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TW202448485A - 肌萎縮蛋白外顯子跳躍寡核苷酸 - Google Patents

肌萎縮蛋白外顯子跳躍寡核苷酸

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TW202448485A
TW202448485A TW113116532A TW113116532A TW202448485A TW 202448485 A TW202448485 A TW 202448485A TW 113116532 A TW113116532 A TW 113116532A TW 113116532 A TW113116532 A TW 113116532A TW 202448485 A TW202448485 A TW 202448485A
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lna
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湯瑪士 艾倫 哈特
喬許 克里斯多佛 沃羅斯內克
史蒂芬 麥可 弗羅利希
查爾斯 法蘭斯 五世 寇勒
珍娜 瑪麗 馬加特
伊莎 達米
班傑明 史潘格勒
德博布拉托 達斯
布萊特 尤金 克羅福德
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美商拜奧馬林製藥公司
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Abstract

本文提供誘導人類肌萎縮蛋白前驅mRNA之外顯子53跳躍的反義寡核苷酸(ASO)及其醫藥學上可接受之衍生物。亦提供含有該等ASO之醫藥組成物以及使用該等ASO及該等組成物來治療患有杜顯氏肌肉萎縮症之個體的方法。

Description

肌萎縮蛋白外顯子跳躍寡核苷酸
本文提供用於肌萎縮蛋白外顯子跳躍及治療杜顯氏肌肉萎縮症之組成物及方法的反義寡核苷酸。
反義寡核苷酸(ASO)正處於包括癌症、發炎病狀、心血管疾病以及神經退化性及神經肌肉病症在內之許多疾病及病狀的臨床(前)開發階段。它們的作用機制針對各種目標，諸如細胞核或細胞質中RNaseH介導之靶標RNA降解、細胞核中之剪接調節(外顯子內含或跳躍)或藉由細胞質中核糖體亞基結合之空間位阻來達成的轉譯抑制。剪接調節或剪接轉換ASO最初係描述用於校正人類β-珠蛋白前驅mRNA中之異常剪接(Dominski及Kole PNAS, 1993, 90(18):8673-8677)，且目前正在研究用於多種遺傳病症。
ASO在神經肌肉病症杜顯氏肌肉萎縮症(Duchenne muscular dystrophy，DMD)及貝克爾肌肉萎縮症(Becker muscular dystrophy，BMD)之治療中得到廣泛研究。杜顯氏肌肉萎縮症(DMD)及貝克爾肌肉萎縮症(BMD)為最常見的兒童期形式之肌肉萎縮症。DMD為一種嚴重的、致命性神經肌肉病症，使得在12歲之前依賴輪椅支持，並且患者常常在30歲前死於呼吸或心臟衰竭。其係由一或多個外顯子之閱讀框移位缺失(約67%)或重複(約7%)，或由2.24 Mb肌萎縮蛋白基因中之點突變(約25%)引起，導致功能性肌萎縮蛋白之不存在。BMD亦由肌萎縮蛋白基因之突變引起，但此等突變維持開放閱讀框，產生半功能性肌萎縮蛋白，並導致通常溫和得多之表型及更長的壽命。
迄今為止，已有四種ASO經批准用於治療DMD：依特立生(eteplirsen)、戈洛迪森(golodirsen)、卡西莫森(casimersen)及維托拉森(viltolarsen)。然而，此等藥物之療效有限，並且每種藥物僅被批准用於治療一小部分DMD患者。
因此，仍然需要外顯子跳躍ASO以用於治療DMD之組成物及方法中。
本文提供用於治療DMD之組成物及方法中的ASO。本文提供之ASO與人類肌萎縮蛋白前驅mRNA之外顯子53之一部分反向互補。在一個實施例中，本文提供之ASO含有至少一個修飾，如本文所定義。在另一個實施例中，本文提供之ASO係具有硫代磷酸酯主鏈之2'-O-甲氧基乙基(「2'-MOE」) RNA寡核苷酸。在另一個實施例中，本文提供之ASO係具有硫代磷酸酯主鏈之2'-MOE RNA寡核苷酸，其中所有胞嘧啶均由5-甲基胞嘧啶置換，並且所有尿嘧啶均由胸腺嘧啶替代。在另一個實施例中，本文提供之ASO含有至少一個2'-OMe RNA核苷酸。在另一個實施例中，本文提供之ASO含有至少一個2'-F RNA核苷酸。在另一個實施例中，本文提供之ASO含有至少一個LNA核苷酸。
本文亦提供藉由投與本文提供之ASO或組成物來治療DMD之方法。本文亦提供藉由投與本文提供之ASO或組成物來延遲DMD發作之方法。
相關申請案
本申請案主張2023年5月5日提交之第63/500,503號及2024年1月23日提交之第63/623,904號美國臨時專利申請案的優先權。上文所提及之申請案之揭示內容以全文引用的方式併入本文中。 序列表
本申請案包含序列表，該序列表以名為「035107WO_SL.xml」之XML文件與本申請案一起提交，其創建於2024年4月26日，大小為19,194,860個位元組，以全文引用的方式併入本文。 i. 定義
為了便於理解本文闡述之揭示內容，以下定義多個術語。
除非另有定義，否則本文使用之所有技術及科學術語具有與普通熟習此項技術者通常理解之含義相同的含義。所有專利、申請案、已公佈之申請案及其他出版物均以引用方式全部併入本文。如果此處之術語有複數個定義，除非另有說明，否則以本節中之定義為準。
除非上下文另有明確規定，否則單數形式「一(個/種)(a/an)」及「該(the)」包括複數個指示物。
如本文所用，「個體」為動物，諸如哺乳動物，包括人類，諸如患者。
如本文所用，生物活性係指化合物之活體內活性或在活體內投與化合物、組成物或其他混合物後產生的生理反應。因此，生物活性涵蓋此類化合物、組成物及混合物之治療效果及藥物動力學性能。可在經設計來測試此類活性之活體外系統中觀察生物活性。
如本文所用，化合物之醫藥學上可接受之衍生物包括但不限於其鹽、酯、烯醇醚、烯醇酯、縮醛、縮酮、原酸酯、半縮醛、半縮酮、酸、鹼、晶籠化合物、溶劑合物或水合物。此類衍生物可易於由熟習此項技術者使用此類衍生化之已知方法來製備。所產生之化合物可向動物或人類投與而無顯著毒性作用，並且具有醫藥活性或為前藥。醫藥學上可接受之鹽包括但不限於胺鹽，諸如但不限於N,N'-二芐基乙二胺、氯普魯卡因、膽鹼、氨、二乙醇胺及其他羥烷基胺、乙二胺、N-甲基葡糖胺、普魯卡因、N-芐基苯乙胺、1-對氯芐基-2-吡咯啶-1'-基甲基苯并咪唑、二乙胺及其他烷基胺、哌嗪及參(羥甲基)胺基甲烷；鹼金屬鹽，諸如但不限於鋰、鉀及鈉；鹼土金屬鹽，諸如但不限於鋇、鈣及鎂；過渡金屬鹽，諸如但不限於鋅；以及無機鹽，諸如但不限於磷酸氫二鈉及磷酸二鈉；並且亦包括但不限於無機酸鹽，諸如但不限於鹽酸鹽及硫酸鹽；及有機酸鹽，諸如但不限於乙酸鹽、乳酸鹽、蘋果酸鹽、酒石酸鹽、檸檬酸鹽、抗壞血酸鹽、琥珀酸鹽、丁酸鹽、戊酸鹽、甲磺酸鹽及反丁烯二酸鹽。醫藥學上可接受之酯包括但不限於酸性基團(包括但不限於羧酸、磷酸、次膦酸、磺酸、亞磺酸及硼酸)之烷基、烯基、炔基、芳基、芳烷基及環烷基酯。醫藥學上可接受之烯醇醚包括但不限於式C＝C(OR)之衍生物，其中R為烷基、烯基、炔基、芳基、芳烷基及環烷基。醫藥學上可接受之烯醇酯包括但不限於式C=C(OC(O)R)之衍生物，其中R為氫、烷基、烯基、炔基、芳基、芳烷基及環烷基。醫藥學上可接受之溶劑合物及水合物為化合物與一或多個溶劑或水分子，或1至約100，或1至約10，或1至約2、3或4個溶劑或水分子之複合物。
如本文所用，治療意謂疾病或病症之一或多種症狀得到改善或以其他方式經有益地改變之任何方式。治療亦涵蓋本文組成物之任何醫藥用途，諸如用於治療DMD之用途。
如本文所用，藉由投與特定化合物或醫藥組成物對特定病症之症狀的改善係指可歸因於或與化合物或醫藥組成物之投與相關的任何減輕，無論係永久的抑或暫時的、持久的抑或短暫的。
如本文所用，且除非另有說明，否則術語「控制(manage)」、「控制(managing)」及「控制(management)」涵蓋預防特定疾病或病症在已患有疾病或病症之個體中的複發，及/或延長患有疾病或病症之個體保持緩解之時間。此等術語涵蓋調節疾病或病症之閾值、發展及/或持續時間，或改變個體對疾病或病症之反應方式。
在部分係藉由其自左至右書寫之習知化學式來指定之情況下，其同樣涵蓋由自右至左書寫結構而得到的化學上相同之部分， 例如-CH 2O-等價於-OCH 2-。
除非另外說明，否則單獨或作為另一取代基之一部分的術語「烷基」意謂直鏈( 亦即，非支鏈)或支鏈飽和烴基，其可包括二價及多價基團，具有指定碳原子數( 亦即C 1-C 10意謂一至十個碳)。烷基之實例包括但不限於諸如以下基團：甲基、乙基、正丙基、異丙基、正丁基、第三丁基、異丁基、第二丁基；例如正戊基、正己基、正庚基、正辛基之同系物及異構物；及其類似物。
除非另外說明，否則單獨或作為另一取代基之一部分的術語「烯基」意謂具有一或多個碳-碳雙鍵之直鏈( 亦即，非支鏈)或支鏈烴基，其可包括二價及多價基團，具有指定碳原子數( 亦即C 1-C 10意謂一至十個碳)。烯基之實例包括但不限於乙烯基(vinyl)( 亦即，乙烯基(ethenyl))、2-丙烯基、巴豆基、2-異戊烯基、2-(丁二烯基)、2,4-戊二烯基、3-(1,4-戊二烯基)、以及高級同系物及異構物。
除非另外說明，否則單獨或作為另一取代基之一部分的術語「炔基」意謂具有一或多個碳-碳參鍵之直鏈( 亦即，非支鏈)或支鏈烴基，其可包括二價及多價基團，具有指定碳原子數( 亦即C 1-C 10意謂一至十個碳)。炔基之實例包括但不限於乙炔基、1-丙炔基及3-丙炔基、3-丁炔基、以及高級同系物及異構物。
單獨或作為另一取代基之一部分的術語「伸烷基」意謂衍生自烷基之二價基團，如藉由但不限於-CH 2CH 2CH 2CH 2-所例示。通常，烷基(或伸烷基)將具有1至24個碳原子，包括具有10個或更少碳原子之彼等基團。「低級烷基」或「低級伸烷基」為較短鏈之烷基或伸烷基，一般具有六個或更少碳原子。
術語「烷氧基」、「烷胺基」及「烷硫基」(或硫代烷氧基)以其習知含義使用，並且指代分別經由氧原子、胺基或硫原子連接至分子之其餘部分上的彼等烷基。
除非另外說明，否則單獨或與另一術語組合之術語「雜烷基」意謂直鏈或支鏈烴基，其由選自由O、N、P、Si及S組成之群的雜原子組成，且其中氮及硫原子可視情況經氧化，且氮原子可具有烷基取代基以滿足化合價及/或可視情況經四級化。雜原子O、N、P、Si及S可位於雜烷基之任何內部位置。實例包括但不限於-CH 2-CH 2-O-CH 3、-CH 2-CH 2-NH-CH 3、-CH 2-CH 2-N(CH 3)-CH 3、-CH 2-S-CH 2-CH 3、-CH 2-CH 2-S(O)-CH 3、-CH 2-CH 2-S(O) 2-CH 3、-CH=CH-O-CH 3、-CH 2-CH=N-OCH 3及-CH=CH-N(CH 3)-CH 3。至多兩個雜原子可為連續的，諸如像-CH 2-NH-OCH 3及-CH 2-O-Si(CH 3) 3。類似地，單獨或作為另一取代基之一部分的術語「伸雜烷基」意謂衍生自雜烷基之二價基團，如藉由但不限於-CH 2-CH 2-S-CH 2-CH 2-及-CH 2-S-CH 2-CH 2-NH-CH 2-所例示。對於伸烷基及伸雜烷基連接基，連接基之式之書寫方向不隱含連接基之取向。例如，式-C(O) 2R'-表示-C(O) 2R'-及-R'C(O) 2-兩者。
除非另外說明，否則單獨或與其他術語組合之術語「環烷基」及「雜環烷基」分別表示「烷基」及「雜烷基」之環狀形式，包括雙環、三環及橋聯雙環基團。此外，對於雜環烷基，雜原子可佔據雜環連接至分子之其餘部分上的位置。環烷基之實例包括但不限於環戊基、環己基、1-環己烯基、3-環己烯基、環庚基、降莰烷基、雙環[2.2.2]辛基及其類似物。雜環烷基之實例包括但不限於1-(1,2,5,6-四氫吡啶基)、1-哌啶基、2-哌啶基、3-哌啶基、4-嗎啉基、3-嗎啉基、四氫呋喃-2-基、四氫呋喃-3-基、四氫噻吩-2-基、四氫噻吩-3-基、1-哌嗪基、2-哌嗪基、1-氮雜雙環[2.2.2]辛基或2-氮雜雙環[2.2.2]辛基及其類似物。
除非另外說明，否則單獨或作為另一取代基之一部分的術語「鹵基」意謂氟、氯、溴或碘原子。此外，諸如「鹵烷基」之術語意在包括單鹵烷基及多鹵烷基。例如，術語「鹵基(C 1-C 4)烷基」意在包括但不限於三氟甲基、2,2,2-三氟乙基、4-氯丁基、3-溴丙基及其類似物。
除非另外說明，否則術語「芳基」意謂多不飽和芳族烴取代基，其可為單環或者稠合在一起或共價連接之多環(在一個實施例中，1至3個環)。術語「雜芳基」係指在環中含有一至四個選自N、O及S之雜原子的芳基，其中氮及硫原子視情況經氧化，且氮原子視情況經四級化。雜芳基可經由碳或雜原子連接至分子之其餘部分。芳基及雜芳基之非限制性實例包括苯基、1-萘基、2-萘基、4-聯苯基、1-吡咯基、2-吡咯基、3-吡咯基、3-吡唑基、2-咪唑基、4-咪唑基、吡嗪基、2-噁唑基、4-噁唑基、5-噁唑基、3-異噁唑基、4-異噁唑基、5-異噁唑基、2-噻唑基、4-噻唑基、5-噻唑基、2-呋喃基、3-呋喃基、2-噻吩基、3-噻吩基、2-吡啶基、3-吡啶基、4-吡啶基、2-嘧啶基、4-嘧啶基、5-苯并噻唑基、嘌呤基、2-苯并咪唑基、5-吲哚基、1-異喹啉基、5-異喹啉基、2-喹喔啉基、5-喹喔啉基、3-喹啉基及6-喹啉基。芳基及雜芳基環系統之取代基部分可選自本文所述之可接受之取代基部分之群。術語「雜芳基鎓(heteroarylium)」係指在一或多個雜原子上帶正電荷之雜芳基。
如本文所用，術語「側氧基」意謂與碳原子雙鍵鍵合之氧原子。
以上術語中之各者( 例如，「烷基」、「雜烷基」、「芳基」及「雜芳基」)意在包括所指示之基團的經取代及未經取代之形式。下文提供各類型基團之取代基部分之非限制性實例。
在一個實施例中，烷基、雜烷基、伸烷基、烯基、伸雜烷基、雜烯基、炔基、環烷基、雜環烷基、環烯基及雜環烯基之取代基部分選自氘、-OR'、=O、=NR'、=N-OR'、-NR'R"、-SR'、鹵基、-SiR'R"R"'、-OC(O)R'、-C(O)R'、-CO 2R'、-CONR'R"、-OC(O)NR'R"、-NR"C(O)R'、-NR'-C(O)NR"R"'、-NR"C(O) 2R'、-NR-C(NR'R"R'")=NR""、-NR-C(NR'R")=NR'"、-S(O)R'、-S(O) 2R'、-S(O) 2NR'R"、-NRSO 2R'、-NRSO2NR'R''、-CN及-NO 2，數目範圍為零至此類基團中之氫原子數。在一個實施例中，環烷基、雜環烷基、環烯基及雜環烯基之取代基部分亦包括經取代及未經取代之烷基、經取代及未經取代之烯基、及經取代及未經取代之炔基。在一個實施例中，R'、R"、R"'及R""各自獨立地為氫、經取代或未經取代之雜烷基、經取代或未經取代之環烷基、經取代或未經取代之雜環烷基、經取代或未經取代之芳基( 例如，經1-3個鹵素取代之芳基)、經取代或未經取代之烷基、烷氧基或硫代烷氧基、或芳基烷基。當本文所提供之化合物包括多於一個R基團時，例如，當存在此等基團中之多於一者時，各R基團獨立地選擇為各R'、R"、R'"及R""基團。當R'及R"連接至同一氮原子時，它們可與該氮原子組合以形成4員、5員、6員或7員環。例如，-NR'R"意在包括但不限於1-吡咯啶基及4-嗎啉基。自上文對取代基部分之討論，熟習此項技術者應理解，術語「烷基」意在包括以下基團，包括與除氫基團以外之基團結合的碳原子，諸如鹵烷基( 例如，-CF 3及-CH 2CF 3)及醯基(例如，-C(O)CH 3、-C(O)CF 3、-C(O)CH 2OCH 3及其類似物)。
在一個實施例中，芳基及雜芳基之取代基部分選自氘、鹵基、經取代及未經取代之烷基、經取代及未經取代之烯基、及經取代及未經取代之炔基、-OR'、-NR'R"、-SR'、-SiR'R"R"'、-OC(O)R'、-C(O)R'、-CO 2R'、-CONR'R"、-OC(O)NR'R"、-NR"C(O)R'、-NR'-C(O)NR"R"'、-NR"C(O) 2R'、-NR-C(NR'R"R'")=NR""、-NR-C(NR'R")=NR'"、-S(O)R'、-S(O) 2R'、-S(O) 2NR'R"、-NRSO 2R'、-CN、及-NO 2、-R'、-N 3、-CH(Ph) 2、氟(C 1-C 4)烷氧基及氟(C 1-C 4)烷基，數目範圍為零至芳族環系統上之總氫數；且其中，在一個實施例中，R'、R"、R"'及R""獨立地選自氫、經取代或未經取代之烷基、經取代或未經取代之雜烷基、經取代或未經取代之環烷基、經取代或未經取代之雜環烷基、經取代或未經取代之芳基、及經取代或未經取代之雜芳基。當本文所提供之化合物包括多於一個R基團時，例如，當存在此等基團中之多於一者時，各R基團獨立地選擇為各R'、R"、R'"及R""基團。
芳基或雜芳基環之相鄰原子上的兩個取代基部分可視情況形成式-Q'-C(O)-(CRR') q-Q''-之環，其中Q'及Q''獨立地為-NR-、-O-、-CRR'-或單鍵，且q為0至3之整數。替代地，芳基或雜芳基環之相鄰原子上的兩個取代基部分可視情況經式-A-(CH 2) r-B-之取代基替代，其中A及B獨立地為-CRR'-、-O-、-NR-、-S-、-S(O)-、-S(O) 2-、-S(O) 2NR'-或單鍵，且r為1至4之整數。如此形成之新環之單鍵之一可視情況經雙鍵替代。替代地，芳基或雜芳基環之相鄰原子上的兩個取代基部分可視情況經式-(CRR') s-X'-(CR''R''') d-之取代基替代，其中s及d獨立地為0至3之整數，且X'為-O-、-NR'-、-S-、-S(O)-、-S(O) 2-或-S(O) 2NR'-。在一個實施例中，取代基部分R、R'、R"及R'"獨立地選自氫、經取代或未經取代之烷基、經取代或未經取代之環烷基、經取代或未經取代之雜環烷基、經取代或未經取代之芳基、及經取代或未經取代之雜芳基。
如本文所用，術語「雜原子」或「環雜原子」意在包括氧(O)、氮(N)、硫(S)、磷(P)及矽(Si)。
如本文所用，前藥為以下化合物，其在活體內投與後藉由一或多個步驟或過程在生理條件下代謝或以其他方式經歷化學變化或者以其他方式轉化為化合物之生物、醫藥或治療活性形式。此外，前藥可在離體環境中藉由化學或生化方法轉化為化合物之生物、醫藥或治療活性形式。例如，前藥可在放置於具有合適的酶或化學試劑之經皮貼片儲集層中時轉化為本發明之化合物。
本文所提供之某些化合物可以未溶劑合形式以及溶劑合形式(包括水合形式)存在。一般而言，溶劑合形式等價於未溶劑合形式且涵蓋在本揭露之範疇內。本文所提供之某些化合物可以多種結晶或非晶形式存在。一般而言，所有實體形式關於本文所涵蓋之用途皆等價且意欲處於本揭露之範疇內。
本文所提供之某些化合物具有不對稱碳原子(光學中心)或雙鍵；外消旋物、非鏡像異構物、互變異構物、幾何異構物、及單獨異構物皆涵蓋在本揭露之範疇內。本文所提供之化合物不包括此項技術中已知為太不穩定以致於無法合成及/或分離的化合物。
本文所提供之化合物亦可在構成此類化合物之一或多個原子處含有非天然比例的原子同位素。例如，化合物可用放射性同位素(諸如像氚( 3H)、碘-125 ( 125I)或碳-14 ( 14C))進行放射性標記。本文所提供之化合物之所有同位素變化形式，無論是否具有放射性，皆涵蓋在本揭露之範疇內。 II. 用於組成物及方法中之反義寡核苷酸
在一個實施例中，本文提供與人類肌萎縮蛋白前驅mRNA之外顯子53之一部分反向互補的ASO。在一個實施例中，本文提供之ASO具有或含有以下序列之一：
SEQ ID NO: 鹼基(5'至3')
1 TAAATGCTAGTCTGGAGG
2 GTAGTAAATGCTAGTCTG
3 ATATAGTAGTAAATGCTA
4 TAAATATATAGTAGTAAA
5 AAAAATAAATATATAGTA
6 AAAGGAAAAATAAATATA
7 GAATAAAAGGAAAAATAA
8 AACTAGAATAAAAGGAAA
9 CTTTCAACTAGAATAAAA
10 GAATTCTTTCAACTAGAA
11 ATTCTGAATTCTTTCAAC
12 CACTGATTCTGAATTCTT
13 CATCCCACTGATTCTGAA
14 TACTTCATCCCACTGATT
15 TCTTGTACTTCATCCCAC
16 GGTGTTCTTGTACTTCAT
17 CTGAAGGTGTTCTTGTAC
18 CGGTTCTGAAGGTGTTCT
19 GCCTCCGGTTCTGAAGGT
20 CTGTTGCCTCCGGTTCTG
21 TTCAACTGTTGCCTCCGG
22 TTTCATTCAACTGTTGCC
23 TAACATTTCATTCAACTG
24 TCCTTTAACATTTCATTC
25 TTGAATCCTTTAACATTT
26 TTGTGTTGAATCCTTTAA
27 AGCCATTGTGTTGAATCC
28 CTTCCAGCCATTGTGTTG
29 CTTAGCTTCCAGCCATTG
30 TCTTCCTTAGCTTCCAGC
31 CAGCTTCTTCCTTAGCTT
32 CTGCTCAGCTTCTTCCTT
33 AAGACCTGCTCAGCTTCT
34 GTCCTAAGACCTGCTCAG
35 GGCCTGTCCTAAGACCTG
36 GCTCTGGCCTGTCCTAAG
37 GCTTGGCTCTGGCCTGTC
38 CTCAAGCTTGGCTCTGGC
39 CATGACTCAAGCTTGGCT
40 CCTTCCATGACTCAAGCT
41 ACCCTCCTTCCATGACTC
42 TAGGGACCCTCCTTCCAT
43 CTGTATAGGGACCCTCCT
44 ATCTACTGTATAGGGACC
45 ATTGCATCTACTGTATAG
46 TTTGGATTGCATCTACTG
47 TTTCTTTTGGATTGCATC
48 GTGATTTTCTTTTGGATT
49 TTTCTGTGATTTTCTTTT
50 CTTGGTTTCTGTGATTTT
51 CTAACCTTGGTTTCTGTG
52 TGATACTAACCTTGGTTT
53 ATCTTTGATACTAACCTT
54 AAGGTATCTTTGATACTA
55 TTAAAAAGGTATCTTTGA
56 TTATTTTAAAAAGGTATC
57 GTATTTTATTTTAAAAAG
58 AACCAGTATTTTATTTTA
59 AATGTAACCAGTATTTTA
60 TATCAAATGTAACCAGTA
61 TGATTCTGAATTCTTTCA
62 CTGATTCTGAATTCTTTC
63 ACTGATTCTGAATTCTTT
64 CCACTGATTCTGAATTCT
65 CCCACTGATTCTGAATTC
66 TCCCACTGATTCTGAATT
67 ATCCCACTGATTCTGAAT
68 TCATCCCACTGATTCTGA
69 TTCATCCCACTGATTCTG
70 CTTCATCCCACTGATTCT
71 ACTTCATCCCACTGATTC
72 GTACTTCATCCCACTGAT
73 TGTACTTCATCCCACTGA
74 TTGTACTTCATCCCACTG
75 CTTGTACTTCATCCCACT
76 TTCTTGTACTTCATCCCA
77 GTTCTTGTACTTCATCCC
78 TGTTCTTGTACTTCATCC
79 GTGTTCTTGTACTTCATC
80 AGGTGTTCTTGTACTTCA
81 AAGGTGTTCTTGTACTTC
82 GAAGGTGTTCTTGTACTT
83 TGAAGGTGTTCTTGTACT
84 TCTGAAGGTGTTCTTGTA
85 TTCTGAAGGTGTTCTTGT
86 GTTCTGAAGGTGTTCTTG
87 GGTTCTGAAGGTGTTCTT
88 CCGGTTCTGAAGGTGTTC
89 TCCGGTTCTGAAGGTGTT
90 CTCCGGTTCTGAAGGTGT
91 CCTCCGGTTCTGAAGGTG
92 TGCCTCCGGTTCTGAAGG
93 TTGCCTCCGGTTCTGAAG
94 GTTGCCTCCGGTTCTGAA
95 TGTTGCCTCCGGTTCTGA
96 ACTGTTGCCTCCGGTTCT
97 AACTGTTGCCTCCGGTTC
98 CAACTGTTGCCTCCGGTT
99 TCAACTGTTGCCTCCGGT
100 ATTCAACTGTTGCCTCCG
101 CATTCAACTGTTGCCTCC
102 TCATTCAACTGTTGCCTC
103 TTCATTCAACTGTTGCCT
104 ATTTCATTCAACTGTTGC
105 CATTTCATTCAACTGTTG
106 ACATTTCATTCAACTGTT
107 GGTGTTCTTGTACT
108 TTCTTGTACTTCAT
109 TGTTCTTGTACTTC
110 GGTGTTCTTGTACTTC
111 TGTTCTTGTACTTCAT
112 GTGTTCTTGTACTTCA
113 GGTGTTCTTGTACTTCATCC
114 AAGGTGTTCTTGTACTTCAT
115 AGGTGTTCTTGTACTTCATC
116 AACATTTCATTCAACTGT
117 TTAACATTTCATTCAACT
118 TTTAACATTTCATTCAAC
119 CTTTAACATTTCATTCAA
120 CCTTTAACATTTCATTCA
121 ATTGTGTTGAATCCTTTA
122 CATTGTGTTGAATCCTTT
123 CCATTGTGTTGAATCCTT
124 GCCATTGTGTTGAATCCT
125 CAGCCATTGTGTTGAATC
126 CCAGCCATTGTGTTGAAT
127 TCCAGCCATTGTGTTGAA
128 TTCCAGCCATTGTGTTGA
129 GCTTCCAGCCATTGTGTT
130 AGCTTCCAGCCATTGTGT
131 TAGCTTCCAGCCATTGTG
132 TTAGCTTCCAGCCATTGT
133 CCTTAGCTTCCAGCCATT
134 TCCTTAGCTTCCAGCCAT
135 TTCCTTAGCTTCCAGCCA
136 CTTCCTTAGCTTCCAGCC
137 TTCTTCCTTAGCTTCCAG
138 CTTCTTCCTTAGCTTCCA
139 GCTTCTTCCTTAGCTTCC
140 AGCTTCTTCCTTAGCTTC
141 GTTTCTGTGATTTTCTTT
142 GGTTTCTGTGATTTTCTT
143 TGGTTTCTGTGATTTTCT
144 TTGGTTTCTGTGATTTTC
145 CCTTGGTTTCTGTGATTT
146 ACCTTGGTTTCTGTGATT
147 AACCTTGGTTTCTGTGAT
148 TAACCTTGGTTTCTGTGA
149 TTGATACTAACCTTGGTT
150 TTTGATACTAACCTTGGT
151 CTTTGATACTAACCTTGG
152 TCTTTGATACTAACCTTG
153 TATCTTTGATACTAACCT
154 GTATCTTTGATACTAACC
155 GGTATCTTTGATACTAAC
156 AGGTATCTTTGATACTAA
157 CCATGACTCAAGCTTGGC
158 TCCATGACTCAAGCTTGG
159 TTCCATGACTCAAGCTTG
160 CTTCCATGACTCAAGCTT
161 TCCTTCCATGACTCAAGC
162 CTCCTTCCATGACTCAAG
163 CCTCCTTCCATGACTCAA
164 CCCTCCTTCCATGACTCA
165 GACCCTCCTTCCATGACT
166 GGACCCTCCTTCCATGAC
167 GGGACCCTCCTTCCATGA
168 AGGGACCCTCCTTCCATG
169 TGTACTTCATCCCA
170 TTGTACTTCATCCC
171 CTTGTACTTCATCC
172 TCTTGTACTTCATC
173 GTTCTTGTACTTCA
174 GTGTTCTTGTACTT
175 AGGTGTTCTTGTAC
176 AAGGTGTTCTTGTA
177 TTGTACTTCATCCCA
178 CTTGTACTTCATCCC
179 TCTTGTACTTCATCC
180 TTCTTGTACTTCATC
181 GTTCTTGTACTTCAT
182 TGTTCTTGTACTTCA
183 GTGTTCTTGTACTTC
184 GGTGTTCTTGTACTT
185 AGGTGTTCTTGTACT
186 AAGGTGTTCTTGTAC
187 CTTGTACTTCATCCCA
188 TCTTGTACTTCATCCC
189 TTCTTGTACTTCATCC
190 GTTCTTGTACTTCATC
191 AGGTGTTCTTGTACTT
192 AAGGTGTTCTTGTACT
193 TCTTGTACTTCATCCCA
194 TTCTTGTACTTCATCCC
195 GTTCTTGTACTTCATCC
196 TGTTCTTGTACTTCATC
197 GTGTTCTTGTACTTCAT
198 GGTGTTCTTGTACTTCA
199 AGGTGTTCTTGTACTTC
200 AAGGTGTTCTTGTACTT
201 GTTCTTGTACTTCATCCCA
202 TGTTCTTGTACTTCATCCC
203 GTGTTCTTGTACTTCATCC
204 GGTGTTCTTGTACTTCATC
205 AGGTGTTCTTGTACTTCAT
206 AAGGTGTTCTTGTACTTCA
207 TGTTCTTGTACTTCATCCCA
208 GTGTTCTTGTACTTCATCCC
209 AGCCATTGTGTTGAATCCTGTTCTTGTACTTCATCC
210 TGTTCTTGTACTTCATCCAGCCATTGTGTTGAATCC
211 CCATTGTGTTGAATCCGTTCTTGTACTTCATC
212 GTTCTTGTACTTCATCCCATTGTGTTGAATCC
213 ATTGTGTTGAATCCGTTCTTGTACTTCA
214 GTTCTTGTACTTCAATTGTGTTGAATCC
215 TCTTGTACTTCATGTGTTGAATCC
216 TCTTGTACTTCATTGTGTTGAATC
217 TCTTGTACTTCAATTCAACACAAT
218 TTCTTGTACTTCTGTGTTGAATCC
219 TTCTTGTACTTCTTGTGTTGAATC
220 TTCTTGTACTTCATTCAACACAAT
221 GTTCTTGTACTTTGTGTTGAATCC
222 GTTCTTGTACTTTTGTGTTGAATC
223 GTTCTTGTACTTATTCAACACAAT
224 TGTGTTGAATCCTCTTGTACTTCA
225 TGTGTTGAATCCTTCTTGTACTTC
226 TGTGTTGAATCCGTTCTTGTACTT
227 TTGTGTTGAATCTCTTGTACTTCA
228 TTGTGTTGAATCTTCTTGTACTTC
229 TTGTGTTGAATCGTTCTTGTACTT
230 ATTCAACACAATTCTTGTACTTCA
231 TGTTCTUGTACTTCATCC
232 TGTTCTUGUACUUCATCC
233 TCATCCCACTGATT
234 TCATCCCACTGATTCT
235 TCATCCCACTGATTCTGAAT
236 TCATCCCACTGATTCTGAATTC
237 CCCACTGATTCTGA
238 ATCCCACTGATTCTGA
239 CTTCATCCCACTGATTCTGA
240 TACTTCATCCCACTGATTCTGA
241 ATCCCACTGATTCT
242 CATCCCACTGATTCTG
243 TTCATCCCACTGATTCTGAA
244 CTTCATCCCACTGATTCTGAAT
245 TCTTTCAACTAGAATAAA
246 TTCTTTCAACTAGAATAA
247 ATTCTTTCAACTAGAATA
248 AATTCTTTCAACTAGAAT
249 TGAATTCTTTCAACTAGA
250 CTGAATTCTTTCAACTAG
251 TCTGAATTCTTTCAACTA
252 TTCTGAATTCTTTCAACT
253 GATTCTGAATTCTTTCAA
254 TCAUCCCACUGAUUCUGA
255 UUCUUGUACUUCAUCCCA
256 GUUCUUGUACUUCAUCCC
257 UGUUCUUGUACUUCAUCC
258 TGUUCUUGUACUUCAUCC
259 GUGUUCUUGUACUUCAUC
260 GTGUUCUUGUACUUCATC
261 GGUGUUCUUGUACUUCAU
262 AGGUGUUCUUGUACUUCA
263 AGCCAUUGUGUUGAAUCC
264 TGTUCUUGUACUUCATCC
265 AATTCTTTCAACTAG
266 TCTGAATTCTTTCAAC
267 TCTGAATTCTTTCAA
268 CTGAATTCTTTCAAC
269 TGAATTCTTTCAACT
270 ATTCTTTCAACTAGA
271 TCTGAATTCTTTCAACT
272 CTGAATTCTTTCAACTA
273 TGAATTCTTTCAACTAG
274 GAATTCTTTCAACTAGA
275 TCTGAATTCTTTCAACTAGA
276 TCTGAATTCTTTCAACTAG
277 CTGAATTCTTTCAACTAGA
278 CTGAATTCTTTCAACTAGAA
279 TTCTGAATTCTTTCAACTAG
280 TGTUCUUGUACUUCAUCC
281 TGUTCUUGUACUUCAUCC
282 TGUUCTUGUACUUCAUCC
283 TGUUCUTGUACUUCAUCC
284 TGUUCUUGTACUUCAUCC
285 TGUUCUUGUACTUCAUCC
286 TGUUCUUGUACUTCAUCC
287 TGUUCUUGUACUUCATCC
288 TGTTCUUGUACUUCATCC
289 TGTTCTUGUACUTCATCC
290 TGTTCTTGUACTTCATCC
291 UGUUCUUGTACUUCAUCC
292 GGTGTTCTTGUACTTC
293 TGTTCTTGUACTTCAT
294 TCUGAAUUCUUUCAACUAGA
295 CTGAATTCTTTCAACT
296 TGAATTCTTTCAACTA
297 GAATTCTTTCAACTAG
298 AATTCTTTCAACTAGA
299 CUGAAUUCUUUCAACUAG
300 CTGAAUUCUUUCAACUAG
301 UCUGAAUUCUUUCAACUAGA
302 CUGAATTCTTTCAACTAG
303 CTGAATTCTUUCAACTAG
304 CUGAATTCTUUCAACTAG
305 CUGAAUUCUUUCAACTAG
306 CTGAAUUCTTTCAACTAG
307 CTGAATUCTTTCAACTAG
308 AATTCTTTCAACUAG
309 AAUUCUUUCAACUAG
310 AATUCUUUCAACUAG
311 AAUUCUUUCAACTAG
312 CUGAATTCTTTCAACUAG
313 CUGAAUTCTTTCAACUAG
314 CUGAAUUCTTTCAACUAG
315 CUGAAUUCTTUCAACUAG
316 CTGAATUCUTUCAACTAG
317 CUGAAUTCTUTCAACUAG
318 CUGAAUTCUUTCAACTAG
319 CUGAATUCUTTCAACTAG
320 CTGAATTCUUTCAACTAG
321 CTGAATTCUUUCAACTAG
322 CTGAATUCUUUCAACTAG
323 CTGAAUUCUUUCAACTAG
324 ATTCTGAATTCTTTCAACT
325 GATTCTGAATTCTTTCAACT
326 TGATTCTGAATTCTTTCAACT
327 CTGATTCTGAATTCTTTCAACT
328 GATTCTGAATTCTTTCAAC
329 TGATTCTGAATTCTTTCAAC
330 CTGATTCTGAATTCTTTCAAC
331 ACTGATTCTGAATTCTTTCAAC
在另一個實施例中，本文提供之ASO具有或含有本文提供之序列之一，其中所有核苷酸均為RNA。在另一個實施例中，本文提供之ASO具有或含有本文提供之序列之一，其中所有核苷酸均為DNA。在另一個實施例中，本文提供之ASO具有或含有本文提供之序列之一，其中核苷酸為RNA與DNA之混合物。
如熟習此項技術者所知，天然存在之寡核苷酸通常含有核苷酸，其含有糖部分及鹼基部分，它們藉由磷酸二酯主鏈連接。在一個實施例中，本文提供之ASO含有修飾。修飾為ASO中一或多個核苷酸之糖部分或鹼基部分之化學修飾，或為磷酸二酯主鏈之化學修飾。可獨立地選擇每個修飾。因此，本文提供之ASO可具有兩個或更多個不同修飾。
在一個實施例中，修飾為ASO中一或多個核苷酸之糖部分之化學修飾。在另一個實施例中，修飾為ASO中1、2、3、4個或所有核苷酸之糖部分之化學修飾。
在一個實施例中，用於本文提供之ASO中的經修飾之糖部分為2'-O-修飾之RNA，諸如2'-O-烷基或2'-O-(經取代)烷基，例如2'-O-甲基、2'-O-(2-氰基乙基)、2'-O-(2-甲氧基)乙基(2'-MOE)、2'-O-(2-硫基甲基)乙基、2'-O-丁醯基、2'-O-炔丙基、2'-O-縮醛酯(例如Biscans等人Bioorg. Med. Chem. 2015, 23, 5360)、2'-O-烯丙基、2'-O-(2S-甲氧基丙基)、2'-O-(N-(胺乙基)胺甲醯基)甲基) (2'-AECM)、2'-O-(2-羧乙基)及胺甲醯基衍生物(Yamada等人 Org. Biomol. Chem. 2014, 12, 6457)、2'-O-(2-胺基)丙基、2'-O-(2-(二甲胺基)丙基)、2'-O-(2-胺基)乙基、2'-O-(2-(二甲胺基)乙基)、2'-O-(鹵烷氧基)甲基(Arai K.等人 Bioorg. Med. Chem. 2011, 21, 6285)，例如2'-O-(2-氯乙氧基)甲基(MCEM)、2'-O-(2,2-二氯乙氧基)甲基(DCEM)；2'-O-烷氧羰基，例如2'-O-[2-(甲氧羰基)乙基] (MOCE)、2'-O-[2-(N-甲基胺甲醯基)乙基] (MCE)、2'-O-[2-(N,N-二甲基胺甲醯基)乙基] (DCME)、2'-O-[2-(甲硫基)乙基] (2'-MTE)、2'-(ω-O-絲胺醇)；2'-鹵基，例如2'-F、FANA (2'-F阿拉伯糖基核酸)；2',4'-二氟-2'-去氧；碳環糖及氮雜糖修飾；3'-O-取代，例如3'-O-甲基、3'-O-丁醯基、3'-O-炔丙基；4'-取代，例如4'-胺甲基-2'-O-甲基或4'-胺甲基-2'-氟；5'-取代，例如5'-甲基或CNA (Ostergaard等人, ACS Chem. Biol. 2014, 22, 6227)；及其衍生物。
在一個實施例中，2'-取代之RNA為2'-F、2'-O-甲基或2'-O-(2-甲氧基乙基)(亦即，2'-MOE)取代的。在另一個實施例中，2'-取代之RNA為2'-MOE取代的。
在一個實施例中，用於本文提供之ASO中的經修飾之糖部分係如此之修飾，該修飾增加對靶標股之結合親和力，及/或增加所得到的該第一及/或第二寡核苷酸與其靶標之雙鏈體之解鏈溫度，及/或降低免疫刺激作用，及/或增加生物穩定性，及/或改善生物分佈及/或組織內分佈，及/或改善細胞攝取及運輸。
在一個實施例中，用於本文提供之ASO中的經修飾之糖部分為雙環核酸(BNA)單體。在一個實施例中，BNA為戊糖衍生之部分，其已經化學改變以在構形上限制戊糖環。用於本文提供之ASO中的BNA之非限制性實例係以下BNA：第一環(諸如戊糖環)與另一個環狀部分形成螺烷以使兩個環僅共享一個原子的BNA；第一環(諸如戊糖環)與另一個環狀部分稠合以使得兩個環共享兩個相鄰原子的BNA；以及第一環(諸如戊糖環)經由一個部分來形成橋聯化合物的BNA，該部分在兩個不相鄰原子處連接至第一環狀部分。此類不相鄰原子係稱為橋頭原子。橋聯化合物包含多個環，該等環各自至少重疊三個原子。相反，具有兩個環之化合物(其中彼等環僅在兩個原子上重疊)為稠合化合物。在一些橋聯化合物中，兩個橋頭原子之間的最小連接係稱為橋聯部分，或稱為橋部分。在其他橋聯化合物中，當一個環為核苷酸之特徵環諸如戊糖環時，不構成該特徵環之部分係稱為橋聯部分。由此可見，橋聯雙環化合物之命名係上下文相關的。
雙環化合物可包含額外環。雙環化合物包含至少兩個環，並且該等兩個環構成螺烷、稠合系統或橋聯系統或其組合。在一個實施例中，雙環化合物為稠合及橋聯化合物。在一些實施例中，BNA為橋聯核酸單體。
在一個實施例中，提供一種ASO，其中ASO中的BNA在每次出現時獨立地選自由以下各物組成之群：構形限制性核苷酸(CRN)單體、鎖核酸(LNA)單體、木糖-LNA單體、α-LNA單體、α-L-LNA單體、β-D-LNA單體、2'-胺基-LNA單體、2'-(烷胺基)-LNA單體、2'-(醯基胺基)-LNA單體、2'-N-取代-2'-胺基-LNA單體、2'-硫代-LNA單體、(2'-O,4'-C)受限之乙基(cEt) BNA單體、(2'-O,4'-C)受限之甲氧基乙基(cMOE) BNA單體、2',4'-BNANC(N-H)單體、2',4'-BNANC(N-Me)單體、2',4'-BNANC(N-Bn)單體、乙烯橋聯核酸(ENA)單體、碳環LNA (cLNA)單體、3,4-二氫-2H-哌喃核酸(DpNA)單體、2'-C-橋聯雙環核苷酸(CBBN)單體、雜環橋聯BNA單體、醯胺基橋聯BNA單體、脲橋聯BNA單體、磺醯胺橋聯BNA單體、雙環碳環核苷酸單體、TriNA單體、α-L-TriNA單體、雙環DNA (bcDNA)單體、F-bcDNA單體、三環DNA (tcDNA)單體、F-tcDNA單體、氧雜環丁烷核苷酸單體、衍生自2'-胺基-LNA之鎖PMO單體及其衍生物。在一個實施例中，可在該寡核苷酸中使用多於一種不同支架BNA修飾。在一些實施例中，BNA在每次出現時獨立地選自由以下各物組成之群：構形受限之核苷酸(CRN)單體、鎖核酸(LNA)單體、木糖-LNA單體、α-L-LNA單體、β-D-LNA單體、2'-胺基-LNA單體、2'-(烷胺基)-LNA單體、2'-(醯基胺基)-LNA單體、2'-N-取代-2'-胺基-LNA單體、(2'-O,4'-C)受限之乙基(cEt) LNA單體、(2'-O,4'-C)受限之甲氧基乙基(cMOE) BNA單體、2',4'-BNANC(N-H)單體、2',4'-BNANC(N-Me)單體、乙烯橋聯核酸(ENA)單體、2'-C橋聯雙環核苷酸(CBBN)單體及其衍生物。
在一個實施例中，BNA在每次出現時為鎖核酸(LNA)單體。在另一個實施例中，本文提供之ASO含有LNA及2'-MOE單體。在另一個實施例中，本文提供之ASO含有1-4個LNA單體。在另一個實施例中，本文提供之ASO含有1-3個LNA單體。在另一個實施例中，本文提供之ASO含有1或2個LNA單體。在另一個實施例中，本文提供之ASO含有1、2、3或4個LNA單體。在另一個實施例中，本文提供之ASO含有一個LNA單體。在另一個實施例中，本文提供之ASO含有兩個LNA單體。在另一個實施例中，本文提供之ASO含有三個LNA單體。在另一個實施例中，本文提供之ASO含有四個LNA單體。在另一個實施例中，本文提供之ASO在ASO之兩個5'末端核苷酸位置處含有兩個LNA單體，並且在ASO之兩個3'末端核苷酸位置處含有兩個LNA單體。
此等BNA之結構實例如下所示，其中B為核苷酸鹼基(例如A、G、T、C、5-甲基胞嘧啶等)，X為變數且表示O、S或NR，其中R為H或烷基，X 2為羥基部分或如本文所定義之另一2'-取代，並且L為如本文所述之主鏈鍵聯。如熟習此項技術者所知，文獻中此類修飾之命名通常為任意的並且不遵循統一約定－在本申請案中，以下提供之名稱意欲指代以下提供之結構。為了比較，首先顯示習知RNA單體之環狀支架。在下面所示之結構中，單體通常描述為3'-末端單體。當未指明對掌性時，每個鏡像異構物係單獨提及的。環狀部分中包含之雜原子可由例如N、O或S之其他雜原子替代。 衍生自2'-胺基-LNA之鎖PMO (此處，主鏈經由N而非3'-O延伸)
在另一個實施例中，用於本文之BNA包括cEt (2'-O,4'-C受限乙基) LNA (doi: 10.1021/ja710342q)、cMOE (2'-O,4'-C受限甲氧基乙基) LNA (Seth等人J. Org. Chem. 2010, 75, 1569–1581)、2',4'-BNANC(N-H)、2',4'-BNANC(N-Me)、乙烯橋聯核酸(ENA) (doi: 10.1093/nass/1.1.241)、碳環LNA (cLNA) (doi: 10.1021/jo100170g)、DpNA (Osawa等人，J. Org. Chem., 2015, 80 (21), 第10474–10481頁)、2'-C-橋聯雙環核苷酸(CBBN，例如WO 2014/145356 (MiRagen Therapeutics))、雜環橋聯LNA (例如WO 2014/126229 (Mitsuoka Y等人))、醯胺基橋聯LNA (例如Yamamoto等人Org. Biomol. Chem. 2015, 13, 3757)、脲橋聯LNA (例如Nishida等人Chem. Commun. 2010, 46, 5283)，磺醯胺橋聯LNA (例如WO 2014/112463 (Obika S等人))、雙環碳環核苷(例如WO 2015/142910(Ionis Pharmaceuticals))、TriNA (Hanessian等人，J. Org. Chem., 2013, 78 (18), 第9064–9075頁)、α-L-TriNA、雙環DNA (bcDNA) (Bolli等人，Chem Biol. 1996 Mar;3(3):197-206)、F-bcDNA (DOI: 10.1021/jo402690j)、三環DNA(tcDNA) (Murray等人，Nucl. Acids Res., 2012, 第40卷, 第13期 6135–6143)、F-tcDNA (doi: 10.1021/acs.joc.5b00184)、或氧雜環丁烷核苷酸單體(Nucleic Acids Res. 2004, 32, 5791–5799)。在其他實施例中，用於本文之BNA包括在WO 2011/097641 (ISIS/Ionis Pharmaceuticals)及WO 2016/017422 (Osaka University)中揭示之彼等。
在另一個實施例中，本文提供之ASO中一或多個核苷酸之糖部分之化學修飾涉及用另一個化學部分替代糖。在此等實施例中，糖部分由以下各物替代：例如嗎啉(PMO、PPMO、PMO-X)、肽衍生物(PNA)、硼簇修飾之PNA、基於吡咯啶之氧肽核酸(POPNA)、基於甘醇或甘油之核酸(GNA)、基於蘇糖之核酸(TNA)、基於無環蘇胺醇之核酸(aTNA)、基於陽離子N-嗎啉基之寡聚物(PMOPlus)、具有整合鹼基及主鏈之寡核苷酸(ONIB)、吡咯啶-醯胺寡核苷酸(POM)；及其衍生物。
在一個實施例中，修飾為ASO中一或多個核苷酸之鹼基部分之化學修飾。在另一個實施例中，修飾為ASO中1、2、3、4個或所有核苷酸之鹼基部分之化學修飾。
在一個實施例中，本文提供之ASO含有至少一個經修飾之鹼基部分。在另一個實施例中，本文提供之ASO之所有鹼基部分均經修飾。在另一個實施例中，本文提供之ASO具有或含有本文提供之序列之一，其中至少一個胸腺嘧啶鹼基為尿嘧啶。在另一個實施例中，本文提供之ASO具有或含有本文提供之序列之一，其中所有胸腺嘧啶鹼基均為尿嘧啶。在另一個實施例中，本文提供之ASO具有或含有本文提供之序列之一，其中至少一個胞嘧啶鹼基為5-甲基胞嘧啶。在另一個實施例中，本文提供之ASO具有或含有本文提供之序列之一，其中所有胞嘧啶鹼基均為5-甲基胞嘧啶。在另一個實施例中，本文提供之ASO具有或含有本文提供之序列之一，其中所有胸腺嘧啶鹼基均為尿嘧啶且所有胞嘧啶鹼基均為5-甲基胞嘧啶。
在一個實施例中，修飾為ASO主鏈之化學修飾。在另一個實施例中，修飾為ASO主鏈之化學修飾，其中ASO中之1、2、3、4個或所有磷酸二酯鍵聯均經修飾。在另一個實施例中，本文提供之ASO具有至少一個硫代磷酸酯主鏈鍵聯。在另一個實施例中，本文提供之ASO具有完全硫代磷酸酯主鏈鍵聯。在另一個實施例中，本文提供之ASO具有硫代磷酸酯與磷酸酯主鏈鍵聯之混合物。在另一個實施例中，本文提供之ASO具有至少一個二胺基磷酸酯主鏈鍵聯。在另一個實施例中，本文提供之ASO具有完全二胺基磷酸酯主鏈鍵聯。在另一個實施例中，本文提供之ASO具有二胺基磷酸酯與磷酸酯主鏈鍵聯之混合物。
在另一個實施例中，本文提供之ASO中的主鏈為對掌性純的硫代磷酸酯、二硫代磷酸酯(PS2)、膦醯基乙酸酯(PACE)、膦醯基乙醯胺(PACA)、硫代膦醯基乙酸酯、硫代膦醯基乙醯胺、硫代磷酸酯前藥、H-膦酸酯、膦酸甲酯、硫代膦酸甲酯、磷酸甲酯、硫代磷酸甲酯、磷酸乙酯、硫代磷酸乙酯、硼磷酸酯、硫代硼磷酸酯、硼磷酸甲酯、硫代硼磷酸甲酯、硼膦酸甲酯、硫代硼膦酸甲酯及其衍生物。另一修飾包括亞磷醯胺、胺基磷酸酯、N3'→P5'胺基磷酸酯、二胺基磷酸酯、硫代二胺基磷酸酯、胺基磺酸酯、二亞甲基亞碸、磺酸酯、三唑、草醯基、胺基甲酸酯、亞甲基亞胺基(MMI)、3'-S-硫醇式磷酸酯及硫代乙醯胺基核酸(TANA)；及其衍生物。
在一個實施例中，本文提供之ASO含有羥基烷氧基。用於本文提供之ASO中的羥基烷氧基包含以下或由以下組成：乙二醇單體、乙二醇寡聚物或乙二醇聚合物(亦稱為聚乙二醇，PEG)。
在另一個實施例中，用於本文提供之組成物及方法中的反義寡核苷酸選自下表。此表使用熟習此項技術者熟知的用於大分子之標準分層編輯語言(HELM)。簡而言之，HELM係一種描述複雜生物分子的方法。它係一種機器可讀之符號，用於呈現肽、蛋白質、寡核苷酸及相關小分子連接子之組成及結構。參見例如Zhang等人, J. Chem. Inf. Model. 2012, 52, 10, 2796-2806, pubs.acs.org/doi/10.1021/ci3001925; www.pistoiaalliance.org/helm-notation/。
SEQ ID NO: 鹼基(5'至3')
332 RNA1{[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](G)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)}$$$$V2.0
333 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)}$$$$V2.0
334 RNA1{[moe](A)[sp].[moe](T)[sp].[moe](A)[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)}$$$$V2.0
335 RNA1{[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](A)[sp].[moe](T)[sp].[moe](A)[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe](A)}$$$$V2.0
336 RNA1{[moe](A)[sp].[moe](A)[sp].[moe](A)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](A)[sp].[moe](T)[sp].[moe](A)[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)}$$$$V2.0
337 RNA1{[moe](A)[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](A)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](A)[sp].[moe](T)[sp].[moe](A)}$$$$V2.0
338 RNA1{[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](A)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)}$$$$V2.0
339 RNA1{[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](A)}$$$$V2.0
340 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe](A)[sp].[moe](A)}$$$$V2.0
341 RNA1{[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)}$$$$V2.0
342 RNA1{[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])}$$$$V2.0
343 RNA1{[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)}$$$$V2.0
344 RNA1{[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)}$$$$V2.0
345 RNA1{[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)}$$$$V2.0
346 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])}$$$$V2.0
347 RNA1{[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
348 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])}$$$$V2.0
349 RNA1{[moe]([m5C])[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)}$$$$V2.0
350 RNA1{[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)}$$$$V2.0
351 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)}$$$$V2.0
352 RNA1{[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](G)[sp].[moe](G)}$$$$V2.0
353 RNA1{[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
354 RNA1{[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)}$$$$V2.0
355 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
356 RNA1{[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)}$$$$V2.0
357 RNA1{[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)}$$$$V2.0
358 RNA1{[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
359 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)}$$$$V2.0
360 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)}$$$$V2.0
361 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])}$$$$V2.0
362 RNA1{[moe]([m5C])[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)}$$$$V2.0
363 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)}$$$$V2.0
364 RNA1{[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)}$$$$V2.0
365 RNA1{[moe](G)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
366 RNA1{[moe](G)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)}$$$$V2.0
367 RNA1{[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
368 RNA1{[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
369 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](G)[sp].[moe]([m5C])}$$$$V2.0
370 RNA1{[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](T)}$$$$V2.0
371 RNA1{[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](T)}$$$$V2.0
372 RNA1{[moe](A)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
373 RNA1{[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](G)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
374 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](G)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)}$$$$V2.0
375 RNA1{[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](G)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
376 RNA1{[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
377 RNA1{[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)}$$$$V2.0
378 RNA1{[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
379 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)}$$$$V2.0
380 RNA1{[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)}$$$$V2.0
381 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)}$$$$V2.0
382 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)}$$$$V2.0
383 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)}$$$$V2.0
384 RNA1{[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)}$$$$V2.0
385 RNA1{[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)}$$$$V2.0
386 RNA1{[moe](T)[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe](A)[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)}$$$$V2.0
387 RNA1{[moe](T)[sp].[moe](T)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe](A)[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
388 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe](A)[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
389 RNA1{[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](A)}$$$$V2.0
390 RNA1{[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](A)}$$$$V2.0
391 RNA1{[moe](T)[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)}$$$$V2.0
392 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
393 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
394 RNA1{[lna](A)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna](T)}$$$$V2.0
395 RNA1{[lna]([m5C])[sp].[lna](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](T)}$$$$V2.0
396 RNA1{[lna]([m5C])[sp].[lna]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](T)}$$$$V2.0
397 RNA1{[lna]([m5C])[sp].[lna]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
398 RNA1{[lna](T)[sp].[lna]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[lna](T)[sp].[lna](T)}$$$$V2.0
399 RNA1{[lna](A)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
400 RNA1{[lna]([m5C])[sp].[lna](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[lna](A)[sp].[lna](A)}$$$$V2.0
401 RNA1{[lna](T)[sp].[lna]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](G)[sp].[lna](A)}$$$$V2.0
402 RNA1{[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](G)}$$$$V2.0
403 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](T)}$$$$V2.0
404 RNA1{[lna](A)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
405 RNA1{[lna](T)[sp].[lna](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[lna](T)[sp].[lna](T)}$$$$V2.0
406 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
407 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](G)[sp].[lna](A)}$$$$V2.0
408 RNA1{[lna](T)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](G)}$$$$V2.0
409 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna]([m5C])[sp].[lna](T)}$$$$V2.0
410 RNA1{[lna](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna]([m5C])}$$$$V2.0
411 RNA1{[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
412 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
413 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
414 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
415 RNA1{[lna](G)[sp].[lna](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
416 RNA1{[lna](A)[sp].[lna](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
417 RNA1{[lna](A)[sp].[lna](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
418 RNA1{[lna](G)[sp].[lna](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](T)}$$$$V2.0
419 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[lna]([m5C])[sp].[lna](T)}$$$$V2.0
420 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[lna](A)[sp].[lna]([m5C])}$$$$V2.0
421 RNA1{[lna](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[lna](T)[sp].[lna](A)}$$$$V2.0
422 RNA1{[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna](G)[sp].[lna](T)}$$$$V2.0
423 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna](G)}$$$$V2.0
424 RNA1{[lna](G)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](T)}$$$$V2.0
425 RNA1{[lna]([m5C])[sp].[lna](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](T)}$$$$V2.0
426 RNA1{[lna]([m5C])[sp].[lna]([m5C])[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
427 RNA1{[lna](T)[sp].[lna]([m5C])[sp].[moe]([m5C])[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[lna](T)[sp].[lna](T)}$$$$V2.0
428 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[lna](G)[sp].[lna](T)}$$$$V2.0
429 RNA1{[lna]([m5C])[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[lna](T)[sp].[lna](G)}$$$$V2.0
430 RNA1{[lna](G)[sp].[lna]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[lna](G)[sp].[lna](T)}$$$$V2.0
431 RNA1{[lna](T)[sp].[lna](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[lna](G)[sp].[lna](G)}$$$$V2.0
432 RNA1{[lna](T)[sp].[lna](T)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[lna](A)[sp].[lna](G)}$$$$V2.0
433 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[lna](A)[sp].[lna](A)}$$$$V2.0
434 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](G)[sp].[lna](A)}$$$$V2.0
435 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](G)}$$$$V2.0
436 RNA1{[lna](A)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](T)}$$$$V2.0
437 RNA1{[lna](A)[sp].[lna](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
438 RNA1{[lna]([m5C])[sp].[lna](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](G)[sp].[moe](G)[sp].[lna](T)[sp].[lna](T)}$$$$V2.0
439 RNA1{[lna](T)[sp].[lna]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](G)[sp].[lna](G)[sp].[lna](T)}$$$$V2.0
440 RNA1{[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[lna](G)[sp].[lna](G)}$$$$V2.0
441 RNA1{[lna](A)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])[sp].[lna](G)}$$$$V2.0
442 RNA1{[lna]([m5C])[sp].[lna](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
443 RNA1{[lna](T)[sp].[lna]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
444 RNA1{[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe]([m5C])[sp].[lna]([m5C])[sp].[lna](T)}$$$$V2.0
445 RNA1{[lna](T)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
446 RNA1{[lna](A)[sp].[lna](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[lna](G)[sp].[lna]([m5C])}$$$$V2.0
447 RNA1{[lna]([m5C])[sp].[lna](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[lna](T)[sp].[lna](G)}$$$$V2.0
448 RNA1{[lna](A)[sp].[lna]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[lna](T)[sp].[lna](T)}$$$$V2.0
449 RNA1{[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)}$$$$V2.0
450 RNA1{[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
451 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
452 RNA1{[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
453 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
454 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)}$$$$V2.0
455 RNA1{[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
456 RNA1{[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
457 RNA1{[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
458 RNA1{[lna](G)[sp].[lna](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[lna]([m5C])[sp].[lna](T)}$$$$V2.0
459 RNA1{[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
460 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
461 RNA1{[lna](G)[sp].[lna](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
462 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
463 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
464 RNA1{[lna](G)[sp].[lna](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
465 RNA1{[lna](A)[sp].[lna](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
466 RNA1{[lna](A)[sp].[lna](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
467 RNA1{[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)}$$$$V2.0
468 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)}$$$$V2.0
469 RNA1{[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)}$$$$V2.0
470 RNA1{[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
471 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)}$$$$V2.0
472 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)}$$$$V2.0
473 RNA1{[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)}$$$$V2.0
474 RNA1{[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](G)}$$$$V2.0
475 RNA1{[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
476 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
477 RNA1{[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)}$$$$V2.0
478 RNA1{[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe]([m5C])}$$$$V2.0
479 RNA1{[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)}$$$$V2.0
480 RNA1{[moe](A)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)}$$$$V2.0
481 RNA1{[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)}$$$$V2.0
482 RNA1{[moe](T)[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)}$$$$V2.0
483 RNA1{[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])}$$$$V2.0
484 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)}$$$$V2.0
485 RNA1{[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)}$$$$V2.0
486 RNA1{[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](A)}$$$$V2.0
487 RNA1{[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)}$$$$V2.0
488 RNA1{[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)}$$$$V2.0
489 RNA1{[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)}$$$$V2.0
490 RNA1{[moe]([m5C])[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
491 RNA1{[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
492 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)}$$$$V2.0
493 RNA1{[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)}$$$$V2.0
494 RNA1{[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)}$$$$V2.0
495 RNA1{[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)}$$$$V2.0
496 RNA1{[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)}$$$$V2.0
497 RNA1{[moe](T)[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)}$$$$V2.0
498 RNA1{[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)}$$$$V2.0
499 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
500 RNA1{[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)}$$$$V2.0
501 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
502 RNA1{[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
503 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)}$$$$V2.0
504 RNA1{[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
505 RNA1{[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
506 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)}$$$$V2.0
507 RNA1{[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)}$$$$V2.0
508 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)}$$$$V2.0
509 RNA1{[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
510 RNA1{[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)}$$$$V2.0
511 RNA1{[moe](A)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)}$$$$V2.0
512 RNA1{[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
513 RNA1{[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)}$$$$V2.0
514 RNA1{[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)}$$$$V2.0
515 RNA1{[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)}$$$$V2.0
516 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](G)}$$$$V2.0
517 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)}$$$$V2.0
518 RNA1{[moe](T)[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)}$$$$V2.0
519 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
520 RNA1{[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])}$$$$V2.0
521 RNA1{[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)}$$$$V2.0
522 RNA1{[fl2r](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[fl2r]([m5C])}$$$$V2.0
523 RNA1{[fl2r](T)[sp].[fl2r](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r]([m5C])}$$$$V2.0
524 RNA1{[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r]([m5C])}$$$$V2.0
525 RNA1{[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r]([m5C])}$$$$V2.0
526 RNA1{[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r]([m5C])}$$$$V2.0
527 RNA1{[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r]([m5C])}$$$$V2.0
528 RNA1{[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r]([m5C])}$$$$V2.0
529 RNA1{[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[moe](T)[sp].[moe](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r]([m5C])}$$$$V2.0
530 RNA1{[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r]([m5C])}$$$$V2.0
531 RNA1{[moe](T)[sp].[fl2r](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[moe]([m5C])[sp].[fl2r](T)[sp].[moe](T)[sp].[fl2r](G)[sp].[moe](T)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[fl2r](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[moe](A)[sp].[fl2r](T)[sp].[moe]([m5C])[sp].[fl2r]([m5C])}$$$$V2.0
532 RNA1{[fl2r](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[moe](T)[sp].[fl2r](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[moe](A)[sp].[fl2r]([m5C])[sp].[moe](T)[sp].[fl2r](T)[sp].[moe]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[moe]([m5C])}$$$$V2.0
533 RNA1{[fl2r](T)[sp].[fl2r](G)[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[moe](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r]([m5C])}$$$$V2.0
534 RNA1{[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
535 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
536 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
537 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
538 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
539 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
540 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
541 RNA1{[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](G)[sp].[moe]([m5C])}$$$$V2.0
542 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](G)}$$$$V2.0
543 RNA1{[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)}$$$$V2.0
544 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)}$$$$V2.0
545 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])}$$$$V2.0
546 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
547 RNA1{[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)}$$$$V2.0
548 RNA1{[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)}$$$$V2.0
549 RNA1{[moe](G)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)}$$$$V2.0
550 RNA1{[moe](G)[sp].[moe](G)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe]([m5C])}$$$$V2.0
551 RNA1{[moe](G)[sp].[moe](G)[sp].[moe](G)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)}$$$$V2.0
552 RNA1{[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](G)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](G)}$$$$V2.0
553 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
554 RNA1{[moe](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
555 RNA1{[moe](T)[sp].[moe](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
556 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
557 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
558 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
559 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
560 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
561 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[lna](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
562 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[lna](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
563 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
564 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
565 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
566 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
567 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
568 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
569 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[moe]([m5C])}$$$$V2.0
570 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
571 RNA1{[lna](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)}$$$$V2.0
572 RNA1{[moe](A)[sp].[lna](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)}$$$$V2.0
573 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
574 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
575 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)}$$$$V2.0
576 RNA1{[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
577 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
578 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
579 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)}$$$$V2.0
580 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)}$$$$V2.0
581 RNA1{[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])}$$$$V2.0
582 RNA1{[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)}$$$$V2.0
583 RNA1{[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
584 RNA1{[lna](T)[sp].[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
585 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
586 RNA1{[lna](T)[sp].[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
587 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
588 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[lna]([m5C])[sp].[lna](T)[sp].[lna](T)}$$$$V2.0
589 RNA1{[lna](A)[sp].[lna](G)[sp].[lna](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[lna](T)[sp].[lna](A)[sp].[lna]([m5C])}$$$$V2.0
590 RNA1{[lna](A)[sp].[lna](A)[sp].[lna](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna](G)[sp].[lna](T)[sp].[lna](A)}$$$$V2.0
591 RNA1{[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)}$$$$V2.0
592 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
593 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
594 RNA1{[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
595 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
596 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)}$$$$V2.0
597 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
598 RNA1{[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)}$$$$V2.0
599 RNA1{[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)}$$$$V2.0
600 RNA1{[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])}$$$$V2.0
601 RNA1{[lna](T)[sp].[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
602 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
603 RNA1{[lna](T)[sp].[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
604 RNA1{[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
605 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
606 RNA1{[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
607 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
608 RNA1{[lna](G)[sp].[lna](G)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[lna]([m5C])[sp].[lna](T)[sp].[lna](T)}$$$$V2.0
609 RNA1{[lna](A)[sp].[lna](G)[sp].[lna](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[lna](A)[sp].[lna]([m5C])[sp].[lna](T)}$$$$V2.0
610 RNA1{[lna](A)[sp].[lna](A)[sp].[lna](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[lna](T)[sp].[lna](A)[sp].[lna]([m5C])}$$$$V2.0
611 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)}$$$$V2.0
612 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
613 RNA1{[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
614 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
615 RNA1{[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)}$$$$V2.0
616 RNA1{[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)}$$$$V2.0
617 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
618 RNA1{[lna](T)[sp].[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
619 RNA1{[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
620 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
621 RNA1{[lna](A)[sp].[lna](G)[sp].[lna](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[lna]([m5C])[sp].[lna](T)[sp].[lna](T)}$$$$V2.0
622 RNA1{[lna](A)[sp].[lna](A)[sp].[lna](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[lna](A)[sp].[lna]([m5C])[sp].[lna](T)}$$$$V2.0
623 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)}$$$$V2.0
624 RNA1{[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
625 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
626 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
627 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
628 RNA1{[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)}$$$$V2.0
629 RNA1{[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
630 RNA1{[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)}$$$$V2.0
631 RNA1{[lna](T)[sp].[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
632 RNA1{[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
633 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
634 RNA1{[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
635 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
636 RNA1{[lna](G)[sp].[lna](G)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
637 RNA1{[lna](A)[sp].[lna](G)[sp].[lna](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
638 RNA1{[lna](A)[sp].[lna](A)[sp].[lna](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[lna]([m5C])[sp].[lna](T)[sp].[lna](T)}$$$$V2.0
639 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)}$$$$V2.0
640 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
641 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
642 RNA1{[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
643 RNA1{[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
644 RNA1{[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)}$$$$V2.0
645 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
646 RNA1{[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
647 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
648 RNA1{[lna](G)[sp].[lna](G)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
649 RNA1{[lna](A)[sp].[lna](G)[sp].[lna](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
650 RNA1{[lna](A)[sp].[lna](A)[sp].[lna](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
651 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)}$$$$V2.0
652 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
653 RNA1{[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
654 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
655 RNA1{[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
656 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](G)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
657 RNA1{[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
658 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
659 RNA1{[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)}$$$$V2.0
660 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
661 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
662 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
663 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
664 RNA1{[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
665 RNA1{[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
666 RNA1{[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
667 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
668 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
669 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
670 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)}$$$$V2.0
671 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
672 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)}$$$$V2.0
673 RNA1{[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)}$$$$V2.0
674 RNA1{[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
675 RNA1{[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)}$$$$V2.0
676 RNA1{[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)}$$$$V2.0
677 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].m(U)[sp].m(G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].m(C)[sp].m(A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
678 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].m(U)[sp].m(G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].m(A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
679 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
680 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
681 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
682 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
683 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
684 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[lna](A)[sp].[lna]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
685 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
686 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].m(U)[sp].m(G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].m(C)[sp].m(A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
687 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].m(U)[sp].m(G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].m(A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
688 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
689 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
690 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
691 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
692 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
693 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[lna](A)[sp].[lna]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
694 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
695 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(A)[sp].[moe]([m5C])[sp].m(U)[sp].m(U)[sp].[moe]([m5C])[sp].m(A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
696 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(A)[sp].[moe]([m5C])[sp].m(U)[sp].m(U)[sp].[moe]([m5C])[sp].m(A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
697 RNA1{[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
698 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
699 RNA1{[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
700 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
701 RNA1{[moe](G)[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
702 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
703 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna](G)[sp].[lna](T)[sp].[moe](A)[sp].[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
704 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[moe](G)[sp].[lna](T)[sp].[lna](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
705 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
706 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
707 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[lna](T)[sp].[lna](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
708 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[lna](T)[sp].[lna](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
709 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
710 RNA1{[moe](G)[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
711 RNA1{[lna](G)[sp].[moe](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[moe]([m5C])}$$$$V2.0
712 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
713 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[moe](A)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
714 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[lna](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
715 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[lna](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
716 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[lna](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
717 RNA1{[moe](G)[sp].[moe](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[moe]([m5C])}$$$$V2.0
718 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)}$$$$V2.0
719 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
720 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)}$$$$V2.0
721 RNA1{[moe](T)[sp].[lna](G)[sp].[moe](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
722 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
723 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[lna](T)[sp].[moe](A)[sp].[lna]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
724 RNA1{[moe](T)[sp].[moe](G)[sp].[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)}$$$$V2.0
725 RNA1{[lna](T)[sp].[moe](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[lna](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
726 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna](G)[sp].[moe](T)[sp].[lna](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
727 RNA1{[moe](T)[sp].[moe](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
728 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](A)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
729 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[lna](A)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
730 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[lna](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
731 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[lna](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
732 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](A)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
733 RNA1{[moe](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[lna](T)[sp].[lna](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)}$$$$V2.0
734 RNA1{[moe](T)[sp].[lna](G)[sp].[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
735 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[lna](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
736 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna](G)[sp].[lna](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
737 RNA1{[moe](T)[sp].[moe](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[lna](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
738 RNA1{[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
739 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
740 RNA1{[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
741 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
742 RNA1{[moe]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[lna](A)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
743 RNA1{[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[lna](T)[sp].[lna](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
744 RNA1{[moe]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
745 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna](G)[sp].[moe](T)[sp].[lna](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
746 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
747 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
748 RNA1{[moe]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](A)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
749 RNA1{[lna]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[lna](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
750 RNA1{[lna]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[moe](A)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
751 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
752 RNA1{[lna]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[lna](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
753 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[moe](G)[sp].[lna](T)[sp].[moe](A)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
754 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[moe](G)[sp].[lna](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
755 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
756 RNA1{[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna](G)[sp].[lna](T)[sp].[lna](A)[sp].[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
757 RNA1{[lna]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[lna](A)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
758 RNA1{[moe]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[lna](A)[sp].[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
759 RNA1{[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)}$$$$V2.0
760 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
761 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)}$$$$V2.0
762 RNA1{[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
763 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)}$$$$V2.0
764 RNA1{[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
765 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
766 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
767 RNA1{[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[lna](T)[sp].[lna](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)}$$$$V2.0
768 RNA1{[moe](G)[sp].[lna](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[lna](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)}$$$$V2.0
769 RNA1{[moe](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
770 RNA1{[moe](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
771 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[lna](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)}$$$$V2.0
772 RNA1{[moe](G)[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[moe](A)[sp].[lna](T)}$$$$V2.0
773 RNA1{[moe](G)[sp].[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[lna](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
774 RNA1{[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna](G)[sp].[moe](T)[sp].[lna](A)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[moe](T)}$$$$V2.0
775 RNA1{[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
776 RNA1{[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[lna](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[moe](A)[sp].[lna](T)}$$$$V2.0
777 RNA1{[moe](G)[sp].[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna](G)[sp].[lna](T)[sp].[lna](A)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
778 RNA1{[moe](G)[sp].[moe](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[lna](T)[sp].[lna](A)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[moe](A)[sp].[lna](T)}$$$$V2.0
779 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe](G)[sp].[lna](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[moe](T)}$$$$V2.0
780 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)}$$$$V2.0
781 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)}$$$$V2.0
782 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
783 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
784 RNA1{[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)}$$$$V2.0
785 RNA1{[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)}$$$$V2.0
786 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)}$$$$V2.0
787 RNA1{[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)}$$$$V2.0
788 RNA1{[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)}$$$$V2.0
789 RNA1{[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)}$$$$V2.0
790 RNA1{[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)}$$$$V2.0
791 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
792 RNA1{[lna](T)[sp].[lna]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[lna](T)[sp].[lna](T)}$$$$V2.0
793 RNA1{[lna](T)[sp].[lna]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](T)}$$$$V2.0
794 RNA1{[lna](T)[sp].[lna]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
795 RNA1{[lna](T)[sp].[lna]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
796 RNA1{[lna]([m5C])[sp].[lna]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](G)[sp].[lna](A)}$$$$V2.0
797 RNA1{[lna](A)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](G)[sp].[lna](A)}$$$$V2.0
798 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](G)[sp].[lna](A)}$$$$V2.0
799 RNA1{[lna](T)[sp].[lna](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](G)[sp].[lna](A)}$$$$V2.0
800 RNA1{[lna](A)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](T)}$$$$V2.0
801 RNA1{[lna]([m5C])[sp].[lna](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](G)}$$$$V2.0
802 RNA1{[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[lna](A)[sp].[lna](A)}$$$$V2.0
803 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
804 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)[sp].[moe](A)}$$$$V2.0
805 RNA1{[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](A)[sp].[moe](A)}$$$$V2.0
806 RNA1{[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](A)}$$$$V2.0
807 RNA1{[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
808 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe](A)}$$$$V2.0
809 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
810 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)}$$$$V2.0
811 RNA1{[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)}$$$$V2.0
812 RNA1{[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)}$$$$V2.0
813 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)}$$$$V2.0
814 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
815 RNA1{[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)}$$$$V2.0
816 RNA1{[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)}$$$$V2.0
817 RNA1{[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
818 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)}$$$$V2.0
819 RNA1{[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
820 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)}$$$$V2.0
821 RNA1{[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)}$$$$V2.0
822 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)}$$$$V2.0
823 RNA1{[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
824 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
825 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)}$$$$V2.0
826 RNA1{[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)}$$$$V2.0
827 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)}$$$$V2.0
828 RNA1{[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)}$$$$V2.0
829 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
830 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
831 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
832 RNA1{[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)}$$$$V2.0
833 RNA1{[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
834 RNA1{[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)}$$$$V2.0
835 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)}$$$$V2.0
836 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)}$$$$V2.0
837 RNA1{[lna](T)[sp].[lna](C)[sp].m(A)[sp].m(U)[sp].m(C)[sp].m(C)[sp].m(C)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(G)[sp].m(A)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].[lna](G)[sp].[lna](A)}$$$$V2.0
838 RNA1{m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(U)[sp].m(C)[sp].m(C)[sp].m(C)[sp].m(A)}$$$$V2.0
839 RNA1{m(G)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(U)[sp].m(C)[sp].m(C)[sp].m(C)}$$$$V2.0
840 RNA1{m(U)[sp].m(G)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(U)[sp].m(C)[sp].m(C)}$$$$V2.0
841 RNA1{[lna](T)[sp].[lna](G)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(U)[sp].[lna](C)[sp].[lna](C)}$$$$V2.0
842 RNA1{m(G)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(U)[sp].m(C)}$$$$V2.0
843 RNA1{[lna](G)[sp].[lna](T)[sp].m(G)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].[lna](T)[sp].[lna](C)}$$$$V2.0
844 RNA1{m(G)[sp].m(G)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(U)}$$$$V2.0
845 RNA1{m(A)[sp].m(G)[sp].m(G)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)}$$$$V2.0
846 RNA1{m(A)[sp].m(G)[sp].m(C)[sp].m(C)[sp].m(A)[sp].m(U)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(U)[sp].m(G)[sp].m(A)[sp].m(A)[sp].m(U)[sp].m(C)[sp].m(C)}$$$$V2.0
847 RNA1{[lna](T)[sp].[lna](G)[sp].m(T)[sp].m(T)[sp].m([m5C])[sp].m(T)[sp].m(T)[sp].m(G)[sp].m(T)[sp].m(A)[sp].m([m5C])[sp].m(T)[sp].m(T)[sp].m([m5C])[sp].m(A)[sp].m(T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
848 RNA1{[lna](G)[sp].[lna](T)[sp].m(G)[sp].m(T)[sp].m(T)[sp].m([m5C])[sp].m(T)[sp].m(T)[sp].m(G)[sp].m(T)[sp].m(A)[sp].m([m5C])[sp].m(T)[sp].m(T)[sp].m([m5C])[sp].m(A)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
849 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](U)[sp].[fl2r](C)[sp].[fl2r](U)[sp].[fl2r](U)[sp].[fl2r](G)[sp].[fl2r](U)[sp].[fl2r](A)[sp].[fl2r](C)[sp].[fl2r](U)[sp].[fl2r](U)[sp].[fl2r](C)[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
850 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)}$$$$V2.0
851 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
852 RNA1{[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
853 RNA1{[lna](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)}$$$$V2.0
854 RNA1{[moe](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[moe](T)[sp].[moe](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
855 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
856 RNA1{[lna](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[lna]([m5C])}$$$$V2.0
857 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
858 RNA1{[lna](A)[sp].[lna](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
859 RNA1{[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[lna]([m5C])}$$$$V2.0
860 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
861 RNA1{[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
862 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
863 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
864 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
865 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
866 RNA1{[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
867 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
868 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
869 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
870 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
871 RNA1{[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
872 RNA1{[lna](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
873 RNA1{[lna](T)[sp].[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
874 RNA1{[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
875 RNA1{[lna](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
876 RNA1{[lna](T)[sp].[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
877 RNA1{[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
878 RNA1{[lna](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
879 RNA1{[lna](T)[sp].[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
880 RNA1{[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
881 RNA1{[lna](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
882 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
883 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
884 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
885 RNA1{[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
886 RNA1{[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
887 RNA1{[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
888 RNA1{[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
889 RNA1{[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
890 RNA1{[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
891 RNA1{[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
892 RNA1{[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
893 RNA1{[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
894 RNA1{[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
895 RNA1{[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
896 RNA1{[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
897 RNA1{[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
898 RNA1{[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
899 RNA1{[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
900 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
901 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
902 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)}$$$$V2.0
903 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
904 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
905 RNA1{[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)}$$$$V2.0
906 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)}$$$$V2.0
907 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe](A)}$$$$V2.0
908 RNA1{[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[lna](A)}$$$$V2.0
909 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[lna](A)}$$$$V2.0
910 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[lna](A)}$$$$V2.0
911 RNA1{[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
912 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
913 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
914 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
915 RNA1{[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
916 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
917 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
918 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
919 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
920 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
921 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
922 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[lna](A)}$$$$V2.0
923 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
924 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
925 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)}$$$$V2.0
926 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)}$$$$V2.0
927 RNA1{[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)}$$$$V2.0
928 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)}$$$$V2.0
929 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)}$$$$V2.0
930 RNA1{[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)}$$$$V2.0
931 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
932 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
933 RNA1{[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
934 RNA1{[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
935 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
936 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
937 RNA1{[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
938 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
939 RNA1{[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
940 RNA1{[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
941 RNA1{[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[lna]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
942 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
943 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
944 RNA1{[lna](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
945 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
946 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
947 RNA1{[lna](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
948 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
949 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
950 RNA1{[lna](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
951 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
952 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
953 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
954 RNA1{[lna](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
955 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
956 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
957 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[lna]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
958 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[lna]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
959 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[lna]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
960 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[lna](A)[sp].[lna]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
961 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
962 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
963 RNA1{[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
964 RNA1{[lna](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
965 RNA1{[lna](T)[sp].[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
966 RNA1{[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
967 RNA1{[lna](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
968 RNA1{[lna](T)[sp].[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
969 RNA1{[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
970 RNA1{[lna](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
971 RNA1{[lna](T)[sp].[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
972 RNA1{[lna](T)[sp].[lna]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
973 RNA1{[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
974 RNA1{[lna](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
975 RNA1{[lna](T)[sp].[lna]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
976 RNA1{[lna](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
977 RNA1{[lna](T)[sp].[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
978 RNA1{[lna](T)[sp].[lna]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
979 RNA1{[lna](T)[sp].[lna]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
980 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
981 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
982 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
983 RNA1{[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
984 RNA1{[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
985 RNA1{[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
986 RNA1{[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
987 RNA1{[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
988 RNA1{[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
989 RNA1{[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
990 RNA1{[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
991 RNA1{[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
992 RNA1{[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
993 RNA1{[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
994 RNA1{[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
995 RNA1{[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
996 RNA1{[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
997 RNA1{[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
998 RNA1{[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
999 RNA1{[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1000 RNA1{[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1001 RNA1{[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1002 RNA1{[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1003 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
1004 RNA1{[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
1005 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
1006 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
1007 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
1008 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
1009 RNA1{[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
1010 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
1011 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
1012 RNA1{[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
1013 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
1014 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
1015 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
1016 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
1017 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
1018 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
1019 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
1020 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
1021 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
1022 RNA1{[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
1023 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
1024 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
1025 RNA1{[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
1026 RNA1{[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)}$$$$V2.0
1027 RNA1{[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
1028 RNA1{[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
1029 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
1030 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
1031 RNA1{[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
1032 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
1033 RNA1{[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
1034 RNA1{[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
1035 RNA1{[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
1036 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)}$$$$V2.0
1037 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
1038 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
1039 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
1040 RNA1{[lna](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)}$$$$V2.0
1041 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)}$$$$V2.0
1042 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)}$$$$V2.0
1043 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)}$$$$V2.0
1044 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)}$$$$V2.0
1045 RNA1{[lna](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
1046 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
1047 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
1048 RNA1{[lna](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
1049 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
1050 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
1051 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
1052 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
1053 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
1054 RNA1{[lna](G)[sp].[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[lna]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
1055 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)}$$$$V2.0
1056 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
1057 RNA1{[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](A)}$$$$V2.0
1058 RNA1{[lna](G)[sp].[lna](G)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
1059 RNA1{[lna](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
1060 RNA1{[lna](G)[sp].[lna](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
1061 RNA1{[lna](G)[sp].[lna](G)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
1062 RNA1{[lna](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
1063 RNA1{[lna](G)[sp].[lna](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
1064 RNA1{[lna](G)[sp].[lna](G)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
1065 RNA1{[lna](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
1066 RNA1{[lna](G)[sp].[lna](G)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
1067 RNA1{[lna](G)[sp].[lna](G)[sp].[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
1068 RNA1{[lna](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
1069 RNA1{[lna](G)[sp].[lna](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
1070 RNA1{[lna](G)[sp].[lna](G)[sp].[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
1071 RNA1{[lna](G)[sp].[lna](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[lna]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
1072 RNA1{[lna](G)[sp].[lna](G)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[lna]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
1073 RNA1{[lna](G)[sp].[lna](G)[sp].[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[lna]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
1074 RNA1{[lna](G)[sp].[lna](G)[sp].[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[lna](A)[sp].[lna]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
1075 RNA1{[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
1076 RNA1{[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
1077 RNA1{[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])}$$$$V2.0
1078 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[moe](A)[sp].[lna](T)}$$$$V2.0
1079 RNA1{[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[moe](A)[sp].[lna](T)}$$$$V2.0
1080 RNA1{[moe](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[moe](A)[sp].[lna](T)}$$$$V2.0
1081 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[moe](T)}$$$$V2.0
1082 RNA1{[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[moe](T)}$$$$V2.0
1083 RNA1{[moe](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[moe](T)}$$$$V2.0
1084 RNA1{[moe](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
1085 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
1086 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
1087 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
1088 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
1089 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[lna](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
1090 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[lna](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
1091 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
1092 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
1093 RNA1{[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
1094 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[moe](T)}$$$$V2.0
1095 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[moe](T)}$$$$V2.0
1096 RNA1{[lna](T)[sp].[moe](G)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
1097 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
1098 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
1099 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
1100 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
1101 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
1102 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[lna](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
1103 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[lna](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
1104 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
1105 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
1106 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)}$$$$V2.0
1107 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](A)[sp].[lna](G)}$$$$V2.0
1108 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)}$$$$V2.0
1109 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])}$$$$V2.0
1110 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)}$$$$V2.0
1111 RNA1{[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
1112 RNA1{[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe](A)}$$$$V2.0
1113 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)}$$$$V2.0
1114 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)}$$$$V2.0
1115 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
1116 RNA1{[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe](A)}$$$$V2.0
1117 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe](A)}$$$$V2.0
1118 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
1119 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe](A)}$$$$V2.0
1120 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)}$$$$V2.0
1121 RNA1{[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
1122 RNA1{[lna](T)[sp].[moe](G)[sp].m(T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1123 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].m(T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1124 RNA1{[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[moe](T)[sp].m([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1125 RNA1{[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].m(T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna](A)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1126 RNA1{[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].m(T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1127 RNA1{[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](T)[sp].[moe](T)[sp].m(G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1128 RNA1{[lna](T)[sp].m(G)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(U)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1129 RNA1{[lna](T)[sp].[lna](G)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(U)[sp].m(C)[sp].[lna]([m5C])}$$$$V2.0
1130 RNA1{[lna](T)[sp].m(G)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(U)[sp].m(C)[sp].[lna]([m5C])}$$$$V2.0
1131 RNA1{[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1132 RNA1{[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(U)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1133 RNA1{[lna](T)[sp].[lna](G)[sp].m(U)[sp].[lna](T)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(U)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1134 RNA1{[lna](T)[sp].[lna](G)[sp].m(U)[sp].m(U)[sp].[lna]([m5C])[sp].m(U)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(U)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1135 RNA1{[lna](T)[sp].[lna](G)[sp].m(U)[sp].m(U)[sp].m(C)[sp].[lna](T)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(U)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1136 RNA1{[lna](T)[sp].[lna](G)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].[lna](T)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(U)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1137 RNA1{[lna](T)[sp].[lna](G)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].[lna](G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(U)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1138 RNA1{[lna](T)[sp].[lna](G)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(G)[sp].[lna](T)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(U)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1139 RNA1{[lna](T)[sp].[lna](G)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(G)[sp].m(U)[sp].[lna](A)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(U)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1140 RNA1{[lna](T)[sp].[lna](G)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(A)[sp].[lna]([m5C])[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(U)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1141 RNA1{[lna](T)[sp].[lna](G)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].[lna](T)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(U)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1142 RNA1{[lna](T)[sp].[lna](G)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].m(U)[sp].[lna](T)[sp].m(C)[sp].m(A)[sp].m(U)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1143 RNA1{[lna](T)[sp].[lna](G)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(U)[sp].[lna]([m5C])[sp].m(A)[sp].m(U)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1144 RNA1{[lna](T)[sp].[lna](G)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(C)[sp].[lna](A)[sp].m(U)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1145 RNA1{[lna](T)[sp].[lna](G)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1146 RNA1{[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[lna](T)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(C)[sp].[lna](A)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1147 RNA1{[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].m(U)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(U)[sp].[lna]([m5C])[sp].[lna](A)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1148 RNA1{[moe](T)[sp].m(G)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(U)[sp].m(C)[sp].[moe]([m5C])}$$$$V2.0
1149 RNA1{[moe](T)[sp].[moe](G)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(U)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1150 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1151 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(C)[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1152 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].m(U)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(U)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1153 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].m(U)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].m(U)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1154 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1155 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].m(U)[sp].m(A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1156 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna](G)[sp].[lna](T)[sp].[lna](A)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1157 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna](G)[sp].[lna](T)[sp].[lna](A)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1158 RNA1{m(U)[sp].m(G)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].[lna](G)[sp].[lna](T)[sp].[lna](A)[sp].[lna]([m5C])[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(U)[sp].m(C)[sp].m(C)}$$$$V2.0
1159 RNA1{[lna](T)[sp].[lna](G)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(U)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1160 RNA1{[lna](T)[sp].[lna](G)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].[lna](G)[sp].[lna](T)[sp].[lna](A)[sp].[lna]([m5C])[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(U)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1161 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1162 RNA1{[moe](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])}$$$$V2.0
1163 RNA1{[lna](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
1164 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].m(G)[sp].m(U)[sp].m(A)[sp].m(C)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)}$$$$V2.0
1165 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1166 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1167 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[moe](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1168 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1169 RNA1{[moe](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1170 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1171 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1172 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1173 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1174 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1175 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1176 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1177 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1178 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[moe](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1179 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1180 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1181 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1182 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1183 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1184 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1185 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1186 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1187 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1188 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[moe](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1189 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[moe](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1190 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1191 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1192 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1193 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1194 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1195 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1196 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1197 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1198 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1199 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[moe](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1200 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1201 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1202 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1203 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1204 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1205 RNA1{[lna](T)[sp].[lna](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1206 RNA1{[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1207 RNA1{[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[lna](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[lna](A)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1208 RNA1{[lna](T)[sp].[lna](G)[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[lna](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1209 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1210 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1211 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1212 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1213 RNA1{[lna](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
1214 RNA1{[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[lna](G)}$$$$V2.0
1215 RNA1{[lna](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[lna](G)}$$$$V2.0
1216 RNA1{[lna](A)[sp].[lna](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[lna](G)}$$$$V2.0
1217 RNA1{[lna](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](A)[sp].[lna](G)}$$$$V2.0
1218 RNA1{[lna](A)[sp].[lna](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](A)[sp].[lna](G)}$$$$V2.0
1219 RNA1{[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](A)[sp].[lna](G)}$$$$V2.0
1220 RNA1{[lna](T)[sp].m(C)[sp].m(U)[sp].m(G)[sp].m(A)[sp].m(A)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(U)[sp].[lna]([m5C])[sp].m(A)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(A)[sp].m(G)[sp].[lna](A)}$$$$V2.0
1221 RNA1{[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])}$$$$V2.0
1222 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)}$$$$V2.0
1223 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)}$$$$V2.0
1224 RNA1{[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
1225 RNA1{[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[moe](A)}$$$$V2.0
1226 RNA1{[lna]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)}$$$$V2.0
1227 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](A)}$$$$V2.0
1228 RNA1{[lna](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[lna](G)}$$$$V2.0
1229 RNA1{[lna](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)[sp].[lna](A)}$$$$V2.0
1230 RNA1{m(C)[sp].m(U)[sp].m(G)[sp].m(A)[sp].m(A)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(A)[sp].m(G)}$$$$V2.0
1231 RNA1{[lna]([m5C])[sp].m(U)[sp].m(G)[sp].m(A)[sp].m(A)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(A)[sp].m(G)}$$$$V2.0
1232 RNA1{m(C)[sp].m(U)[sp].m(G)[sp].m(A)[sp].m(A)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(A)[sp].[lna](G)}$$$$V2.0
1233 RNA1{[lna]([m5C])[sp].m(U)[sp].m(G)[sp].m(A)[sp].m(A)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(A)[sp].[lna](G)}$$$$V2.0
1234 RNA1{[lna]([m5C])[sp].[lna](T)[sp].m(G)[sp].m(A)[sp].m(A)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(A)[sp].m(C)[sp].m(U)[sp].[lna](A)[sp].[lna](G)}$$$$V2.0
1235 RNA1{m(U)[sp].m(C)[sp].m(U)[sp].m(G)[sp].m(A)[sp].m(A)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(A)[sp].m(G)[sp].m(A)}$$$$V2.0
1236 RNA1{[lna](T)[sp].m(C)[sp].m(U)[sp].m(G)[sp].m(A)[sp].m(A)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(A)[sp].m(G)[sp].m(A)}$$$$V2.0
1237 RNA1{m(U)[sp].m(C)[sp].m(U)[sp].m(G)[sp].m(A)[sp].m(A)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(A)[sp].m(G)[sp].[lna](A)}$$$$V2.0
1238 RNA1{[lna](T)[sp].m(C)[sp].m(U)[sp].m(G)[sp].m(A)[sp].m(A)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(A)[sp].m(G)[sp].[lna](A)}$$$$V2.0
1239 RNA1{[lna](T)[sp].[lna]([m5C])[sp].m(U)[sp].m(G)[sp].m(A)[sp].m(A)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(A)[sp].[lna](G)[sp].[lna](A)}$$$$V2.0
1240 RNA1{[moe]([m5C])[sp].m(U)[sp].m(G)[sp].m(A)[sp].m(A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
1241 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
1242 RNA1{[moe]([m5C])[sp].m(U)[sp].m(G)[sp].m(A)[sp].m(A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
1243 RNA1{[moe]([m5C])[sp].m(U)[sp].m(G)[sp].m(A)[sp].m(A)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
1244 RNA1{[lna]([m5C])[sp].m(U)[sp].m(G)[sp].m(A)[sp].m(A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[lna](G)}$$$$V2.0
1245 RNA1{[lna]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[lna](G)}$$$$V2.0
1246 RNA1{[lna]([m5C])[sp].m(U)[sp].m(G)[sp].m(A)[sp].m(A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[lna](G)}$$$$V2.0
1247 RNA1{[lna]([m5C])[sp].m(U)[sp].m(G)[sp].m(A)[sp].m(A)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[lna](G)}$$$$V2.0
1248 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[lna](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
1249 RNA1{[moe]([m5C])[sp].[lna](T)[sp].[lna](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
1250 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
1251 RNA1{[moe]([m5C])[sp].[lna](T)[sp].[lna](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
1252 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[lna](A)[sp].[lna](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
1253 RNA1{[moe]([m5C])[sp].[moe](T)[sp].m(G)[sp].m(A)[sp].m(A)[sp].m(U)[sp].m(U)[sp].m(C)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
1254 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[lna](G)[sp].[lna](A)[sp].[lna](A)[sp].[lna](T)[sp].[lna](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
1255 RNA1{[lna]([m5C])[sp].[moe](T)[sp].m(G)[sp].m(A)[sp].m(A)[sp].m(U)[sp].m(U)[sp].m(C)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[lna](G)}$$$$V2.0
1256 RNA1{[lna]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[lna](G)}$$$$V2.0
1257 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[lna](G)[sp].m(A)[sp].m(A)[sp].m(U)[sp].m(U)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
1258 RNA1{[lna]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[lna](A)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[lna](G)}$$$$V2.0
1259 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[lna](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
1260 RNA1{[lna]([m5C])[sp].[moe](T)[sp].m(G)[sp].m(A)[sp].[moe](A)[sp].[moe](T)[sp].m(U)[sp].m(C)[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[lna](G)}$$$$V2.0
1261 RNA1{[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].m(C)[sp].m(U)[sp].m(A)[sp].m(G)}$$$$V2.0
1262 RNA1{[lna](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].m(C)[sp].m(U)[sp].m(A)[sp].[lna](G)}$$$$V2.0
1263 RNA1{[lna](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].m(C)[sp].m(U)[sp].[moe](A)[sp].[lna](G)}$$$$V2.0
1264 RNA1{[lna](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].m(C)[sp].m(U)[sp].[lna](A)[sp].[lna](G)}$$$$V2.0
1265 RNA1{[lna](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].m(C)[sp].[moe](T)[sp].[moe](A)[sp].[lna](G)}$$$$V2.0
1266 RNA1{[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[lna]([m5C])[sp].[lna](T)[sp].[lna](A)[sp].[lna](G)}$$$$V2.0
1267 RNA1{[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[lna]([m5C])[sp].[lna](T)[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
1268 RNA1{[lna](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[lna]([m5C])[sp].[lna](T)[sp].[moe](A)[sp].[lna](G)}$$$$V2.0
1269 RNA1{[lna](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[lna]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[lna](G)}$$$$V2.0
1270 RNA1{[moe](A)[sp].m(A)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(A)[sp].[moe](G)}$$$$V2.0
1271 RNA1{[lna](A)[sp].m(A)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(A)[sp].[lna](G)}$$$$V2.0
1272 RNA1{[lna](A)[sp].[lna](A)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(A)[sp].m(C)[sp].m(U)[sp].[lna](A)[sp].[lna](G)}$$$$V2.0
1273 RNA1{[lna](A)[sp].[lna](A)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(A)[sp].m(C)[sp].m(U)[sp].m(A)[sp].[lna](G)}$$$$V2.0
1274 RNA1{[lna](A)[sp].m(A)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(A)[sp].m(C)[sp].m(U)[sp].[lna](A)[sp].[lna](G)}$$$$V2.0
1275 RNA1{[lna](A)[sp].[lna](A)[sp].[lna](T)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(A)[sp].m(C)[sp].m(U)[sp].[lna](A)[sp].[lna](G)}$$$$V2.0
1276 RNA1{[lna](A)[sp].[lna](A)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(A)[sp].m(C)[sp].[lna](T)[sp].[lna](A)[sp].[lna](G)}$$$$V2.0
1277 RNA1{[lna](A)[sp].m(A)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(U)[sp].m(U)[sp].m(U)[sp].[lna]([m5C])[sp].m(A)[sp].m(A)[sp].m(C)[sp].m(U)[sp].[lna](A)[sp].[lna](G)}$$$$V2.0
1278 RNA1{[lna](A)[sp].m(A)[sp].m(U)[sp].m(U)[sp].[lna]([m5C])[sp].m(U)[sp].m(U)[sp].m(U)[sp].m(C)[sp].m(A)[sp].m(A)[sp].m(C)[sp].m(U)[sp].[lna](A)[sp].[lna](G)}$$$$V2.0
1279 RNA1{[fl2r](C)[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[fl2r](G)}$$$$V2.0
1280 RNA1{[fl2r](C)[sp].[fl2r](U)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[fl2r](A)[sp].[fl2r](G)}$$$$V2.0
1281 RNA1{[fl2r](C)[sp].[fl2r](U)[sp].[fl2r](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[fl2r](U)[sp].[fl2r](A)[sp].[fl2r](G)}$$$$V2.0
1282 RNA1{[fl2r](C)[sp].[fl2r](U)[sp].[fl2r](G)[sp].[fl2r](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[fl2r](C)[sp].[fl2r](U)[sp].[fl2r](A)[sp].[fl2r](G)}$$$$V2.0
1283 RNA1{[fl2r](C)[sp].[fl2r](U)[sp].[fl2r](G)[sp].[fl2r](A)[sp].[fl2r](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[fl2r](A)[sp].[fl2r](C)[sp].[fl2r](U)[sp].[fl2r](A)[sp].[fl2r](G)}$$$$V2.0
1284 RNA1{[fl2r](C)[sp].[fl2r](U)[sp].[fl2r](G)[sp].[fl2r](A)[sp].[fl2r](A)[sp].[fl2r](U)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[fl2r](A)[sp].[fl2r](A)[sp].[fl2r](C)[sp].[fl2r](U)[sp].[fl2r](A)[sp].[fl2r](G)}$$$$V2.0
1285 RNA1{[fl2r](C)[sp].[fl2r](U)[sp].[fl2r](G)[sp].[fl2r](A)[sp].[fl2r](A)[sp].[fl2r](U)[sp].[fl2r](U)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[fl2r](C)[sp].[fl2r](A)[sp].[fl2r](A)[sp].[fl2r](C)[sp].[fl2r](U)[sp].[fl2r](A)[sp].[fl2r](G)}$$$$V2.0
1286 RNA1{[fl2r](C)[sp].[fl2r](U)[sp].[fl2r](G)[sp].[fl2r](A)[sp].[fl2r](A)[sp].[fl2r](U)[sp].[fl2r](U)[sp].[fl2r](C)[sp].[moe](T)[sp].[moe](T)[sp].[fl2r](U)[sp].[fl2r](C)[sp].[fl2r](A)[sp].[fl2r](A)[sp].[fl2r](C)[sp].[fl2r](U)[sp].[fl2r](A)[sp].[fl2r](G)}$$$$V2.0
1287 RNA1{[fl2r](C)[sp].[fl2r](U)[sp].[fl2r](G)[sp].[fl2r](A)[sp].[fl2r](A)[sp].[fl2r](U)[sp].[fl2r](U)[sp].[fl2r](C)[sp].[fl2r](U)[sp].[fl2r](U)[sp].[fl2r](U)[sp].[fl2r](C)[sp].[fl2r](A)[sp].[fl2r](A)[sp].[fl2r](C)[sp].[fl2r](U)[sp].[fl2r](A)[sp].[fl2r](G)}$$$$V2.0
1288 RNA1{[fl2r](C)[sp].[moe](T)[sp].[fl2r](G)[sp].[moe](A)[sp].[fl2r](A)[sp].[moe](T)[sp].[fl2r](U)[sp].[moe]([m5C])[sp].[fl2r](U)[sp].[moe](T)[sp].[fl2r](U)[sp].[moe]([m5C])[sp].[fl2r](A)[sp].[moe](A)[sp].[fl2r](C)[sp].[moe](T)[sp].[fl2r](A)[sp].[moe](G)}$$$$V2.0
1289 RNA1{[moe]([m5C])[sp].[fl2r](U)[sp].[moe](G)[sp].[fl2r](A)[sp].[moe](A)[sp].[fl2r](U)[sp].[moe](T)[sp].[fl2r](C)[sp].[moe](T)[sp].[fl2r](U)[sp].[moe](T)[sp].[fl2r](C)[sp].[moe](A)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[fl2r](U)[sp].[moe](A)[sp].[fl2r](G)}$$$$V2.0
1290 RNA1{[fl2r](C)[sp].[fl2r](U)[sp].[moe](G)[sp].[moe](A)[sp].[fl2r](A)[sp].[fl2r](U)[sp].[moe](T)[sp].[moe]([m5C])[sp].[fl2r](U)[sp].[fl2r](U)[sp].[moe](T)[sp].[moe]([m5C])[sp].[fl2r](A)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[fl2r](A)[sp].[fl2r](G)}$$$$V2.0
1291 RNA1{[fl2r](C)[sp].[fl2r](U)[sp].[fl2r](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[fl2r](U)[sp].[fl2r](C)[sp].[fl2r](U)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[fl2r](A)[sp].[fl2r](A)[sp].[fl2r](C)[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
1292 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[fl2r](U)[sp].[fl2r](U)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
1293 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[fl2r](C)[sp].[fl2r](U)[sp].[fl2r](U)[sp].[fl2r](U)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
1294 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[fl2r](U)[sp].[fl2r](C)[sp].[fl2r](U)[sp].[fl2r](U)[sp].[fl2r](U)[sp].[fl2r](C)[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
1295 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[fl2r](U)[sp].[fl2r](U)[sp].[fl2r](C)[sp].[fl2r](U)[sp].[fl2r](U)[sp].[fl2r](U)[sp].[fl2r](C)[sp].[fl2r](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
1296 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[fl2r](A)[sp].[fl2r](U)[sp].[fl2r](U)[sp].[fl2r](C)[sp].[fl2r](U)[sp].[fl2r](U)[sp].[fl2r](U)[sp].[fl2r](C)[sp].[fl2r](A)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
1297 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[fl2r](A)[sp].[fl2r](A)[sp].[fl2r](U)[sp].[fl2r](U)[sp].[fl2r](C)[sp].[fl2r](U)[sp].[fl2r](U)[sp].[fl2r](U)[sp].[fl2r](C)[sp].[fl2r](A)[sp].[fl2r](A)[sp].[fl2r](C)[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
1298 RNA1{[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)}$$$$V2.0
1299 RNA1{[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[lna]([m5C])[sp].[lna](T)}$$$$V2.0
1300 RNA1{[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)}$$$$V2.0
1301 RNA1{[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)}$$$$V2.0
1302 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)}$$$$V2.0
1303 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)}$$$$V2.0
1304 RNA1{[lna](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[lna]([m5C])}$$$$V2.0
1305 RNA1{[lna](A)[sp].[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[lna](A)[sp].[lna]([m5C])}$$$$V2.0
1306 RNA1{[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])}$$$$V2.0
1307 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])}$$$$V2.0
1308 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])}$$$$V2.0
1309 RNA1{[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])}$$$$V2.0
1310 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1311 RNA1{[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[moe](T)[sp].[moe](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1312 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[moe](T)[sp].[moe](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1313 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[moe](T)[sp].[moe](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1314 RNA1{[lna](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[moe](T)[sp].[moe](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1315 RNA1{[lna](T)[sp].[lna](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[moe](T)[sp].[moe](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1316 RNA1{[lna](T)[sp].[lna](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[lna]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1317 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[moe](T)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1318 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[moe](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1319 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1320 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1321 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1322 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1323 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1324 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1325 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1326 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1327 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1328 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1329 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1330 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1331 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1332 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1333 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1334 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1335 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1336 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1337 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1338 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1339 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1340 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1341 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1342 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1343 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1344 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1345 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1346 RNA1{[moe](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1347 RNA1{[lna](T)[sp].[fl2r](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1348 RNA1{[lna](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1349 RNA1{[lna](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[moe]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1350 RNA1{[lna](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1351 RNA1{[lna](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[moe](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1352 RNA1{[lna](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1353 RNA1{[lna](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[moe](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1354 RNA1{[lna](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[moe](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1355 RNA1{[lna](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1356 RNA1{[lna](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1357 RNA1{[lna](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1358 RNA1{[lna](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[moe]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1359 RNA1{[lna](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[moe](A)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1360 RNA1{[lna](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1361 RNA1{[lna](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1362 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1363 RNA1{[lna](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1364 RNA1{[lna](G)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[lna]([m5C])}$$$$V2.0
1365 RNA1{[lna](G)[sp].[moe](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
1366 RNA1{[lna](G)[sp].[moe](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
1367 RNA1{[lna](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
1368 RNA1{[lna](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
1369 RNA1{[lna](G)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[lna]([m5C])}$$$$V2.0
1370 RNA1{[lna](G)[sp].[moe](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[moe](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
1371 RNA1{[lna](G)[sp].[moe](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
1372 RNA1{[lna](G)[sp].[moe](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[moe](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
1373 RNA1{[lna](G)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[lna]([m5C])}$$$$V2.0
1374 RNA1{[lna]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1375 RNA1{[lna]([m5C])[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1376 RNA1{[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1377 RNA1{[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1378 RNA1{[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1379 RNA1{[lna]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1380 RNA1{[lna]([m5C])[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1381 RNA1{[lna]([m5C])[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[moe]([m5C])[sp].[moe]([m5C])}$$$$V2.0
1382 RNA1{[lna]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[moe]([m5C])[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1383 RNA1{[lna]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1384 RNA1{[lna](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1385 RNA1{[lna](T)[sp].[moe]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1386 RNA1{[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1387 RNA1{[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1388 RNA1{[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1389 RNA1{[lna](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1390 RNA1{[lna](T)[sp].[moe]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1391 RNA1{[lna](T)[sp].[moe]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1392 RNA1{[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[moe]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1393 RNA1{[lna](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[lna]([m5C])}$$$$V2.0
1394 RNA1{[lna](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[lna]([m5C])}$$$$V2.0
1395 RNA1{[lna](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
1396 RNA1{[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
1397 RNA1{[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
1398 RNA1{[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
1399 RNA1{[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
1400 RNA1{[lna](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[moe](T)[sp].[moe](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[lna]([m5C])}$$$$V2.0
1401 RNA1{[lna](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[fl2r](T)[sp].[lna]([m5C])}$$$$V2.0
1402 RNA1{[lna](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[moe](T)[sp].[moe](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
1403 RNA1{[lna](G)[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[moe](T)[sp].[moe](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[moe](A)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
1404 RNA1{[lna](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](A)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
1405 RNA1{[lna](G)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[lna]([m5C])}$$$$V2.0
1406 RNA1{[lna](G)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
1407 RNA1{[lna](G)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
1408 RNA1{[lna](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
1409 RNA1{[lna](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
1410 RNA1{[lna](G)[sp].[moe](G)[sp].[moe](T)[sp].[moe](G)[sp].[moe](T)[sp].[moe](T)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[moe](T)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
1411 RNA1{[lna](G)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[lna]([m5C])}$$$$V2.0
1412 RNA1{[lna](G)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[fl2r](T)[sp].[lna]([m5C])}$$$$V2.0
1413 RNA1{[lna](G)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
1414 RNA1{[lna](G)[sp].[moe](G)[sp].[moe](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[fl2r]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
1415 RNA1{[lna](G)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](G)[sp].[fl2r](T)[sp].[fl2r](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](G)[sp].[fl2r](T)[sp].[fl2r](A)[sp].[fl2r]([m5C])[sp].[fl2r](T)[sp].[moe](T)[sp].[lna]([m5C])}$$$$V2.0
1416 RNA1{[lna]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
1417 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[lna](G)}$$$$V2.0
1418 RNA1{[lna]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[lna](G)}$$$$V2.0
1419 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[moe](G)}$$$$V2.0
1420 RNA1{[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](A)[sp].[lna](G)}$$$$V2.0
1421 RNA1{[lna]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[lna](A)[sp].[lna](G)}$$$$V2.0
1422 RNA1{[lna]([m5C])[sp].[lna](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](A)[sp].[lna](G)}$$$$V2.0
1423 RNA1{[lna](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)}$$$$V2.0
1424 RNA1{[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)}$$$$V2.0
1425 RNA1{[lna](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)}$$$$V2.0
1426 RNA1{[lna](G)[sp].[lna](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)}$$$$V2.0
1427 RNA1{[moe](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[lna]([m5C])[sp].[lna](T)}$$$$V2.0
1428 RNA1{[lna](G)[sp].[lna](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[lna]([m5C])[sp].[lna](T)}$$$$V2.0
1429 RNA1{[lna](G)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[lna]([m5C])[sp].[lna](T)}$$$$V2.0
1430 RNA1{[lna](G)[sp].[lna](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)}$$$$V2.0
1431 RNA1{[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)}$$$$V2.0
1432 RNA1{[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)}$$$$V2.0
1433 RNA1{[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[moe](T)}$$$$V2.0
1434 RNA1{[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[lna]([m5C])[sp].[lna](T)}$$$$V2.0
1435 RNA1{[lna](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[lna]([m5C])[sp].[lna](T)}$$$$V2.0
1436 RNA1{[lna](T)[sp].[lna](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](G)[sp].[moe](A)[sp].[moe](A)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](T)[sp].[moe](T)[sp].[moe](T)[sp].[moe]([m5C])[sp].[moe](A)[sp].[moe](A)[sp].[moe]([m5C])[sp].[lna](T)}$$$$V2.0
在另一個實施例中，用於本文提供之ASO中的羥基烷氧基或至少一個羥基烷氧基或所有羥基烷氧基包含以下或由以下組成：乙二醇單體、乙二醇寡聚物或乙二醇聚合物(亦稱為聚乙二醇、PEG)。在一個實施例中，ASO與羥基烷氧基之間的鍵聯為共價的。
聚乙二醇化，亦即連接(化學活化之)羥基烷氧基，包括乙二醇單體或鏈，為熟習此項技術者熟知的。聚乙二醇化可在核酸之5'末端單體及/或3'末端單體之–OH基團上進行。此舉可直接或經由間隔基(例如胺基烷基羥基烷氧基)來完成，例如藉由熟習此項技術者已知之點擊化學。
亦涵蓋使用經修飾之羥基烷氧基，包括經修飾之聚乙二醇化，其中該(聚)乙二醇經化學修飾及/或含有與其連接之部分。以此方式，該羥基烷氧基獲得此項技術中已知之額外性質。例如，該羥基烷氧基可變得可裂解或發螢光。經修飾之聚乙二醇化之實例包括但不限於可裂解之聚乙二醇化，其中鍵聯為可降解(可裂解)鍵聯。實例包括響應於例如pH、光、溫度、還原或氧化環境、親核試劑、合成試劑、酶、蛋白酶、組織蛋白酶、點擊釋放反應或(其他)外部刺激之鍵聯。
亦涵蓋使用經修飾之羥基烷氧基聚合物，例如衍生化之PEG支架或PEG-生物模擬物及其架構，包括但不限於線性及二嵌段形式、具有可變臂之輻射星形、樹枝狀聚合物、瓶刷形(bottlebrush)及超支化形式，其中該(聚)乙二醇經過化學修飾及/或含有用於與感興趣之寡核苷酸生物結合的部分。以此方式，聚合物修飾之寡核苷酸具有改進之遞送參數，諸如半衰期及耐久性、寡核苷酸耐受性及安全性以及組織生物分佈，正如其他人所展示的(參見例如Wang 等人, ScienceAdvances 2019, 5(2), www.science.org/doi/10.1126/sciadv.aav9322)。經修飾之聚乙二醇化的實例包括但不限於可裂解之聚乙二醇化，其中PEG與寡核苷酸之間之鍵聯係可降解連接子。實例包括響應於pH、還原或氧化環境、酶、蛋白酶、組織蛋白酶或其他外部刺激之鍵聯。其他連接子考慮因素包括用於增強寡核苷酸溶解度、接近及結合之間隔基，及/或用於遞送額外元件的官能基。此外，聚合物支架亦可設計成增加寡核苷酸藥物密度以及靶向配體之劑量及/或多聚化的比率，以提供高親和力相互作用。此等可以側接臂之統計分佈的形式發生，或以具有聚合物主鏈的確定之分支及臂的形式發生。肌肉靶向之實例包括以下形式：RGD肽(例如環狀及線性)、轉鐵蛋白受體抗體(例如mAb、Fab''、Fab'、ScFv、適體、肽)以及其他人所展示之其他肌肉特異性肽(參見例如Gao 等人, Mol. Ther. 2014, 22(7), 1333-1341, www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)30724-9；Jativa等人, Mol. Pharm. 2019, 16(6), 2376-2384, www.ncbi.nlm.nih.gov/pmc/articles/PMC8008946/；Ruoslahti Ann. Rev. Cell Dev. Biol. 1996, 12, 697-715, 10.1146/annurev.cellbio.12.1.697；Tabebordbar等人, Cell 2021, 184(19), 4919-4938, 10.1016/j.cell.2021.08.028；Desjardins等人, Nucl. Acids Res. 2022, 50(20), 11401-11414, 10.1093/nar/gkac641；Malecova等人, Nucl. Acids Res. 2023, 51(12), 5901-5910, 10.1093/nar/gkad415；及Sugo等人, J. Control. Rel. 2016, 237, 1-13, 10.1016/j.jconrel.2016.06.036。
在一個實施例中，羥基烷氧基為未經修飾之乙二醇單體、乙二醇寡聚物或乙二醇聚合物。在另一個實施例中，羥基烷氧基為經修飾之乙二醇單體、乙二醇寡聚物或乙二醇聚合物(例如，經修飾之PEG)。
在一個實施例中，用於本文提供之ASO中的羥基烷氧基包含或由1、2、3、4、5、6、7、8、9、10、11、12、13、14、15、16、17、18、19或20個乙二醇單體組成。在一些實施例中，羥基烷氧基包含或由1至20、1至16、1至12、1至8、1至6、2至16、2至12、2至8、2至6、3至12、3至8或3至6個乙二醇單體組成。在一些實施例中，羥基烷氧基包含或由1、2、3、4、5、6、7、8、9、10、11或12個乙二醇單體組成。在一些實施例中，羥基烷氧基包含或由3、4、5或6個乙二醇單體組成。在一些實施例中，羥基烷氧基包含或由3或6個乙二醇單體組成。在一些實施例中，羥基烷氧基包含或由3個乙二醇單體組成。
在一個實施例中，羥基烷氧基為二甘醇、三甘醇(TEG)、四甘醇、五甘醇或六甘醇(HEG)基團。在一些實施例中，羥基烷氧基為TEG或HEG。在一些實施例中，羥基烷氧基為TEG。在一些實施例中，羥基烷氧基為HEG。
在本文提供之ASO中，可使用熟習此項技術者熟知之方法將羥基烷氧基連接至ASO。例如，ASO之5'-末端及/或3'-末端OH可經衍生化為亞磷醯胺、氯甲酸酯、氯醯胺或硫代亞磷醯胺，接著與羥基烷氧基(例如二甘醇、三甘醇(TEG)、四甘醇、五甘醇或六甘醇(HEG))在標準偶聯條件下反應以提供羥基烷氧基化之ASO。替代地，羥基烷氧基(例如二甘醇、三甘醇(TEG)、四甘醇、五甘醇或六甘醇(HEG))之OH經衍生化為亞磷醯胺、氯甲酸酯、氯醯胺或硫代亞磷醯胺，接著與ASO之5'-末端及/或3'-末端OH在標準偶聯條件下反應以提供羥基烷氧基化之ASO。
在一個實施例中，羥基烷氧基經由磷酸酯連接子(PO)連接至ASO。在另一個實施例中，羥基烷氧基為TEG基團且羥基烷氧基化之ASO為TEG-PO-ASO (亦即，HO(CH 2CH 2O) 3-P(O)(OH)-ASO)，其中TEG-PO連接至ASO之5'-OH。在另一個實施例中，羥基烷氧基為TEG基團且羥基烷氧基化之ASO為TEG-PO-ASO，其中TEG-PO連接至ASO之3'-OH。在另一個實施例中，兩個TEG基團連接至ASO，一個在3'-OH，且另一個在5'-OH，並且羥基烷氧基化之ASO為(TEG-PO) 2-ASO。
在另一個實施例中，羥基烷氧基經由硫代磷酸酯連接子(PS)連接至ASO。在另一個實施例中，羥基烷氧基為TEG基團且羥基烷氧基化之ASO為TEG-PS-ASO (亦即，HO(CH 2CH 2O) 3-P(S)(OH)-ASO)，其中TEG-PS連接至ASO之5'-OH。在另一個實施例中，羥基烷氧基為TEG基團且羥基烷氧基化之ASO為TEG-PS-ASO，其中TEG-PS連接至ASO之3'-OH。在另一個實施例中，兩個TEG基團連接至ASO，一個在3'-OH，且另一個在5'-OH，並且羥基烷氧基化之ASO為(TEG-PS) 2-ASO。
在另一個實施例中，兩個TEG基團連接至ASO，一個在3'-OH，且另一個在5'-OH，並且羥基烷氧基化之ASO為TEG-PO-ASO-PS-TEG；其中TEG-PO位於5'且TEG-PS位於3'；或者其中TEG-PO位於3'且TEG-PS位於5'。
在另一個實施例中，羥基烷氧基為HEG基團且羥基烷氧基化之ASO為HEG-PO-ASO (亦即，HO(CH 2CH 2O) 6-P(O)(OH)-ASO)，其中HEG-PO連接至ASO之5'-OH。在另一個實施例中，羥基烷氧基為HEG基團且羥基烷氧基化之ASO為HEG-PO-ASO，其中HEG-PO連接至ASO之3'-OH。在另一個實施例中，兩個HEG基團連接至ASO，一個在3'-OH，且另一個在5'-OH，並且羥基烷氧基化之ASO為(HEG-PO) 2-ASO。
在另一個實施例中，羥基烷氧基為HEG基團且羥基烷氧基化之ASO為HEG-PS-ASO (亦即，HO(CH 2CH 2O) 6-P(S)(OH)-ASO)，其中HEG-PS連接至ASO之5'-OH。在另一個實施例中，羥基烷氧基為HEG基團且羥基烷氧基化之ASO為HEG-PS-ASO，其中HEG-PS連接至ASO之3'-OH。在另一個實施例中，兩個HEG基團連接至ASO，一個在3'-OH，且另一個在5'-OH，並且羥基烷氧基化之ASO為(HEG-PS) 2-ASO。
在另一個實施例中，兩個HEG基團連接至ASO，一個在3'-OH，且另一個在5'-OH，並且羥基烷氧基化之ASO為HEG-PO-ASO-PS-HEG；其中HEG-PO位於5'，且HEG-PS位於3'；或者其中HEG-PO位於3'，且HEG-PS位於5'。在另一個實施例中，一個TEG基團及一個HEG基團連接至ASO，一個在3'-OH，且另一個在5'-OH，並且羥基烷氧基化之ASO為TEG-PO-ASO-PS-HEG；其中TEG-PO位於5'，且HEG-PS位於3'；或者其中TEG-PO位於3'，且HEG-PS位於5'。在另一個實施例中，一個TEG基團及一個HEG基團連接至ASO，一個在3'-OH，且另一個在5'-OH，並且羥基烷氧基化之ASO為HEG-PO-ASO-PS-TEG；其中HEG-PO位於5'且TEG-PS位於3'；或者其中HEG-PO位於3'且TEG-PS位於5'。
在另一個實施方案中，本文提供的ASO具有或含有SEQ ID NO: 11、16、76、77、78、79、80、81、110、111、112、113、114、115、177、178、179、180、181、182、183、184、185、186、187、188、189、190、191、192、193、194、195、196、197、198、199、200、201、202、203、204、205、206、207、208、249、250、251、252、265、266、267、268、269、270、271、272、273、274、275、276、277、278、279、295、296、297、298、324、325、 326、327、328、329、330或331之序列。在另一個實施例中，本文提供之ASO 具有或含有SEQ ID NO: 11、16、76、77、78、79、80、81、110、111、112、113、114、115、177、178、179、180、181、182、183、184、185、186、187、188、189、190、191、192、193、194、195、196、197、198、199、200、201、202、203、204、205、206、207、208、249、250、251、252、265、266、267、268、269、270、271、272、273、274、275、276、277、278、279、295、296、297、298、324、325、326、327、328、329、330或331之序列，其中所有胸腺嘧啶鹼基皆經尿嘧啶置換。
在另一個實施例中，本文提供之ASO 具有或含有SEQ ID NO: 347、401、413、452、453、454、455、456、457、470、539、540、592、593、594、595、596、597、612、613、614、624、625、626、627、652、762、809、811、828、829、830、831、832、836、847、848、849、850、851、852、853、854、855、856、857、858、859或860之序列。
在一個實施例中，本文提供之ASO具有本文提供之序列之一，其中自ASO之5'末端省去一個或兩個核苷酸，或其中自ASO之3'末端省去一個或兩個核苷酸，或其中自ASO之5'末端省去一個核苷酸且自ASO之3'末端省去一個核苷酸。因此，在此實施例中，本文提供之ASO為16聚體或17聚體。
在另一個實施例中，本文提供之ASO含有本文提供之序列之一或含有如上所述之16聚體或17聚體，並且長度為16至30個核苷酸。在此等實施例中，熟習此項技術者將能夠基於眾所周知之人類肌萎縮蛋白外顯子53之序列，容易地確定將哪些核苷酸及以何種順序添加至本文提供之序列之5'及/或3'末端，以便獲得長度超過18個核苷酸至最多30個核苷酸且與人類肌萎縮蛋白外顯子53之一部分90%、95%、96%、97%、98%、99%或100%反向互補之ASO。此類更長的ASO在本揭露之範疇內。在另一個實施例中，本文提供之ASO之長度為16至25個核苷酸。在另一個實施例中，本文提供之ASO之長度為16至20個核苷酸。在另一個實施例中，本文提供之ASO之長度為16、17、18、19或20個核苷酸。在另一個實施例中，本文提供之ASO之長度為18個核苷酸。
本文提供之ASO可使用標準固相寡核苷酸合成技術合成。例如，可使用OP-10合成器(GE/ÄKTA Oligopilot)或MerMade 12合成器(BioAutomation)，藉由標準亞磷醯胺方案來合成ASO。ASO可按兩步順序(例如DEA，隨後進行濃NH 4OH處理)裂解及去保護，藉由陰離子交換層析純化，藉由尺寸排阻層析去鹽並凍乾。 III. 醫藥組成物
本文提供之醫藥組成物含有治療有效量的一或多種本文提供之ASO及醫藥學上可接受之載劑、稀釋劑或賦形劑。
ASO可經調配成合適的醫藥製劑，諸如溶液、懸浮液、散劑、用於眼科或非經口投與之無菌溶液或懸浮液，以及經皮貼劑製劑。通常，使用此項技術中熟知之技術及程序將本文所述之ASO調配成醫藥組成物(參見例如Ansel Introduction to Pharmaceutical Dosage Forms，第七版, 1999)。
在組成物中，有效濃度之一或多種化合物或醫藥學上可接受之鹽與合適的醫藥載劑或媒劑混合。在某些實施例中，組成物中ASO之濃度對於遞送在投與後治療、預防或改善本文揭示之疾病或病症之一或多種症狀及/或進展之量係有效的。
通常，組成物經調配以供單劑量投與。為了調配組成物，將重量分率之化合物以使得所治療病狀得到緩解或改善之有效濃度溶解、懸浮、分散或以其他方式混合在選定媒劑中。適用於投與本文提供之ASO的醫藥載劑或媒劑包括熟習此項技術者已知的適用於特定投與方式之任何此類載劑。
此外，ASO可經調配成組成物中唯一的醫藥活性成分或可與其他活性成分組合。脂質體懸浮液，包括組織靶向脂質體，亦可適合作為醫藥學上可接受之載劑。它們可根據熟習此項技術者已知之方法製備。例如，可如此項技術中已知來製備脂質體調配物。簡言之，脂質體諸如多層囊泡(MLV)可藉由在燒瓶內乾燥卵磷脂醯膽鹼及腦磷脂醯絲胺酸(7:3莫耳比)來形成。添加本文提供之化合物在不含二價陽離子之磷酸鹽緩衝鹽水(PBS)中之溶液，並且搖動燒瓶直至脂質薄膜分散。將所得囊泡洗滌以移除未包覆之化合物，藉由離心來沉澱，接著重懸於PBS中。
活性化合物包括在醫藥學上可接受之載劑中，其量足以在對所治療之個體沒有不良副作用的情況下發揮治療有用之作用。治療有效濃度可藉由在本文所述之活體外及活體內系統中測試ASO憑經驗確定，接著由此外推用於人類之劑量。在一些實施例中，ASO係以達成藥物治療有效濃度之方法來投與。在一些實施例中，伴隨診斷(參見，例如，Olsen D及Jorgensen J T, Front. Oncol., 2014年5月16日, 4:105, doi: 10.3389/fonC.2014.00105)用於確定活性化合物在特定個體或個體群體中之治療濃度及安全性概況。
醫藥組成物中ASO之濃度將視以下因素而定：活性化合物之吸收、組織分佈、失活及排泄速率、化合物之理化特徵、給藥時程及投與量以及熟習此項技術者已知之其他因素。例如，遞送之量足以改善本文所揭示之疾病或病症之一或多種症狀。
在某些實施例中，治療有效劑量應產生約0.1 ng/mL至約50-100 μg/mL之活性成分血清濃度。在一個實施例中，醫藥組成物提供每天每公斤體重約0.001 mg至約2000 mg化合物之劑量。製備醫藥劑量單位形式以提供每個劑量單位形式約1 mg至約1000 mg，且在某些實施例中，約10至約500 mg之必需活性成分或必需成分之組合。
ASO可一次性投與，或可分成許多較小劑量而以某一時間間隔來投與。應當理解，精確劑量及治療持續時間隨著所治療疾病而變化並且可使用已知測試方案或藉由自 活體內或 活體外測試資料外推來憑經驗確定。需要注意，濃度及劑量值亦可隨著待緩解之病狀之嚴重程度而變化。進一步應理解，對於任何特定個體，具體給藥方案應根據個體需要及投與或監督組成物投與之人員之專業判斷隨時間調整，並且本文中列出之濃度範圍僅作為示例，並不意欲限制所主張之組成物之範疇或實踐。
因此，將有效濃度或量之一或多種本文所述之ASO或其醫藥學上可接受之鹽與合適的醫藥載劑或媒劑混合以用於全身、表面或局部投與以形成醫藥組成物。ASO係以有效改善一或多種症狀，或用於治療、延緩進展或預防之量包括在內。組成物中活性化合物之濃度將視以下因素而定：活性化合物之吸收、組織分佈、失活、排泄速率、給藥時程、投與量、特定調配物以及熟習此項技術者已知之其他因素。
組成物意欲藉由合適的途徑投與，包括但不限於非經口、皮下、靜脈內、肌肉內、腹膜內、鞘內、真皮、經皮或頰腔。
用於非經口、皮內或皮下應用之溶液或懸浮液可包括以下任何組分：無菌稀釋劑，諸如注射用水、鹽水溶液、不揮發油、聚乙二醇、甘油、丙二醇、二甲基乙醯胺或其他合成溶劑；抗微生物劑，諸如苯甲醇及對羥基苯甲酸甲酯；抗氧化劑，諸如抗壞血酸及亞硫酸氫鈉；螯合劑，諸如乙二胺四乙酸(EDTA)；緩衝劑，諸如乙酸鹽、檸檬酸鹽及磷酸鹽；以及調節滲性之劑，諸如氯化鈉或右旋糖。非經口製劑可封裝在由玻璃、塑膠或其他合適材料製成之安瓿、筆、拋棄式注射器或單劑量或多劑量小瓶中。
在ASO表現出溶解度不足的情況下，可使用溶解ASO之方法。此類方法為熟習此項技術者已知的，並且包括但不限於使用共溶劑諸如二甲亞碸(DMSO)、使用界面活性劑諸如TWEEN®或溶解在碳酸氫鈉水溶液中。
在混合或添加ASO後，所得混合物可為溶液、懸浮液、乳液或其類似物。所得混合物之形式視許多因素而定，包括預期投與方式及ASO在所選載劑或媒劑中之溶解度。有效濃度足以改善所治療之疾病、病症或病狀之症狀並且可憑經驗確定。
醫藥組成物係以單位劑型提供以便向人類及動物投與，該等單位劑型係諸如散劑、顆粒劑、無菌非經口溶液或懸浮液以及油水乳液，其含有適量的ASO或其醫藥學上可接受之鹽。具有醫藥治療活性之ASO及其鹽係以單位劑型或多劑型調配及投與。如本文所用，單位劑型係指適用於人類及動物個體並且如此項技術中已知經單獨包裝的物理上離散之單位。每個單位劑量包含足以與所需醫藥載劑、媒劑或稀釋劑結合來產生所需治療效果的預定量之治療活性化合物。單位劑型之實例包括安瓿及注射器以及單獨包裝之錠劑或膠囊。單位劑型可分次或多次投與。多劑型為包裝在單個容器中之複數個相同單位劑型，以分開的單位劑型投與。多劑型之實例包括小瓶、瓶裝錠劑或膠囊或瓶裝品脫或加侖。因此，多劑型為在包裝中未分開的多重單位劑量。
亦可製備持續釋放製劑。持續釋放製劑之合適實例包括含有本文提供之化合物的固體疏水性聚合物之半透性基質，該等基質呈例如薄膜或微膠囊之成型物件形式。持續釋放基質之實例包括離子電滲法貼劑、聚酯、水凝膠(例如，聚(2-羥乙基-甲基丙烯酸酯)或聚(乙烯醇))、聚丙交酯、L-麩胺酸與L-麩胺酸乙酯之共聚物、非可降解之乙烯-乙酸乙烯酯、可降解之乳酸-乙醇酸共聚物，諸如LUPRON DEPOT™ (由乳酸-乙醇酸共聚物及乙酸亮丙瑞林組成之可注射微球)及聚-D-(-)-3-羥基丁酸。雖然諸如乙烯-乙酸乙烯酯及乳酸-乙醇酸之聚合物能夠釋放分子超過100天，但某些水凝膠釋放蛋白質之時間較短。當經包覆之化合物長時間留在體內時，它們可能會因暴露於37℃之水分而變性或聚集，從而導致生物活性喪失並且其結構可能發生變化。可根據所涉及之作用機制來設計合理策略以實現穩定。例如，若發現聚集機制為經由硫-二硫化物交換形成分子間S--S鍵，則可藉由修飾巰基殘基、自酸性溶液中凍乾、控制水分含量、使用適當添加劑及開發特定聚合物基質組成物來達成穩定化。
可製備含有0.005%至100%活性成分且其餘由無毒載劑組成的劑型或組成物。此類組成物包括溶液、懸浮液、散劑及持續釋放調配物，諸如但不限於植入物及微包覆遞送系統，以及可生物降解、生物相容性聚合物，諸如膠原蛋白、乙烯乙酸乙烯酯、聚酸酐、聚乙醇酸、聚原酸酯、聚乳酸及其他物質。製備此等組成物之方法為熟習此項技術者已知的。所涵蓋之組成物可包含約0.001% 100%之活性成分，在某些實施例中，約0.1 85%或約75-95%。
活性ASO或醫藥學上可接受之鹽可與保護化合物免於自體內快速消除之載劑一起製備，該等載劑係諸如延時釋放調配物或包衣。
該等組成物可包括其他活性ASO以獲得所需之特性組合。為了治療或預防目的，本文提供之ASO或其醫藥學上可接受之鹽亦可有利地與一般此項技術中已知對治療諸如與氧化應激有關之疾病的一或多種上文所述疾病或醫學病狀有價值的另一種醫藥劑一起投與。應當理解，此類組合療法構成本文提供之組成物及治療方法之另一態樣。 A. 可注射劑、溶液及乳液
本文亦涵蓋通常以皮下、肌肉內或靜脈內註射為特徵之非經口投與。可注射劑可以習知形式，亦即作為液體溶液或懸浮液、適合在注射前溶解或懸浮於液體中之固體形式、或作為乳液來製備。在一些實施例中，懸浮液為微粒或奈米粒子之懸浮液。在一些實施例中，乳液為微粒或奈米粒子之乳液。合適的賦形劑例如為水、鹽水、右旋糖、甘油或乙醇。此外，若需要，則待投與之醫藥組成物亦可含有少量無毒輔助物質，諸如潤濕劑或乳化劑、pH緩衝劑、穩定劑、溶解增強劑及其他此類試劑，例如像乙酸鈉、山梨糖醇酐單月桂酸酯、三乙醇胺油酸酯及環糊精。本文亦涵蓋植入緩慢釋放或持續釋放系統，從而維持恆定劑量水準。簡而言之，本文提供之ASO分散在由外部聚合膜包圍的固體內部基質中，該固體內部基質為例如聚甲基丙烯酸甲酯、聚甲基丙烯酸丁酯、塑化或未塑化之聚氯乙烯、塑化耐綸、塑化聚對苯二甲酸乙二酯、天然橡膠、聚異戊二烯、聚異丁烯、聚丁二烯、聚乙烯、乙烯-乙酸乙烯酯共聚物、矽氧橡膠、聚二甲基矽氧烷、矽碳酸酯共聚物、親水性聚合物諸如丙烯酸酯及甲基丙烯酸酯之水凝膠、膠原蛋白、交聯聚乙烯醇及部分水解之交聯聚乙酸乙烯酯，該外部聚合膜為例如聚乙烯、聚丙烯、乙烯/丙烯共聚物、乙烯/丙烯酸乙酯共聚物、乙烯/乙酸乙烯酯共聚物、矽氧橡膠、聚二甲基矽氧烷、氯丁橡膠、氯化聚乙烯、聚氯乙烯、氯乙烯與乙酸乙烯酯之共聚物、偏二氯乙烯、乙烯及丙烯、離子聚合物聚對苯二甲酸乙二酯、丁基橡膠、環氧氯丙烷橡膠、乙烯/乙烯醇共聚物、乙烯/乙酸乙烯酯/乙烯醇三元共聚物、及乙烯/乙烯氧基乙醇共聚物，該外部聚合膜不溶於體液。ASO在釋放速率控制步驟中經由外部聚合膜擴散。此類非經口組成物中所含活性ASO之百分比高度視其具體性質以及化合物之活性及個體之需要而定。
組成物之非經口投與包括靜脈內、皮下及肌肉內投與。用於非經口投與之製劑包括準備註射用之無菌溶液；準備在使用前與溶劑組合之無菌乾燥可溶性產品諸如凍乾散劑，包括皮下注射錠劑；準備註射用之無菌懸浮液；準備在使用前與媒劑組合之無菌乾燥不溶性產品；及無菌乳液。溶液可為水性或非水性的。
若靜脈內投與，則合適的載劑包括生理鹽水或磷酸鹽緩衝鹽水(PBS)，以及含有諸如葡萄糖、聚乙二醇及聚丙二醇及其混合物之增稠劑及增溶劑的溶液。
用於非經口製劑中的醫藥學上可接受之載劑包括水性媒劑、非水性媒劑、抗微生物劑、等滲劑、緩衝劑、抗氧化劑、局部麻醉劑、懸浮劑及分散劑、乳化劑、螯隔劑或螯合劑以及其他醫藥學上可接受之物質。
水性媒劑之實例包括氯化鈉注射液、林格氏注射液、等滲右旋糖注射液、無菌水注射液、右旋糖及乳酸鹽林格氏注射液。非水性非經口媒劑包括植物來源之不揮發油、棉籽油、玉米油、芝麻油及花生油。必須將抑制細菌或抑制真菌濃度之抗微生物劑添加至包裝於多劑量容器中的非經口製劑中，此等製劑包括苯酚或甲酚、汞劑、苯甲醇、氯丁醇、對羥基苯甲酸甲酯及對羥基苯甲酸丙酯、硫柳汞、氯化苯銨及氯化苯索寧。等滲劑包括氯化鈉及右旋糖。緩衝劑包括磷酸鹽及檸檬酸鹽。抗氧化劑包括硫酸氫鈉。局部麻醉劑包括鹽酸普魯卡因。懸浮劑及分散劑包括羧甲基纖維素鈉、羥丙基甲基纖維素及聚乙烯吡咯啶酮。乳化劑包括聚山梨醇酯80 (TWEEN® 80)。金屬離子之螯隔劑或螯合劑包括EDTA。醫藥載劑亦包括用於水溶性媒劑之乙醇、聚乙二醇及丙二醇，以及用於調節pH值之氫氧化鈉、鹽酸、檸檬酸或乳酸。
調整醫藥活性ASO之濃度，以使得注射提供產生所需藥理作用之有效量。確切劑量視如此項技術中已知的個體或動物之年齡、體重及狀況而定。
單位劑量之非經口製劑包裝在安瓿、小瓶或帶針頭之注射器中。如此項技術中已知及實踐，所有用於非經口投與之製劑必須為無菌的。
用作說明地，靜脈內或動脈內輸注含有活性ASO之無菌水溶液為有效投與方式。另一個實施例為含有活性ASO之無菌水性或油性溶液或懸浮液，其根據需要注射以產生所需藥理作用。
可注射劑經設計以用於局部及全身投與。通常，治療有效劑量經調配以含有至少約0.1% w/w至約90% w/w或更高，諸如超過1% w/w之濃度的用於所治療組織之活性ASO。活性ASO可一次性投與，或可分成許多較小劑量而以某一時間間隔來投與。應當理解，精確劑量及治療持續時間隨著所治療組織而變化並且可使用已知測試方案或藉由自活體內或活體外測試資料外推來憑經驗確定。需要注意，濃度及劑量值亦可隨著接受治療之個體之年齡而變化。進一步應理解，對於任何特定個體，具體給藥方案應根據個體需要及投與或監督調配物投與之人員之專業判斷隨時間調整，並且本文中列出之濃度範圍僅作為示例，並不意欲限制所主張之調配物之範疇或實踐。
ASO可以微粉化或其他合適形式懸浮，或者可經衍生化以產生溶解性更大之活性產物或產生前藥。所得混合物之形式視許多因素而定，包括預期投與方式及化合物在所選載劑或媒劑中之溶解度。有效濃度足以改善病狀之症狀並且可憑經驗確定。 B. 凍乾散劑
本文亦提供凍乾散劑，其可經復原以供作為溶液、乳液及其他混合物之投與。它們亦可經復原並調配成固體或凝膠。
藉由將本文提供之ASO或其醫藥學上可接受之鹽溶解於合適的溶劑中來製備無菌凍乾散劑。溶劑可包含改善穩定性之賦形劑或散劑或由散劑製備之復原溶液的其他藥理組分。可使用之賦形劑包括但不限於右旋糖、山梨糖醇、果糖、玉米糖漿、木糖醇、甘油、葡萄糖、蔗糖或其他合適的試劑。在一個實施例中，溶劑亦可包含緩衝劑，諸如檸檬酸鹽、磷酸鈉或磷酸鉀或熟習此項技術者已知的約中性pH下的其他此類緩衝劑。隨後對溶液進行無菌過濾，繼之在熟習此項技術者已知之標準條件下凍乾，提供所需調配物。通常，將所得溶液分裝至小瓶中以便凍乾。每個小瓶將包含單劑量(包括但不限於10-1000 mg或100-500 mg)或多劑量之化合物。凍乾散劑可在適當條件(諸如約4℃至室溫)下儲存。
用注射用水復原此凍乾散劑，提供用於非經口投與之調配物。對於復原，每mL無菌水或其他合適的載劑添加約1-50 mg、約5-35 mg或約9-30 mg之凍乾散劑。精確量視所選化合物而定。此量可憑經驗確定。 C. 表面投與
如局部及全身投與所述來製備表面混合物。所得混合物可為溶液、懸浮液、乳液或其類似物，並經調配成乳膏、凝膠、軟膏、乳液、溶液、酏劑、洗劑、懸浮液、酊劑、糊劑、發泡劑、氣溶膠、灌注劑、噴霧劑、栓劑、繃帶、皮膚貼劑或適合表面投與之任何其他調配物。
化合物可經調配以供局部或表面應用，諸如以凝膠、乳膏及洗劑之形式表面應用於皮膚及黏膜(諸如眼中)，以及應用於眼睛或應用於腦池內或脊柱內。預期表面投與可用於經皮遞送並且亦用於向眼睛或黏膜之投與，或用於吸入療法。亦可單獨或與其他醫藥學上可接受之賦形劑組合投與活性化合物之鼻溶液。
此等溶液，特別是彼等意欲用於眼科用途之溶液，可經調配成含有適當鹽之0.01%-10%等滲溶液，pH值為約5-7。 D. 持續釋放組成物
本文提供之ASO可藉由普通熟習此項技術者熟知之控制釋放方式或遞送裝置來投與。實例包括但不限於在美國專利第3,845,770號；第3,916,899號；第3,536,809號；第3,598,123號；及美國專利第4,008,719號、第5,674,533號、第5,059,595號、第5,591,767號、第5,120,548號、第5,073,543號、第5,639,476號、第5,354,556號、第5,639,480號、第5,733,566號、第5,739,108號、第5,891,474號、第5,922,356號、第5,972,891號、第5,980,945號、第5,993,855號、第6,045,830號、第6,087,324號、第6,113,943號、第6,197,350號、第6,248,363號、第6,264,970號、第6,267,981號、第6,376,461號、第6,419,961號、第6,589,548號、第6,613,358號、第6,699,500號及第6,740,634號中描述之彼等，其各自以引用方式併入本文。此類劑型可用於使用例如羥丙基甲基纖維素、其他聚合物基質、凝膠、可透膜、滲透系統、多層包衣、微粒、脂質體、微球或其組合來提供一或多種活性成分之緩慢釋放或控制釋放，以提供不同比例之所需釋放曲線。可容易選擇普通熟習此項技術者已知之合適的控制釋放調配物，包括本文所述之彼等，以與本文提供之活性成分一起使用。
所有控制釋放醫藥產品均有一個共同目標，即改良藥物療法，使其優於非控制對應體達成之藥物療法。在一個實施例中，在醫學治療中使用優化設計之控制釋放製劑的特徵在於使用最少藥物物質在最短時間內治癒或控制病狀。在某些實施例中，控制釋放調配物之優點包括延長的藥物活性、減少的給藥頻率及提高的個體順從性。此外，控制釋放調配物可用於影響起效時間或其他特徵，諸如藥物之血液濃度，從而可影響副(例如不良)作用之發生。
大多數控制釋放調配物經設計以便最初釋放一定量之藥物(活性成分)，其迅速產生所需治療效果，然後逐漸並繼續釋放其他量之藥物以便在一段較長時間內維持該水準之治療或預防效果。為了在體內維持此恆定藥物水準，藥物自劑型中釋放之速度必須能夠替代藥物自體內代謝及排泄之量。ASO之控制釋放可藉由各種條件來刺激，包括但不限於pH、溫度、酶、水或其他生理條件或化合物。
在某些實施例中，ASO可使用靜脈內輸注、植入式滲透泵、經皮貼劑、脂質體或其他投與方式來投與。在一個實施例中，可使用泵(參見Sefton, CRC Crit. Ref. Biomed. Eng. 14:201 (1987)；Buchwald等人, Surgery 88:507 (1980)；Saudek等人, N. Engl. J. Med. 321:574 (1989)。在另一個實施例中，可使用聚合材料。在又一個實施例中，控制釋放系統可放置在治療靶標附近，亦即因此僅需要全身劑量之一部分(參見，例如，Goodson, Medical Applications of Controlled Release，第2卷，第115-138頁(1984)。
在Langer (Science 249:1527-1533 (1990))之綜述中討論了其他控制釋放系統。ASO可分散在由外部聚合膜包圍的固體內部基質中，該固體內部基質為例如聚甲基丙烯酸甲酯、聚甲基丙烯酸丁酯、塑化或未塑化之聚氯乙烯、塑化耐綸、塑化聚對苯二甲酸乙二酯、天然橡膠、聚異戊二烯、聚異丁烯、聚丁二烯、聚乙烯、乙烯-乙酸乙烯酯共聚物、矽氧橡膠、聚二甲基矽氧烷、矽碳酸酯共聚物、親水性聚合物諸如丙烯酸酯及甲基丙烯酸酯之水凝膠、膠原蛋白、交聯聚乙烯醇及交聯部分水解之聚乙酸乙烯酯，該外部聚合膜為例如聚乙烯、聚丙烯、乙烯/丙烯共聚物、乙烯/丙烯酸乙酯共聚物、乙烯/乙酸乙烯酯共聚物、矽氧橡膠、聚二甲基矽氧烷、氯丁橡膠、氯化聚乙烯、聚氯乙烯、氯乙烯與乙酸乙烯酯之共聚物、偏二氯乙烯、乙烯及丙烯、離子聚合物聚對苯二甲酸乙二酯、丁基橡膠、環氧氯丙烷橡膠、乙烯/乙烯醇共聚物、乙烯/乙酸乙烯酯/乙烯醇三元共聚物、及乙烯/乙烯氧基乙醇共聚物，該外部聚合膜不溶於體液。接著，ASO在釋放速率控制步驟中經由外部聚合膜擴散。此類非經口組成物中所含活性成分之百分比高度視其具體性質以及個體之需要而定。 E. 靶向調配物
本文提供之ASO或其醫藥學上可接受之鹽亦可經調配以靶向待治療個體之特定組織、受體或其他身體區域，包括基於脂質體、再封裝紅血球及抗體之遞送系統。許多此類靶向方法為熟習此項技術者所熟知。本文涵蓋用於本組成物之所有此類靶向方法。對於靶向方法之非限制性實例，參見例如美國專利第6,316,652號、第6,274,552號、第6,271,359號、第6,253,872號、第6,139,865號、第6,131,570號、第6,120,751號、第6,071,495號、第6,060,082號、第6,048,736號、第6,039,975號、第6,004,534號、第5,985,307號、第5,972,366號、第5,900,252號、第5,840,674號、第5,759,542號及第5,709,874號。
在一個實施例中，基於抗體之遞送系統為抗體-藥物結合物(「ADC」)，例如，如Hamilton G S, Biologicals, 2015 September, 43(5):318-32；Kim E G及Kim K M, Biomol. Ther. (Seoul)，2015年11月，23(6):493-509；及Peters C及Brown S, Biosci. Rep., 2015 Jun. 12, 35(4) pii: e00225中所述，其各自以引用方式併入本文。
在一個實施例中，脂質體懸浮液，包括靶向組織之脂質體，諸如靶向腫瘤之脂質體，亦可適合作為醫藥學上可接受之載劑。它們可根據熟習此項技術者已知之方法製備。例如，脂質體調配物可如美國專利第4,522,811號中所述來製備。簡言之，脂質體諸如多層囊泡(MLV)可藉由在燒瓶內部乾燥卵磷脂醯膽鹼與腦磷脂醯絲胺酸(7:3莫耳比)來形成。添加本文提供之ASO於不含二價陽離子之磷酸鹽緩衝鹽水(PBS)中之溶液，並且搖動燒瓶直至脂質薄膜分散。將所得囊泡洗滌以移除未包覆之化合物，藉由離心來沉澱，接著重懸於PBS中。 F. 製造物件
ASO或醫藥學上可接受之鹽可經包裝成製造物件，該等製造物件含有包裝材料；用於治療、預防或改善本文所揭示之疾病或病症之一或多種症狀或進展的本文提供之ASO或其醫藥學上可接受之鹽；以及指示化合物或其醫藥學上可接受之鹽用於治療、預防或改善本文所揭示之疾病或病症之一或多種症狀或進展的標籤。
本文提供之製造物件包含包裝材料。用於包裝醫藥產品之包裝材料為熟習此項技術者所熟知。參見，例如美國專利第5,323,907號、第5,052,558號及第5,033,252號。醫藥包裝材料之實例包括但不限於泡鼓包裝、瓶子、管子、吸入器、泵、袋子、小瓶、容器、注射器、筆、瓶子以及任何適用於所選調配物及預期投與及治療方式之包裝材料。涵蓋本文提供之ASO及組成物之眾多調配物。
在某些實施例中，本文亦提供套組，該套組當由執業醫師使用時，可簡化適量ASO向個體之投與。在某些實施例中，本文提供之套組包括容器及本文提供之ASO或其醫藥學上可接受之鹽、溶劑合物或前藥之劑型。
在某些實施例中，套組包括一個容器，該容器包含本文提供之ASO或其醫藥學上可接受之鹽、溶劑合物或前藥的劑型，在該容器中包含一或多種本文所述之其他治療劑。
本文提供之套組可進一步包括用於投與ASO之裝置。此類裝置之實例包括但不限於注射器、無針注入器滴袋、貼劑及吸入器。
本文提供之套組可進一步包括可用於投與一或多種活性成分的醫藥學上可接受之媒劑。例如，若活性成分以必須經復原用於非經口投與之固體形式提供，則套組可包含合適媒劑之密封容器，活性成分可在該媒劑中溶解以形成適用於非經口投與的無顆粒之無菌溶液。醫藥學上可接受之媒劑之實例包括但不限於：水性媒劑，包括但不限於注射用水USP、氯化鈉注射液、林格氏注射液、右旋糖注射液、右旋糖及氯化鈉注射液以及乳酸鹽林格氏注射液；水溶性媒劑，包括但不限於乙醇、聚乙二醇及聚丙二醇；以及非水性媒劑，包括但不限於玉米油、棉籽油、花生油、芝麻油、油酸乙酯、肉荳蔻酸異丙酯及苯甲酸芐酯。 IV. 給藥
本文提供之ASO及醫藥組成物可以如下所述之某些治療或預防有效量、某些時間間隔、某些劑型及某些劑量投與方法來給予。
在某些實施例中，ASO之治療或預防有效量為每天約0.005至約1,000 mg、每天約0.01至約500 mg、每天約0.01至約250 mg、每天約0.01至約100 mg、每天約0.1至約100 mg、每天約0.5至約100 mg、每天約1至約100 mg、每天約0.01至約50 mg、每天約0.1至約50 mg、每天約0.5至約50 mg、每天約1至約50 mg、每天約0.02至約25 mg、每天約0.05至約10 mg、每天約0.05至約5 mg、每天約0.1至約5 mg、或每天約0.5至約5 mg。
在某些實施例中，治療或預防有效量為每天約0.1、約0.2、約0.5、約1、約2、約3、約4、約5、約6、約7、約8、約9、約10、約15、約20、約25、約30、約40、約45、約50、約60、約70、約80、約90、約100或約150 mg。
在一個實施例中，本文提供之ASO或其衍生物用於本文所述病狀之推薦每日劑量範圍在每天約0.5 mg至約50 mg之範圍內，在一個實施例中，作為單一的每日一次劑量或全天分次劑量來給予。在一些實施例中，劑量範圍為每天約1 mg至約50 mg。在其他實施例中，劑量範圍為每天約0.5至約5 mg。每天的具體劑量包括每天0.1、0.2、0.5、1、2、3、4、5、6、7、8、9、10、11、12、13、14、15、16、17、18、19、20、21、22、23、24、25、26、27、28、29、30、31、32、33、34、35、36、37、38、39、40、41、42、43、44、45、46、47、48、49或50 mg。
在一個具體實施例中，推薦起始劑量可為每天0.5、1、2、3、4、5、10、15、20、25或50 mg。在另一個實施例中，推薦起始劑量可為每天0.5、1、2、3、4或5 mg。劑量可遞增至每天15、20、25、30、35、40、45及50 mg。在一個具體實施例中，ASO可以每天約25 mg之量投與。在一個特定實施例中，ASO可以每天約10 mg之量投與。在一個特定實施例中，ASO可以每天約5 mg之量投與。在一個特定實施例中，ASO可以每天約4 mg之量投與。在一個特定實施例中，ASO可以每天約3 mg之量投與。
在某些實施例中，治療或預防有效量為約0.001至約100 mg/kg/天、約0.01至約50 mg/kg/天、約0.01至約25 mg/kg/天、約0.01至約10 mg/kg/天、約0.01至約9 mg/kg/天、0.01至約8 mg/kg/天、約0.01至約7 mg/kg/天、約0.01至約6 mg/kg/天、約0.01至約5 mg/kg/天、約0.01至約4 mg/kg/天、約0.01至約3 mg/kg/天、約0.01至約2 mg/kg/天、約0.01至約1 mg/kg/天、或約0.01至約0.05 mg/kg/天。
所投與之劑量亦可用除mg/kg/天以外之單位表示。例如，非經口投與之劑量可用mg/m 2/天表示。普通熟習此項技術者易於知曉如何鑒於個體之身高或體重或這兩者將劑量自mg/kg/天轉換為mg/m 2/天(參見www.fda.gov/cder/cancer/animalframe.htm)。例如，對於65 kg之人，1 mg/kg/天之劑量大致等於38 mg/m 2/天。
在某些實施例中，所投與的ASO之量足以提供在約0.001至約500 µM、約0.002至約200 µM、約0.005至約100 µM、約0.01至約50 µM、約1至約50 µM、約0.02至約25 µM、約0.05至約20 µM、約0.1至約20 µM、約0.5至約20 µM、或約1至約20 µM範圍內的化合物之穩態血漿濃度。
在其他實施例中，所投與的ASO之量足以提供在約5至約100 nM、約5至約50 nM、約10至約100 nM、約10至約50 nM或約50至約100 nM範圍內的化合物之穩態血漿濃度。
如本文所用，術語「穩態血漿濃度」為在投與本文提供之化合物或其衍生物一段時間後達到之濃度。一旦達到穩態，化合物之血漿濃度隨時間變化之曲線上就會出現小峰及小谷。
在某些實施例中，所投與的ASO之量足以提供在約0.001至約50 µM、約0.002至約200 µM、約0.005至約100 µM、約0.01至約50 µM、約1至約50 µM、約0.02至約25 µM、約0.05至約20 µM、約0.1至約20 µM、約0.5至約20 µM、或約1至約20 µM範圍內的化合物之最大血漿濃度(峰濃度)。
在某些實施例中，所投與的ASO之量足以提供在約0.001至約500 µM、約0.002至約200 µM、約0.005至約100 µM、約0.01至約50 µM、約1至約50 µM、約0.01至約25 µM、約0.01至約20 µM、約0.02至約20 µM、約0.02至約20 µM、或約0.01至約20 µM範圍內的化合物之最小血漿濃度(谷濃度)。
在某些實施例中，所投與的ASO之量足以提供在約100至約100,000 ng*hr/mL、約1,000至約50,000 ng*hr/mL、約5,000至約25,000 ng*hr/mL、或約5,000至約10,000 ng*hr/mL範圍內的化合物之曲線下面積(AUC)。
本文提供之方法涵蓋治療患者而不考慮個體之年齡，儘管一些疾病或病症在某些年齡組中更常見。
根據待治療之疾病及個體之狀況，本文提供之ASO或其衍生物可藉由非經口(例如，肌肉內、腹膜內、靜脈內、CIV、腦池內註射或輸注、皮下注射或植入)或表面(例如，經皮或局部)投與途徑來投與。本文提供之ASO或其衍生物可單獨或在合適的劑量單位中與適用於每種投與途徑的醫藥學上可接受之賦形劑、載劑、佐劑及媒劑一起調配。
在另一個實施例中，本文提供之ASO或其衍生物係非經口投與的。在又一個實施例中，本文提供之ASO或其衍生物係靜脈內投與的。
本文提供之ASO或其衍生物可作為單次劑量遞送，例如單次彈丸注射，或隨時間遞送，例如隨時間連續輸注或隨時間分次彈丸劑量。如有必要，則可重複投與ASO，例如，直至個體經歷穩定的疾病或消退，或直至個體經歷疾病進展或不可接受之毒性。
本文提供之ASO或其衍生物可每日一次(QD)投與，或分為多次每日劑量，諸如每日兩次(BID)、每日三次(TID)及每日四次(QID)。此外，投與可為連續的(亦即每日投與連續幾天或每天)、間歇的，例如週期性的(亦即包括數天、數週或數月的無藥物休止期)。如本文所用，術語「每日」意欲表示治療性化合物，諸如本文提供之化合物或其衍生物，每天投與一次或多次，例如，持續一段時間。術語「連續」意欲表示治療性化合物，諸如本文提供之化合物或其衍生物，在至少10天至52週之不間斷時期內每日投與。如本文所用，術語「間歇」或「間歇地」意欲表示以規則或不規則之間隔停止及開始。例如，本文提供之ASO或其衍生物之間歇投與為每週投與一至六天，週期性投與(例如，每日投與，連續二至八週，繼之以至多一週之無投藥休止期)，或隔日投與。如本文所用，術語「週期」意欲表示治療性化合物，諸如本文提供之化合物或其衍生物，每日或連續地投與，但有休止期。在一些此類實施例中，投與為每天一次持續二至六天，繼之為五至七天之無投與休止期。
在一些實施例中，投與頻率在約每日劑量至約每月劑量之範圍內。在某些實施例中，投與為每天一次、每天兩次、每天三次、每天四次、每隔一天一次、每週兩次、每週一次、每兩週一次、每三週一次或每四週一次。在一個實施例中，本文提供之化合物或其衍生物每天投與一次。在另一個實施例中，本文提供之ASO或其衍生物每天投與兩次。在又一個實施例中，本文提供之ASO或其衍生物每天投與三次。在仍另一個實施例中，本文提供之ASO或其衍生物每天投與四次。
在某些實施例中，本文提供之ASO或其衍生物每天投與一次，持續一天至六個月、一週至三個月、一週至四週、一週至三週、或一週至兩週。在某些實施例中，本文提供之ASO或其衍生物每天投與一次，持續一週、兩週、三週或四週。在一個實施例中，本文提供之ASO或其衍生物每天投與一次，持續4天。在一個實施例中，本文提供之ASO或其衍生物每天投與一次，持續5天。在一個實施例中，本文提供之ASO或其衍生物每天投與一次，持續6天。在一個實施例中，本文提供之ASO或其衍生物每天投與一次，持續一週。在另一個實施例中，本文提供之ASO或其衍生物每天投與一次，持續兩週。在另一個實施例中，本文提供之ASO或其衍生物每天投與一次，持續三週。在另一個實施例中，本文提供之ASO或其衍生物每天投與一次，持續四週。 V. 治療方法
在另一個實施例中，提供一種治療患有杜顯氏肌肉萎縮症(DMD)之個體的方法。在一個實施例中，該方法包括向個體投與本文提供之ASO或組成物之步驟。在另一個實施例中，提供一種藉由投與本文提供之ASO或組成物來延遲DMD發作之方法。在另一個實施例中，該方法減輕DMD之一或多種症狀。
使用本文提供之ASO減輕個體之DMD之一或多種症狀可藉由以下任何檢定來評估：進展至無法行走之時間的延長、肌肉力量之改善、舉重能力之改善、從地板上站起來之時間的改善、九米步行時間之改善、爬四層樓梯所需時間之改善、腿部功能等級之改善、肺功能之改善、心臟功能之改善、生活品質之改善。此等檢定各自均為熟習此項技術者已知。對於此等檢定中之各者，一旦發現在檢定中量測之參數之可偵測改善或延長，此將較佳意味著DMD之一或多種症狀已使用本文提供之ASO在個體中得到緩解。在一個實施例中，可偵測之改善或延長為統計學上顯著之改善或延長，如Hodgetts等人Neuromuscular Disorders 2006; 16: 591-602中所述。或者，可藉由量測肌纖維功能、完整性及/或存活之改善來評估DMD之一或多種症狀之緩解。在另一個實施例中，DMD患者之一或多種症狀得到緩解及/或來自DMD患者之一或多種肌肉細胞之一或多種特徵得到改善。此類症狀或特徵可在細胞、組織層面或在患者自身上進行評估。
可藉由對來自患者之肌原細胞或肌肉細胞進行以下任何檢定來評估來自患者之肌肉細胞的一或多種特徵之緩解：肌肉細胞對鈣之攝取減少、膠原蛋白合成減少、形態改變、脂質生物合成改變、氧化應激減少及/或肌纖維功能、完整性及/或存活改善。此等參數通常使用肌肉生檢橫截面之免疫螢光及/組織化學分析來評估。
肌纖維功能、完整性及/或存活之改善可使用至少一種以下檢定來評估：血液中肌酸激酶之可偵測減少，疑似營養不良之肌肉生檢橫截面中肌纖維壞死之可偵測減少，及/或在疑似營養不良之肌肉之生檢橫截面中肌纖維直徑均勻性之可偵測增加。此等檢定各自均為熟習此項技術者已知。
如Hodgetts等人(2006)所述，可在血液中偵測到肌酸激酶。肌酸激酶之可偵測減少可意謂與治療前之同一DMD患者之肌酸激酶濃度相比，減少5%、10%、20%、30%、40%、50%、60%、70%、80%、90%或更多。
肌纖維壞死之可偵測減少較佳在肌肉生檢中，更佳如Hodgetts等人(2006)中所述，使用生檢橫截面來評估。壞死之可偵測減少可為區域減少5%、10%、20%、30%、40%、50%、60%、70%、80%、90%或更大，其中壞死已使用生檢橫截面來鑑定。藉由與治療前在同一DMD患者中評估之壞死進行比較來量測減少。
較佳在肌肉生檢橫截面中，更佳如Hodgetts等人( 同上)所述評估肌纖維直徑均勻性之可偵測增加。藉由與治療前在同一DMD患者中肌纖維直徑之均勻性進行比較來量測增加。
在一個實施例中，本文提供之ASO為該個體提供功能性或半功能性肌萎縮蛋白，並且能夠至少部分地減少該個體中異常肌萎縮蛋白之產生。
在一個實施例中，為個體提供功能性或半功能性肌萎縮蛋白意謂功能性或半功能性肌萎縮蛋白之產生增加。增加功能性或半功能性肌萎縮蛋白mRNA或功能性或半功能性肌萎縮蛋白之產生意謂與功能性或半功能性mRNA，或功能性或半功能性肌萎縮蛋白之初始量相比，可偵測到之增加或至少5%、10%、20%、30%、40%、50%、60%、70%、80%、90%、100%、120%、140%、160%、180%、200%或更多，如可藉由RT-數位微滴PCR (mRNA) (Verheul等人，PLoS ONE 2016, 11(9):e0162467)或免疫螢光法(Beekman等人，PLoS ONE 2014; 9(9): e107494)、西方墨點法或毛細管西方免疫檢定(Beekman等人，PLoS ONE 2018; 13(4): e0195850)分析(蛋白質)所偵測。在另一個實施例中，該初始量為使用本發明化合物，在細胞、器官、組織中及/或在個體中開始誘導肌萎縮蛋白前驅mRNA之外顯子跳躍時，功能性或半功能性mRNA、或功能性或半功能性肌萎縮蛋白之量。
減少異常肌萎縮蛋白mRNA或異常肌萎縮蛋白之產生意謂異常肌萎縮蛋白mRNA或異常肌萎縮蛋白之初始量90%、80%、70%、60%、50%、40%、30%、20%、10%、5%或更少仍可藉由RT數位微滴PCR (mRNA)或免疫螢光法、西方墨點法或毛細管西方免疫檢定(Wes)分析(蛋白質)來偵測。在一個實施例中，該初始量為使用本發明之ASO，在細胞、器官、組織中及/或在個體中開始誘導肌萎縮蛋白前驅mRNA之外顯子跳躍時，異常肌萎縮蛋白mRNA或異常肌萎縮蛋白之量。異常肌萎縮蛋白mRNA或蛋白在本文中亦稱為功能較弱(與野生型功能性肌萎縮蛋白相比)或非功能性肌萎縮蛋白mRNA或蛋白質。非功能性肌萎縮蛋白為不能結合肌動蛋白及/或DGC蛋白複合物之成員的肌萎縮蛋白。非功能性肌萎縮蛋白或肌萎縮蛋白mRNA通常不具有或不編碼具有蛋白之完整C末端的肌萎縮蛋白。功能性或半功能性肌萎縮蛋白mRNA或蛋白之偵測可像偵測異常肌萎縮蛋白mRNA或蛋白一樣進行。
一旦為DMD患者提供功能性或半功能性肌萎縮蛋白，至少部分DMD病因便消除。因此，預計DMD之症狀至少部分會緩解，或者症狀惡化之速度會降低，導致衰弱減慢。增加的跳躍頻率亦提高DMD個體之肌肉細胞中產生的功能性或半功能性肌萎縮蛋白之水準。 VI. 與第二活性劑之組合療法
本文提供之ASO或其衍生物亦可與可用於治療及/或預防DMD之其他治療劑組合或組合使用。
在一個實施例中，本文提供一種治療、預防或控制DMD之方法，其包括向個體投與同一或多種第二活性劑組合的本文提供之ASO或其衍生物。
如本文所用，術語「與…組合」包括使用多於一種療法(例如，一或多種預防劑及/或治療劑)。然而，術語「與…組合」之使用不限制療法(例如，預防劑及/或治療劑)向患有疾病或病症之個體投與的順序。第一療法(例如，預防劑或治療劑，諸如本文提供之ASO)可在向個體投與第二療法(例如，預防劑或治療劑)之前(例如，5分鐘、15分鐘、30分鐘、45分鐘、1小時、2小時、4小時、6小時、12小時、24小時、48小時、72小時、96小時、1週、2週、3週、4週、5週、6週、8週或12週之前)、同時或之後(例如，5分鐘、15分鐘、30分鐘、45分鐘、1小時、2小時、4小時、6小時、12小時、24小時、48小時、72小時、96小時、1週、2週、3週、4週、5週、6週、8週或12週之後)投與。本文亦涵蓋三聯療法。
本文提供之ASO或其衍生物及一或多種第二活性劑向個體之投與可藉由相同或不同投與途徑同時或依次進行。用於特定活性劑之特定投與途徑之適用性將視活性劑本身(例如，它是否可經口投與而不在進入血流之前分解)及正在治療之疾病或病症而定。
本文提供之ASO或其衍生物之投與途徑獨立於第二療法之投與途徑。在另一實施例中，本文提供之ASO或其衍生物係靜脈內投與的。因此，根據此等實施例，本文提供之ASO或其衍生物係靜脈內投與，並且第二療法可經口、非經口、腹膜內、靜脈內、動脈內、經皮、舌下、肌肉內、直腸、經頰、鼻內、脂質體、經由吸入、陰道、眼內、經由導管或支架之局部遞送、皮下、脂肪內、關節內、鞘內或以緩慢釋放劑型投與。在一個實施例中，本文提供之ASO或其衍生物與第二療法藉由相同投與方式投與，例如藉由IV投與。在另一個實施例中，本文提供之ASO或其衍生物係藉由一種投與方式投與，例如藉由IV投與，而第二劑係藉由另一種投與方式投與，例如經口投與。
在一個實施例中，第二活性劑靜脈內或皮下且以約1至約1000 mg、約5至約500 mg、約10至約350 mg、或約50至約200 mg之量每日投與一次或兩次。第二活性劑之具體量將視以下因素而定：所使用之具體劑、正在治療或控制之疾病類型、疾病之嚴重性及階段、以及本文提供之ASO或其衍生物之量、以及同時向個體投與之任何視情況可用的額外活性劑。
在本文提供之方法及組成物中，一或多種第二活性成分或劑可與本文提供之ASO或其衍生物一起使用。第二活性劑可為大分子(例如蛋白質)或小分子(例如合成無機、有機金屬或有機分子)。
大分子活性劑之實例包括但不限於造血生長因子、細胞介素、ASO以及單株及多株抗體。典型大分子活性劑為生物分子，諸如天然存在或合成或重組蛋白質。用於本文之具體實例包括依特立生、卡西莫森、戈洛迪森、維托拉森及SRP-5051 (Sarepta Therapeutics)。
小分子之實例包括皮質類固醇，諸如地夫可特(deflazacort)。
可與本文提供之ASO組合之其他療法包括基因療法(例如，SRP-9001、GALGT2或GNT 0004 (Sarepta Therapeutics))、基因編輯(例如，CRISPR/CAS9 (Sarepta Therapeutics))及細胞療法(例如，CAP-1002 (Capricor Therapeutics/Nippon Shinyaku Co. Ltd.))。 VII. 實例
以下實例旨在說明本文所提供之某些實施例，但不限制本揭露之範疇。 實例1
使用具有外顯子52缺失之KM571人類永生化肌母細胞株作為模型系統。KM571細胞預先使用hTERT及CDK4 (PMID: 22040608)永生化。在第1天，在存在1.4微莫耳個別寡核苷酸之情況下，對每孔100,000個細胞進行核轉染(Lonza，設置DS-150，SF溶液)，接著用骨骼肌生長培養基(PromoCell (目錄號：C-23060)，最終體積12.5% HI-FBS及100單位/毫升Pen/Strep)稀釋10倍，且接著轉移至96孔組織培養板中。第4天，使用TaqMan Gene Expression Cells-to-CT (Thermo Fisher Scientific，55微升最終溶解體積)收集細胞，反轉錄10微升RNA，且接著藉由qPCR評估4微升所得cDNA (跳躍正向引子5’-GGTGGGTGACCTTGAGGAT-3’ (SEQ ID NO: 1437)、跳躍探針5’-ATCATCAAGCAGAAGCAGTTGGCC-3’ (SEQ ID NO: 1438)及跳躍反向引子5’-GCCAAGTCATTTGCCACATCTA-3’ (SEQ ID NO: 1439))。使用跳躍之擴增子(IDT，外顯子51剪接至外顯子54)之雙股DNA片段驗證檢定並量化未知樣品中之拷貝數(以SEQ ID NO: 332-391之平均拷貝數e51-54報導)。所顯示的資料亦顯示為外顯子53跳躍相對於陽性對照ASO (SEQ ID NO: 392-846)之倍數變化。 結果
SEQ ID NO: 平均拷貝數e51-54 SEQ ID NO: 平均拷貝數e51-54
332 18.46044 362 35.90505
333 28.57523 363 29.72139
334 52.43133 364 38.61757
335 33.74944 365 29.21741
336 30.13969 366 16.76273
337 23.89664 367 33.81896
338 21.05017 368 22.58539
339 43.50294 369 34.77628
340 63.29167 370 34.91955
341 110.6124 371 62.08335
342 108.6631 372 58.5308
343 48.1524 373 42.37498
344 70.25501 374 39.97476
345 60.53615 375 33.90953
346 85.42719 376 37.85591
347 159.6615 377 33.0423
348 99.35136 378 27.9666
349 124.601 379 43.00257
350 55.85621 380 34.50121
351 46.54202 381 79.92295
352 50.65856 382 36.55703
353 71.15927 383 38.47768
354 79.19031 384 74.43272
355 43.63413 385 34.42958
356 48.61327 386 34.3297
357 63.02238 387 23.03655
358 89.28076 388 35.14468
359 101.811 389 36.06588
360 34.75905 390 33.00826
361 75.3985 391 33.46939
SEQ ID NO: 平均倍數變化 SEQ ID NO: 平均倍數變化
392 0.12789 620 0.402322
393 0.13138 621 0.225326
394 0.099902 622 0.2918
395 0.181408 623 0.676989
396 0.166265 624 0.718245
397 0.099934 625 1.016323
398 0.010325 626 0.699593
399 0.039361 627 0.639157
400 0.149986 628 0.602432
401 0.631706 629 0.614251
402 0.403679 630 0.270208
403 0.1352 631 0.115875
404 0.117861 632 0.232468
405 0.0904 633 0.459435
406 0.05062 634 0.437206
407 0.139661 635 0.61444
408 0.094497 636 0.188392
409 0.040174 637 0.405305
410 0.111435 638 0.290901
411 0.26025 639 0.678393
412 0.610883 640 0.761975
413 1.012774 641 0.780472
414 0.485686 642 0.775587
415 0.28601 643 0.646567
416 0.278988 644 0.479225
417 0.320944 645 0.076825
418 0.114375 646 0.169707
419 0.163052 647 0.590007
420 0.189847 648 0.324063
421 0.294068 649 0.190573
422 0.159571 650 0.314454
423 0.236029 651 0.395139
424 0.133519 652 1.156984
425 0.166776 653 0.14452
426 0.110905 654 0.33398
427 0.120288 655 0.274171
428 0.079664 656 0.15043
429 0.048326 657 0.37375
430 0.065412 658 0.148435
431 0.114474 659 0.217535
432 0.048914 660 0.214928
433 0.090585 661 0.249702
434 0.0664 662 0.217745
435 0.03668 663 0.093558
436 0.040513 664 0.285438
437 0.042958 665 0.144098
438 0.050075 666 0.267208
439 0.059613 667 0.236559
440 0.055411 668 0.138315
441 0.092556 669 0.122713
442 0.087263 670 0.160543
443 0.189697 671 0.149386
444 0.154739 672 0.159719
445 0.116972 673 0.105695
446 0.128381 674 0.148312
447 0.298654 675 0.097911
448 0.126215 676 0.112123
449 0.285149 677 0.78351
450 0.173892 678 0.694092
451 0.374944 679 0.295124
452 0.464187 680 0.308716
453 0.599866 681 0.762757
454 0.549928 682 0.500033
455 1.628684 683 0.370103
456 1.066097 684 0.888612
457 1.282981 685 0.098633
458 0.302204 686 0.927681
459 0.356965 687 0.813528
460 0.260187 688 0.143951
461 0.489771 689 0.260316
462 0.379749 690 0.636231
463 0.505569 691 0.395169
464 0.984469 692 0.326766
465 0.671754 693 0.125239
466 0.871486 694 1.537567
467 0.353531 695 1.021724
468 0.275883 696 1.103078
469 0.43617 697 0.777753
470 0.442532 698 0.791486
471 0.346929 699 0.883798
472 0.180567 700 0.900414
473 0.204937 701 0.311729
474 0.096495 702 0.181284
475 0.160915 703 0.143289
476 0.214371 704 0.064378
477 0.178929 705 0.16426
478 0.166159 706 0.223649
479 0.252055 707 0.258268
480 0.155495 708 0.319309
481 0.162084 709 0.260845
482 0.076661 710 0.159328
483 0.072392 711 0.657512
484 0.107182 712 0.225481
485 0.143409 713 0.429417
486 0.100518 714 0.705218
487 0.140252 715 0.290625
488 0.212131 716 0.241281
489 0.193038 717 0.574336
490 0.091341 718 0.330863
491 0.162475 719 0.482342
492 0.189492 720 0.262855
493 0.124972 721 0.192895
494 0.147759 722 0.241698
495 0.067958 723 0.151071
496 0.05222 724 0.280897
497 0.041031 725 0.090384
498 0.047479 726 0.234182
499 0.055796 727 0.073217
500 0.075652 728 0.107552
501 0.150396 729 0.10433
502 0.053813 730 0.213264
503 0.06741 731 0.128794
504 0.082688 732 0.217298
505 0.063553 733 0.116695
506 0.047319 734 0.105983
507 0.062183 735 0.273206
508 0.057136 736 0.203489
509 0.082544 737 0.108869
510 0.11539 738 0.391031
511 0.118449 739 0.394769
512 0.076636 740 0.355355
513 0.047198 741 0.341742
514 0.034985 742 0.114805
515 0.047534 743 0.212071
516 0.088652 744 0.12881
517 0.112728 745 0.193224
518 0.16193 746 0.093948
519 0.038279 747 0.11066
520 0.048701 748 0.128907
521 0.053126 749 0.096421
522 0.380014 750 0.152729
523 0.284973 751 0.133725
524 0.194449 752 0.192827
525 0.161759 753 0.109911
526 0.144795 754 0.132019
527 0.123155 755 0.108438
528 0.188829 756 0.175814
529 0.271993 757 0.114354
530 0.245637 758 0.075463
531 0.220223 759 0.719376
532 0.170368 760 0.619404
533 0.157116 761 0.668351
534 0.164245 762 0.569775
535 0.822143 763 0.350729
536 0.625475 764 0.675005
537 0.529811 765 0.951022
538 0.452193 766 0.524659
539 0.21462 767 0.152452
540 0.802684 768 0.212426
541 0.04091 769 0.114684
542 0.045338 770 0.21805
543 0.035998 771 0.420339
544 0.059436 772 0.351305
545 0.063346 773 0.115685
546 0.066143 774 0.196322
547 0.053158 775 0.274337
548 0.04794 776 0.239263
549 0.046061 777 0.069587
550 0.044528 778 0.139793
551 0.041468 779 0.139015
552 0.041589 780 0.131708
553 0.472232 781 0.372504
554 0.597603 782 0.301299
555 0.490883 783 0.338446
556 0.505865 784 0.116848
557 0.389558 785 0.074125
558 0.503517 786 0.501036
559 0.407523 787 0.22936
560 0.401459 788 0.046529
561 0.255044 789 0.117119
562 0.520983 790 0.29552
563 0.534194 791 0.338185
564 0.6011 792 0.15633
565 0.506029 793 0.456109
566 0.548652 794 0.332829
567 0.651565 795 0.234751
568 0.591832 796 0.131613
569 0.55572 797 0.082187
570 0.518361 798 0.227411
571 0.320449 799 0.249635
572 0.582818 800 0.039127
573 0.7425 801 0.099556
574 0.623199 802 0.120163
575 0.162095 803 0.075064
576 0.151989 804 0.130462
577 0.17483 805 0.11331
578 0.188683 806 0.079364
579 0.276645 807 0.110502
580 0.130648 808 0.166745
581 0.125549 809 0.330695
582 0.080788 810 0.246583
583 0.044321 811 0.222047
584 0.100526 812 0.140775
585 0.220351 813 0.127088
586 0.301256 814 0.126184
587 0.192472 815 0.076421
588 0.104424 816 0.144628
589 0.172923 817 0.186798
590 0.106008 818 0.122567
591 0.23035 819 0.062306
592 0.606225 820 0.308397
593 0.502292 821 0.30584
594 0.317446 822 0.342048
595 0.493078 823 0.217299
596 0.438866 824 0.160211
597 0.325522 825 0.133078
598 0.252568 826 0.111217
599 0.247371 827 0.136336
600 0.17562 828 0.58203
601 0.109506 829 0.910387
602 0.15316 830 0.906905
603 0.346635 831 0.648106
604 0.231105 832 0.800597
605 0.396636 833 0.578644
606 0.146176 834 0.267947
607 0.387703 835 0.423202
608 0.14511 836 0.430351
609 0.299143 837 0.337858
610 0.202447 838 0.097618
611 0.426063 839 0.110964
612 0.611141 840 0.094772
613 0.502614 841 1.199796
614 0.601975 842 0.07592
615 0.223962 843 0.602545
616 0.230348 844 0.049966
617 0.097939 845 0.106455
618 0.10477 846 0.154013
619 0.297694
實例2
使用具有外顯子52缺失之KM1328人類永生化肌母細胞株作為模型系統。KM1328細胞預先使用hTERT及CDK4 (PMID: 22040608)永生化。第-2天，每孔以骨骼肌生長培養基(PromoCell (目錄號：C-23060)，最終體積12.5% HI-FBS及10,000單位/毫升Pen/Strep)接種25,000個細胞。在第0天，將骨骼肌生長培養基更換為骨骼肌分化培養基(DMEM Gibco 11054020，最終體積2% HI-FBS及10,000單位/毫升Pen/Strep)。第4天，將10微莫耳之個別寡核苷酸以分化培養基稀釋，並轉移至所需孔中作為第一次處理。第7天，將10微莫耳之個別寡核苷酸以分化培養基稀釋，並轉移至所需孔中作為第二次處理。第10天，使用TaqMan Gene Expression Cells-to-CT (Thermo Fisher Scientific，55微升最終溶解體積)收集細胞，反轉錄10微升RNA，且接著藉由qPCR評估5微升所得cDNA (跳躍正向引子5’-GGTGGGTGACCTTGAGGAT-3’ (SEQ ID NO: 1437)、跳躍探針5’-ATCATCAAGCAGAAGCAGTTGGCC-3’ (SEQ ID NO: 1438)及跳躍反向引子5’-GCCAAGTCATTTGCCACATCTA-3’ (SEQ ID NO: 1439))。使用跳躍之擴增子(IDT，外顯子51剪接至外顯子54)之雙股DNA片段驗證檢定並量化未知樣品中之拷貝數。所顯示的資料係顯示為外顯子53跳躍相對於陽性對照ASO之倍數變化。
SEQ ID NO: 平均倍數變化 SEQ ID NO: 平均倍數變化
413 1.005641 1109 0.7575
347 1.03 1110 0.405
828 1.0525 1111 0.891667
829 0.925 1112 0.7475
830 1.11875 1113 0.96625
831 0.985 1114 0.8
832 1.18 1115 0.78
836 0.65125 1116 0.90625
455 1.03 1117 1.106667
847 2.70375 1118 1.6675
848 2.49625 1119 1.4025
457 1.0575 1120 1.2325
456 0.935 1121 1.3
652 1.0075 522 1.5825
625 1.1825 523 1.205
624 1.245 524 1.035
626 0.975 525 0.8075
627 0.97 526 0.7825
592 0.8075 527 0.84
593 0.909167 528 1.2875
594 0.833333 529 2.4975
595 0.72625 530 2.85
596 0.619167 531 1.29
597 0.915833 532 0.815
612 0.871486 533 1.2
613 0.9175 534 0.5325
614 0.869167 537 1.67
453 0.8225 538 1.815
454 0.7375 1122 1.185
849 3.72 1123 1.18
809 1.201429 1124 0.9775
811 0.869965 1125 0.275
470 1.8175 1126 0.2825
540 6.1925 1127 0.22
762 0.944375 1128 3.62
850 0.914167 1129 2.9875
851 1.13 1130 3.1075
852 1.014167 1131 2.4025
853 1.055 1132 2.71
452 1.185 1133 2.3225
539 1.33 1134 1.9575
854 6.31625 1135 2.14
855 2.59875 1136 1.955
856 10.5225 1137 2.64
857 6.095 1138 1.7475
858 2.68125 1139 2.8475
859 1.084167 1140 2.5525
860 4.3075 1141 2.99
348 0.8025 1142 3.705
447 1.35 1143 3.465
808 0.56 1144 4.403333
810 1.0425 1145 3.9075
342 0.83504 1146 1.1025
833 0.815 1147 0.2425
467 0.565 1148 1.3275
469 1.095 1149 1.3625
349 1.1525 1150 1.8375
471 0.9725 1151 1.4425
478 0.345 1152 1.245
479 0.625 1153 1.355
480 0.3525 1154 1.245
841 3.0975 1155 1.3025
765 0.52125 1156 0.405
535 1.51 1157 0.4225
764 0.7125 1158 0.2675
761 0.6675 1159 1.79
536 1.6825 1160 0.9375
843 2.67 1161 1.22
602 0.205 1162 1.465
738 0.5875 1163 1.355
739 0.5325 1164 0.78
740 0.62 840 0.6125
741 0.765 1165 1.4975
861 0.9525 1166 1.435
862 0.6275 1167 1.44
863 0.4175 1168 1.7525
864 0.4 1169 6.7675
865 0.3425 1170 1.15
866 0.415 1171 1.38
867 0.35 1172 1.2125
868 0.845 1173 1.39
869 0.6575 1174 1.0675
870 0.4425 1175 0.99
603 0.3225 1176 1.5725
871 0.885 1177 1.5625
872 0.655 1178 1.4975
873 0.5625 1179 1.065
874 0.6875 1180 1.2525
875 0.71 1181 0.9625
876 0.5175 1182 1.3
877 0.725 1183 1.3275
878 0.65 1184 1.3525
879 0.3425 1185 1.15
880 0.6 1186 1.785
881 0.52 1187 2.0075
882 0.5625 1188 2.095
883 0.94 1189 1.9575
884 0.6725 1190 1.2375
604 0.4525 1191 1.445
885 0.8825 1192 1.605
886 0.6875 1193 1.4075
887 0.4325 1194 1.5925
888 0.775 1195 3.325
889 0.6775 1196 2.2175
890 0.51 1197 1.895
891 0.77 1198 2.0125
892 0.73 1199 2.335
893 0.4875 1200 1.935
894 0.7525 1201 1.73
895 0.5375 1202 2.0325
896 0.7675 1203 2.005
897 0.79 1204 1.2475
898 0.7975 1205 7.8675
605 0.33625 1206 4.1875
899 0.7175 1207 1.185
900 0.8775 1208 0.43
901 0.4025 1209 1.53
902 0.7825 1210 2.9425
903 1.01375 1211 3.165
904 0.885 1212 2.5875
759 0.9525 1213 1.975
760 0.61875 1214 1.165
763 0.485 1215 1.7725
766 0.4975 1216 2.295
611 0.88125 1217 1.9975
617 0.19 1218 2.02
905 0.82875 1219 1.055
906 0.7125 1220 1.6575
907 0.52 1221 0.6175
908 0.9275 1222 0.375
909 0.76 1223 0.235
910 0.55 1224 0.4875
911 0.695 1225 0.555
912 0.5125 1226 0.515
913 0.35 1227 0.19
914 0.3075 1228 0.395
915 0.49 1229 0.98
916 0.32 1230 0.105
917 0.2075 1231 0.345
918 0.23 1232 0.09
919 0.2225 1233 0.3375
920 0.205 1234 1.1925
921 0.125 1235 0.16
922 0.7775 1236 0.7625
923 0.6425 1237 0.1425
924 0.545 1238 0.92
606 0.305 1239 1.745
925 0.5725 1240 0.9675
926 0.4625 1241 1.265
927 0.4075 1242 0.88
928 0.6275 1243 0.4725
929 0.5025 1244 0.91
930 0.375 1245 1.9
931 0.5575 1246 1.0075
932 0.515 1247 0.7425
933 0.4375 1248 0.4675
934 0.26 1249 0.7475
935 0.54 1250 0.78
936 0.565 1251 0.285
937 0.1675 1252 0.17
938 0.2725 1253 1.56
939 0.215 1254 0.205
940 0.215 1255 1.715
941 0.1425 1256 1.495
942 0.7025 1257 1.285
943 0.645 1258 0.6525
607 0.715 1259 0.8275
944 0.8675 1260 1.7975
945 0.815 1261 0.505
946 0.8275 1262 1.3125
947 1.07125 1263 1.285
948 0.86 1264 1.58
949 0.605 1265 1.5075
950 1.015 1266 0.96
951 0.6625 1267 1.03
952 0.84 1268 1.225
953 0.7925 1269 1.545
954 1.09 1270 0.11
955 0.97 1271 0.2625
956 0.6275 1272 0.94
957 0.74 1273 0.4925
958 0.655 1274 0.3475
959 0.5975 1275 0.725
960 0.62 1276 0.69
961 0.9975 1277 0.7725
962 1.1525 1278 0.54
618 0.436876 1279 0.8875
963 0.831221 1280 0.7125
964 0.922637 1281 0.565
965 0.612314 1282 0.5
966 0.87697 1283 0.32
967 0.868321 1284 0.25
968 0.501353 1285 0.3425
969 0.672194 1286 0.3325
970 0.588231 1287 0.4925
971 0.438984 1288 0.405
972 0.35034 1289 0.4675
973 0.450383 1290 0.2775
974 0.436477 1291 0.2375
975 0.219905 1292 1.9175
976 0.209706 1293 0.8625
977 0.246885 1294 0.7575
978 0.200489 1295 0.61
979 0.158851 1296 0.865
980 0.996173 1297 1.1875
981 0.881826 1298 0.728943
982 0.580564 1299 0.888822
983 0.71 1300 1.024793
619 0.52 1301 1.0536
984 0.915 1302 0.859996
985 0.79 1303 1.035192
986 0.6325 1304 0.927026
987 0.825 1305 1.051433
988 0.72 1306 0.758934
989 0.4125 1307 0.750705
990 0.72 1308 1.132416
991 0.4875 1309 1.052031
992 0.475 1310 2.395
993 0.6425 1311 3.0225
994 0.5175 1312 3.0325
995 0.3725 1313 3.1275
996 0.53 1314 4.47
997 0.2625 1315 3.84
998 0.2725 1316 2.0725
999 0.195 1317 3.5575
1000 0.88375 1318 1.9175
1001 0.93875 1319 1.4225
1002 0.7325 1320 1.4475
1003 0.595 1321 1.1
620 0.49 1322 1.2275
1004 0.845 1323 1.24
1005 0.67 1324 2.1825
1006 0.4675 1325 1.0375
1007 0.84 1326 1.3075
1008 0.6075 1327 1.685
1009 0.915 1328 1.41
1010 0.595 1329 1.2275
1011 0.4625 1330 1.0875
1012 0.9625 1331 1.98
1013 0.9525 1332 1.11
1014 0.4025 1333 1.155
1015 0.7225 1334 1.4925
1016 0.395 1335 1.0575
1017 0.345 1336 1.09
1018 0.255 1337 1.7825
1019 0.91875 1338 1.5425
1020 0.93 1339 1.405
1021 1.09 1340 1.2325
1022 0.35 1341 1.17
718 0.7825 1342 1.97
462 0.46375 1343 1.6725
719 0.575 1344 1.74
720 0.575 1345 1.7575
1023 0.775 1346 5.8475
1024 0.6025 1347 5.61
1025 0.54 1348 3.9125
1026 0.435 1349 5.385
1027 0.425 1350 7.185
1028 0.2275 1351 5.5975
1029 0.59875 1352 3.9675
1030 0.615 1353 3.33
1031 0.285 1354 3.5725
1032 0.5575 1355 4.5675
1033 0.305 1356 4.76
1034 0.3025 1357 5.2375
1035 0.18 1358 4.4025
1036 0.9525 1359 4.9825
1037 0.83125 1360 4.315
1038 0.89125 1361 3.605
463 0.6825 1362 2.415
1039 0.4075 1363 1.15
1040 0.755 1364 3.5775
1041 0.8225 1365 1.8575
1042 0.61 1366 1.575
1043 0.645 1367 1.0875
1044 0.6175 1368 0.5125
1045 0.7925 1369 2.2025
1046 0.4725 1370 0.615
1047 0.4125 1371 0.8675
1048 0.65 1372 0.4925
1049 0.535 1373 1.1175
1050 0.345 1374 1.4825
1051 0.4675 1375 0.6
1052 0.36 1376 0.7825
1053 0.2425 1377 0.645
1054 0.1625 1378 0.4775
1055 0.8175 1379 0.735
1056 0.80625 1380 0.84
1057 0.6975 1381 0.565
461 0.8325 1382 0.9875
1058 0.445 1383 0.7225
1059 0.7875 1384 1.57
1060 0.8725 1385 0.8625
1061 0.5675 1386 0.475
1062 0.93625 1387 0.4175
1063 0.73 1388 0.6225
1064 0.505 1389 1.3175
1065 0.9625 1390 0.6825
1066 0.5775 1391 0.6575
1067 0.6025 1392 0.44
1068 0.815 1393 1.3525
1069 0.5625 1394 3.1325
1070 0.3825 1395 2.4425
1071 0.6975 1396 0.9275
1072 0.555 1397 1
1073 0.3375 1398 0.9825
1074 0.29 1399 0.82
1075 1.0875 1400 2.1775
1076 1.1825 1401 0.9975
1077 0.9725 1402 1.6025
1078 0.595 1403 0.5975
1079 0.78 1404 0.67
1080 0.5775 1405 3.4525
1081 0.4625 1406 3.375
1082 0.6175 1407 1.9775
1083 0.4625 1408 1.945
1084 0.615 1409 1.3375
1085 0.4225 1410 0.7025
1086 0.355 1411 3.1275
1087 0.38 1412 1.7875
1088 0.36 1413 3.4375
1089 0.315 1414 1.055
1090 0.275 1415 1.4225
1091 0.32 1416 1.195
1092 0.33 1417 0.9975
1093 0.425 1418 1.3175
1094 0.6375 1419 1.45
1095 0.655 1420 0.745
1096 0.3925 1421 1.0175
1097 0.37 1422 0.97
1098 0.38 1423 0.98
1099 0.32 1424 0.71
1100 0.295 1425 1
1101 0.3775 1426 1.2125
1102 0.3075 1427 0.715
1103 0.3125 1428 0.975
1104 0.3925 1429 0.96
1105 0.4525 1430 1.1375
1106 0.46 1431 0.8925
685 1.554167 1432 0.8775
694 1.595 1433 0.895
695 1.3725 1434 0.595
696 1.41125 1435 0.6875
1107 0.91125 1436 0.9475
1108 0.33
實例3
使用hDMD del52; mdx作為評估活體內外顯子53跳躍之模型系統(doi.org/10.1371/journal.pone.0193289及doi.org/10.1371/journal.pone.0244215)。活體內研究係根據自《指南(The Guide)》獲取之正確IACUC標準進行的，並經過了IACUC同行評審。連續4週，每週一次，經由側尾靜脈注射對五至八隻8-10週齡之小鼠靜脈內投與3.42 μmol/kg之ASO。在第4次給藥後一週收集組織，並根據需要，快速冷凍或固定在 4% PFA中。使用Covaris Cryoprep，藉由組織粉碎自冷凍樣品中萃取RNA，並使用Omni Bead Ruptor在Zymo RNA/DNA Shield緩衝液中進一步均質化。使用Cells-to-CT Bulk RT Reagents試劑盒(ThermoFisher)，使用150-200 ng RNA經由RT-PCR產生cDNA，且接著藉由ddPCR，使用引子集分析外顯子53跳躍情況，由此能夠對非跳躍外顯子53/54連接區、跳躍之外顯子51/54連接區、近似總轉錄本(外顯子46/47連接區)以及作為管家基因之UBC的拷貝數進行定量。外顯子53跳躍百分比係藉由以下方式計算：取得外顯子51/54連接區之拷貝數，將其除以46/47連接區之拷貝數，且接著乘以100。
隔膜 心臟 股四頭肌
研究 SEQ ID NO: 跳躍之外顯子53 % 標準差 跳躍之外顯子53 % 標準差 跳躍之外顯子53 % 標準差
1 媒劑 NA NA NA NA 0.42 0.13
1 401 NA NA NA NA 0.62 0.21
1 413 NA NA NA NA 0.8 0.2
1 347 NA NA NA NA 0.71 0.15
2 媒劑 1.07 0.27 0.8 0.04 0.39 0.08
2 455 2.27 0.77 1.53 0.17 0.88 0.12
2 847 3.71 2.04 1.73 0.26 1.02 0.22
2 848 1.61 0.45 1.39 0.33 0.87 0.23
2 828 1.45 0.12 1.15 0.1 0.84 0.22
2 829 1.53 0.63 1.43 0.22 1.12 0.3
2 830 1.23 0.07 1.26 0.11 0.95 0.16
2 831 1.73 0.25 1.57 0.22 1.05 0.26
2 832 1.51 0.65 1.41 0.13 1 0.14
2 836 2.24 0.68 1.22 0.31 0.86 0.08
3 媒劑 0.95 0.12 0.89 0.07 0.6 0.24
3 453 1.48 0.4 1.47 0.15 0.82 0.2
3 454 1.17 0.22 1.21 0.1 1.04 0.46
3 456 2.36 2.07 1.42 0.25 0.76 0.16
3 457 2.18 1.21 1.13 0.15 0.85 0.26
3 592 0.82 0.13 1.16 0.2 0.74 0.27
3 593 0.84 0.2 1.05 0.12 0.64 0.15
3 594 1.06 0.16 1.19 0.19 0.89 0.18
3 595 1.14 0.32 1.23 0.16 0.68 0.09
3 596 1.12 0.35 1.4 0.18 1.07 0.4
3 597 1.16 0.18 1.33 0.16 0.97 0.18
3 612 1.19 0.36 1.49 0.41 0.84 0.25
3 613 2.11 1.96 1.76 0.47 0.87 0.22
3 614 1.28 0.26 1.23 0.21 0.84 0.36
3 624 1.47 0.36 1.13 0.06 0.74 0.14
3 625 2.1 0.93 1.14 0.25 0.81 0.13
3 626 1.08 0.07 1.18 0.18 1.31 0.63
3 627 3.26 2.17 1.6 0.45 1 0.21
3 652 1.4 0.18 1.69 0.17 1.22 0.7
3 849 1.4 0.21 1.25 0.31 0.59 0.09
4 媒劑 NA NA NA NA 0.47 0.11
4 452 NA NA NA NA 0.63 0.23
4 470 NA NA NA NA 0.63 0.12
4 539 NA NA NA NA 1.2 1.07
4 540 NA NA NA NA 0.8 0.1
4 762 NA NA NA NA 0.87 0.07
4 850 NA NA NA NA 0.92 0.28
4 851 NA NA NA NA 0.76 0.13
4 852 NA NA NA NA 0.92 0.33
4 853 NA NA NA NA 0.99 0.41
4 858 NA NA NA NA 0.9 0.34
4 854 NA NA NA NA 0.72 0.2
4 855 NA NA NA NA 0.87 0.07
4 856 NA NA NA NA 0.86 0.19
4 857 NA NA NA NA 0.99 0.3
4 859 NA NA NA NA 1.3 0.91
4 860 NA NA NA NA 0.82 0.04
4 809 NA NA NA NA 0.87 0.27
4 811 NA NA NA NA 0.51 0.2
本揭露之範疇不受限於實例中所揭示之實施例，實例僅意欲作為個別態樣之單一說明，且任何等效物均在本揭露之範疇內。根據前面的描述，除本文所顯示及描述之內容之外的各種修改對於熟習此項技術者而言將變得顯而易見。此等修改意图在所附申請專利範圍之範疇内。
本文引用了各種參考文獻，諸如專利、專利申請案、及出版物，其揭示內容皆以引用之方式整體併入本文。
TW202448485A_113116532_SEQL.xml

Claims (26)

  1. 一種包含SEQ ID NO:1-1436中任一者之序列或由該序列組成的ASO，其含有至少一個修飾。
  2. 如請求項1之ASO，其中所有核苷酸均為RNA。
  3. 如請求項1或請求項2之ASO，其中糖部分之化學修飾為2'-MOE、2'-OMe、2'-F及/或LNA。
  4. 如請求項1或請求項2之ASO，其中該修飾為該ASO中所有核苷酸之糖部分的化學修飾。
  5. 如請求項1-4中任一項之ASO，其中該ASO中所有核苷酸之糖部分的化學修飾均為2'-MOE。
  6. 如請求項1-4中任一項之ASO，其中該糖部分之化學修飾為1、2、3或4個LNA，且其餘核苷酸為2'-MOE。
  7. 如請求項1-4及6中任一項之ASO，其中該ASO之兩個5'末端核苷酸位置及該ASO之兩個3'末端核苷酸位置的該糖部分之化學修飾皆為LNA，且其餘核苷酸為2'-MOE。
  8. 如請求項1或請求項2之ASO，其中該ASO中一或多個核苷酸之糖部分的化學修飾為嗎啉(PMO、PPMO、PMO-X)、肽衍生物(PNA)、硼簇修飾之PNA、基於吡咯啶之氧肽核酸(POPNA)、基於甘醇或甘油之核酸(GNA)、基於蘇糖之核酸(TNA)、基於無環蘇胺醇之核酸(aTNA)、基於陽離子N-嗎啉基之寡聚物(PMOPlus)、具有整合鹼基及主鏈之寡核苷酸(ONIB)、吡咯啶-醯胺寡核苷酸(POM)；或其衍生物。
  9. 如請求項1-8中任一項之ASO，其中該修飾為該ASO中1、2、3、4個或全部核苷酸之鹼基部分的化學修飾。
  10. 如請求項1-9中任一項之ASO，其中所有胞嘧啶鹼基均由5-甲基胞嘧啶替代。
  11. 如請求項1-10中任一項之ASO，其中所有胸腺嘧啶鹼基均由尿嘧啶替代。
  12. 如請求項1-11中任一項之ASO，其中該主鏈為完全硫代磷酸酯主鏈鍵聯。
  13. 如請求項1-12中任一項之ASO，其中該ASO在該ASO之5'末端、該ASO之3'末端或在該ASO之5'端及3'端皆包含羥基烷氧基。
  14. 如請求項1-12中任一項之ASO，其中該ASO在該ASO之5'末端、該ASO之3'末端或在該ASO之5'端及3'端皆包含經修飾之羥基烷氧基。
  15. 如請求項14之ASO，其中該羥基烷氧基包含以下或由以下組成：乙二醇單體、乙二醇寡聚物或乙二醇聚合物(亦稱為聚乙二醇，PEG)。
  16. 如請求項14或請求項15之ASO，其中該羥基烷氧基為TEG或HEG。
  17. 如請求項1-16中任一項之ASO，其中自該ASO之5'末端省去一個或兩個核苷酸，或其中自該ASO之3'末端省去一個或兩個核苷酸，或其中自該ASO之5'末端省去一個核苷酸且自該ASO之3'末端省去一個核苷酸。
  18. 如請求項17之ASO，其長度為16至30個核苷酸。
  19. 如請求項17或請求項18之ASO，其長度為16、17、18、19或20個核苷酸。
  20. 如請求項1-19中任一項之ASO，其長度為18個核苷酸。
  21. 如請求項1-5中任一項之ASO，其為完全2'-MOE RNA修飾的，其中所有胞嘧啶均由5-甲基胞嘧啶替代，且其中該主鏈為完全硫代磷酸酯主鏈。
  22. 如請求項1-7中任一項之ASO，其中所有胞嘧啶均由5-甲基胞嘧啶替代，該ASO之兩個5'末端核苷酸為LNA，該ASO之兩個3'末端核苷酸為LNA，其餘核苷酸為2'-MOE RNA修飾的，且其中該主鏈為完全硫代磷酸酯主鏈。
  23. 一種醫藥組成物，其包含如請求項1-22中任一項之ASO及醫藥學上可接受之載劑。
  24. 一種治療患有DMD之個體的方法，其包括向該個體投與如請求項1-22中任一項之ASO或如請求項23之醫藥組成物。
  25. 一種延遲個體之DMD發作的方法，其包括向該個體投與如請求項1-22中任一項之ASO或如請求項23之醫藥組成物。
  26. 一種誘導人類肌萎縮蛋白前驅mRNA之外顯子53跳躍的方法，其包括使人類肌萎縮蛋白前驅mRNA與如請求項1-22中任一項之ASO或如請求項23之醫藥組成物接觸。
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