SMT202300372T1 - Virus adeno-associati varianti e metodi d'uso. - Google Patents
Virus adeno-associati varianti e metodi d'uso.Info
- Publication number
- SMT202300372T1 SMT202300372T1 SM20230372T SMT202300372T SMT202300372T1 SM T202300372 T1 SMT202300372 T1 SM T202300372T1 SM 20230372 T SM20230372 T SM 20230372T SM T202300372 T SMT202300372 T SM T202300372T SM T202300372 T1 SMT202300372 T1 SM T202300372T1
- Authority
- SM
- San Marino
- Prior art keywords
- methods
- associated viruses
- variant adeno
- adeno
- variant
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/01—DNA viruses
- C07K14/015—Parvoviridae, e.g. feline panleukopenia virus, human parvovirus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/06—Methods of screening libraries by measuring effects on living organisms, tissues or cells
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
- C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14145—Special targeting system for viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
- C12N2810/6027—Vectors comprising as targeting moiety peptide derived from defined protein from viruses ssDNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662350361P | 2016-06-15 | 2016-06-15 | |
US201662404585P | 2016-10-05 | 2016-10-05 | |
EP17734575.8A EP3472183B1 (en) | 2016-06-15 | 2017-06-15 | Variant adeno-associated viruses and methods of using |
PCT/US2017/037781 WO2017218842A1 (en) | 2016-06-15 | 2017-06-15 | Variant adeno-associated viruses and methods of using |
Publications (1)
Publication Number | Publication Date |
---|---|
SMT202300372T1 true SMT202300372T1 (it) | 2023-11-13 |
Family
ID=59258370
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SM20230372T SMT202300372T1 (it) | 2016-06-15 | 2017-06-15 | Virus adeno-associati varianti e metodi d'uso. |
Country Status (28)
Country | Link |
---|---|
US (2) | US10961282B2 (it) |
EP (2) | EP4268852A3 (it) |
JP (2) | JP7094277B2 (it) |
KR (2) | KR20230054754A (it) |
CN (2) | CN116003532A (it) |
AU (2) | AU2017286652B2 (it) |
BR (1) | BR112018076090A2 (it) |
CA (1) | CA3028113A1 (it) |
DK (1) | DK3472183T5 (it) |
EA (1) | EA201990033A1 (it) |
ES (1) | ES2962611T3 (it) |
FI (1) | FI3472183T3 (it) |
HR (1) | HRP20231403T1 (it) |
HU (1) | HUE063755T2 (it) |
IL (2) | IL263719B2 (it) |
LT (1) | LT3472183T (it) |
MA (1) | MA44546B1 (it) |
MX (2) | MX2018015770A (it) |
MY (1) | MY190221A (it) |
PH (1) | PH12018502664A1 (it) |
PL (1) | PL3472183T3 (it) |
PT (1) | PT3472183T (it) |
RS (1) | RS64769B1 (it) |
SG (1) | SG11201811189RA (it) |
SI (1) | SI3472183T1 (it) |
SM (1) | SMT202300372T1 (it) |
WO (1) | WO2017218842A1 (it) |
ZA (1) | ZA201900278B (it) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUE049629T2 (hu) * | 2011-04-22 | 2020-09-28 | Univ California | Adeno-asszociált vírus virionok kapszid variánssal és eljárások alkalmazásukra |
ES2897508T3 (es) | 2013-05-31 | 2022-03-01 | Univ California | Variantes de virus adenoasociados y métodos de uso de las mismas |
MX2018013463A (es) * | 2016-05-13 | 2019-07-04 | 4D Molecular Therapeutics Inc | Capsides variantes de virus adenoasociados y metodos de uso de las mismas. |
MA44546B1 (fr) | 2016-06-15 | 2021-03-31 | Univ California | Virus adéno-associés variants et procédés d'utilisation |
KR102508820B1 (ko) | 2016-07-29 | 2023-03-13 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 변이체 캡시드를 갖는 아데노-관련된 바이러스 비리온 및 이의 사용 방법 |
KR20200039617A (ko) | 2017-08-28 | 2020-04-16 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 아데노-연관 바이러스 캡시드 변이체 및 이의 사용 방법 |
JP7303816B2 (ja) * | 2017-10-16 | 2023-07-05 | ビゲネロン ゲゼルシャフト ミット ベシュレンクテル ハフツング | Aavベクター |
MX2021001336A (es) * | 2018-07-31 | 2021-09-10 | Univ Cornell | Métodos de terapia génica para controlar la función de órganos. |
EP3856913A4 (en) | 2018-09-26 | 2022-10-26 | California Institute Of Technology | Adeno-associated virus compositions for targeted gene therapy |
WO2021022208A1 (en) * | 2019-08-01 | 2021-02-04 | Kaplitt Michael G | Targeted gene therapy to treat neurological diseases |
US20230265453A1 (en) * | 2020-07-08 | 2023-08-24 | Baylor College Of Medicine | Gene therapy for stxbp1 encephalopathy |
CN111825772B (zh) * | 2020-07-30 | 2023-10-20 | 中国科学院精密测量科学与技术创新研究院 | 具有变异衣壳蛋白的腺相关病毒及其应用 |
MX2023000968A (es) | 2020-08-06 | 2023-03-01 | Fundacion Para La Investig Medica Aplicada | Particulas virales para usarse en el tratamiento contra tauopatias tales como enfermedad de alzheimer mediante terapia genica. |
EP4263575A1 (en) * | 2020-12-16 | 2023-10-25 | Children's Medical Research Institute | Adeno-associated virus capsids and vectors |
WO2022126188A1 (en) * | 2020-12-16 | 2022-06-23 | Children's Medical Research Institute | Aav capsids and vectors |
BR112023026523A2 (pt) | 2021-06-17 | 2024-03-05 | Meiragtx Uk Ii Ltd | Métodos para fabricar aav |
WO2023288184A2 (en) * | 2021-07-14 | 2023-01-19 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for treating chronic pain and for retrograde transduction of neurons |
CA3225084A1 (en) | 2021-07-14 | 2023-01-19 | MEIRAGTX, UK II Limited | Retgc gene therapy |
KR20240052746A (ko) | 2021-07-14 | 2024-04-23 | 메이라지티엑스 유케이 Ii 리미티드 | Kcnv2 유전자 요법 |
JP2025500874A (ja) | 2021-12-15 | 2025-01-15 | メイラグティーエックス ユーケー アイアイ リミティド | 消化管ペプチドのポリシストロニック発現 |
TW202346600A (zh) * | 2022-03-30 | 2023-12-01 | 高等教育聯邦系統 匹茲堡大學 | 用於將核酸遞送至視網膜神經節細胞和/或視網膜色素上皮細胞的腺相關病毒載體 |
WO2024059667A2 (en) * | 2022-09-13 | 2024-03-21 | Dyno Therapeutics, Inc. | Capsid variants and methods of using the same |
WO2024056902A2 (en) | 2022-09-16 | 2024-03-21 | Christopher Shaw | Compositions and methods for treating neurological diseases |
WO2024079657A1 (en) | 2022-10-11 | 2024-04-18 | Meiragtx Uk Ii Limited | Formulations for aav gene therapy |
WO2024079665A1 (en) | 2022-10-11 | 2024-04-18 | Meiragtx Uk Ii Limited | Nucleic acid regulatory elements for constitutive gene expression and methods of use |
WO2024079662A1 (en) | 2022-10-11 | 2024-04-18 | Meiragtx Uk Ii Limited | Upf1 expression constructs |
WO2024079661A1 (en) | 2022-10-11 | 2024-04-18 | Meiragtx Uk Ii Limited | Atp7b gene therapy |
WO2024079655A1 (en) | 2022-10-11 | 2024-04-18 | Meiragtx Uk Ii Limited | Chromatography methods for purification of aav capsids |
WO2024126696A1 (en) | 2022-12-14 | 2024-06-20 | King's College London | Compositions and methods for treating neurological diseases |
WO2024148189A2 (en) * | 2023-01-05 | 2024-07-11 | Emugen Therapeutics Llc | Neuronal promoters and uses thereof |
WO2024148179A2 (en) * | 2023-01-05 | 2024-07-11 | Emugen Therapeutics Llc | Retro-aav and use in treating neurodegenerative diseases |
WO2024161022A2 (en) | 2023-02-03 | 2024-08-08 | King's College London | Compositions and methods for treating neurological diseases |
WO2024213660A1 (en) | 2023-04-13 | 2024-10-17 | Meiragtx Uk Ii Limited | Inflammation-inducible promoters |
WO2024220316A1 (en) * | 2023-04-18 | 2024-10-24 | University Of Massachusetts | Capsid variants and uses thereof |
WO2024252182A1 (en) | 2023-06-08 | 2024-12-12 | Meiragtx Uk Ii Limited | Cation exchange chromatography for aav capture |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6156303A (en) | 1997-06-11 | 2000-12-05 | University Of Washington | Adeno-associated virus (AAV) isolates and AAV vectors derived therefrom |
US9233131B2 (en) * | 2003-06-30 | 2016-01-12 | The Regents Of The University Of California | Mutant adeno-associated virus virions and methods of use thereof |
WO2006119150A2 (en) * | 2005-04-29 | 2006-11-09 | Beth Israel Deaconess Medical Center | Compositions and methods for targeting of viral vectors |
WO2009108274A2 (en) | 2008-02-26 | 2009-09-03 | The University Of North Carolina At Chapel Hill | Methods and compositions for adeno-associated virus (aav) with hi loop mutations |
EP2396343B1 (en) | 2009-02-11 | 2017-05-17 | The University of North Carolina At Chapel Hill | Modified virus vectors and methods of making and using the same |
HUE049629T2 (hu) * | 2011-04-22 | 2020-09-28 | Univ California | Adeno-asszociált vírus virionok kapszid variánssal és eljárások alkalmazásukra |
US9719992B2 (en) | 2011-10-07 | 2017-08-01 | Howard Hughes Medical Institute | Genetically encoded biosensors |
WO2013174760A1 (en) | 2012-05-25 | 2013-11-28 | Deutsches Krebsforschungszentrum | Optimized aav-vectors for high transduction rates in dendritic cells |
US9518980B2 (en) | 2012-10-10 | 2016-12-13 | Howard Hughes Medical Institute | Genetically encoded calcium indicators |
US9518996B2 (en) | 2013-08-05 | 2016-12-13 | Howard Hughes Medical Institute | Fluorescent protein-based calcium integrators |
ES2739288T3 (es) * | 2013-09-13 | 2020-01-30 | California Inst Of Techn | Recuperación selectiva |
CN104592364B (zh) * | 2013-10-30 | 2018-05-01 | 北京大学 | 定点突变和定点修饰的腺相关病毒、其制备方法及应用 |
GB201403684D0 (en) * | 2014-03-03 | 2014-04-16 | King S College London | Vector |
US10746742B2 (en) * | 2014-04-25 | 2020-08-18 | Oregon Health & Science University | Methods of viral neutralizing antibody epitope mapping |
US10370432B2 (en) | 2014-10-03 | 2019-08-06 | University Of Massachusetts | Heterologous targeting peptide grafted AAVS |
JP2017536116A (ja) * | 2014-11-21 | 2017-12-07 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 中枢神経系を標的化したaavベクター |
US9644007B2 (en) | 2014-12-23 | 2017-05-09 | Howard Hughes Medical Institute | Red genetically encoded calcium indicators and methods of use |
MX2018013463A (es) | 2016-05-13 | 2019-07-04 | 4D Molecular Therapeutics Inc | Capsides variantes de virus adenoasociados y metodos de uso de las mismas. |
MA44546B1 (fr) | 2016-06-15 | 2021-03-31 | Univ California | Virus adéno-associés variants et procédés d'utilisation |
KR102508820B1 (ko) * | 2016-07-29 | 2023-03-13 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 변이체 캡시드를 갖는 아데노-관련된 바이러스 비리온 및 이의 사용 방법 |
-
2017
- 2017-06-14 MA MA44546A patent/MA44546B1/fr unknown
- 2017-06-15 WO PCT/US2017/037781 patent/WO2017218842A1/en active Application Filing
- 2017-06-15 AU AU2017286652A patent/AU2017286652B2/en active Active
- 2017-06-15 CN CN202211294452.6A patent/CN116003532A/zh active Pending
- 2017-06-15 DK DK17734575.8T patent/DK3472183T5/da active
- 2017-06-15 BR BR112018076090-0A patent/BR112018076090A2/pt unknown
- 2017-06-15 ES ES17734575T patent/ES2962611T3/es active Active
- 2017-06-15 HU HUE17734575A patent/HUE063755T2/hu unknown
- 2017-06-15 IL IL263719A patent/IL263719B2/en unknown
- 2017-06-15 US US16/310,332 patent/US10961282B2/en active Active
- 2017-06-15 FI FIEP17734575.8T patent/FI3472183T3/fi active
- 2017-06-15 IL IL300981A patent/IL300981A/en unknown
- 2017-06-15 KR KR1020237012530A patent/KR20230054754A/ko active Pending
- 2017-06-15 CA CA3028113A patent/CA3028113A1/en active Pending
- 2017-06-15 HR HRP20231403TT patent/HRP20231403T1/hr unknown
- 2017-06-15 EP EP23190144.8A patent/EP4268852A3/en active Pending
- 2017-06-15 SM SM20230372T patent/SMT202300372T1/it unknown
- 2017-06-15 JP JP2019518172A patent/JP7094277B2/ja active Active
- 2017-06-15 LT LTEPPCT/US2017/037781T patent/LT3472183T/lt unknown
- 2017-06-15 KR KR1020197001327A patent/KR102522661B1/ko active Active
- 2017-06-15 RS RS20231029A patent/RS64769B1/sr unknown
- 2017-06-15 SG SG11201811189RA patent/SG11201811189RA/en unknown
- 2017-06-15 EA EA201990033A patent/EA201990033A1/ru unknown
- 2017-06-15 PT PT177345758T patent/PT3472183T/pt unknown
- 2017-06-15 CN CN201780044853.7A patent/CN109641939B/zh active Active
- 2017-06-15 EP EP17734575.8A patent/EP3472183B1/en active Active
- 2017-06-15 PL PL17734575.8T patent/PL3472183T3/pl unknown
- 2017-06-15 MX MX2018015770A patent/MX2018015770A/es unknown
- 2017-06-15 SI SI201731418T patent/SI3472183T1/sl unknown
- 2017-06-15 MY MYPI2018002591A patent/MY190221A/en unknown
-
2018
- 2018-12-14 MX MX2024000505A patent/MX2024000505A/es unknown
- 2018-12-17 PH PH12018502664A patent/PH12018502664A1/en unknown
-
2019
- 2019-01-15 ZA ZA2019/00278A patent/ZA201900278B/en unknown
-
2021
- 2021-03-23 US US17/209,336 patent/US11939355B2/en active Active
- 2021-09-03 AU AU2021225247A patent/AU2021225247B2/en active Active
-
2022
- 2022-06-21 JP JP2022099286A patent/JP7579301B2/ja active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA201900278B (en) | Variant adeno-associated viruses and methods of using | |
HK1246355A1 (zh) | 腺相關病毒變體及其使用方法 | |
ZA201905485B (en) | Adeno-associated virus variant capsids and methods of use thereof | |
IL286316A (en) | New micro-dystrophins and related method of use | |
HRP20210526T8 (hr) | Oksisteroli i postupci za njihovu uporabu | |
IL289976A (en) | Oxysterols and methods of using them | |
IL250415B (en) | Antibodies against pd-l and methods of using them | |
HK1253049A1 (zh) | 糖基相互作用化合物及其使用方法 | |
HK1255500A1 (zh) | 氧固醇及其使用方法 | |
GB2539350B (en) | Amyloid targeting agents and methods of using the same | |
IL282482A (en) | Variants of protoxin-II and methods of use | |
GB201519128D0 (en) | Solid forms and methods of preparing the same | |
IL282508A (en) | Variants of protoxin-II and methods of use | |
PT3397364T (pt) | Elementos estruturados e métodos de utilização |