TR200707263T2 - Uzun sürede dışarıya yayılan eritromisin türevi formülleri. - Google Patents
Uzun sürede dışarıya yayılan eritromisin türevi formülleri.Info
- Publication number
- TR200707263T2 TR200707263T2 TR2007/07263T TR200707263T TR200707263T2 TR 200707263 T2 TR200707263 T2 TR 200707263T2 TR 2007/07263 T TR2007/07263 T TR 2007/07263T TR 200707263 T TR200707263 T TR 200707263T TR 200707263 T2 TR200707263 T2 TR 200707263T2
- Authority
- TR
- Turkey
- Prior art keywords
- clarithromycin
- long
- erythromycin derivative
- term spreading
- derivative formulas
- Prior art date
Links
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title 1
- 230000007774 longterm Effects 0.000 title 1
- AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 abstract 4
- 229960002626 clarithromycin Drugs 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000009792 diffusion process Methods 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Abstract
Klaritromİsinin gastrointestinal ortamda uzun sürede yayılması için farmakolojik bir bileşim olup, özelliği bu bileşimin aşağıdakileri içermesi (a) klaritromisin, ve (b) ağırlık itibariyle yaklaşık %5 ila yaklaşık %50 farmakolojik olarak kabul edilebilir bir polımer, ve oral yoldan alındığında klaritromisinin hızlı yayılan bileşimlerine hemen hemen eşit biouygunluk sağlarken, plazma içinde klaritromisinin hızlı yayılan bir bileşiminden istatistiksel olarak anlamlı bir şekilde, daha düşük ortalama dalgalanma indeksi oluşturmasıdır.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/838,900 US6010718A (en) | 1997-04-11 | 1997-04-11 | Extended release formulations of erythromycin derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200707263T2 true TR200707263T2 (tr) | 2008-01-21 |
Family
ID=25278344
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR1999/02149T TR199902149T2 (tr) | 1997-04-11 | 1998-03-06 | Uzun sürede disariya yayilan eritromisin türevi formülleri. |
| TR2007/07263T TR200707263T2 (tr) | 1997-04-11 | 1998-03-06 | Uzun sürede dışarıya yayılan eritromisin türevi formülleri. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR1999/02149T TR199902149T2 (tr) | 1997-04-11 | 1998-03-06 | Uzun sürede disariya yayilan eritromisin türevi formülleri. |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6010718A (tr) |
| EP (2) | EP1340495B1 (tr) |
| JP (2) | JP4394754B2 (tr) |
| KR (1) | KR100484559B1 (tr) |
| CN (1) | CN100408044C (tr) |
| AR (1) | AR012358A1 (tr) |
| AT (1) | ATE253371T1 (tr) |
| AU (1) | AU737324B2 (tr) |
| BG (1) | BG65188B1 (tr) |
| BR (1) | BR9807974A (tr) |
| CA (1) | CA2285266C (tr) |
| CO (1) | CO4940403A1 (tr) |
| CZ (1) | CZ294333B6 (tr) |
| DE (1) | DE69819481T2 (tr) |
| DK (1) | DK0973527T3 (tr) |
| ES (1) | ES2205454T3 (tr) |
| HU (1) | HUP0001382A3 (tr) |
| IL (3) | IL131616A0 (tr) |
| NO (1) | NO994946D0 (tr) |
| NZ (3) | NZ537410A (tr) |
| PL (2) | PL336142A1 (tr) |
| PT (1) | PT973527E (tr) |
| SA (1) | SA98190065B1 (tr) |
| SK (2) | SK288109B6 (tr) |
| TR (2) | TR199902149T2 (tr) |
| TW (1) | TW576743B (tr) |
| WO (1) | WO1998046239A1 (tr) |
| ZA (1) | ZA982916B (tr) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6551616B1 (en) | 1997-04-11 | 2003-04-22 | Abbott Laboratories | Extended release formulations of erythromycin derivatives |
| AU773863B2 (en) * | 1997-04-11 | 2004-06-10 | Bgp Products Operations Gmbh | Extended release formulations of erythromycin derivatives |
| US6099859A (en) * | 1998-03-20 | 2000-08-08 | Andrx Pharmaceuticals, Inc. | Controlled release oral tablet having a unitary core |
| TR200000054A2 (tr) * | 2000-01-05 | 2001-08-21 | Sanovel İlaç San. Ve Ti̇c. Anoni̇m Şi̇rketi̇ | Klaritromisin içeren sürekli salım sağlayan tablet formülasyonları. |
| US6544555B2 (en) * | 2000-02-24 | 2003-04-08 | Advancis Pharmaceutical Corp. | Antibiotic product, use and formulation thereof |
| US6565882B2 (en) * | 2000-02-24 | 2003-05-20 | Advancis Pharmaceutical Corp | Antibiotic composition with inhibitor |
| WO2001064224A1 (en) * | 2000-02-29 | 2001-09-07 | Teva Pharmaceutical Industries Ltd. | Processes for preparing clarithromycin and clarithromycin intermediate, essentially oxime-free clarithromycin, and pharmaceutical composition comprising the same |
| ATE432691T1 (de) * | 2000-03-28 | 2009-06-15 | Sandoz Ag | Geschmackmaskierte granulierte teilchen |
| IN192748B (tr) * | 2000-08-29 | 2004-05-15 | Ranbaxy Lab Ltd | |
| CA2425688A1 (en) * | 2000-10-13 | 2002-05-16 | Donald J. Treacy Jr. | Extended release erythromycin derivatives |
| US20020068078A1 (en) * | 2000-10-13 | 2002-06-06 | Rudnic Edward M. | Antifungal product, use and formulation thereof |
| US6541014B2 (en) * | 2000-10-13 | 2003-04-01 | Advancis Pharmaceutical Corp. | Antiviral product, use and formulation thereof |
| US6790459B1 (en) | 2000-11-03 | 2004-09-14 | Andrx Labs, Llc | Methods for treating diabetes via administration of controlled release metformin |
| US6866866B1 (en) | 2000-11-03 | 2005-03-15 | Andrx Labs, Llc | Controlled release metformin compositions |
| US20060034922A1 (en) * | 2000-11-03 | 2006-02-16 | Andrx Labs, Llc | Controlled release metformin compositions |
| US20020197314A1 (en) * | 2001-02-23 | 2002-12-26 | Rudnic Edward M. | Anti-fungal composition |
| US6673369B2 (en) | 2001-08-29 | 2004-01-06 | Ranbaxy Laboratories Limited | Controlled release formulation |
| BR0212259A (pt) * | 2001-08-29 | 2004-10-19 | Ranbaxy Lab Ltd | Formulação de liberação controlada de claritromicina ou tinidazol |
| US20050233003A1 (en) * | 2001-09-28 | 2005-10-20 | Solubest Ltd. | Hydrophilic dispersions of nanoparticles of inclusion complexes of salicylic acid |
| US20050191359A1 (en) * | 2001-09-28 | 2005-09-01 | Solubest Ltd. | Water soluble nanoparticles and method for their production |
| US20050227911A1 (en) * | 2001-09-28 | 2005-10-13 | Solubest Ltd. | Hydrophilic dispersions of nanoparticles of inclusion complexes of macromolecules |
| US6878693B2 (en) * | 2001-09-28 | 2005-04-12 | Solubest Ltd. | Hydrophilic complexes of lipophilic materials and an apparatus and method for their production |
| US20050249786A1 (en) * | 2001-09-28 | 2005-11-10 | Solubest Ltd. | Hydrophilic dispersions of nanoparticles of inclusion complexes of amorphous compounds |
| CA2465405A1 (en) * | 2001-11-02 | 2003-05-08 | Wockhardt Limited | Controlled release compositions for macrolide antimicrobial agents |
| US7700851B2 (en) * | 2001-11-13 | 2010-04-20 | U.S. Smokeless Tobacco Company | Tobacco nicotine demethylase genomic clone and uses thereof |
| PL223471B1 (pl) * | 2002-03-15 | 2016-10-31 | Cypress Bioscience Inc | Kompozycja farmaceutyczna zawierająca milnacypran do stosowania w leczeniu zespołu nadwrażliwości jelita grubego |
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| AU2003245504A1 (en) * | 2002-06-14 | 2003-12-31 | Andrx Corporation | Pharmaceutical compositions for drugs having ph-dependentsolubility |
| US20060003004A1 (en) * | 2002-10-25 | 2006-01-05 | Collegium Pharmaceutical, Inc. | Pulsatile release compositions of milnacipran |
| US20040121010A1 (en) * | 2002-10-25 | 2004-06-24 | Collegium Pharmaceutical, Inc. | Pulsatile release compositions of milnacipran |
| US20040191302A1 (en) | 2003-03-28 | 2004-09-30 | Davidson Robert S. | Method and apparatus for minimizing heat, moisture, and shear damage to medicants and other compositions during incorporation of same with edible films |
| US9561182B2 (en) * | 2003-08-22 | 2017-02-07 | Cure Pharmaceutical Corporation | Edible films for administration of medicaments to animals, methods for their manufacture and methods for their use for the treatment of animals |
| US8999372B2 (en) * | 2002-11-14 | 2015-04-07 | Cure Pharmaceutical Corporation | Methods for modulating dissolution, bioavailability, bioequivalence and drug delivery profile of thin film drug delivery systems, controlled-release thin film dosage formats, and methods for their manufacture and use |
| US20040131662A1 (en) | 2003-11-12 | 2004-07-08 | Davidson Robert S. | Method and apparatus for minimizing heat, moisture, and shear damage to medicants and other compositions during incorporation of same with edible films |
| WO2004067039A1 (en) * | 2003-01-28 | 2004-08-12 | Collegium Pharmaceutical, Inc. | Multiparticulate compositions of milnacipran for oral administration |
| US20040185097A1 (en) * | 2003-01-31 | 2004-09-23 | Glenmark Pharmaceuticals Ltd. | Controlled release modifying complex and pharmaceutical compositions thereof |
| BRPI0410098A (pt) * | 2003-05-06 | 2006-05-16 | Nirmal Mulye | formulação de liberação controlada de derivados de eritromicina |
| US7063862B2 (en) * | 2003-06-03 | 2006-06-20 | Biokey, Inc. | Pharmaceutical composition and method for treating |
| AU2004249211A1 (en) * | 2003-06-16 | 2004-12-29 | Andrx Pharmaceuticals, Llc | Oral extended-release composition |
| US20050053658A1 (en) * | 2003-09-09 | 2005-03-10 | Venkatesh Gopi M. | Extended release systems for macrolide antibiotics |
| CA2533178C (en) * | 2003-07-21 | 2014-03-11 | Advancis Pharmaceutical Corporation | Antibiotic product, use and formulation thereof |
| US8425936B2 (en) * | 2003-07-21 | 2013-04-23 | Shionogi Inc. | Antibiotic product, use and formulation thereof |
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| WO2005023221A1 (en) * | 2003-09-05 | 2005-03-17 | Ranbaxy Laboratories Limited | Clarithromycin formulations having improved biovailability |
| WO2005027877A1 (en) * | 2003-09-15 | 2005-03-31 | Advancis Pharmaceutical Corporation | Antibiotic product, use and formulation thereof |
| US8168228B2 (en) * | 2003-10-17 | 2012-05-01 | Sandoz Ag | Antibiotic clarithromycin micropellet compositions |
| US20050084540A1 (en) * | 2003-10-17 | 2005-04-21 | Indranil Nandi | Taste masking antibiotic composition |
| AU2004286855B2 (en) | 2003-10-29 | 2011-04-21 | Wyeth | Sustained release pharmaceutical compositions comprising aplindore and derivatives thereof |
| US20050101547A1 (en) * | 2003-11-06 | 2005-05-12 | Sadatrezaei Mohsen | Stabilized azithromycin composition |
| US6984403B2 (en) * | 2003-12-04 | 2006-01-10 | Pfizer Inc. | Azithromycin dosage forms with reduced side effects |
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| WO2005053639A2 (en) * | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Controlled release multiparticulates formed with dissolution enhancers |
| CA2549225A1 (en) * | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Spray-congeal process using an extruder for preparing multiparticulate crystalline drug compositions containing preferably a poloxamer and a glyceride |
| CA2547597A1 (en) * | 2003-12-04 | 2005-06-16 | Pfizer Products Inc. | Multiparticulate compositions with improved stability |
| RU2006119464A (ru) * | 2003-12-04 | 2007-12-20 | Пфайзер Продактс Инк. (Us) | Способ распыления-охлаждения с применением экструдера для получения композиций азитромицина в мультичастицах, предпочтительно содержащих полоксамер и глицерид |
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| KR20060092281A (ko) * | 2003-12-04 | 2006-08-22 | 화이자 프로덕츠 인크. | 액체 기초 방법에 의한 아지트로마이신 복합입자 투여형 |
| US7943585B2 (en) | 2003-12-22 | 2011-05-17 | Sandoz, Inc. | Extended release antibiotic composition |
| WO2005062898A2 (en) * | 2003-12-24 | 2005-07-14 | Advancis Pharmaceutical Corporation | Enhanced absorption of modified release dosage forms |
| BRPI0508743A (pt) * | 2004-03-24 | 2008-01-22 | Lupin Ltd | composição farmacêutica com uma liberação estendida de eritromicina ou um derivado da mesma, método para o uso de uma composição farmacêutica e processo para a preparação de uma composição farmacêutica |
| US20050260263A1 (en) * | 2004-05-18 | 2005-11-24 | Panion & Bf Biotech Inc. | Sustained release formulation for sparingly soluble main drugs |
| KR101122096B1 (ko) * | 2004-05-20 | 2012-03-15 | 주식회사종근당 | 쓴맛을 차폐하면서 우수한 용출률을 보이는클라리스로마이신의 약제학적 조성물 및 그의 제조 방법 |
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| WO2006014427A1 (en) * | 2004-07-02 | 2006-02-09 | Advancis Pharmaceutical Corporation | Tablet for pulsed delivery |
| US8778924B2 (en) * | 2006-12-04 | 2014-07-15 | Shionogi Inc. | Modified release amoxicillin products |
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| JP2009539866A (ja) * | 2006-06-05 | 2009-11-19 | オースペックス・ファーマシューティカルズ・インコーポレイテッド | 置換エリスロマイシンアナログの調製および有用性 |
| EP2283824B1 (en) | 2009-07-30 | 2017-04-19 | Special Products Line S.p.A. | Compositions and formulations based on swellable matrices for sustained release of poorly soluble drugs such as clarithromycin |
| EP2671571A1 (en) | 2012-06-05 | 2013-12-11 | Sanovel Ilac Sanayi ve Ticaret A.S. | Controlled-release formulations of clarithromycin |
| EP3784227A4 (en) * | 2018-04-25 | 2022-03-02 | Neurocentria, Inc. | MAGNESIUM THREONATE COMPOSITIONS AND THEIR USES |
| ES3052394T3 (en) * | 2020-07-13 | 2026-01-07 | Kirin Holdings Kk | Film coated tablet |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3870790A (en) * | 1970-01-22 | 1975-03-11 | Forest Laboratories | Solid pharmaceutical formulations containing hydroxypropyl methyl cellulose |
| US4226849A (en) * | 1979-06-14 | 1980-10-07 | Forest Laboratories Inc. | Sustained release therapeutic compositions |
| US4369172A (en) * | 1981-12-18 | 1983-01-18 | Forest Laboratories Inc. | Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose |
| ATE66143T1 (de) * | 1985-01-11 | 1991-08-15 | Abbott Lab | Feste zubereitung mit langsamer freisetzung. |
| FR2585948B1 (fr) * | 1985-08-06 | 1988-12-16 | Pf Medicament | Procede de fabrication de comprimes d'indometacine |
| US4808411A (en) * | 1987-06-05 | 1989-02-28 | Abbott Laboratories | Antibiotic-polymer compositions |
| US4925675A (en) | 1988-08-19 | 1990-05-15 | Himedics, Inc. | Erythromycin microencapsulated granules |
| JP3265680B2 (ja) * | 1992-03-12 | 2002-03-11 | 大正製薬株式会社 | 経口製剤用組成物 |
| US5393765A (en) * | 1993-12-13 | 1995-02-28 | Hoffmann-La Roche Inc. | Pharmaceutical compositions with constant erosion volume for zero order controlled release |
| ATE209497T1 (de) * | 1994-05-06 | 2001-12-15 | Pfizer | Azithromycin enthaltende arzneiverabreichungsformen mit gesteuerter wirkstoffabgabe |
| JPH0995440A (ja) * | 1995-09-29 | 1997-04-08 | Roussel Morishita Kk | 徐放性製剤およびその製造方法 |
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| US5972389A (en) * | 1996-09-19 | 1999-10-26 | Depomed, Inc. | Gastric-retentive, oral drug dosage forms for the controlled-release of sparingly soluble drugs and insoluble matter |
-
1997
- 1997-04-11 US US08/838,900 patent/US6010718A/en not_active Expired - Lifetime
-
1998
- 1998-03-06 KR KR10-1999-7009335A patent/KR100484559B1/ko not_active Expired - Fee Related
- 1998-03-06 SK SK1380-99A patent/SK288109B6/sk not_active IP Right Cessation
- 1998-03-06 AT AT98907722T patent/ATE253371T1/de active
- 1998-03-06 CZ CZ19993471A patent/CZ294333B6/cs not_active IP Right Cessation
- 1998-03-06 PL PL98336142A patent/PL336142A1/xx not_active IP Right Cessation
- 1998-03-06 DE DE69819481T patent/DE69819481T2/de not_active Revoked
- 1998-03-06 CA CA002285266A patent/CA2285266C/en not_active Expired - Lifetime
- 1998-03-06 PL PL402949A patent/PL402949A1/pl not_active Application Discontinuation
- 1998-03-06 BR BR9807974-3A patent/BR9807974A/pt not_active Application Discontinuation
- 1998-03-06 SK SK5021-2010A patent/SK288127B6/sk not_active IP Right Cessation
- 1998-03-06 NZ NZ537410A patent/NZ537410A/en not_active IP Right Cessation
- 1998-03-06 AU AU63463/98A patent/AU737324B2/en not_active Expired
- 1998-03-06 EP EP03008281.2A patent/EP1340495B1/en not_active Expired - Lifetime
- 1998-03-06 TR TR1999/02149T patent/TR199902149T2/tr unknown
- 1998-03-06 WO PCT/US1998/004373 patent/WO1998046239A1/en not_active Ceased
- 1998-03-06 ES ES98907722T patent/ES2205454T3/es not_active Expired - Lifetime
- 1998-03-06 PT PT98907722T patent/PT973527E/pt unknown
- 1998-03-06 NZ NZ337120A patent/NZ337120A/en not_active IP Right Cessation
- 1998-03-06 TR TR2007/07263T patent/TR200707263T2/tr unknown
- 1998-03-06 EP EP98907722A patent/EP0973527B1/en not_active Revoked
- 1998-03-06 JP JP54388298A patent/JP4394754B2/ja not_active Expired - Fee Related
- 1998-03-06 CN CNB03157906XA patent/CN100408044C/zh not_active Expired - Fee Related
- 1998-03-06 IL IL13161698A patent/IL131616A0/xx unknown
- 1998-03-06 DK DK98907722T patent/DK0973527T3/da active
- 1998-03-06 NZ NZ596215A patent/NZ596215A/xx not_active IP Right Cessation
- 1998-03-06 HU HU0001382A patent/HUP0001382A3/hu unknown
- 1998-03-17 TW TW087103954A patent/TW576743B/zh not_active IP Right Cessation
- 1998-04-06 ZA ZA982916A patent/ZA982916B/xx unknown
- 1998-04-07 AR ARP980101591A patent/AR012358A1/es not_active Application Discontinuation
- 1998-04-08 CO CO98019851A patent/CO4940403A1/es unknown
- 1998-05-16 SA SA98190065A patent/SA98190065B1/ar unknown
-
1999
- 1999-08-26 IL IL131616A patent/IL131616A/en not_active IP Right Cessation
- 1999-10-11 NO NO994946A patent/NO994946D0/no unknown
- 1999-11-05 BG BG103862A patent/BG65188B1/bg unknown
-
2009
- 2009-01-07 JP JP2009001631A patent/JP5188994B2/ja not_active Expired - Fee Related
-
2012
- 2012-11-14 IL IL223035A patent/IL223035A0/en unknown
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