TN2011000199A1 - Sulfoximine-substituted anilinopyrimidine derivatives as cdk inhibitors, the production thereof, and use as medicine - Google Patents

Sulfoximine-substituted anilinopyrimidine derivatives as cdk inhibitors, the production thereof, and use as medicine

Info

Publication number: TN2011000199A1
Authority: TN; Tunisia
Prior art keywords: sulfoximine; medicine; production; cdk inhibitors; anilinopyrimidine derivatives
Prior art date: 2008-10-21

Application number

TN2011000199A

Other languages

English (en)

Inventor

Ulrich Lücking

Rolf Jautelat

Gerhard Siemeister

Julia Schulze

Philip Lienau

Original Assignee

Bayer Ip Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-10-21

Filing date

2011-04-20

Publication date

2012-12-17

2011-04-20 Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh

2012-12-17 Publication of TN2011000199A1 publication Critical patent/TN2011000199A1/fr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

TN2011000199A 2008-10-21 2011-04-20 Sulfoximine-substituted anilinopyrimidine derivatives as cdk inhibitors, the production thereof, and use as medicine TN2011000199A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP08167113A EP2179991A1 (fr)	2008-10-21	2008-10-21	Dérivés d'anilino-pyrimidine substitués par sulfoximine en tant qu'inhibiteurs de CDK, leur fabrication et leur utilisation en tant que médicaments
PCT/EP2009/007247 WO2010046035A1 (fr)	2008-10-21	2009-10-09	Dérivés d'anilino-pyrimidine à substitution sulfoximine en tant qu'inhibiteurs de cdk, leur préparation et leur utilisation comme médicaments

Publications (1)

Publication Number	Publication Date
TN2011000199A1 true TN2011000199A1 (en)	2012-12-17

Family

ID=40282208

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TN2011000199A TN2011000199A1 (en)	2008-10-21	2011-04-20	Sulfoximine-substituted anilinopyrimidine derivatives as cdk inhibitors, the production thereof, and use as medicine

Country Status (38)

Country	Link
US (1)	US8735412B2 (fr)
EP (2)	EP2179991A1 (fr)
JP (1)	JP5564054B2 (fr)
KR (1)	KR20110069115A (fr)
CN (1)	CN102197029B (fr)
AR (1)	AR074053A1 (fr)
AU (1)	AU2009306733C1 (fr)
BR (1)	BRPI0920112A2 (fr)
CA (1)	CA2739739C (fr)
CO (1)	CO6361926A2 (fr)
CR (1)	CR20110210A (fr)
CU (1)	CU24052B1 (fr)
CY (1)	CY1115590T1 (fr)
DK (1)	DK2350026T3 (fr)
DO (1)	DOP2011000107A (fr)
EA (1)	EA019230B1 (fr)
EC (1)	ECSP11010992A (fr)
ES (1)	ES2499028T3 (fr)
HN (1)	HN2011001019A (fr)
HR (1)	HRP20140830T1 (fr)
IL (1)	IL211713A (fr)
MA (1)	MA32723B1 (fr)
MX (1)	MX2011004238A (fr)
MY (1)	MY155230A (fr)
NZ (1)	NZ592314A (fr)
PA (1)	PA8846201A1 (fr)
PE (1)	PE20110546A1 (fr)
PL (1)	PL2350026T3 (fr)
PT (1)	PT2350026E (fr)
RS (1)	RS53523B1 (fr)
SA (1)	SA109300632B1 (fr)
SI (1)	SI2350026T1 (fr)
TN (1)	TN2011000199A1 (fr)
TW (2)	TWI458716B (fr)
UA (1)	UA103500C2 (fr)
UY (1)	UY32190A (fr)
WO (1)	WO2010046035A1 (fr)
ZA (1)	ZA201103727B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2464633A1 (fr)	2009-08-14	2012-06-20	Boehringer Ingelheim International GmbH	Préparation régiosélective de dérivés de 2-amino-5-trifluorométhylpyrimidine
US8933227B2 (en)	2009-08-14	2015-01-13	Boehringer Ingelheim International Gmbh	Selective synthesis of functionalized pyrimidines
DE102010014427A1 (de)	2010-04-01	2011-10-06	Bayer Schering Pharma Aktiengesellschaft	Kombinationen neuer pan-CDK-Inhibitoren zur Behandlung von Tumoren
DE102010014426A1 (de) *	2010-04-01	2011-10-06	Bayer Schering Pharma Aktiengesellschaft	Verwendung neuer pan-CDK-Inhibitoren zur Behandlung von Tumoren
DE102010046720A1 (de) *	2010-09-23	2012-03-29	Bayer Schering Pharma Aktiengesellschaft	Verfahren zur Herstellung von pan-CDK-Inhibitoren der Formel (l), sowie Intermediate der Herstellung
TWI555737B (zh)	2011-05-24	2016-11-01	拜耳知識產權公司	含有硫醯亞胺基團之４－芳基－ｎ－苯基－１，３，５－三氮雜苯－２－胺
DE102011080992A1 (de) *	2011-08-16	2013-02-21	Bayer Pharma AG	Verwendung von MAD2L2 als Stratifikationsmarker bei der Behandlung von Brusttumoren mit neuen pan-CDK-Inhibitoren
DE102011080991A1 (de) *	2011-08-16	2013-02-21	Bayer Pharma AG	Verwendung von CCNE2 als Stratifikationsmarker bei der Behandlung von Brusttumoren mit neuen pan-CDK-Inhibitoren
EP2755948B1 (fr)	2011-09-16	2016-05-25	Bayer Intellectual Property GmbH	Dérivés de 5-fluoropyrimidine disubstitués contenant un groupe sulfoximine
KR20140135215A (ko) *	2012-03-21	2014-11-25	바이엘 인텔렉쳐 프로퍼티 게엠베하	특정한 종양의 치료를 위한 (rs)-s-시클로프로필-s-(4-｛[4-｛[(1r, 2r)-2-히드록시-1-메틸프로필]옥시｝-5-(트리플루오로메틸)피리미딘-2-일]아미노｝페닐)술폭시미드의 용도
EP3207038B1 (fr) *	2014-10-16	2018-08-22	Bayer Pharma Aktiengesellschaft	Dérivés de benzofuranyle-pyrimidine fluorés contenant un groupe sulfoximine
HUE070338T2 (hu)	2018-09-10	2025-05-28	Mirati Therapeutics Inc	Kombinációs terápiák

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DE4029650A1 (de)	1990-09-19	1992-03-26	Hoechst Ag	2-anilino-pyrimidine, verfahren zu ihrer herstellung, sie enthaltene mittel und ihre verwendung als fungizide
JP2001509483A (ja)	1997-07-12	2001-07-24	カンサーリサーチキャンペーンテクノロジーリミテッド	サイクリン依存性キナーゼ阻害性プリン誘導体
US6440965B1 (en)	1997-10-15	2002-08-27	Krenitsky Pharmaceuticals, Inc.	Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system
EP1107958B1 (fr)	1998-08-29	2006-08-16	AstraZeneca AB	Composes pyrimidiniques
GB9828511D0 (en)	1998-12-24	1999-02-17	Zeneca Ltd	Chemical compounds
GB9919778D0 (en)	1999-08-21	1999-10-27	Zeneca Ltd	Chemical compounds
GB0016877D0 (en)	2000-07-11	2000-08-30	Astrazeneca Ab	Chemical compounds
JP4291135B2 (ja)	2001-05-29	2009-07-08	バイエル・シエーリング・ファーマアクチエンゲゼルシャフト	Ｃｄｋ阻害性ピリミジン、それらの製造および薬剤としての使用
EP1483260A1 (fr)	2002-03-11	2004-12-08	Schering Aktiengesellschaft	2-heteroaryle-pyrimidines inhibitrices de la kinase dependante des cyclines, leur production et leur utilisation comme medicaments
HRP20050601A2 (en)	2002-11-28	2005-10-31	Schering Ag	Chk-, pdk-, and akt-inhibitory pyrimidines, their production and use as pharmarmaceutical agents
DE10349423A1 (de)	2003-10-16	2005-06-16	Schering Ag	Sulfoximinsubstituierte Parimidine als CDK- und/oder VEGF-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
WO2006034872A1 (fr) *	2004-09-29	2006-04-06	Bayer Schering Pharma Aktiengesellschaft	2-anilinopyrimidine substituee utilisee en tant que kinase a cycle cellulaire ou recepteur de la tyrosine kinase, leur production et leur utilisation en tant que medicament
DE102005062742A1 (de)	2005-12-22	2007-06-28	Bayer Schering Pharma Ag	Sulfoximin substituierte Pyrimidine, Verfahren zu deren Herstellung und ihre Verwendung als Arzneimittel
DE102006027156A1 (de) *	2006-06-08	2007-12-13	Bayer Schering Pharma Ag	Sulfimide als Proteinkinaseinhibitoren
EP2179992A1 (fr) *	2008-10-21	2010-04-28	Bayer Schering Pharma Aktiengesellschaft	Dérivés d'anilino-pyrimidine substitués par sulfone en tant qu'inhibiteurs de CDK, leur fabrication et leur utilisation en tant que médicaments

2008
- 2008-10-21 EP EP08167113A patent/EP2179991A1/fr not_active Withdrawn
2009
- 2009-10-09 MX MX2011004238A patent/MX2011004238A/es active IP Right Grant
- 2009-10-09 JP JP2011532519A patent/JP5564054B2/ja not_active Expired - Fee Related
- 2009-10-09 EA EA201100623A patent/EA019230B1/ru not_active IP Right Cessation
- 2009-10-09 PE PE2011000917A patent/PE20110546A1/es not_active Application Discontinuation
- 2009-10-09 NZ NZ592314A patent/NZ592314A/xx not_active IP Right Cessation
- 2009-10-09 PL PL09778874T patent/PL2350026T3/pl unknown
- 2009-10-09 US US13/125,066 patent/US8735412B2/en not_active Expired - Fee Related
- 2009-10-09 ES ES09778874.9T patent/ES2499028T3/es active Active
- 2009-10-09 EP EP09778874.9A patent/EP2350026B1/fr active Active
- 2009-10-09 BR BRPI0920112A patent/BRPI0920112A2/pt not_active IP Right Cessation
- 2009-10-09 SI SI200931004T patent/SI2350026T1/sl unknown
- 2009-10-09 CN CN200980141978.7A patent/CN102197029B/zh not_active Expired - Fee Related
- 2009-10-09 MY MYPI2011001632A patent/MY155230A/en unknown
- 2009-10-09 AU AU2009306733A patent/AU2009306733C1/en not_active Ceased
- 2009-10-09 CA CA2739739A patent/CA2739739C/fr not_active Expired - Fee Related
- 2009-10-09 HR HRP20140830AT patent/HRP20140830T1/hr unknown
- 2009-10-09 WO PCT/EP2009/007247 patent/WO2010046035A1/fr active Application Filing
- 2009-10-09 UA UAA201106183A patent/UA103500C2/uk unknown
- 2009-10-09 KR KR1020117009024A patent/KR20110069115A/ko not_active Abandoned
- 2009-10-09 RS RSP20140466 patent/RS53523B1/en unknown
- 2009-10-09 DK DK09778874.9T patent/DK2350026T3/da active
- 2009-10-09 PT PT97788749T patent/PT2350026E/pt unknown
- 2009-10-19 PA PA20098846201A patent/PA8846201A1/es unknown
- 2009-10-20 UY UY0001032190A patent/UY32190A/es not_active Application Discontinuation
- 2009-10-20 SA SA109300632A patent/SA109300632B1/ar unknown
- 2009-10-21 TW TW098135674A patent/TWI458716B/zh not_active IP Right Cessation
- 2009-10-21 AR ARP090104043A patent/AR074053A1/es not_active Application Discontinuation
- 2009-10-21 TW TW103126302A patent/TWI496774B/zh not_active IP Right Cessation
2011
- 2011-03-14 IL IL211713A patent/IL211713A/en not_active IP Right Cessation
- 2011-04-15 HN HN2011001019A patent/HN2011001019A/es unknown
- 2011-04-20 CU CU2011000088A patent/CU24052B1/es active IP Right Grant
- 2011-04-20 DO DO2011000107A patent/DOP2011000107A/es unknown
- 2011-04-20 MA MA33786A patent/MA32723B1/fr unknown
- 2011-04-20 EC EC2011010992A patent/ECSP11010992A/es unknown
- 2011-04-20 TN TN2011000199A patent/TN2011000199A1/fr unknown
- 2011-04-20 CO CO11049624A patent/CO6361926A2/es active IP Right Grant
- 2011-04-25 CR CR20110210A patent/CR20110210A/es unknown
- 2011-05-20 ZA ZA2011/03727A patent/ZA201103727B/en unknown
2014
- 2014-09-05 CY CY20141100717T patent/CY1115590T1/el unknown

Also Published As

Publication number	Publication date
IL211713A (en)	2015-04-30
UA103500C2 (uk)	2013-10-25
UY32190A (es)	2010-05-31
AU2009306733C1 (en)	2016-07-14
EP2350026A1 (fr)	2011-08-03
CN102197029B (zh)	2014-05-14
HN2011001019A (es)	2013-07-01
HRP20140830T1 (hr)	2014-11-21
SI2350026T1 (sl)	2014-10-30
EA019230B1 (ru)	2014-02-28
IL211713A0 (en)	2011-06-30
ES2499028T3 (es)	2014-09-26
EP2179991A1 (fr)	2010-04-28
CA2739739C (fr)	2016-12-20
CU24052B1 (es)	2014-12-26
US8735412B2 (en)	2014-05-27
ZA201103727B (en)	2014-11-26
CA2739739A1 (fr)	2010-04-29
TWI496774B (zh)	2015-08-21
CO6361926A2 (es)	2012-01-20
TW201444803A (zh)	2014-12-01
JP5564054B2 (ja)	2014-07-30
DK2350026T3 (da)	2014-09-15
CU20110088A7 (es)	2011-12-28
PE20110546A1 (es)	2011-08-12
CN102197029A (zh)	2011-09-21
MX2011004238A (es)	2011-05-23
US20110294838A1 (en)	2011-12-01
KR20110069115A (ko)	2011-06-22
TW201020237A (en)	2010-06-01
MA32723B1 (fr)	2011-10-02
PL2350026T3 (pl)	2014-11-28
AU2009306733A1 (en)	2010-04-29
AU2009306733B2 (en)	2015-11-12
DOP2011000107A (es)	2011-05-15
SA109300632B1 (ar)	2013-07-04
EP2350026B1 (fr)	2014-06-18
BRPI0920112A2 (pt)	2015-12-22
PT2350026E (pt)	2014-09-12
PA8846201A1 (es)	2010-05-26
CY1115590T1 (el)	2017-01-04
WO2010046035A1 (fr)	2010-04-29
TWI458716B (zh)	2014-11-01
EA201100623A1 (ru)	2011-12-30
JP2012506391A (ja)	2012-03-15
AR074053A1 (es)	2010-12-22
ECSP11010992A (es)	2011-05-31
MY155230A (en)	2015-09-30
RS53523B1 (en)	2015-02-27
NZ592314A (en)	2013-02-22
CR20110210A (es)	2011-06-08

Publication	Publication Date	Title
TN2011000199A1 (en)	2012-12-17	Sulfoximine-substituted anilinopyrimidine derivatives as cdk inhibitors, the production thereof, and use as medicine
NZ601483A (en)	2013-10-25	Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
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ATE554076T1 (de)	2012-05-15	Sulfoximinsubstituierte chinazolinderivate als immunmodulatoren, ihre herstellung und ihre verwendung als medikamente
JO2682B1 (en)	2013-03-03	Derivatives of alkynil-8.1-naphthayridone, preparations thereof and therapeutic use thereof
WO2009074247A8 (fr)	2010-07-15	Nouveaux dérivés d'amide d'acide 2-arylthiazole-4-carboxylique, leur préparation et leur utilisation en tant que médicament
MX2011008662A (es)	2011-09-06	2-mercapto-3-aminopiridinas sustituidas como moduladores de kcnq2/3.
MX2011009338A (es)	2011-09-27	3-amino-2-mercaptoquinolinas sustituidas como moduladores de kcnq2/3.
WO2011009533A3 (fr)	2011-04-21	Dérivés 17-hydroxy-17-pentafluoroéthyl-estra-4,9(10)-diène-11-éthinylphényle, procédés de préparation et utilisation pour le traitement de maladies
MX2010002506A (es)	2010-03-26	Compuestos de nicotinamida sustituidos y uso de estos en medicamentos.
UA96951C2 (ru)	2011-12-26	ЭНАНТИОМЕРНОЧИСТЫЕ β-АГОНИСТЫ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ИХ ПРИМЕНЕНИЯ КАК ЛЕКАРСТВЕННЫХ СРЕДСТВ
PL1745010T3 (pl)	2010-01-29	Podstawione pochodne cykloheksylo-1,4-diaminy
MX2009007598A (es)	2009-07-27	Hexahidrato de enrofloxacino.
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