SU136852A1 - The method of obtaining injection solutions of indigo carmine - Google Patents
The method of obtaining injection solutions of indigo carmineInfo
- Publication number
- SU136852A1 SU136852A1 SU654620A SU654620A SU136852A1 SU 136852 A1 SU136852 A1 SU 136852A1 SU 654620 A SU654620 A SU 654620A SU 654620 A SU654620 A SU 654620A SU 136852 A1 SU136852 A1 SU 136852A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- indigo carmine
- injection solutions
- obtaining injection
- solution
- obtaining
- Prior art date
Links
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Изобретение касаетс способов получени инъекционных растворов индигокармина с добавлением стабилизирующих веществ.The invention relates to methods for producing injection solutions of indigo carmine with the addition of stabilizing substances.
При применении известных сиособов дл приготовлени инъекционных растворов нельз использовать сухой индигокармин, хранившийс s течение длительного времени. Кроме того, использу известный метод, ампулы с раствором приходитс запаивать под вакуумом, дл чего требуетс специальна аппаратура.When using the known methods for preparing injection solutions, it is impossible to use dry indigo carmine stored for a long time. In addition, using the well-known method, ampoules with a solution must be sealed under vacuum, for which special equipment is required.
В описываемом способе указанные недостатки исключаютс тем, что в качестве стабилизаторов используетс ронгалит и лимоннокислый натрий .In the described method, these disadvantages are excluded by the use of rongalite and sodium citrate as stabilizers.
Собственно стабилизатором вл етс ронгалит, добавл емый при приготовлении ампул с 0,4%-ным раствором индигокармина в количестве 0,05%. Однако раствор ронгалита устойчив лишь при значени х , поэтому дл создани необходимой концентрации водоро ;ных ионов в раствор в качестве буфера добавл етс лимоннокислый натрий в количестве 0,1%,The stabilizer itself is rongalite added during the preparation of ampoules with a 0.4% solution of indigo carmine in an amount of 0.05%. However, the rongalite solution is stable only at values, therefore, in order to create the necessary concentration of hydrogen ions, sodium citrate is added to the solution in an amount of 0.1%,
Полученный по описываемому способу 0,4%-кый инъекционный раствор индигокармина не дает осадка при хранении его в течение полутора лет при комнатной температуре и в течение шести мес цев при температуре 75°.The 0.4% injectable solution of indigo carmine obtained by the described method does not precipitate during storage for one and a half years at room temperature and for six months at a temperature of 75 °.
Предмет изобретени Subject invention
Способ получени инъекционных растворов индигокармина с добавлением стабилизирующих веществ, от л и ч а ю щи и с тем, что, с целью применени сухого индигокармина различных сроков хранени и исключени запайки ампул под вакуумом, используют в качестве стабилизаторов ронгалит и лимоннокисль1Й нагрий.The method of obtaining injectable solutions of indigo carmine with the addition of stabilizing substances, from l and h and with the fact that, in order to use dry indigo carmine of various storage times and eliminate sealing of ampoules under vacuum, rongalite and citric acid heating are used as stabilizers.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU654620A SU136852A1 (en) | 1960-02-15 | 1960-02-15 | The method of obtaining injection solutions of indigo carmine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU654620A SU136852A1 (en) | 1960-02-15 | 1960-02-15 | The method of obtaining injection solutions of indigo carmine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU136852A1 true SU136852A1 (en) | 1960-11-30 |
Family
ID=48293099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU654620A SU136852A1 (en) | 1960-02-15 | 1960-02-15 | The method of obtaining injection solutions of indigo carmine |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU136852A1 (en) |
-
1960
- 1960-02-15 SU SU654620A patent/SU136852A1/en active
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