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SU479768A1 - The method of producing pyrimidine derivatives - Google Patents

The method of producing pyrimidine derivatives

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Publication number
SU479768A1
SU479768A1 SU1953849A SU1953849A SU479768A1 SU 479768 A1 SU479768 A1 SU 479768A1 SU 1953849 A SU1953849 A SU 1953849A SU 1953849 A SU1953849 A SU 1953849A SU 479768 A1 SU479768 A1 SU 479768A1
Authority
SU
USSR - Soviet Union
Prior art keywords
pyrimidine derivatives
producing pyrimidine
alkyl
producing
picrate
Prior art date
Application number
SU1953849A
Other languages
Russian (ru)
Inventor
Юлия Степановна Дольская
Original Assignee
Институт Органической Химии Им. Н.Д.Зелинского
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Институт Органической Химии Им. Н.Д.Зелинского filed Critical Институт Органической Химии Им. Н.Д.Зелинского
Priority to SU1953849A priority Critical patent/SU479768A1/en
Application granted granted Critical
Publication of SU479768A1 publication Critical patent/SU479768A1/en

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  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Description

пиримидин. Выход 24%, т. кип. 163-165° С; т. пл. пикрата 226° С.pyrimidine. Yield 24%, kp. 163-165 ° C; m.p. picrate 226 ° C.

Пример 2. 10 мл 30%-ного иминаExample 2. 10 ml of 30% imine

МеСН N-С-NMe2 проиускают над катаIIMeCH N-C-NMe2 is generated over Kata II

||

ОABOUT

лизатором в стандартных услови х. Катализатор обрабатывают 5 мл концентрированной серной кислоты, затем раствором едкого кали , отфильтровывают выиавшую соль, а из фильтрата экстрагируют целевой продукт. Н-Метилпиримидон-2 получают с выходом 35%; т. пл. пикрата 160° С.under standard conditions. The catalyst is treated with 5 ml of concentrated sulfuric acid, then with caustic potassium solution, the distilled salt is filtered off, and the target product is extracted from the filtrate. H-Methylpyrimidone-2 is obtained in a yield of 35%; m.p. picrate 160 ° C.

Пример 3. 10 Л1Л 30%-ного спиртовогоExample 3. 10 L1L 30% alcohol

О IIAbout II

раствора имина МеСН N C-МНСНгОН пропускают над катализатором при 400° С и выдел ют пиримидинон-2, как описано в примере 2. Выход 25%; т. пл. пикрата 198° С.an imine solution of MeCH N C-MHHNHON is passed over the catalyst at 400 ° C and pyrimidinone-2 is isolated as described in example 2. Yield 25%; m.p. picrate 198 ° C.

Предмет изобретени Subject invention

1. Способ получени  производных пиримидина общей формулы1. A process for the preparation of pyrimidine derivatives of the general formula

,,

II

RR

где R, RI и R,where R, RI and R,

атом водорода или алкил; X - группа С О или СН-алкил, отличающийс  тем, что, с целью упрощени  технологического процесса дегидроциклизации в присутствии алюмохромокалиевого катализатора при 350-400° С подвергают имины общей формулыa hydrogen atom or an alkyl; X is a C O or CH-alkyl group, characterized in that, in order to simplify the process, dehydrocyclization in the presence of an aluminum-chromium catalyst at 350-400 ° C is subjected to imines of the general formula

RCH NXN-CHgRRCH NXN-CHgR

RR

R - алкил,R is alkyl,

R - атом водорода или алкил;R is a hydrogen atom or an alkyl;

- атом водорода, оксигруппа, алкил - hydrogen atom, hydroxy group, alkyl

или алкилиден; Xимеет указанные выще значени .or alkylidene; It has the above values.

SU1953849A 1973-08-01 1973-08-01 The method of producing pyrimidine derivatives SU479768A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU1953849A SU479768A1 (en) 1973-08-01 1973-08-01 The method of producing pyrimidine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU1953849A SU479768A1 (en) 1973-08-01 1973-08-01 The method of producing pyrimidine derivatives

Publications (1)

Publication Number Publication Date
SU479768A1 true SU479768A1 (en) 1975-08-05

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
SU1953849A SU479768A1 (en) 1973-08-01 1973-08-01 The method of producing pyrimidine derivatives

Country Status (1)

Country Link
SU (1) SU479768A1 (en)

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