAAAGAGCA ACAAATAA

EF125-2 (SEQ ID NO:466)

MRKNGPMV NRWLYGLMCL LLVLNYGTPL MALAEEVNSD

GQLTLGEVKQ TSQQEMTLAL QCKAQPVTQE VVVHYSANVS IKAAHWAAPN NTRKIQVDDQ

KKQIQIELNQ QALADTLVLT LNPTATEDVT FSYGQQQRAL TLKTGTDPTE STAITSSPAA

SANEGSTEEA STNSSVPRSS EETVASTTKA IESKTTESTT VKPRVAGPTD ISDYFTGDET

TIIDNFEDPI YLNPDCTPAT PPYKEDVTIH WNFNWSIPED VREQMKAGDY FEFQLPGNLK

PNKPGSGDLV DAECNVYGTY TISEDGTVRF TFNERITSES DIHGDFSLDT HLNDSDGRGP

GDWVIDIPTQ EDLFPVVIPI VPDTEQQTDK QGHFDRTPNP SATTWTVDIN QAMKDQTNPT

VTETWPTGNT FKSVKVYELV HNLDGTIKEV GRELSPDEYT VDKNGNVTIK GDTNKAYRLE

YQTTIDEAVI PDGGGDVPFK NHATLTSDNN PNGLDAEATV TATYGKNLDK RNIDYDEANQ

SETWETNYNY GEQTIPKDQA VITDTMGDNL TFEPDSLHLY SVTFDDKGNE VVGAELVEGK

DYKVVINGDC SFAIDFLHDV TGAVKIDYKT KVDGIVEGDV AVNNRVDVGT GQHSEDDGTA

SQQNIIKNTC AVDYQNSTIG WTLAVNQNNY LMENAVITDT YEPVPGLTMV PNSLVVKDTT

TGAQLTLCKD FMVEITRNAD GETGFKVSFI GAYAKTSDAF HITYTTFFDV TELDANNPAL

DHYRNTAAID WTDEAGNNHH SEDSKPFKPL PAFDLNAQKS GVYNAVTKEI TWTIAVNLSN

NRLVDAFLTD PILTNQTYLA CSLKVYEGNT KPDGSVEKVK PTQPLTDITM EEPSEKNQNT

WRVDFPNDSR TYVIEFKTSV DEKVIECSAS YDNTASYTNQ GSSRDVTGKV SIQHGGESVK

KGGEYHKDDP DHVYWHVMIN GAQSVLDDVV ITDTPSPNQV LDPESLVIYG TNVTEDGTIT

PDKSVILEEG KDYTLEVTTD NETCQQKIVV KMAHIEAPYY MEYRSLVTSS AAGSTDTVSN

QVSITGNGSE VVHGDDNGDV VVDIDHSGCH ATGTKGKIQL KKTANDETTI LAGAHFQTWD

QAKTQVLREG TVDATGVITF GGLPQCQYIL VETKAPEGYT VSDELAKGRV ITIDEETSAE

GAQPTIIKND VNKVFLEKMD EKGKKLVNAR FKLEHAVTTP FTHWEEVPLA PDRTNANGQL

EVDSLKPGLY QFTEIEAPTG YLLDTTPKRF IVTQNTSGQI RDVHVKMLNY QGSAELIKKD

QAGNPLAGAE FSVLDTTGQA VREHLVSDAN GKVTVTDLAP GKYQFVETKA PACYLLNTEP

SAFTIAASDR GKPATVIATA NFVNYQCTAK LIKKDVNGHL LSGATFKVLD AKGETIQTGL

TTNNQGEIVA EHLAPGKYRF VETKAPTGYL LNTTPVFFEI AEKNACKPAV VVASDNFVSY

KGAFQIVKTN SADQPLAGAV FELYDHNKQS LGTTATSGKD OKITERDLAP GTYYYKETKA

PKLPDGADYI IYPELVKVEI RGDFKGDPEI FQLGAFANFK GEAVFKKIDA NANPLPGTIF

KLYRIENGEK IFEREVTAEK DGSLAMEDLG AGSYELDELD ATDGYIVNKQ PIYFVVKKNS

NDKQPLDELE FVNYQAEVMG RKVNEQGQTL AGAVFATYNA DEQNQPQGSP ITFLNPAGEK

VSEITTDKTC EIYAKGLNEG HYVLVETKAP TGYLLDTTLH PFDVTAQLGK EQPIALCDLI

NYQCTAQLTK ENETGEALAG AVFKVIDETG QTVDGQTNLM SDKQGKVTAK NLAPGTYRFV

ETQAPTSYLL NETPSASFTI AKDNQGKPAT VVLKAPFINY QGAAKLVKID QQKNALAGAE

FKVTDAETGQ TVARSLRSDN QGLVQVNHLQ PGKYTFVETK APDGYQLSKQ AVAFTIAATA

KDKPELVNAG TFVNEKQPVS KKTKPNQPTT KQAARETGWL GLPKTNTQVN YFFVFICLML

VGLASWLFYK KSKK

EF125-3 (SEQ ID NO:467)

TAACTTTG TTAACTATCA AGGCACGGCT AAATTAATCA AAAAAGATGT GAATGGACAC

TTATTAAGTG GTGCGACATT TAAAGTGCTT GATGCGAAGG CAGAAACGAT TCAAACAGGC

TTGACGACAA ATAATCAAGG GGAAATTGTT GCAGAGCACT TAGCCCCAGG AAAATATCGC

TTTGTAGAAA CCAAAGCGCC AACAGGCTAT TTATTAAATA CCACGCCAGT CCCATTTGAA

ATTGCTGAGA AAAATGCTGG TAAACCAGCG GTCGTGGTTG CTAGTGACAA CTTTGTGAGT

TACAAAGGGG CTTTCCAAAT CGTGAAAACG AATAGCGCAG ACCAACCATT AGCAGGTGCT

GTTTTTGAAT TATATGATCA CAATAAACAA TCATTAGGGA TTACAGCAAC GAGTGGCAAA

GATGGCAAAA TTATCTTTAG AGACTTCGCG CCAGGTACCT ATTATTACAA AGAAATCAAA

GCACCAAAAT TACCAGATGG CGCAGATTAT ATTATTTATC CTGAATTAGT AAAAGTAGAA

ATTCGTGGTG ATTTCAAAGG TGATCCGGAG ATTTTCCAAT TAGGGGCCTT CGCCAATTTC

AAAGGACGCG CCGTCTTTAA GAAAATTGAT GCCAATGCGA ACCCACTTCC AGGAACGATT

TTTAAATTGT ATCGAATCGA AAACGGGGAA AAAATCTTTG AAAGAGAAGT AACTGCTGAA

AAAGATGGTT CATTGGCTAT GGAGGATTTA GGTGCTGCTA GCTATGAATT AGATGAACTG

GATGCAACGG ATGGCTATAT CGTCAATAAA CAACCCATTT ATTTTGTAGT GAAGAAGAAT

TCAAATGATA AACAACCACT AGATGAGTTA GAGTTTGTAA ATTATCAAGC AGAAGTAATG

GGACGTAAAG TCAACGAGCA AGGTCAAACC TTAGCGCGTG CAGTTTTTGC AATTTACAAT

GCCGATGAGC AGAATCAGCC CCAAGGTTCA CCGATAACAT TCTTGAATCG TGCAGGAGAA

AAAGTTTCTG AAATAACAAC GGATAAGACT GGCGAAATTT ACCCTAAAGG GCTAAATGAA

GGGCATTACG TTTTAGTGGA AACGAAAGCA CCAACAGGCT ATCTGTTAGA CACAACGCTA

CATCCATTTG ATGTAACCGC CCAATTAGGA AAAGAGCAGC CAATTGCTTT AGGCGATCTT

ATCAATTATC AAGGAACTGC TCAATTAACC AAAGAAAACG AAACAGGTGA AGCATTGGCA

GGTGCGGTCT TTAACGTCAT TGATGAAACA GGGCAAACCG TAGATGGACA AACCAATCTG

ATGTCTCACA AGCAAGGCAA AGTCATTGCG AAAAACTTAG CACCGGGAAC GTATCGTTTT

GTGGAGACAC AAGCGCCAAC TAGCTATCTT CTTAATGAAA CGCCAAGCGC AACCTTTACG

ATTGCCAAAG ACAACCAAGG CAAACCAGCC ACTGTGGTAC TTAAAGCACC TTTTATTAAT

TACCAAGGTG CTGCCAAGCT GGTGAAAATT GATCAGCAAA AGAATGCCTT AGCAGGTGCT

GAATTTAAAG TGACAGATGC AGAGACAGGG CAAACTGTCG CTCGTTCATT ACGTTCTGAC

AACCAAGGGT TAGTTCAAGT GAACCACTTA CAACCAGGAA AATATACCTT TGTGGAAACA

AAAGCACCGG ATGGTTACCA ACTGTCTAAG CAAGCTGTCG CATTCACTAT TGCGGCAACA

GCGAAAGACA AACCTGAACT CGTGAATGCG GGCACGTTTG TTAACGAGAA ACAACCTGTA

TCCAAAAAAA CAAAACCAAA TCAGCCAACA ACGAAACAAG CAGCTAGAGA GACAGGTTGG

CTTGGT

EF125-4 (SEQ ID NO:468)

NFVNYQGTAK LIKKDXTNGHL LSGATFKVLD AKGETIQTGL

TTNNQGEIVA EHLAPGKYRF VETKAPTGYL LNTTPVPFEI AEKNAGKPAV VVASDNFVSY

KGAFQIVKTN SADQPLAGAV FELYDHNKQS LGITATSGKD GKIIFRDLAP GTYYYKEIKA

PKLPDGADYI IYPELVKVEI RGDFKGDPET FQLGAFANFK GRAVFKKIDA NANPLPGTIF

KLYRIENGEK IFEREVTAEK DGSLAMEDLG AGSYELDELD ATDGYTVNKQ PIYFVVKKNS

NDKQPLDELE FVNYQAEVMG RKVNEQGQTL AGAVEATYNA DEQNQPQGSP ITFLNRAGEK

VSEITTDKTG EIYAKGLNEG HYVLVETKAP TGYLLDTTLH PFDVTAQLGK EQPIALGDLI

NYQGTAQLTK ENETGEALAG AVFKVIDETG QTVDGQTNLM SDKQGKVIAK NLAPGTYRFV

ETQAPTSYLL NETPSASFTI AKDNQGKPAT VVLKAPFINY QCAAKLVKID QQKNALAGAE

FKVTDAETGQ TVARSLRSDN QGLVQVNHLQ PGKYTFVETK APDGYQLSKQ AVAFTTAATA

KDKPELVNAG TFVNEKQPVS KKTKPNQPTT KQAARETGWLG

EF126-1 (SEQ ID NO:469)

TAGCGAAAGA AAATAGCGAG GATTAAAATG TTTAAGAAAG CAACGAAATT ATTATCGACA

ATGGTGATTG TCGCTGGAAC AGTTGTGGGA AATTTCAGTC CCACATTGGC TTTAGCTGAA

GAAGCGGTTA AAGCAGGAGA TACAGAAGGA ATGACCAATA CGGTGAAAGT GAAAGACGAC

AGTCTGGCTG ATTGTAAACG GATATTGGAA GGACAAGCTA CTTTCCCAGT TCAAGCGGGT

GAAACGGAAC CAGTCGATTT AGTAGTTGTT GAAGATGCTA GTGGTAGTTT TTCAGATAAT

TTTCCACATG TAAGACAAGC GATTGATGAA GTGGTTCAAG GCTTATCTGA TCAAGACCGC

GTGATGCTGG CTTCATATCG CGGCGGAAAA CAATTTATGT TTCCTGATGG AAAGACAAAA

ATTAATTCAG CTGATTATGA TATGAATGTG CGCGTCAATA CGCAATTGAC TTATGATAAA

AGCCAATTTG TCTCTGGTTT TGGAGACGTT CGGACGTATG GTGGTACGCC AACCGCCCCA

GGATTGAAAC TCGCTTTAGA TACGTACAAT CAAACACACG GAGATTTAAC GAATCGAAAA

ACGTATTTCC TATTAGTGAC AGATGGGGTC GCTAATACAC GTTTAGATGG TTACTTGCAT

AAGACCAATA CCAATGATTC AATCAATGAA TATCCAGATC CAAGACATCC TCTTCAAGTC

TCAGTGGAAT ATAGTAATGA CTACCAAGGT GCAGCAGCAG AAGTTTTAGC GTTAAACCAA

GAAATTACTA ACCAAGGCTA TGAAATGATT AATGCGTATT GGGAAAGTGT TGAATCTTTA

AGTTCAGTGA ATTCATACTT TGATAAATAT AAAACAGAAG TGGGTCCTTT TGTAAAACAA

GAGTTGCAAC AAGGGTCTAG CACACCAGAA GATTTTATTA CAAGCCAATC TATTGATGAT

TTTACAACCC AATTAAAACA AATTGTCAAA GATCGTCTGG CGCAATCGAC ACCAGCAACA

GCTTCATTAA CGATTGCCAA TCAATTTGAT ATTCAATCTG CCACCGCTAC GGACCATGCT

GGAAATGATG TGCCTGTTCA AATTAACGGA CAAACCATTT CAGCAACTAG TACAGAAGGT

TACGTAGGAA ACATCACGAT TCACTACGAA CTCAAAGAAA ATACAGCGAT TGATGCAGCA

ACCCTTGTAA GTAGTGGGAC AATGAATCAA GGAACAATTG CTAAGGAATT TCCAGAAGCG

ACGATTCCTA AAAATGACAA TGCGCATGCG TGTCACGTGA CGCCAGAAGA TCCAACGATT

ACAAAAGATA TCGAAAATCA AGAACACTTA GATTTAACCA ATCGTGAAGA TAGTTTCGAT

TGGCATGTCA AAACAGCCTT TGGCAACGAA ACCAGTACTT GGACCCAAGC CAGCATGGTG

GATGACATTA ATAAAGTGCT AGATATCATT GATGTGAAAG TCACCGACCA AAATGGTAAA

GATGTTACAG CTAACGGCAC AGTAACACAA GAAAATAACA AAGTAACTTT TGAAATGAAC

AAACAAGCAG ACAGCTATGA CTATTTAAGT GGTCATACGT ATACAATGAC TATCACCACT

AAAATTAAAA CTGACGCAAC GGACGAAGAA TTAGCGCCTT ACATTGAACA AGGCGGGATT

CCCAACCAAG CCGACTTAAA CTTTGGCAAT GAAGGTGACG TGTTACATTC CAACAAACCA

ACCGTAACAC CACCGCCAGT TGATCCAAAT ATTCCTAAAG ACGTACAAGG ACAACAACAT

TTAGATTTAA CCAACCGCGA TCAAGAATTT AAATGGAACG TCAAAACAGC TTTCGGTAAC

GAAACAAGCA CTTGGACCCA AGCCAGCATG GTAGATGACA TTAATAAAGT GTTAGACATC

ACTGATGTAA AAGTCACAGA TGAAAATGGT AAAGATGTTA CAGCTAACGG CAAAGTAACA

CAAGAAAATA ACAAAGTAAC TTTTGAAATG AACAANCAAG CNGACAGCTA TGACTATTTA

AGTGGTCATA CGTACACAAT GACCATTACT ACTAAAATCA AAGCTAGCGC AACGGACGAA

GAATTAGCAC CTTATATTGA ACAAGGTGGC ATTCCCAACC AAGCCGACTT GAACTTTGGC

AACGAAGGTG ACGTGTTGCA TTCCAACAAA CCAACCGTAA CACCACCTGC ACCAACGCCA

GAAGATCCAA CGATTACAAA AGATATCGAA GGCCAAGAAC ATTTAGATTT AACCAACCGT

GACCAAGAAT TTAAATGGAA CGTCAAAACA GCTTTCGGTA ACGAAACAAG CACATGGACC

CAAGCCAGCA TGGTGGATGA CATTAATAAA GTGTTAGACA TCACAGACGT GAAAGTTNCT

GANGAAAATG GCAAAGATGT TACAGATAAT GGCATAGTAA CACAAGAAAA TAACAAAGTA

ACTTTTACTA TGAACAAAAA AGATGACAGC TACTCTTACT TAGCTGGTCA TACATACACA

ATGACTATTA CCACTAAAAT TAAAACTGAC GCAACGGATG AAGAATTAGC GCCTTATATT

GAACAAGGCG GGATTCCCAA CCAAGCCGAC TTAAACTTTG GCAACGAAGG TGACGTGTTG

CATTCCAACA AGCCAACCGT AACACCGCCT GCACCAACGC CAGAAGACCC AAAAAAACCT

GAACCTAAAC AACCGCTAAA ACCGAAAAAA CCGTTGACGC CTACAAATCA TCAAGCACCA

ACGAACCCAG TCAATTTTGG AAAATCAGCA AGTAAAGGAA TTCATTTACC AATGACTAAT

ACAACAGTAA ATCCACTTTA CATGATCGCA GGTTTAATTG TCCTTATAGT GGCTATTAGC

TTTGGCATAA CAAAAAATAA AANAAGAAAA AATTAG

EF126-2 (SEQ TD NO:470)

MF KKATKLLSTM VIVAGTVVGN FSPTLALAEE AVKAGDTEGM TNTVKVKDDS

LADCKRILEG QATFPVQAGE TEPVDLVVVE DASGSFSDNF PHVRQAIDEV VQGLSDQDRV

MLASYRGGKQ FMFPDGKTKI NSADYDMNVR VNTQLTYDKS QFVSGFGDVR TYGGTPTAPG

LKLALDTYNQ THGDLTNRKT YFLLVTDGVA NTRLDGYLHK TNTNDSINEY PDPRHPLQVS

VEYSNDYQGA AAEVLALNQE ITNQGYEMTN AYWESVESLS SVNSYFDKYK TEVGPFVKQE

LQQGSSTPED FITSQSIDDF TTQLKQJNKD RLAQSTPATA SLTIANQFDI QSATATDDAG

NDVPVQINGQ TISATSTEGY VGNITIHYEV KENTAIDAAT LVSSGTMNQG TIAKEEPEAT

IPKNDNAHAC DVTPEDPTIT KDIENQEHLD LTNREDSFDW HVKTAFGNET STWTQASMVD

DINKVLDIID VKVTDENGKD VTANGTVTQE NNKVTFEMNK QADSYDYLSG HTYTMTITTK

IKTDATDEEL APYIEQGGIP NQADLNFGNE GDVLHSNKPT VTPPPVDPNI AKDVEGQEHL

DLTNRDQEFK WNVKTAFGNE TSTWTQASMV DDINKVLDIT DVKVTDENCK DVTANGKVTQ

ENNKVTFEMN XQADSYDYLS GHTYTMTITT KIKASATDEE LAPYIEQGGI PNQADLNFGN

EGDVLHSNKP TVTPPAPTPE DPTITKDIEG QEHLDLTNRD QEFKWNVKTA FCNETSTWTQ

ASMVDDINKV LDITDVKVXX ENGKDVTDNG IVTQENNKVT FTMNKKDDSY SYLAGHTYTM

TITTKIKTDA TDEELAPYIE QGGIPNQADL NFGNEGDVLH SNKPTVTPPA PTPEDPKKPE

PKQPLKPKKP LTPTNHQAPT NPVNFGKSAS KGTHLPMTNT TVNPLYMIAG LIVLIVAISF

GITKNKKRKN

EF126-3 (SEQ ID NO:471)

TGAA

GAAGCGGTTA AAGCAGGAGA TACAGAAGGA ATGACCAATA CGGTGAAAGT GAAAGACGAC

AGTCTGCCTG ATTGTAAACG GATATTGGAA GGACAAGCTA CTTTCCCAGT TCAAGCGGGT

GAAACGCAAC CAGTCGATTT AGTAGTTGTT GAAGATGCTA GTGGTAGTTT TTCAGATAAT

TTTCCACATG TAAGACAAGC GATTGATGAA GTGGTTCAAG GCTTATCTGA TCAAGACCGC

GTGATGCTGG CTTCATATCG CGGCGGAAAA CAATTTATGT TTCCTGATGG AAAGACAAAA

ATTAATTCAG CTGATTATGA TATCAATGTG CGCGTCAATA CGCAATTGAC TTATGATAAA

AGCCAATTTG TCTCTGGTTT TGGAGACGTT CGGACGTATG GTGGTACGCC AACCGCCCCA

GGATTGAAAC TCGCTTTAGA TACGTACAAT CAAACACACG GAGATTTAAC GAATCGAAAA

ACGTATTTCC TATTAGTGAC AGATGGGGTC GCTAATACAC GTTTAGATGG TTACTTGCAT

AAGACCAATA CCAATGATTC AATCAATGAA TATCCAGATC CAAGACATCC TCTTCAAGTC

TCAGTGCAAT ATAGTAATGA CTACCAAGGT GCAGCAGCAG AAGTTTTAGC GTTAAACCAA

GAAATTACTA ACCAAGGCTA TGAAATGATT AATGCGTATT GGGAAAGTGT TGAATCTTTA

AGTTCAGTGA ATTCATACTT TGATAAATAT AAAACAGAAG TGGGTCCTTT TGTAAAACAA

GAGTTGCAAC AAGGGTCTAG CACACCAGAA GATTTTATTA CAAGCCAATC TATTGATGAT

TTTACAACCC AATTAAAACA AATTGTCAAA GATCGTCTGG CGCAATCGAC ACCAGCAACA

CCTTCATTAA CGATTGCCAA TCAATTTGAT ATTCAATCTG CGACCGCTAC GGACGATGCT

GGAAATGATG TGCCTGTTCA AATTAACGGA CAAACCATTT CAGCAACTAG TACAGAAGGT

TACGTAGGAA ACATCACCAT TCACTACGAA GTCAAAGAAA ATACAGCGAT TGAT

EF126-4 (SEQ ID NO:472)

EE AVKAGDTECM TNTVKVKDDS

LADCKRILEG QATFPVQAGE TEPVDLVVVE DASGSFSDNF PHVRQAIDEV VQGLSDQDRV

MLASYRGGKQ FMFPDGKTKI NSADYDHNVR VNTQLTYDKS QFVSGFGDVR TYGGTPTAPG

LKLALDTYNQ THGDLTNRKT YFLLVTDGVA NTRLDGYLHK TNTNDSINEY PDPRYPLQVS

VEYSNDYQGA AAEVLALNQE ITNQGYEMIN AYWESVESLS SVNSYFDKYK TEVGPFVKQE

LQQGSSTPED FITSQSIDDF TTQLKQIVKD RLAQSTPATA SLTIANQFDI QSATATDDAG

NDVPVQINGQ TISATSTEGY VGNITIHYEV KENTAID

EF127-1 (SEQ ID NO:473)

TAGCGAAAGA AAATAGGGAG GATTAAAATG TTTAAGAAAG CAACGAAATT ATTATCGACA

ATGGTGATTG TCGCTGGAAC AGTTGTGGGA AATTTCAGTC CCACATTGGC TTTAGCTGAA

GAAGCGGTTA AAGCAGGAGA TACAGAAGGA ATGACCAATA CGGTGAAAGT GAAAGACGAC

AGTCTGGCTG ATTGTAAACG GATATTGGAA GGACAAGCTA CTTTCCCAGT TCAAGCGGGT

GAAACGGAAC CAGTCGATTT AGTAGTTGTT GAAGATGCTA GTGGTAGTTT TTCAGATAAT

TTTCCACATC TAAGACAAGC GATTGATGAA GTGGTTCAAG GCTTATCTGA TCAAGACCGC

GTGATGCTGG CTTCATATCG CGGCGGAAAA CAATTTATGT TTCCTCATGG AAAGACAAAA

ATTAATTCAG CTGATTATGA TATGAATGTG CGCGTCAATA CGCAATTGAC TTATGATAAA

AGCCAATTTG TCTCTGGTTT TGGAGACGTT CGGACGTATG GTGGTACGCC AACCGCCCCA

GGATTGAAAC TCGCTTTAGA TACGTACAAT CAAACACACG GAGATTTAAC GAATCGAAAA

ACGTATTTCC TATTAGTGAC AGATGGGGTC GCTAATACAC GTTTAGATGG TTACTTGCAT

AAGACCAATA CCAATGATTC AATCAATGAA TATCCAGATC CAAGACATCC TCTTCAAGTC

TCAGTGGAAT ATAGTAATGA CTACCAAGGT GCAGCAGCAG AAGTTTTAGC GTTAAACCAA

GAAATTACTA ACCAAGGCTA TGAAATGATT AATGCGTATT GGGAAAGTGT TGAATCTTTA

AGTTCAGTGA ATTCATACTT TGATAAATAT AAAACAGAAG TGGGTCCTTT TGTAAAACAA

GAGTTGCAAC AAGGGTCTAG CACACCAGAA GATTTTATTA CAAGCCAATC TATTGATGAT

TTTACAACCC AATTAAAACA AATTCTCAAA GATCGTCTGG CGCAATCGAC ACCAGCAACA

GCTTCATTAA CGATTGCCAA TCAATTTGAT ATTCAATCTG CGACCGCTAC GGACGATGCT

GGAAATGATG TGCCTGTTCA AATTAACGGA CAAACCATTT CAGCAACTAG TACAGAAGGT

TACGTAGGAA ACATCACGAT TCACTACGAA GTCAAAGAAA ATACAGCGAT TGATGCAGCA

ACCCTTGTAA GTAGTGGGAC AATGAATCAA GGAACAATTG CTAAGCAATT TCCAGAAGCG

ACGATTCCTA AAAATGACAA TGCGCATGCG TGTGACGTGA CGCCAGAAGA TCCAACGATT

ACAAAAGATA TCGAAAATCA AGAACACTTA GATTTAACCA ATCGTGAAGA TAGTTTCGAT

TGGCATGTCA AAACAGCCTT TGGCAACGAA ACCAGTACTT GGACCCAAGC CAGCATGGTG

GATGACATTA ATAAAGTGCT AGATATCATT GATGTGAAAG TCACCGACGA AAATGGTAAA

GATGTTACAG CTAACGGCAC AGTAACACAA GAAAATAACA AAGTAACTTT TGAAATGAAC

AAACAAGCAG ACAGCTATGA CTATTTAAGT GGTCATACGT ATACAATGAC TATCACCACT

AAAATTAAAA CTGACGCAAC GGACGAAGAA TTAGCGCCTT ACATTGAACA AGGCGGGATT

CCCAACCAAG CCGACTTAAA CTTTGGCAAT GAAGGTGACG TGTTACATTC CAACAAACCA

ACCGTAACAC CACCGCCAGT TGATCCAAAT ATTGCTAAAG ACGTAGAAGG ACAAGAACAT

TTAGATTTAA CCAACCGCGA TCAAGAATTT AAATGGAACG TCAAAACAGC TTTCGGTAAC

GAAACAAGCA CTTGGACCCA AGCCAGCATG GTAGATGACA TTAATAAAGT GTTAGACATC

ACTGATGTAA AAGTCACAGA TGAAAATGGT AAAGATGTTA CAGCTAACCG CAAAGTAACA

CAAGAAAATA ACAAAGTAAC TTTTCAAATG AACAANCAAG CNGACAGCTA TGACTATTTA

AGTGGTCATA CGTACACAAT GACCATTACT ACTAAAATCA AAGCTAGCGC AACGGACGAA

GAATTAGCAC CTTATATTGA ACAAGGTGGC ATTCCCAACC AAGCCGACTT GAACTTTGGC

AACGAAGGTG ACGTGTTGCA TTCCAACAAA CCAACCGTAA CACCACCTGC ACCAACGCCA

GAAGATCCAA CGATTACAAA AGATATCGAA GGCCAAGAAC ATTTAGATTT AACCAACCGT

GACCAAGAAT TTAAATGGAA CGTCAAAACA GCTTTCGGTA ACGAAACAAG CACATGGACC

CAAGCCAGCA TGGTGGATGA CATTAATAAA GTGTTAGACA TCACAGACCT GAAAGTTNCT

GANGAAAATG GCAAAGATGT TACAGATAAT GGCATAGTAA CACAAGAAAA TAACAAAGTA

ACTTTTACTA TGAACAAAAA AGATGACAGC TACTCTTACT TAGCTGGTCA TACATACACA

ATGACTATTA CCACTAAAAT TAAAACTGAC GCAACGGATG AAGAATTAGC GCCTTATATT

GAACAAGGCG GGATTCCCAA CCAAGCCGAC TTAAACTTTG GCAACGAAGG TGACGTGTTG

CATTCCAACA AGCCAACCGT AACACCGCCT GCACCAACGC CAGAAGACCC AAAAAAACCT

GAACCTAAAC AACCGCTAAA ACCGAAAAAA CCGTTGACGC CTACAAATCA TCAAGCACCA

ACGAACCCAG TCAATTTTGG AAAATCAGCA AGTAAAGGAA TTCATTTACC AATGACTAAT

ACAACAGTAA ATCCACTTTA CATGATCGCA GGTTTAATTG TCCTTATAGT GGCTATTAGC

TTTGCCATAA CAAAAAATAA AAAAAGAAAA AATTAG

EF127-2 (SEQ ID NO:474)

ME KKATKLLSTM VIVAGTVVGN FSPTLALAEE AVKAGDTEGM TNTVKVKDDS

LADCKRILEG QATFPVQAGE TEPVDLVVVE DASGSFSDNF PHVRQAIDEV VQGLSDQDRV

MLASYRGGKQ FMFPDGKTKI NSADYDMNVR VNTQLTYDKS QFVSGFGDVR TYGGTPTAPG

LKLALDTYNQ THGDLTNRKT YFLLVTDGVA NTRLDGYLHK TNTNDSINEY PDPRHPLQVS

VEYSNDYQGA AAEVLALNQE ITNQGYEMIN AYWESVESLS SVNSYFDKYK TEVGPFVKQE

LQQGSSTPED FITSQSIDDF TTQLKQIVKD RLAQSTPATA SLTIANQFDI QSATATDDAG

NDVPVQINGQ TISATSTEGY VGNITIHYEV KENTAIDAAT LVSSGTHNQG TIAKEFPEAT

IPKNDNAHAC DVTPEDPTIT KDIENQEHLD LTNREDSFDW HVKTAFGNET STWTQASMVD

DINKVLDIID VKVTDENGKD VTANGTVTQE NNKVTFEMNK QADSYDYLSG HTYTMTITTK

IKTDATDEEL APYIEQGGIP NQADLNFGNE GDVLHSNKPT VTPPPVDPNI AKDVEGQEHL

DLTNRDQEFK WNVKTAFGNE TSTWTQASMV DDINKVLDIT DVKVTDENGK DVTANGKVTQ

ENNKVTFEMN XQADSYDYLS GHTYTMTITT KIKASATDEE LAPYIEQGGI PNQADLNFGN

EGDVLHSNKP TVTPPAPTPE DPTITKDIEG QEHLDLTNRD QEFKWNVKTA FGNETSTWTQ

ASMVDDINKV LDITDVKVXX ENGKDVTDNG IVTQENNKVT FTMNKKDDSY SYLAGHTYTM

TITTKIKTDA TDEELAPYIE QGGTPNQADL NFGNEGDVLH SNKPTVTPPA PTPEDPKKPE

PKQPLKPKKP LTPTNHQAPT NPVNFGKSAS KGIHLPMTNT TVNPLYMIAG LIVLIVAISF

GITKNKKRKN

EF127-3 (SEQ ID NO:475)

GAATCAA GGAACAATTG CTAAGGAATT TCCAGAAGCG

ACGATTCCTA AAAATGACAA TGCGCATGCG TGTGACGTGA CGCCAGAAGA TCCAACGATT

ACAAAAGATA TCGAAAATCA AGAACACTTA GATTTAACCA ATCGTGAAGA TAGTTTCGAT

TGGCATGTCA AAACAGCCTT TGGCAACGAA ACCAGTACTT GGACCCAAGC CAGCATGGTG

GATGACATTA ATAAAGTGCT AGATATCATT GATGTGAAAG TCACCGACGA AAATGGTAAA

GATGTTACAG CTAACGGCAC AGTAACACAA GAAAATAACA AAGTAACTTT TGAAATGAAC

AAACAAGCAG ACAGCTATGA CTATTTAAGT GGTCATACGT ATACAATGAC TATCACCACT

AAAATTAAAA CTGACGCAAC GGACGAAGAA TTAGCGCCTT ACATTGAACA AGGCGGGATT

CCCAACCAAG CCGACTTAAA CTTTGGCAAT CAAGGTGACC TGTTACATTC CAACAAACCA

ACCGTAACAC CACCGCCAGT TGATCCAAAT ATTGCTAAAG ACGTAGAAGG ACAAGAACAT

TTAGATTTAA CCAACCGCGA TCAAGAATTT AAATGGAACG TCAAAACAGC TTTCGGTAAC

GAAACAAGCA CTTGGACCCA AGCCAGCATG GTAGATGACA TTAAT

EF127-4 (SEQ ID NO:476)

NQG TIAKEF PEAT

IPKNDNAHAC DVTPEDPTIT KDIENQEHLD LTNREDSFDW HVKTAFGNET STWTQASMVD

DINKVLDIID VKVTDENGKD VTANGTVTQE NNKVTFENNK QADSYDYLSG HTYTMTITTK

IKTDATDEEL APYIEQGGIP NQADLNFGNE GDVLHSNKPT VTPPPVDPNI AKDVEGQEHL

DLTNRDQEFK WNVKTAFGNE TSTWTQASMV DDIN

EF12S-1 (SEQ ED NO:477)

TAGCGAAAGA AAATAGGGAG GATTAAAATG TTTAAGAAAG CAACGAAATT ATTATCGACA

ATGGTGATTG TCGCTGGAAC AGTTGTGGGA AATTTCAGTC CCACATTGGC TTTAGCTGAA

GAAGCGGTTA AAGCAGGAGA TACAGAAGGA ATGACCAATA CGGTGAAAGT GAAAGACGAC

AGTCTGGCTG ATTGTAAACG GATATTGGAA GGACAAGCTA CTTTCCCAGT TCAAGCGGGT

GAAACGGAAC CAGTCGATTT AGTACTTGTT GAAGATGCTA GTGGTAGTTT TTCAGATAAT

TTTCCACATG TAAGACAAGC GATTGATGAA GTGGTTCAAG GCTTATCTGA TCAAGACCGC

GTCATGCTGG CTTCATATCG CGGCGGAAAA CAATTTATGT TTCCTGATGG AAAGACAAAA

ATTAATTCAG CTGATTATGA TATGAATGTG CGCGTCAATA CGCAATTGAC TTATGATAAA

AGCCAATTTG TCTCTGGTTT TGGAGACGTT CGGACGTATG GTGGTACGCC AACCGCCCCA

GGATTGAAAC TCGCTTTAGA TACGTACAAT CAAACACACG GAGATTTAAC GAATCGAAAA

ACGTATTTCC TATTAGTGAC AGATGGGGTC GCTAATACAC GTTTAGATGG TTACTTGCAT

AAGACCAATA CCAATGATTC AATCAATGAA TATCCAGATC CAAGACATCC TCTTCAAGTC

TCAGTGGAAT ATAGTAATGA CTACCAAGGT GCAGCAGCAG AAGTTTTAGC GTTAAACCAA

GAAATTACTA ACCAAGGCTA TCAAATGATT AATGCGTATT GGGAAAGTGT TGAATCTTTA

AGTTCAGTGA ATTCATACTT TGATAAATAT AAAACAGAAG TGGGTCCTTT TGTAAAACAA

GAGTTGCAAC AAGGGTCTAG CACACCAGAA GATTTTATTA CAAGCCAATC TATTGATGAT

TTTACAACCC AATTAAAACA AATTGTCAAA GATCGTCTGG CGCAATCGAC ACCAGCAACA

GCTTCATTAA CGATTGCCAA TCAATTTGAT ATTCAATCTG CGACCGCTAC GGACGATGCT

GGAAATGATG TGCCTGTTCA AATTAACGGA CAAACCATTT CAGCAACTAG TACAGAAGGT

TACGTAGGAA ACATCACGAT TCACTACGAA GTCAAAGAAA ATACAGCGAT TGATGCAGCA

ACCCTTGTAA GTACTGGGAC AATGAATCAA GGAACAATTG CTAAGGAATT TCCAGAAGCG

ACGATTCCTA AAAATGACAA TGCGCATGCG TGTGACGTGA CGCCAGAAGA TCCAACGATT

ACAAAAGATA TCGAAAATCA AGAACACTTA GATTTAACCA ATCGTGAAGA TAGTTTCGAT

TGGCATGTCA AAACAGCCTT TGGCAACGAA ACCAGTACTT GGACCCAAGC CAGCATGGTG

GATGACATTA ATAAAGTGCT AGATATCATT GATGTGAAAG TCACCGACCA AAATGGTAAA

GATGTTACAG CTAACGGCAC AGTAACACAA GAAAATAACA AAGTAACTTT TGAAATGAAC

AAACAAGCAG ACAGCTATGA CTATTTAAGT GGTCATACGT ATACAATGAC TATCACCACT

AAAATTAAAA CTGACGCAAC GGACGAAGAA TTAGCGCCTT ACATTGAACA AGGCGGGATT

CCCAACCAAG CCGACTTAAA CTTTGGCAAT GAAGGTGACG TGTTACATTC CAACAAACCA

ACCGTAACAC CACCGCCAGT TGATCCAAAT ATTGCTAAAC ACGTAGAACG ACAAGAACAT

TTAGATTTAA CCAACCGCGA TCAAGAATTT AAATGGAACG TCAAAACAGC TTTCGGTAAC

GAAACAAGCA CTTGGACCCA AGCCAGCATG GTAGATGACA TTAATAAAGT GTTAGACATC

ACTGATGTAA AAGTCACAGA TGAAAATGGT AAAGATGTTA CAGCTAACGG CAAAGTAACA

CAAGAAAATA ACAAAGTAAC TTTTGAAATG AACAANCAAG CNGACAGCTA TGACTATTTA

AGTGGTCATA CGTACACAAT GACCATTACT ACTAAAATCA AAGCTAGCGC AACGGACGAA

GAATTAGCAC CTTATATTGA ACAAGGTGGC ATTCCCAACC AAGCCGACTT GAACTTTGGC

AACGAAGGTG ACGTGTTGCA TTCCAACAAA CCAACCGTAA CACCACCTGC ACCAACGCCA

GAAGATCCAA CGATTACAAA AGATATCGAA GGCCAAGAAC ATTTAGATTT AACCAACCGT

GACCAAGAAT TTAAATGGAA CGTCAAAACA GCTTTCGGTA ACGAAACAAG CACATGGACC

CAAGCCAGCA TGGTGGATGA CATTAATAAA GTGTTAGACA TCACAGACGT GAAAGTTNCT

GANGAAAATG GCAAAGATGT TACAGATAAT GGCATAGTAA CACAAGAAAA TAACAAAGTA

ACTTTTACTA TGAACAAAAA AGATGACAGC TACTCTTACT TAGCTGGTCA TACATACACA

ATGACTATTA CCACTAAAAT TAAAACTGAC GCAACGGATG AAGAATTAGC GCCTTATATT

GAACAAGGCG GGATTCCCAA CCAAGCCGAC TTAAACTTTG GCAACGAAGG TGACGTGTTG

CATTCCAACA AGCCAACCGT AACACCGCCT GCACCAACGC CAGAAGACCC AAAAAAACCT

GAACCTAAAC AACCGCTAAA ACCGAAAAAA CCGTTGACGC CTACAAATCA TCAAGCACCA

ACGAACCCAG TCAATTTTGG AAAATCAGCA AGTAAAGGAA TTCATTTACC AATGACTAAT

ACAACAGTAA ATCCACTTTA CATGATCGCA GGTTTAATTG TCCTTATAGT GGCTATTAGC

TTTGGCATAA CAAAAAATAA AAAAAGAAAA AATTAG

EF128-2 (SEQ ID NO:478)

MF KKATKLLSTM VIVAGTVVGN FSPTLALAEE AVKAGDTEGM TNTVKVKDDS

LADCKRILEG QATFPVQAGE TEPVDLVVVE DASGSFSDNF PHVRQAIDEV VQGLSDQDRV

MLASYRGGKQ FMFPDGKTKI NSADYDMNVR VNTQLTYDKS QFVSGFGDVR TYGGTPTAPG

LKLALDTYNQ THGDLTNRKT YFLLVTDGVA NTRLDGYLHK TNTNDSINEY PDPRHPLQVS

VEYSNDYQGA AAEVLALNQE ITNQGYEMTN AYWESVESLS SVNSYFDKYK TEVGPFVKQE

LQQGSSTPED FITSQSIDDF TTQLKQIVKD RLAQSTPATA SLTIANQFDI QSATATDDAG

NDVPVQINGQ TISATSTEGY VGNITIHYEV KENTAIDAAT LVSSGTMNQG TIAKEFPEAT

IPKNDNAHAC DVTPEDPTIT KDTENQEHLD LTNREDSFDW HVKTAFGNET STWTQASMVD

DINKVLDITD VKVTDENGKD VTANGTVTQE NNKVTFEMNK QADSYDYLSG HTYTMTITTK

IKTDATDEEL APYTEQGGIP NQADLNFGNE GDVLHSNKPT VTPPPVDPNI AKDVEGQEHL

DLTNRDQEFK WNVKTAFGNE TSTWTQASMV DDTNKVLDIT DVKVTDENGK DVTANGKVTQ

ENNKVTFEMN XQADSYDYLS GHTYTMTITT KIKASATDEE LAPYIEQGGI PNQADLNFGN

EGDVLHSNKP TVTPPAPTPE DPTITKDIEG QEHLDLTNRD QEFKWNVKTA FGNETSTWTQ

ASMVDDINKV LDITDVKVXX ENGKDVTDNG IVTQENNKVT FTHNKKDDSY SYLAGHTYTM

TITTKIKTDA TDEELAPYIE QGGIPNQADL NFGNEGDVLH SNKPTVTPPA PTPEDPKKPE

PKQPLKPKKP LTPTNHQAPT NPVNFGKSAS KGTHLPMTNT TVNPLYMIAG LIVLIVAISF

GITKNKKRKN

EF128-3 (SEQ ID NO:479)

AGA TCAAAATGGT AAAGATGTTA CAGCTAACGG CAAAGTAACA

CAAGAAAATA ACAAAGTAAC TTTTGAAATG AACAANCAAG CNGACAGCTA TGACTATTTA

AGTGGTCATA CGTACACAAT GACCATTACT ACTAAAATCA AAGCTAGCGC AACGGACGAA

GAATTAGCAC CTTATATTGA ACAAGGTGGC ATTCCCAACC AAGCCGACTT GAACTTTGGC

AACGAAGGTG ACGTGTTGCA TTCCAACAAA CCAACCGTAA CACCACCTGC ACCAACGCCA

GAAGATCCAA CGATTACAAA AGATATCGAA GGCCAAGAAC ATTTAGATTT AACCAACCGT

GACCAAGAAT TTAAATGGAA CGTCAAAACA GCTTTCGGTA ACGAAACAAG CACATGGACC

CAAGCCAGCA TGGTGGATGA CATTAATAAA GTGTTAGACA TCACAGACGT GAAAGTTNCT

GANGAAAATG GCAAAGATGT TACAGATAAT GGCATAGTAA CACAAGAAAA TAACAAAGTA

ACTTTTACTA TGAACAAAAA AGATGACAGC TACTCTTACT TAGCTGGTCA TACATACACA

ATGACTATTA CCACTAAAAT TAAAACTGAC GCAACGGATG AAGAATTAGC GCCTTATATT

GAACAAGGCG GGATTCCCAA CCAAGCCGAC TTAAACTTTG CCAACGAAGG TGACGTGTTG

CATTCCAACA AGCCAACCGT AACACCGCCT GCACCAACGC CAGAAGACCC AAAAAAACCT

GAACCTAAAC AACCGCTAAA ACCGAAAAAA CCGTTGACGC CTACAAATCA TCAAGCACCA

ACGAACCCAG TCAATTTTGG AAAATCAGCA AGTAAAGGAA TTCAT

EF128-4 (SEQ ID NO:480)

DENGK DVTANGKVTQ

ENNKVTFEMN XQADSYDYLS GHTYTMTITT KIKASATDEE LAPYIEQGGI PNQADLNFGN

EGDVLHSNKP TVTPPAPTPE DPTITKDIEG QEHLDLTNRD QEFKWNVKTA FGNETSTWTQ

ASMVDDJNKV LDITDVKVXX ENGKDVTDNG IVTQENNKVT FTMNKKDDSY SYLAGHTYTM

TITTKIKTDA TDEELAPYIE QGGIPNQADL NFGNEGDVLH SNKPTVTPPA PTPEDPKKPE

PKQPLKPKKP LTPTNHQAPT NPVNFGKSAS KGIH

EF129-1 (SEQ ID NO:481)

TGACAAGTGA AGAAACGTCT ATTTGCATCA GTATTACTAT GTTCATTAAC GCTATCAGCA

ATTGCTACCC CAAGCATCGC TTTGGCGGAC AATGTTGATA AAAAAATTGA AGAAAAAAAT

CAAGAAATTT CATCATTAAA AGCAAAACAA GGGGATTTAG CTTCACAAGT ATCTTCTTTA

GAAGCAGAAG TATCTTCAGT ATTTGATGAA AGCATGGCTT TACGTGAACA AAAGCAAACA

CTAAAAGCAA AATCAGAACA ATTACAACAA GAAATTACAA ACTTGAATCA ACGTATTGAA

AAACGTAACG AAGCAATCAA AAATCAAGCA CGTGATGTTC AAGTTAATGG ACAAAGCACA

ACAATGCTAG ATGCAGTTTT AGATGCGGAC TCAGTTGCAG ATGCAATCAG CCGTGTTCAA

GCTGTTTCAA CAATCGTAAG TGCCAACAAC GACTTAATGC AACAACAAAA AGAAGACAAA

CAAGCCGTTG TTGATAAAAA AGCTGAAAAC GAGAAAAAAG TGAAACAACT TGAAGCAACA

GAAGCTGAAT TAGAAACAAA ACGTCAAGAT TTACTTTCTA AACAATCTGA ATTAAACGTA

ATGAAAGCTT CATTAGCATT AGAACAATCA TCAGCTGAAA GTTCTAAAGC TGGCTTAGAA

AAACAAAAAG CAGCTGCTGA AGCAGAGCAA GCACGCTTAG CTGCTGAACA AAAAGCTGCA

GCTGAAAAAG CCAAACAAGC TGCTGCAAAA CCAGCTAAAG CTGAAGTGAA AGCAGAAGCA

CCAGTTGCCT CTTCATCAAC AACAGAAGCA CAAGCACCAG CAAGCTCAAG CTCAGCAACT

GAATCAAGCA CGCAACAAAC AACTGAAACA ACTACACCAA GTACAGATAA TAGTGCAACA

GAAAATACTG GCTCTTCTTC ATCAGAACAA CCAGTACAAC CTACAACACC AAGCGATAAT

GGAAATAATG GTGGCCAAAC TGGTGGTGGA ACAGTTACAC CAACACCAGA ACCAACACCA

GCGCCTTCTG CTGATCCAAC AATCAATGCA TTGAACGTTC TACGTCAATC ATTAGGTTTA

CGTCCAGTAG TATGGGATGC AGGTTTGGCA GCTTCTGCAA CTGCTCGTGC AGCACAAGTT

GAAGCAGGTG GCATTCCAAA TGATCACTGG TCTCGTGGAG ATGAAGTTAT CGCAATTATG

TGGGCGCCAG GTAACTCAGT AATCATGGCG TGGTACAATG AAACAAACAT GGTAACAGCT

TCAGGAAGCG GTCACCGTGA TTGGGAAATT AACCCAGGTA TTACGCGTGT CGGTTTTGGT

TACTCAGGTA GCACAATCGT AGGACACTCA GCCTAA

EF129-2 (SEQ ID NO:482)

VKKRLFASV LLCSLTLSAI ATPSIALADN VDKKTEEKNQ EISSLKAKQG DLASQVSSLE

AEVSSVFDES MALREQKQTL KAKSEQLQQE ITNLNQRTEK RNEAIKNQAR DVQVNGQSTT

MLDAVLDADS VADAISRVQA VSTTVSANND LMQQQKEDKQ AVVDKKAENE KKVKQLEATE

AELETKRQDL LSKQSELNVM KASLALEQSS AESSKAGLEK QKAAAEAEQA RLAAEQKAAA

EKAKQAAAKP AKAEVKAEAP VASSSTTEAQ APASSSSATE SSTQQTTETT TPSTDNSATE

NTGSSSSEQP VQPTTPSDNG NNGGQTGGGT VTPTPEPTPA PSADPTINAL NVLRQSLGLR

PVVWDACLAA SATARAAQVE AGGIPNDHWS RGDEVIAIMW APGNSVIMAW YNETNMVTAS

GSGHRDWEIN PGITRVGFGY SGSTIVGHSA

EF129-3 (SEQ ID NO:483)

GGAC AATGTTGATA AAAAAATTGA AGAAAAAAAT

CAAGAAATTT CATCATTAAA AGCAAAACAA GCGGATTTAG CTTCACAAGT ATCTTCTTTA

GAAGCAGAAG TATCTTCAGT ATTTGATGAA AGCATGGCTT TACGTGAACA AAAGCAAACA

CTAAAAGCAA AATCAGAACA ATTACAACAA GAAATTACAA ACTTGAATCA ACGTATTGAA

AAACGTAACG AAGCAATCAA AAATCAAGCA CGTGATGTTC AAGTTAATGG ACAAAGCACA

ACAATGCTAG ATGCAGTTTT AGATGCGGAC TCAGTTGCAG ATGCAATCAG CCGTGTTCAA

GCTGTTTCAA CAATCGTAAG TGCCAACAAC GACTTAATGC AACAACAAAA AGAAGACAAA

CAAGCCGTTG TTGATAAAAA AGCTGAAAAC GAGAAAAAAG TGAAACAACT TGAAGCAACA

GAAGCTGAAT TAGAAACAAA ACGTCAAGAT TTACTTTCTA AACAATCTGA ATTAAACGTA

ATGAAAGCTT CATTAGCATT AGAACAATCA TCAGCTGAAA GTTCTAAAGC TGGCTTAGAA

AAACAAAAAG CAGCTGCTGA AGCAGAGCAA GCACGCTTAG CTGCTGAACA AAAAGCTGCA

GCTGAAAAAG CCAAACAAGC TGCTGCAAAA CCAGCTAAAG CTGAAGTGAA AGCAGAAGCA

CCAGTTGCCT CTTCATCAAC AACAGAAGCA CAAGCACCAG CAAGCTCAAG CTCAGCAACT

GAATCAAGCA CGCAACAAAC AACTGAAACA ACTACACCAA GTACAGATAA TAGTGCAACA

GAAAATACTG GCTCTTCTTC ATCAGAACAA CCAGTACAAC CTACAACACC AAGCGATAAT

GGAAATAATG GTGGCCAAAC TGGTGGTGGA ACAGTTACAC CAACACCAGA ACCAACACCA

GCGCCTTCTG CTGATCCAAC AATCAATGCA TTGAACGTTC TACGTCAATC ATTAGGTTTA

CGTCCAGTAG TATGGGATGC AGGTTTGGCA GCTTCTGCAA CTGCTCGTGC AGCACAAGTT

GAAGCAGGTG GCATTCCAAA TGATCACTGG TCTCGTGGAG ATGAAGTTAT CGCAATTATG

TGGGCGCCAG GTAACTCAGT AATCATGGCG TGGTACAATG AAACAAACAT GGTAACAGCT

TCACGAAGCG GTCACCGTGA TTGGGAAATT AACCCAGGTA TTACGCGTGT CGGTTTTGGT

TACTCAGGTA GCACAATCGT AGGACACTCA GCC

EF129-4 (SEQ ID NO:484)

DN VDKKIEEKNQ EISSLKAKQG DLASQVSSLE

AEVSSVFDES MALREQKQTL KAKSEQLQQE ITNLNQRIEK RNEAIKNQAR DVQVNGQSTT

MLDAVLDADS VADAISRVQA VSTIVSANND LMQQQKEDKQ AVVDKKAENE KKVKQLEATE

AELETKRQDL LSKQSELNVM KASLALEQSS AESSKAGLEK QKAAAEAEQA RLAAEQKAAA

EKAKQAAAKP AKAEVKAEAP VASSSTTEAQ APASSSSATE SSTQQTTETT TPSTDNSATE

NTGSSSSEQP VQPTTPSDNG NNGGQTGGGT VTPTPEPTPA PSADPTINAL NVLRQSLGLR

PVVWDAGLAA SATARAAQVE AGGIPNDHWS RGDEVIAIMW APGNSVIMAW YNETNMVTAS

GSGHEDWEIN PGITRVGFGY SGSTIVGHSA

EF130-1 (SEQ ID NO:485)

TGATACATTA AAAGGAGGGA AAATATGCGC CCAAAAGAGA AAAAAAGAGG AAAAAATTGG

TTAATCAACA GTTTATTAGT TTTACTATTT ATCATTGGCT TAGCCTTAAT TTTTAACAAT

CACATACGTA GTTGGGTGGT TCAACAAAAT AGCCGCTCGT ACGCCGTTAG CAAGTTCAAA

CCAGCTGATG TCAAGAAAAA TATGGCTCGT GAAACAACGT TTGACTTTGA TTCAGTTGAG

TCCTTGAGCA CAGAAGCGGT GATGAAAGCC CAATTTGAAA ACAAAAACTT ACCTGTGATT

GGTGCCATTG CGATACCAAG TGTCGAAATT AATTTGCCCA TTTTTAAAGG ATTGTCCAAT

GTCGCTTTAT TAACTGGTGC CGGGACCATG AAAGAAGATC AAGTCATGGG GAAAAACAAT

TATGCCTTCG CTAGTCATCG AACGGAAGAT GGCGTTTCCT TATTTTCACC TTTAGAAAGA

ACCAAAAAAG ACGAACTCAT TTATATCACT GATTTATCTA CTGTTTATAC ATACAAAATA

ACTTCTGTAG AAAAAATCGA ACCAACCCGT GTTGAGTTAA TTGATGACGT TCCTGGTCAA

AATATGATTA CCTTAATTAC CTGTGGCGAT TTACAAGCAA CGACGCGAAT TGCTGTTCAA

GGAACATTAG CAGCAACGAC GCCTATTAAA GACCCCAACG ACGATATGTT GAAGGCTTTC

CAATTGCAGC AAAAAACTTT ACCCGATTGG GTGGCTTAA

EF130-2 (SEQ ID NO:486)

YIKRRENMRP KEKKRGKNWL INSLLVLLFT ICLALIFNNQ IRSWVVQQNS RSYAVSKLKP

ADVKKNMARE TTFDFDSVES LSTEAVMKAQ FENKNLPVIG AIAIPSVEIN LPIFKGLSNV

ALLTGAGTMK EDQVMGKNNY ALASHRTEDG VSLFSPLERT KKDELIYTTD LSTVYTYKIT

SVEKIEPTRV ELIDDVPGQN MITLITCGDL QATTRIAVQG TLAATTPIKD ANDDMLKAFQ

LEQKTLADWV A

EF130-3 (SEQ ID NO:487)

CGTTAG CAAGTTGAAA

CCAGCTGATG TGAAGAAAAA TATGGCTCGT GAAACAACGT TTGACTTTGA TTCAGTTGAG

TCCTTGAGCA CAGAAGCGGT GATGAAAGCC CAATTTGAAA ACAAAAACTT ACCTGTGATT

GGTGCCATTG CGATACCAAG TGTCGAAATT AATTTGCCCA TTTTTAAAGG ATTGTCCAAT

GTCGCTTTAT TAACTGGTGC CGGGACCATG AAAGAAGATC AAGTCATGGG GAAAAACAAT

TATGCCTTGG CTAGTCATCG AACGGAAGAT GGCGTTTCCT TATTTTCACC TTTAGAAAGA

ACCAAAAAAG ACGAACTCAT TTATATCACT GATTTATCTA CTGTTTATAC ATACAAAATA

ACTTCTGTAG AAAAAATCGA ACCAACCCGT GTTGAGTTAA TTGATGACGT TCCTGGTCAA

AATATGATTA CCTTAATTAC CTGTGGCGAT TTACAAGCAA CGACGCGAAT TGCTGTTCAA

GGAACATTAG CAGCAACGAC GCCTATTAAA GACGCCAACG ACGATATGTT GAAGGCTTTC

CAATTGGAGC AAAAAACTTT AGCCGATTGG GTGGCT

EF130-4 (SEQ ID NO:488)

VSKLKP

ADVKKNMARE TTFDFDSVES LSTEAVMKAQ FENKNLPVIG AIAIPSVEIN LPILFKGLSNV

ALLTGAGTMK EDQVMGKNNY ALASHRTEDG VSLFSPLERT KKDELIYTTD LSTVYTYKIT

SVEKIEPTRV ELIDDVPGQN MITLITCGDL QATTRIAVQG TLAATTPIKD ANDDMLKAFQ

LEQKTLADWV A

EF131-1 (SEQ ID NO:489)

TAGGCGGAGG TAAGCGGTAT GCGTAAACGA CATGCAAAGA AAAGACATGG AGGAGTGAAT

TGGCTTTTTA TAGTATGTTT GTTGGTGGTG ATTGGTGGTA GTGGTTATTT AATAAAAACG

TTCTTTTTCA OTAGAGATTO ACAAGTTAGT CAAGAATCGA AAGTGGTCTT GGAACAAGAT

CGCCGAAGTG ATAATTATGC GAATTTAACG AAAGAAATAG TTGCACCAGA TAGTGGCGAA

CTTGATCAAA AAATTCAAGA AACAAATTAT ATTGGTTCGG CTTTGATCAT TAAAGATGAT

CAGGTTTTAG TAAATAAAGG ATATGGCTTT GCCAATTTTG AAAAGCAACA AGCCAACACG

CCAAACACAA GGTTTCAGAT TGGCTCAATT CAAAAATCTT TTACCACAAC CTTGATCTTA

AAAGCAATTG AAGAAGGTAA ACTTACATTA GATACAAAAC TCGCTACGTT TTATCCGCAA

ATTCAAGGTG CTGAGGATAT TACGATTAGC GATATGTTGA ATATGACAAG TGGTTTAAAG

TTATCAGCAA TGCCTAATAA TATCGTTACC GATGAAGAAA TTATTCAATT TGTTAAACAA

AATACCATTC AAGTCAATAA AGGAAAATAC AATTATTCCC CAGTAAATTT TGTCCTTTTA

GCAGGAATGT TAGAGAAAAT GTATCAACGT ACCTATCAAG AATTATTTAA TAATCTTTAT

CACAAAACGG CTGGTTTAAA GAATTTTGGC TTCTATGAAA CCTTATTGGA ACAGCCCAAT

AATTCAACAA GTTATAAATG GACAGAAGAT AATTCATATA ACCAAGTGCT CTCAATTCCT

GCAGCTAGTT TTCCCCATGA ATTTGGGACT GGTAATGTGG ATATOAGGAC ACGTGATTTC

TATTGGTACT TACATCAATT AACGAGTGGA CATTTAGTTT CCACCGCACT TTTGCAAAAA

TTATCCACGT CTTCTCAGCA AAGCTCTTAT CATGGCCGCA TCTATGTTCA TGATAATTAT

TTACGTTTAC ACGGCGTTGA AGCGGGTCAA CAAGCCCTGG TTTTATTTTC AAAAGATATG

AAGACAGGGG TCATATTGCT AACTAACTGT GTGAATCCAG CCAAATACAA AGAATTAATT

GGTTCGTTGT TCCATGATGT AACCAATTTA ACTGTTAAAT TTTAA

EF131-2 (SEQ ID NO:490)

MRKRH AKKRHGGVNW LFILVCLLVVI GGSGYLIKTF FFTRDSQVSQ ESKVVLEEDR

RSDNYANLTK EIVAPDSGEL DQKIQETNYI GSALIIKDDQ VLVNKGYGFA NFEKQQANTP

NTRFQIGSIQ KSFTTTLILK ATEEGKLTLD TKLATFYPQI QGAEDITISD MLNNTSGLKL

SAMPNNIVTD EEIIQFVKQN TIQVNKGKYN YSPVNFVLLA GMLEKMYQRT YQELFNNLYH

KTAGLKNFGF YETLLEQPNN STSYKWTEDN SYNQVLSIPA ASFAHEFGTG NVDNTTGDLY

WYLHQLTSGH LVSTALLQKL WTSSQQSSYH GGIYVHDNYL RLHGVEACQQ ALVLFSKDMK

TGVILLTNCV NPAKYKELIG SLFHDVTNLT VKF

EF131-3 (SEQ ID NO:491)

TTT AATAAAAACG

TTCTTTTTCA CTAGAGATTC ACAAGTTACT CAAGAATCGA AACTGGTCTT GGAACAAGAT

CGCCGAAGTG ATAATTATGC GAATTTAACC AAAGAAATAC TTGCACCAGA TAGTGGCGAA

CTTGATCAAA AAATTCAAGA AACAAATTAT ATTCGTTCGG CTTTGATCAT TAAAGATGAT

CAGGTTTTAG TAAATAAAGG ATATGGCTTT GCCAATTTTG AAAAGCAACA AGCCAACACG

CCAAACACAA GGTTTCAGAT TGGCTCAATT CAAAAATCTT TTACCACAAC CTTGATCTTA

AAAGCAATTG AAGAAGGTAA ACTTACATTA GATACAAAAC TCGCTACGTT TTATCCGCAA

ATTCAAGGTG CTGAGGATAT TACGATTAGC GATATGTTGA ATATGACAAG TGGTTTAAAG

TTATCAGCAA TCCCTAATAA TATCGTTACC GATGAAGAAA TTATTCAATT TGTTAAACAA

AATACCATTC AAGTCAATAA AGGAAAATAC AATTATTCCC CAGTAAATTT TCTCCTTTTA

GCAGGAATCT TAGAGAAAAT GTATCAACGT ACCTATCAAG AATTATTTAA TAATCTTTAT

CACAAAACGG CTGGTTTAAA GAATTTTGGC TTCTATGAAA CCTTATTGGA ACAGCCCAAT

AATTCAACAA GTTATAAATG GACAGAAGAT AATTCATATA ACCAAGTGCT CTCAATTCCT

GCAGCTAGTT TTGCCCATGA ATTTGGGACT GGTAATGTGG ATATGACGAC AGGTGATTTG

TATTGGTACT TACATCAATT AACGAGTCGA CATTTACTTT CCACCGCACT TTTCCAAAAA

TTATGGACGT CTTCTCAGCA AAGCTCTTAT CATGGCGGCA TCTATGTTCA TGATAATTAT

TTACCTTTAC ACGGCGTTGA AGCGGGTCAA CAAGCCCTGG TTTTATTTTC AAAAGATATG

AAGACAGGCG TCATATTGCT AACTAACTGT CTGAATCCAG CGAAATACAA AGAATTAATT

GGTTCGTTGT TCCATGATGT AACCAATTTA ACTGTTAAAT TT

EF131-4 (SEQ ID NO:492)

LIKTF FFTRDSQVSQ ESKVVLEEDR

RSDNYANLTK EIVAPDSGEL DQKIQETNYI GSALIIKDDQ VLVNKGYGFA NFEKQQANTP

NTRFQTGSIQ KSFTTTLILK AIEEGKLTLD TKLATFYPQI QGAEDITISD MLNMTSGLKL

SAMPNNIVTD EEIIQFVKQN TIQVNKGKYN YSPVNFVLLA GMLEKMYQRT YQELFNNLYH

KTAGLKNFGF YETLLEQPNN STSYKWTEDN SYNQVLSIPA ASFAHEFGTG NVDMTTGDLY

WYLHQLTSGH LVSTALLQKL WTSSQQSSYH GGIYVHDNYL RLHGVEAGQQ ALVLFSKDMK

TGVILLTNCV NPAKYKELIG SLFHDVTNLT VKF

EF132-1 (SEQ ID NO:493)

TAGTTTTCTAATCTCACCAAAACAAAAATTTTTAAGAAAGAAGGAGAGATCGTTATGATGAGAAAATGGAAAGTAGTA

GTGGGAAGTCTCCGAATCTTGATTGCTCTTTTTATATTCGGGGCATGTTCAACAAATAGTAAAGACAAAGATACAGTG

GCTTCGAACGAAAAATTAAAGGTAGTAGTTACTAATTCGATTTTAGCAGATATTACTGAAAATATAGCAAAAGATAAA

ATTGATTTACACAGTATCGTACCTATTGGGAAAGATCCCCACGAATATGAACCtTTGCCTGAAGATGTTCAAAAAACT

TCAAAAGCAGATTTGATTTTTTATAACGGTGTTAACTTGGAmACTGGAGGAAATGCTTGGTTTACAAAATTAGThAAA

mATGCCAACAAAGAGGAAAACAAAGACTATTTTGCAGCAAGTGATGGCATAGATGTTATTTACTTAGAGGGTCAGAGT

GAGAAAGGGAAGGAAGATCCCCATGCTTGGTTAAATTTAGAAAACGGTATTATTTACGCTAAAAATATTGAAAAATGG

TTAGCGGAAAAAGATCCTGATAATAAAAAATTCTATAAAGAAAATCTAGATAAGTATATTGAAAAGTTGGATTCTCTA

GACAAAGAAGCTAAATCTAAATTTGCTTCAATTCCGAATGATAAAAAAATGATTCTTACAAGTGAAGGATGCTTtAAA

TATTTCTCGAAAGCGTATAATGTGCCTTCTGCTTACATTTGGGAAAtCAACACTGAAGAAGAAGGAACACCAGATCAA

ATAAAACACTTAGTTGAAAAATTACGCACAACAAAAGTTCCCTCCTTATTCGTAGAAAGTAGTGTGGACGATAGACCG

ATGAAAACAGTATCAAAAGATACCAATATTCCTATCTATTCAACGATTTTTACTGATTCAATTGCAGAAAAAGGACAA

GATGGTGATAGTTACTATGCGATGATGAAATGGAACCTGGATAAAATTGCTGAAGGCCTTTCGAAATAA

EF132-2 (SEQ ID NO:494)

MNRKWKVVVGSLGMLIALFIFGACSTNSKDKDTVASNEKLKVVVTNSTLADITENIAKDKIDLHSIVPIGKDPHEYEP

LPEDVQKTSKADLIFYNGVNLXTGGNAWFTKLVKXANKEENKDYFAASDGIDVIYLEGQSEKGKEDPHAWLNLENGII

YAKNIEKWLAEKDPDNKKFYKENLDKYIEKLDSLDKEAKSKFASIPNIDKKMVTSEGCFKYFSKAYNVPSAYIWEINT

EEEGTPDQIKHLVEKLRTTKVPSLFVESSVDDRPMKTVSKDTNIPIYSTIFTDSIAEKGQDGDSYYAMMKWNLDKIAE

GLSK.

EF132-3 (SEQ ID NO:495)

ATGTTCAACAAATAGTAAAGACAAAGATACAGTGGCTTCGAACGAAAAATTAAACGTAGTAGTTACTAATTCGATTTT

AGCAGATATTACTGAAAATATAGCAAAAGATAAAATTGATTTACACAGTATCGTACCTATTCCGAAAGATCCCCACGA

ATATGAACCtTTGCCTGAAGATGTTCAAAAAACTTCAAAAGCAGATTTGATTTTTTATAACGGTGTTAACTTGGAmAC

TGGAGGAAATGCTTGGTTTACAAAATTAGTAAAAmATGCGAACAAAGAGGAAAACAAAGACTATTTTGCAGCAAGTGA

TGGCATAGATGTTATTTACTTAGAGGGTCAGAGTGAGAAAGGGAAGGAACATCCCCATGCTTGGTTAAATTTAGAAAA

CGGTATTATTTACGCTAAAAATATTGAAAAATGGTTAGCGGAAAAAGATCCTGATAATAAAAAATTCTATAAAGAAAA

TCTAGATAAGTATATTGAAAAGTTGGATTCTCTAGACAAAGAAGCTAAATCTAAATTTCCTTCAATTCCGAATCATAA

AAAAATGATTGTTACAAGTGAAGGATGCTTtAAATATTTCTCGAAAGCGTATAATGTGCCTTCTGCTTACATTTGGGA

AAtCAACACTGAAGAAGAAGGAACACCAGATCAAATAAAACACTTAGTTGAAAAATTACGCACAACAAAAGTTCCCTC

CTTATTCGTAGAAAGTAGTGTGGACGATAGACCGATGAAAACAGTATCAAAAGATACCAATATTCCTATCTATTCAAC

GATTTTTACTGATTCAATTGCAGAAAAAGGACAAGATGGTGATAGTTACTATCCGATGATGAAATGGAACCTGGATAA

AATTGCTGAAGGCCTTTCGAAA

EF132-4 (SEQ ID NO:496)

CSTNSKDKDTVASNEKLKVVVTNSILADITENIAKDKIDLHSIVPIGKDPHEYEPLPEDVQKTSKADLIFYNGVNLXT

GGNAWFTKLVKXANKEENKDYFAASDGIDVIYLEGQSEKGKEDPHAWLNLENGIIYAKNIEKWLAEKDPDNKKFYKEN

LDKYIEKLDSLDKEAKSKFASEPNDKKNIVTSEGCFKYFSKAYNVPSAYIWEINTEEEGTPDQIKHLVEKLRTTKVPS

LFVESSVDDRPMKTVSKDTNIPIYSTIFTDSIAEKGQDGDSYYANINKWNLDKTAEGLSK

TABLE 2


Closest matching sequences between the polypeptides of the present invention and sequences in GenBank and Derwent databases.

	GenBank		BLAST	BLAST
Query	Access. No.	GenBank Gene Description	Score	P-Value

EF002-2	gi\|2338759	(AF018073) periplasmic sorbitol-binding protein; SmoE	113	3.60E-18
		[Rhodobacter
EF003-2	gi\|1552773	hypothetical [Escherichia coli] >gnl\|PID\|d1012634 hypothetical	278	1.20E-53
		29.4
EF003-2	gi\|2196996	lipoprotein homolog [Treponema pallidum] >gi\|2108234 29K	309	3.30E-44
		protein
EF003-2	gi\|146649	lipoprotein-28 precursor [Escherichia coli] >gi\|290510	263	9.20E-40
EF003-2	gi\|48838	28 3kDa membrane protein [Haemophilus influenzae]	197	2.10E-39
EF003-2	gi\|1573614	28 kDa membrane protein (hlpA) [Haemophilus influenzae]	197	7.80E-39
EF003-2	gi\|2314748	(AE000654) outer membrane protein [Helicobacter pylori]	263	4.60E-37
EF003-2	gi\|349530	lipoprotein [Pasteurella haemolytica] >gi\|150508 lipoprotein	189	4.10E-29
EF003-2	gnl\|PID\|e118435	similar to hypothetical proteins [Bacillus subtilis]	158	2.70E-26
EF003-2	gi\|349532	lipoprotein [Pasteurella haemolytica] >pir\|JN0753\|JN0753 outer	200	1.20E-25
EF003-2	gi\|1336657	lipoprotein [Bacillus subtilis]	182	2.70E-25
EF003-2	gnl\|PID\|e233873	hypothetical protein [Bacillus subtilis] >gnl\|PID\|e1182900	186	1.30E-23
EF003-2	gi\|294071	lipoprotein 3 [Pasteurella haemolytica]	199	6.60E-23
EF003-2	gi\|349531	lipoprotein [Pasteurella haemolytica] >pir\|JN07521JN0752 outer	198	1.30E-20
EF003-2	gi\|294070	lipoprotein 2 [Pasteurella haemolytica]	198	1.80E-20
EF005-2	gi\|537235	Kenn Rudd identifies as gpmB [Escherichia coli] >gi\|1790856	127	6.20E-12
EF006-2	gi\|552773	hypothetical [Escherichia coli] >gnl\|PID\|d1012634 hypothetical	255	1.40E-60
		29.4
EF006-2	gi\|349532	lipoprotein [Pasteurella haemolytica] >pir\|JN0753\|JN0753 outer	221	6.40E-49
EF006-2	gi\|2314748	(AE000654) outer membrane protein [Helicobacter pylori]	283	2.70E-48
EF006-2	gi\|2196996	lipoprotein homolog [Treponema pallidum] >gi\|2108234 29K	267	4.40E-47
		protein
EF006-2	gnl\|PID\|e118435	similar to hypothetical proteins [Bacillus subtilis]	359	1.80E-44
EF006-2	gi\|349531	lipoprotein [Pasteurella haemolytica] >pin\|JN0752\|JN0752 outer	218	3.80E-41
EF006-2	gi\|294071	lipoprotein 3 [Pasteurella haemolytica]	220	2.30E-38
EF006-2	gi\|146649	lipoprotein-28 precursor [Escherichia coli] >gi\|290510	193	2.60E-38
EF006-2	gi\|294070	lipoprotein 2 [Pasteurella haemolytica]	218	1.20E-36
EF006-2	gi\|148838	28 3kDa membrane protein [Haemophilus influenzae]	112	8.50E-34
EF006-2	gi\|1573614	28 kDa membrane protein (hlpA) [Haemophilus influenzae]	112	1.50E-33
EF006-2	gi\|349530	lipoprotein [Pasteurella haemolytica] >gi\|150508 lipoprotein	114	4.30E-29
EF006-2	gi\|294069	lipoprotein 1 [Pasteurella haemolytica]	114	1.30E-27
EF006-2	gi\|1336657	lipoprotein [Bacillus subtilis]	202	2.10E-26
EF006-2	gnl\|PID\|e233873	hypothetical protein [Bacillus subtilis] >gnl\|PID\|e1182900	200	6.50E-25
EF008-2	gi\|493017	endocarditis specific antigen [Enterococcus faecalis]	1590	2.70E-211
EF008-2	gi\|393269	adhesion protein [Streptococcus pneumoniae]	986	1.80E-129
EF008-2	gi\|153834	adhesin specific for salivary pellicle of dental surfaces	973	1.00E-127
EF008-2	gi\|1575030	surface adhesin A precursor [Streptococcus pneumoniae]	934	2.90E-126
EF008-2	gi\|153826	adhesin B [Streptococcus sanguis] >pir\|A43583\|A43583 adhesin	916	3.90E-126
		B
EF008-2	gi\|1184932	ScbA [Streptococcus crista]	915	3.40E-125
EF008-2	gi\|1117994	surface antigen A variant precursor [Streptococcus pneumoniae]	917	5.60E-124
EF008-2	gi\|310633	adhesin [Streptococcus gordonii]	891	6.00E-122
EF008-2	gnl\|PID\|e255529	lipoprotein [Staphylococcus epidermidis]	476	1.20E-99
EF008-2	gi\|1573330	adhesin B precursor (fimA) [Haemophilus influenzae]	380	1.60E-68
EF008-2	gi\|1245464	YfeA [Yersinia pestis] >gi\|1245464 YfeA [Yersinia pestis]	355	1.20E-64
EF008-2	gi\|755075	periplasmic-binding protein [Synechocystis sp.]	321	1.70E-62
		>gnl\|PID\|d1018652 Mn
EF008-2	gi\|1335912	EwlA [Erysipelothrix rhusiopathiae]	232	4.40E-42
EF008-2	gnl\|PID\|e118595	similar to ABC transporter (membrane protein) [Bacillus	204	4.10E-38
EF008-2	gi\|1777933	TroA [Treponema pallidum]	181	2.40E-35
EF009-2	gi\|349531	lipoprotein [Pasteurella haemolytica] >pir\|JN0752\|JN0752 outer	391	4.00E-64
EF009-2	gi\|1552773	hypothetical [Escherichia coli] >gnl\|PID\|d1012634 hypothetical	359	1.90E-63
		29.4
EF009-2	gi\|294070	lipoprotein 2 [Pasteurella haemolytica]	391	6.40E-63
EF009-2	gi\|349532	lipoprotein [Pasteurella haemolytica] >pir\|JN0753\|JN0753 outer	386	1.10E-61
EF009-2	gi\|148838	28 3kDa membrane protein [Haemophilus influenzae]	286	5.60E-60
EF009-2	gi\|1573614	28 kDa membrane protein (hlpA) [Haemophilus influenzae]	286	7.60E-60
EF009-2	gi\|294069	lipoprotein 1 [Pasteurella haemolytica]	122	4.70E-59
EF009-2	gi\|146649	lipoprotein-28 precursor [Escherichia coli] >gi\|290510	326	2.20E-58
EF009-2	gi\|349530	lipoprotein [Pasteurella haemolytica] >gi\|150508 lipoprotein	239	7.80E-57
EF009-2	gi\|294071	lipoprotein 3 [Pasteurella haemolytica]	344	4.90E-56
EF009-2	gi\|2314748	(AE000654) outer membrane protein [Helicobacter pylori]	319	4.20E-53
EF009-2	gi\|2196996	lipoprotein homolog [Treponema pallidum] >gi\|2108234 29K	312	2.60E-41
		protein
EF009-2	gi\|1336657	lipoprotein [Bacillus subtilis]	234	4.00E-32
EF009-2	gnl\|PID\|e233873	hypothetical protein [Bacillus subtilis] >gnl\|PID\|e1182900	242	1.40E-31
EF009-2	gnl\|PID\|e118435	similar to hypothetical proteins [Bacillus subtilis]	102	6.80E-22
EF011-2	gnl\|PID\|d100965	ferric anguibactin-binding protein precusor FatB of V.	579	3.10E-98
EF011-2	gnl\|PID\|d100965	ferric anguibactin-binding protein precusor FatB of V.	579	3.10E-98
EF011-2	gnl\|PID\|e185374	ceuE gene product [Campylobacter coli]	284	1.30E-89
EF011-2	gnl\|PID\|e185374	ceuE gene product [Campylobacter coli]	284	1.30E-89
EF011-2	gi\|150756	40 kDa protein [Plasmid pJM1] >pir\|A29928\|A29928	222	2.80E-52
		membrane-associated
EF011-2	gi\|150756	40 kDa protein [Plasmid pJM1] >pir\|A29928\|A29928	222	2.80E-52
		membrane-associated
EF012-2	gi\|309662	pheromone binding protein [Plasmid pCF10]	266	8.70E-116
		>pir\|B53309\|B53309
EF012-2	gi\|388269	traC [Plasmid pAD1] >pir\|A53310\|A53310 pheromone cAD1	252	1.10E-109
		binding
EF012-2	gnl\|PID\|d101185	TRAC [Enterococcus faecalis]	281	3.60E-103
EF012-2	gnl\|PID\|d100655	TraC [Enterococcus faecalis]	277	2.30E-102
EF012-2	gi\|312940	threonine kinase [Streptococcus equisimilis]	227	1.90E-67
		>pir\|S28153\|S28153
EF012-2	gi\|48808	dciAE [Bacillus subtilis]	228	1.70E-46
EF012-2	pir\|S16651\|S166	dciAE protein - Bacillus subtilis	228	1.00E-45
EF012-2	gnl\|PID\|e118149	(AJ002571) DppE [Bacillus subtilis] >gnl\|PID\|e1183316	228	3.80E-45
EF012-2	gi\|40005	OppA gene product [Bacillus subtilis]	281	3.90E-44
EF012-2	gi\|143603	sporulation protein [Bacillus subtilis] >gnl\|PID\|e1183163	281	7.70E-44
EF012-2	gnl\|PID\|d101563	Periplasmic oligopeptide-binding protein precursor.	152	2.20E-43
EF012-2	gi\|1574679	oligopeptide binding protein (oppA) [Haemophilus influenzae]	178	2.20E-42
EF012-2	gi\|478020	Opp A (AA1-542) [Salmonella typhimurium] >gi\|47808	128	1.00E-37
		precursor
EF012-2	gi\|882550	ORF_f535 [Escherichia coli] >gi\|1789397 (AE000384) f535;	228	5.30E-36
		This 535 aa
EF014-2	pir\|D70070\|D700	transcriptional regulator homolog ywtF-Bacillus subtilis	101	1.40E-27
EF014-2	gnl\|PID\|e116988	capsular polysaccharide synthesis protein [Streptococcus	121	9.50E-27
EF014-2	gi\|2804769	(AF030373) putative regulatory protein [Streptococcus	121	9.50E-27
		pneumoniae]
EF014-2	gnl\|PID\|e289126	unknown [Streptococcus pneumoniae]	121	1.00E-24
EF014-2	gi\|2267239	ORF1 [Staphylococcus epidermidis]	234	1.50E-24
EF014-2	gi\|485275	putative regulatory protein [Streptococcus pneumoniae]	121	3.90E-24
EF014-2	gi\|2804735	(AF030367) putative regulatory protein [Streptococcus	121	3.90E-24
		pneumoniae]
EF014-2	gi\|2804747	(AF030369) putative regulatory protein [Streptococcus	121	3.90E-24
		pneumoniae]
EF014-2	gi\|1762327	putative transcriptional regulator [Bacillus subtilis]	185	2.80E-22
EF014-2	gi\|143156	membrane bound protein [Bacillus subtilis] >gnl\|PID\|e1184471	116	1.10E-21
EF014-2	gnl\|PID\|d101895	membrane bound protein LytR [Synechocystis sp.]	113	6.20E-20
EF014-2	gi\|1276874	EpsA [Streptococcus thermophilus]	103	4.00E-17
EF016-2	gnl\|PID\|e118566	similar to amino acid ABC transporter (binding protein)	194	3.70E-35
EF016-2	gi\|40934	arginine binding protein [Escherichia coli] >gi\|769794 artJ	121	1.60E-31
EF016-2	gnl\|PID\|d101527	Arginine-binding periplasmic protein 2 precursor [Escherichia	121	4.80E-31
EF016-2	gi\|687652	FliY [Escherichia coli] >gnl\|PID\|d1016464 FliY protein	160	5.70E-31
		precursor.
EF016-2	gi\|2650410	(AE001090) glutamine ABC transporter, periplasmic glutamine-	122	3.30E-29
		binding
EF016-2	gi\|1649035	high-affinity periplasmic glutamine binding protein [Salmonella	104	1.80E-27
EF016-2	gi\|1574634	glutamine-binding periplasmic protein (glnH) [Haemophilus	174	2.50E-27
EF016-2	gi\|41569	GlnH precursor (AA −22 to 226) [Escherichia coli]	106	4.70E-27
		>gnl\|PID\|d1015250
EF016-2	gnl\|PID\|d101527	Arginine-binding periplasmic protein 1 precursor [Escherichia	109	3.70E-26
EF016-2	gi\|769791	artI [Escherichia coli] >gi\|769791 artI [Escherichia coli]	127	2.30E-25
EF016-2	gnl\|PID\|d100892	homologous to Gln-binding periplasmic proteins [Bacillus	117	8.50E-24
EF016-2	gi\|154125	J protein [Salmonella typhimurium] >gi\|47718 reading frame	118	2.10E-23
		hisJ
EF016-2	gnl\|PID\|d101688	HISTIDINE-BINDING PERIPLASMIC PROTEIN	117	4.50E-23
		PRECURSOR (HBP).
EF016-2	gi\|1166636	histidine-binding periplasmic protein HisJ [Escherichia coli]	117	6.60E-23
EF017-2	gi\|388269	traC [Plasmid pAD1] >pir\|A53310\|A53310 pheromone cAD1	421	4.50E-128
		binding
EF017-2	gnl\|PID\|d101185	TRAC [Enterococcus faecalis]	417	5.10E-124
EF017-2	gnl\|PID\|d100655	TraC [Enterococcus faecalis]	414	4.40E-123
EF017-2	gi\|309662	pheromone binding protein [Plasmid pCF10]	415	2.40E-119
		>pir\|B53309\|B53309
EF017-2	gi\|40005	OppA gene product [Bacillus subtilis]	294	6.20E-82
EF017-2	gi\|143603	sporulation protein [Bacillus subtilis] >gnl\|PID\|e1183163	290	2.80E-79
EF017-2	gi\|312940	threonine kinase [Streptococcus equisimilis]	241	2.40E-71
		>pir\|S28153\|S28153
EF017-2	gi\|48808	dciAE [Bacillus subtilis]	270	1.10E-61
EF017-2	gnl\|PID\|e118149	(AJ002571) DppE [Bacillus subtilis] >gnl\|PID\|e1183316	270	1.50E-61
EF017-2	pir\|S16651\|S166	dciAE protein-Bacillus subtilis	270	3.10E-60
EF017-2	gi\|304925	periplasmic oligopeptide binding protein [Escherichia coli]	171	2.60E-57
EF017-2	gi\|147014	oligopeptide binding protein precursor [Escherichia coli]	171	8.70E-56
EF017-2	gi\|47802	Opp A (AA1-542) [Salmonella typhimurium] >gi\|47808	154	1.30E-52
		precursor
EF017-2	gi\|882550	ORF_f535 [Escherichia coli] >gi\|1789397 (AE000384) f535;	135	5.50E-52
		This 535 aa
EF017-2	gi\|1574679	oligopeptide binding protein (oppA) [Haemophilus influenzae]	168	2.90E-43
EF019-2	gi\|438458	likely N-terminal signal sequence; mature protein probably	104	2.30E-17
EF021-2	gnl\|PID\|e311492	unknown [Bacillus subtilis] >gnl\|PID\|e1184232 similar to ABC	317	2.50E-103
EF021-2	bbs\|173803	CD4+ T cell-stimulating antigen [Listeria monocytogenes,	476	2.80E-81
		85EO-1167,
EF021-2	gi\|581809	tmbC gene product [Treponema pallidum] >pir\|A43595\|A43595	152	3.20E-71
		membrane
EF021-2	gi\|2688280	(AE001143) basic membrane protein C (bmpC) [Borrelia	101	5.50E-27
		burgdorferi]
EF021-2	gnl\|PID\|e117283	membrane protein A [Borrelia garinii]	142	6.50E-22
EF021-2	gnl\|PID\|e117283	membrane protein A [Borrelia burgdorferi]	141	9.20E-22
EF021-2	gnl\|PID\|e117283	membrane protein A [Borrelia burgdorferi] >gi\|516592	141	9.20E-22
		membrane
EF021-2	gnl\|PID\|e117283	bmpA(p39,ORF1) [Borrelia burgdorferi]	141	1.70E-21
EF021-2	gi\|508421	antigen P39 [Borrelia burgdorferi] >gi\|2688281 (AE001143)	141	1.70E-21
		basic
EF021-2	gi\|1753225	BmpA protein [Borrelia burgdorferi]	141	2.70E-20
EF021-2	gnl\|PID\|e117282	membrane protein A [Borrelia afzelii]	141	8.60E-20
EF021-2	gnl\|PID\|e117283	membrane protein A [Borrelia afzelii]	141	8.60E-20
EF021-2	gnl\|PID\|e117283	membrane protein A [Borrelia afzelii]	141	8.60E-20
EF021-2	gnl\|PID\|e117282	bmpA(p39,ORF1) [Borrelia burgdorferi]	141	1.50E-19
EF022-2	gi\|312940	threonine kinase [Streptococcus equisimilis]	324	5.90E-66
		>pir\|S28153\|S28153
EF022-2	gi\|309662	pheromone binding protein [Plasmid pCF10]	307	5.60E-60
		>pir\|B53309\|B53309
EF022-2	gnl\|PID\|d101185	TRAC [Enterococcus faecalis]	301	4.80E-59
EF022-2	gnl\|PID\|e118149	(AJ002571) DppE [Bacillus subtilis] >gnl\|PID\|e1183316	170	5.10E-59
EF022-2	gi\|48808	dciAE [Bacillus subtilis]	170	5.20E-59
EF022-2	gnl\|PID\|d100655	TraC [Enterococcus faecalis]	299	2.80E-58
EF022-2	pir\|S16651\|S166	dciAE protein - Bacillus subtilis	170	1.60E-57
EF022-2	gi\|388269	traC [Plasmid pAD1] >pir\|A53310\|A53310 pheromone cAD1	280	2.70E-53
		binding
EF022-2	gi\|40005	OppA gene product [Bacillus subtilis]	154	7.30E-48
EF022-2	gi\|143603	sporulation protein [Bacillus subtilis] >gnl\|PID\|e1183163	154	3.10E-47
EF022-2	gi\|2688227	(AE001139) oligopeptide ABC transporter, periplasmic	215	1.00E-36
EF022-2	gi\|2281458	(AF000366) oligopeptide permease homolog AII [Borrelia	215	1.00E-36
		burgdorferi]
EF022-2	gi\|304925	periplasmic oligopeptide binding protein [Escherichia coli]	131	1.30E-35
EF022-2	gi\|147014	oligopeptide binding protein precursor [Escherichia coli]	131	1.80E-34
EF022-2	gi\|47802	Opp A (AA1-542) [Salmonella typhimurium] >gi\|47808	138	4.90E-34
		precursor
EF023-2	gi\|309662	pheromone binding protein [Plasmid pCF10]	231	4.70E-66
		>pir\|B53309\|B53309
EF023-2	gi\|388269	traC [Plasmid pAD1] >pir\|A53310\|A53310 pheromone cAD1	223	4.80E-62
		binding
EF023-2	gnl\|PID\|d101185	TRAC [Enterococcus faecalis]	226	1.00E-58
EF023-2	gnl\|PID\|d100655	TraC [Enterococcus faecalis]	226	4.40E-58
EF023-2	gi\|48808	dciAE [Bacillus subtilis]	157	1.20E-57
EF023-2	gnl\|PID\|e118149	(AJ002571) DppE [Bacillus subtilis] >gnl\|PID\|e1183316	157	1.20E-57
EF023-2	pir\|S16651\|S166	dciAE protein - Bacillus subtilis	157	3.80E-56
EF023-2	gi\|40005	OppA gene product [Bacillus subtilis]	137	2.30E-53
EF023-2	gi\|143603	sporulation protein [Bacillus subtilis] >gnl\|PID\|e1183163	133	6.90E-53
EF023-2	gi\|47802	Opp A (AA1-542) [Salmonella typhimurium] >gi\|47808	135	2.00E-41
		precursor
EF023-2	gi\|2688227	(AE004139) oligopeptide ABC transportcr, periplasmic	187	9.40E-41
EF023-2	gi\|2281458	(AF000366) oligopeptide permease homolog AII [Borrelia	187	1.90E-40
		burgdorferi]
EF023-2	gi\|882550	ORF_f535 [Escherichia coli] >gi\|1789397 (AE000384) f535;	155	1.30E-38
		This 535 aa
EF023-2	gi\|304925	periplasmic oligopeptide binding protein [Escherichia coli]	130	9.00E-37
EF023-2	gi\|147014	oligopeptide binding protein precursor [Escherichia coli]	130	3.70E-34
EF026-2	gi\|2352482	(AF005097) unknown [Lactococcus lactis]	141	1.10E-23
EF027-2	gi\|309662	pheromone binding protein [Plasmid pCF10]	198	6.20E-71
		>pir\|B53309\|B53309
EF027-2	gnl\|PID\|d100655	TraC [Enterococcus faecalis]	202	1.50E-68
EF027-2	gnl\|PID\|d101185	TRAC [Enterococcus faecalis]	202	1.50E-68
EF027-2	gi\|388269	traC [Plasmid pAD1] >pir\|A53310\|A53310 pheromone cAD1	213	8.30E-68
		binding
EF027-2	gnl\|PID\|e118149	(AJ002571) DppE [Bacillus subtilis] >gnl\|PID\|e1183316	222	3.70E-41
EF027-2	gi\|48808	dciAE [Bacillus subtilis]	222	4.90E-41
EF027-2	pir\|S16651\|S166	dciAE protein - Bacillus subtilis	222	1.10E-39
EF027-2	gi\|40005	OppA gene product [Bacillus subtilis]	251	4.10E-39
EF027-2	gi\|143603	sporulation protein [Bacillus subtilis]> gnl\|PID\|e1183163	247	5.80E-39
EF027-2	gi\|312940	threonine kinase [Streptococcus equisimilis]	233	8.90E-33
		>pir\|S28153\|S28153
EF027-2	gi\|2688227	(AE001139) oligopeptide ABC transporter, periplasmic	131	2.40E-24
EF027-2	gi\|2281458	(AF000366) oligopeptide permease homolog AII [Borrelia	131	2.40E-24
		burgdorferi]
EF027-2	gi\|2281468	(AF000948) OppAIV [Borrelia burgdorferi] >gi\|2689891	117	3.00E-20
		(AE000792)
EF027-2	gi\|1574679	oligopeptide binding protein (oppA) [Haemophilus influenzae]	130	3.50E-20
EF028-2	gnl\|PID\|d102047	B. subtilis alkaline phosphatase IIIA; P19405 secretory	996	3.60E-131
EF028-2	pir\|B39096\|B390	alkaline phosphatase (EC 3.1.3.1) III precursor - Bacillus	982	2.90E-129
EF028-2	gi\|470383	alkaline phosphatase A [Bacillus subtilis] >gnl\|PID\|e1182942	803	4.80E-119
EF028-2	gi\|143324	APase I [Bacillus licheniformis] >pir\|A44828\|A44828 alkaline	184	3.00E-54
EF028-2	gi\|147243	alkaline phosphatase precursor (BC 3.1.3.1) [Escherichia coli]	183	8.30E-54
EF028-2	gi\|147237	alkaline phosphatase precursor (BC 3.1.3.1) [Escherichia coli]	178	4.40E-53
EF028-2	gi\|147239	alkaline phosphatase precursor (BC 3.1.3.1) [Escherichia coli]	178	4.40E-53
EF028-2	gi\|147241	alkaline phosphatase precursor (BC 3.1.3.1) [Escherichia coli]	178	4.40E-53
EF028-2	gi\|1277127	phoA gene product [Cloning vector pFW_phoA1] > gi\|1277130	174	4.90E-53
		phoA gene
EF028-2	gi\|147229	alkaline phosphatase precursor (EC 3.1.3.1) [Escherichia coli]	178	8.40E-53
EF028-2	gi\|818851	alkaline phosphatase [synthetic construct]	174	1.10E-52
EF028-2	gi\|147245	alkaline phosphatase (phoA) (EC 3.1.3.1) [Escherichia	177	1.20E-52
		fergusonii]
EF028-2	gi\|147231	alkaline phosphatase precursor (EC 3.1.3.1) [Escherichia coli]	174	1.60E-52
EF028-2	gi\|147235	alkaline phosphatase precursor (EC 3.1.3.1) [Escherichia coli]	174	1.60E-52
EF028-2	gi\|1016010	alkaline phosphatase with N-terminal PelB-leader and C-	174	1.60E-52
		terminal
EF029-2	gi\|1750126	YncB [Bacillus subtilis] >gnl\|PID\|e1183421 similar to	257	3.50E-55
		micrococcal
EF029-2	gnl\|PID\|e118360	similar to hypothetical proteins [Bacillus subtilis]	263	7.80E-53
EF029-2	gi\|673492	nuclease [Staphylococcus aureus] >pir\|A00790\|NCSAF	320	2.20E-39
		micrococcal
EF029-2	gi\|532653	thermonuclease [Staphylococcus hyicus]	155	9.10E-39
EF029-2	gi\|47146	thermonuclease [Staphylococcus intermedius]	145	4.90E-32
		>pir\|526079\|S26079
EF030-2	gi\|48808	dciAE [Bacillus subtilis]	149	1.10E-66
EF030-2	gnl\|PID\|e118149	(AJ002571) DppE [Bacillus subtilis] >gnl\|PID\|e1183316	149	1.50E-66
EF030-2	pir\|S16651\|S166	dciAE protein - Bacillus subtilis	149	5.90E-66
EF030-2	gi\|309662	pheromone binding protein [Plasmid pCF10]	227	7.40E-52
		>pir\|B53309\|B53309
EF030-2	gnl\|PID\|d101185	TRAC [Enterococeus faecalis]	237	7.40E-52
EF030-2	gnl\|PID\|d100655	TraC [Enterococcus faecalis]	233	9.70E-51
EF030-2	gi\|388269	traC [Plasmid pAD1] >pir\|A53310\|A53310 pheromone cAD1	229	3.00E-48
		binding
EF030-2	gi\|312940	threonine kinase [Streptococcus equisimilis]	277	3.00E-45
		>pir\|S28153\|S28153
EF030-2	gi\|47802	Opp A (AA1-542) [Salmonella typhimurium] >gi\|47808	125	8.50E-34
		precursor
EF030-2	gi\|2688227	(AE001139) oligopeptide ABC transporter, periplasmic	211	4.80E-31
EF030-2	gi\|2281458	(AF000366) oligopeptide permease homolog AII [Borrelia	211	4.80E-31
		burgdorferi]
EF030-2	gi\|40005	OppA gene product [Bacillus subtilis]	148	1.20E-30
EF030-2	gi\|143603	sporulation protein [Bacillus subtilis] >gnl\|PID\|e1183163	144	4.80E-30
EF030-2	gi\|2281468	(AF000948) OppAIV [Borrelia burgdorferi] >gi\|2689891	210	2.10E-29
		(AE000792)
EF030-2	gi\|1574679	oligopeptide binding protein (oppA) [Haemophilus influenzae]	148 6.00E-29
EF033-2	gnl\|PID\|e118439	similar to iron-binding protein [Bacillus subtilis]	164	2.60E-14
EF033-2	pir\|S54437\|S544	hemin binding protein - Yersinia enterocolitica	108	1.40E-11
EF033-2	gi\|1619623	hemin binding protein [Yersinia enterocolitica]	108	2.00E-11
EF036-2	gnl\|PID\|d101022	ORF108 [Bacillus subtilis] >gnl\|PID\|e1185766 alternate gene	544	1.20E-96
EF036-2	gi\|2622858	(AE000929) phosphate-binding protein PstS	183	1.40E-45
		[Methanobacterium
EF036-2	gi\|2622859	(AE000929) phosphate-binding protein PstS homolog	158	2.40E-41
		[Methanobacterium
EF036-2	gi\|2688115	(AE001132) phosphate ABC transporter, periplasmic	117	1.10E-12
		phosphate-binding
EF037-2	gi\|2352482	(AF005097) unknown [Lactococcus lactis]	141	1.10E-23
EF040-2	gi\|1657516	hypothetical protein [Escherichia coli] >gi\|1786511 (AE000139)	208	1.90E-29
EF040-2	gi\|293265	2-5A-dependent RNase [Mus musculus] >pir\|B45771\|B45771	105	1.00E-17
EF040-2	gi\|287865	G9a [Homo sapiens] >pir\|S30385\|S30385 G9a protein - human	143	8.30E-14
EF040-2	gi\|311817	erythroid ankyrin [Mus musculus] >pir\|S37771\|S37771 ankyrin,	119	4.80E-13
EF040-2	gi\|191940	ankyrin [Mus musculus] >pir\|I49502\|I49502 ankyrin - mouse	119	4.90E-13
EF040-2	gi\|747710	alt. ankyrin (variant 2.2) [Homo sapiens]	120	1.50E-12
EF040-2	gi\|178646	ankyrin [Homo sapiens]	120	1.80E-12
EF040-2	gi\|1845265	ankyrin [Homo sapiens]	120	1.80E-12
EF040-2	pir\|A35049\|A350	ankyrin 1, erythrocyte splice form 2-human	120	1.80E-12
EF040-2	pir\|B35049\|B350	ankyrin 1, erythrocyte splice form 3-human	120	1.80E-12
EF040-2	gi\|28702	ankyrin (variant 2.1) [Homo sapiens] >pir\|S08275\|SJHUK	120	1.80E-12
		ankyrin 1,
EF041-2	gi\|388269	traC [Plasmid pAD1] >pir\|A53310\|A53310 pheromone cAD1	670	1.40E-87
		binding
EF041-2	gnl\|PID\|d100655	TraC [Enterococcus faecalis]	662	1.50E-85
EF041-2	gnl\|PID\|d101185	TRAC [Enterococcus faecalis]	662	1.50E-85
EF041-2	gi\|309662	pheromone binding protein [Plasmid pCF10]	648	1.20E-83
		>pir\|B53309\|B53309
EF041-2	gi\|48808	dciAE [Bacillus subtilis]	218	1.20E-57
EF041-2	gnl\|PID\|e118149	(AJ002571) DppE [Bacillus subtilis] >gnl\|PID\|e1183316	218	1.40E-57
EF041-2	pir\|S16651\|S166	dciAE protein - Bacillus subtilis	218	2.10E-56
EF041-2	gi\|882550	ORF_f535 [Escherichia coli] >gi\|1789397 (AE000384) f535;	146	7.30E-40
		This 535 aa
EF041-2	gi\|143603	sporulation protein [Bacillus subtilis] >gnl\|PID\|e1183163	278	1.00E-34
EF041-2	gi\|40005	OppA gene product [Bacillus subtilis]	279	1.00E-34
EF041-2	gi\|47802	Opp A (AA1-542) [Salmonella typhimurium] >gi\|47808	141	6.60E-30
		precursor
EF041-2	gi\|304925	periplasmic oligopeptide binding protein [Escherichia coli]	160	1.90E-29
EF041-2	gi\|1574679	oligopeptide binding protein (oppA) [Haemophilus influenzae]	163	1.00E-28
EF041-2	gi\|147014	oligopeptide binding protein precursor [Escherichia coli]	160	1.50E-28
EF041-2	gi\|2253286	(AF005657) plasminogen binding protein [Borrelia burgdorferi]	134	5.00E-27
EF045-2	gi\|308854	oligopeptide binding protein [Lactococcus lactis]	437	3.20E-125
		>pir\|E53290\|E53290
EF045-2	gi\|495181	oligopeptide binding protein [Lactococcus lactis]	426	9.70E-124
EF045-2	gi\|677945	AppA [Bacillus subtilis] >gnl\|PID\|e1183158 oligopeptide ABC	154	2.30E-31
EF045-2	gi\|293014	peptide-binding protein [Lactococcus lactis]	158	2.40E-14
	>pir\|B47098\|B47098
EF048-2	gi\|1574060	hypothetical [Haemophilus influenzae] >pir\|I64164\|I64164	250	2.30E-41
EF048-2	dbj\|\|AB0014882	(AB001488) SIMILAR TO C4-DICARBOXYLATE-	208	3.60E-34
		BINDING PERIPLASMIC
EF048-2	gi\|466717	No definition line found [Escherichia coli] >gi\|1790004	199	1.30E-30
		(AE000435)
EF048-2	gi\|46006	periplasmic C4-dicarboxylate binding-protein [Rhodobacter	162	1.40E-25
		capsulatus]
EF048-2	gi\|1573102	hypothetical [Haemophilus influenzae] >pir\|H641431\|H64143	244	3.80E-25
EF048-2	gi\|2182530	(AE000085) Y4mM [Rhizobium sp. NGR234]	114	5.60E-18
EF048-2	gi\|1572999	hypothetical [Haemophilus influenzae] >pir\|E64141\|E64141	116	5.90E-15
EF049-2	gi\|149581	maturation protein [Lactobacillus paracasei]	241	2.40E-55
		>pir\|A44858\|A44858
EF049-2	gi\|47198	ORF (AA 1 to 299) [Lactococcus lactis cremoris]	239	1.00E-54
		>pir\|S08083\|S08083
EF049-2	gi\|432402	maturation protein [Lactococcus lactis] >gi\|623055 proteinase	239	6.20E-54
EF049-2	gi\|472835	ORF1 [Lactococcus lactis cremoris]	241	1.50E-53
EF049-2	gi\|39782	33kDa lipoprotein [Bacillus subtilis] >gnl\|PID\|e325181 33kDa	128	8.90E-40
EF051-2	gnl\|PID\|d101142	molybdate-binding periplasmic protein [Synechocystis sp.]	173	3.20E-50
EF051-2	gnl\|PID\|e118602	alternate gene name: yvsD; similar to molybdate-binding	314	5.90E-50
EF051-2	gi\|1574546	lsg locus hypothetical [Haemophilus influenzae]	161	2.20E-43
		>pir\|A64175\|A64175
EF051-2	gi\|504498	periplasmic molybdate-binding protein [Escherichia coli]	148	1.40E-30
		>gi\|1147817
EF051-2	gi\|148939	ORF 8 [Haemophilus influenzae] >pir\|S27583\|S27S83	150	8.10E-28
		hypothetical
EF054-2	gi\|150556	surface protein [Plasmid pCF10] >pir\|A41826\|A41826 probable	1490	1.80E-192
EF054-2	gnl\|PID\|e236571	cell wall anchoring signal [Enterococcus faecalis]	515	8.10E-64
EF054-2	gi\|45738	ORFC [Enterococcus faecalis] >pir\|JH0204\|JH0204	372	1.60E-58
		hypothetical 30.5K
EF054-2	gi\|496520	orf iota [Streptococcus pyogenes] >pir\|S68125\|S45091	362	1.30E-43
		hypothetical
EF054-2	gi\|160693	sporozoite surface protein [Plasmodium yoelii]	286	4.30E-33
		>pir\|A45559\|A45559
EF054-2	gi\|1813523	PbTRAP [Plasmodium berghei]	305	1.30E-32
EF054-2	gnl\|PID\|e225687	zinc finger protein [Mus musculus] >gnl\|PID\|e225688 zinc	246	3.60E-26
EF054-2	gi\|2290394	IgG and IgE immunoreactive antigen recognized by sera from	242	1.40E-25
		patients
EF054-2	gi\|2290392	IgG and IgE immunoreactive antigen recognized by sera from	237	7.80E-25
		patients
EF054-2	gi\|46523	B antigen [Streptococcus agalactiae]	232	2.80E-23
EF054-2	pir\|S15330\|FCSO	IgA Fc receptor precursor - Streptococcus agalactiae	228	1.00E-22
EF054-2	gi\|1620100	Pro- and Glu-rich, PENPEV (10×); similar to Streptococcus B	210	3.10E-21
EF054-2	gi\|63686	NF-M c-terminus [Gallus gallus]	222	6.90E-21
EF054-2	gi\|63689	NF-M protein [Gallus gallus] >pir\|S15762\|S15762	222	8.50E-21
		neurofilament triplet
EF054-2	gi\|757867	TATA-box like sequence (Us11) [Human herpesvirus 1]	194	4.10E-19
		>gi\|291493 18
EF059-2	gnl\|PID\|e236571	cell wall anchoring signal [Enterococcus faecalis]	418	5.60E-95
EF059-2	gi\|150556	surface protein [Plasmid pCF10] >pir A41826\|A41826 probable	606	3.70E-87
EF059-2	gi\|45738	ORFC [Enterococcus faecalis] >pir\|JH0204\|JH0204	366	9.30E-50
		hypothetical 30.5K
EF059-2	gi\|496520	orf iota [Streptococcus pyogenes] >pir\|S68125\|S545091	367	5.90E-44
		hypothetical
EF059-2	gi\|160693	sporozoite surface protein [Plasmodium yoelii]	344	1.10E-38
		>pir\|A45559\|A45559
EF059-2	gi\|1813523	PbTRAP [Plasmodium berghei]	295	2.50E-32
EF059-2	gi\|2290394	IgG and IgE immunoreactive antigen recognized by sera from	251	3.00E-29
		patients
EF059-2	gi\|2290392	IgG and IgE immunoreactive antigen recognized by sera from	251	3.40E-29
		patients
EF059-2	gi\|162100	Pro- and Glu-rich, PENPEV (10×); similar to Streptococcus B	253	6.40E-27
EF059-2	gi\|46521	Fc receptor [Streptococcus agalactiae] >pir\|A60234\|A60234 IgA	197	2.70E-26
		Fc
EF059-2	gi\|46523	B antigen [Streptococcus agalactiae]	232	9.30E-26
EF059-2	pir\|S15330\|FCSO	IgA Fc receptor precursor - Streptococcus agalactiae	232	9.30E-26
EF059-2	gnl\|PID\|e225687	zinc finger protein [Mus musculus] >gnl\|PID\|e225688 zinc	234	1.40E-22
EF059-2	gi\|425356	zona pellucida protein [Pseudopleuronectes americanus]	229	1.00E-21
EF059-2	gi\|457769	Collagen [Bombyx mori] >pir\|S42886\|S42886 collagen -	209	7.60E-19
		silkworm
EF061-2	gnl\|PID\|e236571	cell wall anchoring signal [Enterococcus faecalis]	925	8.10E-118
EF061-2	gi\|150556	surface protein [Plasmid pCF10] >pir\|A41826\|A41826 probable	350	1.50E-107
EF061-2	gi\|496520	orf iota [Streptococcus pyogenes] >pir\|S68125\|S45091	308	1.40E-58
		hypothetical
EF061-2	gi\|45738	ORFC [Enterococcus faecalis] >pir\|JH0204\|JH0204	322	6.40E-50
		hypothetical 30.5K
EF061-2	gi\|1813523	PbTRAP [Plasmodium berghei]	263	1.00E-26
EF061-2	gi\|160693	sporozoite surface protein [Plasmodium yoelii]	241	9.00E-25
		>pir\|A45559\|A45559
EF061-2	gi\|63686	NF-M c-terminus [Gallus gallus]	232	2.10E-22
EF061-2	gi\|63689	NF-M protein [Gallus gallus] >pir\|S15762\|S15762	232	2.60E-22
		neurofilament triplet
EF061-2	gi\|2290392	IgG and IgE immunoreactive antigen recognized by sera from	176	2.40E-21
		patients
EF061-2	gi\|1620100	Pro- and Glu-rich, PENPEV (10×); similar to Streptococcus B	165	2.70E-20
EF061-2	gnl\|PID\|e225687	zinc finger protein [Mus musculus] >gnl\|PID\|e225688 zinc	197	7.80E-19
EF061-2	gi\|160355	interspersed repeat antigen [Plasmodium falciparum]	199	8.20E-18
EF061-2	gi\|410750	interspersed repeat antigen [Plasmodium falciparum]	199	8.90E-18
EF061-2	gi\|2290388	IgG and IgE immunoreactive antigen recognized by sera from	182	1.40E-17
		patients
EF061-2	gi\|2290394	IgG and IgE immunoreactive antigen recognized by sera from	180	2.80E-17
		patients
EF062-2	gi\|47049	asal gene product (AA 1-1296) [Enterococcus faecalis]	3716	0
EF062-2	gi\|43324	aggregation substance (ASP1) [Enterococcus faecalis]	4003	0
EF062-2	gi\|2109266	aggregation substance [Enterococcus faecium]	5523	0
EF062-2	gi\|150555	aggregation substance [Plasmid pCF10] >pir\|H41662\|H41662	6338	0
		150K mating
EF062-2	gi\|1100973	SspB precursor [Streptococcus gordonii]	110	9.90E-39
EF062-2	gi\|47248	PAc protein precursor (AA −38 to 1527) [Streptococcus	107	1.70E-38
		mutans]
EF062-2	gnl\|PID\|d101507	surface protein antigen precursor [Streptococcus sobrinus]	132	5.00E-36
EF062-2	gi\|47267	cell surface antigen I/II [Streptococcus mutans]	107	6.50E-36
		>pir\|S06839\|S06839
EF062-2	bbs\|148453	SpaA=endocarditis immunodominant antigen [Streptococcus	132	1.20E-35
		sobrinus,
EF062-2	gi\|47620	antigen I/II [Streptococcus sobrinus] >pir\|A60338\|A60338	132	2.90E-35
		surface
EF062-2	pir\|A35186\|A351	salivary agglutinin receptor precursor - Streptococcus	109	2.10E-34
EF062-2	gi\|1100971	SspA [Streptococcus gordonii]	110	3.80E-32
EF062-2	gi\|1100975	SspA [Streptococcus gordonii]	110	2.30E-21
EF063-2	gi\|47049	asal gene product (AA 1-1296) [Enterococcus faecalis]	3716	0
EF063-2	gi\|43324	aggregation substance (ASP1) [Enterococcus faecalis]	4003	0
EF063-2	gi\|2109266	aggregation substance [Enterococcus faecium]	5523	0
EF063-2	gi\|150555	aggregation substance [Plasmid pCF10] >pir\|H41662\|H41662	6338	0
		150K mating
EF063-2	gi\|1100973	SspB precursor [Streptococcus gordonii]	110	9.90E-39
EF063-2	gi\|47248	PAc protein precursor (AA −38 to 1527) [Streptococcus	107	1.70E-38
		mutans]
EF063-2	gnl\|PID\|d101507	surface protein antigen precursor [Streptococcus sobrinus]	132	5.00E-36
EF063-2	gi\|47267	cell surface antigen I/II [Streptococcus mutans]	107	6.50E-36
		>pir\|S06839\|S06839
EF063-2	bbs\|148453	SpaA=endocarditis immunodominant antigen [Streptococcus	132	1.20E-35
		sobrinus,
EF063-2	gi\|47620	antigen I/II [Streptococcus sobrinus] >pir\|A60338\|A60338	132	2.90E-35
		surface
EF063-2	pir\|A35186\|A351	salivary agglutinin receptor precursor - Streptococcus	109	2.10E-34
EF063-2	gi\|1100971	SspA [Streptococcus gordonii]	110	3.80E-32
EF063-2	gi\|1100975	SspA [Streptococcus gordonii]	110	2.30E-21
EF064-2	gi\|47049	asal gene product (AA 1-1296) [Enterococcus faecalis]	3716	0
EF064-2	gi\|43324	aggregation substance (ASP1) [Enterococcus faecalis]	4003	0
EF064-2	gi\|2109266	aggregation substance [Enterococcus faecium]	5523	0
EF064-2	gi\|150555	aggregation substance [Plasmid pCF10] >pir\|H41662\|H41662	6338	0
		150K mating
EF064-2	gi\|1100973	SspB precursor [Streptococcus gordonii]	110	9.90E-39
EF064-2	gi\|47248	PAc protein precursor (AA −38 to 1527) [Streptococcus	107	1.70E-38
		mutans]
EF064-2	gnl\|PID\|d101507	surface protein antigen precursor [Streptococcus sobrinus]	132	5.00E-36
EF064-2	gi\|47267	cell surface antigen I/II [Streptococcus mutans]	107	6.50E-36
		>pir\|S06839\|S06839
EF064-2	bbs\|148453	SpaA=endocarditis immunodominant antigen [Streptococcus	132	1.20E-35
		sobrinus,
EF064-2	gi\|47620	antigen I/II [Streptococcus sobrinus] >pir\|A60338\|A60338	132	2.90E-35
		surface
EF064-2	pir\|A35186\|A351	salivary agglutinin receptor precursor - Streptococcus	109	2.10E-34
EF064-2	gi\|1100971	SspA [Streptococcus gordonii]	110	3.80E-32
EF064-2	gi\|1100975	SspA [Streptococcus gordonii]	110	2.30E-21
EF068-2	gi\|790398	T06D8.1 [Caenorhabditis elegans]	137	8.50E-17
EF068-2	gnl\|PID\|d102084	membrane glycoprotein [Equine herpesvirus 1]	210	5.80E-16
EF068-2	gi\|2286204	(AF011339) unknown [Acinetobacter calcoaceticus]	121	8.40E-16
EF068-2	gi\|330862	membrane glycoprotein [Equine herpesvirus 1]	208	1.10E-15
		>pir\|H36802\|VGBEX1
EF068-2	gi\|1707247	partial CDS [Caenorhabditis elegans]	131	3.70E-15
EF068-2	gnl\|PID\|d102084	membrane glycoprotein [Equine herpesvirus 1]	203	6.20E-15
EF068-2	gi\|213392	antifreeze glycoprotein [Notothenia coriiceps]	102	4.60E-13
		>pir\|A38420\|A38420
EF068-2	gnl\|PID\|e125464	(AL022022) PGRS-family protein [Mycobacterium	145	1.50E-12
		tuberculosis]
EF068-2	gi\|951460	FIM-C.1 gene product [Xenopus laevis] >pir\|A45155\|A45155	109	2.70E-12
		mucin
EF069-2	gi\|790398	T06D8.1 [Caenorhabditis elegans]	137	8.50E-17
EF069-2	gnl\|PID\|d102084	membrane glycoprotein [Equine herpesvirus 1]	210	5.80E-16
EF069-2	gi\|2286204	(AF011339) unknown [Acinetobacter calcoaceticus]	121	8.40E-16
EF069-2	gi\|330862	membrane glycoprotein [Equine herpesvirus1]	208	1.10E-15
		>pir\|H36802\|VGBEX1
EF069-2	gi\|1707247	partial CDS [Caenorhabditis elegans]	131	3.70E-15
EF069-2	gnl\|PID\|d102084	membrane glycoprotein [Equine herpesvirus 1]	203	6.20E-15
EF069-2	gi\|213392	antifreeze glycoprotein [Notothenia coriiceps]	102	4.60E-13
		>pir\|A38420\|A38420
EF069-2	gnl\|PID\|e125464	(AL022022) PGRS-family protein [Mycobacterium	145	1.50E-12
		tuberculosis]
EF069-2	gi\|951460	FIM-C.1 gene product [Xenopus laevis] >pir\|A45155\|A45155	109	2.70E-12
		mucin
EF070-2	gi\|790398	T06D8.1 [Caenorhabditis elegans]	137	8.50E-17
EF070-2	gnl\|PID\|d102084	membrane glycoprotein [Equine herpesvirus 1]	210	5.80E-16
EF070-2	gi\|2286204	(AF011339) unknown [Acinetobacter calcoaceticus]	121	8.40E-16
EF070-2	gi\|330862	membrane glycoprotein [Equine herpesvirus 1]	208	1.10E-15
		>pir\|H36802\|VGBEX1
EF070-2	gi\|1707247	partial CDS [Caenorhabditis elegans]	131	3.70E-15
EF070-2	gnl\|PID\|d102084	membrane glycoprotein [Equine herpesvirus 1]	203	6.20E-15
EF070-2	gi\|213392	antifreeze glycoprotein [Notothenia coriiceps]	102	4.60E-13
		>pir\|A38420\|A38420
EF070-2	gnl\|PID\|e125464	(AL022022) PGRS-family protein [Mycobacterium	145	1.50E-12
		tuberculosis]
EF070-2	gi\|951460	FIM-C.1 gene product [Xenopus laevis] >pir\|A45155\|A45155	109	2.70E-12
		mucin
EF071-2	gnl\|PID\|e306428	unnamed protein product [Bacteriophage rlt] >gi\|1353566	127	2.00E-37
		Lysin
EF071-2	gi\|853751	N-acetylmuramoyl-L-alanine amidase [Bacteriophage A511]	273	2.60E-36
EF073-2	gi\|143830	xpaC [Bacillus subtilis] > gnl\|PID\|d1005803 hydrolysis of	173	7.10E-16
EF074-2	gi\|1256698	chitinase [Serratia marcescens] >gi\|1256698 chitinase [Serratia	618	2.60E-104
EF074-2	gi\|1763985	chitinase A [Vibrio harveyi]	526	2.80E-84
EF075-2	gi\|143156	membrane bound protein [Bacillus subtilis] >gnl\|PID\|e1184471	593	1.70E-91
EF075-2	pir\|D70070\|D700	transcriptional regulator homolog ywtF-Bacillus subtilis	118	1.90E-59
EF075-2	gi\|1762327	putative transcriptional regulator [Bacillus subtilis]	148	9.60E-53
EF075-2	gi\|1276874	EpsA [Streptococcus thermophilus]	239	2.20E-33
EF075-2	gnl\|PID\|e289126	unknown [Streptococcus pneumoniae]	150	1.20E-27
EF075-2	gi\|485275	putative regulatory protein [Streptococcus pneumoniae]	150	2.50E-27
EF075-2	gi\|2804735	(AF030367) putative regulatory protein [Streptococcus	150	2.50E-27
		pneumoniae]
EF075-2	gi\|2804747	(AF030369) putative regulatory protein [Streptococcus	150	2.50E-27
		pneumoniae]
EF075-2	gnl\|PID\|e116988	capsular polysaccharide synthesis protein [Streptococcus	148	5.30E-27
EF075-2	gi\|2804769	(AF030373) putative regulatory protein [Streptococcus	148	5.30E-27
		pneumoniae]
EF075-2	gi\|1147744	PSR [Enterococcus hirae]	109	2.10E-23
EF075-2	gi\|790435	PSR [Enterococcus faecium] >pir\|S54177\|S54177 PSR protein -	102	4.40E-19
EF075-2	gi\|2267239	ORF1 [Staphylococcus epidermidis]	109	8.50E-19
EF075-2	gnl\|PID\|d101895	membrane bound protein LytR [Synechocystis sp.]	121	2.80E-16
EF077-2	gnl\|PID\|d101135	cadmium-transporting ATPase [Synechocystis sp.]	396	2.30E-113
EF077-2	gi\|150719	cadmium resistance protein [Plasmid pI258]	373	8.60E-112
		>pir\|A32561\|A32561
EF077-2	gi\|143753	cadmium-efflux ATPase [Bacillus firmus] >pir\|D42707\|D42707	361	8.10E-111
		probable
EF077-2	gi\|152978	E1-E2 cadmium efflux adenosine triphosphatase	381	4.30E-110
		[Staphylococcus
EF077-2	gnl\|PID\|e248808	unknown [Mycobacterium tuberculosis]	298	3.50E-107
EF077-2	gi\|495646	ATPase [Transposon Tn5422]	361	2.10E-106
EF077-2	gnl\|PID\|e118497	similar to heavy metal-transporting ATPase [Bacillus	286	3.50E-104
EF077-2	gi\|1699049	cadmium resistance protein [Lactococcus lactis]	352	3.60E-100
EF077-2	gnl\|PID\|e118603	similar to heavy metal-transporting ATPase [Bacillus	254	9.90E-100
EF077-2	gnl\|PID\|e306540	unknown [Mycobacterium tuberculosis]	352	5.20E-88
EF077-2	gnl\|PID\|e263525	P-type ATPase [Mycobacterium tuberculosis]	199	5.50E-86
		>gnl\|PID\|e249413
EF077-2	gnl\|PID\|e264090	unknown [Mycobacterium tuberculosis]	250	3.00E-84
EF077-2	gnl\|PID\|d101135	cadmium-transporting ATPase [Synechocystis sp.]	260	1.00E-81
EF077-2	gi\|1773166	probable copper-transporting atpase [Escherichia coli]	212	4.70E-80
		>gi\|1786691
EF077-2	gi\|1354935	probable copper-transporting atpase [Escherichia coli]	212	8.50E-79
EF078-2	gi\|143331	alkaline phosphatase regulatory protein [Bacillus subtilis]	257	5.50E-58
EF078-2	gi\|410142	ORFX18 [Bacillus subtilis] >gnl\|PID\|e1185580 two-component	235	8.20E-51
		sensor
EF078-2	gnl\|PID\|d101196	homologous to sp:PHOR_BACSU [Bacillus subtilis]	219	4.20E-44
EF078-2	gi\|1575578	histidine protein kinase [Thermotoga maritima]	191	7.10E-44
EF078-2	gi\|2182990	histidine kinase [Lactococcus lactis cremoris]	169	6.40E-40
EF078-2	gi\|2182992	histidine kinase [Lactococcus lactis cremoris]	152	1.10E-39
EF078-2	gnl\|PID\|d101134	sensory transduction histidine kinase [Synechocystis sp.]	259	3.90E-38
EF078-2	gi\|149296	phosphate regulatory protein phoR (gtg start codon) [Klebsiella	228	7.60E-33
EF078-2	gi\|581188	phoR gene product (AA 1-431) [Escherichia coli] >gi\|1657596	226	1.60E-32
EF078-2	gnl\|PID\|d101087	sensory transduction histidine kinase [Synechocystis sp.]	138	3.70E-32
EF078-2	gnl\|PID\|e266592	unknown [Mycobacterium tuberculosis]	232	1.10E-31
EF078-2	gi\|2182996	histidine kinase [Lactococcus lactis cremoris]	206	1.30E-31
EF078-2	gnl\|PID\|d101135	sensory transduction histidine kinase [Synechocystis sp.]	256	1.30E-31
EF078-2	gi\|294893	phosphate regulatory protein phoR (gtg start codon) [Shigella	225	1.60E-31
EF078-2	gi\|288420	drug sensory protein A [Synechocystis PCC6803]	106	2.50E-31
		>gnl\|PID\|d1017420
EF079-2	gi\|2098719	putative fimbrial-associated protein [Actinomyces naeslundii]	183	8.60E-26
EF081-2	gi\|467806	penicillin-binding protein [Enterococcus faecalis]	1356	2.10E-178
EF081-2	gi\|790429	low affinity penicillin-binding protein 5 (PBP5) [Enterococcus	607	1.00E-78
EF081-2	gnl\|PID\|e208365	penicillin-binding protein 5 [Enterococcus faecium]	604	1.10E-78
EF081-2	gi\|790433	low affinity penicillin-binding protein 5 (PBP5) [Enterococcus	604	2.70E-78
		lysin
EF084-2	gi\|2293312	(AF008220) YtfP [Bacillus subtilis] >gnl\|PID\|e1185879 similar	438	1.70E-140
		to
EF084-2	gi\|2367234	(AE000425) hypothetical 43.8 kD protein in rhsB-pit intergenic	167	2.20E-51
EF084-2	gi\|912464	No definition line found [Escherichia coli]	167	6.00E-51
EF084-2	gnl\|PID\|d101127	hypothetical protein [Synechocystis sp.] >pir\|S76678\|S76678	151	6.10E-42
EF084-2	gi\|1573954	hypothetical [Haemophilus influenzae] >pir\|G64161\|G64161	142	2.90E-40
EF085-2	gi\|1209527	protein histidine kinase [Enterococcus faecalis]	2023	8.00E-279
EF085-2	gi\|467057	phoR; B2168_C3_247 [Mycobacterium leprae]	226	8.80E-23
		>pir\|S72905\|S72905
EF085-2	gnl\|PID\|e119229	SenX3 [Mycobacterium bovis BCG]	222	3.10E-22
EF085-2	gnl\|PID\|e255152	unknown [Mycobacterium tuberculosis] >gnl\|PID\|e321546	222	3.10E-22
		SenX3
EF085-2	gi\|1778485	PcoS homolog [Escherichia coli] >gi\|1786783 (AE000162) f480;	111	3.80E-16
		This
EF085-2	gi\|149296	phosphate regulatory protein phoR (gtg start codon) [Klebsiella	110	1.40E-14
EF085-2	gi\|581188	phoR gene product (AA 1-431) [Escherichia coli] >gi\|1657596	103	5.30E-14
EF085-2	gi\|143331	alkaline phosphatase regulatory protein [Bacillus subtilis]	118	4.90E-13
EF085-2	gi\|537239	alternate gene name phoM; CG Site No. 395 [Escherichia coli]	126	9.50E-13
EF085-2	gi\|147251	phoM [Escherichia coli] >gi\|809670 phoM protein (1 is 3rd	126	9.50E-13
		base in
EF085-2	gi\|2182992	histidine kinase [Lactococcus lactis cremoris]	109	5.90E-12
EF086-2	gi\|437706	alternative truncated translation product from E. coli	221	3.00E-54
		[Streptococcus
EF086-2	gi\|437705	hyaluronidase [Streptococcus pneumoniae]	221	1.60E-53
EF086-2	gi\|595847	hyaluronate lyase [Streptococcus agalactiae]	203	3.30E-44
		>pir\|A55137\|A55137
EF086-2	gi\|705406	hyaluronate lyase [Staphylococcus aureus]	191	3.40E-42
EF086-2	gi\|562086	hyaluronidase [Propionibacterium acnes]	198	6.00E-27
EF087-2	gi\|437706	alternative truncated translation product from E. coli	221	3.00E-54
		[Streptococcus
EF087-2	gi\|437705	hyaluronidase [Streptococcus pneumoniae]	221	1.60E-53
EF087-2	gi\|595847	hyaluronate lyase [Streptococcus agalactiae]	203	3.30E-44
		>pir\|A55137\|A55137
EF087-2	gi\|705406	hyaluronate lyase [Staphylococcus aureus]	191	3.40E-42
EF087-2	gi\|562056	hyaluronidase [Propionibacterium acnes]	198	6.00E-27
EF088-2	gi\|437706	alternative truncated translation product from E.coli	221	3.00E-54
		[Streptococcus
EF088-2	gi\|437705	hyaluronidase [Streptococcus pneumoniae]	221	1.60E-53
EF088-2	gi\|595847	hyaluronate lyase [Streptococcus agalactiae]	203	3.30E-44
		>pir\|A55137\|A55137
EF088-2	gi\|705406	hyaluronate lyase [Staphylococcus aureus]	191	3.40E-42
EF088-2	gi\|562086	hyaluronidase [Propionibacterium acnes]	198	6.00E-27
EF091-2	gi\|556016	similar to plant water stress proteins; ORF2 [Bacillus subtilis]	198	5.50E-21
EF091-2	gi\|2353333	(AF016513) Ce-LEA [Caenorhabditis elegans]	189	2.40E-17
EF091-2	gnl\|PID\|e353216	seed maturation protein homolog [Arabidopsis thaliana]	146	3.60E-11
EF091-2	gi\|1161171	late embryogenesis abundant protein [Picea glauca]	132	5.70E-11
EF091-2	pir\|S04909\|S049	embryonic protein DC8 (clone 8/10) - carrot	127	6.50E-11
EF092-2	gi\|2689898	(AE000792) PTS system, cellobiose-specific IIB component	145	4.00E-27
		(celA)
EF092-2	gnl\|PID\|d102048	B. subtilis, cellobiose phosphotransferase system, celA;	116	1.40E-26
EF096-2	gi\|147329	transport protein [Escherichia coli] >gnl\|PID\|d1015409	532	2.10E-91
EF096-2	gi\|1573475	spermidine/putrescine-binding periplasmic protein precursor	527	1.10E-79
		(potD)
EF096-2	gi\|1574803	spermidine/putrescine-binding periplasmic protein precursor	468	1.60E-75
		(potD)
EF096-2	gi\|1142681	Lpp38 [Pasteurella haemolytica]	446	4.40E-72
EF096-2	gnl\|PID\|d101526	Putrescine transport protein PotF [Escherichia coli]	216	1.50E-54
EF096-2	gi\|147334	periplasmic putrescine binding protein [Escherichia coli]	216	2.10E-53
EF096-2	gi\|2688565	(AB001165) spermidine/putrescine ABC transporter,	240	2.00E-48
EF096-2	gi\|1881733	PotD [Salmonella typhimurium]	253	2.70E-28
EF096-2	gnl\|PID\|d101926	spermidine/putrescine-binding periplasmic protein	243	4.20E-26
EF096-2	gnl\|PID\|e152543	potF gene product [Clostridium perfringens]	204	3.30E-21
EF097-2	gi\|622991	mannitol transport protein [Bacillus stearothermophilus]	547	4.90E-93
EF097-2	gi\|42034	mannitol permease [Escherichia coli] >gi\|466737 mannitol-	535	5.50E-85
		specific
EF097-2	gi\|633650	enzyme II(mannitol) [Staphylococcus carnosus]	516	2.10E-82
		>pir\|S68193\|S22385
EF097-2	gi\|882462	protein-N(pi)-phosphohistidine-sugar phosphotransferase	509	3.00E-76
		[Escherichia
EF097-2	gi\|312763	protein-N(pi)-phosphohistidine-sugar phosphotransferase	357	7.50E-70
		[Escherichia
EF097-2	gnl\|PID\|d100966	homologue of mannitol transport protein of B.	492	3.10E-62
EF097-2	gnl\|PID\|d100792	mannitol-specific phophotransferase enzyme II [Bacillus	484	5.20E-61
EF097-2	gi\|1673855	(AE000020) Mycoplasma pneumoniae, PTS system mannitol-	232	3.50E-59
		specific
EF097-2	gnl\|PID\|d100651	phosphotransferase enzymeII, mannitol-specific [Mycoplasma	158	8.20E-18
EF097-2	pir\|S77757\|S777	phosphotransferase system enzyme II (EC 2.7.1.69),	103	2.00E-13
EF100-2	gi\|2058546	Com YC [Streptococcus gordonii]	193	7.30E-27
EF100-2	gi\|2058546	Com YC [Streptococcus gordonii]	193	7.30E-27
EF100-2	gi\|142708	comG3 gene product [Bacillus subtilis] >gnl\|PID\|e1185739	150	2.90E-22
		comGC
EF100-2	gi\|142708	comG3 gene product [Bacillus subtilis] >gnl\|PID\|e1185739	150	2.90E-22
		comGC
EF100-2	gi\|148437	secretory component [Erwinia chrysanthemi]	134	4.40E-15
		>pir\|E47021\|E47021 pectic
EF100-2	gi\|148437	secretory component [Erwinia chrysanthemi]	134	4.40E-15
		>pir\|E47021\|E47021 pectic
EF100-2	gi\|606262	ORF_o145 [Escherichia coli] >gi\|693706 HopG [Escherichia	136	9.10E-13
		coli]
EF100-2	gi\|606262	ORF_o145 [Escherichia coli] >gi\|693706 HopG [Escherichia	136	9.10E-13
		coli]
EF100-2	gi\|38828	ExeG gene product [Aeromonas hydrophila]	132	3.50E-12
		>pir\|S22910\|149905 protein
EF100-2	gi\|38828	ExeG gene product [Aeromonas hydrophila]	132	3.50E-12
		>pir\|S22910\|149905 protein
EF100-2	gnl\|PID\|e117259	etpG [Escherichia coli]	131	5.10E-12
EF100-2	gnl\|PID\|e117259	etpG [Escherichia coli]	131	5.10E-12
EF100-2	gi\|42189	outG gene product [Erwinia carotovora] >pir\|S32861\|S32861	130	9.90E-12
		outG
EF100-2	gi\|42189	outG gene product [Erwinia carotovora] >pir\|S32861\|S32861	130	9.90E-12
		outG
EF100-2	gi\|609628	putative [Vibrio cholerae]	128	1.60E-11
EF100-2	gi\|609628	putative [Vibrio cholerae]	128	1.60E-11
EF101-2	gnl\|PID\|d102573	bacG [Enterococcus faecalis]	106	3.60E-17
EF101-2	gnl\|PID\|e321943	hypothetical protein [Enterococcus faecalis] >gnl\|PID\|e321943	105	1.80E-16
EF101-2	gnl\|PID\|e118502	similar to hypothetical proteins from B. subtilis [Bacillus	113	1.80E-15
EF110-2	gi\|43338	Staphylococcal serine proteinase homologue [Enterococcus	1462	2.30E-195
		faecalis]
EF110-2	gnl\|PID\|d100108	glutamic acid specific protease prepropeptide [Staphylococcus	106	3.70E-14
EF110-2	gi\|46687	preproenzyme (AA −68 to 268) [Staphylococcus aureus]	106	6.70E-14
EF111-2	gi\|606018	ORF_o783 [Escherichia coli] >gi\|1789462 (AE000390)	477	8.10E-80
		hypothetical 88.3
EF121-2	gi\|2626826	YfkN [Bacillus subtilis] >gnl\|PID\|e1182774 similar to	143	1.30E-96
FE121-2	gi\|2313187	(AE000532) 2′,3′-cyclic-nucleotide 2′-phosphodiesterase (cpdB)	413	2.60E-82
EF121-2	gi\|48453	5′-nucleotidase [Vibrio parahaemolyticus] >gnl\|PID\|d1001218	279	8.50E-47
EF121-2	gi\|757842	UDP-sugar hydrolase [Escherichia coli]	239	1.60E-44
EF121-2	gi\|1773162	UDP-sugar hydrolase precursor [Escherichia coli] >gi\|1786687	239	1.60E-44
EF121-2	gi\|47950	precursor polypeptide (AA −25 to 525) [Salmonella	229	2.10E-41
		typhimurium]
EF121-2	gi\|747913	2′,3′-cyclic-nucleotide 2′-phosphodiesterase [Yersinia	115	4.70E-36
EF121-2	gi\|62772	5′-nucleotidase [Discopyge ommata] >pir\|S19564\|S19564 5′-	137	5.80E-35
		nucleotidase
EF121-2	gi\|1573573	2′,3′-cyclic-nucleotide 2′-phosphodiesterase (cpdB)	114	8.90E-34
		[Haemophilus
EF121-2	gi\|537054	2′,3′-cyclic-nucleotide 2′-phosphodiesterase [Escherichia coli]	110	1.10E-31
EF121-2	bbs\|135915	5′-nucleotidase=glycosylphosphatidylinositol-anchored protein	128	7.70E-29
		{EC
EF121-2	gi\|1737443	5′-nucleotidase [Boophilus microplus]	104	1.60E-28
EF121-2	gi\|202551	5′-nucleotidase precursor (EC 3.1.3.5) [Rattus norvegicus]	138	6.10E-28
EF121-2	gi\|349783	ecto-5′-nucleotidase [Mus musculus] >pir\|JC2001\|JC2001	136	1.10E-27
EF121-2	gi\|23897	5′-nucleotidase [Homo sapiens] >pir\|S10032\|S11032 5′-	133	1.60E-27
		nucleotidase (EC
EF122-2	gi\|2626826	YfkN [Bacillus subtilis] >gnl\|PID\|e1182774 similar to	143	1.30E-96
EF122-2	gi\|2313187	(AE000532) 2′,3′-cyclic-nucleotide 2′-phosphodiesterase (cpdB)	413	2.60E-82
EF122-2	gi\|48453	5′-nucleotidase [Vibrio parahaemolyticus] >gnl\|PID\|d1001218	279	8.50E-47
EF122-2	gi\|757842	UDP-sugar hydrolase [Escherichia coli]	239	1.60E-44
EF122-2	gi\|1773162	UDP-sugar hydrolase precursor [Escherichia coli] >gi\|1786687	239	1.60E-44
EF122-2	gi\|47950	precursor polypeptide (AA −25 to 525) [Salmonella	229	2.10E-41
		typhimurium]
EF122-2	gi\|747913	2′,3′-cyclic-nucleotide 2′-phosphodiesterase [Yersinia	115	4.70E-36
EF122-2	gi\|62772	5′-nucleotidase [Discopyge ommata] >pir\|S19564\|S19564 5′-	137	5.80E-35
		nucleotidase
EF122-2	gi\|1573573	2′,3′-cyclic-nucleotide 2′-phosphodiesterase (cpdB)	114	8.90E-34
		[Haemophilus
EF122-2	gi\|537054	2′,3′-cyclic-nucleotide 2′-phosphodiesterase [Escherichia coli]	110	1.10E-31
EF122-2	bbs\|135915	5′-nucleotidase=glycosylphosphatidylinositol-anchored protein	128	7.70E-29
		{EC
EF122-2	gi\|1737443	5′-nucleotidase [Boophilus microplus]	104	1.60E-28
EF122-2	gi\|202551	5′-nucleotidase precursor (EC 3.1.3.5) [Rattus norvegicus]	138	6.10E-28
EF122-2	gi\|349783	ecto-5′-nucleotidase [Mus musculus] >pir\|C2001\|JC2001	136	1.10E-27
EF122-2	gi\|23897	5′-nucleotidase [Homo sapiens] >pir\|S11032\|S11032 5′-	133	1.60E-27
		nucleotidase (EC
EF129-2	gi\|43334	P54 protein [Enterococcus faecium] >pir\|S05542\|S05542	630	9.40E-79
		hypothetical
EF129-2	gi\|512521	usp 45 gene product [Lactococcus lactis] >pir\|JN0097\|JN0097	374	1.30E-42
		secreted
EF129-2	gi\|149525	secreted protein [Lactococcus lactis]	371	3.60E-42
EF129-2	gnl\|PlD\|e313022	hypothetical protein [Bacillus subtilis] >gnl\|PID\|e1186168	317	2.30E-33
EF130-2	gi\|488339	alpha-amylase [unidentified cloning vector]	621	6.70E-81
EF130-2	gi\|488336	ORF [unidentified cloning vector]	242	8.00E-27
EF130-2	bbs\|112518	alpha-amylase {N-terminal region} [Artificial sequence, Peptide	237	4.80E-26
EF130-2	gnl\|PlD\|e289144	ywpE [Bacillus subtilis] >gnl\|PID\|e1184540 ywpE [Bacillus	129	5.40E-11
EF131-2	gnl\|PID\|e118528	penicillin-binding protein [Bacillus subtilis]	277	7.40E-43
EF131-2	gi\|488330	alpha-amylase [unidentified cloning vector]	280	1.30E-31
EF131-2	gi\|509249	No definition line found [Lactobacillus plantarum]	274	1.10E-30
EF131-2	gnl\|PID\|d102491	(AB009635) Fmt [Staphylococcus aureus]	170	5.60E-20
EF131-2	gi\|515050	DD-peptidase precursor [Streptomyces lividans]	131	2.30E-14
		>pir\|S48220\|S48220
EF131-2	gi\|153448	serine DD-peptidase [Streptomyces lividans]	131	1.20E-12
EF132-2	gi\|153826	adhesin B [Streptococcus sanguis] >pir\|A43583\|A43583 adhesin	1257	2.30E-166
		B
EF132-2	gi\|1184932	ScbA [Streptococcus crista]	1248	3.70E-165
EF132-2	gi\|310633	adhesin [Streptococcus gordonii]	1247	5.10E-165
EF132-2	gi\|393269	adhesion protein [Streptococcus pneumoniae]	1204	3.40E-163
EF132-2	gi\|1575030	surface adhesin A precursor [Streptococcus pneumoniae]	1220	2.40E-161
EF132-2	gi\|153834	adhesin specific for salivary pellicle of dental surfaces	1203	4.80E-159
EF132-2	gi\|1117994	surface antigen A variant precursor [Streptococcus pneumoniae]	1191	2.00E-157
EF132-2	gi\|493017	endocarditis specific antigen [Enterococcus faecalis]	931	3.70E-122
EF132-2	gnl\|PID\|e255529	lipoprotein [Staphylococcus epidermidis]	453	3.20E-92
EF132-2	gi\|1245464	YfeA [Yersinia pestis] >gi\|1245464 YfeA [Yersinia pestis]	364	3.60E-64
EF132-2	gi\|1573330	adhesin B precursor (fimA) [Haemophilus influenzae]	349	3.50E-63
EF132-2	gi\|755075	periplasmic-binding protein [Synechocystis sp.]	326	6.80E-62
		>gnl\|PID\|d1018652 Mn
EF132-2	gnl\|PID\|e118595	similar to ABC transporter (membrane protein) [Bacillus	174	3.10E-32
EF132-2	gi\|1777933	TroA [Treponema pallidum]	171	3.40E-32
EF132-2	gi\|790546	Tromp1 [Treponema pallidum]	171	5.10E-32

	Derwent		BLAST	BLAST
Query	Access. No.	Derwent Gene Description	Score	P-Value

EF003-2	W20909	H. pylori outer membrane protein 14ge10705orf5.	268	4.20E-39
EF003-2	W20166	Helicobacter pylori outer membrane protein, 16225006.aa.	241	3.00E-27
EF006-2	W20909	H. pylori outer membrane protein 14ge10705orf5.	283	1.20E-48
EF006-2	W20166	Helicobacter pylori outer membrane protein, 16225006.aa.	266	1.10E-30
EF008-2	R37495	Pneumococcal fimbrial protein A.	967	1.20E-127
EF008-2	W26367	Staphylococcus aureus saliva binding protein.	467	7.50E-100
EF008-2	R79722	ROM precursor TROMP1.	181	8.00E-36
EF008-2	W22134	Treponema pallidum rare outer membrane protein (TROMP-1).	181	8.00E-36
EF009-2	W20909	H. pylori outer membrane protein 14ge10705orf5.	319	1.40E-53
EF009-2	W20166	Helicobacter pylori outer membrane protein, 16225006.aa.	278	2.50E-32
EF012-2	R48035	Hyaluronic acid synthase of Streptococcus equisimilis.	227	3.20E-69
EF014-2	W14070	S. thermophilus exopolysaccharide biosynthesis protein EpsR.	103	5.90E-19
EF014-2	W22169	S. thermophilus exopolysaccharide synthesis operon epsA gene	103	7.30E-18
		product.
EF016-2	W15799	Adherence factor 104R of Lactobacillus fermentum.	157	9.60E-22
EF016-2	W15793	Adherence factor consensus sequence.	103	1.00E-11
EF017-2	R48035	Hyaluronic acid synthase of Streptococcus equisimilis.	241	8.90E-71
EF021-2	R31013	P39-alpha.	141	1.60E-19
EF021-2	R33280	P39-beta.	134	7.00E-14
EF022-2	R48035	Hyaluronic acid synthase of Streptococcus equisimilis.	324	2.20E-65
EF023-2	R48035	Hyaluronic acid synthase of Streptococcus equisimilis.	155	9.90E-33
EF023-2	R70152	Streptococcus pneumoniae strain SPRU98 PlpA.	125	5.90E-17
EF027-2	R48035	Hyaluronic acid synthase of Streptococcus equisimilis.	233	2.20E-34
EF028-2	W17830	Thermophilic alkaline phosphatase.	202	7.70E-59
EF028-2	W11568	E. coli alkaline phosphatase mutant D153H/Q329A.	182	7.90E-56
EF028-2	W11570	E. coli alkaline phosphatase mutant D153H/K328H/Q329A.	182	7.90E-56
EF028-2	W26300	E. coli alkaline phosphatase mutant	182	1.10E-55
		D153H/K328H/Q329A/D330H.
EF028-2	W11565	E. coli alkaline phosphatase mutant D153H/K328H/D330A.	182	3.10E-55
EF028-2	W11557	E. coli alkaline phosphatase mutant D153H/D330N.	182	4.30E-55
EF028-2	W11561	E. coli alkaline phosphatase mutant D153H/D330A.	182	4.30E-55
EF028-2	W11555	E. coli alkaline phosphatase mutant D153H/K328H/D330N.	182	4.70E-55
EF028-2	W11566	E. coli alkaline phosphatase mutant D153H/K328H/D330L.	182	1.20E-54
EF028-2	W11569	E. coli alkaline phosphatase mutant K328H/Q329A.	180	1.70E-54
EF028-2	W11562	E. coli alkaline phosphatase mutant D153H/D330L.	182	1.70E-54
EF028-2	R26980	Fv(FRP5)-phoA recombinant antibody.	174	1.90E-54
EF028-2	W11567	E. coli alkaline phosphatase mutant Q329A.	179	2.30E-54
EF028-2	W11558	E. coli alkaline phosphatase mutant K328H/D330N.	176	6.40E-54
EF028-2	W11563	E. coli alkaline phosphatase mutant K328H/D330A.	176	6.40E-54
EF029-2	R10044	Plasmid pOW360 encoded Human Growth Hormone (HGH) -	320	3.50E-40
		nuclease A
EF029-2	R10041	Plasmid pOW350 nuclease A product.	320	4.30E-40
EF029-2	R73997	Staphylococcus aureus (Foggi) nuclease signal and mature	320	5.60E-40
		sequences.
EF029-2	R10043	Plasmid pOW360 encoding Human Growth Hormone (HGH) -	320	2.90E-38
		nuclease
EF030-2	R48035	Hyaluronic acid synthase of Streptococcus equisimilis.	277	6.10E-47
EF040-2	R59077	2-5A-dependent RNA-ase.	105	1.90E-18
EF040-2	W12703	Mouse 2-5A-dependent RNase.	105	1.90E-18
EF040-2	R82661	Partial murine 2-5A-dependent RNase.	105	1.90E-18
EF041-2	R48035	Hyaluronic acid synthase of Streptococcus equisimilis.	225	6.30E-26
EF054-2	R26042	P. yoelii SSP2 antigen.	286	8.00E-34
EF054-2	R85782	Group B Streptococcal mutant beta antigen without IgA binding	232	3.30E-24
		domain.
EF054-2	R85781	Group B Streptococcal wild-type beta antigen.	232	5.20E-24
EF054-2	P91941	Sequence of preprospasmolysin.	204	3.10E-19
EF054-2	W32519	Collagen-like polypeptide SEQ ID NO:2.	180	7.50E-18
EF054-2	W12324	Silver halide emulsion protein monomeric repeat unit #2.	180	7.50E-18
EF054-2	W32522	Collagen-like polypeptide SEQ ID NO:5.	192	1.60E-17
EF054-2	W12327	Silver halide emulsion protein monomeric repeat unit #5.	192	1.60E-17
EF054-2	W32520	Collagen-like polypeptide SEQ ID NO:3.	189	2.40E-17
EF054-2	W32532	Collagen-like polypeptide SEQ ID NO:15.	189	2.40E-17
EF054-2	W12325	Silver halide emulsion protein monomeric repeat unit #3.	189	2.40E-17
EF054-2	W12337	Silver halide emulsion protein monomeric repeat unit #15.	189	2.40E-17
EF054-2	W12341	Silver halide emulsion FLAG(RTM)-tagged protein #2.	189	2.60E-17
EF054-2	W02098	S. mutans antigen I/II.	161	5.40E-15
EF054-2	W02096	S. mutans antigen I/II fragment (aa803-1114).	161	1.90E-13
EF059-2	R26042	P. yoelii SSP2 antigen.	344	1.90E-39
EF059-2	R85782	Group B Streptococcal mutant beta antigen without IgA binding	232	1.10E-26
		domain.
EF059-2	R85781	Group B Streptococcal wild-type beta antigen.	232	1.70E-26
EF059-2	P91941	Sequence of preprospasmolysin.	200	1.50E-18
EF059-2	P60570	Sequence of the Falciparum Interspersed Repeat Antigen	186	4.60E-18
EF059-2	W02096	S. mutans antigen I/II fragment (aa803-1114).	167	8.20E-16
EF059-2	W02098	S. mutans antigen I/II.	167	4.90E-15
EF059-2	R79625	Endocarditis specific antigen region.	147	4.40E-12
EF059-2	R26049	MSF precursor.	143	1.30E-11
EF059-2	R28150	Sugar beet chitinase 1.	148	1.70E-11
EF059-2	R26842	Protease from S. Aureus ATCC12600.	147	2.10E-11
EF059-2	R79643	Immunodominant antigen of Streptococcus sobrinus.	151	2.10E-11
EF059-2	W07539	Collagen like protein (CLP).	146	3.00E-11
EF061-2	R26042	P. yoelii SSP2 antigen.	241	1.70E-25
EF061-2	P60570	Sequence of the Falciparum Interspersed Repeat Antigen	199	1.60E-18
EF061-2	R85782	Group B Streptococcal mutant beta antigen without IgA binding	153	2.40E-14
		domain.
EF061-2	R85781	Group B Streptococcal wild-type beta antigen.	153	3.60E-14
EF061-2	P91941	Sequence of preprospasmolysin.	163	9.70E-14
EF061-2	P83194	Sequence of a bioadhesive precursor protein encoded by cDNA	156	7.90E-13
		clone
EF061-2	R28150	Sugar beet chitinase 1.	156	9.10E-13
EF061-2	W02096	S. mutans antigen I/II fragment (aa803-1114).	148	1.20E-12
EF061-2	P82971	Bioadhesive precursor protein from cDNA 52.	148	9.70E-12
EF061-2	W02098	S. mutans antigen I/II.	148	1.50E-11
EF062-2	W02098	S. mutans antigen I/II.	107	1.20E-36
EF062-2	R79643	Immunodominant antigen of Streptococcus sobrinus.	132	3.00E-36
EF063-2	W02098	S. mutans antigen I/II.	107	1.20E-36
EF063-2	R79643	Immunodominant antigen of Streptococcus sobrinus.	132	3.00E-36
EF064-2	W02098	S. mutans antigen I/II.	107	1.20E-36
EF064-2	R79643	Immunodominant antigen of Streptococcus sobrinus.	132	3.00E-36
EF071-2	R85294	Phage R1-t LytR lysin.	127	3.70E-38
EF071-2	R91515	Listeria phage lysin PLY511.	273	4.70E-37
EF075-2	W14070	S. thermophilus exopolysaccharide biosynthesis protein EpsR.	239	4.20E-36
EF075-2	W22169	S. thermophilus exopolysaccharide synthesis operon epsA gene	239	4.00E-34
		product.
EF077-2	R97280	Helicobacter-specific ATPase 439.	258	4.10E-74
EF077-2	R48036	Mycobacterium BCG immunogen.	192	2.20E-67
EF077-2	W06712	Helicobacter-specific ATPase 948 (ORF-4).	220	2.50E-67
EF077-2	R70419	Rat homologue of human Wilson disease gene ATP7B.	186	9.80E-54
EF077-2	R72343	Wilson disease protein ATP7B.	176	6.70E-40
EF077-2	R06376	Product of the ssc 1 gene.	166	3.10E-28
EF077-2	R75396	Flea sodium pump alpha subunit.	146	2.40E-25
EF077-2	W20891	H. pylori transporter protein, 14ce20219orf1.	156	8.60E-14
EF078-2	R56667	Bacteroides fragilis RprX regulatory response protein.	148	8.30E-18
EF078-2	R74630	Tomato TGETR1 ethylene response protein.	130	7.80E-13
EF078-2	R69849	Ethylene response (ETR) gene product.	128	1.70E-11
EF078-2	R69850	Ethylene response (ETR) mutant protein etr1-1.	128	1.70E-11
EF078-2	R69851	Ethylene response (ETR) mutant protein etr1-2.	128	1.70E-11
EF078-2	R69852	Ethylene response (ETR) mutant protein etr1-3.	128	1.70E-11
EF078-2	R69853	Ethylene response (ETR) mutant protein etr1-4.	128	1.70E-11
EF078-2	R24296	Regulatory protein VanS involved in glycopeptide resistance.	142	2.70E-11
EF081-2	R27253	Penicillin binding protein PBP2A-epi.	101	4.70E-16
EF081-2	R27256	Penicillin binding protein PBP2A-27R.	101	6.00E-15
EF081-2	R27257	Penicillin binding protein derivative #1.	101	6.20E-15
EF081-2	R27258	Penicillin binding protein derivative #2.	101	6.20E-15
EF081-2	R27259	Penicillin binding protein derivative #3.	101	6.20E-15
EF081-2	R27260	Penicillin binding protein derivative #4.	101	6.20E-15
EF081-2	R27261	Penicillin binding protein derivative #5.	101	6.20E-15
EF081-2	R27263	Penicillin binding protein derivative #7.	101	6.20E-15
EF081-2	R27264	Penicillin binding protein derivative #8.	101	6.20E-15
EF081-2	R27262	Penicillin binding protein derivative #6.	101	6.50E-15
EF081-2	R30845	Sequence encoded by the mec A gene.	101	6.90E-15
EF081-2	R27255	Penicillin binding protein PBP2A-27R.	101	6.90E-15
EF081-2	R31216	Penicillin binding protein PBP2A-27R.	101	7.00E-15
EF110-2	R91042	V8 mature protease (aa1-213).	106	6.60E-16
EF110-2	R91043	V8 mature protease (aa1-214).	106	7.20E-16
EF110-2	R91044	V8 mature protease (aa1-215).	106	7.80E-16
EF110-2	R26842	Protease from S. Aureus ATCC12600.	106	6.70E-15
EF110-2	R29644	Protease from S. Aureus.	106	1.20E-14
EF110-2	W22218	Protein encoded by pV8RPT(−) construct.	106	7.60E-14
EF110-2	R91033	Beta-galactosidase-V8 protease fusion protein.	106	7.60E-14
EF110-2	R91034	Beta-galactosidase-V8 protease fusion protein.	106	1.70E-13
EF110-2	W22219	Protein encoded by pV8D construct.	106	7.60E-13
EF110-2	R91035	Recombinant V8 protease V8D fusion protein.	106	7.60E-13
EF110-2	W22220	Protein encoded by pV8F construct.	106	7.90E-13
EF129-2	R14530	Usp45 protein.	374	2.40E-43
EF129-2	R14150	MSP encoded by pUCRS (DSM 5803).	372	4.70E-43
EF131-2	R37495	Pneumococcal fimbrial protein A.	1185	6.80E-163
EF131-2	W26367	Staphylococcus aureus saliva binding protein.	418	3.70E-85
EF131-2	R79722	ROM precursor TROMP1.	171	9.00E-31
EF131-2	W22134	Treponema pallidum rare outer membrane protein (TROMP-1).	171	9.00E-31

TABLE 3


Conservative Amino Acid Substitutions.

	Aromatic	Phenylalanine
		Tryptophan
		Tyrosine
	Hydrophobic	Leucine
		Isoleucine
		Valine
	Polar	Glutamine
		Asparagine
	Basic	Arginine
		Lysine
		Histidine
	Acidic	Aspartic Acid
		Glutamic Acid
	Small	Alanine
		Serine
		Threonine
		Methionine
		Glycine

TABLE 4


Residues Comprising Antigenic Epitope-Bearing Portion.

EF001-2	from about Asp-150 to about Lys-152, from about Ser-256 to
	about Tyr-259, from about Lys-360 to about Lys-363, from
	about Asn-406 to about Asp-408.
EF002-2	from about Asp-80 to about Asp-83, from about Asp-281 to
	about Gly-283.
EF003-2	from about Asn-263 to about Gly-266.
EF004-2	from about Asn-23 to about Asn-26, from about Lys-83 to
	about Ser-87, from about Tyr-154 to about Asp-159.
EF005-2	from about Lys-249 to about Glu-252.
EF006-2	from about Gly-23 to about Asp-28.
EF008-2	from about Thr-92 to about Gly-94, from about Pro-161 to
	about Asp-165, from about Gly-287 to about Thr-289.
EF010-2	from about Pro-129 to about Asn-131.
EF012-2	from about Asp-77 to about Asp-79, from about Asp-94 to
	about Lys-98, from about Asp-256 to about Thr-258, from
	about Glu-461 to about Asn-468.
EF013-2	from about Thr-30 to about Asp-32, from about Glu-73 to
	about Ala-75, from about Gln-164 to about Asn-166, from
	about Lys-193 to about Gly-195.
EF014-2	from about Ser-203 to about Asp-206, from about Gln-314
	to about Gly-316
EF015-2	from about Pro-66 to about Gly-69.
EF016-2	from about Lys-236 to about Asn-239.
EF017-2	from about Ser-90 to about Gly-93, from about Thr-197 to
	about Lys-199, from about Lys-230 to about Asn-233, from
	about Ser-428 to about Gly-431.
EF018-2	from about Lys-159 to about Tyr-161, from about Asn-165
	to about Ser-167, from about Asn-250 to about Arg-256,
	from about Asn-392 to about Gly-395, from about Lys-416
	to about Tyr-418, from about Asn-428 to about Arg-430.
EF019-2	from about Arg-209 to about Ser-211, from about Lys-287
	to about Ser-290.
EF020-2	from about Lys-57 to about Asn-62.
EF021-2	from about Ser-33 to about Gly-35, from about Glu-77 to
	about Gly-81, from about Asp-139 to about Lys-141, from
	about Glu-255 to about Ser-258, from about Gln-271 to
	about Tyr-277.
EF023-2	from about Lys-232 to about Asp-234, from about Arg-304
	to about Gly-306, from about Thr-453 to about Arg-456,
	from about Ser-478 to about Thr-480.
EF025-2	from about Arg-183 to about Asp-185.
EF026-2	from about Ser-25 to about Asp-30, from about Asp-90 to
	about Asp-94, from about Gln-107 to about Asn-110.
EF027-2	from about Gln-72 to about Lys-74, from about Lys-229
	to about Asp-231.
EF028-2	from about Asp-186 to about Gln-188.
EF029-2	from about Asp-118 to about Lys-122, from about Asp-124
	to about Tyr-126.
EF031-2	from about Glu-30 to about Gly-33.
EF034-2	from about Glu-25 to about Gly-27, from about Glu-75 to
	about Thr-77.
EF36-2	from about Gln-177 to about Ser-179.
EF037-2	from about Ser-25 to about Asp-30, from about Asp-90 to
	about Asp-94, from about Gln-107 to about Asn-110.
EF038-2	from about Asn-77 to about Lys-79, from about Tyr-88 to
	about Asn-92.
EF040-2	from about Lys-167 to about Gly-172, from about Lys-240
	to about Asn-242.
EF044-2	from about Arg-192 to about Gly-194, from about Asn-200
	to about Asn-203.
EF045-2	from about Asp-159 to about Asn-161, from about His-172
	to about Gly-174, from about Tyr-261 to about Gly-264,
	from about Lys-305 to about Glu-308.
EF046-2	from about Ser-18 to about Gly-23, from about Gln-41 to
	about Ser-47, from about Thr-76 to about Asp-78.
EF047-2	from about Asn-28 to about Asp-30, from about Asp-273
	to about Asn-277.
EF048-2	from about Asp-138 to about Lys-141, from about Asp-152
	to about Gly-154.
EF051-2	from about Asp-73 to about Gly-76.
EF053-2	from about Ser-79 to about Gly-82.
EF055-2	from about Asp-26 to about Gly-28, from about Gln-67 to
	about Asp-69, from about Arg-71 to about Gly-74, from
	about Arg-87 to about Gly-89.
EF056-2	from about Arg-71 to about Gly-74, from about Arg-87 to
	about Gly-89.
EF058-2	from about Lys-129 to about Gly-133, from about Gln-571
	to about Tyr-573, from about Pro-586 to about Gly-591.
EF065-2	from about Ser-236 to about Tyr-239, from about Asp-350
	to about Gly-352, from about Lys-415 to about Asn-418,
	from about Arg-446 to about Asp-448, from about Asn-489
	to about Lys-491, from about Ser-516 to about Asp-518,
	from about Glu-639 to about Lys-642.
EF066-2	from about Ser-236 to about Tyr-239, from about Asp-350
	to about Gly-352, from about Lys-415 to about Asn-418,
	from about Arg-446 to about Asp-448, from about Asn-489
	to about Lys-491, from about Ser-516 to about Asp-518,
	from about Glu-639 to about Lys-642.
EF067-2	from about Ser-236 to about Tyr-239, from about Asp-350
	to about Gly-352, from about Lys-415 to about Asn-418,
	from about Arg-446 to about Asp-448, from about Asn-489
	to about Lys-491, from about Ser-516 to about Asp-518,
	from about Glu-639 to about Lys-642.
EF073-2	from about Met-98 to about Arg-100, from about Arg-110
	to about Asp-112.
EF074-2	from about Ser-53 to about Tyr-59, from about Ser-86 to
	about Gly-88, from about Pro-97 to about Gln-100, from
	about Gln-230 to about Gly-232.
EF076-2	from about Asn-38 to about Tyr-40, from about Asp-48 to
	about Asn-53, from about Lys-79 to about Gly-81.
EF077-2	from about Arg-411 to about Gly-413.
EF078-2	from about Thr-294 to about Gly-296, from about Asp-366
	to about Gln-368, from about Glu-524 to about Gly-526.
EF080-2	from about Glu-164 to about Gly-166, from about Ser-206
	to about Tyr-208, from about Lys-239 to about Gly-243.
EF081-2	from about Asn-7 to about Ser-11, from about Lys-77 to
	about Tyr-80, from about Lys-112 to about Asn-114,
	from about Gly-162 to about Asp-164, from about Arg-181
	to about Gly-183.
EF083-2	from about Gln-38 to about Arg-40.
EF084-2	from about Lys-140 to about Asp-142, from about Gly-164
	to about Arg-166, from about Arg-262 to about Gly-264.
EF085-2	from about Asn-95 to about Asp-97, from about Arg-112
	to about Asp-114, from about Asp-258 to about Ser-260,
	from about Arg-401 to about Ser-403.
EF086-2	from about Pro-112 to about Gly-115, from about Ser-222
	to about Ser-224, from about Asn-296 to about Gly-299,
	from about Thr-346 to about Lys-348, from about Asp-428
	to about Ser-432.
EF087-2	from about Pro-112 to about Gly-115, from about Ser-222
	to about Ser-224, from about Asn-296 to about Gly-299,
	from about Thr-346 to about Lys-348, from about Asp-428
	to about Ser-432.
EF088-2	from about Pro-112 to about Gly-115, from about Ser-222
	to about Ser-224, from about Asn-296 to about Gly-299,
	from about Thr-346 to about Lys-348, from about Asp-428
	to about Ser-432.
EF090-2	from about Arg-2 to about Arg-5.
EF091-2	from about Gln-40 to about Asp-43.
EF093-2	from about Lys-95 to about Gly-97.
EF094-2	from about Asp-314 to about Asp-316.
EF095-2	from about Ser-328 to about Thr-330, from about Asp-359
	to about Asp-363, from about Glu-637 to about Gly-639,
	from about Asn-744 to about Gly-746.
EF096-2	from about Pro-128 to about Asn-130, from about Ser-193
	to about Asp-196.
EF097-2	from about Val-357 to about Gly-359.
EF099-2	from about Glu-44 to about Asp-47, from about Lys-154
	to about Gly-156, from about Asn-286 to about Asp-289.
EF101-2	from about Lys-40 to about Asp-42, from about Pro-255
	to about Asn-258, from about Lys-288 to about Gly-290.
EF102-2	from about Asp-314 to about Asp-316.
EF103-2	from about Asn-46 to about Gly-48.
EF104-2	from about Pro-232 to about Lys-237, from about Ala-362
	to about Asn-366, from about Ser-421 to about Gly-423,
	from about Lys-488 to about Ser-490, from about Asp-550
	to about Asn-552, from about Pro-637 to about Lys-640,
	from about Asp-727 to about Gly-729, from about Asn-751
	to about Ser-754, from about Lys-771 to about Asn-774,
	from about Ile-835 to about Asn-837, from about Pro-851
	to about Gly-853.
EF105-2	from about Ser-40 to about Gly-43, from about Asn-94 to
	about Gln-97, from about Gln-220 to about Gly-222, from
	about Asn-263 to about Gly-265.
EF106-2	from about Asp-72 to about Gly-75, from about Thr-274
	to about Asp-277, from about Asn-310 to about Arg-313.
EF107-2	from about Thr-155 to about Asn-157, from about Thr-189
	to about Asp-191, from about Arg-270 to about Gly-272,
	from about Thr-330 to about Lys-335, from about Asp-365
	to about Asp-368, from about Pro-451 to about Asp-453,
	from about Gly-485 to about Thr-488.
EF108-2	from about Lys-142 to about Trp-145, from about Thr-147
	to about Tyr-150, from about Arg-212 to about Gly-214,
	from about Ser-248 to about Asp-251, from about Asp-384
	to about Asp-387, from about Pro-481 to about Arg-483,
	from about Lys-491 to about Gly-494, from about Thr-619
	to about Gly-624, from about Asp-656 to about Asp-659,
	from about Lys-717 to about Asn-721, from about Ser-822
	to about Gly-824, from about Tyr-1137 to about Thr-1141.
EF110-2	from about Pro-123 to about Gly-127, from about Thr-223
	to about Gly-225.
EF111-2	from about Lys-207 to about Asn-209, from about Asp-245
	to about Asn-248, from about Lys-396 to about Asp-398,
	from about Glu-429 to about Ser-432, from about Thr-470
	to about His-474.
EF119-2	from about Asp-90 to about Asn-92, from about Gln-142
	to about Gly-144.
EF121-2	from about Asn-159 to about Asp-161, from about Asn-351
	to about Lys-353, from about Pro-658 to about Gly-660,
	from about Lys-786 to about Ser-789.
EF122-2	from about Asn-159 to about Asp-161, from about Asn-351
	to about Lys-353, from about Pro-658 to about Gly-660,
	from about Lys-786 to about Ser-789.
EF123-2	from about Asn-331 to about Arg-336, from about Asp-634
	to about Gly-636, from about Glu-780 to about Ser-782,
	from about Tyr-909 to about Asn-911, from about Lys-939
	to about Glu-942, from about Asp-1074 to about Gly-1076,
	from about Asp-1367 to about Gly-1369, from about
	Pro-1433 to about Lys-1435, from about Gly-1516 to about
	Asp-1518, from about Lys-1656 to about Asp-1660, from
	about Lys-1860 to about Gln-1863, from about Ser-1916
	to about Gln-1919, from about Pro-1940 to about Gly-1942.
EF124-2	from about Asn-331 to about Arg-336, from about Asp-634
	to about Gly-636, from about Glu-780 to about Ser-782,
	from about Tyr-909 to about Asn-911, from about Lys-939
	to about Glu-942, from about Asp-1074 to about Gly-1076,
	from about Asp-1367 to about Gly-1369, from about Pro-1433
	to about Lys-1435, from about Gly-1516 to about Asp-1518,
	from about Lys-1656 to about Asp-1660, from about
	Lys-1860 to about Gln-1863, from about Ser-1916 to about
	Gln-1919, from about Pro-1940 to about Gly-1942.
EF125-2	from about Asn-331 to about Arg-336, from about Asp-634
	to about Gly-636, from about Glu-780 to about Ser-782, from
	about Tyr-909 to about Asn-911, from about Lys-939 to
	about Glu-942, from about Asp-1074 to about Gly-1076, from
	about Asp-1367 to about Gly-1369, from about Pro-1433 to
	about Lys-1435, from about Gly-1516 to about Asp-1518,
	from about Lys-1656 to about Asp-1660, from about
	Lys-1860 to about Gln-1863, from about Ser-1916 to about
	Gln-1919, from about Pro-1940 to about Gly-1942.
EF126-2	from about Ser-236 to about Tyr-239, from about Asp-350 to
	about Gly-352, from about Lys-415 to about Asn-418, from
	about Arg-446 to about Asp-448, from about Asn-489 to
	about Lys-491, from about Ser-516 to about Asp-518, from
	about Glu-639 to about Lys-642.
EF127-2	from about Ser-236 to about Tyr-239, from about Asp-350 to
	about Gly-352, from about Lys-415 to about Asn-418, from
	about Arg-446 to about Asp-448, from about Asn-489 to
	about Lys-491, from about Ser-516 to about Asp-518, from
	about Glu-639 to about Lys-642.
EF128-2	from about Ser-236 to about Tyr-239, from about Asp-350
	to about Gly-352, from about Lys-415 to about Asn-418,
	from about Arg-446 to about Asp-448, from about Asn-489
	to about Lys-491, from about Ser-516 to about Asp-518,
	from about Glu-639 to about Lys-642.
EF129-2	from about Asn-300 to about Gly-302, from about Ser-316
	to about Gly-319, from about Asn-385 to about His-387
EF131-2	from about Lys-201 to about Tyr-204, from about Glu-263
	to about Ser-266.
EF132-2	from about Thr-26 to about Ser-28.

[0271]

0

SEQUENCE LISTING

The patent application contains a lengthy “Sequence Listing” section. A copy of the “Sequence Listing” is available in electronic form from the USPTO

web site (http://seqdata.uspto.gov/sequence.html?DocID=20020045737). An electronic copy of the “Sequence Listing” will also be available from the

USPTO upon request and payment of the fee set forth in 37 CFR 1.19(b)(3).

Claims

What is claimed is:

1. An isolated nucleic acid molecule comprising a polynucleotide having a nucleotide sequence selected from the group consisting of:

(a) a nucleotide sequence encoding any one of the amino acid sequences of the polypeptides shown in Table 1; or

(b) a nucleotide sequence complementary to any one of the nucleotide sequences in (a).

(c) a nucleotide sequence at least 95% identical to any one of the nucleotide sequences shown in Table 1; or,

(d) a nucleotide sequence at least 95% identical to a nucleotide sequence complementary to any one of the nucleotide sequences shown in Table 1.

2. An isolated nucleic acid molecule of claim 1 comprising a polynucleotide which hybridizes under stringent hybridization conditions to a polynucleotide having a nucleotide sequence identical to a nucleotide sequence in (a) or (b) of claim 1.

3. An isolated nucleic acid molecule of claim 1 comprising a polynucleotide which encodes an epitope-bearing portion of a polypeptide in (a) of claim 1.

4. The isolated nucleic acid molecule of claim 3, wherein said epitope-bearing portion of a polypeptide comprises an amino acid sequence listed in Table 4.

5. A method for making a recombinant vector comprising inserting an isolated nucleic acid molecule of claim 1 into a vector.

6. A recombinant vector produced by the method of claim 5.

7. A host cell comprising the vector of claim 6.

8. A method of producing a polypeptide comprising:

(a) growing the host cell of claim 7 such that the protein is expressed by the cell; and

(b) recovering the expressed polypeptide.

9. An isolated polypeptide comprising a polypeptide selected from the group consisting of:

(a) a polypeptide consisting of one of the complete amino acid sequences of Table 1;

(b) a polypeptide consisting of one the complete amino acid sequences of Table 1 except the N-terminal residue;

(c) a fragment of the polypeptide of (a) having biological activity; and

(d) a fragment of the polypeptide of (a) which binds to an antibody specific for the polypeptide of (a).

10. An isolated antibody specific for the polypeptide of claim 9.

11. A polypeptide produced according to the method of claim 8.

12. An isolated polypeptide comprising an amino acid sequence at least 95% identical to a sequence selected from the group consisting of an amino acid sequence of any one of the polypeptides in Table 1.

13. An isolated polypeptide antigen comprising an amino acid sequence of an E. faecalis epitope shown in Table 4.

14. An isolated nucleic acid molecule comprising a polynucleotide with a nucleotide sequence encoding a polypeptide of claim 9.

15. A hybridoma which produces an antibody of claim 10.

16. A vaccine, comprising:

(1) one or more E. faecalis polypeptides selected from the group consisting of a polypeptide of claim 9; and

(2) a pharmaceutically acceptable diluent, carrier, or excipient; wherein said polypeptide is present, in an amount effective to elicit protective antibodies in an animal to a member of the Enterococcus genus.

17. A method of preventing or attenuating an infection caused by a member of the Enterococcus genus in an animal, comprising administering to said animal a polypeptide of claim 9, wherein said polypeptide is administered in an amount effective to prevent or attenuate said infection.

18. A method of detecting Enterococcus nucleic acids in a biological sample comprising:

(a) contacting the sample with one or more nucleic acids of claim 1, under conditions such that hybridization occurs, and

(b) detecting hybridization of said nucleic acids to the one or more Enterococcus nucleic acid sequences present in the biological sample.

19. A method of detecting Enterococcus nucleic acids in a biological sample obtained from an animal, comprising:

(a) amplifying one or more Enterococcus nucleic acid sequences in said sample using polymerase chain reaction, and

(b) detecting said amplified Enterococcus nucleic acid.

20. A kit for detecting Enterococcus antibodies in a biological sample obtained from an animal, comprising

(a) a polypeptide of claim 9 attached to a solid support; and

(b) detecting means.

21. A method of detecting Enterococcus antibodies in a biological sample obtained from an animal, comprising

(a) contacting the sample with a polypeptide of claim 9; and

(b) detecting antibody-antigen complexes.