SU184860A1 - Method of producing n-dialkylphosphine-2-amidoethylpyridine - Google Patents
Method of producing n-dialkylphosphine-2-amidoethylpyridineInfo
- Publication number
- SU184860A1 SU184860A1 SU947278A SU947278A SU184860A1 SU 184860 A1 SU184860 A1 SU 184860A1 SU 947278 A SU947278 A SU 947278A SU 947278 A SU947278 A SU 947278A SU 184860 A1 SU184860 A1 SU 184860A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- amidoethylpyridine
- dialkylphosphine
- producing
- acetic acid
- pyridylethylamide
- Prior art date
Links
- 238000000034 method Methods 0.000 title description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 235000021317 phosphate Nutrition 0.000 description 2
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 2
- 239000013543 active substance Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Description
Предложен способ получени N-дналкилфосфинил-2-амидоэтилпиридинов . Полученные соединени могут быть использованы в качестве физиологически активных веществ. Предлагаемый способ состоит в том, что триалкил-Ы-2-пиридилэтилимидофосфаты подвергают взаимодействию с уксусной кислотой при нагревании. Пример. К раствору 0,10 г-моль трипропил-М-2-пиридилэтилимидофосфата в 15 мл Н-диалкилфосфинил-2-амидоэтилпиридинA process for the preparation of N-dinalkylphosphinyl-2-amidoethylpyridines has been proposed. The compounds obtained can be used as physiologically active substances. The proposed method consists in the fact that trialkyl-N-2-pyridylethylamide phosphates are reacted with acetic acid under heating. Example. To a solution of 0.10 gm of tripropyl-M-2-pyridylethylimidophosphate in 15 ml of N-dialkylphosphinyl-2-amidoethylpyridine
Предмет изобретени Subject invention
трналкил-М-2-пиридилэтилимидофосфаты под1;ергают взаимодействию с уксусной кислотой при нагревании. сухого бензола прибавл ют 0,10 г-ло.46лед ной уксусной кислоты. Реакционна смесь нагреваетс на кип ш,ей вод ной бане в течение 3 час. Затем отгон ютс в вакууме (30 мм рг. ст.} растворитель и легколетучие продукты . Полученный М-дипропилфосфинил-2амидоэтилпиридин представл ет собой желтую в зкую жидкость. Выход 96,5о/о; 112° 1,482; 1,1042. Свойства соединений, полученных по аналогичной методике, представлены в таблице. па il I CH.,CH,NHP/trnalkyl-M-2-pyridylethylamide phosphates under 1; they react with acetic acid when heated. dry benzene was added 0.10 g-4 .6 acetic acid. The reaction mixture was heated in a boiling water bath for 3 hours. Then, the solvent and volatile products are distilled off under vacuum (30 mm of the prop. Art.}. The obtained M-dipropylphosphinyl-2 amidoethylpyridine is a yellow viscous liquid. The yield is 96.5 ° C; 112 ° 1.482; 1.1042. The properties of the compounds obtained by a similar method, are presented in table. pas il I CH., CH, NHP /
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SU184859A1 SU184859A1 (en) | |
| SU184860A1 true SU184860A1 (en) |
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