SMT201600398B - Inibitori di proteina chinasi (varianti), uso di questi nel trattamento di malattie oncologiche e composizione farmaceutica basata su questi - Google Patents
Inibitori di proteina chinasi (varianti), uso di questi nel trattamento di malattie oncologiche e composizione farmaceutica basata su questiInfo
- Publication number
- SMT201600398B SMT201600398B SM201600398T SM201600398T SMT201600398B SM T201600398 B SMT201600398 B SM T201600398B SM 201600398 T SM201600398 T SM 201600398T SM 201600398 T SM201600398 T SM 201600398T SM T201600398 B SMT201600398 B SM T201600398B
- Authority
- SM
- San Marino
- Prior art keywords
- chinase
- inhibitors
- variant
- protein
- treatment
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000000771 oncological effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2011124304/04A RU2477723C2 (ru) | 2011-06-16 | 2011-06-16 | Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SMT201600398B true SMT201600398B (it) | 2017-01-10 |
Family
ID=47357651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SM201600398T SMT201600398B (it) | 2011-06-16 | 2016-11-07 | Inibitori di proteina chinasi (varianti), uso di questi nel trattamento di malattie oncologiche e composizione farmaceutica basata su questi |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9522910B2 (it) |
| EP (1) | EP2743266B8 (it) |
| AU (1) | AU2012269818B2 (it) |
| CA (1) | CA2850137C (it) |
| CY (1) | CY1118513T1 (it) |
| DK (1) | DK2743266T3 (it) |
| EA (1) | EA026704B1 (it) |
| ES (1) | ES2602797T3 (it) |
| HR (1) | HRP20161478T1 (it) |
| HU (1) | HUE031837T2 (it) |
| IL (1) | IL232357A (it) |
| IN (1) | IN2014MN00635A (it) |
| LT (1) | LT2743266T (it) |
| PL (1) | PL2743266T3 (it) |
| PT (1) | PT2743266T (it) |
| RS (1) | RS55380B1 (it) |
| RU (1) | RU2477723C2 (it) |
| SI (1) | SI2743266T1 (it) |
| SM (1) | SMT201600398B (it) |
| UA (1) | UA115228C2 (it) |
| WO (1) | WO2012173521A2 (it) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2918588T3 (en) | 2010-05-20 | 2017-08-28 | Array Biopharma Inc | Macrocyclic compounds as TRK kinase inhibitors |
| WO2013170774A1 (zh) * | 2012-05-16 | 2013-11-21 | 上海医药集团股份有限公司 | 具有抗肿瘤活性的乙炔衍生物 |
| US8859553B2 (en) * | 2012-07-30 | 2014-10-14 | Astar Biotech Llc | Protein kinase inhibitors |
| CN103664787B (zh) * | 2012-09-17 | 2015-09-09 | 南京圣和药业股份有限公司 | 炔杂芳环化合物及其应用 |
| CN104341416B (zh) * | 2013-07-31 | 2017-03-29 | 南京圣和药业股份有限公司 | 蛋白酪氨酸激酶抑制剂及其应用 |
| US10172839B2 (en) | 2014-03-06 | 2019-01-08 | University Of Southern California | Use of short term starvation regimen in combination with kinase inhibitors to enhance traditional chemo-drug efficacy and feasibility and reverse side effects of kinases in normal cells and tissues |
| KR20160127076A (ko) * | 2014-03-06 | 2016-11-02 | 유니버시티 오브 써던 캘리포니아 | 전통적인 화학 요법-약물 효능 및 유용성을 강화시키고 정상 세포와 조직에서 키나제의 부작용을 반전시키기 위한 키나제 억제제와 조합된 단기 기아 요법의 사용 |
| AR104259A1 (es) | 2015-04-15 | 2017-07-05 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
| CN106146391A (zh) * | 2015-04-15 | 2016-11-23 | 中国科学院上海药物研究所 | 5-芳香炔基取代的苯甲酰胺类化合物及其制备方法、药物组合物和用途 |
| EA035049B1 (ru) | 2015-07-16 | 2020-04-22 | Аррэй Байофарма Инк. | СОЕДИНЕНИЯ ЗАМЕЩЕННОГО ПИРАЗОЛО[1,5-a]ПИРИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ RET КИНАЗЫ |
| RU2652992C2 (ru) | 2016-04-18 | 2018-05-04 | Общество С Ограниченной Ответственностью "Фьюжн Фарма" | Новая кристаллическая солевая форма 3-(1,2,4-триазоло[4,3-а]пиридин-3-илэтинил)-4-метил-n-(4-((4-метилпиперазин-1-ил)метил)-3-трифторметилфенил)бензамида для медицинского применения |
| JOP20190077A1 (ar) | 2016-10-10 | 2019-04-09 | Array Biopharma Inc | مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret |
| TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| US11168090B2 (en) | 2017-01-18 | 2021-11-09 | Array Biopharma Inc. | Substituted pyrazolo[1,5-a]pyrazines as RET kinase inhibitors |
| WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
| TWI876442B (zh) | 2017-10-10 | 2025-03-11 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
| RU2664420C1 (ru) * | 2017-10-31 | 2018-08-17 | Общество С Ограниченной Ответственностью "Фьюжн Фарма" | ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ДОЗИРОВКА И СПОСОБ ЛЕЧЕНИЯ Ph+ ЛЕЙКЕМИЙ |
| US11472802B2 (en) | 2018-01-18 | 2022-10-18 | Array Biopharma Inc. | Substituted pyrazolyl[4,3-c]pyridine compounds as RET kinase inhibitors |
| WO2019143991A1 (en) | 2018-01-18 | 2019-07-25 | Array Biopharma Inc. | SUBSTITUTED PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS AS RET KINASE INHIBITORS |
| CN111971286B (zh) | 2018-01-18 | 2023-04-14 | 阿雷生物药品公司 | 作为RET激酶抑制剂的取代的吡咯并[2,3-d]嘧啶化合物 |
| JP2022500383A (ja) | 2018-09-10 | 2022-01-04 | アレイ バイオファーマ インコーポレイテッド | Ｒｅｔキナーゼ阻害剤としての縮合複素環式化合物 |
| EP3873893A1 (en) * | 2018-11-02 | 2021-09-08 | Merck Sharp & Dohme Corp. | 2-amino-n-heteroaryl-nicotinamides as nav1.8 inhibitors |
| WO2022015051A1 (ko) * | 2020-07-14 | 2022-01-20 | 주식회사 보로노이바이오 | 아릴 또는 헤테로아릴 유도체, 및 이를 유효성분으로 포함하는 키나아제 관련 질환 예방 또는 치료용 약학적 조성물 |
| GB202209210D0 (en) * | 2022-06-23 | 2022-08-10 | Univ Strathclyde | Cycloaddition reactions |
| CN116217571B (zh) * | 2023-03-28 | 2024-11-15 | 上海锐谱医药科技有限公司 | 一种制备药物砌块1,2,4-三唑并[4,3-a]吡啶-3-胺的方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4105947B2 (ja) | 2000-09-15 | 2008-06-25 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼインヒビターとして有用なトリアゾール化合物 |
| RU2340611C2 (ru) * | 2000-09-15 | 2008-12-10 | Вертекс Фармасьютикалз Инкорпорейтед | Производные пиразола, используемые в качестве ингибиторов протеинкиназы |
| US7709520B2 (en) | 2000-10-06 | 2010-05-04 | The Texas A&M University System | Diindolylmethane and C-substituted diindolylmethane compositions and methods for the treatment of multiple cancers |
| US7435823B2 (en) | 2004-01-23 | 2008-10-14 | Amgen Inc. | Compounds and methods of use |
| TW200610762A (en) | 2004-06-10 | 2006-04-01 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| WO2007002248A2 (en) | 2005-06-24 | 2007-01-04 | Merck & Co., Inc. | Modified malonate derivatives |
| PT1973545E (pt) * | 2005-12-23 | 2013-02-11 | Ariad Pharma Inc | Compostos de heteroarilo bicíclicos |
| JP2009526855A (ja) | 2006-02-16 | 2009-07-23 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | アルファカルボリンおよびその使用 |
| CA2651822A1 (en) * | 2006-05-08 | 2007-11-22 | Ariad Pharmaceuticals, Inc. | Acetylenic heteroaryl compounds |
| ES2413087T3 (es) | 2006-06-13 | 2013-07-15 | Oncomed Pharmaceuticals, Inc. | Composiciones y métodos para el diagnóstico y tratamiento del cáncer |
| US7612085B2 (en) | 2006-07-11 | 2009-11-03 | Washington University | Sigma 2 receptor ligands and therapeutic uses therefor |
| EP2125683B1 (en) | 2006-12-19 | 2013-10-23 | The Board of Trustees of the University of Illinois | 3-benzofuranyl-4-indolyl-maleimides as potent gsk-3 inhibitors for neurodegenerative disorders |
| JP2010531304A (ja) | 2007-06-18 | 2010-09-24 | ユニバーシティ オブ ルイビル リサーチ ファウンデーション、インコーポレイテッド | 抗悪性腫瘍活性を有するｐｆｋｆｂ３阻害物質ファミリー |
| JP5314050B2 (ja) | 2008-01-23 | 2013-10-16 | ブリストル−マイヤーズ スクイブ カンパニー | ４−ピリジノン化合物および癌についてのその使用 |
| US8211911B2 (en) | 2008-08-19 | 2012-07-03 | Guoqing Paul Chen | Compounds as kinase inhibitors |
| US8188109B2 (en) | 2009-07-20 | 2012-05-29 | Naxospharma S.R.L. | Benzoquinolizinium salt derivatives as anticancer agents |
| US8242282B2 (en) | 2010-05-18 | 2012-08-14 | Taipei Medical University | Histone deacetylase inhibitors |
| RU2011113236A (ru) | 2011-04-07 | 2012-10-20 | Общество с ограниченной ответственностью "Фьюжн Фарма" (RU) | Новые химические соединения для лечения онкологических заболеваний |
| WO2013170774A1 (zh) | 2012-05-16 | 2013-11-21 | 上海医药集团股份有限公司 | 具有抗肿瘤活性的乙炔衍生物 |
| US8859553B2 (en) | 2012-07-30 | 2014-10-14 | Astar Biotech Llc | Protein kinase inhibitors |
-
2011
- 2011-06-16 RU RU2011124304/04A patent/RU2477723C2/ru active IP Right Revival
-
2012
- 2012-05-29 AU AU2012269818A patent/AU2012269818B2/en active Active
- 2012-05-29 ES ES12801171.5T patent/ES2602797T3/es active Active
- 2012-05-29 IN IN635MUN2014 patent/IN2014MN00635A/en unknown
- 2012-05-29 HU HUE12801171A patent/HUE031837T2/en unknown
- 2012-05-29 HR HRP20161478TT patent/HRP20161478T1/hr unknown
- 2012-05-29 CA CA2850137A patent/CA2850137C/en active Active
- 2012-05-29 LT LTEP12801171.5T patent/LT2743266T/lt unknown
- 2012-05-29 SI SI201230763A patent/SI2743266T1/en unknown
- 2012-05-29 PL PL12801171T patent/PL2743266T3/pl unknown
- 2012-05-29 DK DK12801171.5T patent/DK2743266T3/en active
- 2012-05-29 RS RS20160956A patent/RS55380B1/sr unknown
- 2012-05-29 WO PCT/RU2012/000423 patent/WO2012173521A2/ru active Application Filing
- 2012-05-29 EA EA201491356A patent/EA026704B1/ru unknown
- 2012-05-29 PT PT128011715T patent/PT2743266T/pt unknown
- 2012-05-29 UA UAA201404861A patent/UA115228C2/uk unknown
- 2012-05-29 EP EP12801171.5A patent/EP2743266B8/en active Active
-
2014
- 2014-04-01 US US14/242,241 patent/US9522910B2/en active Active
- 2014-04-29 IL IL232357A patent/IL232357A/en active IP Right Grant
-
2016
- 2016-11-07 SM SM201600398T patent/SMT201600398B/it unknown
- 2016-11-16 CY CY20161101178T patent/CY1118513T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2743266A4 (en) | 2015-03-11 |
| IL232357A0 (en) | 2014-07-01 |
| AU2012269818A1 (en) | 2014-06-26 |
| PT2743266T (pt) | 2016-10-14 |
| WO2012173521A2 (ru) | 2012-12-20 |
| IL232357A (en) | 2017-05-29 |
| RS55380B1 (sr) | 2017-03-31 |
| US9522910B2 (en) | 2016-12-20 |
| EP2743266A2 (en) | 2014-06-18 |
| WO2012173521A3 (ru) | 2013-03-28 |
| RU2477723C2 (ru) | 2013-03-20 |
| HRP20161478T1 (hr) | 2016-12-16 |
| IN2014MN00635A (it) | 2015-07-03 |
| US20140213592A1 (en) | 2014-07-31 |
| PL2743266T3 (pl) | 2017-02-28 |
| UA115228C2 (uk) | 2017-10-10 |
| CY1118513T1 (el) | 2017-07-12 |
| CA2850137A1 (en) | 2012-12-20 |
| CA2850137C (en) | 2016-10-25 |
| LT2743266T (lt) | 2016-12-12 |
| HUE031837T2 (en) | 2017-08-28 |
| EP2743266B8 (en) | 2016-09-28 |
| AU2012269818B2 (en) | 2016-05-19 |
| EP2743266B1 (en) | 2016-08-17 |
| ES2602797T3 (es) | 2017-02-22 |
| RU2011124304A (ru) | 2012-12-27 |
| HK1195771A1 (en) | 2014-11-21 |
| DK2743266T3 (en) | 2016-12-05 |
| EA026704B1 (ru) | 2017-05-31 |
| SI2743266T1 (en) | 2017-02-28 |
| EA201491356A1 (ru) | 2015-01-30 |
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