UA71938C2 - BENZYOXAZOLES AND PHENONES AS a2-ANTAGONISTS - Google Patents

BENZYOXAZOLES AND PHENONES AS a2-ANTAGONISTS Download PDF

Info

Publication number: UA71938C2
Authority: UA; Ukraine
Prior art keywords: formula; compounds; mixture; equals; acid
Prior art date: 1998-12-21

Application number

UA2001064352A

Other languages

English (en)

Ukrainian (uk)

Inventor

Ludo Edmond Josephine Kennis

Serge Maria Aloisius Peters

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-21

Filing date

1999-12-14

Publication date

2005-01-17

1999-12-14 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2005-01-17 Publication of UA71938C2 publication Critical patent/UA71938C2/uk

Links

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150000002367 halogens Chemical group 0.000 claims abstract description 5
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Psychiatry (AREA)
Emergency Medicine (AREA)
Gynecology & Obstetrics (AREA)
Ophthalmology & Optometry (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)

UA2001064352A 1998-12-21 1999-12-14 BENZYOXAZOLES AND PHENONES AS a2-ANTAGONISTS UA71938C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP98204358		1998-12-21
PCT/EP1999/010054 WO2000037466A1 (en)	1998-12-21	1999-12-14	BENZISOXAZOLES AND PHENONES AS α2-ANTAGONISTS

Publications (1)

Publication Number	Publication Date
UA71938C2 true UA71938C2 (en)	2005-01-17

Family

ID=8234508

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA2001064352A UA71938C2 (en)	1998-12-21	1999-12-14	BENZYOXAZOLES AND PHENONES AS a2-ANTAGONISTS

Country Status (30)

Country	Link
US (1)	US6576640B1 (zh)
EP (1)	EP1140934B1 (zh)
JP (1)	JP4717216B2 (zh)
KR (2)	KR100657540B1 (zh)
CN (1)	CN1154646C (zh)
AR (1)	AR021924A1 (zh)
AT (1)	ATE251622T1 (zh)
AU (1)	AU765751B2 (zh)
BG (1)	BG65162B1 (zh)
BR (1)	BR9916427A (zh)
CA (1)	CA2355716C (zh)
CZ (1)	CZ294532B6 (zh)
DE (1)	DE69911995T2 (zh)
EA (1)	EA003606B1 (zh)
EE (1)	EE200100329A (zh)
ES (1)	ES2209553T3 (zh)
HK (1)	HK1045686B (zh)
HR (1)	HRP20010444A2 (zh)
HU (1)	HUP0104812A3 (zh)
ID (1)	ID28967A (zh)
IL (2)	IL143830A0 (zh)
NO (1)	NO317892B1 (zh)
NZ (1)	NZ511411A (zh)
PL (1)	PL196958B1 (zh)
SK (1)	SK285560B6 (zh)
TR (1)	TR200101813T2 (zh)
TW (1)	TWI229673B (zh)
UA (1)	UA71938C2 (zh)
WO (1)	WO2000037466A1 (zh)
ZA (1)	ZA200105067B (zh)

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MXPA04000036A (es) *	2001-07-05	2004-05-21	Upjohn Co	Benzofuranos sustituidos con (hetero) arilo como ligandos 5-ht.
WO2003082825A1 (en) *	2002-04-03	2003-10-09	Orion Corporation	Use of an alfa2-adrenoreceptor antagonist for cns-related diseases
AU2005233456A1 (en) *	2004-04-12	2005-10-27	Taisho Pharmaceutical Co., Ltd.	Cyclic amine compound
CN101268075A (zh) *	2005-07-28	2008-09-17	百时美施贵宝公司	作为5-羟色胺受体激动剂和拮抗剂的取代的四氢-1h吡啶并[4,3,b]吲哚

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US3419568A (en) *	1966-12-07	1968-12-31	Abbott Lab	Derivatives of 1,2,3,4-tetrahydro-5h-pyrido[4,3b]indoles
US3382250A (en) *	1966-12-07	1968-05-07	Abbott Lab	Aroylalkyl derivatives of 1, 2, 3, 4-tetrahydro-5h-pyrido[4, 3b]indoles
US3718657A (en) *	1970-12-03	1973-02-27	Abbott Lab	Certain-2-substituted-1,2,3,4-tetrahydro-beta or gamma carbolines
JPS4729395U (zh) *	1971-04-26	1972-12-04
AR207799A1 (es) *	1974-04-01	1976-10-29	Pfizer	Procedimiento para preparar azaciclo(3,4-a)-n-fenilindoles-2-substituidos
US4001263A (en) *	1974-04-01	1977-01-04	Pfizer Inc.	5-Aryl-1,2,3,4-tetrahydro-γ-carbolines
US4224329A (en) *	1979-01-23	1980-09-23	Pfizer Inc.	2-Substituted-trans-5-aryl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indoles
FR2570701B1 (fr)	1984-09-27	1987-05-22	Synthelabo	Derives de furo(3,2-c)pyridines, leur preparation et leur application en therapeutique
DE3522959A1 (de) *	1985-06-27	1987-01-08	Merck Patent Gmbh	Indolderivate
EP0339959A3 (en)	1988-04-27	1991-03-20	Glaxo Group Limited	Lactam derivatives
WO1994008040A1 (en) *	1992-09-25	1994-04-14	Synaptic Pharmaceutical Corporation	Dna encoding human alpha 1 adrenergic receptors and uses thereof
US5403847A (en)	1992-11-13	1995-04-04	Synaptic Pharmaceutical Corporation	Use of α1C specific compounds to treat benign prostatic hyperlasia
US5508306A (en) *	1992-11-13	1996-04-16	Synaptic Pharmaceutical Corporation	Aromatic amine derivatives
UA52681C2 (uk) *	1997-04-08	2003-01-15	Янссен Фармацевтика Н.В.	Похідні 1,2,3,4-тетрагідро-бензофуро[3,2,-c]піридину, спосіб їх одержання та фармацевтична композиція на їх основі

1999
- 1999-12-14 BR BR9916427-2A patent/BR9916427A/pt not_active Application Discontinuation
- 1999-12-14 KR KR1020017004946A patent/KR100657540B1/ko not_active IP Right Cessation
- 1999-12-14 EA EA200100709A patent/EA003606B1/ru not_active IP Right Cessation
- 1999-12-14 CZ CZ20012120A patent/CZ294532B6/cs not_active IP Right Cessation
- 1999-12-14 WO PCT/EP1999/010054 patent/WO2000037466A1/en not_active Application Discontinuation
- 1999-12-14 CN CNB998147095A patent/CN1154646C/zh not_active Expired - Fee Related
- 1999-12-14 EE EEP200100329A patent/EE200100329A/xx unknown
- 1999-12-14 NZ NZ511411A patent/NZ511411A/xx unknown
- 1999-12-14 KR KR1020067015507A patent/KR20060093139A/ko not_active Application Discontinuation
- 1999-12-14 JP JP2000589537A patent/JP4717216B2/ja not_active Expired - Fee Related
- 1999-12-14 EP EP99967955A patent/EP1140934B1/en not_active Expired - Lifetime
- 1999-12-14 AU AU24327/00A patent/AU765751B2/en not_active Ceased
- 1999-12-14 CA CA2355716A patent/CA2355716C/en not_active Expired - Fee Related
- 1999-12-14 TR TR2001/01813T patent/TR200101813T2/xx unknown
- 1999-12-14 IL IL14383099A patent/IL143830A0/xx active IP Right Grant
- 1999-12-14 AT AT99967955T patent/ATE251622T1/de not_active IP Right Cessation
- 1999-12-14 SK SK858-2001A patent/SK285560B6/sk unknown
- 1999-12-14 HU HU0104812A patent/HUP0104812A3/hu unknown
- 1999-12-14 ID IDW00200101335A patent/ID28967A/id unknown
- 1999-12-14 UA UA2001064352A patent/UA71938C2/uk unknown
- 1999-12-14 US US09/868,756 patent/US6576640B1/en not_active Expired - Lifetime
- 1999-12-14 DE DE69911995T patent/DE69911995T2/de not_active Expired - Lifetime
- 1999-12-14 PL PL348421A patent/PL196958B1/pl unknown
- 1999-12-14 ES ES99967955T patent/ES2209553T3/es not_active Expired - Lifetime
- 1999-12-16 TW TW088122067A patent/TWI229673B/zh not_active IP Right Cessation
- 1999-12-20 AR ARP990106577A patent/AR021924A1/es active IP Right Grant
2001
- 2001-05-18 BG BG105521A patent/BG65162B1/bg unknown
- 2001-06-06 NO NO20012783A patent/NO317892B1/no unknown
- 2001-06-14 HR HR20010444A patent/HRP20010444A2/hr not_active Application Discontinuation
- 2001-06-19 IL IL143830A patent/IL143830A/en not_active IP Right Cessation
- 2001-06-20 ZA ZA200105067A patent/ZA200105067B/en unknown
2002
- 2002-07-09 HK HK02105098.8A patent/HK1045686B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP4717216B2 (ja)	2011-07-06
TWI229673B (en)	2005-03-21
BG65162B1 (bg)	2007-04-30
CZ294532B6 (cs)	2005-01-12
HUP0104812A2 (hu)	2002-04-29
AU765751B2 (en)	2003-09-25
HK1045686B (zh)	2005-04-01
IL143830A0 (en)	2002-04-21
SK8582001A3 (en)	2001-12-03
HK1045686A1 (en)	2002-12-06
HUP0104812A3 (en)	2003-12-29
WO2000037466A1 (en)	2000-06-29
EA200100709A1 (ru)	2001-12-24
CA2355716A1 (en)	2000-06-29
EP1140934B1 (en)	2003-10-08
ATE251622T1 (de)	2003-10-15
BG105521A (en)	2001-12-29
EA003606B1 (ru)	2003-06-26
ID28967A (id)	2001-07-19
ZA200105067B (en)	2002-06-20
EE200100329A (et)	2002-08-15
BR9916427A (pt)	2001-09-04
ES2209553T3 (es)	2004-06-16
IL143830A (en)	2007-07-24
NO317892B1 (no)	2004-12-27
CA2355716C (en)	2010-05-18
AU2432700A (en)	2000-07-12
CN1331692A (zh)	2002-01-16
EP1140934A1 (en)	2001-10-10
CZ20012120A3 (cs)	2001-10-17
NO20012783L (no)	2001-06-06
NZ511411A (en)	2002-12-20
NO20012783D0 (no)	2001-06-06
DE69911995D1 (de)	2003-11-13
HRP20010444A2 (en)	2002-06-30
PL348421A1 (en)	2002-05-20
TR200101813T2 (tr)	2001-12-21
DE69911995T2 (de)	2004-09-02
SK285560B6 (sk)	2007-03-01
AR021924A1 (es)	2002-09-04
JP2002533341A (ja)	2002-10-08
KR20060093139A (ko)	2006-08-23
KR20010075650A (ko)	2001-08-09
CN1154646C (zh)	2004-06-23
KR100657540B1 (ko)	2006-12-14
US6576640B1 (en)	2003-06-10
PL196958B1 (pl)	2008-02-29

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JPH05331065A (ja)	1993-12-14	セロトニン神経系関連疾患治療剤
CA2023019A1 (en)	1991-02-11	1-oxa-2-oxo-8-azaspiro/4,5/decane derivatives, pharmaceutical compositions containing them and process for preparing the same