[go: up one dir, main page]

SMT202200159T1 - Terapia in combinazione con un anticorpo anti-cd19 e una mostarda azotata - Google Patents

Terapia in combinazione con un anticorpo anti-cd19 e una mostarda azotata

Info

Publication number
SMT202200159T1
SMT202200159T1 SM20220159T SMT202200159T SMT202200159T1 SM T202200159 T1 SMT202200159 T1 SM T202200159T1 SM 20220159 T SM20220159 T SM 20220159T SM T202200159 T SMT202200159 T SM T202200159T SM T202200159 T1 SMT202200159 T1 SM T202200159T1
Authority
SM
San Marino
Prior art keywords
antibody
combination therapy
nitrogen mustard
mustard
nitrogen
Prior art date
Application number
SM20220159T
Other languages
English (en)
Inventor
Mark Winderlich
Stefan Steidl
Susanne Krohn
Lisa Rojkjaer
Jutta Amersdorfer
Original Assignee
Morphosys Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morphosys Ag filed Critical Morphosys Ag
Publication of SMT202200159T1 publication Critical patent/SMT202200159T1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
SM20220159T 2011-08-16 2012-08-14 Terapia in combinazione con un anticorpo anti-cd19 e una mostarda azotata SMT202200159T1 (it)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201161523861P 2011-08-16 2011-08-16
EP11177658 2011-08-16
US201261647539P 2012-05-16 2012-05-16
US201261654097P 2012-06-01 2012-06-01
PCT/EP2012/065906 WO2013024097A1 (en) 2011-08-16 2012-08-14 Combination therapy with an anti - cd19 antibody and a nitrogen mustard
EP12747923.6A EP2744515B1 (en) 2011-08-16 2012-08-14 Combination therapy with an anti-cd19 antibody and a nitrogen mustard

Publications (1)

Publication Number Publication Date
SMT202200159T1 true SMT202200159T1 (it) 2022-05-12

Family

ID=47714801

Family Applications (1)

Application Number Title Priority Date Filing Date
SM20220159T SMT202200159T1 (it) 2011-08-16 2012-08-14 Terapia in combinazione con un anticorpo anti-cd19 e una mostarda azotata

Country Status (24)

Country Link
US (3) US20140255427A1 (it)
EP (2) EP2744515B1 (it)
JP (1) JP6184952B2 (it)
KR (3) KR20200058583A (it)
CN (1) CN103732252B (it)
AU (1) AU2012296907B2 (it)
BR (1) BR112013033919B1 (it)
CA (2) CA2841875C (it)
CY (1) CY1125122T1 (it)
DK (1) DK2744515T3 (it)
ES (1) ES2909722T3 (it)
HR (1) HRP20220228T1 (it)
HU (1) HUE058350T2 (it)
IL (1) IL230293B (it)
LT (1) LT2744515T (it)
MX (1) MX354479B (it)
PL (1) PL2744515T3 (it)
PT (1) PT2744515T (it)
RS (1) RS63238B1 (it)
RU (1) RU2625222C2 (it)
SG (1) SG10201606785UA (it)
SI (1) SI2744515T1 (it)
SM (1) SMT202200159T1 (it)
WO (1) WO2013024097A1 (it)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017519757A (ja) * 2014-06-16 2017-07-20 ゼンコー・インコーポレイテッドＸｅｎｃｏｒ、 Ｉｎｃ． 慢性リンパ球性白血病（ｃｌｌ）の処置
PL3302550T3 (pl) 2015-05-26 2020-02-28 Morphosys Ag Kombinacja przeciwciała anty-cd19 i inhibitora kinazy tyrozynowej brutona i jej zastosowania
EP3337506B1 (en) 2015-08-21 2021-07-21 MorphoSys AG Combinations and uses thereof
CN109715207B (zh) 2016-03-29 2023-03-31 南加利福尼亚大学 靶向癌症的嵌合抗原受体
LT3916392T (lt) * 2016-05-30 2024-08-26 Incyte Corporation Pacientų gydymo anti-cd19 terapinės naudos prognozavimo būdai
RS62036B1 (sr) * 2016-10-28 2021-07-30 Morphosys Ag Kombinacija anti cd19 antitela sa bcl-2 inhibitorom i njihova upotreba
CN110352068A (zh) 2016-12-02 2019-10-18 南加利福尼亚大学 合成的免疫受体及其使用方法
CA3062400A1 (en) 2017-05-31 2018-12-06 Morphosys Ag Treatment paradigm for an anti-cd19 antibody and venetoclax combination treatment
KR20200030337A (ko) 2018-09-12 2020-03-20 주식회사 녹십자랩셀 종양 치료를 위한 항-cd 19 항체 및 자연살해세포를 포함하는 약학적 조합물
IL313736A (en) * 2021-12-22 2024-08-01 Incyte Corp Treatment paradigm for CD19 antibody therapy

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1247080A (en) 1983-03-08 1988-12-20 Commonwealth Serum Laboratories Commission Antigenically active amino acid sequences
US5686072A (en) 1992-06-17 1997-11-11 Board Of Regents, The University Of Texas Epitope-specific monoclonal antibodies and immunotoxins and uses thereof
TR200003087T2 (tr) * 1998-04-21 2001-02-21 Micromet Ag Yeni CD19 X CD3 Spesifik polipeptidler ve kullanımları
EP1176981B1 (en) * 1999-05-07 2005-11-30 Genentech, Inc. Treatment of autoimmune diseases with antagonists which bind to b cell surface markers
US20020058029A1 (en) 2000-09-18 2002-05-16 Nabil Hanna Combination therapy for treatment of autoimmune diseases using B cell depleting/immunoregulatory antibody combination
ES2307832T3 (es) 2001-12-03 2008-12-01 Amgen Fremont Inc. Clasificacion de anticuerpos basada en las caracteristicas de union.
US20080260731A1 (en) * 2002-03-01 2008-10-23 Bernett Matthew J Optimized antibodies that target cd19
US7902338B2 (en) 2003-07-31 2011-03-08 Immunomedics, Inc. Anti-CD19 antibodies
EP2216342B1 (en) 2003-07-31 2015-04-22 Immunomedics, Inc. Anti-CD19 antibodies
CA2585659A1 (en) 2004-11-05 2006-06-22 Cephalon, Inc. Cancer treatments
CA2611814A1 (en) 2005-06-20 2007-01-04 Medarex, Inc. Cd19 antibodies and their uses
DK2270050T3 (da) 2005-12-30 2013-08-12 Merck Patent Gmbh Anti-CD19-antistoffer med nedsat immunogenicitet
ME01786B (me) * 2006-08-14 2014-09-20 Xencor Inc Optimizovana antitela usmerena na cd19
WO2008031056A2 (en) 2006-09-08 2008-03-13 Medimmune, Llc Humanized anti-cd19 antibodies and their use in treatment of oncology, transplantation and autoimmune disease
EP3392273A1 (en) 2007-05-30 2018-10-24 Xencor, Inc. Methods and compositions for inhibiting cd32b expressing cells
CN101903403B (zh) 2007-10-19 2016-03-16 西雅图基因公司 Cd19结合剂及其应用
SG172792A1 (en) * 2009-01-16 2011-08-29 Glaxosmithkline Llc Treatment of a cancer using a combination of bendamustine and an anti-cd20 antibody
EA201190132A1 (ru) 2009-02-23 2013-01-30 Гленмарк Фармасьютикалс С.А. Гуманизированные антитела, связывающиеся с cd19, и их применение
AU2010263272C1 (en) 2009-06-24 2016-02-11 The Feinstein Institute For Medical Research Method for treating chronic lymphocytic leukemia
TWI409079B (zh) * 2009-08-14 2013-09-21 Roche Glycart Ag 非典型岩藻醣化ｃｄ２０抗體與苯達莫斯汀（ｂｅｎｄａｍｕｓｔｉｎｅ）之組合療法
KR20120054069A (ko) * 2009-08-14 2012-05-29 로슈 글리카트 아게 플루다라빈 및/또는 미토잔트론과 어푸코실화된 ｃｄ20 항체의 복합 요법
CA2779424A1 (en) * 2009-11-06 2011-05-12 Infinity Pharmaceuticals, Inc. Oral formulations of a hedgehog pathway inhibitor

Also Published As

Publication number Publication date
MX354479B (es) 2018-03-07
US20140255427A1 (en) 2014-09-11
PL2744515T3 (pl) 2022-05-30
US20240366756A1 (en) 2024-11-07
BR112013033919A2 (pt) 2017-12-19
SG10201606785UA (en) 2016-10-28
JP6184952B2 (ja) 2017-08-23
KR20190107749A (ko) 2019-09-20
CA2841875A1 (en) 2013-02-21
CN103732252A (zh) 2014-04-16
AU2012296907B2 (en) 2017-01-05
PT2744515T (pt) 2022-05-19
IL230293B (en) 2019-01-31
CN103732252B (zh) 2017-11-10
JP2014525926A (ja) 2014-10-02
RU2014103492A (ru) 2015-09-27
KR20200058583A (ko) 2020-05-27
BR112013033919B1 (pt) 2022-11-16
SI2744515T1 (sl) 2022-05-31
US20200353077A1 (en) 2020-11-12
CY1125122T1 (el) 2024-12-13
RS63238B1 (sr) 2022-06-30
EP2744515B1 (en) 2022-02-09
MX2013014933A (es) 2014-04-16
HRP20220228T1 (hr) 2022-05-13
EP4062936A1 (en) 2022-09-28
EP2744515A1 (en) 2014-06-25
RU2625222C2 (ru) 2017-07-12
CA3137321A1 (en) 2013-02-21
WO2013024097A1 (en) 2013-02-21
ES2909722T3 (es) 2022-05-10
CA2841875C (en) 2021-11-02
HUE058350T2 (hu) 2022-07-28
LT2744515T (lt) 2022-04-25
DK2744515T3 (da) 2022-03-28
KR20140064873A (ko) 2014-05-28
NZ617770A (en) 2016-01-29
KR102115203B1 (ko) 2020-05-28

Similar Documents

Publication Publication Date Title
IL281250A (en) Anti-PHF-tau antibodies and uses thereof
IL272831B (en) Meditops and Meditop binding antibodies and their use
IL230293B (en) Combined treatment with anti-19cd antibody and nitrogen mustard
IL259436A (en) Antibodies against 3angptl and their uses
DK2729170T3 (en) Antibody variants and uses thereof
ZA201401843B (en) Antibodies against tl1a and uses thereof
IL232399A0 (en) Anti-2fgfr antibodies and their use
EP2756094A4 (en) ANTI-B7-H4 ANTIBODIES AND USES THEREOF
ZA201401835B (en) Combination therapy with an anti-cd19 antibody and a purine analog
EP2690427A4 (en) DEVICE FOR REINFORCING OPTICAL ELECTRICAL FIELDS AND MEASURING DEVICE THEREWITH
ZA201306848B (en) Transverse driven-roller belt and convetor
GB201102708D0 (en) Improved containers and assembly thereof