TWM469045U - A dual wavelength cartilage repairing phototherapy device using nanogold mixed biological gel - Google Patents

Abstract

This invention provides a dual wavelength phototherapy device for cartilage repairing using nanogold mixed biological gel. The phototherapy device consists of one or two light sources, a power supply and a control panel. The output light of the said light source is delivered to the treated cornea via an optical set, optical fiber or a hand piece or an endoscope. The said device may also consist of an observing endoscope having an infrared fiber probe. The said light source can be a laser or a LED having a wavelength range of 750 to 980 nm or UV-blue at 350 to 460 nm. The said device provides quantitative, time controlled and adjustable speed for photo polymerization or gelling via the irradiation light power, period and modes. The power of the UV-blue or the infrared light at the treated area is 0.1 to 10 W depending on its spot size of 1.0 to 20 mm. The treating period range is 10 to 600 seconds.

Description

Dual-wavelength cartilage repair phototherapy instrument using nano gold bio glue

This creation is about a laser orthopedic treatment device, especially a dual-wavelength cartilage repair phototherapy instrument using nano gold bio glue.

Articular cartilage extracellular matrix defects caused by degenerative arthritis are clinically very common. Because chondrocytes are terminally differentiated cells with extremely weak proliferative capacity, lack of regenerative capacity, and repair after cartilage trauma is very difficult. Cartilage defects or injuries have always been a major problem in surgical clinical treatment. The use of smart polymer water gel and tissue engineering technology to promote tissue regeneration has become a method for the treatment of articular cartilage lesions. Smart water gel can respond to the environment, such as light or temperature changes such as reversible volume phase transition or sol-gel phase transition, has been widely used in fixed-point control drug release and tissue engineering research.

At present, the technology uses temperature-sensitive water gel, which relies on human body temperature to produce a gel, or uses a light-sensitive water gel to form a water gel by ultraviolet (UV) photopolymerization. Prior art lacks quantitative temperature control and adjustable speed photopolymerization. Furthermore, the current technology uses a single-wavelength light source to continuously emit light, and its ultraviolet light energy penetration depth is limited.

In view of the above prior art background, the purpose of this creation is to propose a new cartilage repair phototherapy instrument that combines nanogold and bioglue and uses dual wavelength technology. The technology provides advantages such as quantitative timed temperature control and adjustable speed violet blue or infrared gelation, which are not available in the prior art.

This creation provides a dual-wavelength cartilage repair phototherapy device using nanogold bioglue. The cartilage phototherapy apparatus comprises: one or two light sources, a power supply, and a panel control display. The light source output light is output via an optical lens set or fiber optic or handle. Energy can also be delivered to the cartilage repair treatment site via a transmission endoscope. The light source includes a near-infrared laser or LED light source (wavelength 750 to 980 nm), and may also include a violet-blue light source (wavelength 350 to 460 nm). See the following examples for details.

(10) (100)‧‧‧ Power supply

(11,12)‧‧‧ Panel Control Display

(13)‧‧‧Manual switch

(14)‧‧‧ Foot switch

(15)‧‧‧Power cord

(20)‧‧‧Light source

(30)‧‧‧Optical lens group

(21) (104)‧‧‧ Output light

(30)‧‧‧Optical lens group

(21)‧‧‧ Output light

(22)‧‧‧Glenoptic lens

(22) ‧‧‧ positive lens

(32)‧‧‧negative lens

(103)‧‧‧Optical fiber

(30) ‧‧‧handle

(201)‧‧‧Transmission fiber

(202)‧‧‧Transmission of endoscopes

(200) ‧ ‧ human body

(203) ‧‧‧Cartilage repair treatment site

(204)‧‧‧Injection syringe

(205)‧‧‧Fiber Optic Probe

(206) ‧‧‧Viewing endoscopes

Figure 1 is a schematic diagram of the planar structure of the system of the present creation.

Figure 2 is a schematic view of the optical lens set of the present invention.

Figure 3 is a schematic diagram of another system planar structure of the present invention.

Figure 4 is a schematic diagram of another system structure of the present creation.

Example 1:

As shown in Fig. 1, the present invention provides a cartilage phototherapy apparatus comprising: a power supply (10) and a panel control display (11, 12), the power supply (10) being connected via a power line (15) To the light source (20), The light source (20) outputs light (21) to control the size of the output spot at the treated site via the optical lens set (30). The control of the phototherapy apparatus illumination time includes: a manual switch (13), a panel control (11) or a foot switch (14). The panel control parameters include: output light illumination time display (11), output light power display (12), and illumination mode (not shown in Figure 1). The irradiation mode may be continuous or pulsed, the pulse width is 0.001 second to 2 seconds, and the irradiation time ranges from 10 seconds to 600 seconds. The light source (20) comprises a violet blue laser or LED light source, the output light (104) comprising a wavelength range of 350 to 460 nm.

As shown in FIG. 2, the optical lens group (30) changes the spot size of the output light (21) at the treated site via a poly lens (22) position moving distance (L), and the spot size can also be different from the treated site. (R1, R2). As shown in FIG. 2, the optical lens group may also include a set of positive lens (22) and negative lens (32), and the spot size is adjusted by a negative lens (32) position moving distance (L). The above-mentioned polylens (22), positive lens (22) and negative lens (32) have a focal length ranging from 0.5 to 10 cm, and the spot has a diameter ranging from 1.0 to 20 mm at the site to be treated.

Example 2:

As shown in FIG. 3, the cartilage phototherapy apparatus comprises: a light source (100) and a panel control display (11, 12). The light source (100) connects its output light (104) to an optical fiber (103) and a handle (30) having an optical lens set (not shown in FIG. 3) via a fiber coupler (not shown in FIG. 3). . The panel control parameters include an output light illumination time display (101), an output light power display (102), and an illumination mode (not shown in FIG. 3). The irradiation mode may be continuous or pulsed, the pulse width is 0.001 second to 2 seconds, and the irradiation time ranges from 10 seconds to 600 seconds. The light source (100) includes a near infrared laser or LED light source, the output light (104) comprising a wavelength range of 750 to 980 nm. The light source (100) may also include a violet blue laser or LED light source, the output light (104) comprising a wavelength range of 350 to 460 nm.

Example 3:

As shown in FIG. 4, the cartilage phototherapy apparatus includes one or two light sources (10) and (100), and the output light transmits energy to the human body via the transmission fiber (201) and a transmission endoscope (202). Cartilage repair treatment site (203). The cartilage phototherapy apparatus can also include a bio-sensitive or temperature-sensitive bio-gel injection syringe (204). The syringe (204) biogel is delivered to the cartilage repair treatment site (203) via the endoscope (202). The bio-adhesive includes photo-sensitive polyethylene glycol diacrylate (PEGDA), or a blend of nano-rod or nano-shell warm-type polyaspartic acid (PNA) water gel or Hydrophilic bioglue with similar functions. The cartilage phototherapy apparatus can also include another viewing endoscope (206) with an infrared fiber optic probe (205) for positioning or observing cartilage repair. The transmission endoscope (202) of the cartilage phototherapy apparatus can also pass through a transmission fiber (201), a bio-injection syringe (205) and an infrared fiber probe (205).

The photo-sensitive polyethylene glycol diacrylate (PEGDA) is polymerized by violet blue light of a phototherapy apparatus. On the other hand, the blended nanogold warm-sensing polyaspartic acid (PNA) is gelled by infrared light (IR) of a phototherapy apparatus. Photopolymerization or gelation at a quantitative timing and an adjustable speed can be achieved by controlling the power of the illumination light, the irradiation time, and the manner of irradiation. The power of the purple-blue or infrared output light in the cartilage repair treatment site ranges from 0.1 watt to 10 watts, depending on the diameter of the treatment site (1.0 to 20 mm). The treatment site irradiation time ranges from 10 seconds to 600 seconds.

(10)‧‧‧Power supply

(11,12)‧‧‧ Panel Control Display

(13)‧‧‧Manual switch

(14)‧‧‧ Foot switch

(15)‧‧‧Power cord

(20)‧‧‧Light source

(30)‧‧‧Optical lens group

(21)‧‧‧ Output light

Claims (7)

A cartilage repair phototherapy device. The cartilage repair phototherapy apparatus includes: a light source connected to a power supply via a power line; the power supply unit includes a panel control display; and an optical lens set connected to the light source, the light source output light is controlled The spot size of the cartilage treatment site. The cartilage repair phototherapy apparatus according to claim 1, wherein the light source is a laser or an LED light source, and the output light wavelength is 350 to 460 nm or 750 to 980 nm; the output light may be continuous light or pulse. The output is from 1 to 1,000 Hz and the output power is from 0.1 watt to 10 milliwatts at the cartilage treatment site. The cartilage repair phototherapy apparatus according to claim 1, wherein the panel control display display parameter comprises: an output light illumination time display, an output light power display, and an illumination mode; the illumination mode may be continuous or pulse; the pulse width is 0.001 In seconds to 2 seconds, the exposure time is 10 seconds to 600 seconds. The cartilage repair phototherapy apparatus according to claim 1, wherein the optical lens set comprises a movable lens of a movable lens having a focal length ranging from 0.5 to 10 cm for changing a spot diameter of the output light at the cartilage treatment site. The range is 1.0 to 20 mm. The cartilage repair phototherapy apparatus according to claim 1, wherein the output light is connected via an optical fiber to a handle in which the optical lens group is built. A cartilage repair phototherapy apparatus includes: one or two light sources; the output light transmits energy to the cartilage treatment site via a transmission fiber and a transmission endoscope; and may also include: An injection syringe containing a bioglue; the bioglue is transmitted to the cartilage treatment site via the transmission endoscope; and may also include: an observation endoscope having an infrared fiber optic probe therein. The cartilage repair phototherapy apparatus according to claim 6, wherein the bio-adhesive comprises: photo-sensitive polyethylene glycol diacrylate (PEGDA), or a blend of nano-gold rods or nano-gold shells. Indoleamine (PNA) water gel, or a similar functional hydrophilic bioglue.