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TNSN96083A1 - 5, 6-DIHYDRO-9H-PYRAZOLO (3,4-C) -1, 2, 4-TRIAZOLO ( 4,3-α ) PYRIDINES TRICYCLIQUES, PROCEDE POUR LEUR PREPARATION ET COMPOSITIONS LES CONTENANT - Google Patents

5, 6-DIHYDRO-9H-PYRAZOLO (3,4-C) -1, 2, 4-TRIAZOLO ( 4,3-α ) PYRIDINES TRICYCLIQUES, PROCEDE POUR LEUR PREPARATION ET COMPOSITIONS LES CONTENANT

Info

Publication number
TNSN96083A1
TNSN96083A1 TNTNSN96083A TNSN96083A TNSN96083A1 TN SN96083 A1 TNSN96083 A1 TN SN96083A1 TN TNSN96083 A TNTNSN96083 A TN TNSN96083A TN SN96083 A TNSN96083 A TN SN96083A TN SN96083 A1 TNSN96083 A1 TN SN96083A1
Authority
TN
Tunisia
Prior art keywords
compositions containing
triazolo
pyrazolo
dihydro
preparation
Prior art date
Application number
TNTNSN96083A
Other languages
English (en)
Inventor
Jacob Duplantier Allen
Cooper Kelvin
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of TNSN96083A1 publication Critical patent/TNSN96083A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'INVENTION CONCERNE UN COMPOSE DE FORMULE : DANS LAQUELLE R1, R2, R3, R9, R10 REPRESENTENT L'HYDROGENE OU DIVERS SUBSTITUANTS ORGANIQUES. CE COMPOSE EST UTILE DANS L’INHIBITION DE LA PDE DE TYPE IV ET DE LA PRODUCTION DU TNF. APPLICATION : TRAITEMENT DE MALADIES INFLAMMATOIRES AVEC DES COMPOSITIONS CONTENANT CE COMPOSE.
TNTNSN96083A 1995-06-06 1996-06-05 5, 6-DIHYDRO-9H-PYRAZOLO (3,4-C) -1, 2, 4-TRIAZOLO ( 4,3-α ) PYRIDINES TRICYCLIQUES, PROCEDE POUR LEUR PREPARATION ET COMPOSITIONS LES CONTENANT TNSN96083A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/IB1995/000429 WO1996039408A1 (fr) 1995-06-06 1995-06-06 5,6-DIHYDRO-9H-PYRAZOLO[3,4-c]-1,2-4-TRIAZOLO[4,3-α]PYRIDINES TRICYCLIQUES
CA002223624A CA2223624C (fr) 1995-06-06 1995-06-06 5,6-dihydro-9h-pyrazolo[3,4-c]-1,2-4-triazolo[4,3-.alpha.]pyridines tricycliques
HU9601541A HUP9601541A3 (en) 1995-06-06 1996-06-05 Tricyclic 5,6-dihydro-9h-pyrazolo[3,4-c]-1,2,4-triazolol[4,3-a]-pyridines and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
TNSN96083A1 true TNSN96083A1 (fr) 2005-03-15

Family

ID=89994031

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN96083A TNSN96083A1 (fr) 1995-06-06 1996-06-05 5, 6-DIHYDRO-9H-PYRAZOLO (3,4-C) -1, 2, 4-TRIAZOLO ( 4,3-α ) PYRIDINES TRICYCLIQUES, PROCEDE POUR LEUR PREPARATION ET COMPOSITIONS LES CONTENANT

Country Status (43)

Country Link
US (1) US6004974A (fr)
EP (1) EP0837860B1 (fr)
JP (1) JP3107827B2 (fr)
KR (2) KR100191972B1 (fr)
CN (1) CN1061044C (fr)
AP (1) AP609A (fr)
AR (1) AR002745A1 (fr)
AT (1) ATE214700T1 (fr)
AU (1) AU694871B2 (fr)
BG (1) BG62568B1 (fr)
BR (1) BR9602627A (fr)
CA (1) CA2223624C (fr)
CO (1) CO4700460A1 (fr)
CZ (1) CZ287251B6 (fr)
DE (1) DE69525978T2 (fr)
DK (1) DK0837860T3 (fr)
DZ (1) DZ2044A1 (fr)
ES (1) ES2172583T3 (fr)
FI (1) FI114097B (fr)
HR (1) HRP960268B1 (fr)
HU (1) HUP9601541A3 (fr)
IL (1) IL118485A (fr)
IS (1) IS1913B (fr)
LV (1) LV11620B (fr)
MA (1) MA23893A1 (fr)
MX (1) MX9709897A (fr)
MY (1) MY116527A (fr)
NO (1) NO306256B1 (fr)
NZ (1) NZ286734A (fr)
OA (1) OA10458A (fr)
PL (1) PL184195B1 (fr)
PT (1) PT837860E (fr)
RO (1) RO115881B1 (fr)
RU (1) RU2161158C2 (fr)
SA (1) SA96170065B1 (fr)
SG (1) SG54341A1 (fr)
SI (1) SI9600186A (fr)
SK (1) SK282167B6 (fr)
TN (1) TNSN96083A1 (fr)
TR (1) TR199600482A1 (fr)
TW (1) TW460469B (fr)
WO (1) WO1996039408A1 (fr)
YU (1) YU49346B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2792938B1 (fr) 1999-04-28 2001-07-06 Warner Lambert Co NOUVELLES 1-AMINO TRIAZOLO [4,3-a] QUINAZOLINE-5-ONES INHIBITRICES DE PHOSPHODIESTERASES IV
EP1380585B1 (fr) * 1999-04-30 2004-11-10 Pfizer Products Inc. Pyrazolopyridinone comme intermédiaire
US6326495B2 (en) 1999-04-30 2001-12-04 Pfizer Inc. Process for preparing 8-cyclopentyl-6-ethyl-3-[substituted]-5,8-dihydro-4H-1,2,3a,7,8-pentaaza-as-indacenes and intermediates useful therein
ATE320800T1 (de) 1999-08-21 2006-04-15 Altana Pharma Ag Synergistische kombination von roflumilast und salmeterol
CA2402384A1 (fr) 2000-03-16 2001-09-20 Inflazyme Pharmaceuticals Ltd. Inhibiteurs benzyles de pde4
DE60216588T2 (de) * 2001-05-25 2007-09-20 Boehringer Ingelheim Pharma Gmbh & Co. Kg Kombination eines pde4-inhibitors mit tiotropium zur behandlung obstruktiver atemwegserkrankungen
WO2002096463A1 (fr) * 2001-05-25 2002-12-05 Pfizer Inc. Combinaison d'un inhibiteur de pde4 et d'un agent anti-cholinergique destinee a traiter des maladies respiratoires obstructives
GB0122031D0 (en) * 2001-09-12 2001-10-31 Pfizer Ltd Use of pde4 inhibitors in a dry powder inhaler
GB0129395D0 (en) * 2001-12-07 2002-01-30 Pfizer Ltd Pharmaceutical combination
US20050107420A1 (en) * 2002-05-23 2005-05-19 Boehringe Ingelheim Pharma Gmbh & Co. Kg Combination of a PDE4 inhibitor and tiotropium or derivative thereof for treating obstructive airways and other inflammatory diseases
EP1624893A2 (fr) 2003-04-01 2006-02-15 Applied Research Systems ARS Holding N.V. Inhibiteurs de phosphodiesterases dans l'infecondite
WO2006075748A1 (fr) * 2005-01-17 2006-07-20 Santen Pharmaceutical Co., Ltd. Agent therapeutique pour maladie conjonctivale allergique
JP2009512676A (ja) 2005-10-19 2009-03-26 ランバクシー ラボラトリーズ リミテッド ムスカリン性受容体アンタゴニストの医薬組成物
SI2363130T1 (sl) 2006-07-05 2014-09-30 Takeda Gmbh Kombinacija inhibitorjev HMG-CoA reduktaze atorvastatina ali simvastatina z inhibitorjem fosfodiesteraze 4, kot je roflumilast, za zdravljenje vnetnih pljučnih bolezni
WO2010043676A1 (fr) * 2008-10-17 2010-04-22 Boehringer Ingelheim International Gmbh Tétra-aza-hétérocycles comme inhibiteur de phosphatidylinositol-3-kinases (pi3-kinases)
WO2011067145A1 (fr) 2009-12-04 2011-06-09 Nerviano Medical Sciences S.R.L. Dérivés de tricyclopyrazole
WO2013084182A1 (fr) 2011-12-08 2013-06-13 Glenmark Pharmaceuticals S.A. Composition pharmaceutique comprenant un inhibiteur de l'enzyme pde4 et un agent analgésique

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3697532A (en) * 1970-08-12 1972-10-10 Squibb & Sons Inc 5-methyldipyrazolo {8 3,4-b;3{40 ,4{40 -d{9 {0 pyridin-3(2h)-ones
EP0707585A1 (fr) * 1993-07-06 1996-04-24 Pfizer Inc. Tetrahydro pyrazolopyridines bicycliques
CA2143143A1 (fr) * 1994-03-08 1995-09-09 Toshihiko Tanaka Derives de la 3-phenylpyrrolidine

Also Published As

Publication number Publication date
ATE214700T1 (de) 2002-04-15
DK0837860T3 (da) 2002-05-27
SK71896A3 (en) 1997-05-07
PL314459A1 (en) 1996-12-09
AR002745A1 (es) 1998-04-29
CN1142499A (zh) 1997-02-12
KR970003440A (ko) 1997-01-28
ES2172583T3 (es) 2002-10-01
HU9601541D0 (en) 1996-07-29
AP9600806A0 (en) 1996-07-31
YU34696A (sh) 1999-07-28
TR199600482A1 (tr) 1997-03-21
AP609A (en) 1997-09-03
EP0837860B1 (fr) 2002-03-20
IS4350A (is) 1996-12-07
DE69525978D1 (de) 2002-04-25
PL184195B1 (pl) 2002-09-30
JP3107827B2 (ja) 2000-11-13
NZ286734A (en) 1998-02-26
NO962320L (no) 1996-12-09
BG100640A (bg) 1997-03-31
CA2223624C (fr) 2001-02-20
MA23893A1 (fr) 1996-12-31
NO306256B1 (no) 1999-10-11
FI974434A0 (fi) 1997-12-05
BG62568B1 (bg) 2000-02-29
BR9602627A (pt) 1998-09-01
JPH10510242A (ja) 1998-10-06
LV11620B (en) 1997-04-20
HUP9601541A2 (en) 1997-02-28
RU2161158C2 (ru) 2000-12-27
AU5477396A (en) 1996-12-19
US6004974A (en) 1999-12-21
CO4700460A1 (es) 1998-12-29
RO115881B1 (ro) 2000-07-28
IL118485A0 (en) 1996-09-12
HRP960268B1 (en) 2002-12-31
KR100225719B1 (en) 1999-10-15
SK282167B6 (sk) 2001-11-06
CZ287251B6 (en) 2000-10-11
IL118485A (en) 2000-02-17
TW460469B (en) 2001-10-21
CN1061044C (zh) 2001-01-24
OA10458A (en) 2002-03-27
DZ2044A1 (fr) 2002-07-21
NO962320D0 (no) 1996-06-05
EP0837860A1 (fr) 1998-04-29
MY116527A (en) 2004-02-28
FI974434L (fi) 1997-12-05
LV11620A (lv) 1996-12-20
CA2223624A1 (fr) 1996-12-12
WO1996039408A1 (fr) 1996-12-12
HUP9601541A3 (en) 1997-05-28
HRP960268A2 (en) 1997-08-31
PT837860E (pt) 2002-07-31
SA96170065B1 (ar) 2005-12-21
CZ162696A3 (en) 1997-01-15
KR100191972B1 (ko) 1999-06-15
AU694871B2 (en) 1998-07-30
IS1913B (is) 2004-02-03
FI114097B (fi) 2004-08-13
SI9600186A (en) 1997-04-30
YU49346B (sh) 2005-07-19
DE69525978T2 (de) 2002-12-19
SG54341A1 (en) 1998-11-16
MX9709897A (es) 1998-03-31

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