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UA116334C2 - Тверді форми дозування бендамустину - Google Patents

Тверді форми дозування бендамустину

Info

Publication number
UA116334C2
UA116334C2 UAA201404416A UAA201404416A UA116334C2 UA 116334 C2 UA116334 C2 UA 116334C2 UA A201404416 A UAA201404416 A UA A201404416A UA A201404416 A UAA201404416 A UA A201404416A UA 116334 C2 UA116334 C2 UA 116334C2
Authority
UA
Ukraine
Prior art keywords
solid forms
pharmaceutically acceptable
bendamustine
dosage
bendamustine dosage
Prior art date
Application number
UAA201404416A
Other languages
English (en)
Inventor
Джеффрі Колледже
Томас Альфред Профітліх
Ульріх Патзак
Таоуфік Оуатас
Марґарета Ольтофф
Original Assignee
Астеллас Дойчленд Ґмбг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Астеллас Дойчленд Ґмбг filed Critical Астеллас Дойчленд Ґмбг
Publication of UA116334C2 publication Critical patent/UA116334C2/uk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Винахід стосується фармацевтичної композиції у твердій формі дозування, для перорального призначення, що містить як активний інгредієнт бендамустин або його фармацевтично прийнятний естер, сіль або сольват, і комбінацію двох фармацевтично прийнятних сахаридних наповнювачів, якими є мікрокристалічна целюлоза та манітол, де співвідношення мас активного інгредієнта відносно сахаридних наповнювачів є у межах 1:0,8-10,5, та в якому композиція є у формі таблеток, гранулятів або пігулок.
UAA201404416A 2008-12-03 2009-12-03 Тверді форми дозування бендамустину UA116334C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08020996 2008-12-03
UAA201106236A UA107186C2 (xx) 2008-12-03 2009-03-12 Тверді форми дозування бендамустину

Publications (1)

Publication Number Publication Date
UA116334C2 true UA116334C2 (uk) 2018-03-12

Family

ID=40588072

Family Applications (2)

Application Number Title Priority Date Filing Date
UAA201106236A UA107186C2 (xx) 2008-12-03 2009-03-12 Тверді форми дозування бендамустину
UAA201404416A UA116334C2 (uk) 2008-12-03 2009-12-03 Тверді форми дозування бендамустину

Family Applications Before (1)

Application Number Title Priority Date Filing Date
UAA201106236A UA107186C2 (xx) 2008-12-03 2009-03-12 Тверді форми дозування бендамустину

Country Status (26)

Country Link
US (4) US20120003309A1 (uk)
EP (1) EP2367538B1 (uk)
JP (3) JP5658679B2 (uk)
KR (1) KR101710935B1 (uk)
CN (2) CN107080742B (uk)
AU (1) AU2009321728B2 (uk)
BR (1) BRPI0922804B8 (uk)
CA (1) CA2745509A1 (uk)
CO (1) CO6400185A2 (uk)
CY (1) CY1119839T1 (uk)
DK (1) DK2367538T3 (uk)
EA (1) EA028179B1 (uk)
ES (1) ES2645008T3 (uk)
HR (1) HRP20171421T1 (uk)
HU (1) HUE036481T2 (uk)
IL (1) IL213269A (uk)
LT (1) LT2367538T (uk)
MX (1) MX2011005633A (uk)
NZ (1) NZ592971A (uk)
PL (1) PL2367538T3 (uk)
PT (1) PT2367538T (uk)
RS (1) RS56408B1 (uk)
SI (1) SI2367538T1 (uk)
UA (2) UA107186C2 (uk)
WO (1) WO2010063476A2 (uk)
ZA (1) ZA201103790B (uk)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA107186C2 (xx) * 2008-12-03 2014-12-10 Тверді форми дозування бендамустину
EP2575784B1 (en) 2010-06-02 2018-08-08 Astellas Deutschland GmbH Oral dosage forms of bendamustine
JO3659B1 (ar) * 2010-06-02 2020-08-27 Astellas Deutschland Gmbh أشكال جرعات بينداموستين عن طريق الفم وإستخداماته العلاجية
CN102375044B (zh) * 2010-08-18 2015-04-08 重庆华邦胜凯制药有限公司 一种盐酸苯达莫司汀中间体z6有关物质的分析方法
EP2641592A1 (en) 2012-03-23 2013-09-25 Salmon Pharma GmbH Pharmaceutical formulation comprising bendamustine
JP2016153374A (ja) * 2013-06-25 2016-08-25 シンバイオ製薬株式会社 炎症性疾患を治療又は予防するための医薬組成物
EP3043648B1 (en) * 2013-08-27 2023-09-20 Vasilios VOUDOURIS Bendamustine pharmaceutical compositions
CN105566226B (zh) * 2014-05-06 2019-06-21 南京先声东元制药有限公司 盐酸苯达莫司汀二聚体的制备方法与应用
JP6608193B2 (ja) * 2014-06-27 2019-11-20 花王株式会社 固形状組成物
WO2016005995A2 (en) * 2014-07-10 2016-01-14 Leiutis Pharmaceuticals Pvt. Ltd. Glycol free stable liquid compositions of bendamustine
JP5897196B1 (ja) * 2015-10-05 2016-03-30 大同化成工業株式会社 糖又は糖アルコール、膨潤型結合剤、崩壊剤及び高吸収性賦形剤を含む複合化造粒物及びその製造方法
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