SMT201400023B - Analoghi di buprenorfina - Google Patents

Analoghi di buprenorfina

Info

Publication number: SMT201400023B
Authority: SM; San Marino
Prior art keywords: buprenorphine; analogs
Prior art date: 2008-07-30

Application number

SM201400023T

Other languages

English (en)

Inventor

Donald J Kyle

Richard R Goehring

Marian E Fundytus

Original Assignee

Purdue Pharma Lp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-07-30

Filing date

2014-02-19

Publication date

2014-05-07

2014-02-19 Application filed by Purdue Pharma Lp filed Critical Purdue Pharma Lp

2014-05-07 Publication of SMT201400023B publication Critical patent/SMT201400023B/it

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
- C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
- C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)

SM201400023T 2008-07-30 2014-02-19 Analoghi di buprenorfina SMT201400023B (it)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US8476408P	2008-07-30	2008-07-30
US22611909P	2009-07-16	2009-07-16
PCT/US2009/004391 WO2010014229A1 (en)	2008-07-30	2009-07-30	Buprenorphine analogs

Publications (1)

Publication Number	Publication Date
SMT201400023B true SMT201400023B (it)	2014-05-07

Family

ID=41119539

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SM201400023T SMT201400023B (it)	2008-07-30	2014-02-19	Analoghi di buprenorfina

Country Status (24)

Country	Link
US (1)	US8530494B2 (it)
EP (2)	EP2703404A1 (it)
JP (2)	JP5525524B2 (it)
KR (1)	KR101343395B1 (it)
CN (2)	CN103450206A (it)
AU (1)	AU2009277095B2 (it)
CA (1)	CA2731939C (it)
CO (1)	CO6341635A2 (it)
DK (1)	DK2326651T3 (it)
ES (1)	ES2449222T3 (it)
HR (1)	HRP20140182T1 (it)
IL (1)	IL210391A0 (it)
ME (1)	ME01665B (it)
MX (1)	MX2011001268A (it)
NZ (1)	NZ590650A (it)
PL (1)	PL2326651T3 (it)
PT (1)	PT2326651E (it)
RS (1)	RS53154B (it)
RU (2)	RU2520222C2 (it)
SI (1)	SI2326651T1 (it)
SM (1)	SMT201400023B (it)
UA (1)	UA104004C2 (it)
WO (1)	WO2010014229A1 (it)
ZA (1)	ZA201100188B (it)

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KR20150027315A (ko) *	2010-09-21	2015-03-11	퍼듀 퍼머 엘피	부프레노르핀 유사체
FR2975912B1 (fr)	2011-05-30	2013-06-14	Flamel Tech Sa	Composition a liberation controlee de buprenorphine
EP2788358B1 (en) *	2011-12-08	2018-08-29	Purdue Pharma LP	Quaternized buprenorphine analogs
WO2014072809A2 (en)	2012-11-09	2014-05-15	Purdue Pharma L.P.	Benzomorphan analogs and the use thereof
JP6317755B2 (ja) *	2012-12-07	2018-04-25	パーデュー、ファーマ、リミテッド、パートナーシップ	オピオイド受容体モジュレーターとしてのブプレノルフィン類似体
JP6100917B2 (ja)	2012-12-14	2017-03-22	パーデュー、ファーマ、リミテッド、パートナーシップ	ピリドンモルフィナン類似体およびオピオイド受容体に対する生物活性
EP2931726B1 (en)	2012-12-14	2017-01-25	Purdue Pharma LP	Spirocyclic morphinans and their use
ES2653265T3 (es) *	2012-12-28	2018-02-06	Purdue Pharma Lp	Morfinanos sustituidos y el uso de éstos
WO2014118618A1 (en)	2013-01-31	2014-08-07	Purdue Pharma L.P.	Benzomorphan analogs and the use thereof
US8969358B2 (en)	2013-03-15	2015-03-03	Purdue Pharma L.P.	Buprenorphine analogs
US20160333020A1 (en) *	2013-12-26	2016-11-17	Purdue Pharma L.P.	7-beta analogs of orvinols
WO2015097547A1 (en)	2013-12-26	2015-07-02	Purdue Pharma L.P.	10-substituted morphinan hydantoins
WO2015097545A1 (en)	2013-12-26	2015-07-02	Purdue Pharma L.P.	Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans
EP3087078B1 (en) *	2013-12-26	2019-05-15	Purdue Pharma LP	7-beta-alkyl analogs of orvinols
US9340542B2 (en)	2013-12-26	2016-05-17	Purdue Pharma L.P.	Propellane-based compounds and the use thereof
JP6353543B2 (ja)	2013-12-26	2018-07-04	パーデュー、ファーマ、リミテッド、パートナーシップ	環縮小モルフィナン及びその使用
WO2015099863A1 (en)	2013-12-27	2015-07-02	Purdue Pharma L.P.	6-substituted and 7-substituted morphinan analogs and the use thereof
US10030021B2 (en)	2014-05-27	2018-07-24	Purdue Pharma L.P.	Spirocyclic morphinans and use thereof
JP6360915B2 (ja)	2014-06-13	2018-07-18	パーデュー、ファーマ、リミテッド、パートナーシップ	アザモルフィナン誘導体及びその使用
TW201607923A (zh)	2014-07-15	2016-03-01	歌林達有限公司	被取代之氮螺環（４．５）癸烷衍生物
MA41125A (fr)	2014-12-05	2017-10-10	Purdue Pharma Lp	Dérivés de 6.7-cyclomorphinane et leur utilisation
WO2018125716A1 (en)	2017-01-02	2018-07-05	Purdue Pharma L.P.	Morphinan derivatives and use thereof

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2009
- 2009-07-30 UA UAA201102272A patent/UA104004C2/uk unknown
- 2009-07-30 EP EP13193016.6A patent/EP2703404A1/en not_active Withdrawn
- 2009-07-30 ME MEP-2014-12A patent/ME01665B/me unknown
- 2009-07-30 RU RU2011107440/04A patent/RU2520222C2/ru not_active IP Right Cessation
- 2009-07-30 US US13/055,873 patent/US8530494B2/en active Active
- 2009-07-30 RS RS20140044A patent/RS53154B/en unknown
- 2009-07-30 MX MX2011001268A patent/MX2011001268A/es active IP Right Grant
- 2009-07-30 ES ES09789036.2T patent/ES2449222T3/es active Active
- 2009-07-30 NZ NZ590650A patent/NZ590650A/xx not_active IP Right Cessation
- 2009-07-30 PT PT97890362T patent/PT2326651E/pt unknown
- 2009-07-30 WO PCT/US2009/004391 patent/WO2010014229A1/en active Application Filing
- 2009-07-30 SI SI200930838T patent/SI2326651T1/sl unknown
- 2009-07-30 EP EP09789036.2A patent/EP2326651B1/en active Active
- 2009-07-30 CN CN2013103061017A patent/CN103450206A/zh active Pending
- 2009-07-30 DK DK09789036.2T patent/DK2326651T3/da active
- 2009-07-30 JP JP2011521121A patent/JP5525524B2/ja not_active Expired - Fee Related
- 2009-07-30 CN CN200980129395.2A patent/CN102112479B/zh not_active Expired - Fee Related
- 2009-07-30 HR HRP20140182AT patent/HRP20140182T1/hr unknown
- 2009-07-30 AU AU2009277095A patent/AU2009277095B2/en not_active Ceased
- 2009-07-30 CA CA2731939A patent/CA2731939C/en not_active Expired - Fee Related
- 2009-07-30 KR KR1020117004830A patent/KR101343395B1/ko not_active Expired - Fee Related
- 2009-07-30 PL PL09789036T patent/PL2326651T3/pl unknown
2010
- 2010-12-30 IL IL210391A patent/IL210391A0/en not_active IP Right Cessation
2011
- 2011-01-06 ZA ZA2011/00188A patent/ZA201100188B/en unknown
- 2011-02-28 CO CO11023774A patent/CO6341635A2/es not_active Application Discontinuation
2013
- 2013-02-18 RU RU2013106944/04A patent/RU2013106944A/ru not_active Application Discontinuation
2014
- 2014-02-19 SM SM201400023T patent/SMT201400023B/it unknown
- 2014-04-11 JP JP2014081697A patent/JP2014208640A/ja active Pending

Also Published As

Publication number	Publication date
ZA201100188B (en)	2011-09-28
WO2010014229A1 (en)	2010-02-04
JP5525524B2 (ja)	2014-06-18
AU2009277095A1 (en)	2010-02-04
CA2731939C (en)	2017-05-23
PL2326651T3 (pl)	2014-05-30
KR20110036859A (ko)	2011-04-11
UA104004C2 (uk)	2013-12-25
RS53154B (en)	2014-06-30
EP2326651B1 (en)	2013-11-27
DK2326651T3 (da)	2014-01-20
ES2449222T3 (es)	2014-03-18
JP2012506839A (ja)	2012-03-22
EP2326651A1 (en)	2011-06-01
US20110136846A1 (en)	2011-06-09
CO6341635A2 (es)	2011-11-21
HRP20140182T1 (hr)	2014-04-11
IL210391A0 (en)	2011-03-31
US8530494B2 (en)	2013-09-10
KR101343395B1 (ko)	2013-12-19
RU2013106944A (ru)	2014-08-27
MX2011001268A (es)	2011-07-29
CA2731939A1 (en)	2010-02-04
JP2014208640A (ja)	2014-11-06
HK1158622A1 (en)	2012-07-20
SI2326651T1 (sl)	2014-03-31
NZ590650A (en)	2013-01-25
RU2011107440A (ru)	2012-09-10
AU2009277095B2 (en)	2012-09-06
EP2703404A1 (en)	2014-03-05
CN103450206A (zh)	2013-12-18
CN102112479B (zh)	2014-10-29
RU2520222C2 (ru)	2014-06-20
CN102112479A (zh)	2011-06-29
ME01665B (me)	2014-09-20
PT2326651E (pt)	2014-02-12

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CY2017026I1 (el)	2017-11-14	Τετρακυκλικη ενωση
SMT201600008B (it)	2016-02-25	Composti di piridazinone
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DK2427449T3 (da)	2013-04-22	Vinylindazolylforbindelser
BR112012006859A2 (pt)	2019-09-24	compostos
DOP2012000114A (es)	2012-08-15	Inhibidor bromodominio de benzodiazepina
FR2941462B1 (fr)	2013-07-05	Composition decapante
EP2332698A4 (en)	2012-01-04	ROBOT HAND
BRPI1013614A2 (pt)	2019-09-24	compostos substituídos de espiro-amida
EP2563771A4 (en)	2013-11-06	METALLOENZYMHEMMERVERBINDUNGEN
SMT201600458B (it)	2017-03-08	Composizioni comprendenti buprenorfina
BR112013003753A2 (pt)	2016-05-31	compostos
EP2380713A4 (en)	2014-01-22	ROBOT HAND
BRPI1005525A2 (pt)	2016-02-23	compostos de azaazuleno
BRPI1013868A2 (pt)	2016-04-05	composto diaciletilenodiamina
EP2383082A4 (en)	2014-06-04	ROBOT HAND
HRP20150167T1 (xx)	2015-05-22	Spojevi kao antagonisti bradikinina-b1
BRPI0910345A2 (pt)	2015-10-06	análogos de oxitocina
UY33156A (es)	2011-07-29	Nuevos compuestos tienopirrol
PT2626350E (pt)	2015-08-03	Composto de ciclopropano
SMT201500268B (it)	2016-01-08	Derivato di 5-idrossipirimidin-4-carbossammide
DK2453858T3 (da)	2014-11-03	Fremgangsmåde
SMT201500156B (it)	2015-09-07	Composti di diidropirrolonaftiridinione come inibitori di jak