TWI245605B - Method for producing nutritional product containing L-Arginine - Google Patents

Abstract

A method for producing a nutritional product containing L-Arginine comprises: (a) arbitrarily mixing L-Arginine with at least one ingredient selected from the group consisting of acid-flavoring agents, sweeteners, coloring material, fillers, flavors, and lubricants, and all or a portion of the nutritional supplements other than L-Arginine in the production of the invented product in the presence of ethanol, and performing a wet granulation process; (b) drying the obtained wet granules; (c) selectively processing the dried granules obtained from step (b); and (d) adding the rest of the ingredients when the ingredients added in step (a) are only a portion of the whole ingredients.

Description

1245605 (1) 发明 Description of the invention [Technical field to which the invention belongs] The present invention relates to a method for manufacturing a nutritional supplement product containing L-spermine acid, in particular to use ethanol to make spermine-containing 酉 by wet granulation method Change to nutritional supplements. [Background of the Invention] L-Arginine is an amine acid required by the human condition. Scientists first isolated pure L-arginine from animal rhino horns at the end of the 19th century. L-arginine is the sole source of creatinine in the body, and sarcosine is a substance necessary for ATP regeneration. L-arginine can also increase the release of blood glucose hormones and insulin, and mediate abnormal blood glucose. In addition, L-arginine has been successfully used to improve male sperm production and treat metabolic alkalosis. Three scientists, including Ferid Murad, Robert F. Furchgott, and Louis J. Ignarro, discovered that nitric oxide (NO) is an important substance that transmits signals everywhere in the human body. In 998, he won the Nobel Prize in Biomedicine. NO is a physiological gas that is produced by cells and penetrates cell membranes to regulate cell functions. L-Arginine is a nitrogen-rich amino acid that has twice the nitrogen content of other amino acids. It is a very important physiological precursor of N 0. L-Arginine is catalyzed by NO synthetase. Generates NO, which represents a relaxing factor on the inner wall of blood vessels, which regulates the diastolic elasticity of the entire cardiovascular system to ensure adequate supply of oxygen throughout the body, while adjusting the function of the vascular endothelium, and preventing lipids and blood. The adhesion of white blood cells, etc., keeps the blood flow in the blood vessel lumen unobstructed. L-Arginine can be found in foods with high protein content. Generally, healthy people can make enough L-Arginine daily. However, in some cases, it must be supplied in additional ways to maintain the normal body. Features. [Previous technology] The present invention relates to a method for manufacturing a nutritional supplement product containing L-arginine. The main component of the nutritional supplement product is L-arginine. Other condiments can be acidulants, sweeteners, spices, Pigments and / or lubricants. Existing L-arginine-based powdered nutritional supplement products are manufactured by mixing powder directly or wet granulating with water or aqueous solution. However, both of these manufacturing methods have their own advantages. Weaknesses or difficulties. The method of direct powder mixing is to directly mix the ingredients, but to use this method, each ingredient powder must meet a number of height requirements, including: Each ingredient powder must be uniform in size, then the uniformity of the ingredients will be good after mixing; The density of the powder is high, so that the product will not be fluffy after being mixed, and will not fly when filled; if the powder has good fluidity, the bagging speed will be fast. However, it is difficult for each component powder to fully meet these requirements. Therefore, it has been manufactured by wet granulation, that is, by adding liquid and wet granules. In addition, when the powder is directly mixed, there is also a problem in filling and packaging. The reason is that the nutritional supplement product is hygroscopic. Taking aluminum foil packaging as an example, when the powder mixture of various ingredients is filled with powder, There is a flying phenomenon. After flying, some powder will stick to the edge of the aluminum foil bag, making the sealing bag unable to be tightly sealed, and the phenomenon of moisture absorption and agglomeration during storage. To -5- (3) 1245605 When using water or aqueous solution for wet granulation to manufacture this product, the product has strong hygroscopicity and high viscosity after absorbing moisture. Wet manufacturing with water or aqueous solution Due to the high viscosity in the granulation process, it is difficult to carry out the process smoothly. [Summary of the Invention] In order to solve the above-mentioned problems, the inventors found after research that when granulating with ethanol or an ethanol solution to produce the nutritional supplement product, the granulation process is extremely smooth, eliminating the need to directly mix the powder The manufacturing method is related to the various characteristic requirements and disadvantages of each component powder, and it also improves the problem of high viscosity that affects operation when wet granulation is performed with water or aqueous solution. Therefore, the present invention provides a method for manufacturing a nutritional supplement product containing L-arginine, comprising: (a) L-arginine, at least one selected from the group consisting of an acidulant, a sweetener, a pigment, and a tincture , Spices and lubricants, and supplementary substances other than L-arginine, which are used selectively, all or part of all ingredients used in the manufacture of this product are mixed with ethanol in any order and wet-processed Granules; (b) drying the obtained wet granules; (c) selectively granulating the dried granules of step (b); and (d) when the ingredients involved in the mixing in step (a) are used to manufacture the product For all ingredients, add the remaining ingredients and mix. In addition to avoiding the problem of direct mixing of dry powder and improving the disadvantages of water-wet granulation, which is difficult to operate, the method of the present invention also gives a number of excellent -6- (4) 1245605 points, such as: no water-wet method The dough-like phenomenon of the granulation method occurs, the drying time is short, the drying temperature is low, the product is not easy to agglomerate, the particles are uniform, the total surface area is small (that is, the particles are larger), the pigment is evenly distributed on the particles, so the acceptance of the product, Good fluidity, easy filling and packaging, fast dissolving speed when the product is in water, etc. In addition, the use of ethanol has an additional bactericidal effect during the manufacturing process. [Embodiment] The nutritional supplement product of the present invention is mainly composed of L-arginine, and its amount is not particularly limited, and may be about 30 to about 80% by weight based on the total amount of the product ingredients. The nutritional supplement product of the present invention is a mixture of granules, which can be used after being added to water before use. Since L-arginine is an amino acid with a fishy smell, it will leave an unpleasant feeling when the L-arginine solution is used alone. Therefore, products without added flavoring agents are not easily accepted by consumers. It can be used for flavoring substances such as sour, sweetener, and flavor. The sour agent used in the present invention may be one commonly used in the food or pharmaceutical industry, such as citric acid, malic acid, etc., and the amount thereof is not particularly limited so as to be able to produce a sour taste suitable for mouthfeel, but a sufficient amount of the sour agent can be removed The unpleasant fishy smell of the aforementioned amino acid. The use of sweeteners can further increase consumer acceptance. The sweeteners used in the present invention can be those commonly used in the food or pharmaceutical industry, such as aspartame, Acesulfame K glycyrrhizine, stevia ( Stevia), sucrose, etc. It can be used in an amount of (5) 1245605 to produce a sweetness suitable for mouthfeel. The flavors used in the present invention may be those commonly used in the food or pharmaceutical industry, such as fruity flavors. The pigments used in the present invention may be those commonly used in the food or pharmaceutical industry. The choice of color can be used in combination with spices. For example, when orange flavor is used, orange pigment can be used in combination. The ingredients used in the products of the present invention may also include lubricants, which may be those commonly used in the food or pharmaceutical industries, such as silicon dioxide, magnesium stearate, titanium dioxide, and the like. The ingredients used in the products of the present invention may also contain tinctures, which may be those commonly used in the food or pharmaceutical industries, such as Xylitol, lactose, mannitol, polyethylene Alcohol (polyethylene glycol), etc. Some consumers may not like the sourness of sour agents. In this case, they can reduce the amount of sour agents and replace them with tinctures. The ingredients used in the products of the present invention may also include other nutritional supplement products other than L-arginine, such as sugarcane (ρ ο 1 ic 〇sa η ο 1), lycopene, red tincture, cyanobacteria, Wheat seed powder and so on. There are no particular restrictions on the amount of each condiment used in this case, such as sour agents, sweeteners, pigments, flavors, lubricants, and fillers, and the amounts are those that can be judged by those in the food or pharmaceutical fields and can be adjusted as needed. The method for producing a nutritional supplement product containing L-arginine according to the present invention includes the following steps: (a) selecting L-arginine, at least one selected from the group consisting of an acidulant, a sweetener, a colorant, a tincture, a flavor, and Additives for lubricants, and optionally make use of -8-(6) 1245605 nutritional supplements other than L-arginine, etc. All or part of all ingredients used to make this product are mixed with ethanol in any order And wet granulation; (b) drying the obtained wet granules; (c) selectively granulating the dried granules of step (b); and (d) when the ingredients involved in mixing in step (a) are used When manufacturing all the ingredients of the product, there is no particular limitation on the order of adding the ingredients in the method of the present invention after the rest of the ingredients are added, but it is better to add the lubricant and fragrance after drying and granulating. The reason is that the lubricant is a particulate medium, which buffers between particles, reduces friction between particles, and increases the fluidity of particles to facilitate filling. As for the fragrance, it is generally volatile. In order to prevent it from being volatilized during the drying or granulation process, it should be added after the drying and granulation steps. In addition, in order to allow the ethanol to be evenly distributed on the component particles, the timing of the addition of ethanol should be after mixing L-spermine, sour, sweetener, pigment, tincture; or, after L-sperine, sour After the agent, sweetener and tincture are mixed, an ethanol solution formed by dissolving the pigment in ethanol is added to the mixture. The ingredients can be honed and sieved before they are mixed. In step (a), the amount of ethanol used is about 3 to about 30 parts by weight, and preferably about 6 to about 15 parts by weight based on the total amount of ingredients used. The ethanol used can be added all at once or in several times; ethanol can be added separately or after dissolving the pigment. Mixing and making in step (a) (8) 1245605

Ingredients such as Sunset Yellow are added to the Supermixer in the amounts listed in Table 1 and mixed first, and then L-arginine is added to the Supper r m i X e r and mixed. After ethanol (90 g) was added to the obtained mixture, wet granulation was performed. The wet granules produced by the wet granulation were dried in an oven at 60 ° C for 2 hours, and then granulated with a Fitzmi 11 through a No. 20 sieve. Then, C ab-0-S i 1 and orange flavor were added. The spices are mixed with V-blender and packaged. Table 1 Ingredient Function Weight Percent 1 kg Batch L-Arginine Main Ingredients 6 4.94% 0.6494 kg Malate Sour Flavor 2 6.00% 0.2600 kg Citric Sour Flavor 6.50% 0.0650 kg Aspartame Sweet Sweetener 0.60% 0.0060 kg Acesulfame K Sweetener 0.40% 0.0 0 4 0 kg Sunset Yellow Pigment 0.06% 0.0006 kg Orange Flavor Spice 0.60% 0.0060 kg Cab-O-Sil Lubricant 0.90% 0.0090 kg Comparative Example 1 Malic acid, citric acid, aspar Ingredients such as sweet and Acesulfame K are added to the Supermixer in the amounts listed in Table 1 and mixed first, and then L-Arginine is added to the Supermixer and mixed. After the pigment Sunset Yellow was dissolved in water (30 g), the pigment aqueous solution was added to the mixture, followed by wet granulation. The generated wet granules are dried in an oven at 60 ° C for 3 hours, and granulated through a No. 20 sieve in a Fitzmill, then added -11-1245605 Ο)

Cab-0-Sil and orange flavor 'are mixed with V-blender and packaged. The following compares the manufacturing process and products of Example 1 and Comparative Example 1, as shown in Table A below.

-12- (10) 1245605 Agglomeration When the amount of residual water is high, the product tends to agglomerate under storage conditions. The affinity of the ingredients for ethanol is not high, and in the case of residual ethanol, the product is not easy to agglomerate. Sterilization There is no additional bactericidal effect during the granulation process. Due to the ethanol treatment, there is an additional bactericidal effect during the granulation process.

Example 2

Add malic acid, citric acid, xylitol, aspartame, Acesulfame K, and pigment Erythrosine Aluminum Lake to the Supermixer in the amounts listed in Table 2 below, mix them first, and then add L-Arginine to the S upermi X er mixed. After adding ethanol (90 g) to the obtained mixture, wet granulation was performed. The wet granules produced by wet granulation are dried in an oven at 60 ° C for 2 hours, and then granulated through a No. 20 sieve in a Fitzmill. Then add Cab-0-Sil and strawberry flavor spices, and then use V-blender Mix and package. -13- (11) 1245605 Table 2 Ingredient Function Weight Percent 1kg Bulk L-Arginine Main Ingredients 6 4.94% 0.6494 kg Malic Acid Sour Agent 13.00% 0. 1 3 0 0 kg Citric Acid Sour Agent 3.25% 0.0325 kg Wood Sugar alcohol tincture 16.07% 0.167 kg Aspartame sweetener 0.60% 0.0060 kg Acesulfame K sweetener 0.40% 0.0040 kg Erythro sine Pigment 0.04% 0.0004 kg Aluminum Lake Strawberry Flavor Spice 0.80% 0.0080 kg Cab -O-Sil lubricant 0.90% 0.0090 kg

Example 3

Add malic acid, citric acid, xylitol, aspartame, Acesulfame K, and the pigment Tartarine Aluminum Lake to the Supermi X er in the amounts listed in Table 3 below, mix them first, and then add L-arginine Add this Super mixer and mix. After adding ethanol (90 g) to the obtained mixture, wet granulation was performed. The wet granules produced by the wet granulation are dried in an oven at 60 ° C for 2 hours, and the whole granules are passed through a No. 20 sieve in a Fitzmill. Then add Cab-0-Sil and mango flavor, and then use V-blender Mix and package. -14- (12) 1245605 Table 3 Ingredient function ------- weight percentage 1 kg batch L-arginine main ingredient 6 4.94% 0 · 6 4 9 4 kg malic acid flavoring agent 13.00% 0. 1 3 00 kg citric acid sour agent 3.25% ___ 0.0325 kg xylitol tincture 16.06% 0. 1 6 0 6 kg aspartame sweetener 0.60% 0.0060 kg Acesulfame K sweetener 0.40% 0.0 0 4 0 kg T artrazine Pigment 0.05% 0.0005 kg Aluminum Lake Mango Flavor Spice 0.80% 0.0080 kg Cab-O-Sil Lubricant 0.90% 0.0090 kg Example 4 After citric acid honing and passing through a No. 60 sieve (particle size 250 μm), Add L-arginine, malic acid, milled citric acid, aspartame, and Acesulfame to the squeeze as shown in Table 4 below and mix. Dissolve Sunset Yellow in ethanol, and then slowly add the aforementioned ethanol solution of Sunset Yellow to the mixture in the container during the stirring process. During the stirring process, add two to three times of ethanol to the obtained mixture (total ethanol) The total amount is 90 g), and wet granulation is performed. The obtained mixed wet granules were placed in a drying box, and the ethanol was removed at a drying temperature of 60 ° C, and then the dry granules after removing the ethanol were sieved. The sieved dry granules are poured into V-blender, and orange flavor is added separately with Cab-0-Sil for -15- (13) 1245605 and packaged. Table 4

Ingredient Function Weight Percent 1kg Bulk L-Arginine Main Ingredients 6 4.94% 0.6 4 9 4 kg Malic Acid Sour Agent 2 6.00% 0.2600 kg Citric Acid Sour Agent 6.50% 0.0650 kg Aspartame Sweet Sweetener 0.60% 0.0060 kg Acesulfame K 0.40% 0.0040 kg Sunset Yellow Pigment 0.06% 0.0006 kg Orange Flavor Spice 0.60% 0.0060 kg Cab-O-Sil Lubricant 0.90% 0.0090 kg

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Claims (1)

1245605 Patent application scope No. 92 1 1 5 7 1 5 Chinese patent application scope Amendment June 3, 1994 Amendment 1 · A method for manufacturing nutritional supplement products containing L-arginine , Including: (a) at least one L-arginine, selected from the group consisting of sour agents, sweeteners, pigments, tinctures, flavors, and lubricants; and optionally L-arginine Nutritional supplements All or part of all the ingredients used to make this product are mixed with ethanol in any order and wet granulated; (b) the obtained wet granules are added at a temperature of about 50 to about 75 ° C Drying; (0) optionally adding the dried granules of step (b) to whole granules; and (d) when the ingredients involved in the mixing in step (a) are part of all ingredients used to make the product, the remaining ingredients After the addition, mixing is performed; wherein the amount of L-arginine is about 30 to about 80% by weight based on the total ingredients of the nutritional supplement product; the amount of ethanol used is based on 100% of the total ingredients of the nutritional supplement product From about 3 to about 30 parts by weight; The steps (c) and (d) following the drying step (b) of the granules are performed at a relative humidity of about 40% to about 60%. 2. The method according to item 1 of the scope of patent application, including ... a 1) mixing L-arginine, sour agent, sweetener, pigment and tincture for selective 1245605; (a2) adding ethanol to the mixture obtained in step (a 1), and then performing a wet method Granulation; (b) drying the obtained wet granules; (c) granulating the dried granules of step (b); and (d) adding perfume and / or lubricant to the granulated granules and mixing. 3. The method according to item 1 of the patent application scope, comprising: (al) mixing L-arginine, sour agent, sweetener, and optionally used fillers; (a2) dissolving the pigment in ethanol (A3) adding the above-mentioned pigmented ethanol solution to the mixture obtained in step (al) to perform wet granulation; (b) drying the obtained wet granules; (c) integrating the dried granules in step (b) Granules; and (d) adding flavors and / or lubricants to the aforementioned granulated granules and mixing. 4. If a patent is applied for The method according to any one of items 1 to 3, which comprises the step of honing and / or sieving all or part of the ingredients used before step (a) or step (a 1). 5 · If applied The method of any one of the scope of patents 1 to 3, further comprising the step (e) of packaging. 6 · The method of the fifth scope of the patent application, wherein the step (e) of the packaging is about 40% to about The relative humidity is 60%. 1245605 7. The method according to any one of claims 1 to 3, wherein the amount of ethanol used is about 1,000 parts by weight based on the total amount of ingredients of the nutritional supplement product. 6 to about 15 parts by weight. -3