SU463675A1 - Method for producing β-phosphorylated nitroalkanols - Google Patents
Method for producing β-phosphorylated nitroalkanolsInfo
- Publication number
- SU463675A1 SU463675A1 SU1973460A SU1973460A SU463675A1 SU 463675 A1 SU463675 A1 SU 463675A1 SU 1973460 A SU1973460 A SU 1973460A SU 1973460 A SU1973460 A SU 1973460A SU 463675 A1 SU463675 A1 SU 463675A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- phosphorylated
- nitroalkanols
- producing
- calculated
- found
- Prior art date
Links
Description
щают методом пленочной разгонки в вакууме (0,015 мм рт. ст.). Температура спирали 210- 220°С. Выделено 19 г (66%) вещества; п 1,4629; df 1,3142; MRo: найдено 47,56, вычислено 47,85. Найдено, %: N 5.55, 5,73; Р 14,00, 14,28. СбНиНОбР. Вычислено, %: N 6,16; Р 13,65. Пример 2. Получение 1 -диэтоксифосфонил-З-нитробутанола-2 . Аналогично из 7 г нитроэтана, метилата натри , приготовленного из 0,11 г натри и 2,5 мл метанола, и 17,2 г диэтоксифосфонилуксусного альдегида выдел ют 15 г (60% теории ) вещества, очищенного методом пленочной разгонки в вакууме (0,015 мм рт. ст.). Температура спирали 220°С; 1,4570; df 1,2134; MRo: найдено 57,23, вычислено 57,08. Найдено, %: N 5,86, 5,76; Р 12,63, 12,82. CsHisNOeP. Вычислено, %: N 5,49; Р 12,15. Структура продуктов подтверждена ИК- и ПМР-спектрами. ИК-спектр: 3250-3264 см- (ОН) 1548- 1546, 13;9 |-13 93fcM-r(NO2), 1220-1226 см (),Ш32-102§см- (РОС). ПМР-спектр: 6oii-5,65 м. д., SCHNO - 2,60 м. д. Предмет изобретени Способ получени ip-фосфорилированных нитроалканолов общей формулы . FCHjCHOHCHNO R О где R - OAlk, R - OAlk, Alk, R -Alk, отличающийс тем, что фосфорилированные альдегиды подвергают взаимодействию с нитропар1афина.ми в присутствии метилата натри в -качестве катализатора с последующим выделением целевого продукта известными приемами.Schut method of film distillation in vacuum (0.015 mm Hg. Art.). The temperature of the coil is 210-220 ° C. 19 g (66%) of the substance were isolated; p 1.4629; df 1.3142; MRo: found 47.56, calculated 47.85. Found,%: N 5.55, 5.73; R 14.00, 14.28. Sbnib. Calculated,%: N 6,16; P 13.65. Example 2. Getting 1-diethoxyphosphonyl-Z-nitrobutanol-2. Similarly, 15 g (60% of the theory) of the substance purified by film distillation in vacuum (0.015 mm Hg. Art.). The temperature of the coil is 220 ° C; 1.4570; df 1.2134; MRo: found 57.23, calculated 57.08. Found,%: N 5.86, 5.76; R 12.63, 12.82. CsHisNOeP. Calculated,%: N 5.49; R 12.15. The structure of the products is confirmed by IR and PMR spectra. IR spectrum: 3250-3264 cm- (OH) 1548- 1546, 13; 9 | -13 93fcM-r (NO2), 1220-1226 cm (), W32-102§cm- (ROS) PMR spectrum: 6oii-5.65 ppm, SCHNO - 2.60 ppm. Subject of the invention. Method for preparing ip-phosphorylated nitroalkanols of general formula. FCHjCHOHCHNO R O where R is OAlk, R is OAlk, Alk, R -Alk, characterized in that phosphorylated aldehydes are reacted with nitro-paraffin in the presence of sodium methoxide as the catalyst, followed by separation of the target product by known methods.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU1973460A SU463675A1 (en) | 1973-12-04 | 1973-12-04 | Method for producing β-phosphorylated nitroalkanols |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU1973460A SU463675A1 (en) | 1973-12-04 | 1973-12-04 | Method for producing β-phosphorylated nitroalkanols |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU463675A1 true SU463675A1 (en) | 1975-03-15 |
Family
ID=20568600
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1973460A SU463675A1 (en) | 1973-12-04 | 1973-12-04 | Method for producing β-phosphorylated nitroalkanols |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU463675A1 (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4772738A (en) * | 1984-10-12 | 1988-09-20 | Ciba-Geigy Corporation | Substituted propane-phosphonuous acid compounds |
| US5190933A (en) * | 1987-12-04 | 1993-03-02 | Ciba-Geigy Corporation | Substituted propane-phosphinic acid compounds |
| US5190934A (en) * | 1989-06-03 | 1993-03-02 | Ciba-Geigy Corporation | P-subsituted propane-phosphinic acid compounds |
| US5243062A (en) * | 1984-10-12 | 1993-09-07 | Ciba-Geigy Corporation | Substituted propane-phosphonous acid compounds |
| US5300679A (en) * | 1987-12-04 | 1994-04-05 | Ciba-Geigy Corporation | Substituted propane-phosphinic acid compounds |
| US5457095A (en) * | 1984-10-12 | 1995-10-10 | Ciba-Geigy Corporation | Substituted propane-phosponous acid compounds |
| US5461040A (en) * | 1989-05-13 | 1995-10-24 | Ciba-Geigy Corporation | Substituted aminoalkylphosphinic acids |
| US5545631A (en) * | 1990-06-22 | 1996-08-13 | Ciba-Geigy Corporation | N-substituted aminoalkanephosphinic acid derivatives, compositions thereof, and their use as anti-epileptics |
-
1973
- 1973-12-04 SU SU1973460A patent/SU463675A1/en active
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4772738A (en) * | 1984-10-12 | 1988-09-20 | Ciba-Geigy Corporation | Substituted propane-phosphonuous acid compounds |
| US4908465A (en) * | 1984-10-12 | 1990-03-13 | Ciba-Geigy Corporation | Substituted propane-phosphonous acid compounds |
| US5243062A (en) * | 1984-10-12 | 1993-09-07 | Ciba-Geigy Corporation | Substituted propane-phosphonous acid compounds |
| US5457095A (en) * | 1984-10-12 | 1995-10-10 | Ciba-Geigy Corporation | Substituted propane-phosponous acid compounds |
| US5190933A (en) * | 1987-12-04 | 1993-03-02 | Ciba-Geigy Corporation | Substituted propane-phosphinic acid compounds |
| US5300679A (en) * | 1987-12-04 | 1994-04-05 | Ciba-Geigy Corporation | Substituted propane-phosphinic acid compounds |
| US5461040A (en) * | 1989-05-13 | 1995-10-24 | Ciba-Geigy Corporation | Substituted aminoalkylphosphinic acids |
| US5190934A (en) * | 1989-06-03 | 1993-03-02 | Ciba-Geigy Corporation | P-subsituted propane-phosphinic acid compounds |
| US5545631A (en) * | 1990-06-22 | 1996-08-13 | Ciba-Geigy Corporation | N-substituted aminoalkanephosphinic acid derivatives, compositions thereof, and their use as anti-epileptics |
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