TW200841886A - A new product for hair growth based on nitric oxide - Google Patents

Abstract

The invention refers to a product for hair growth, especially a product for healthy hair and prevents hair loss based on nitric oxide. The product for hair growth is made of nitrogen agent and acid agent. The nitrogen agent is sodium nitrite with concentration of about 0.02%-2.0% or concentrated vegetable extractive liquid containing nitrite abundantly. The acid agent is organic acid or inorganic acid. When the nitrogen agent is mixed with the acid agent, NO can be released controllably. Nitric Oxide dilate the capillary vessels and promotes blood circulation of head. Therefore, it can improve the blood supply and oxygen. In the meanwhile, it kill the human insects induced hair loss especially the chaff spore fungus.

Description

200841886 VIII. If there is a chemical formula in this case, please disclose the chemical formula showing the characteristics of the invention: 2N02" + H+- 2NO + H2〇9, invention description: [Technical field of invention] The present invention relates to a hair growth product and a health care product, In particular, it relates to a hair growth preparation based on nitric oxide for hair growth, hair loss prevention, hair growth and beauty. [Prior Art] With the improvement of human living standards, people pay more and more attention to their external image. However, because people's work and life rhythm is accelerating, brain power is thinking about the increase of load and other reasons, the phenomenon of hair loss is becoming more and more common. And hair loss hinders the appearance, which makes many people feel painful and even seriously affects some people. Normal life. Hair loss can be basically divided into temporary hair loss and permanent hair loss. Temporary hair loss is mostly caused by high fever, malnutrition, or some skin with inflammation, chronic wasting disease, and endocrine disorders, which reduce the blood supply of hair follicles or local neuromodulation disorders, resulting in temporary nutrition of hair follicles. Poor and undiscovered. Permanent hair loss can also be called male baldness, which is more common because of long-term damage to hair follicles. The root cause of hair loss is hair follicle damage, that is, hair follicle atrophy caused by hair loss to varying degrees. The most common seborrheic alopecia is caused by the decomposition of sebum by the head lice to block the hair follicle and the inability to deliver nutrients to the hair. According to the study, the normal human scalp blood flow is about 9 times that of other parts of the body, but in patients with alopecia, the scalp blood flow is 13.7: 53.7, and the difference is extremely significant. However, most of the products produced on the market today only stimulate the capillaries, increase the oxygen supply of the hair follicles, and the hair supply is long. However, the mechanism of the hair follicle itself has not been well improved, so it is easy to produce drugs. Since 1987, when it was discovered that vascular endothelial cells can synthesize endogenous nitric oxide, nitric oxide, a simple diatomic molecular free radical, has begun to show its infinite charm to the world, which was rated by the US magazine Science. 1992 "Molecule of the Year". After a lapse of five years, American scientists Ignarro, Murad, and Fuchgott won the 1998 Nobel Prize in Medicine for their outstanding work on "Nitric Oxide as a Signaling Signal for the Cardiovascular System." Their research reveals the signal transduction of gas molecules in living organisms, which has aroused the enthusiasm for nitric oxide in the medical, biological and chemical worlds.

Nitric oxide is a vasodilating component that allows blood vessels to relax, thereby increasing blood flow and promoting blood circulation, which is a function of boosting blood circulation and oxygen supply. Nitric oxide is a very small lipophilic molecule that rapidly diffuses through the biofilm barrier by paracrine action, reaches adjacent target cells, and is linked to the ferrous hemoglobin portion of the guanylate cyclase in the cell, causing The enzyme is initiated to increase the conversion of guanosine triphosphate to c-guanosine monophosphate (cGMP) by 50-200 fold, resulting in an increase in intracellular cGMP. cGMP then initiates a GMP-dependent protein kinase or a calcium channel that acts directly on the cell membrane, causing calcium ion efflux or intracellular free calcium binding, thereby allowing smooth muscle cell relaxation and vasodilation, in the process, cGMP 4 200841886 plays the role of the second messenger. At the same time, GMP also inhibits platelet aggregation and adhesion of blood/Jx® to the vascular endothelium. Nitric oxide synthesis is involved in the non-specific defense of several pathogens. Macrophages, etc., can synthesize and release nitric oxide at the initiation or under certain pathological conditions, and cause cytotoxicity, inhibiting TCA, electron transport and cellular DNA synthesis in target cell mitochondria, producing bacteria, fungi and tumor cells. Its killing effect promotes acute inflammatory reaction of tissues, participates in tissue damage and wound healing, thereby causing tissue damage and/or cell necrosis, killing bacteria, viruses, parasites and tumor cells. Nitric oxide is a vasodilating component that allows blood vessels to relax, thereby increasing blood flow and promoting blood circulation. SP has the function of increasing local blood circulation and oxygen supply, and at the same time, because of nitric oxide against bacteria, fungi, and parasitic Insects and tumor cells have a killing effect. The head lice, which is the culprit of hair loss, is a tiny animal that is parasitic on the scalp. They are parasitic in human hair follicles, feed on sebum, secrete lipolytic enzymes, invade sebaceous glands, and block hair follicles. The most common one is Pityrosporum, one of the fungi, which causes one of the causes of JI-induced alopecia. At present, there are no reports of nitric oxide-based hair growth products. SUMMARY OF THE INVENTION The object of the present invention is to provide a kind of nitric oxide to promote the relaxation of blood vessels in the brain, thereby increasing the blood supply and oxygen supply of the hair follicle, and simultaneously cleaning and repairing the hair follicle, thoroughly improving the hair follicle itself and the surrounding environment, and enhancing The overall growth of the head hair, and does not produce hair growth, hair loss prevention, hair growth and cosmetic hair growth preparations. The present invention is achieved by the following technical solutions: The present invention is a health care product and a special hair care product based on nitric oxide capable of improving the quality of hair follicles, and is composed of a nitrogen agent and an acid agent. Among them: the nitrogen agent is made up of nitrite or a plant extract containing nitrite; the acid agent is made of an organic acid or an inorganic acid. When the nitrogen agent and the acid agent are combined, the active ingredient, nitric oxide, can be released locally and in a controlled manner. The two-part type hair growth preparation of the invention and the manufacturing process thereof: The nitrogen agent of the invention: The nitrogen agent used in the hair growth product of the invention is nitrite or concentrated nitrite-rich plant extract with corresponding The matrix excipients are mixed, emulsified, sterilized, and filled into hair growth products of different dosage forms and different functions. Among them, the nitrite is preferably sodium nitrite. The acid agent of the present invention is an organic acid used in the hair growth product, such as: citric acid monohydrate, maleic acid, etc. or inorganic acid, such as boric acid, etc., mixed with the corresponding matrix auxiliary materials, and stirred. Sterilize and fill the hair growth preparations with different dosage forms and different functions. The matrix adjuvants used in the above nitrogen and acid agents are substantially the same as those used in existing hair growth products. For example, stearic acid, eucalyptus oil, dimethyl oxime or the like is used as a softening agent, and glycerin, hyaluronic acid, wheat germ oil, propylene glycol or the like is used as a humectant, and cetyl alcohol, stearyl alcohol, and monostearic acid are used. Glycerin, disodium edetate, octadecyloxytrimethyl sane (and) stearyl alcohol, aluminum starch octyl octyl acrylate, etc. as emulsifier, using hydroxyethyl cellulose, white oil, Xanthan gum, hydrogenated castor oil, octyldodecanol myristate, etc. as a thickener, using bromopol, methylparaben, propylparaben, etc. as a preservative, using green tea flavor, etc. For the fragrance, VE acetate is used as an antioxidant; and an extract such as American ginseng, safflower or peppermint is used as a traditional Chinese medicine extract. The amount of each component in Kiwi is also generally the same as that of existing hair care products. The dosage of the main agent and the substrate of the product of the invention is in the range of percentage by weight: 1. Nitrogen agent (1) active ingredient nitrite (sodium nitrite or plant concentrate containing nitrite) 〇·〇1%~1 ·〇 % 5 200841886 . (2) Hair care product base: 1~90% (3) The balance is water; 2. Acid agent (1) One or more of the active ingredients ascorbic acid, maleic acid, a 7jc citric acid, boric acid ·〇1%~2·0 % (2) Hair care product base: 1-90% (3) The balance is water. It can also contain other commonly used hair care ingredients, such as: neutralizers, surfactants, waxes, sunscreens, vitamins, anti-wrinkle active ingredients, etc. Dosage: The hair products are divided into two parts, nitrogen and acid. ^ Clean the hair on the scalp, dry the scalp of the hair loss, evenly spread the nitrogen of the bean size to the scalp of the hair loss, then evenly spread the sour bean size to the scalp of the hair loss, while using the finger to do a light massage in the hair loss area In order to increase the penetration of the liquid agent, promote absorption, and facilitate the effect. Precautions for use: When using the hair care product, contact the acid agent and the nitrogen agent, and try to ensure that the nitrogen agent is applied to the skin before the acid is applied. This is because: After the acid agent and the nitrogen agent are in contact, the nitric oxide can be released locally to avoid bacterial infection, and the anti-inflammatory, skin local immunity and hair loss effect can be achieved, and the local blood vessels can be relaxed, the hair follicle can be cleared, and the hair follicle can be promoted. Hair growth. 2. Because the acid agent is close to the outside, the acid agent has the reducing ability, which reduces the possibility of newly generated nitric oxide being oxidized. * Storage: Store in a cool, dry place. [Embodiment] The embodiments are merely preferred embodiments of the present invention, and the scope of the present invention is not limited thereto. In general, according to the scope of the invention patent application, the equal variation and modification, that is, the nitric oxide production technology is dissolved in various hair growth products, and the different composition formulas and different dosage forms of the hair growth products are still the patents of the present invention. Covered by the scope. The listed examples are all one of the best compositions of the product of the present invention, and the dosage is recorded by weight percentage, wherein the active ingredient of the nitrogen agent can be extracted from plants such as spinach extract containing nitrite in addition to sodium nitrite. liquid. Solution 1: Applicable to beauty, health -7 y acid] m ingredient name (%) dosage (%) ingredient name (%) dosage (%) sodium nitrite 0.04 ascorbic acid 0.04 I EDTA ^ 0.2 salicylic acid 0.5 200841886 glycerol 3.0 Propylene glycol 0.1 hydroxyethyl cellulose 0.1 hydroxyethyl cellulose 0.1 Fragrance _ 0.1 Fragrance 0.1 Deionized water balance Deionized water balance Option 2: For people who have a large amount of hair loss due to work and life stress, nervousness: NS !1 Acid 3 m Ingredients Soap (%) Dosage (%) Ingredient name % (%) Dosage (柘) Sodium nitrite 0.2 Ascorbic acid 0.4 Menthol 0.2 Olive oil 5.0 Capsicum 0.2 Glycyrrhizic acid 0.1 Liquid paraffin 10.0 Ethanol 50.0 Ni Potassium methyl ester 0.1 Nipagin methyl ester 0.1 Fragrance 0.1 Fragrance 0.1 Deionized water balance Deionized water balance scheme III·Applicable to slightly bald people: N agent acid ingredient name (%) Dosage (%) Ingredient name (%) Dosage (%) Sodium nitrite 0.4 Ascorbic acid 0.8 Biotin 0.005 Boric acid 5.0 D-Panthenol 0.2 Vitamin E Nicotinate 0.01 Camphor 0.1 Concentrated Glycerin 50.0 Nipagin C 0.1 propyl paraben 0.1 Mint essence 0.1 Mint essence 0.1 Deionized water balance 1 Deionized water balance Option 4: Suitable for spastic alopecia (heavier in anti-inflammatory): N剤 | Acid ingredient name (%) Dosage (%) Ingredient name (%) Dosage (%) Sodium nitrite 0.6 Ascorbic acid 1 200841886 Long press 0.005 L Cysteine 0.01 Solid paraffin 3.0 Allantoin 0.03 Parabens 0.1 Salicyl sulphate C 0.1 Mint Flavor 0.1 Nipa Gold Butadiene 0.1 Deionized Water Balance Mint Flavor 0.1 Deionized Water Tengli Scheme 5: Suitable for people with severe hair loss (commonly known as the Mediterranean): NS 3 acid] Name of ingredients (%) Usage (% Ingredient name (%) Dosage (%) Sodium nitrite 1 Ascorbic acid 1.5 Grape seed oil 3.0 Maleic acid 0.6 Ethanol 2.0 Liquid paraffin 10.0 Nipagin ethyl ester 0.1 Nipagin ethyl ester 0.1 Fragrance 0.1 Fragrance 0.1 Deionized water balance Deionized Water Balance Scheme 6: Applicable to all bald people: a Acid】 Shaved ingredient name (%) Dosage (%) Ingredient name (%) Dosage (%) Sodium nitrite 2 Ascorbic acid 1.2 Placenta hydrosol 15.0 Isopropanol 21.7 Ethanol 22.0 Hydroxyethyl cellulose 0.4 Nipagin ethyl ester 0.1 Fatty alcohol 50.0 Fragrance 0.1 Nipagin ethyl ester 0.1 Hydroxyethyl cellulose 0.4 Fragrance 0.1 Deionized water Tengli deionized water Balance 7: Apply to lipid raft ΝΙ « _ II acid! _ ingredient name (%) dosage (%) 1 ingredient name (%) dosage (%) sodium nitrite 1.8 I ascorbic acid 2.0 200841886 Γ 0.15 VB6 0.15 adenosine Triphosphate 0.01 Salicylic acid 0.2 Inositol 0.1 Menthol 0.1 Nipagin ethyl ester 0.1 Nipagin ethyl ester 0.1 Fragrance 0.1 Fragrance 0.1 1 Deionized water Residual deionized water balance Nitrogen and acid listed in the above examples The preparation process of the agent is as follows: in the order from top to bottom listed in the table, the components are sequentially added to the water, mixed and stirred to completely dissolve, and then allowed to stand to make the solution clear, and the mixture is sterilized under aseptic conditions. . BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 shows a hair growth product comprising two systems: a nitrogen agent containing nitrite as a raw material 2 and an acid agent 1 using vitamin C, an organic acid or a mineral acid as a raw material, when the two are used in combination Hair tissue at the head of the hair loss 8 can produce an appropriate amount of N04 [Main component symbol description] 1 represents an acid agent containing vitamin C, organic acid or inorganic acid as raw material; 2 represents a nitrogen agent containing nitrite; 3 represents Hair tissue at the head of the hair loss; 4 represents nitric oxide

Claims (1)

200841886 X. Patent application scope: 1 · New hair growth products based on nitric oxide, characterized in that the hair growth product contains a nitrogen agent and an acid agent, and when the nitrogen agent and the acid agent are combined, the nitric oxide is locally released. 2. The novel hair growth product based on nitric oxide according to claim 1, wherein the nitrogen agent is a nitrite or a nitrite-rich plant extract; and the acid agent is an organic acid or a mineral acid. 3. The nitric oxide-based novel hair-developing article according to claim 1, wherein the nitrogen agent is sodium nitrite; and the acid agent is one or more of ascorbic acid, citric acid monohydrate, maleic acid, and boric acid. 4. The novel nitric oxide-based hair growth product according to claim 2, wherein the nitrite-rich plant is spinach 'aubergine. 5. The novel hair growth product based on nitric oxide according to claim 1, which further comprises a germinal product base. 6. The novel hair growth product based on nitric oxide according to claim 4, wherein the hair growth product base is one or more of a preservative, a fragrance, an antioxidant, a neutralizing agent, a surfactant, and a Chinese herbal extract. . 7. The novel hair growth product based on nitric oxide according to claim 5, wherein the base of the hair growth product is stearic acid, eucalyptus oil, dimethyl decane, glycerin, hyaluronic acid, wheat germ oil, propylene glycol, Cetyl alcohol, octadecyl alcohol, glyceryl monostearate, disodium edetate, octadecyloxytrimethyl decane and stearyl alcohol, aluminum starch octyl succinate, hydroxyethyl cellulose , white oil, xanthan gum, hydrogenated castor oil, octyldodecanol myristate, bromopol, methylparaben, propylparaben, green tea flavor, Polygonum, ginseng, angelica 'red flower, One or more of extracts such as astragalus and ginkgo. 8 · A novel nitric oxide-based hair growth product according to the scope of application of the patent, wherein the weight percentage of each component is ·· a·nitrogen agent (1) active ingredient··nitrite 〇·〇2% ~2.0% (2) Hair care product base: 1~90% (3) The balance is water; b. Acid agent (1) Active ingredient · · Ascorbic acid, maleic acid 'one water citric acid, boric acid one or more 0.5~ 4% (2) Hair to be used as a base: 1 to 90% (3) The balance is water. 9. The novel hair growth product based on nitric oxide according to the scope of claim 1 is applied by first applying a nitrogen agent and then applying an acid agent. 0 10 200841886 V. Abstract: The present invention relates to a hair growth product and a health care product, in particular It relates to a hair growth preparation based on nitric oxide for hair growth, hair loss prevention, hair growth and beauty. The hair growth product consists of a nitrogen agent and an acid agent, the nitrogen agent is sodium nitrite (55 sodium nitrate concentration is 〇.〇2%-2.0%) or the concentrated nitrite-rich plant extract, the acid agent is organic The acid or inorganic acid, when combined with the nitrogen agent and the acid agent, provides a locally controllable release of the active ingredient nitric oxide. Nitric oxide relaxes the capillaries of the brain, promotes blood circulation, increases local blood supply and oxygen supply, and kills fungi such as pityrosporum, which is one of the causes of seborrheic alopecia, which is one of the causes of seborrheic alopecia. In order to achieve the desired healthy hair, anti-hair loss, hair loss, hair growth effect. Sixth, English invention summary: The invention refers to a product for hair growth, especially a product for healthy hair and prevents hair loss based on nitric oxide. The product for hair growth is made of nitrogen agent and acid agent. The nitrogen agent is sodium nitrite with concentration of about 0.02 The acid agent is organic acid or inorgemic acid. When the nitrogen agent is mixed with the acid agent, NO can be released controllably. Nitric Oxide dilate the capillary vessels and promotes Blood circulation of head., it can improve the blood supply and oxygen. In the cotton, it kill the human insects induced hair loss especially the chaff spore fungus. Figure (1). (2) The symbolic symbols of the representative figures are as follows: 1 represents an acid agent containing vitamin C, an organic acid or a mineral acid as a raw material; 2 represents a nitrogen agent containing nitrite; 3 represents a skin tissue of the head of the hair loss; 4 represents nitric oxide 200841886 VIII. If there is a chemical formula in this case, please disclose the chemical formula showing the characteristics of the invention: 2N02" + H+- 2NO + H2〇9, invention description: [Technical field of invention] The invention relates to a hair growth Supplies and health products, in particular, a nitric oxide-based hair growth preparation for hair growth, hair loss prevention, hair growth and beauty. [Prior Art] With the improvement of human living standards, people pay more and more attention to their external image. However, because people's work and life rhythm is accelerating, brain power is thinking about the increase of load and other reasons, the phenomenon of hair loss is becoming more and more common. And hair loss hinders the appearance, which makes many people feel painful and even seriously affects some people. Normal life. Hair loss can be basically divided into temporary hair loss and permanent hair loss. Temporary hair loss is mostly caused by high fever, malnutrition, or some skin with inflammation, chronic wasting disease, and endocrine disorders, which reduce the blood supply of hair follicles or local neuromodulation disorders, resulting in temporary nutrition of hair follicles. Poor and undiscovered. Permanent hair loss can also be called male baldness, which is more common because of long-term damage to hair follicles. The root cause of hair loss is hair follicle damage, that is, hair follicle atrophy caused by hair loss to varying degrees. The most common seborrheic alopecia is caused by the decomposition of sebum by the head lice to block the hair follicle and the inability to deliver nutrients to the hair. According to the study, the normal human scalp blood flow is about 9 times that of other parts of the body, but in patients with alopecia, the scalp blood flow is 13.7: 53.7, and the difference is extremely significant. However, most of the products produced on the market today only stimulate the capillaries, increase the oxygen supply of the hair follicles, and the hair supply is long. However, the mechanism of the hair follicle itself has not been well improved, so it is easy to produce drugs. Since 1987, when it was discovered that vascular endothelial cells can synthesize endogenous nitric oxide, nitric oxide, a simple diatomic molecular free radical, has begun to show its infinite charm to the world, which was rated by the US magazine Science. 1992 "Molecule of the Year". After a lapse of five years, American scientists Ignarro, Murad, and Fuchgott won the 1998 Nobel Prize in Medicine for their outstanding work on "Nitric Oxide as a Signaling Signal for the Cardiovascular System." Their research reveals the signal transduction of gas molecules in living organisms, which has aroused the enthusiasm for nitric oxide in the medical, biological and chemical worlds. Nitric oxide is a vasodilating component that allows blood vessels to relax, thereby increasing blood flow and promoting blood circulation, which is a function of boosting blood circulation and oxygen supply. Nitric oxide is a very small lipophilic molecule that rapidly diffuses through the biofilm barrier by paracrine action, reaches adjacent target cells, and is linked to the ferrous hemoglobin portion of the guanylate cyclase in the cell, causing The enzyme is initiated to increase the conversion of guanosine triphosphate to c-guanosine monophosphate (cGMP) by 50-200 fold, resulting in an increase in intracellular cGMP. cGMP in turn initiates a GMP-dependent protein kinase or a calcium channel that acts directly on the cell membrane, causing calcium ion efflux or intracellular free calcium binding, thereby allowing smooth muscle cell relaxation and vasodilation, in the process, cGMP 4