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TR200000196T2 - Avermektin bileşiklerinin üretimi. - Google Patents

Avermektin bileşiklerinin üretimi.

Info

Publication number
TR200000196T2
TR200000196T2 TR2000/00196T TR200000196T TR200000196T2 TR 200000196 T2 TR200000196 T2 TR 200000196T2 TR 2000/00196 T TR2000/00196 T TR 2000/00196T TR 200000196 T TR200000196 T TR 200000196T TR 200000196 T2 TR200000196 T2 TR 200000196T2
Authority
TR
Turkey
Prior art keywords
compound
reacting
formula
production
agent
Prior art date
Application number
TR2000/00196T
Other languages
English (en)
Inventor
Honda Masanori
Kadoi Hiroshi
Morita Hiromasa
Nagakura Isao
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of TR200000196T2 publication Critical patent/TR200000196T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Bu bulus, formül (I)'in bir bilesiginin hazirlanmasi için bir islem olup, asagidaki asamalari kapsar: (a) bir avermektin B2 türevinin, yükseltgen bir ajanla, bir 5-okso bilesigi meydana getirmek üzere reaksiyona sokulmasi; (b) 5-okso bilesiginin, bir 5-imino bilesigini meydene getirmek üzere, R1'in H veya bir hidroksiimino- koruyucu grup oldugu, formül R1-O- NH2'nin bir bilesigiyle reaksiyona sokulmasi; (c) 5-imino bilesiginin, bir 4", 23- bistiyonokarbonil ester meydana getirmek üzere, bir tiyonokarbonize edici ajanla reaksiyona sokulmasi; (d) 4", 23-bistiyonokarbonil ester'in, bir 4", 23-dideoksi bilesigini meydana getirmek üzere, bir deoksijenleme ajani ile reaksiyona sokulmasi; ve' (e) 4", 23-dideoksi bilesiginin, formül (I)'in bir bilesigini meydana getirmek üzere, bir asitle reaksiyona sokulmasi. Formül (I).
TR2000/00196T 1997-07-23 1998-06-25 Avermektin bileşiklerinin üretimi. TR200000196T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB9700916 1997-07-23

Publications (1)

Publication Number Publication Date
TR200000196T2 true TR200000196T2 (tr) 2000-07-21

Family

ID=11004591

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/00196T TR200000196T2 (tr) 1997-07-23 1998-06-25 Avermektin bileşiklerinin üretimi.

Country Status (21)

Country Link
EP (1) EP1001962B8 (tr)
JP (1) JP3267634B2 (tr)
KR (1) KR100339191B1 (tr)
CN (1) CN1184227C (tr)
AR (1) AR016522A1 (tr)
AT (1) ATE227733T1 (tr)
AU (1) AU725506B2 (tr)
CA (1) CA2294928C (tr)
CZ (1) CZ296326B6 (tr)
DE (1) DE69809433T2 (tr)
DK (1) DK1001962T3 (tr)
ES (1) ES2182317T3 (tr)
HU (1) HUP0004631A3 (tr)
ID (1) ID24327A (tr)
IL (1) IL133558A0 (tr)
PL (1) PL188159B1 (tr)
PT (1) PT1001962E (tr)
RU (1) RU2211221C2 (tr)
TR (1) TR200000196T2 (tr)
WO (1) WO1999005156A1 (tr)
YU (1) YU71699A (tr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2723648A1 (en) 2008-04-10 2009-10-15 Piyush Gupta Methods for identification and use of agents targeting cancer stem cells
US10106778B2 (en) 2012-11-08 2018-10-23 Whitehead Institute For Biomedical Research Selective targeting of cancer stem cells
WO2015168255A1 (en) 2014-04-29 2015-11-05 Whitehead Institute For Biomedical Research Methods and compositions for targeting cancer stem cells
CN104430397B (zh) * 2014-11-06 2016-08-24 山东永泰化工有限公司 一种用于防治红蜘蛛的水分散粒剂
CN107021990B (zh) * 2017-06-14 2019-07-12 博瑞生物医药（苏州）股份有限公司 高纯度塞拉菌素的制备方法
CN107118247B (zh) * 2017-06-14 2019-07-26 博瑞生物医药（苏州）股份有限公司 塞拉菌素的制备方法
CN107188915B (zh) * 2017-07-19 2019-08-02 苏州正永生物医药有限公司 一种塞拉菌素中间体的制备方法
CN107723325B (zh) * 2017-11-28 2021-03-30 山东齐发药业有限公司 基于pH控制的多拉菌素发酵生产方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4328335A (en) 1979-08-13 1982-05-04 Merck & Co., Inc. Process for the interconversion of C-076 compounds
US5015630A (en) * 1989-01-19 1991-05-14 Merck & Co., Inc. 5-oxime avermectin derivatives
GB9205007D0 (en) * 1992-03-07 1992-04-22 Pfizer Ltd Antiparasitic agents
GB9402916D0 (en) * 1994-02-16 1994-04-06 Pfizer Ltd Antiparasitic agents
EP0676236A1 (en) * 1994-04-05 1995-10-11 Pfizer Inc. Process for removal of allyl group or allyloxycarbonyl group

Also Published As

Publication number Publication date
CZ200097A3 (cs) 2000-05-17
RU2211221C2 (ru) 2003-08-27
KR100339191B1 (ko) 2002-06-01
CA2294928C (en) 2003-01-14
HK1027110A1 (en) 2001-01-05
EP1001962A1 (en) 2000-05-24
ATE227733T1 (de) 2002-11-15
AR016522A1 (es) 2001-07-25
PL188159B1 (pl) 2004-12-31
DE69809433T2 (de) 2003-05-08
WO1999005156A1 (en) 1999-02-04
EP1001962B8 (en) 2003-03-05
ID24327A (id) 2000-07-13
EP1001962B1 (en) 2002-11-13
HUP0004631A2 (hu) 2001-05-28
DK1001962T3 (da) 2002-12-16
CZ296326B6 (cs) 2006-02-15
IL133558A0 (en) 2001-04-30
KR20010014066A (ko) 2001-02-26
AU725506B2 (en) 2000-10-12
PL338354A1 (en) 2000-10-23
HUP0004631A3 (en) 2002-11-28
CN1265113A (zh) 2000-08-30
YU71699A (sh) 2002-06-19
CN1184227C (zh) 2005-01-12
CA2294928A1 (en) 1999-02-04
JP3267634B2 (ja) 2002-03-18
PT1001962E (pt) 2003-01-31
AU7671498A (en) 1999-02-16
ES2182317T3 (es) 2003-03-01
DE69809433D1 (de) 2002-12-19
JP2000513385A (ja) 2000-10-10

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