SMT201700110B - Composizione immunogena - Google Patents

Composizione immunogena

Info

Publication number: SMT201700110B
Authority: SM; San Marino
Prior art keywords: immunogenic composition; immunogenic; composition
Prior art date: 2011-05-27

Application number

SM201700110T

Other languages

English (en)

Inventor

Cindy Castado

Original Assignee

Glaxosmithkline Biolog Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-05-27

Filing date

2017-02-16

Publication date

2017-03-08

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46168484&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SMT201700110(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2017-02-16 Application filed by Glaxosmithkline Biolog Sa filed Critical Glaxosmithkline Biolog Sa

2017-03-08 Publication of SMT201700110B publication Critical patent/SMT201700110B/it

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1282—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Microbiology (AREA)
Biomedical Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Mycology (AREA)
Zoology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Gastroenterology & Hepatology (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

SM201700110T 2011-05-27 2017-02-16 Composizione immunogena SMT201700110B (it)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US201161490716P	2011-05-27	2011-05-27
US201161490707P	2011-05-27	2011-05-27
US201161490734P	2011-05-27	2011-05-27
PCT/EP2012/059793 WO2012163811A1 (en)	2011-05-27	2012-05-25	Immunogenic composition
US201314122690A	2013-11-27	2013-11-27
US15/041,924 US9644024B2 (en)	2011-05-27	2016-02-11	Nucleotide sequences, vectors and host cells

Publications (1)

Publication Number	Publication Date
SMT201700110B true SMT201700110B (it)	2017-03-08

Family

ID=46168484

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SM20170110T SMT201700110T1 (it)	2011-05-27	2012-05-25	Composizione immunogena
SM201700110T SMT201700110B (it)	2011-05-27	2017-02-16	Composizione immunogena

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
SM20170110T SMT201700110T1 (it)	2011-05-27	2012-05-25	Composizione immunogena

Country Status (25)

Country	Link
US (5)	US9409974B2 (it)
EP (6)	EP3138916B1 (it)
JP (3)	JP5952390B2 (it)
KR (1)	KR102014502B1 (it)
CN (3)	CN107098977A (it)
BR (2)	BR112013030396A2 (it)
CA (2)	CA2837395C (it)
CY (3)	CY1118599T1 (it)
DK (4)	DK3138916T3 (it)
EA (1)	EA030898B1 (it)
ES (4)	ES2660468T3 (it)
FI (1)	FI3564378T3 (it)
HR (4)	HRP20170094T1 (it)
HU (4)	HUE044772T2 (it)
IL (1)	IL229529B2 (it)
LT (4)	LT2714910T (it)
ME (1)	ME02600B (it)
MX (1)	MX346200B (it)
PL (4)	PL2714911T3 (it)
PT (4)	PT3564378T (it)
RS (1)	RS55605B1 (it)
SG (1)	SG195037A1 (it)
SI (4)	SI3564378T1 (it)
SM (2)	SMT201700110T1 (it)
WO (3)	WO2012163811A1 (it)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2867375T3 (es)	2010-09-03	2021-10-20	Valneva Austria Gmbh	Polipéptido aislado de las proteínas de la toxina A y la toxina B de C. difficile y sus usos
BR112013027229B1 (pt)	2011-04-22	2020-10-27	Wyeth Llc	polipeptídeo imunogênico isolado e seu uso, composição imunogênica e seu uso, célula recombinante ou progênie da mesma, e método de produção de uma toxina de clostridium difficile mutante
JP6084631B2 (ja)	2011-12-08	2017-02-22	ノバルティスアーゲー	Ｃｌｏｓｔｒｉｄｉｕｍｄｉｆｆｉｃｉｌｅ毒素ベースのワクチン
BR122016023101B1 (pt) *	2012-10-21	2022-03-22	Pfizer Inc	Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile
PL3513806T3 (pl) *	2012-12-05	2023-05-15	Glaxosmithkline Biologicals Sa	Imunogenna kompozycja
EP2988778A4 (en) *	2013-04-22	2016-12-14	Board Of Regents Of The Univ Of Oklahoma	CLOSTRIDIUM DIFFICILE IMPREGENT AND METHOD OF USE
ES2870506T3 (es)	2015-02-19	2021-10-27	Immune Biosolutions Inc	Antígeno y anticuerpo del epítopo de las toxinas a y/o b de clostridium difficile, y sus usos farmacéuticos
EP3810163A1 (en)	2018-06-19	2021-04-28	GlaxoSmithKline Biologicals SA	Immunogenic composition
WO2023020994A1 (en)	2021-08-16	2023-02-23	Glaxosmithkline Biologicals Sa	Novel methods
WO2023020992A1 (en)	2021-08-16	2023-02-23	Glaxosmithkline Biologicals Sa	Novel methods
WO2023020993A1 (en)	2021-08-16	2023-02-23	Glaxosmithkline Biologicals Sa	Novel methods
GB202205833D0 (en)	2022-04-21	2022-06-08	Glaxosmithkline Biologicals Sa	Bacteriophage
EP4531899A1 (en)	2022-06-01	2025-04-09	Valneva Austria GmbH	Clostridium difficile vaccine
CN120615016A (zh)	2023-02-02	2025-09-09	葛兰素史克生物有限公司	免疫原性组合物

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4235877A (en)	1979-06-27	1980-11-25	Merck & Co., Inc.	Liposome particle containing viral or bacterial antigenic subunit
US4751180A (en)	1985-03-28	1988-06-14	Chiron Corporation	Expression using fused genes providing for protein product
US4935233A (en)	1985-12-02	1990-06-19	G. D. Searle And Company	Covalently linked polypeptide cell modulators
PL320214A1 (en) *	1994-10-24	1997-09-15	Ophidian Pharmaceuticals	Vaccine and antitoxin for treating and preventing a disease caused by c.difficile
EP0837692B1 (en) *	1995-07-07	2000-08-30	Oravax, Inc.	Clostridium difficile toxins and toxoids as mucosal adjuvants
WO2000061761A2 (en) *	1999-04-09	2000-10-19	Techlab, Inc.	Recombinant clostridium toxin a protein carrier for polysaccharide conjugate vaccines
AU781175B2 (en) *	1999-04-09	2005-05-12	Intercell Usa, Inc.	Recombinant toxin A/toxin B vaccine against Clostridium Difficile
WO2001073030A2 (en)	2000-03-28	2001-10-04	Diadexus, Inc.	Compositions and methods of diagnosing, monitoring, staging, imaging and treating colon cancer
US20120020996A1 (en) *	2008-08-06	2012-01-26	Jonathan Lewis Telfer	Vaccines against clostridium difficile and methods of use
WO2011060431A2 (en) *	2009-11-16	2011-05-19	University Of Maryland Baltimore	Multivalent live vector vaccine against clostridium difficile-associated disease
ES2867375T3 (es) *	2010-09-03	2021-10-20	Valneva Austria Gmbh	Polipéptido aislado de las proteínas de la toxina A y la toxina B de C. difficile y sus usos
GB201016742D0 (en) *	2010-10-05	2010-11-17	Health Prot Agency	Clostridium difficile antigens

2012
- 2012-05-25 LT LTEP12724950.6T patent/LT2714910T/lt unknown
- 2012-05-25 EA EA201391548A patent/EA030898B1/ru not_active IP Right Cessation
- 2012-05-25 LT LTEP16193340.3T patent/LT3138916T/lt unknown
- 2012-05-25 CN CN201710239709.0A patent/CN107098977A/zh active Pending
- 2012-05-25 SI SI201232050T patent/SI3564378T1/sl unknown
- 2012-05-25 LT LTEP12726374.7T patent/LT2714911T/lt unknown
- 2012-05-25 HR HRP20170094TT patent/HRP20170094T1/hr unknown
- 2012-05-25 CN CN201280037466.8A patent/CN103732750A/zh active Pending
- 2012-05-25 CA CA2837395A patent/CA2837395C/en active Active
- 2012-05-25 DK DK16193340.3T patent/DK3138916T3/da active
- 2012-05-25 HU HUE16193340 patent/HUE044772T2/hu unknown
- 2012-05-25 FI FIEP19179871.9T patent/FI3564378T3/fi active
- 2012-05-25 HU HUE12724950A patent/HUE037126T2/hu unknown
- 2012-05-25 HU HUE19179871A patent/HUE064492T2/hu unknown
- 2012-05-25 ES ES12724950.6T patent/ES2660468T3/es active Active
- 2012-05-25 SI SI201231247T patent/SI2714910T1/en unknown
- 2012-05-25 JP JP2014511899A patent/JP5952390B2/ja active Active
- 2012-05-25 SM SM20170110T patent/SMT201700110T1/it unknown
- 2012-05-25 RS RS20170051A patent/RS55605B1/sr unknown
- 2012-05-25 DK DK12726374.7T patent/DK2714911T3/en active
- 2012-05-25 PT PT191798719T patent/PT3564378T/pt unknown
- 2012-05-25 WO PCT/EP2012/059793 patent/WO2012163811A1/en not_active Ceased
- 2012-05-25 BR BR112013030396A patent/BR112013030396A2/pt not_active IP Right Cessation
- 2012-05-25 WO PCT/EP2012/059792 patent/WO2012163810A1/en not_active Ceased
- 2012-05-25 EP EP16193340.3A patent/EP3138916B1/en not_active Revoked
- 2012-05-25 ES ES16193340T patent/ES2743442T3/es active Active
- 2012-05-25 MX MX2013013924A patent/MX346200B/es active IP Right Grant
- 2012-05-25 SI SI201230868A patent/SI2714911T1/sl unknown
- 2012-05-25 DK DK12724950.6T patent/DK2714910T3/en active
- 2012-05-25 ME MEP-2017-26A patent/ME02600B/me unknown
- 2012-05-25 KR KR1020137034795A patent/KR102014502B1/ko active Active
- 2012-05-25 HU HUE12726374A patent/HUE030823T2/en unknown
- 2012-05-25 SG SG2013085386A patent/SG195037A1/en unknown
- 2012-05-25 ES ES12726374.7T patent/ES2615737T3/es active Active
- 2012-05-25 ES ES19179871T patent/ES2968455T3/es active Active
- 2012-05-25 PL PL12726374T patent/PL2714911T3/pl unknown
- 2012-05-25 US US14/122,345 patent/US9409974B2/en active Active
- 2012-05-25 LT LTEP19179871.9T patent/LT3564378T/lt unknown
- 2012-05-25 HR HRP20231749TT patent/HRP20231749T1/hr unknown
- 2012-05-25 SI SI201231642T patent/SI3138916T1/sl unknown
- 2012-05-25 EP EP18150735.1A patent/EP3327126A1/en not_active Withdrawn
- 2012-05-25 PT PT16193340T patent/PT3138916T/pt unknown
- 2012-05-25 JP JP2014511895A patent/JP2014516532A/ja active Pending
- 2012-05-25 US US14/122,690 patent/US9290565B2/en not_active Expired - Fee Related
- 2012-05-25 EP EP12724950.6A patent/EP2714910B1/en active Active
- 2012-05-25 CN CN201280037472.3A patent/CN103717742B/zh active Active
- 2012-05-25 BR BR112013030395-6A patent/BR112013030395B1/pt active IP Right Grant
- 2012-05-25 EP EP12726374.7A patent/EP2714911B1/en not_active Revoked
- 2012-05-25 PL PL16193340T patent/PL3138916T3/pl unknown
- 2012-05-25 PL PL12724950T patent/PL2714910T3/pl unknown
- 2012-05-25 HR HRP20180339TT patent/HRP20180339T1/hr unknown
- 2012-05-25 PL PL19179871.9T patent/PL3564378T3/pl unknown
- 2012-05-25 EP EP19179871.9A patent/EP3564378B1/en not_active Revoked
- 2012-05-25 PT PT127249506T patent/PT2714910T/pt unknown
- 2012-05-25 DK DK19179871.9T patent/DK3564378T5/da active
- 2012-05-25 WO PCT/EP2012/059805 patent/WO2012163817A2/en not_active Ceased
- 2012-05-25 PT PT127263747T patent/PT2714911T/pt unknown
- 2012-05-25 CA CA2837393A patent/CA2837393A1/en not_active Abandoned
- 2012-05-25 EP EP23205566.5A patent/EP4296361A3/en active Pending
2013
- 2013-11-21 IL IL229529A patent/IL229529B2/en unknown
2016
- 2016-02-11 US US15/041,924 patent/US9644024B2/en not_active Expired - Fee Related
- 2016-06-09 JP JP2016114910A patent/JP2017012160A/ja active Pending
- 2016-06-28 US US15/194,937 patent/US10093722B2/en active Active
2017
- 2017-02-03 CY CY20171100158T patent/CY1118599T1/el unknown
- 2017-02-16 SM SM201700110T patent/SMT201700110B/it unknown
- 2017-03-21 US US15/464,454 patent/US10377816B2/en active Active
2018
- 2018-02-15 CY CY20181100188T patent/CY1119916T1/el unknown
2019
- 2019-07-17 HR HRP20191291TT patent/HRP20191291T1/hr unknown
- 2019-08-27 CY CY20191100909T patent/CY1121936T1/el unknown

Also Published As

Publication number	Publication date
PL3138916T3 (pl)	2019-11-29
SG195037A1 (en)	2013-12-30
US9644024B2 (en)	2017-05-09
ES2660468T3 (es)	2018-03-22
ES2615737T3 (es)	2017-06-08
IL229529B2 (en)	2023-05-01
KR102014502B1 (ko)	2019-08-26
ES2743442T3 (es)	2020-02-19
MX2013013924A (es)	2013-12-16
DK3564378T5 (da)	2024-09-02
MX346200B (es)	2017-03-10
EA030898B1 (ru)	2018-10-31
US20140093529A1 (en)	2014-04-03
PT3564378T (pt)	2024-01-26
ME02600B (me)	2017-06-20
BR112013030395A2 (pt)	2016-12-13
CN103732750A (zh)	2014-04-16
US10093722B2 (en)	2018-10-09
US10377816B2 (en)	2019-08-13
IL229529B1 (en)	2023-01-01
US20140178424A1 (en)	2014-06-26
PL3564378T3 (pl)	2024-03-11
EP2714910A1 (en)	2014-04-09
SI2714910T1 (en)	2018-04-30
CA2837395A1 (en)	2012-12-06
HRP20180339T1 (hr)	2018-03-23
EP4296361A2 (en)	2023-12-27
LT3138916T (lt)	2019-08-26
JP2014522238A (ja)	2014-09-04
HUE030823T2 (en)	2017-06-28
WO2012163811A1 (en)	2012-12-06
US9409974B2 (en)	2016-08-09
KR20140019848A (ko)	2014-02-17
EP3327126A1 (en)	2018-05-30
PL2714910T3 (pl)	2018-06-29
IL229529A0 (en)	2014-01-30
BR112013030396A2 (pt)	2016-12-13
WO2012163817A2 (en)	2012-12-06
RS55605B1 (sr)	2017-06-30
PL2714911T3 (pl)	2017-05-31
HRP20231749T1 (hr)	2024-03-15
HUE064492T2 (hu)	2024-03-28
BR112013030395B1 (pt)	2022-11-01
DK2714911T3 (en)	2017-02-27
CA2837393A1 (en)	2012-12-06
CN107098977A (zh)	2017-08-29
EP3564378B1 (en)	2023-11-01
LT2714911T (lt)	2017-02-10
US20170362309A1 (en)	2017-12-21
PT2714910T (pt)	2018-03-09
LT2714910T (lt)	2018-03-12
PT3138916T (pt)	2019-09-17
CA2837395C (en)	2021-05-18
EP2714911B1 (en)	2016-11-30
EP4296361A3 (en)	2024-02-28
DK2714910T3 (en)	2018-02-05
PT2714911T (pt)	2017-02-06
HUE037126T2 (hu)	2018-08-28
EP2714910B1 (en)	2018-01-10
EP3138916A1 (en)	2017-03-08
HRP20191291T1 (hr)	2019-10-18
US20170247421A1 (en)	2017-08-31
SI3138916T1 (sl)	2019-08-30
JP2017012160A (ja)	2017-01-19
DK3564378T3 (da)	2024-01-08
EA201391548A1 (ru)	2014-06-30
LT3564378T (lt)	2024-01-25
HRP20170094T1 (hr)	2017-03-24
FI3564378T3 (fi)	2024-01-18
HUE044772T2 (hu)	2019-11-28
JP2014516532A (ja)	2014-07-17
SI3564378T1 (sl)	2024-02-29
ES2968455T3 (es)	2024-05-09
SMT201700110T1 (it)	2017-03-08
CY1119916T1 (el)	2018-06-27
WO2012163810A1 (en)	2012-12-06
US9290565B2 (en)	2016-03-22
EP3138916B1 (en)	2019-06-19
DK3138916T3 (da)	2019-08-26
JP5952390B2 (ja)	2016-07-13
CY1121936T1 (el)	2020-10-14
CN103717742A (zh)	2014-04-09
EP2714911A2 (en)	2014-04-09
SI2714911T1 (sl)	2017-03-31
US20160159867A1 (en)	2016-06-09
CN103717742B (zh)	2018-05-22
CY1118599T1 (el)	2017-07-12
EP3564378A1 (en)	2019-11-06
WO2012163817A3 (en)	2013-03-21

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