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SMT201700106B - Produzione di n-acetilgalattosammin-6-solfatasi di essere umano altamente fosforilata attiva e suoi usi - Google Patents

Produzione di n-acetilgalattosammin-6-solfatasi di essere umano altamente fosforilata attiva e suoi usi

Info

Publication number
SMT201700106B
SMT201700106B SM201700106T SM201700106T SMT201700106B SM T201700106 B SMT201700106 B SM T201700106B SM 201700106 T SM201700106 T SM 201700106T SM 201700106 T SM201700106 T SM 201700106T SM T201700106 B SMT201700106 B SM T201700106B
Authority
SM
San Marino
Prior art keywords
sulphatasis
acetylgalactosammin
phosphorilated
activity
production
Prior art date
Application number
SM201700106T
Other languages
English (en)
Inventor
Vish Koppaka
Michel Claude Vellard
Kidisti Araya
Augustus O Okhamafe
Original Assignee
Biomarin Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomarin Pharm Inc filed Critical Biomarin Pharm Inc
Publication of SMT201700106B publication Critical patent/SMT201700106B/it

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/465Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y301/00Hydrolases acting on ester bonds (3.1)
    • C12Y301/06Sulfuric ester hydrolases (3.1.6)
    • C12Y301/06004N-Acetylgalactosamine-6-sulfatase (3.1.6.4)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SM201700106T 2010-07-22 2017-02-16 Produzione di n-acetilgalattosammin-6-solfatasi di essere umano altamente fosforilata attiva e suoi usi SMT201700106B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36671410P 2010-07-22 2010-07-22

Publications (1)

Publication Number Publication Date
SMT201700106B true SMT201700106B (it) 2017-03-08

Family

ID=44543776

Family Applications (2)

Application Number Title Priority Date Filing Date
SM20170106T SMT201700106T1 (it) 2010-07-22 2011-07-22 Produzione di n-acetilgalattosammin-6-solfatasi di essere umano altamente fosforilata attiva e suoi usi
SM201700106T SMT201700106B (it) 2010-07-22 2017-02-16 Produzione di n-acetilgalattosammin-6-solfatasi di essere umano altamente fosforilata attiva e suoi usi

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SM20170106T SMT201700106T1 (it) 2010-07-22 2011-07-22 Produzione di n-acetilgalattosammin-6-solfatasi di essere umano altamente fosforilata attiva e suoi usi

Country Status (28)

Country Link
US (3) US8765437B2 (it)
EP (1) EP2595650B1 (it)
JP (2) JP6030553B2 (it)
KR (2) KR101598897B1 (it)
CN (1) CN103037895B (it)
AR (2) AR082319A1 (it)
AU (1) AU2011280937B2 (it)
BR (1) BR112013001558B1 (it)
CA (2) CA3146151A1 (it)
CL (2) CL2013000219A1 (it)
CY (1) CY1118934T1 (it)
DK (1) DK2595650T3 (it)
ES (1) ES2616263T3 (it)
HR (1) HRP20170245T1 (it)
HU (1) HUE033163T2 (it)
IL (2) IL224125B (it)
LT (1) LT2595650T (it)
MX (1) MX341838B (it)
PE (3) PE20171799A1 (it)
PL (1) PL2595650T3 (it)
PT (1) PT2595650T (it)
RS (1) RS55669B1 (it)
RU (1) RU2607376C2 (it)
SG (1) SG187580A1 (it)
SI (1) SI2595650T1 (it)
SM (2) SMT201700106T1 (it)
WO (1) WO2012012718A2 (it)
ZA (1) ZA201300286B (it)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3219795T3 (pl) * 2008-01-18 2024-09-16 Biomarin Pharmaceutical Inc. Wytwarzanie aktywnych wysoce fosforylowanych ludzkich enzymów sulfatazy lizosomalnej i ich zastosowania
US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
WO2013119715A1 (en) * 2012-02-07 2013-08-15 Saint Louis University Determination of immunogenic peptides in lysosomal enzymes and induction of oral tolerance
KR101380740B1 (ko) 2012-06-29 2014-04-11 쉐어 휴먼 제네텍 세러피스, 인코포레이티드 이듀로네이트-2-설파타제의 정제
US11529397B2 (en) 2018-01-22 2022-12-20 Saint Louis University Method of treating mucopolysaccharidosis type IVA
EP3441072B1 (en) 2013-03-13 2020-12-30 Seagen Inc. Activated carbon filtration for purification of benzodiazepine adcs
JP2016518113A (ja) * 2013-03-13 2016-06-23 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド リソソーム系酵素の特性評価の方法
BR112015028605A8 (pt) * 2013-05-15 2019-12-24 Univ Minnesota uso de uma composição e uso de um imunossupressor e uma composição
WO2014201220A1 (en) * 2013-06-12 2014-12-18 The Board Of Trustees Of The University Of Illinois Methods for detecting prostate cancer
WO2015005961A1 (en) 2013-07-12 2015-01-15 Emd Millipore Corporation A method of determining virus removal from a sample containing a target protein using activated carbon
WO2016007909A2 (en) * 2014-07-11 2016-01-14 Biostrategies LC Materials and methods for treating disorders associated with sulfatase enzymes
US10472615B2 (en) 2016-01-21 2019-11-12 Saint Louis University Reduced immunogenic proteins for lysosomal storage disorders
EP3448885A4 (en) 2016-04-26 2020-01-08 R.P. Scherer Technologies, LLC ANTIBODY CONJUGATES AND METHOD FOR THE PRODUCTION AND USE THEREOF
KR102286260B1 (ko) * 2017-08-31 2021-08-05 주식회사 녹십자 설파타아제 단백질을 정제하는 방법
SG11202011777PA (en) * 2018-05-30 2020-12-30 Esteve Pharmaceuticals Sa Adenoassociated virus vectors for the treatment of mucopolysaccharidoses type iv a
RU2763990C2 (ru) * 2020-02-19 2022-01-12 Акционерное общество "ГЕНЕРИУМ" Клетка, продуцирующая с высокой эффективностью активный белок арилсульфатазу в, и способ получения этой клетки
US20230193205A1 (en) * 2020-04-19 2023-06-22 Figene, Llc Gene modified fibroblasts for therapeutic applications
US20250134967A1 (en) * 2022-02-07 2025-05-01 M6P Therapeutics, Inc. Compositions comprising acid alpha glucosidase and methods of use thereof
TW202403043A (zh) * 2022-03-18 2024-01-16 美商健臻公司 重組人類酸性鞘磷脂酶醫藥組合物及方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4394448A (en) 1978-02-24 1983-07-19 Szoka Jr Francis C Method of inserting DNA into living cells
US4391904A (en) 1979-12-26 1983-07-05 Syva Company Test strip kits in immunoassays and compositions therein
US4554101A (en) 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US5186941A (en) 1983-05-06 1993-02-16 Vestar, Inc. Vesicle formulation for the controlled release of therapeutic agents
JPS62122588A (ja) 1985-11-22 1987-06-03 Taiyo Fishery Co Ltd 純コンドロイチナ−ゼの製造法
US6048729A (en) 1987-05-01 2000-04-11 Transkaryotic Therapies, Inc. In vivo protein production and delivery system for gene therapy
PT101031B (pt) 1991-11-05 2002-07-31 Transkaryotic Therapies Inc Processo para o fornecimento de proteinas por terapia genetica
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
TW492882B (en) 1997-11-28 2002-07-01 Caleb Pharmaceuticals Inc Cholinergic antagonist plaster composition
US6689600B1 (en) * 1998-11-16 2004-02-10 Introgen Therapeutics, Inc. Formulation of adenovirus for gene therapy
US7083793B2 (en) 1999-02-26 2006-08-01 Millennium Pharmaceuticals, Inc. Tango 243 polypeptides and uses thereof
US6534300B1 (en) 1999-09-14 2003-03-18 Genzyme Glycobiology Research Institute, Inc. Methods for producing highly phosphorylated lysosomal hydrolases
US6261595B1 (en) 2000-02-29 2001-07-17 Zars, Inc. Transdermal drug patch with attached pocket for controlled heating device
RU2195492C2 (ru) * 2000-09-04 2002-12-27 Институт физиологии Коми научного центра Уральского отделения РАН Способ получения пектолитического ферментного препарата
CA2435972C (en) 2001-01-26 2011-09-13 University Of Lausanne Matrix attachment regions and methods for use thereof
JP2006508643A (ja) * 2002-07-01 2006-03-16 アーキオン ライフ サイエンシーズ エルエルシー ディー/ビー/エー バイオ−テクニカル リソーセズ ディビジョン グルコサミンおよびn−アセチルグルコサミン製造のためのプロセスおよび材料
EP2325302B1 (en) 2003-02-11 2016-01-06 Shire Human Genetic Therapies, Inc. Cells that coexpress a sulfatase and a C-formylglycine generating enzyme and methods and uses thereof
JP2007277094A (ja) * 2004-06-29 2007-10-25 Chemo Sero Therapeut Res Inst 改変ダニ主要アレルゲン含有医薬組成物
WO2006073846A2 (en) * 2004-12-22 2006-07-13 Ambrx, Inc. Methods for expression and purification of recombinant human growth hormone
JP2009534390A (ja) * 2006-04-21 2009-09-24 アムジェン インコーポレイテッド 生物医薬品製剤のための緩衝剤
US20080231439A1 (en) 2007-03-22 2008-09-25 Inventec Corporation Activity Detection Circuit for a Storage Device
KR20210049186A (ko) * 2007-11-30 2021-05-04 애브비 바이오테크놀로지 리미티드 단백질 제형 및 이의 제조방법
PL3219795T3 (pl) * 2008-01-18 2024-09-16 Biomarin Pharmaceutical Inc. Wytwarzanie aktywnych wysoce fosforylowanych ludzkich enzymów sulfatazy lizosomalnej i ich zastosowania
US7722865B2 (en) * 2008-01-18 2010-05-25 Biomarin Pharmaceutical Inc. Manufacture of active highly phosphorylated human lysosomal sulfatase enzymes and uses thereof
EP2196476A1 (en) * 2008-12-10 2010-06-16 Novartis Ag Antibody formulation

Also Published As

Publication number Publication date
US8940513B2 (en) 2015-01-27
RU2013107765A (ru) 2014-08-27
JP6030553B2 (ja) 2016-11-24
BR112013001558B1 (pt) 2022-08-16
HRP20170245T1 (hr) 2017-04-21
CN103037895A (zh) 2013-04-10
MX2013000908A (es) 2013-07-05
EP2595650B1 (en) 2016-11-16
PE20131140A1 (es) 2013-10-17
ZA201300286B (en) 2014-03-26
US20160186149A1 (en) 2016-06-30
KR20150038715A (ko) 2015-04-08
AU2011280937A1 (en) 2013-01-31
US20140341878A1 (en) 2014-11-20
US9567572B2 (en) 2017-02-14
BR112013001558A2 (pt) 2020-08-04
ES2616263T3 (es) 2017-06-12
RU2607376C2 (ru) 2017-01-10
AR119552A2 (es) 2021-12-29
PE20171798A1 (es) 2017-12-28
LT2595650T (lt) 2017-03-10
CY1118934T1 (el) 2018-01-10
RS55669B1 (sr) 2017-06-30
SMT201700106T1 (it) 2017-03-08
SG187580A1 (en) 2013-03-28
CA2805673C (en) 2022-04-05
KR20130105605A (ko) 2013-09-25
SI2595650T1 (sl) 2017-04-26
IL260282B (en) 2020-05-31
JP2013532986A (ja) 2013-08-22
AR082319A1 (es) 2012-11-28
WO2012012718A2 (en) 2012-01-26
PE20171799A1 (es) 2017-12-28
CL2013000219A1 (es) 2014-07-11
US20120189605A1 (en) 2012-07-26
DK2595650T3 (en) 2017-02-27
PL2595650T3 (pl) 2017-06-30
CL2017000498A1 (es) 2017-11-24
CA3146151A1 (en) 2012-01-26
US8765437B2 (en) 2014-07-01
KR101949906B1 (ko) 2019-04-22
CN103037895B (zh) 2016-11-09
EP2595650A2 (en) 2013-05-29
HUE033163T2 (en) 2017-11-28
KR101598897B1 (ko) 2016-03-03
PT2595650T (pt) 2017-02-22
MX341838B (es) 2016-09-05
AU2011280937B2 (en) 2016-06-09
IL260282A (en) 2018-07-31
WO2012012718A3 (en) 2012-04-05
CA2805673A1 (en) 2012-01-26
IL224125B (en) 2019-02-28
JP2016178950A (ja) 2016-10-13

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