UA137242U - GEL FOR THE TREATMENT OF DYSTROPHIC-INFLAMMATORY DISEASES OF PERIODONT AND TRAUMATIC LESIONS OF THE ORAL MUCOUS - Google Patents

Abstract

The tool in the form of a gel for the treatment of dystrophic and inflammatory periodontal diseases and traumatic lesions of the oral mucosa contains metronidazole, propylene glycol and purified water. Additionally contains decamethoxine, dexpanthenol 20%, trimecaine, sodium carboxymethylcellulose, methylcellulose.

Description

The useful model belongs to dentistry and pharmacy and can be used for the treatment of dystrophic-inflammatory diseases of the periodontium and traumatic lesions of the mucous membrane of the oral cavity.

The well-known dental gel for the treatment of inflammatory diseases of the oral cavity, which is the closest analogue (Patent of Ukraine for a utility model Mo 71045, IPC AbITS 17/00 publ. 25.06.2012, Bull. Mo 12), contains in its composition the active substance ceftriaxone (0, 01-0.1) and auxiliary substances: metronidazole (0.5-1.5), propylene glycol (4.0-6.0), carbomer (0.8-1.2), disodium edetate (0.1- 0.6), polyethylene oxide-400 (4.0-6.0), glycerin (4.0-6.0), petroleum jelly (0.05-0.5), tween-80 (0.1-0 .6), triethanolamine (0.05-0.07) and water purified to (100.0).

The disadvantage of the mentioned gel is the presence in its composition of ceftriaxone, which can cause unwanted side reactions in patients with increased sensitivity to it, in particular eosinophilia, leukopenia, thrombocytopenia, diarrhea, rash, allergic dermatitis, itching, swelling, an increase in the level of liver enzymes, sometimes pancreatitis, stomatitis , glossit In addition, the dental gel is not effective enough for the treatment of traumatic lesions of the mucous membrane of the oral cavity.

The basis of a useful model is the task of developing such a tool in the form of a gel, which, thanks to the improvement of the composition and quantitative ratio of the ingredients, will provide anti-inflammatory, antimicrobial, wound-healing, anti-edematous, local pain-relieving effects in the treatment of dystrophic-inflammatory periodontal diseases and traumatic lesions of the mucous membrane of the oral cavity.

The task is solved by the fact that the agent in the form of a gel for the treatment of dystrophic-inflammatory periodontal diseases and traumatic lesions of the mucous membrane of the oral cavity, which contains metronidazole, propylene glycol and purified water, according to a useful model, additionally contains decamethoxine, dexpanthenol 2095, trimecaine, methylcellulose, sodium carboxymethyl cellulose, with the following ratio of ingredients, mass. 9o: metronidazole 0.8-12 decamethoxine 0.08-0.12 dexpanthenol 20 95 8.0-12.0 trimecaine 1.8-22 propylene glycol 8.0-12.0 methylcellulose 4.0-6.0 sodium carboxymethylcellulose 1 ,8-2,2 water purified to 100,0.

Metronidazole in the composition of the gel is an effective antiprotozoal and antibacterial agent with a wide spectrum of action. It shows high activity against Tgispotopav madipaiiv, Siagaia ipiesiiiipaiiv5, Epiatoera pivioiis, Iatrbiia ipieviipiiib5, as well as against obligate anaerobes (spore- and non-spore-forming) - Vasiegioides spp. (V. Ppadii5, V. Omaish5, V. Aiiviavopiv,

Koo) V.Tneiaiotistop, V.myiYidagov), Eivobrasiegisht 5yr., Siovigdisht 5yr., Reriovzigeriososyv v5yr.,

Reriososyv 5yr., Eirasieyepyt. The mechanism of action of metronidazole consists in the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The restored 5-nitro group of metronidazole interacts with the DNA of cells of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria.

Metronidazole is used for the treatment and prevention of infections caused by anaerobic bacteria, in particular in the area of the ear, throat, nose, teeth, mouth, jaw (Regulatory and directive documents of the Ministry of Health of Ukraine. METRONIDAZOL, instructions for use of the drug. (Electronic resource. - Access mode: trans: //togdosv.Kiem.tsalikKimiem.ryr"ia-70061.

Dekamethoxine antiseptic prevents microbial contamination of the gel, showing pronounced bactericidal activity against a wide range of bacteria, fungi, viruses and protozoa. It activates the regeneration of damaged tissues, blocks purulent inflammatory processes, is used for conjunctivitis, gingivitis, periodontitis, tonsillitis, otitis.

Dexpanthenol 20 95 accelerates healing and epithelization of microdamages, wounds, chronic ulcers, cracks in the skin and mucous membranes. It is used to treat periodontitis (catarrhal, ulcerative-necrotic gingivitis, localized periodontitis, generalized periodontitis), inflammatory diseases of the oral mucosa (stomatitis, chronic recurrent aphthous stomatitis), traumatic lesions of the oral mucosa (prosthetic stomatitis). Side effects and allergic reactions when using it almost do not occur or, as an exception, are very rare.

Trimecain provides fast and long-lasting local pain-relieving activity when the gel is applied to the mucous membrane of the oral cavity. It is relatively low-toxic, does not show an irritating or allergic effect.

Optimal amounts of propylene glycol, sodium carboxymethyl cellulose, methyl cellulose and purified water provide the medicinal product with the necessary gel-like consistency, homogeneity and stability during long-term storage.

The tool for the treatment of dystrophic-inflammatory diseases of the periodontium and traumatic lesions of the mucous membrane of the oral cavity is prepared in this way. Calculated amounts of dexpanthenol 2095, metronidazole powder, decamethoxine and trimecaine are dissolved in propylene glycol at a temperature of 40-50 C. Sodium carboxymethyl cellulose and methyl cellulose are infused with purified water for 3-4 hours at room temperature for swelling and complete dissolution. Dexpanthenol 20 95, metronidazole, decamethoxine, trimecaine dissolved in propylene glycol are added to the resulting solution with constant stirring and homogenized for 5-7 minutes until a homogeneous white gel is formed.

Example 1. The gel is prepared as indicated above, with a minimum ratio of ingredients, mass. 9o: metronidazole 0.8 decamethoxine 0.08 dexpanthenol 20 95 8.0 trimecain 1.8 propylene glycol 8.0 methylcellulose 4.0 sodium carboxymethylcellulose 1.68 water purified to 100.0.

Example 2. The gel is prepared as indicated above, with the maximum ratio of ingredients, mass. 9o: metronidazole 1.2 decamethoxine 0.12 dexpanthenol 12.0 trimecaine 2.2 propylene glycol 12.0 methylcellulose 6.0 sodium carboxymethylcellulose 29 vine "water purified to 100.0.

Example 3. The gel is prepared, as indicated above, with the optimal ratio of ingredients, wt. Uo metronidazole 1.0 decamethoxine 0.1 dexpanthenol 10.0 trimecaine 2.0 propylene glycol 10.0 methylcellulose 5.0 sodium carboxymethylcellulose 2.0 water purified to 100.0.

The gel is applied to the affected areas by the application method or under a supragingival self-hardening bandage after professional hygiene accompanied by an antiseptic cover. At home, it is recommended to apply the gel to the gums and mucous membrane of the oral cavity 2-3 times a day for 15-20 minutes.

Clinical example 1. Patient S., 47 years old. Diagnosis: generalized periodontitis of initial - I degree of severity. Treatment: under local anesthesia accompanied by irrigation with a mixture of antiseptics (Z 95 hydrogen peroxide solution and furacilin solution in a 1:1 ratio), all local irritants in the oral cavity were completely eliminated and professional hygiene measures were carried out in full. After that, the gel was applied by the application method to the gums for 15-20 minutes. It was recommended to apply the gel to the gums 2-3 times a day at home.

Clinical example 2. Patient L., 52 years old. Diagnosis: generalized periodontitis of the first degree of severity. Treatment: under local anesthesia and accompanied by antiseptic treatment

From curettage of periodontal pockets, polishing of surfaces and selective grinding of teeth.

The gel was injected into the periodontal pockets and applied to the gums. From above, it was covered with a self-hardening bandage based on "Yupin" alginate mass. The bandage was applied to the edge of the gums, formed with waxed paper on both sides of the alveolar process. Keeping the periodontal bandage for 2-3 hours contributed to the prolongation of the local therapeutic effect. The patient is also recommended: applying the gel to the gums at home.

Clinical example 3. Patient K., 38 years old. Diagnosis: a traumatic (decubitus) ulcer measuring 6 mm on the mucous membrane of the lateral surface of the cheek in the projection of the line of closure of the crowns of teeth 26 and 36.

Treatment: after grinding the overhanging edge of the filling of the 26th tooth and replacing the filling in the 36th tooth and antiseptic treatment with a solution of furacilin in a dilution of 1:5000, the gel was applied to the affected area with exposure for 10 minutes. It was recommended to apply the gel to the affected area 2-3 times a day for 5 days at home.

In all of the above clinical cases, the carrying out of medical procedures provided a positive result, the effectiveness of local therapy and a significant reduction in the period of treatment of patients.

Thus, the positive result of the gel is achieved by the optimal selection of ingredients that provide anti-inflammatory, antimicrobial, wound-healing, anti-edematous, local inflammatory activity without any side effects and prevent the occurrence of dystrophic-inflammatory periodontal diseases and lead to the rapid healing of a traumatic ulcer on the mucous membrane of the oral cavity.

Claims (1)

FORMULA OF THE USEFUL MODEL Means in the form of a gel for the treatment of dystrophic-inflammatory diseases of the periodontium and traumatic lesions of the mucous membrane of the oral cavity, which contains metronidazole, propylene glycol and purified water, which is distinguished by the fact that it additionally contains decamethoxine, dexpanthenol 20 95, trimecaine, sodium carboxymethyl cellulose, methyl cellulose, with the following ratio of ingredients, wt. 9o: metronidazole 0.8-12 decamethoxine 0.08-0.12 dexpanthenol 20 95 8.0-12.0 trimecaine 1.8-22 propylene glycol 8.0-12.0 methylcellulose 4.0-6.0 sodium carboxymethylcellulose 1 ,8-2,2 purified water, the rest.