[go: up one dir, main page]

TR200102273T2 - GNRH-II ihtiva eden kontrollü salınış formülasyonu. - Google Patents

GNRH-II ihtiva eden kontrollü salınış formülasyonu.

Info

Publication number
TR200102273T2
TR200102273T2 TR2001/02273T TR200102273T TR200102273T2 TR 200102273 T2 TR200102273 T2 TR 200102273T2 TR 2001/02273 T TR2001/02273 T TR 2001/02273T TR 200102273 T TR200102273 T TR 200102273T TR 200102273 T2 TR200102273 T2 TR 200102273T2
Authority
TR
Turkey
Prior art keywords
controlled release
release formulation
formulation containing
xaa1
xaa3
Prior art date
Application number
TR2001/02273T
Other languages
English (en)
Inventor
Qi Steve
Akinsanya Karen
Hayward Amanda
Original Assignee
Ferring B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring B.V. filed Critical Ferring B.V.
Publication of TR200102273T2 publication Critical patent/TR200102273T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

Bir terapötik peptidin veya tuzunun kontrollü salinisi için bir farmasötik formülasyon; bu peptit asagidaki diziyi haizdir: pyroGlu-His-Trp-Ser-Xaa1-Gly-Xaa2-Xaa3-Pro-Gly-NH2; bu dizide: Xaa1 His veya Tyr'dir; Xaa2 Trp veya Leu'dur; ve Xaa3 Tyr veya Arg'dir. Burada sart Xaa1 Tyr ve Xaa2 Leu oldugunda Xaa3 Arg degildir. Bu formülasyon ayrica farmasötik olarak kabul edilebilir, biyolojik olarak parçalanabilir bir polimer ihtiva eder.
TR2001/02273T 1998-12-03 1999-12-02 GNRH-II ihtiva eden kontrollü salınış formülasyonu. TR200102273T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9826662A GB2344287A (en) 1998-12-03 1998-12-03 Controlled release pharmaceutical formulation

Publications (1)

Publication Number Publication Date
TR200102273T2 true TR200102273T2 (tr) 2001-12-21

Family

ID=10843631

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/02273T TR200102273T2 (tr) 1998-12-03 1999-12-02 GNRH-II ihtiva eden kontrollü salınış formülasyonu.

Country Status (22)

Country Link
EP (1) EP1140133A1 (tr)
JP (1) JP2002531411A (tr)
KR (1) KR20010089538A (tr)
CN (1) CN1332635A (tr)
AU (1) AU770676B2 (tr)
BR (1) BR9915943A (tr)
CA (1) CA2353798A1 (tr)
CZ (1) CZ20011893A3 (tr)
EE (1) EE200100293A (tr)
GB (1) GB2344287A (tr)
HR (1) HRP20010421A2 (tr)
HU (1) HUP0104943A3 (tr)
IL (1) IL143496A0 (tr)
MX (1) MXPA01005543A (tr)
NO (1) NO20012636L (tr)
NZ (1) NZ511984A (tr)
PL (1) PL348575A1 (tr)
RU (1) RU2233170C2 (tr)
SK (1) SK7552001A3 (tr)
TR (1) TR200102273T2 (tr)
WO (1) WO2000032218A1 (tr)
ZA (1) ZA200104530B (tr)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2614532A1 (en) 2005-07-26 2007-02-01 Georg-August-Universitaet Goettingen Method for induction and enhancement of apoptosis in tumor cells
GB0616111D0 (en) 2006-06-16 2006-09-20 Ardana Bioscience Ltd Agents, methods and uses
EP2411038B1 (en) 2009-03-27 2016-12-28 Van Andel Research Institute Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use
WO2011032099A1 (en) 2009-09-11 2011-03-17 The Board Of Trustees Of The University Of Illinois Methods of treating diastolic dysfunction and related conditions
US20120208762A1 (en) 2009-10-27 2012-08-16 The Board Of Trustees Of The University Of Illinois Methods of Diagnosing Diastolic Dysfunction
EP2512503A4 (en) 2009-12-18 2013-08-21 Univ Indiana Res & Tech Corp COAGONISTS OF GLUCAGON / GLP-1 RECEPTOR
CA2788304A1 (en) 2010-01-27 2011-08-04 Indiana University Research And Technology Corporation Glucagon antagonist - gip agonist conjugates and compositions for the treatment of metabolic disorders and obesity
WO2011116026A2 (en) 2010-03-15 2011-09-22 The Board Of Trustees Of The University Of Illinois Inhibitors of beta integrin-g protein alpha subunit binding interactions
AU2011268327B2 (en) 2010-06-16 2016-02-25 Indiana University Research And Technology Corporation Single chain insulin agonists exhibiting high activity at the insulin receptor
US20120004182A1 (en) 2010-07-02 2012-01-05 Carsten Gruendker Pharmaceutical compositions and methods for induction and enhancement of apoptosis in tumor cells
WO2012087943A2 (en) 2010-12-20 2012-06-28 The Regents Of The University Of Michigan Inhibitors of the epidermal growth factor receptor-heat shock protein 90 binding interaction
ES2713952T3 (es) 2010-12-22 2019-05-24 Univ Indiana Res & Tech Corp Análogos de glucagón que muestran actividad de receptor de GIP
HRP20170890T1 (hr) 2011-06-22 2017-09-08 Indiana University Research And Technology Corporation Suagonisti glukagonskog/glp-1 receptora
US9415123B2 (en) 2011-10-10 2016-08-16 The Regents Of The University Of Michigan Polymeric nanoparticles for ultrasound imaging and therapy
WO2013074910A1 (en) 2011-11-17 2013-05-23 Indiana University Research And Technology Corporation Glucagon superfamily peptides exhibiting glucocorticoid receptor activity
EP2793932B1 (en) 2011-12-20 2018-10-03 Indiana University Research and Technology Corporation Ctp-based insulin analogs for treatment of diabetes
AU2013274078A1 (en) 2012-06-14 2015-01-29 Ambrx, Inc. Anti-PSMA antibodies conjugated to nuclear receptor ligand polypeptides
AR091478A1 (es) 2012-06-21 2015-02-04 Univ Indiana Res & Tech Corp Analogos de glucagon que exhiben actividad de receptor de gip (peptido insulinotropico dependiente de glucosa)
WO2013192129A1 (en) 2012-06-21 2013-12-27 Indiana University Research And Technology Corporation Glucagon analogs exhibiting gip receptor activity
WO2014052451A2 (en) 2012-09-26 2014-04-03 Indiana University Research And Technology Corporation Insulin analog dimers
WO2014158900A1 (en) 2013-03-14 2014-10-02 Indiana University Research And Technology Corporation Insulin-incretin conjugates
US10189908B2 (en) 2014-02-05 2019-01-29 The University Of Chicago Chimeric antigen receptors recognizing cancer-specific TN glycopeptide variants
US10232020B2 (en) 2014-09-24 2019-03-19 Indiana University Research And Technology Corporation Incretin-insulin conjugates
CN107835820B (zh) 2015-01-26 2021-10-15 芝加哥大学 识别癌症特异性IL13Rα2的CAR T细胞
CN107683289B (zh) 2015-01-26 2021-08-06 芝加哥大学 IL13Rα2结合剂和其在癌症治疗中的用途
CN104789524A (zh) * 2015-04-30 2015-07-22 四川大学 骨质疏松大鼠原代成骨细胞分离培养方法及应用
US20180201937A1 (en) 2015-08-04 2018-07-19 The University Of Chicago Inhibitors of cacna1a/alpha1a subunit internal ribosomal entry site (ires) and methods of treating spinocerebellar ataxia type 6
EA201991738A1 (ru) * 2017-01-20 2020-02-11 Имьюн Систем Регулеишн Холдинг Аб Новые соединения (иммунорелины)
SMT202500067T1 (it) 2017-06-30 2025-03-12 Amgen Inc Metodi per trattare l'insufficienza cardiaca con attivatori del sarcomero cardiaco
IL312607B1 (en) 2017-08-03 2025-04-01 Amgen Inc Interleukin-21 Mutants and Treatment Methods
CN116003405A (zh) 2017-09-08 2023-04-25 美国安进公司 Kras g12c的抑制剂及其使用方法
EP4435009A3 (en) 2017-09-18 2025-02-26 The Regents of the University of California Claudin6 antibodies and methods of treating cancer
BR112020014121A2 (pt) 2018-01-12 2020-12-01 Amgen Inc. anticorpos anti-pd-1 e métodos de tratamento
US20200085776A1 (en) 2018-09-10 2020-03-19 Cardax, Inc. Methods of Reducing C-Reactive Protein and/or Treating Cardiovascular Disease
PL3941946T4 (pl) 2019-03-20 2025-05-26 The Regents Of The University Of California Przeciwciała klaudyny-6 i koniugat lekowy
WO2020191344A1 (en) 2019-03-20 2020-09-24 The Regents Of The University Of California Claudin-6 bispecific antibodies
CN112955181B (zh) * 2019-03-26 2024-08-13 新型医药公司 一种长效脂肪酸缀合的GnRH衍生物及含其的药物组合物
WO2020210376A1 (en) 2019-04-09 2020-10-15 The Board Of Trustees Of The University Of Illinois Drug adsorbed highly porous activated carbon for enhanced drug delivery
WO2020223177A1 (en) 2019-04-29 2020-11-05 The Board Of Trustees Of The University Of Illinois Mek inhibitors for corneal scarring and neovascularization
KR20220002316A (ko) 2019-04-30 2022-01-06 인스티튜토 데 메디시나 몰레큘라 조앙 로보 안투네스 Cdk 억제제와 조합된 rank 경로 억제제
WO2020263793A1 (en) 2019-06-24 2020-12-30 Amgen Inc. Inhibition of sirp-gamma for cancer treatment
EP4021454A1 (en) 2019-08-30 2022-07-06 Research Institute at Nationwide Children's Hospital Copper-atsm for treating neurodegenerative disorders associated with mitochondrial dysfunction
TW202216778A (zh) 2020-07-15 2022-05-01 美商安進公司 Ｔｉｇｉｔ及ｃｄ１１２ｒ阻斷
WO2022103966A1 (en) 2020-11-12 2022-05-19 Amgen Inc. Methods of treating heart failure by administering omecamtiv mecarbil
JP2024504696A (ja) 2021-01-20 2024-02-01 バイオアントレ エルエルシー Ｃｔｌａ４結合性タンパク質およびがんを処置する方法
WO2023137161A1 (en) 2022-01-14 2023-07-20 Amgen Inc. Triple blockade of tigit, cd112r, and pd-l1
US11986474B1 (en) 2023-06-27 2024-05-21 Cytokinetics, Incorporated Methods for treating heart failure by administering cardiac sarcomere activators

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH661206A5 (fr) * 1983-09-23 1987-07-15 Debiopharm Sa Procede pour la preparation d'un medicament destine au traitement de maladies hormonodependantes.
DE3414595A1 (de) * 1984-04-18 1985-10-31 Hoechst Ag, 6230 Frankfurt Verwendung von gonadoliberin und gonadoliberinagonisten zur behandlung klimakterischer beschwerden
US4540513A (en) * 1984-09-25 1985-09-10 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Decapeptide having gonadotropin releasing activity
US4721775A (en) * 1985-08-26 1988-01-26 Board Of Regents, The University Of Texas System Effective peptides related to the luteinizing hormone releasing hormone from L-amino acids
DE3634435A1 (de) * 1986-10-09 1988-04-14 Hoechst Ag Analoga von gonadoliberin mit verbesserter loeslichkeit, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
ZA918168B (en) * 1990-10-16 1993-04-14 Takeda Chemical Industries Ltd Prolonged release preparation and polymers thereof.
IT1243390B (it) * 1990-11-22 1994-06-10 Vectorpharma Int Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
CA2192773C (en) * 1995-12-15 2008-09-23 Hiroaki Okada Production of sustained-release preparation for injection
AU3388597A (en) * 1996-06-13 1998-01-07 University Of Cape Town Human type ii gonadotropin-releasing hormone receptor
US5932547A (en) * 1996-07-03 1999-08-03 Alza Corporation Non-aqueous polar aprotic peptide formulations
GB2343182A (en) * 1998-10-27 2000-05-03 Ferring Bv Use of GnRH-II and analogues thereof for the treatment of osteoporosis

Also Published As

Publication number Publication date
CZ20011893A3 (cs) 2002-05-15
IL143496A0 (en) 2002-04-21
WO2000032218A1 (en) 2000-06-08
BR9915943A (pt) 2001-08-21
HRP20010421A2 (en) 2002-06-30
PL348575A1 (en) 2002-06-03
KR20010089538A (ko) 2001-10-06
EP1140133A1 (en) 2001-10-10
NZ511984A (en) 2002-11-26
CA2353798A1 (en) 2000-06-08
SK7552001A3 (en) 2002-02-05
RU2233170C2 (ru) 2004-07-27
CN1332635A (zh) 2002-01-23
AU1573200A (en) 2000-06-19
NO20012636L (no) 2001-07-12
EE200100293A (et) 2002-08-15
GB2344287A (en) 2000-06-07
HUP0104943A2 (en) 2002-06-29
ZA200104530B (en) 2002-06-04
HUP0104943A3 (en) 2002-08-28
NO20012636D0 (no) 2001-05-29
AU770676B2 (en) 2004-02-26
MXPA01005543A (es) 2003-07-14
GB9826662D0 (en) 1999-01-27
JP2002531411A (ja) 2002-09-24

Similar Documents

Publication Publication Date Title
TR200102273T2 (tr) GNRH-II ihtiva eden kontrollü salınış formülasyonu.
MX9603858A (es) Copolimeros de bloque y de injerto y metodos relacionados con los mismos.
BG102022A (bg) Дозиращ инхалатор за салметерол
AU6819294A (en) Oral drug delivery compositions and methods
ATE249422T1 (de) Verbindungen und zusammensetzungen zur verabreichung aktiver stoffe
DE60231731D1 (de) Vorrichtung zur nasalen oder oralen verabreichung eines medikamentes
IL135258A0 (en) Bioadhesive compositions and methods for topical administration of active agents
DK1061900T3 (da) Dermale præparater
GT199900151A (es) Sistema de entrega controlado de droga administrado oralmente, que provee control temporal y espacial.
BR9714015A (pt) Formulações farmacêuticas para distribuição de droga prolongada
HU912990D0 (en) Medical preparation
EP0818991A4 (en) EXCIPIENT FOR INSUFFLATION, GRADUALLY RELEASED, FOR MEDICINES
EP1015008A4 (en) COMPOUNDS AND COMPOSITIONS FOR DELIVERY OF ACTIVE AGENTS
MXPA01007411A (es) Composiciones y metodos para suministro mucoso.
MX9602656A (es) Dispositivo transdermico que contiene pirrolidona polivinilica como mejorador de solubilidad.
ATE338771T1 (de) Antagonisten des intestinotrophen glp-2 peptides
DE69721481D1 (de) Wirkstoffformulierungen mit verzögerter freisetzung
GB9814527D0 (en) Delivery system
BR0308137A (pt) Formulações de droga de liberação constante contendo um peptìdeo veìculo
PT885014E (pt) Composicoes farmaceuticas contendo polimeros orto ester tamponados
BR0009472A (pt) Antagonistas de lhrh com propriedades desolubilidade aperfeiçoadas
RS70704A (en) Sustained/controlled release solid formulation as a novel drug delivery system with reduced risk of dose dumping
IL111928A (en) Long acting poorly soluble salts of peptides and pharmaceutical compositions containing them
AU7723700A (en) Non-mammalian gnrh analogs and uses thereof in regulation of fertility and pregnancy
EP1300143A4 (en) STAMP CONTAINING 4-BIPHENYLACETIC ACID