SK495A3 - Detection method of antibodies of hepatitis virus and set for detection of antibodies hcv - Google Patents
Detection method of antibodies of hepatitis virus and set for detection of antibodies hcvInfo
- Publication number
- SK495A3 SK495A3 SK4-95A SK495A SK495A3 SK 495 A3 SK495 A3 SK 495A3 SK 495 A SK495 A SK 495A SK 495 A3 SK495 A3 SK 495A3
- Authority
- SK
- Slovakia
- Prior art keywords
- antibodies
- hcv
- antigens
- detection
- conformational epitopes
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
- G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Communicable Diseases (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Immunoassay methods utilizing HCV envelope antigens that contain conformational epitopes reactive with antibodies in serum from infected individuals are useful for screening and diagnosis. These antigens detect antibodies that are not detected by denatured HCV envelope antigens. In addition, these HCV envelope antigens comprised of conformational epitopes are more immunologically reactive than a number of other HCV antigens. This is the first evidence that conformational epitopes may be involved in the immunologic response to HCV antigens.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91075992A | 1992-07-07 | 1992-07-07 | |
| PCT/US1993/006309 WO1994001778A1 (en) | 1992-07-07 | 1993-07-02 | Immunoassays for anti-hcv antibodies using antigens with conformational epitopes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK495A3 true SK495A3 (en) | 1995-07-11 |
| SK284556B6 SK284556B6 (en) | 2005-06-02 |
Family
ID=25429280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK4-95A SK284556B6 (en) | 1992-07-07 | 1993-07-02 | A method for detecting early seroconversion with hepatitis C virus and a kit for use in the method |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20020150883A1 (en) |
| EP (1) | EP0649537B2 (en) |
| JP (2) | JP3490085B2 (en) |
| AT (1) | ATE216779T1 (en) |
| AU (1) | AU685059B2 (en) |
| CA (1) | CA2139645C (en) |
| CZ (1) | CZ291951B6 (en) |
| DE (1) | DE69331845T3 (en) |
| DK (1) | DK0649537T4 (en) |
| ES (1) | ES2171414T5 (en) |
| FI (1) | FI110546B (en) |
| HU (1) | HUT70473A (en) |
| NO (1) | NO321185B1 (en) |
| PL (1) | PL174686B1 (en) |
| PT (1) | PT649537E (en) |
| RU (1) | RU2126158C1 (en) |
| SK (1) | SK284556B6 (en) |
| UA (1) | UA39944C2 (en) |
| WO (1) | WO1994001778A1 (en) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6274148B1 (en) * | 1990-11-08 | 2001-08-14 | Chiron Corporation | Hepatitis C virus asialoglycoproteins |
| US7070790B1 (en) | 1993-06-29 | 2006-07-04 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleotide and deduced amino acid sequences of the envelope 1 and core genes of isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines |
| US5882852A (en) * | 1993-06-29 | 1999-03-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Hepatitic C virus (HCV) core gene nucleotide sequences and related methods of detecting major and minor genotypes of HCV isolates |
| EP0721505B2 (en) | 1994-07-29 | 2006-05-10 | Innogenetics N.V. | Purified hepatitis c virus envelope proteins for diagnostic and therapeutic use |
| DE4428705A1 (en) * | 1994-08-12 | 1996-02-15 | Boehringer Mannheim Gmbh | Recombinant antigen from the NS3 region of the hepatitis C virus |
| US5707385A (en) * | 1994-11-16 | 1998-01-13 | Advanced Cardiovascular Systems, Inc. | Drug loaded elastic membrane and method for delivery |
| EP0836708A1 (en) * | 1995-06-07 | 1998-04-22 | Abbott Laboratories | Method for antibody to hepatitis c virus second envelope glycoprotein |
| US6514731B1 (en) | 1996-05-24 | 2003-02-04 | Chiron Corporation | Methods for the preparation of hepatitis C virus multiple copy epitope fusion antigens |
| WO2000026673A1 (en) * | 1998-11-03 | 2000-05-11 | Abbott Laboratories | Methods of detecting chronic infection caused by hcv |
| WO2001009609A2 (en) * | 1999-07-28 | 2001-02-08 | Chiron Corporation | Hepatitis c viral antigen immunoassay detection systems |
| US6815160B1 (en) | 1999-07-28 | 2004-11-09 | Chiron Corporation | Hepatitis C viral antigen immunoassay detection systems |
| EP1829891B1 (en) | 2000-06-15 | 2012-12-26 | Novartis Vaccines and Diagnostics, Inc. | Immunoassays for Anti-HCV Antibodies |
| DE60129598T2 (en) | 2000-06-15 | 2008-04-17 | Novartis Vaccines and Diagnostics, Inc., Emeryville | Immunoassays for anti-HCV antibodies |
| AR045702A1 (en) | 2001-10-03 | 2005-11-09 | Chiron Corp | COMPOSITIONS OF ASSISTANTS. |
| US7166426B2 (en) | 2002-09-09 | 2007-01-23 | Novartis Vaccines And Diagnostics, Inc. | HCV assay |
| WO2004071414A2 (en) * | 2003-02-05 | 2004-08-26 | Genzyme Corporation | Therapeutic anti-hcv (al9) compounds |
| US7731967B2 (en) | 2003-04-30 | 2010-06-08 | Novartis Vaccines And Diagnostics, Inc. | Compositions for inducing immune responses |
| ATE542140T1 (en) | 2004-08-27 | 2012-02-15 | Novartis Vaccines & Diagnostic | NON-STRUCTURAL HCV PROTEIN MUTANTS AND POSSIBLE USES THEREOF |
| WO2008024518A2 (en) | 2006-08-25 | 2008-02-28 | Novartis Ag | Hcv fusion polypeptides |
| ES2664753T3 (en) | 2007-12-07 | 2018-04-23 | Glaxosmithkline Biologicals Sa | Immune response induction compositions |
| FR2984328B1 (en) | 2011-12-20 | 2016-12-30 | Bio-Rad Innovations | METHOD FOR DETECTING HEPATITIS C VIRUS INFECTION |
| CA2906407A1 (en) | 2013-03-14 | 2014-09-18 | Abbott Laboratories | Hcv ns3 recombinant antigens and mutants thereof for improved antibody detection |
| US9194873B2 (en) | 2013-03-14 | 2015-11-24 | Abbott Laboratories | HCV antigen-antibody combination assay and methods and compositions for use therein |
| WO2014143343A1 (en) | 2013-03-14 | 2014-09-18 | Abbott Laboratories | Hcv core lipid binding domain monoclonal antibodies |
| WO2016160046A1 (en) | 2015-03-27 | 2016-10-06 | Ortho-Clinical Diagnostics, Inc. | Hcv ns4a/modified ns3 polypeptides and uses thereof |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4855224A (en) * | 1984-03-09 | 1989-08-08 | Genentech, Inc. | Molecularly cloned diagnostic product and method of use |
| NZ227011A (en) | 1987-11-18 | 1992-03-26 | Chiron Corp | Non-a, non-b-hepatitis (hepatitis c) antigens, proteins, nucleotide sequences, vaccines and kits |
| JP2656995B2 (en) | 1989-03-17 | 1997-09-24 | カイロン コーポレイション | NANBV diagnostics |
| US5372928A (en) * | 1989-09-15 | 1994-12-13 | Chiron Corporation | Hepatitis C virus isolates |
| FI906208L (en) * | 1989-12-18 | 1991-06-19 | Wellcome Found | OFFICIALLY YESTERDAY. |
| ZA912040B (en) * | 1990-03-30 | 1991-12-24 | Akzo Nv | Peptides immunochemically reactive with antibodies directed against hepatitis non-a,non-b virus |
| HU217025B (en) * | 1990-04-04 | 1999-11-29 | Chiron Corp. | Hepatitis C virus (HCV) antigen preparations for detecting anti-HCV antibodies in immunoassays |
| KR100217483B1 (en) * | 1990-04-06 | 1999-09-01 | 프랭크 쿵 | Hepatitis C Virus Epitope |
| NZ238681A (en) * | 1990-06-25 | 1992-03-26 | Univ Osaka Res Found | Non-a, non-b hepatitis virus particles and their production |
| EP0468657A3 (en) * | 1990-07-09 | 1992-02-05 | Tonen Corporation | Non-a non b hepatitis-specific antigen and its use in hepatitus diagnosis |
| DK0842947T4 (en) * | 1990-11-08 | 2009-06-08 | Novartis Vaccines & Diagnostic | Hepatitis C virus asialoglycoproteins |
| IT1249684B (en) * | 1991-07-19 | 1995-03-09 | Sorin Biomedica Spa | HEPATITIS VIRUS PROTEIN ENV EPITOPES |
| DE69333269T2 (en) * | 1992-01-31 | 2004-07-29 | Abbott Laboratories, Abbott Park | EXPRESSION SYSTEM IN MAMMALS FOR HCV PROTEINS |
| US5587285A (en) * | 1992-01-31 | 1996-12-24 | University Of Texas System | Generation serological assay for monitoring HIV exposure |
-
1993
- 1993-02-07 UA UA95028108A patent/UA39944C2/en unknown
- 1993-07-02 AU AU46629/93A patent/AU685059B2/en not_active Expired
- 1993-07-02 HU HU9500008A patent/HUT70473A/en not_active Application Discontinuation
- 1993-07-02 ES ES93916942T patent/ES2171414T5/en not_active Expired - Lifetime
- 1993-07-02 SK SK4-95A patent/SK284556B6/en not_active IP Right Cessation
- 1993-07-02 PT PT93916942T patent/PT649537E/en unknown
- 1993-07-02 DE DE69331845T patent/DE69331845T3/en not_active Expired - Lifetime
- 1993-07-02 CA CA002139645A patent/CA2139645C/en not_active Expired - Lifetime
- 1993-07-02 JP JP50344094A patent/JP3490085B2/en not_active Expired - Lifetime
- 1993-07-02 PL PL93307178A patent/PL174686B1/en unknown
- 1993-07-02 AT AT93916942T patent/ATE216779T1/en active
- 1993-07-02 EP EP93916942A patent/EP0649537B2/en not_active Expired - Lifetime
- 1993-07-02 WO PCT/US1993/006309 patent/WO1994001778A1/en active IP Right Grant
- 1993-07-02 RU RU94046284A patent/RU2126158C1/en active
- 1993-07-02 DK DK93916942T patent/DK0649537T4/en active
- 1993-07-02 CZ CZ19956A patent/CZ291951B6/en not_active IP Right Cessation
-
1995
- 1995-01-02 FI FI950002A patent/FI110546B/en not_active IP Right Cessation
- 1995-01-02 NO NO19950006A patent/NO321185B1/en not_active IP Right Cessation
-
2001
- 2001-08-02 US US09/920,879 patent/US20020150883A1/en not_active Abandoned
-
2003
- 2003-04-14 JP JP2003109573A patent/JP2003329687A/en not_active Withdrawn
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK4A | Patent expired |
Expiry date: 20130702 |