TN2010000060A1 - Proteasome inhibitors - Google Patents

Proteasome inhibitors

Info

Publication number: TN2010000060A1
Authority: TN; Tunisia
Prior art keywords: proteasome inhibitors; compositions; treatment; methods; various diseases
Prior art date: 2007-08-06

Application number

TNP2010000060A

Other languages

English (en)

Inventor

Edward J Olhava

Miheala D Danca

Original Assignee

Millennium Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-08-06

Filing date

2010-02-05

Publication date

2011-09-26

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38691782&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TN2010000060(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2010-02-05 Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc

2011-09-26 Publication of TN2010000060A1 publication Critical patent/TN2010000060A1/fr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Toxicology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Gastroenterology & Hepatology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

TNP2010000060A 2007-08-06 2010-02-05 Proteasome inhibitors TN2010000060A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US2007/017440 WO2009020448A1 (fr)	2007-08-06	2007-08-06	Inhibiteurs de protéasomes

Publications (1)

Publication Number	Publication Date
TN2010000060A1 true TN2010000060A1 (en)	2011-09-26

Family

ID=38691782

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TNP2010000060A TN2010000060A1 (en)	2007-08-06	2010-02-05	Proteasome inhibitors

Country Status (32)

Country	Link
EP (3)	EP2178888B1 (fr)
JP (1)	JP5261488B2 (fr)
KR (6)	KR20150010802A (fr)
CN (1)	CN101772507B (fr)
AU (1)	AU2007357338B2 (fr)
BR (1)	BRPI0721905B8 (fr)
CA (1)	CA2695082C (fr)
CY (2)	CY1113386T1 (fr)
DK (1)	DK2178888T3 (fr)
EA (1)	EA028622B1 (fr)
EC (1)	ECSP10010015A (fr)
ES (1)	ES2390606T3 (fr)
FR (1)	FR17C1011I2 (fr)
GE (1)	GEP20125599B (fr)
HR (1)	HRP20120745T1 (fr)
HU (1)	HUS1700018I1 (fr)
IL (4)	IL203641A (fr)
LT (1)	LTC2178888I2 (fr)
LU (1)	LUC00013I2 (fr)
MY (1)	MY161991A (fr)
NL (1)	NL300871I2 (fr)
NZ (1)	NZ582693A (fr)
PH (1)	PH12014500053B1 (fr)
PL (1)	PL2178888T3 (fr)
PT (1)	PT2178888E (fr)
RS (1)	RS52435B (fr)
SG (1)	SG10201508712QA (fr)
SI (1)	SI2178888T1 (fr)
TN (1)	TN2010000060A1 (fr)
UA (1)	UA97536C2 (fr)
WO (1)	WO2009020448A1 (fr)
ZA (1)	ZA201000348B (fr)

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US7576206B2 (en)	2003-08-14	2009-08-18	Cephalon, Inc.	Proteasome inhibitors and methods of using the same
US7468383B2 (en)	2005-02-11	2008-12-23	Cephalon, Inc.	Proteasome inhibitors and methods of using the same
CA2629084C (fr)	2005-11-09	2015-08-11	Proteolix, Inc.	Composes pour l'inhibition de l'activite similaire a la chymotrypsine du proteasome 20s
EP2041158B1 (fr)	2006-06-19	2013-04-17	Onyx Therapeutics, Inc.	Peptide epoxycetones destinees a l'inhibition de proteasome
US7442830B1 (en)	2007-08-06	2008-10-28	Millenium Pharmaceuticals, Inc.	Proteasome inhibitors
CA2701778C (fr)	2007-10-04	2018-09-11	Onyx Therapeutics, Inc.	Inhibiteurs de protease epoxy-cetone peptidique cristalline, et synthese de ceto-epoxydes d'acides amines
FI2318419T4 (fi)	2008-06-17	2025-01-29	Takeda Pharmaceuticals Co	Boronaattiesteriyhdisteitä ja niiden farmaseuttisia koostumuksia
AR075090A1 (es)	2008-09-29	2011-03-09	Millennium Pharm Inc	Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden.
KR20110073584A (ko)	2008-10-21	2011-06-29	오닉스 세라퓨틱스, 인크.	펩티드 에폭시케톤과의 병용 요법
AR075899A1 (es)	2009-03-20	2011-05-04	Onyx Therapeutics Inc	Tripeptidos epoxicetonas cristalinos inhibidores de proteasa
EP2498793B1 (fr)	2009-11-13	2019-07-10	Onyx Therapeutics, Inc.	Oprozomib pour l'utilsation dans la suppression des metastases
CA2785300A1 (fr)	2009-12-22	2011-07-21	Cephalon, Inc.	Inhibiteurs du proteasome et leurs procedes de preparation, d'epuration et d'utilisation
MX2012010017A (es)	2010-03-01	2012-10-01	Onyx Therapeutics Inc	Compuestos de para la inhibicion de inmunoproteasomas.
EA029521B1 (ru)	2010-03-31	2018-04-30	Милленниум Фармасьютикалз, Инк.	Производные 1-амино-2-циклопропилэтилбороновой кислоты
CA2833775A1 (fr) *	2011-06-22	2012-12-27	Cephalon, Inc.	Inhibiteurs du proteasome et leurs methodes de preparation, de purification et d'utilisation
JP6207509B2 (ja) *	2011-08-30	2017-10-04	トラスティーズオブタフツカレッジ	固形腫瘍を治療するためのｆａｐ活性化プロテアソーム阻害剤
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WO2013112601A1 (fr) *	2012-01-24	2013-08-01	Millennium Pharmaceuticals, Inc.	Méthodes de traitement du cancer
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CN109096370B (zh) *	2012-07-26	2022-03-18	圣特莱国际公司	多肽环氧酮化合物
JP2013006855A (ja) *	2012-09-03	2013-01-10	Millennium Pharmaceuticals Inc	プロテアソーム阻害剤
JP6018319B2 (ja) *	2012-12-03	2016-11-02	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	置換トリアゾールボロン酸化合物
JP2016531886A (ja) *	2013-10-03	2016-10-13	ミレニアムファーマシューティカルズ，インコーポレイテッドＭｉｌｌｅｎｎｉｕｍＰｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ．	全身性エリテマトーデス及び／または狼瘡腎炎の予防または治療のための方法
JP2017524652A (ja)	2014-05-20	2017-08-31	ミレニアムファーマシューティカルズ，インコーポレイテッドＭｉｌｌｅｎｎｉｕｍＰｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ．	一次癌療法後に使用するためのホウ素含有プロテアソーム阻害剤
EP4180041A1 (fr)	2014-08-07	2023-05-17	Mayo Foundation for Medical Education and Research	Composés et procédés pour le traitement du cancer
MA41555A (fr) *	2015-02-17	2017-12-26	Millennium Pharm Inc	Polythérapie pour le traitement du cancer
US10144761B2 (en)	2015-06-19	2018-12-04	Hanlin Scientific Inc.	Chiral specific boron-containing compounds and their use in treating cancer or amyloidosis
CN106608883A (zh) *	2015-10-21	2017-05-03	北京大学	蛋白酶体抑制剂mln9708的合成方法
WO2017198194A1 (fr) *	2016-05-19	2017-11-23	成都奥璟生物科技有限公司	Acide boronique et composé ester borate et ses applications
CN106008572B (zh) *	2016-05-23	2018-08-17	成都千禧莱医药科技有限公司	一类二肽硼酸化合物及制备方法和用途
CN109476637B (zh)	2016-06-21	2022-02-01	奥瑞恩眼科有限责任公司	杂环脯氨酰胺衍生物
US10526315B2 (en)	2016-06-21	2020-01-07	Orion Ophthalmology LLC	Carbocyclic prolinamide derivatives
CN108368134B (zh) *	2016-07-25	2019-06-14	深圳市塔吉瑞生物医药有限公司	一种取代的硼酸化合物及包含该化合物的药物组合物及其用途
CN108440583B (zh) *	2017-01-23	2020-12-04	成都奥璟生物科技有限公司	一种新的硼酸衍生物及其药物组合物
US11596629B2 (en)	2017-02-28	2023-03-07	Mayo Foundation For Medical Education And Research	Compounds and methods for treating cancer
CN108794516A (zh) *	2017-04-26	2018-11-13	上海时莱生物技术有限公司	硼酸和硼酸酯类化合物及其制备方法和用途
US11414437B2 (en)	2017-07-28	2022-08-16	Chengdu Origin Biotechnology Limited Company	Borate compound, and synthesis method therefor and uses thereof
WO2019038406A1 (fr)	2017-08-25	2019-02-28	Synthon B.V.	Procédé pour la préparation d'ixazomib ou de ses intermédiaires
JP2018024694A (ja) *	2017-10-03	2018-02-15	ミレニアムファーマシューティカルズ，インコーポレイテッドＭｉｌｌｅｎｎｉｕｍＰｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ．	プロテアソーム阻害剤
US11243207B2 (en)	2018-03-29	2022-02-08	Mayo Foundation For Medical Education And Research	Assessing and treating cancer
CN115403603A (zh) *	2018-09-14	2022-11-29	成都奥璟生物科技有限公司	一种硼酸酯类药物及其用途
CN110357787A (zh) *	2019-08-02	2019-10-22	苏州艾和医药科技有限公司	依沙佐米合成工艺研究
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2007
- 2007-08-06 KR KR1020157000064A patent/KR20150010802A/ko not_active Ceased
- 2007-08-06 EP EP07811087A patent/EP2178888B1/fr active Active
- 2007-08-06 AU AU2007357338A patent/AU2007357338B2/en active Active
- 2007-08-06 UA UAA201002409A patent/UA97536C2/ru unknown
- 2007-08-06 KR KR1020167008358A patent/KR20160040735A/ko not_active Ceased
- 2007-08-06 PL PL07811087T patent/PL2178888T3/pl unknown
- 2007-08-06 PT PT07811087T patent/PT2178888E/pt unknown
- 2007-08-06 JP JP2010519898A patent/JP5261488B2/ja active Active
- 2007-08-06 SI SI200731030T patent/SI2178888T1/sl unknown
- 2007-08-06 EP EP16201780.0A patent/EP3210987A1/fr active Pending
- 2007-08-06 KR KR1020107003809A patent/KR101474831B1/ko active Active
- 2007-08-06 CN CN2007801001423A patent/CN101772507B/zh active Active
- 2007-08-06 KR KR1020147007078A patent/KR20140042933A/ko not_active Abandoned
- 2007-08-06 KR KR1020147007077A patent/KR20140042932A/ko not_active Ceased
- 2007-08-06 WO PCT/US2007/017440 patent/WO2009020448A1/fr active Application Filing
- 2007-08-06 ES ES07811087T patent/ES2390606T3/es active Active
- 2007-08-06 BR BRPI0721905A patent/BRPI0721905B8/pt active IP Right Grant
- 2007-08-06 CA CA2695082A patent/CA2695082C/fr active Active
- 2007-08-06 EA EA201070247A patent/EA028622B1/ru not_active IP Right Cessation
- 2007-08-06 MY MYPI2010000270A patent/MY161991A/en unknown
- 2007-08-06 NZ NZ582693A patent/NZ582693A/en unknown
- 2007-08-06 RS RS20120405A patent/RS52435B/en unknown
- 2007-08-06 EP EP12171220A patent/EP2527347A1/fr not_active Withdrawn
- 2007-08-06 GE GEAP200711714A patent/GEP20125599B/en unknown
- 2007-08-06 DK DK07811087.1T patent/DK2178888T3/da active
- 2007-08-06 SG SG10201508712QA patent/SG10201508712QA/en unknown
- 2007-08-06 KR KR1020167036758A patent/KR101831674B1/ko active Active
- 2007-08-06 HR HRP20120745TT patent/HRP20120745T1/hr unknown
2010
- 2010-01-18 ZA ZA2010/00348A patent/ZA201000348B/en unknown
- 2010-02-01 IL IL203641A patent/IL203641A/en active Protection Beyond IP Right Term
- 2010-02-05 TN TNP2010000060A patent/TN2010000060A1/fr unknown
- 2010-03-04 EC EC2010010015A patent/ECSP10010015A/es unknown
2012
- 2012-09-17 CY CY20121100845T patent/CY1113386T1/el unknown
2014
- 2014-01-06 PH PH12014500053A patent/PH12014500053B1/en unknown
2015
- 2015-10-26 IL IL242291A patent/IL242291A/en active IP Right Grant
- 2015-10-26 IL IL242290A patent/IL242290A/en active IP Right Grant
- 2015-10-26 IL IL242292A patent/IL242292A/en active IP Right Grant
2017
- 2017-04-05 LU LU00013C patent/LUC00013I2/fr unknown
- 2017-04-06 LT LTPA2017010C patent/LTC2178888I2/lt unknown
- 2017-04-14 FR FR17C1011C patent/FR17C1011I2/fr active Active
- 2017-04-26 CY CY2017016C patent/CY2017016I2/el unknown
- 2017-05-03 HU HUS1700018C patent/HUS1700018I1/hu unknown
- 2017-05-05 NL NL300871C patent/NL300871I2/nl unknown

Also Published As

Publication number	Publication date
EP2178888B1 (fr)	2012-07-04
AU2007357338A1 (en)	2009-02-12
HRP20120745T1 (hr)	2012-10-31
FR17C1011I1 (fr)	2017-05-26
KR20160040735A (ko)	2016-04-14
AU2007357338B2 (en)	2014-03-20
IL242290A0 (en)	2015-11-30
CA2695082A1 (fr)	2009-02-12
JP2010535759A (ja)	2010-11-25
RS52435B (en)	2013-02-28
HK1182924A1 (zh)	2013-12-13
KR20170004031A (ko)	2017-01-10
KR101474831B1 (ko)	2014-12-19
PL2178888T3 (pl)	2012-11-30
IL242291A (en)	2017-12-31
KR20140042932A (ko)	2014-04-07
LUC00013I1 (fr)	2017-04-06
IL242292A0 (en)	2015-11-30
PH12014500053A1 (en)	2015-03-30
ES2390606T3 (es)	2012-11-14
EA028622B1 (ru)	2017-12-29
CN101772507B (zh)	2012-12-12
EP2527347A1 (fr)	2012-11-28
MY161991A (en)	2017-05-31
IL203641A (en)	2015-11-30
KR20150010802A (ko)	2015-01-28
BRPI0721905B1 (pt)	2020-11-17
IL242290A (en)	2017-12-31
IL242292A (en)	2017-12-31
DK2178888T3 (da)	2012-10-01
CY2017016I1 (el)	2017-07-12
EP3210987A1 (fr)	2017-08-30
BRPI0721905B8 (pt)	2021-05-25
EA201070247A1 (ru)	2010-06-30
LTC2178888I2 (lt)	2018-03-12
NZ582693A (en)	2012-01-12
CN101772507A (zh)	2010-07-07
LTPA2017010I1 (lt)	2017-05-10
SI2178888T1 (sl)	2012-11-30
KR20140042933A (ko)	2014-04-07
UA97536C2 (en)	2012-02-27
IL242291A0 (en)	2015-11-30
KR20100059811A (ko)	2010-06-04
LUC00013I2 (fr)	2017-06-19
ZA201000348B (en)	2011-03-30
HUS1700018I1 (hu)	2017-05-29
ECSP10010015A (es)	2010-04-30
SG10201508712QA (en)	2015-11-27
HK1143595A1 (en)	2011-01-07
PH12014500053B1 (en)	2015-03-30
EP2178888A1 (fr)	2010-04-28
PT2178888E (pt)	2012-10-04
CY2017016I2 (el)	2017-07-12
CA2695082C (fr)	2015-07-28
CY1113386T1 (el)	2016-06-22
JP5261488B2 (ja)	2013-08-14
KR101831674B1 (ko)	2018-02-23
BRPI0721905A2 (pt)	2014-02-25
WO2009020448A1 (fr)	2009-02-12
GEP20125599B (en)	2012-08-10
NL300871I2 (nl)	2017-12-07
FR17C1011I2 (fr)	2018-04-27

Publication	Publication Date	Title
PH12014500053A1 (en)	2015-03-30	Proteasome inhibitors
PH12015501193A1 (en)	2016-01-11	Boronate ester compounds and pharmaceutical compositions thereof
MY166653A (en)	2018-07-18	Derivatives of 1-amino-2-cyclobutylethylboronic acid
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