SU60090A1 - The method of preparation of a therapeutic drug containing hexamine and iodine - Google Patents

Description

The invention relates to a method for preparing a therapeutic preparation containing hexamine and iodine.

The proposed drug is intended as a medical preventive and therapeutic agent against influenza-related diseases.

In the composition of the proposed preparation, urotropine is introduced with a small dose of iodine dissolved in potassium iodide. The effect of hexamine, as well as small doses of iodine separately, in influenza diseases has been well established.

Since a mixture of an aqueous solution of urotropine with small doses of iodine is not a persistent preparation and iodine drops out of solution as a crystalline precipitate, in preparing the preparation using the proposed method, a small amount of some organic acid should be added as a stabilizer, for example salicylic acid, citric acid, etc. The acid introduced into the solution in an insignificant amount increases the concentration of hydrogen ions (pH of the solution). The solution remains clear and no precipitate is observed.

A chemical study of an aqueous solution of urotropine and small doses of iodine, with the addition of a small amount of acid, showed that the iodine in such a solution is in a free state, and jpot production does not decompose. As indicated above, iodine, which is located in a solution in the free state, acts in the same direction as urotropin.

An example. For the preparation of the preparation, the above components are taken in approximately the following amount: for 300 ml of distilled water, 0.01 g of pure freeze-dried iodine, 0.02 g of potassium iodide, 0.01 g of citric acid or other organic acid and 10.0 g are taken urotropin. Iodine is triturated with potassium iodide in a mortar with a small amount of water, and hexamine mixed with one acid or another is dissolved in the remaining amount of water and both solutions are drained.

The drug can be prepared in the form of drops of the same composition.

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moreover, small doses of iodine with potassium iodide are mixed with 40% m I P r e m eds and z o b r e e and u. aqueous solution of urotropin and or- i

ganic acid. The method of preparation

Finally, a drug can be a drug containing hexamine

prepared in the form of tablets with pre- and iodine in small doses, about tl and h with an addition to the same constituent part, and with the fact that as stable and 1 milk; n; o-go for the localization specialist; t organizes a and t.tistase shell acid, for example, limonostrostnaya moutha, salicylic, etc.