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TR199903249T2 - Il-5 inhibitörleri olarak 6-Azaurasil türevleri. - Google Patents

Il-5 inhibitörleri olarak 6-Azaurasil türevleri.

Info

Publication number
TR199903249T2
TR199903249T2 TR1999/03249T TR9903249T TR199903249T2 TR 199903249 T2 TR199903249 T2 TR 199903249T2 TR 1999/03249 T TR1999/03249 T TR 1999/03249T TR 9903249 T TR9903249 T TR 9903249T TR 199903249 T2 TR199903249 T2 TR 199903249T2
Authority
TR
Turkey
Prior art keywords
6alkyl
aryl
formula
6alkyloxy
mono
Prior art date
Application number
TR1999/03249T
Other languages
English (en)
Inventor
Jean Edgard Freyne Eddy
Maria Boeckx Gustaaf
Pierre Frans Van Wauwe Jean
Stanislas Marcella Diels Gaston
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of TR199903249T2 publication Critical patent/TR199903249T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0461—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

(Formül(I)); Mevcut bulus, formül (I)'in bilesiklerinin kullanimi ile ilgilidir: N-oksitler, bunlarin farmasötik açidan kabul görür ilave tuzlari ve stereokimyasal izomer biçimleri, eosinofile bagli atesli hastaliklarin tedavisinde yararli olan bir ilacin üretiminde kullanimi ile ilgili olup, burada p 0, 1, 2 veya 3'ü; q 0, 1, 2, 3 veya 4'ü; R hidrojen, C1-6 alkil, mono- veya di(C1-6alkil)aminoC1-6alkiloksi, merkapto, C1-6alkiltiyo, C3-7sikloalkil, aril veya mono- veya di(C1-6alkil)amino ikameli C1-6alkil, C1-6alkiloksi, aril veya Het'i; R , -C(=X)-Y-R5 formülünün siyano veya bir radikalini, burada X, O veya S'i; Y, O, S, NR6 veya dogrudan bir bagi; R5; hidrojen, C1-6alkil, C3-7sikloalkil, aril veya ikameli C1-6 alkili temsil eder.
TR1999/03249T 1997-07-10 1998-07-02 Il-5 inhibitörleri olarak 6-Azaurasil türevleri. TR199903249T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97202117 1997-07-10

Publications (1)

Publication Number Publication Date
TR199903249T2 true TR199903249T2 (tr) 2000-09-21

Family

ID=8228530

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/03249T TR199903249T2 (tr) 1997-07-10 1998-07-02 Il-5 inhibitörleri olarak 6-Azaurasil türevleri.

Country Status (20)

Country Link
US (2) US6743792B2 (tr)
EP (1) EP1003729A1 (tr)
JP (1) JP2002508001A (tr)
KR (1) KR20010012614A (tr)
CN (1) CN1261881A (tr)
AU (1) AU756637B2 (tr)
BR (1) BR9811499A (tr)
CA (1) CA2294533A1 (tr)
EE (1) EE9900585A (tr)
HR (1) HRP990333A2 (tr)
HU (1) HUP0002826A3 (tr)
ID (1) ID24224A (tr)
IL (1) IL133915A0 (tr)
NO (1) NO20000094L (tr)
NZ (1) NZ501627A (tr)
PL (1) PL337875A1 (tr)
SK (1) SK180999A3 (tr)
TR (1) TR199903249T2 (tr)
WO (1) WO1999002504A1 (tr)
ZA (1) ZA986095B (tr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0987265A1 (en) * 1998-09-18 2000-03-22 Janssen Pharmaceutica N.V. Interleukin-5 inhibiting 6-azauracil derivatives
TR200101422T2 (tr) 1998-11-23 2001-10-22 Janssen Pharmaceutica N.V. IL-5 inhibe edici 6-azaurasil türevleri
SK8152001A3 (en) * 1998-12-18 2002-04-04 Janssen Pharmaceutica Nv Il-5 inhibiting 6-azauracil derivatives
CA2380759A1 (en) 1999-08-06 2001-02-15 Janssen Pharmaceutica N.V. Interleukin-5 inhibiting 6-azauracil derivatives
US8073380B2 (en) * 2005-12-30 2011-12-06 Nokia Corporation Media content delivery and recording over broadcast network
CN119161311B (zh) * 2024-11-20 2025-02-11 北京纳百生物科技有限公司 一种地克珠利抗原及其合成方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3883527A (en) 1973-10-19 1975-05-13 Pfizer Process for preparation of 2-aryl-1,3,4-triazine-3,5(2H,4H)-diones
US4631278A (en) * 1984-08-01 1986-12-23 Janssen Pharmaceutica N.V. Anti-protozoal α-aryl-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-benzeneacetonitrile derivatives, pharmaceutical compositions, and method of use therefor
GB8602342D0 (en) * 1986-01-30 1986-03-05 Janssen Pharmaceutica Nv 5 6-dihydro-2-(substituted phenyl)-1 2 4-triazine-3 5(2h 4h)-diones
CA1331757C (en) * 1988-02-29 1994-08-30 Janssen Pharmaceutica Naamloze Vennootschap 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
DE4120138A1 (de) * 1991-06-19 1992-12-24 Bayer Ag Substituierte hexahydro-1,2,4-triazindione, verfahren zu ihrer herstellung, zwischenprodukte dafuer und ihre verwendung
EP0476439A1 (de) * 1990-09-18 1992-03-25 Bayer Ag Substituierte 1,2,4-Triazindione, Verfahren zu ihrer Herstellung, Zwischenprodukte dafür und ihre Verwendung
TW263495B (tr) * 1992-12-23 1995-11-21 Celltech Ltd
GB9304920D0 (en) * 1993-03-10 1993-04-28 Celltech Ltd Chemical compounds
TW332201B (en) * 1995-04-06 1998-05-21 Janssen Pharmaceutica Nv 1,3-Dihydro-1-(phenylalkyl)-2H-imidazol-2-one derivatives
EP0737672B1 (en) * 1995-04-14 2001-10-04 Takeda Schering-Plough Animal Health K.K. Method of producing triazine derivatives

Also Published As

Publication number Publication date
US20020042416A1 (en) 2002-04-11
CN1261881A (zh) 2000-08-02
PL337875A1 (en) 2000-09-11
NO20000094L (no) 2000-03-08
ID24224A (id) 2000-07-13
EE9900585A (et) 2000-08-15
NO20000094D0 (no) 2000-01-07
US6951857B2 (en) 2005-10-04
AU8441398A (en) 1999-02-08
AU756637B2 (en) 2003-01-16
US6743792B2 (en) 2004-06-01
JP2002508001A (ja) 2002-03-12
CA2294533A1 (en) 1999-01-21
HUP0002826A3 (en) 2003-01-28
KR20010012614A (ko) 2001-02-15
EP1003729A1 (en) 2000-05-31
SK180999A3 (en) 2000-10-09
HUP0002826A2 (hu) 2001-04-28
NZ501627A (en) 2002-02-01
BR9811499A (pt) 2000-09-19
ZA986095B (en) 2000-01-10
IL133915A0 (en) 2001-04-30
HRP990333A2 (en) 2000-04-30
WO1999002504A1 (en) 1999-01-21
US20030220331A1 (en) 2003-11-27

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