JP7591881B2 - Skin preparations - Google Patents

Description

Article 30, paragraph 2 of the Patent Act applied. Promotional materials for "propo (Warming Serum)" were distributed at the 2019 FIA Leaders Symposium on June 20, 2019.

The present invention relates to an external skin preparation that can maintain or improve the effects of exercise.

As the world becomes more convenient, people move their bodies less in their daily lives, and many people feel that they are not getting enough exercise. For this reason, more and more people are exercising or playing sports on a daily basis. There are various reasons for exercising, including physical effects such as maintaining or improving muscle strength and endurance, improving cardiopulmonary function, maintaining health by preventing lifestyle-related diseases, preventing decline in physical function due to aging, relieving pain in the lower back or knees, promoting blood circulation, and losing weight, as well as mental effects such as changing one's mood or relieving stress, preventing dementia, and improving vague symptoms. Exercising can range from very high-intensity exercise aimed at improving muscle strength, endurance, cardiopulmonary function, etc., to less intense exercise aimed at maintaining health and relieving stress.

When exercising at a very high intensity to improve muscle strength, endurance, cardiopulmonary function, etc., it is recommended that after exercise, active rest be performed, such as gradually reducing the amount of exercise, stretching, or cooling down by cooling the muscles with ice or topical agents (icing) and massaging them to promote the repair of muscle tissue damaged by the load (Non-Patent Documents 1 and 2). For this reason, many cooling-down devices and topical skin agents are commercially available.

"How to quickly cure and prevent muscle pain" Kanagawa Prefectural Sports Center Newsletter "Sports Center Newsletter No. 57" Warmup & Cooldown Special Edition for Selected Athletics (Published by Tokyo Metropolitan Sports Foundation, Sports Medicine and Science Support Project for Improving Competitiveness)

On the other hand, until now, no advice has been given on care during or after exercise for exercise that is not very intense. However, due to recent changes in living and working environments, an increasing number of people are engaging in light exercise for the purposes of maintaining health and relieving stress. The inventors have found that, because these light exercisers do not exercise frequently, they tend to prefer a long-lasting pleasant feeling after exercise. In other words, they have found new needs, such as the desire to feel like they have exercised well with light exercise, and the desire to improve the efficiency of the exercise effect or shorten the time required for exercise. Specifically, these are requests for a long-lasting feeling of warmth and sweating, so that they can feel like they have exercised well for a long time, and for warming down.

However, although there are many topical skin preparations on the market that can cool down muscles, no topical skin preparations are known that can keep the body warm after exercise from cooling down or that can maintain the pleasant sensations, such as the warmth and refreshing feeling, that come with exercise.

Therefore, the objective of the present invention is to provide an external skin preparation that can sustain or enhance the effects obtained through exercise.

The inventors conducted extensive research to solve the above problems and discovered that by applying a composition containing a component that promotes fat burning and a component that promotes sweating to the skin during exercise, the effects of exercise, such as increased body temperature and sweating, can be effectively sustained.

The present invention has been completed based on the above findings, and provides the following external skin preparation.
[1] A skin topical preparation comprising (A) a component that promotes fat burning, and (B) a component that promotes sweating.
[2] The topical skin preparation according to [1], wherein the component (A) is at least one selected from the group consisting of (A1) a component having the effect of promoting the decomposition of triglycerides, (A2) a component having the effect of promoting the uptake of fatty acids produced by the decomposition of triglycerides, and (A3) a component having the effect of promoting the combustion of fatty acids in mitochondria.
[3] The external skin preparation according to [2], wherein the component (A1) is an extract of a plant of the Asteraceae family, the component (A2) is L-carnitine, and the component (A3) is an extract of a plant of the Brassicaceae family.
[4] The skin external preparation according to any one of [1] to [3], comprising Tambourissa trichophylla extract and/or Asteraceae plant extract as component (B).
[5] The topical skin preparation according to any one of [1] to [4], wherein the total content of the component (A) is, in terms of the plant extract, 0.0002 to 10% by weight, based on the total amount of the topical skin preparation, calculated on a dry weight basis.
[6] The topical skin preparation according to any one of [1] to [5], wherein the total content of the component (B) is, in terms of the plant extract, 0.0001 to 10% by weight based on the total amount of the topical skin preparation, calculated on a dry weight basis.
[7] The external skin preparation according to any one of [1] to [6], further comprising a fragrance.
[8] The external skin preparation according to any one of [1] to [7], which is used for sustaining or improving the effect of exercise.
[9] The external skin preparation according to [8], wherein the sustained or improved exercise effect is the maintenance or improvement of skin temperature, sweating, blood flow, and/or a sense of refreshment.
[10] The external skin preparation according to any one of [1] to [9], which is applied to the skin during or after exercise.
[11] A method for maintaining or improving the effects of exercise, comprising the step of applying to the skin during exercise an external skin preparation comprising (A) a component that promotes fat burning and (B) a component that promotes sweating.

When the skin preparation of the present invention is applied to the skin during exercise, the effect of exercise is sustained or improved. Therefore, even light exercise can give a sense of having exercised well (sense of effectiveness) and a sense of satisfaction. Specifically, the body temperature (particularly skin or body surface temperature) increased by exercise, the increase in sweating due to exercise, the increase in blood flow due to exercise, the refreshing state due to exercise, etc. are sustained or increased.
Although body temperature (particularly, skin or body surface temperature) usually rises due to exercise, when exercise is stopped, the rise in body temperature slows down or even falls due to evaporation of sweat, but when the skin preparation of the present invention is used, the body temperature (particularly, skin or body surface temperature) that has risen due to exercise is maintained, even though sweating continues, and in some cases, body temperature may even rise further. In addition, by using the skin preparation of the present invention, sweating after exercise is sustained and the amount of sweating increases.
In addition, the pleasant sensations or bodily sensations after exercise, such as a warm feeling, sweating, increased blood flow, and a feeling of refreshment, are also sustained or enhanced.

Although the skin topical preparation of the present invention is effective when used before exercise, using it during or after exercise more effectively maintains or improves the exercise effect, exercise sensation, and exercise bodily sensation.

This figure shows the rate of change in neck surface temperature 10 and 20 minutes after exercise when the skin topicals of Example 1, Example 2, and Comparative Example 2 were applied to the neck, and when nothing was applied (Comparative Example 1). This figure shows the rate of change in surface temperature of the back of the hand 10 minutes and 20 minutes after exercise when the skin topical agents of Example 1, Example 2, and Comparative Example 2 were applied to the back of the hand, and when nothing was applied (Comparative Example 1). This figure shows the rate of change in palm surface temperature 10 and 20 minutes after exercise when the skin topicals of Example 1, Example 2, and Comparative Example 2 were applied to the palm, and when nothing was applied (Comparative Example 1).

The topical skin preparation of the present invention is a preparation that contains (A) a component that promotes fat burning and (B) a component that promotes sweating.

(A) Components that promote fat burning Examples of components that promote fat burning include (A1) components having the effect of promoting the decomposition of triglycerides, (A2) components having the effect of promoting the uptake of fatty acids produced by the decomposition of triglycerides, and (A3) components having the effect of promoting the combustion of fatty acids in mitochondria.
The skin topical preparation of the present invention may contain one or more components that promote fat burning. It may also contain one or more of the components (A1), (A2), and (A3). It is particularly preferred that the skin topical preparation contains the components (A1), (A2), and (A3).

(A1) Components that have the effect of promoting the decomposition of triglycerides The fat stored as lipid droplets in fat cells is neutral fat, i.e., triglycerides. The neutral fats of animals, including humans, are a mixture of triglycerides with various fatty acid compositions.
In fat cells, when catecholamine hormones such as adrenaline and noradrenaline bind to receptors on the cell surface, hormone-sensitive lipase and perilipin are activated by phosphorylation. Lipase is an enzyme that breaks down triglycerides into glycerol and fatty acids. Perilipin is a protein that is bound to the surface of fat droplets, and under normal circumstances prevents hormone-sensitive lipase from acting on fat droplets, but when it is phosphorylated by catecholamine hormone stimulation, it promotes the action of hormone-sensitive lipase. A protein called CGI-58 is present on the surface of fat droplets, interacting with perilipin, and when perilipin is phosphorylated by catecholamine hormone stimulation, CGI-58 is released from the fat droplets and activates fat cell-specific triglyceride lipase. Fat cell-specific triglyceride lipase acts particularly strongly on triglycerides compared to hormone-sensitive lipase. Furthermore, the complete decomposition of triglycerides into three fatty acids and glycerol requires the stepwise action of monoacylglycerol lipase.

The component having the effect of promoting the decomposition of triglycerides may promote any stage up to the decomposition of triglycerides into three fatty acids and glycerol.
Examples of such ingredients include extracts of Asteraceae plants (particularly, Chrysantherm plants such as Chrysantherm indicum (golden chamomile) and Stevia plants such as Stevia), neem leaf extract, lemongrass extract, Angelica keiskei extract, brown algae extracts (kelp extract, hijiki extract, fucus vesiculosus extract, wakame extract, etc.), green algae extracts (ulva extract, green laver extract, etc.), red algae extracts (agarwood extract, Asakusa-nori extract, Susabinori extract, etc.), jujube (Zatsume) fruit extract, Eucommia ulmoides (Eucommia ulmoides) extract, Chlorella extract, Euglena gracilis (also called Euglena or Euglena) extract, Horn poppy leaf extract, Globularia cordifolia callus culture extract, Zingiber officinale extract, Bupleurum falcatum root extract, coenzyme A, caffeine, and the like.
Examples of mixtures of ingredients having the above-mentioned effects include a mixture of Euglena gracilis extract, caffeine, and Horn Poppy leaf extract (Phytosonic (trade name); Sedama), a mixture of Globularia cordifolia callus culture extract, caffeine, and Chinese ginger extract (Inteslim (trade name); Sedama), and a mixture of Bupleurum saiko root extract, caffeine, and coenzyme A (Lipocare (trade name); Sedama).
Among them, in terms of their strong effect of promoting the decomposition of triglycerides, extracts of plants of the Asteraceae family (especially Chrysantherm indicum and Stevia) and a mixture of Euglena gracilis extract, caffeine and Corn Poppy leaf extract (e.g., Phytosonic (Sederma)) are preferred, and extracts of plants of the Asteraceae family (especially Chrysantherm indicum) are more preferred. An example of a product containing Chrysantherm indicum extract is Lanacris (Lucas Meyer).
The component having the effect of promoting the decomposition of triglycerides may be used alone or in combination of two or more.

When the skin topical preparation of the present invention contains the (A1) component (particularly an extract of a plant of the Asteraceae family, particularly a plant of the genus Chrysanthellum and/or a plant of the genus Stevisa, particularly Chrysanthellum indicum and/or Stevia), the content of the component is preferably 0.000005% by weight or more, more preferably 0.00001% by weight or more, and even more preferably 0.00005% by weight or more, based on the total amount of the skin topical preparation. Also, the content is preferably 1% by weight or less, more preferably 0.5% by weight or less, and even more preferably 0.1% by weight or less. For plant extracts, this content is a value calculated from the weight converted to dry weight. If it is within this range, it can act together with the (B) component to sufficiently maintain or improve the exercise effect.

(A2) Components with Fatty Acid Uptake Promoting Effects Fatty acids produced by the decomposition of triglycerides are bound to albumin and transported in the blood, and are taken up into the cells of various tissues of the body. The fatty acids taken up into the cells are oxidized and decomposed in the mitochondria to extract energy. Among fatty acids, medium-chain fatty acids can pass through the mitochondrial membrane without the involvement of other components, but long-chain fatty acids cannot pass through the mitochondrial membrane alone.
Ingredients that have the effect of promoting the uptake of fatty acids include ingredients that have the effect of promoting the uptake of fatty acids into cells, and ingredients that have the effect of transporting fatty acids that have been taken up into cells into the mitochondrial membrane or the effect of permeabilizing the mitochondrial membrane.

Examples of ingredients that have the effect of promoting the uptake of fatty acids into cells include Bacillus/soybean fermentation extract. Examples of ingredients that have the effect of transporting fatty acids into mitochondria or permeabilizing the mitochondrial membrane include L-carnitine, its salts (tartrates, fumarates, hydrochlorides, etc.), or its derivatives (esters with fatty acids such as acetate and palmitic acid, etc.), astaxanthin, and Cistanche Tubulosa (Cistanche Tubulosa) extract. Among these, L-carnitine is preferred.
The component having the effect of promoting the uptake of fatty acids may be used alone or in combination of two or more.

When the topical skin preparation of the present invention contains component (A2) (particularly L-carnitine), its content is preferably 0.0001% by weight or more, more preferably 0.001% by weight or more, and even more preferably 0.005% by weight or more, based on the total amount of the topical skin preparation. Also, it is preferably 10% by weight or less, more preferably 5% by weight or less, and even more preferably 1% by weight or less. In the case of plant extracts, this content is a value calculated from the weight converted to dry weight. If it is within this range, it can act together with component (B) to sufficiently maintain or improve the exercise effect.

(A3) Component having the effect of promoting fatty acid combustion in mitochondria As described above, fatty acids taken up into cells undergo β-oxidation in mitochondria to become acetyl CoA, which is further decomposed to carbon dioxide in the citric acid cycle, and energy is extracted via the electron transport system. In the present invention, the component promoting fatty acid combustion in mitochondria may be one that promotes any stage of the reaction in the β-oxidation of fatty acids, the citric acid cycle, or the electron transport system.
Such ingredients include extracts (particularly root or leaf extracts) of Brassicaceae plants (particularly, plants of the genus Columbine such as Lepidium meyenii (Maca)), tea leaf extracts, ginseng extracts, Angelica keiskei extracts, malic acid, ketooctadecadienoic acid, Bacillus/soybean fermentation extracts, etc. Among these, extracts (particularly root or leaf extracts) of Brassicaceae plants (particularly, plants of the genus Columbine such as Lepidium meyenii (Maca)) are preferred.
Products containing Lepidium meyenii (Maca) extract include Macaline (ExpanScience).
The components that promote the combustion of fatty acids in mitochondria can be used alone or in combination of two or more.

When the skin topical preparation of the present invention contains the (A3) component (particularly an extract of a Brassicaceae plant such as Lepidium meyenii), the content of the component is preferably 0.00001% by weight or more, more preferably 0.0001% by weight or more, and even more preferably 0.0005% by weight or more, based on the total amount of the skin topical preparation. Also, the content is preferably 10% by weight or less, more preferably 1% by weight or less, and even more preferably 0.1% by weight or less. For plant extracts, this content is a value calculated from the weight converted to dry weight. If it is within this range, it can act together with the (B) component to sufficiently maintain or improve the exercise effect.

The total content of component (A) in the topical skin preparation of the present invention is preferably 0.0002% by weight or more, more preferably 0.002% by weight or more, and even more preferably 0.006% by weight or more, based on the total amount of the topical skin preparation. It can also be 0.01% by weight or more. It is also preferably 10% by weight or less, more preferably 5% by weight or less, and even more preferably 1% by weight or less. It can also be 0.3% by weight or less. For plant extracts, this content is a value calculated from the weight converted to dry weight. If it is within this range, it can act together with component (B) to sufficiently maintain or improve the exercise effect.

(B) Components that promote perspiration Examples of components that promote perspiration include components that have both perspiration-inducing and moisturizing effects, such as extracts of Tambourissa trichophylla (particularly leaves), extracts of plants of the Asteraceae family (particularly butterbur plants (particularly leaves, stems, and roots), and plants of the Deer family (particularly flowers) such as chamomile (also called chamomile, German chamomile, or Roman chamomile)). Other examples include extracts of Araceae (particularly roots), extracts of Capsicum anguicum (particularly fruits), and extracts of ginger (particularly rhizomes).
The components that promote sweating may be used alone or in combination of two or more.

Among these, ingredients having both sweat-inducing and moisturizing effects are preferred, and extracts of Tambourissa trichophylla and Asteraceae plants (particularly, butterbur and other butterbur plants, and Deer Daisy and other chamomile plants) are more preferred.
Tambourissa trichophylla is a tree that grows in Madagascar and the Comoros Islands, where it is called Amborasa or Ambora and has been used for wound healing, etc. An example of a product containing Tambourissa trichophylla leaf extract is Ambora Extract (Bayer Sante Familliale).
Products containing butterbur extract include Butterbur Extract-WSPC, Butterbur Extract-PC, and Butterbur Extract-LC (Oryza Oil & Fat Chemical Co., Ltd.), and NBA Butter Bur Extract (Arch Personal Care Co., Ltd.).
Examples of chamomile extracts include chamomile extract, chamomile extract BG-J, chamomile extract LA (Maruzen Pharmaceutical Co., Ltd., Iwase Cosfa Co., Ltd.), chamomile extract LS, oil-soluble chamomile extract M, and oil-soluble chamomile extract P (Koei Kogyo Co., Ltd.). In addition, chamomile extracts are commercially available under names such as chamomile extract, chamomile water, Roman chamomile oil, and Roman chamomile flower oil, and can be used.

The total content of component (B) in the topical skin preparation of the present invention is preferably 0.0001% by weight or more, more preferably 0.001% by weight or more, and even more preferably 0.005% by weight or more, based on the total amount of the topical skin preparation. It can also be 0.01% by weight or more. It is also preferably 10% by weight or less, more preferably 5% by weight or less, and even more preferably 3% by weight or less. It can also be 1% by weight or less. For plant extracts, this content is a value calculated from the weight converted to dry weight. If it is within this range, it can act together with component (A) to sufficiently maintain or improve the exercise effect.

When the skin external preparation of the present invention contains the extract of Tambourissa trichophylla, its content is preferably 0.00001% by weight or more, more preferably 0.0001% by weight or more, based on the total amount of the skin external preparation, calculated as dry weight.Moreover, it is preferably 10% by weight or less, more preferably 5% by weight or less, and even more preferably 1% by weight or less.Within this range, it can act together with the (A) component to sufficiently maintain or improve the exercise effect.
When the skin external preparation of the present invention contains the extract of butterbur or other butterbur plants, its content is preferably 0.0001% by weight or more, more preferably 0.001% by weight or more, based on the total amount of the skin external preparation, calculated as dry weight. Also, it is preferably 10% by weight or less, more preferably 5% by weight or less. Within this range, it can act together with the (A) component to sufficiently maintain or improve the exercise effect.
When the skin external preparation of the present invention contains the extract of the plant of the genus Deer, such as Chamomile, its content is preferably 0.0001% by weight or more, more preferably 0.001% by weight or more, based on the total amount of the skin external preparation, calculated as dry weight.Moreover, it is preferably 10% by weight or less, more preferably 5% by weight or less.Within this range, it can act together with the (A) component to sufficiently maintain or improve the exercise effect.

The ratio of the total content of the (B) component to 1 part by weight of the total content of the (A) component is preferably 0.0001 parts by weight or more, more preferably 0.001 parts by weight or more, and even more preferably 0.01 parts by weight or more. It can also be 0.1 parts by weight or more. It is also preferably 1000 parts by weight or less, more preferably 100 parts by weight or less, and even more preferably 10 parts by weight or less. It can also be 1 part by weight or less. For plant extracts, this content is a value calculated from the weight converted to dry weight. Within this range, the exercise effect can be sufficiently maintained or improved.

In the present invention, unless otherwise specified, the plant extract may be an extract of any part of the plant, such as leaves, stems, flowers, fruits, roots, or rhizomes, or may be an extract of the whole plant.

Solvents used for extraction include hydrophilic or polar solvents such as water; aqueous solutions of inorganic salts such as sodium chloride, potassium chloride, magnesium chloride, and ammonium carbonate; buffer solutions such as phosphate buffer, acetate buffer, Tris-HCl buffer, carbonate buffer, and borate buffer; aqueous solutions of inorganic acids such as hydrochloric acid, carbonic acid, sulfuric acid, nitric acid, and phosphoric acid; aqueous solutions of organic acids such as acetic acid, citric acid, lactic acid, succinic acid, ascorbic acid, fumaric acid, and malic acid; aqueous solutions of surfactants such as saponin and lecithin; lower alcohols such as methanol, ethanol, propanol, and butanol; and ketones such as acetone and ethyl methyl ketone.
Other examples include hydrophobic solvents such as hydrocarbons such as propane, butane, hexane, and cyclohexane; glycerin; ethers such as diethyl ether; glycols such as propylene glycol; halogenated hydrocarbons such as dichloromethane, 1,1,1,2-tetrafluoroethane, and 1,1,2-trichloroethene; and acetates such as ethyl acetate and methyl acetate.
The solvents may be used alone or in combination of two or more.

The extraction temperature can be appropriately set, for example, at 4 to 130° C., and preferably at 20 to 100° C. The extraction can also be performed at room temperature.
The extract may be used in a liquid state (including fluid, viscous, etc.) or may be dried and used in a solid state (including semi-solid, gel, etc.), for example in powder form.

(C) Warming component The skin topical preparation of the present invention may further contain (C) a warming component.
Examples of warming sensation components include compounds having a vanillyl group, such as vanillyl ethers represented by vanillyl butyl ether, vanillyl amide nonanoate, and vanillyl amides represented by capsaicin. From the viewpoint of effectively exerting the effects of the present invention, vanillyl ethers are preferred, and vanillyl butyl ether is more preferred.
The warming component acts together with the components (A) and (B) of the present invention to significantly or synergistically sustain or improve the exercise effect.

(D) Fragrances The skin topical preparation of the present invention may further contain fragrances, which may mask the odor of sweat and the like and may further effectively sustain or improve the effects of exercise.
As the fragrance, essential oils are preferable, and examples thereof include bergamot oil, peppermint oil, lavender oil, eucalyptus oil, rosemary oil, rosehip oil, peppermint oil, spearmint oil, vetiver oil, lithodia cubeba oil, lemon oil, sandalwood oil, nutmeg oil, cinnamon oil, hyssop oil, caraway oil, orange oil, cade oil, grapefruit oil, lime oil, salvia oil, thyme oil, clove oil, aloe oil, jasmine oil, neroli oil, rose oil, camphor oil, geranium oil, sandalwood oil, ylang-ylang oil, medicinal herb, and oleaginous herb. Examples of oils that may be used include lyssa oil, basil oil, patchouli oil, juniper oil, juniper berry oil, sage oil, black pepper oil, marjoram oil, amyris oil, mugwort oil, wormwood oil, angelica oil, ginger oil, allspice oil, cascarilla oil, calamus oil, clary sage oil, celery oil, tea tree oil, carrot oil, patchouli oil, vetiver oil, hops oil, mastic oil, myrrh oil, labdanum oil, turmeric oil, origanum oil, galangal oil, citronella oil, bay oil, yarrow oil, pimento berry oil, and lovage oil.
Among these, bergamot oil and eucalyptus oil are preferred, and bergamot oil is more preferred. Limonene, linalool, and linalyl acetate, which are the main components of bergamot oil, can also be used.
Also preferred are terpenes such as menthol, camphor, borneol, geraniol, cineol, anethole, limonene and eugenol (which may be in any of the d-, l- or dl-forms).

When the topical skin preparation of the present invention contains a fragrance, the content of the fragrance is preferably 0.0001% by weight or more, more preferably 0.001% by weight or more, and even more preferably 0.01% by weight or more, based on the total amount of the topical skin preparation. Also, the content is preferably 5% by weight or less, more preferably 1% by weight or less, and even more preferably 0.5% by weight or less. Within this range, a sufficient masking effect is obtained, and depending on the fragrance, the exercise effect is maintained or improved.

Other Components The topical skin preparation of the present invention can be prepared as a cosmetic or quasi-drug topical skin preparation by mixing the above-mentioned components (A), (B), and optionally (C) with a base or carrier used in cosmetics or quasi-drugs, and, if necessary, with additives and other physiologically active or pharmacologically active components.

Examples of additives include surfactants, thickeners, preservatives, pH adjusters, stabilizers or chelating agents, ultraviolet absorbing agents or ultraviolet scattering agents, irritation reducing agents, and colorants.
The additives may be used alone or in combination of two or more.
Moreover, additives can be used within a range that does not impair the effects of the present invention.

Surfactants include sorbitan fatty acid esters such as sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, diglycerol sorbitan penta-2-ethylhexyl acid, and diglycerol sorbitan tetra-2-ethylhexyl acid, glycerin fatty acids such as glycerin monostearate and glycerin monostearate malate, polyglycerin fatty acids such as polyglyceryl monoisostearate and polyglyceryl diisostearate, propylene glycol fatty acid esters such as propylene glycol monostearate, and polyoxyethylene hydrogenated castor oil (polyoxyethylene hydrogenated castor oil). Examples of such derivatives include hydrogenated castor oil derivatives such as polyoxyethylene hydrogenated castor oil 40, polyoxyethylene hydrogenated castor oil 60, and polyoxyethylene hydrogenated castor oil 80; polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene (20) sorbitan monolaurate (polysorbate 20), polyoxyethylene (20) sorbitan monostearate (polysorbate 60), and polyoxyethylene (20) sorbitan monooleate (polysorbate 80); polyoxyethylene monococoate glyceryl, glycerin alkyl ether, alkyl glucoside, polyoxyethylene cetyl ether (cetomacrogol), stearylamine, and oleylamine.

Thickening agents include thickening polysaccharides (guar gum, locust bean gum, carrageenan, xanthan gum, dextran, etc.), cellulose-based thickening agents (methylcellulose, ethylcellulose, carboxymethylcellulose, carboxyethylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, etc.), alginic acid, its salts and its derivatives (alginic acid, sodium alginate, propylene glycol alginate, etc.), vinyl-based thickening agents (polyvinyl alcohol, polyvinylpyrrolidone, polyvinyl methyl ether, carboxyvinyl polymer, acrylic acid/alkyl methacrylate copolymer, sodium polyacrylate, etc.), bentonite, dextrin fatty acid ester, pectin, etc.

Preservatives include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl parahydroxybenzoate, isopropyl parahydroxybenzoate, butyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate, benzyl parahydroxybenzoate, methyl parahydroxybenzoate, phenoxyethanol, and BHT.

Examples of pH adjusters include inorganic acids (hydrochloric acid, sulfuric acid, phosphoric acid, polyphosphoric acid, boric acid, etc.), organic acids (lactic acid, acetic acid, citric acid, tartaric acid, malic acid, succinic acid, sodium succinate, oxalic acid, gluconic acid, fumaric acid, propionic acid, acetic acid, aspartic acid, epsilon-aminocaproic acid, glutamic acid, aminoethylsulfonic acid, etc.), gluconolactone, ammonium acetate, inorganic bases (sodium bicarbonate, sodium carbonate, potassium hydroxide, sodium hydroxide, calcium hydroxide, magnesium hydroxide, etc.), and organic bases (monoethanolamine, triethanolamine, diisopropanolamine, triisopropanolamine, lysine, etc.).

Examples of stabilizers or chelating agents include sodium edetate, tetrasodium edetate, and tetrasodium edetate tetrahydrate.

Examples of ultraviolet absorbing agents or ultraviolet scattering agents include 2-ethylhexyl paramethoxycinnamate, 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoic acid hexyl ester, 2,4,6-tris[4-(2-ethylhexyloxycarbonyl)anilino)-1,3,5-triazine, t-butylmethoxydibenzoylmethane, ethylhexyl dibenzylidene dioxoimidazolidine propylonate, ethylhexyl triazoline, paraaminobenzoic acid and its derivatives, octyl paradimethylaminobenzoate, ethylene glycol salicylate, dihydroxybenzophenone, titanium oxide, and zinc oxide.

Irritation reducing agents include licorice extract and sodium alginate.

Coloring agents include those listed in the Legal Dye Handbook (edited by the Japan Cosmetic Industry Association (2004)).

Other physiologically or pharmacologically active ingredients include, for example, moisturizing ingredients, vitamins, peptides or derivatives thereof, blood circulation promoting ingredients, cell activating ingredients, anti-aging ingredients, whitening ingredients, amino acids, proteins, plant extracts (excluding component (A) and component (B)), etc.
The other physiologically or pharmacologically active ingredients may be used alone or in combination of two or more.
In addition, other physiologically or pharmacologically active ingredients can be used within the scope that does not impair the effects of the present invention.

Moisturizing ingredients include polyhydric alcohols such as glycerin, dipropylene glycol, 1,3-butylene glycol, propylene glycol, polyethylene glycol, diglycerin, pentanediol, hexanediol, and octanediol; sugars such as trehalose, xylitol, and sorbitol; polymeric compounds such as sodium hyaluronate, heparinoids, sodium chondroitin sulfate, keratin, chitin, and chitosan; lipids such as ceramide, cholesterol, and phospholipids; and plant extracts such as witch hazel extract and tea extract.

Vitamins include vitamin E such as dl-α-tocopherol, dl-α-tocopherol acetate, dl-α-tocopherol succinate, and dl-α-tocopherol calcium succinate, ubiquinone derivatives and their pharma- ceutical or physiologically acceptable salts, riboflavin, flavin mononucleotide, flavin adenine dinucleotide, riboflavin butyrate, riboflavin tetrabutyrate, riboflavin 5'-phosphate sodium, riboflavin tetranicotinate, dl-α-tocopherol nicotinate, and benzyl nicotinate. , methyl nicotinate, β-butoxyethyl nicotinate, 1-(4-methylphenyl)ethyl nicotinate, ascorbigen-A, ascorbyl stearate, ascorbyl palmitate, L-ascorbyl dipalmitate, methylhesperidin, ergocalciferol, cholecalciferol, phylloquinone, farnoquinone, gamma-oryzanol, dibenzoyl thiamine, dibenzoyl thiamine hydrochloride, thiamine hydrochloride, thiamine cetyl hydrochloride, thiamine thiocyanate, thiamine lauryl hydrochloride, thiamine nitrate, thiamine mono ... Thiamine phosphate, thiamine lysine salt, thiamine triphosphate, thiamine monophosphate phosphate, thiamine monophosphate, thiamine diphosphate, thiamine diphosphate hydrochloride, thiamine triphosphate, thiamine triphosphate monophosphate, pyridoxine hydrochloride, pyridoxine acetate, pyridoxal hydrochloride, pyridoxal 5'-phosphate, pyridoxamine hydrochloride, cyanocobalamin, hydroxocobalamin, deoxyadenosylcobalamin, folic acid, pteroylglutamic acid, nicotinic acid, nicotinamide, pantothenic acid, pantothenic acid, Examples of such pantothenic acids include calcium pantothenate, pantothenyl alcohol (panthenol), D-pantethein, D-pantethine, coenzyme A, pantothenyl ethyl ether, etc., biotin, bioticin, ascorbic acid, sodium ascorbate, dehydroascorbic acid, sodium ascorbyl phosphate, magnesium ascorbyl phosphate, carnitine, ferulic acid, α-lipoic acid, orotic acid, hesperidin, γ-oryzanol, orotic acid, rutin, eriocitrin, and pharma- ceutical or physiologically acceptable salts thereof.

Examples of peptides or derivatives thereof include keratin decomposition peptides, hydrolyzed keratin, collagen, gelatin, elastin, elastin decomposition peptides, collagen decomposition peptides, hydrolyzed collagen, and hydrolyzed silk.

Examples of blood circulation-promoting ingredients include extracts of ginseng, angelica, arnica, ginkgo, Japanese oak, Dutch oak, carrot, gentian, burdock, rice, hawthorn, shiitake mushroom, European hawthorn, European juniper, Cnidium rhizome, Swertia britannica, thyme, clove, Chinese ginger, Angelica acutiloba, Prunus persica, spruce, carrot, garlic, butcher's broom, grape, peony, horse chestnut, melissa, yuzu, coix seed, rosemary, rose hip, peach, apricot, walnut, and corn, as well as glucosyl hesperidin (citrus peel extract) and cepharanthin (Tamasakisazurafuji root extract).
The blood circulation-promoting component acts together with the components (A) and (B) of the present invention to significantly or synergistically sustain or improve the effect of exercise.

Cell activation ingredients include amino acids such as gamma-aminobutyric acid, gamma-amino-beta-hydroxybutyric acid, and epsilon-aminocaproic acid, vitamins such as retinol, thiamine, riboflavin, pyridoxine hydrochloride, pantothenic acids, and biotin, alpha-hydroxy acids such as glycolic acid and lactic acid, tannins, flavonoids, saponin, allantoin, photosensitizer No. 301, placenta extract, hinokitiol, cepharanthin, and kiwi seed extract.

Anti-aging ingredients include pangamic acid, kinetin, ursolic acid, turmeric extract, sphingosine derivatives, silicon, silicic acid, N-methyl-L-serine, and mevalonolactone.

Skin-whitening ingredients include tocopherol, ascorbic acid, tranexamic acid, arbutin, 4-alkylresorcinol, 4-methoxysalicylic acid, hydroquinone, kojic acid, their salts or derivatives, and plant extracts such as placenta extract, Phellodendron bark extract, Saxifraga extract, aloe extract, and Matecha extract.

Base or Carrier The base or carrier includes an oily base and an aqueous base.
Examples of oily bases include hydrocarbons such as liquid paraffin, petrolatum, gelling hydrocarbons (such as Plastibase), ozokerite, α-olefin oligomers, and light liquid paraffin; methyl polysiloxane, crosslinked methyl polysiloxane, highly polymerized methyl polysiloxane, cyclic silicone, alkyl-modified silicone, crosslinked alkyl-modified silicone, amino-modified silicone, polyether-modified silicone, polyglycerin-modified silicone, crosslinked polyether-modified silicone, crosslinked alkyl polyether-modified silicone, silicone/alkyl chain co-modified polyether-modified silicone, silicone/alkyl chain co-modified polyglycerin-modified silicone. silicone oils such as polyether-modified branched silicone, polyglycerin-modified branched silicone, acrylic silicone, phenyl-modified silicone, and silicone resin; higher alcohols such as cetanol, cetostearyl alcohol, stearyl alcohol, and behenyl alcohol; sterols such as cholesterol, phytosterol, and phytosteryl hydroxystearate; vegetable fats such as shea butter, carnauba wax, and candelilla wax; animal fats and oils such as lanolin, orange roughy oil, squalane, horse oil, spermaceti, and beeswax; ethyl cellulose, hydroxypropyl cellulose, hydroxyethyl cellulose natural polymer derivatives such as cellulose, hydroxypropyl methylcellulose, cationic guar gum, and acetylated hyaluronic acid; synthetic polymers such as polyvinylpyrrolidone, carboxyvinyl polymers, and alkyl acrylate/methacrylate copolymers; natural polymers such as carrageenan, alginic acid, cellulose, xanthan gum, guar gum, quince seed, dextran, gellan gum, and hyaluronic acid; isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, cetyl palmitate, isononyl isononanoate, pentaerythritol tetra 2-ethylhexanoate, and tri(caprylic/capric)glycerol. Examples of the fatty acid esters include lyceryl; polysaccharides such as dextrin and maltodextrin; and glycol ethers such as ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, diethylene glycol monobutyl ether, propylene glycol monoethyl ether, propylene glycol monopropyl ether, dipropylene glycol monoethyl ether, and dipropylene glycol monopropyl ether.
In addition to water and buffer solutions, aqueous bases include lower alcohols such as ethanol and isopropanol; and polyhydric alcohols such as polyethylene glycol, propylene glycol, 1,3-butylene glycol, glycerin, isoprene glycol, diglycerin, and dipropylene glycol.
The substrate or carrier may be used alone or in combination of two or more.

The formulation of the topical skin preparation of the present invention is not particularly limited, and examples thereof include liquids, suspensions, emulsions, creams, ointments, gels, liniments, lotions, foams, sprays, aerosols, powders, poultices, sheets of nonwoven fabric or the like impregnated with a medicinal liquid, etc. Among these, lotions, gels, emulsions, creams, sprays, and aerosols are preferred because they are easy to spread on the skin and have a good feel when used.
In the case of an emulsified formulation such as an emulsion, cream, or emulsion ointment, it may be either an oil-in-water type or a water-in-oil type, but the oil-in-water type is preferred in terms of better usability.

The skin topical preparation of the present invention can be applied to the skin during exercise and used to maintain or improve the effects obtained by exercise. Specifically, it can be used to maintain or increase the temperature of the skin or body (particularly, the temperature of the skin or body increased by exercise), to maintain or increase sweating (particularly, sweating increased by exercise), to maintain or increase blood flow (particularly, blood flow increased by exercise), and to maintain or promote a refreshing state (particularly, a refreshing state increased by exercise).
By using the skin external preparation of the present invention, the exercise effect is sustained or increased even in light exercise, so that the user can feel as if they have exercised properly (feeling of effectiveness). Therefore, the sustained or improved exercise effect can also be considered as the sustained or improved feeling of exercise.
Furthermore, when the exercise effect is sustained, the pleasant sensation or feeling caused by exercise is sustained, so the sustained or improved exercise effect can be regarded as the sustained or improved sensation or feeling of exercise. Specifically, the skin topical preparation of the present invention can be used to maintain or improve a sense of warmth (particularly, a sense of warmth increased by exercise), to maintain or improve a sense of sweating (particularly, a sense of sweating increased by exercise), to maintain or improve a sense of increased blood flow (particularly, a sense of increased blood flow increased by exercise), and to maintain or improve a sense of refreshment (particularly, a sense of refreshment increased by exercise).

Method of Use The skin external preparation of the present invention may be applied to the skin during exercise. It may be applied before exercise, during exercise, or after exercise, but it is preferable to apply it during exercise or after exercise, and more preferable to apply it after exercise. Before exercise, it can be within 10 minutes, especially within 5 minutes, especially within 1 minute before exercise. After exercise, it can be within 30 minutes, especially within 10 minutes, especially within 5 minutes, especially within 1 minute after exercise, especially within 30 seconds after exercise. After exercise, it may be applied as it is, or it may be applied after wiping off sweat, or it may be applied after washing off sweat with a shower or the like. When applying, it may be applied so as to be lightly blended, but it is preferable to apply it while massaging.
In addition, the composition may be applied once or multiple times before, during, and after exercise.

The exercise time suitable for use of the topical skin preparation of the present invention is not particularly limited. For example, the exercise time may be 1 minute to 12 hours, 3 minutes to 3 hours, 5 minutes to 2 hours, 10 minutes to 1 hour, 20 to 30 minutes, or 10 to 15 minutes.

The application site of the skin topical agent of the present invention is not particularly limited. Examples include the skin of the neck, arms, hands, trunk (abdomen, waist, back, chest, buttocks), legs, face, etc. Among them, application to the neck, arms, hands, trunk (abdomen, waist, back, chest, buttocks), legs, especially the arms, hands, trunk (abdomen, waist, back, chest, buttocks), and legs will have a large effect of sustaining or improving the exercise effect.
The amount of the skin preparation of the present invention to be used is not particularly limited, and may be an amount sufficient for absorption by the skin, such as about 0.001 to 0.01 g per 1 ^cm2 of skin.
The method of application to the skin varies depending on the formulation, and can be by painting, spraying, pasting, etc.

Method for maintaining or improving the effects of exercise The present invention encompasses a method for maintaining or improving the effects of exercise, comprising the step of applying to the skin, during exercise, a preparation (the topical skin preparation of the present invention) containing (A) a component that promotes fat burning and (B) a component that promotes sweating.
This method of maintaining or improving the effect of exercise may be a method of maintaining or increasing skin or body temperature (particularly, skin or body temperature increased by exercise), a method of maintaining or increasing sweating (particularly, increased sweating by exercise), a method of maintaining or increasing blood flow (particularly, increased blood flow by exercise), a method of maintaining or improving a state of exhilaration, a method of maintaining or improving the sensation of exercise, a method of maintaining or increasing the sensation or feeling of exercise, a method of maintaining or improving the sensation of warmth (particularly, the sensation of warmth increased by exercise), a method of maintaining or improving the sensation of sweating (particularly, the sensation of sweating increased by exercise), a method of maintaining or improving the sensation of increased blood flow (particularly the sensation of increased blood flow increased by exercise), or a method of maintaining or improving a feeling of exhilaration.

The methods of the present invention do not include medical methods, i.e., they do not include treatment methods or preventive methods as medical methods.
The type and amount of each component, dosage, method of use, application site, etc. in the method of the present invention are as explained for the topical skin preparation of the present invention.

The present invention will be described in more detail below with reference to examples, but the present invention is not limited to these.

(1) Evaluation of body surface temperature In a constant temperature environment (22°C ± 1°C), four subjects (four women) in their 20s and 30s pedaled an exercise bike (registered trademark, Yamato Human Co., Ltd., YAB-881N) for 15 minutes under constant load conditions (load 3), and immediately after the exercise on the exercise bike, the temperature of the skin on the body surface (front of the neck, palm, back of the hand) was measured using a thermograph (NEC Avio Infrared Technologies Co., Ltd., TVS-500EX). Immediately after wiping off sweat, each composition listed in Table 1 was applied to the neck, palm, and back of the hand at about 2 mg/ ^cm2 , and then the subjects were allowed to rest in a seated position. 10 minutes and 20 minutes after the end of the exercise, the body surface temperature of the composition application site was measured, and the rate of change in body surface temperature after exercise was calculated according to the following formula (1).

Body surface temperature change rate after exercise = [(body surface temperature 10 or 20 minutes after exercise - body surface temperature immediately after exercise) / body surface temperature immediately after exercise] x 100 (%)
・・・・・・Formula (1)

In Comparative Example 1, no composition was applied, and only the body surface temperature was measured.

実施例１、実施例２、比較例２の組成物は、その他成分として、さらに、メチルポリシロキサン、アクリル酸・メタクリル酸アルキル共重合体、高重合メチルポリシロキサン、２－エチルヘキサン酸セチル、ヒアルロン酸Ｎａ、エタノール、ニコチン酸アミド、キレート剤、香料を含む。これらの成分は、実施例１、実施例２、比較例２の各組成物に同濃度が配合されている。

The compositions of Example 1, Example 2, and Comparative Example 2 further contain, as other components, methylpolysiloxane, acrylic acid/alkyl methacrylate copolymer, highly polymerized methylpolysiloxane, 2-ethylhexanoate cetyl, sodium hyaluronate, ethanol, nicotinamide, a chelating agent, and a fragrance. These components are blended in the same concentrations in each of the compositions of Example 1, Example 2, and Comparative Example 2.

The average values of the body surface temperature change rates are shown in Table 2 and Figures 1 to 3.

By applying the skin preparations of Examples 1 and 2 after exercise, the body surface temperature was generally higher 10 or 20 minutes after exercise than immediately after exercise. On the other hand, when the skin preparation of Comparative Example 2, which does not contain either component (A) or component (B) of the present invention, was applied after exercise, the body surface temperature was lower 10 or 20 minutes after exercise than immediately after exercise. Therefore, it can be seen that the incorporation of components (A) and (B) of the present invention increases the body surface temperature after exercise.
In addition, the skin topical preparation of Example 2, which contains the components (A) and (B) of the present invention but does not contain vanillyl butyl, and the skin topical preparation of Example 1, which contains the components (A) and (B) of the present invention and vanillyl butyl, showed similar body surface temperature change rates. Considering that the skin topical preparation of Comparative Example 2, which contains vanillyl butyl but does not contain the components (A) and (B) of the present invention, showed a negative body temperature change rate when applied, it can be seen that vanillyl butyl and the components (A) and (B) of the present invention act synergistically to increase the body surface temperature after exercise.

(2) Sensory Test In the test "(1) Evaluation of Body Surface Temperature", the sensations felt by four subjects were evaluated by a sensory test. The sensory test was conducted using a visual analog scale (VAS) method for (1) refreshing sensation, (2) warm sensation (warm sensation), and (3) sweating sensation. For each question item, the VAS used a 10 cm line with the left end (0) representing "no sensation at all" being the worst state and the right end (100) representing "very strong sensation" being the best state, and each subject answered the magnitude of the sensation they felt by drawing a diagonal line on the 10 cm line. The sensory test was conducted without subjects being able to identify the contents of the formulation.

It was confirmed that the VAS scores for all items generally showed a downward trend over time.
According to the following formula (2), the decrease in VAS score after 10 or 20 minutes of exercise in the case of no application (Comparative Example 1) was used as the standard, and the rate of inhibition of the decrease in VAS score when each topical composition was applied was calculated, and this was taken as the inhibition rate of decrease in feeling of efficacy.

Inhibition rate of decrease in efficacy (%)
= {1 - (VAS value immediately after exercise for each example - VAS value 10 or 20 minutes after exercise for each example) / (VAS value immediately after exercise for Comparative Example 1 - VAS value 10 or 20 minutes after exercise for Comparative Example 1)} x 100
・・・・・・・・・(2)

The results are shown in Table 3.

It was confirmed that the application of the skin topicals of Examples 1 and 2 after exercise had a high inhibitory effect on the decline in the sense of effectiveness in all of the categories of "refreshing sensation,""warmsensation," and "sweating sensation" 10 and 20 minutes after exercise. Therefore, it can be seen that the blending of components (A) and (B) of the present invention enhances the sustained effect of the sense of effectiveness of exercise.
In addition, when the skin preparation of Comparative Example 2, which contains vanillyl butyl but does not contain the components (A) and (B) of the present invention, was applied, the inhibition rate of the decrease in the sense of sweating was very low at 3.9%, and the skin preparation of Example 2, which contains the components (A) and (B) of the present invention but does not contain vanillyl butyl, was 31.5%, whereas the skin preparation of Example 1, which contains the components (A) and (B) of the present invention and vanillyl butyl, was very high at 45.5%. It can be seen that vanillyl butyl and the components (A) and (B) of the present invention act synergistically to maintain the feeling of effect after exercise.

(3) Evaluation of body surface temperature and sweat amount Five subjects (three men and two women) in their 20s to 40s drank a protein-containing beverage and then pedaled an exercise bike (registered trademark, Yamato Human Co., Ltd., YAB-881N) for 20 minutes under constant load conditions (load 3). The temperature of the skin on the body surface (front of the neck, palm, back of the hand) was measured using a thermograph (NEC Avio Infrared Technologies Co., Ltd., TVS-500EX) immediately after the exercise bike, 10 minutes later, and 20 minutes later. In addition, the amount of sweat on the forearm for 10 minutes after the exercise bike and the amount of sweat for 10 minutes from 10 minutes to 20 minutes later were measured using an SKN-2000 PERSPIRATION METER (Nishizawa Electric Meters Mfg. Co., Ltd.).
Five subjects performed the above exercise and measurements twice, one of which was performed without application of any topical skin preparation, and the other was performed with approximately 2 mg/ ^cm2 of the gel-type topical skin preparation of Example 1 applied to each area immediately after exercise.
The protein-containing beverage consisted of a protein powder containing black ginger extract and chili pepper extract, mixed with 150 mL of water at a protein content of 7 g per session.

The results are shown in Table 4.
The numerical values in the body surface temperature column in Table 4 are the average values of the rate of change in body temperature after exercise calculated using the above formula (1).
The average value of the accumulated amount of sweat for 10 minutes was calculated as the amount of sweat, and the amount of sweat for 10 minutes immediately after exercise without application of the skin preparation was used as the standard to calculate the ratio of the amount of sweat according to the following formula (3). The ratio of the amount of sweat is also shown in Table 4.

Sweat rate ratio = sweat rate for 10 minutes from immediately after exercise to 10 minutes after exercise or sweat rate for 10 minutes from 10 minutes to 20 minutes after exercise) / sweat rate for 10 minutes from immediately after exercise to 10 minutes after exercise without application
・・・・・・・・・(3)

By applying the skin preparation of the present invention after exercise, the increase rate of body surface temperature is larger than that of not applying it.In addition, when not applying it, body surface temperature may decrease after exercise, but by applying the skin preparation of the present invention immediately after exercise, even if body surface temperature decreases once after exercise, it will then rise again quickly.The increase in body surface temperature by using the skin preparation is particularly noticeable in women.
In addition, it was confirmed that the amount of sweat produced was clearly increased by the use of the topical skin preparation, and that this increasing trend was maintained even after some time had passed after exercise, with the total amount of sweat produced being significantly greater than when no topical preparation was applied.

In addition, when each subject was interviewed about the sensation of using the topical skin preparation, the following comments were obtained: "Areas that tend to get cold without application did not get cold after application.", "After application of the topical skin preparation, the palms and neck gradually warmed up a while, but without application, this warm sensation was not felt.", and "Without application, the sweaty body felt cold 20 minutes after exercise, but even 20 minutes after application of the topical skin preparation immediately after exercise, the sweaty body was gradually warm and not cold." In the sensory evaluation, it was confirmed that the use of the topical skin preparation of the present invention increased the sensation of a rise in body temperature after exercise. The sensation of a rise in body surface temperature due to use of the topical skin preparation was particularly noticeable in women.

Examples of formulations of the topical skin preparations of the present invention are shown below. In the formulation examples, "%" indicates "% by weight."
Formulation example 1 (gel cream)
Purified water, remaining ethanol 10%
Squalane 5%
Cetyl ethylhexanoate 1%
Carbomer 0.5%
Dimethicone 0.5%
BG 5%
DPG 5%
TEA Appropriate amount Phenoxyethanol 0.3%
PEG-20 sorbitan isostearate 0.5%
Sorbitan sesquioleate 0.4%
Hyaluronic acid 0.05%
Vanillyl butyl 0.02%
Tambourissa Trichophylla Leaf Extract 0.01%
Butterbur leaf/stem extract 0.005%
Lepidium meyenii extract 0.003%
Carnitine 0.1%
Hamamelis Leaf Extract 0.1%
Bergamot oil 0.1%

Formulation Example 2 (Gel)
Purified water, remaining ethanol 10%
1,3-propanediol 7%
Pentanediol 1%
Acrylic acid/alkyl methacrylate copolymer 0.7%
Xanthan gum 0.05%
TEA, appropriate amount, methylparaben, 0.1%
Polyoxyethylene hydrogenated castor oil 0.5%
Hyaluronic acid 0.01%
Vanillyl butyl 0.01%
Tambourissa Trichophylla Leaf Extract 0.05%
Butterbur leaf/stem extract 0.001%
Lepidium meyenii extract 0.001%
Carnitine 0.2%
l-Menthol 0.2%
Eucalyptus oil 0.05%
Fragrance: 0.1%

Formulation example 3 (gel)
Purified water, remaining ethanol 10%
1,3-propanediol 5%
Pentanediol 1%
Acrylic acid/alkyl methacrylate copolymer 0.5%
Xanthan gum 0.05%
TEA, appropriate amount, methylparaben, 0.1%
Polyoxyethylene hydrogenated castor oil 0.5%
Hyaluronic acid 0.01%
Phytosonic (Sederma) 0.1%
Korean ginseng extract 0.01%
Butterbur leaf/stem extract 0.001%
Lepidium meyenii extract 0.001%
Carnitine 0.2%
l-Menthol 0.2%
Grapefruit oil 0.05%
Fragrance: 0.1%

Formulation Example 4 (Gel)
Purified water, remaining ethanol 8%
BG 10%
DPG 5%
Acrylic acid/alkyl methacrylate copolymer 0.5%
Xanthan gum 0.05%
TEA, appropriate amount, methylparaben, 0.1%
Polyoxyethylene hydrogenated castor oil 0.5%
Hyaluronic acid 0.02%
Nonanoic acid vanillylamide 0.005%
Angelica keiskei extract 0.1%
Butterbur leaf/stem extract 0.001%
Carrot extract 0.001%
Carnitine 0.2%
l-Menthol 0.2%
Lavender oil 0.05%
Fragrance: 0.1%

Formulation Example 5 (Lotion)
Purified water, remaining ethanol 3%
1,3-propanediol 7%
Glycerin 3%
Pentanediol 1%
Carrageenan 0.05%
Methylparaben 0.2%
Polyoxyethylene hydrogenated castor oil 0.3%
Capsicum extract 0.001%
Tambourissa Trichophylla Leaf Extract 0.0001%
Butterbur leaf/stem extract 0.0005%
Lepidium meyenii extract 0.005%
Carnitine 0.05%
Fragrance: 0.05%

Formulation Example 6 (lotion)
Purified water, remaining amount is Vaseline 5%
Liquid paraffin 2%
Caprylic/capric triglyceride 3%
Hydroxyethylcellulose 0.5%
Dimethicone 0.5%
BG 5%
Glycerin 5%
TEA Appropriate amount Hexanediol 2%
Phenoxyethanol 0.5%
PEG-20 sorbitan isostearate 1%
Glyceryl stearate 0.5%
Vanillyl butyl 0.005%
Tambourissa Trichophylla Leaf Extract 0.03%
Butterbur leaf/stem extract 0.01%
Lepidium meyenii extract 0.001%
Carnitine 0.01%
Tea extract 0.05%
Camphor 0.01%
Fragrance: 0.1%

Formulation Example 7 (Spray)
Purified water, remaining ethanol 40%
BG 5%
PPG-6 decyltetradeceth 0.3%
Hyaluronic acid 0.01%
Vanillyl butyl 0.03%
Tambourissa Trichophylla Leaf Extract 0.001%
Butterbur leaf/stem extract 0.001%
Lepidium meyenii extract 0.005%
Carnitine 0.005%
l-Menthol 0.5%
Bergamot oil 0.05%
Fragrance: 0.05%
Talc 3%

Formulation Example 8 (Gel)
Purified water, remaining ethanol 10%
1,3-butylene glycol 5%
Pentanediol 1.5%
Acrylic acid/alkyl methacrylate copolymer 0.6%
Hydroxyethyl cellulose 0.1%
TEA, appropriate amount, methylparaben, 0.05%
Polyoxyethylene hydrogenated castor oil 0.5%
Hyaluronic acid 0.01%
Vanillyl butyl 0.01%
Tambourissa Trichophylla Leaf Extract 0.05%
Butterbur leaf/stem extract 0.001%
Stevia extract 0.001%
Carnitine 0.2%
l-Menthol 0.2%
Eucalyptus oil 0.05%
Fragrance: 0.1%

Formulation Example 9 (Gel Cream)
Purified water, remaining ethanol 8%
Squalane 5%
Cetyl ethylhexanoate 1%
Carbomer 0.5%
Dimethicone 0.2%
1,3-butylene glycol 5%
DPG 2%
TEA Appropriate amount Phenoxyethanol 0.3%
PEG-20 sorbitan isostearate 0.5%
Sorbitan sesquioleate 0.4%
Hyaluronic acid 0.05%
Vanillyl butyl 0.02%
Bacillus/soybean fermentation extract 0.01%
Tambourissa Trichophylla Leaf Extract 0.05%
Lepidium meyenii extract 0.003%
Carnitine 0.1%
Grapefruit oil 0.05%
Bergamot oil 0.03%

By applying the topical skin preparation of the present invention to the skin during exercise, the effects of exercise are sustained or improved. Therefore, even light exercise can have a significant effect, resulting in a greater sense of satisfaction. In recent years, the number of people who exercise has increased, and most people now do light exercise, so the topical skin preparation of the present invention is a highly valuable product that meets these needs.

Claims (2)

A skin topical preparation comprising (A) a component that promotes fat burning and (B) a component that promotes sweating, wherein (A) the component that promotes fat burning is (A1) Chrysanthellum indicum extract, (A2) L-carnitine , and (A3) Lepidium meyenii extract , and (B) the component that promotes sweating is Tambourissa trichophylla leaf extract, and Butterbur leaf/stem extract . A method for sustaining or improving the effects of exercise, comprising a step of applying to the skin during exercise an external skin preparation containing (A) a component that promotes fat burning and (B) a component that promotes sweating, wherein (A) the component that promotes fat burning is (A1) Chrysanthellum indicum extract, (A2) L-carnitine , and (A3) Lepidium meyenii extract , and (B) the component that promotes sweating is Tambourissa trichophylla leaf extract, and Butterbur leaf/stem extract .

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