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TR200001793T2 - Yapısında değişiklik yapılmış tiyazolidinediyon türevi, bunun hazırlanması için işlem ve eczacılık alanında kullanımı - Google Patents

Yapısında değişiklik yapılmış tiyazolidinediyon türevi, bunun hazırlanması için işlem ve eczacılık alanında kullanımı

Info

Publication number
TR200001793T2
TR200001793T2 TR2000/01793T TR200001793T TR200001793T2 TR 200001793 T2 TR200001793 T2 TR 200001793T2 TR 2000/01793 T TR2000/01793 T TR 2000/01793T TR 200001793 T TR200001793 T TR 200001793T TR 200001793 T2 TR200001793 T2 TR 200001793T2
Authority
TR
Turkey
Prior art keywords
compound
preparation
pharmaceuticals
modified
composition
Prior art date
Application number
TR2000/01793T
Other languages
English (en)
Inventor
Marie Choudary Bernadette
Robert Lynch Ian
John Sasse Michael
Original Assignee
Smithkline Beecham P.L.C.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham P.L.C. filed Critical Smithkline Beecham P.L.C.
Publication of TR200001793T2 publication Critical patent/TR200001793T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

(i) molar denklerinin 0.3 ile 0.6 araliginda su içermesi ve (ii) 1757, 1331, 1290, 1211 ve 767 cm-1 de doruk noktalari içeren kizil ötesi spektrum vermesi ve/veya (111) 1758, 1610, 1394, 1316 ve 1289 cm-1 de doruk içeren Raman spektrumu vermesi ve/veya (iv) bu metinde büyük ölçüde Tablo I' de açiklanana benzer kimyasal degisimleri içeren kati hal nükleer manyetik rezonans septrumu vermesi ve/veya (v) burada büyük ölçüde Sekil IV'te açiklanan gibi X-isini toz daglim (XPRD) modeli vermesi ile tanimlanan, 5-(4-(2-(N-metil-N-(2-piridil) amino)etoksi)benzil) tiyazolidin, -2, 4-diyon bagsiz bazi ile maleik asit tuzunun hidrati, böyle bir birlesik maddenin hazirlanmasi için islem, böyle bir bilesik maddeyi içeren eczacilik teknigi bakimindan uygun bilesim ve böyle bir birlesik maddenin veya bilesimin tipta uygulanmasi.
TR2000/01793T 1997-12-16 1998-12-14 Yapısında değişiklik yapılmış tiyazolidinediyon türevi, bunun hazırlanması için işlem ve eczacılık alanında kullanımı TR200001793T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9726563.1A GB9726563D0 (en) 1997-12-16 1997-12-16 Novel pharmaceutical

Publications (1)

Publication Number Publication Date
TR200001793T2 true TR200001793T2 (tr) 2000-10-23

Family

ID=10823691

Family Applications (2)

Application Number Title Priority Date Filing Date
TR2000/01793T TR200001793T2 (tr) 1997-12-16 1998-12-14 Yapısında değişiklik yapılmış tiyazolidinediyon türevi, bunun hazırlanması için işlem ve eczacılık alanında kullanımı
TR1998/02624A TR199802624A3 (tr) 1997-12-16 1998-12-16 Yeni farmasötik.

Family Applications After (1)

Application Number Title Priority Date Filing Date
TR1998/02624A TR199802624A3 (tr) 1997-12-16 1998-12-16 Yeni farmasötik.

Country Status (37)

Country Link
US (4) US20020133016A1 (tr)
EP (1) EP1042321A1 (tr)
JP (1) JP2002508371A (tr)
KR (1) KR100549141B1 (tr)
CN (3) CN1285831A (tr)
AP (1) AP1363A (tr)
AR (2) AR017211A1 (tr)
AU (2) AU2272299A (tr)
BG (1) BG64850B1 (tr)
BR (1) BR9813598A (tr)
CA (1) CA2314967A1 (tr)
CO (1) CO4990943A1 (tr)
CZ (1) CZ300081B6 (tr)
DZ (1) DZ2679A1 (tr)
EA (1) EA002833B1 (tr)
EG (1) EG22250A (tr)
GB (1) GB9726563D0 (tr)
HR (1) HRP20000404A2 (tr)
HU (1) HUP0102292A3 (tr)
ID (1) ID24714A (tr)
IL (2) IL136425A (tr)
MA (1) MA26581A1 (tr)
MY (1) MY128573A (tr)
NO (1) NO317255B1 (tr)
NZ (1) NZ504703A (tr)
OA (1) OA11900A (tr)
PE (1) PE20000125A1 (tr)
PL (1) PL341213A1 (tr)
RS (1) RS50080B (tr)
SA (1) SA99200200B1 (tr)
SK (1) SK286422B6 (tr)
TR (2) TR200001793T2 (tr)
TW (1) TW487709B (tr)
UA (1) UA66821C2 (tr)
UY (2) UY25309A1 (tr)
WO (1) WO1999031093A1 (tr)
ZA (1) ZA9811504B (tr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE39384E1 (en) 1993-09-01 2006-11-07 Smithkline Beecham P.L.C. Substituted thiazolidinedione derivatives
US6664278B2 (en) 1997-12-16 2003-12-16 Smithkline Beecham P.L.C. Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt
US20020137940A1 (en) * 1997-12-16 2002-09-26 Smithkline Beecham P.L.C. 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical
GB9726568D0 (en) 1997-12-16 1998-02-11 Smithkline Beecham Plc Novel pharmaceutical
GB9909041D0 (en) * 1999-04-20 1999-06-16 Smithkline Beecham Plc Novel pharmaceutical
US20040248945A1 (en) 1999-04-23 2004-12-09 Smithkline Beecham P.L.C. Thiazolidinedione derivative and its use as antidiabetic
PL351685A1 (en) * 1999-04-23 2003-06-02 Smithkline Beecham Plc Novel pharmaceutical
MXPA01010821A (es) * 1999-04-23 2003-09-04 Smithkline Beecham Plc Forma poliformica de sal de acido maleico de 5-[4-[2 -(n-metil -n-(2- piridil) amino ) etoxi] bencil ] tiazolidin-2, 4-diona.
OA11871A (en) * 1999-04-23 2006-03-27 Smithkline Beecham Plc Novel pharmaceutical.
GB0014005D0 (en) * 2000-06-08 2000-08-02 Smithkline Beecham Plc Novel pharmaceutical
GB0021784D0 (en) * 2000-09-05 2000-10-18 Smithkline Beecham Plc Novel pharmaceutical
GB0021978D0 (en) * 2000-09-07 2000-10-25 Smithkline Beecham Plc Novel pharmaceutical
GB0129876D0 (en) * 2001-12-13 2002-02-06 Smithkline Beecham Plc Novel pharmaceutical
WO2003050112A1 (en) * 2001-12-13 2003-06-19 Smithkline Beecham Plc Toluenesulfonate hydrates of a thiazolidinedione derivative
KR100450700B1 (ko) * 2002-03-22 2004-10-01 주식회사종근당 티아졸리딘디온 유도체 화합물 및 이를 함유하는 약제학적조성물
EP1468997A3 (en) * 2003-04-18 2004-11-03 CHEMI S.p.A. Polymorphous forms of rosiglitazone maleate
GB2405403A (en) * 2003-08-29 2005-03-02 Cipla Ltd Rosiglitazone maleate of particular polymorphic forms and methods of preparing rosiglitazone free base
WO2005065663A1 (en) * 2003-12-31 2005-07-21 Alpharma, Inc. Rosiglitazone and metformin formulations
US20050163837A1 (en) * 2003-12-31 2005-07-28 Garth Boehm Rosiglitazone formulations
ITMI20041537A1 (it) * 2004-07-28 2004-10-28 Chemi Spa Nuova forma polimorfa del rosiglitazone maleato
CZ298424B6 (cs) * 2005-05-24 2007-09-26 Zentiva, A. S. Zpusob krystalizace rosiglitazonu a jeho derivátuze smesných rozpouštedel
US7435741B2 (en) * 2006-05-09 2008-10-14 Teva Pharmaceutical Industries, Ltd. 2-N{5-[[4-[2-(methyl-2-pyridinylamino) ethoxy] phenyl]methyl]-2,4-thiazolidinedione} butanedioic acid, methods of preparation and compositions with rosiglitazone maleate
EP2184055A1 (en) 2008-11-07 2010-05-12 LEK Pharmaceuticals d.d. Process for preparing solid dosage forms of rosiglitazone maleate

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6288095B1 (en) 1987-09-04 2001-09-11 Beecham Group P.L.C. Compounds
DE3856378T2 (de) 1987-09-04 2000-05-11 Beecham Group P.L.C., Brentford Substituierte Thiazolidindionderivate
GB8820389D0 (en) * 1988-08-26 1988-09-28 Beecham Group Plc Novel compounds
GB9124513D0 (en) * 1991-11-19 1992-01-08 Smithkline Beecham Plc Novel process
US5741803A (en) 1992-09-05 1998-04-21 Smithkline Beecham Plc Substituted thiazolidinedionle derivatives
GB9218830D0 (en) * 1992-09-05 1992-10-21 Smithkline Beecham Plc Novel compounds
DE4404198A1 (de) 1994-02-10 1995-08-17 Henkel Kgaa 2-Fluor-6-nitroaniline
EP0777469A1 (en) * 1994-02-10 1997-06-11 Smithkline Beecham Plc Use of insulin sensitisers for treating renal diseases
US20020137940A1 (en) 1997-12-16 2002-09-26 Smithkline Beecham P.L.C. 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical
US6664278B2 (en) 1997-12-16 2003-12-16 Smithkline Beecham P.L.C. Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt
IL155036A0 (en) 2000-09-26 2003-10-31 Reddy Research Foundation Polymorphic forms of 5-[4-[2-[n-methyl-n-(2-pyridyl) amino] ethoxy] benzyl] thiazolidine-2,4-dione maleate and pharmaceutical compositions containing the same

Also Published As

Publication number Publication date
AU2753802A (en) 2002-05-16
CN101318957A (zh) 2008-12-10
KR20010033140A (ko) 2001-04-25
IL160847A0 (en) 2004-08-31
KR100549141B1 (ko) 2006-02-03
PL341213A1 (en) 2001-03-26
US20030139604A1 (en) 2003-07-24
SK286422B6 (sk) 2008-09-05
AR017211A1 (es) 2001-08-22
US7368574B2 (en) 2008-05-06
CN1285831A (zh) 2001-02-28
NO20003070L (no) 2000-06-15
CZ300081B6 (cs) 2009-01-28
US20020133016A1 (en) 2002-09-19
AP2000001829A0 (en) 2000-06-30
WO1999031093A1 (en) 1999-06-24
EA200000656A1 (ru) 2000-12-25
HUP0102292A2 (hu) 2002-05-29
DZ2679A1 (fr) 2003-03-29
TW487709B (en) 2002-05-21
AP1363A (en) 2005-01-21
NO317255B1 (no) 2004-09-27
TR199802624A2 (tr) 1999-10-21
NZ504703A (en) 2002-12-20
EP1042321A1 (en) 2000-10-11
TR199802624A3 (tr) 1999-10-21
EG22250A (en) 2002-11-30
MY128573A (en) 2007-02-28
IL136425A (en) 2004-08-31
EA002833B1 (ru) 2002-10-31
NO20003070D0 (no) 2000-06-15
HRP20000404A2 (en) 2000-12-31
GB9726563D0 (en) 1998-02-11
MA26581A1 (fr) 2004-12-20
JP2002508371A (ja) 2002-03-19
BR9813598A (pt) 2000-10-10
HUP0102292A3 (en) 2003-12-29
AU770818B2 (en) 2004-03-04
CZ20002206A3 (cs) 2000-12-13
BG104606A (en) 2001-02-28
IL136425A0 (en) 2001-06-14
US20070037859A1 (en) 2007-02-15
ID24714A (id) 2000-08-03
YU36400A (sh) 2003-12-31
CN101318956A (zh) 2008-12-10
OA11900A (en) 2006-04-10
UY25309A1 (es) 1999-07-19
SK9182000A3 (en) 2000-12-11
US20050288513A1 (en) 2005-12-29
ZA9811504B (en) 2000-06-15
RS50080B (sr) 2009-01-22
PE20000125A1 (es) 2000-03-03
AU2272299A (en) 1999-07-05
UY25306A1 (es) 2000-12-29
CO4990943A1 (es) 2000-12-26
AR016161A1 (es) 2001-06-20
BG64850B1 (bg) 2006-06-30
UA66821C2 (uk) 2004-06-15
SA99200200B1 (ar) 2006-11-11
CA2314967A1 (en) 1999-06-24

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