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UA116455C2 - Сполуки n-піролідинілсечовини, n'-піразолілсечовини, тіосечовини, гуанідину та ціаногуанідину як інгібітори кінази trka - Google Patents

Сполуки n-піролідинілсечовини, n'-піразолілсечовини, тіосечовини, гуанідину та ціаногуанідину як інгібітори кінази trka

Info

Publication number
UA116455C2
UA116455C2 UAA201505770A UAA201505770A UA116455C2 UA 116455 C2 UA116455 C2 UA 116455C2 UA A201505770 A UAA201505770 A UA A201505770A UA A201505770 A UAA201505770 A UA A201505770A UA 116455 C2 UA116455 C2 UA 116455C2
Authority
UA
Ukraine
Prior art keywords
trka kinase
thiourea
pyrrolidinyl
guanidine
pyrazolyl
Prior art date
Application number
UAA201505770A
Other languages
English (en)
Inventor
Шеллі Ален
Барбара Дж. БРАНДХУБЕР
Тімоті Керхер
Габріель Р. Колаковскі
Шанон Л. Вінскі
Original Assignee
Еррей Біофарма Інк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Еррей Біофарма Інк. filed Critical Еррей Біофарма Інк.
Publication of UA116455C2 publication Critical patent/UA116455C2/uk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/14—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

Сполуки Формули І EMBED ISISServer І або її стереомери, таутомери або фармацевтично прийнятні солі, де R1, R2, Ra, Rb, Rc, Rd, X, кільце В та кільце С такі, як визначено в даному документі, і де кільце В та фрагмент NH-C(=X)-NH знаходяться у транс-конфігурації, є інгібіторами кінази ТrkА і застосовуються для лікування таких захворювань, в лікуванні яких можуть застосовуватися інгібітори кінази ТrkА, таких як біль, рак, запалення/запальні захворювання, нейродегенеративні захворювання, деякі інфекційні захворювання, синдром Шегрена, ендометріоз, діабетична периферична нейропатія, простатит або синдром тазового болю.
UAA201505770A 2012-11-13 2013-11-12 Сполуки n-піролідинілсечовини, n'-піразолілсечовини, тіосечовини, гуанідину та ціаногуанідину як інгібітори кінази trka UA116455C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261725913P 2012-11-13 2012-11-13
PCT/US2013/069729 WO2014078323A1 (en) 2012-11-13 2013-11-12 N-pyrrolidinyl, n'-pyrazolyl- urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors

Publications (1)

Publication Number Publication Date
UA116455C2 true UA116455C2 (uk) 2018-03-26

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UAA201505770A UA116455C2 (uk) 2012-11-13 2013-11-12 Сполуки n-піролідинілсечовини, n'-піразолілсечовини, тіосечовини, гуанідину та ціаногуанідину як інгібітори кінази trka

Country Status (33)

Country Link
US (2) US9896435B2 (uk)
EP (2) EP2922844B1 (uk)
JP (3) JP6316834B2 (uk)
KR (1) KR102181915B1 (uk)
CN (2) CN104781255B (uk)
AU (2) AU2013344943B2 (uk)
BR (1) BR112015010875B1 (uk)
CA (1) CA2890876C (uk)
CL (1) CL2015001261A1 (uk)
CY (1) CY1120099T1 (uk)
DK (1) DK2922844T3 (uk)
ES (2) ES2664331T3 (uk)
HK (1) HK1215438A1 (uk)
HR (1) HRP20180331T1 (uk)
HU (1) HUE038512T2 (uk)
IL (1) IL238496B (uk)
LT (1) LT2922844T (uk)
ME (1) ME02990B (uk)
MX (2) MX365733B (uk)
MY (1) MY178262A (uk)
NO (1) NO2876058T3 (uk)
NZ (1) NZ708028A (uk)
PH (1) PH12015500939B1 (uk)
PL (1) PL2922844T3 (uk)
PT (1) PT2922844T (uk)
RS (1) RS57001B1 (uk)
RU (1) RU2677667C2 (uk)
SG (1) SG11201503728XA (uk)
SI (1) SI2922844T1 (uk)
SM (1) SMT201800169T1 (uk)
UA (1) UA116455C2 (uk)
WO (1) WO2014078323A1 (uk)
ZA (1) ZA201503587B (uk)

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