DE69331845D1 - IMMUNOASSAYS FOR ANTI-HCV ANTIBODIES USING ANTIGENS WITH INFORMATION SEPITOPES - Google Patents
IMMUNOASSAYS FOR ANTI-HCV ANTIBODIES USING ANTIGENS WITH INFORMATION SEPITOPESInfo
- Publication number
- DE69331845D1 DE69331845D1 DE69331845T DE69331845T DE69331845D1 DE 69331845 D1 DE69331845 D1 DE 69331845D1 DE 69331845 T DE69331845 T DE 69331845T DE 69331845 T DE69331845 T DE 69331845T DE 69331845 D1 DE69331845 D1 DE 69331845D1
- Authority
- DE
- Germany
- Prior art keywords
- antigens
- hcv
- sepitopes
- immunoassays
- information
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
- G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Communicable Diseases (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Immunoassay methods utilizing HCV envelope antigens that contain conformational epitopes reactive with antibodies in serum from infected individuals are useful for screening and diagnosis. These antigens detect antibodies that are not detected by denatured HCV envelope antigens. In addition, these HCV envelope antigens comprised of conformational epitopes are more immunologically reactive than a number of other HCV antigens. This is the first evidence that conformational epitopes may be involved in the immunologic response to HCV antigens.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91075992A | 1992-07-07 | 1992-07-07 | |
| US910759 | 1992-07-07 | ||
| PCT/US1993/006309 WO1994001778A1 (en) | 1992-07-07 | 1993-07-02 | Immunoassays for anti-hcv antibodies using antigens with conformational epitopes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE69331845D1 true DE69331845D1 (en) | 2002-06-06 |
| DE69331845T2 DE69331845T2 (en) | 2002-08-14 |
| DE69331845T3 DE69331845T3 (en) | 2006-10-05 |
Family
ID=25429280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69331845T Expired - Lifetime DE69331845T3 (en) | 1992-07-07 | 1993-07-02 | IMMUNOASSAYS FOR ANTI-HCV ANTIBODIES USING ANTIGENES WITH CONFORMATION SAMPLES |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20020150883A1 (en) |
| EP (1) | EP0649537B2 (en) |
| JP (2) | JP3490085B2 (en) |
| AT (1) | ATE216779T1 (en) |
| AU (1) | AU685059B2 (en) |
| CA (1) | CA2139645C (en) |
| CZ (1) | CZ291951B6 (en) |
| DE (1) | DE69331845T3 (en) |
| DK (1) | DK0649537T4 (en) |
| ES (1) | ES2171414T5 (en) |
| FI (1) | FI110546B (en) |
| HU (1) | HUT70473A (en) |
| NO (1) | NO321185B1 (en) |
| PL (1) | PL174686B1 (en) |
| PT (1) | PT649537E (en) |
| RU (1) | RU2126158C1 (en) |
| SK (1) | SK284556B6 (en) |
| UA (1) | UA39944C2 (en) |
| WO (1) | WO1994001778A1 (en) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6274148B1 (en) * | 1990-11-08 | 2001-08-14 | Chiron Corporation | Hepatitis C virus asialoglycoproteins |
| US5882852A (en) * | 1993-06-29 | 1999-03-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Hepatitic C virus (HCV) core gene nucleotide sequences and related methods of detecting major and minor genotypes of HCV isolates |
| US7070790B1 (en) | 1993-06-29 | 2006-07-04 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleotide and deduced amino acid sequences of the envelope 1 and core genes of isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines |
| ES2174957T5 (en) | 1994-07-29 | 2006-12-16 | Innogenetics N.V. | PURIFIED PROTEINS OF HEPATITIS C VIRUS WRAPPING FOR DIAGNOSTIC AND THERAPEUTIC USE. |
| DE4428705A1 (en) * | 1994-08-12 | 1996-02-15 | Boehringer Mannheim Gmbh | Recombinant antigen from the NS3 region of the hepatitis C virus |
| US5707385A (en) * | 1994-11-16 | 1998-01-13 | Advanced Cardiovascular Systems, Inc. | Drug loaded elastic membrane and method for delivery |
| WO1996041196A1 (en) * | 1995-06-07 | 1996-12-19 | Abbott Laboratories | Method for detection of antibody to hepatitis c virus second envelope glycoprotein |
| US6514731B1 (en) | 1996-05-24 | 2003-02-04 | Chiron Corporation | Methods for the preparation of hepatitis C virus multiple copy epitope fusion antigens |
| WO2000026673A1 (en) * | 1998-11-03 | 2000-05-11 | Abbott Laboratories | Methods of detecting chronic infection caused by hcv |
| US6815160B1 (en) | 1999-07-28 | 2004-11-09 | Chiron Corporation | Hepatitis C viral antigen immunoassay detection systems |
| EP1295126B1 (en) * | 1999-07-28 | 2007-01-24 | Novartis Vaccines and Diagnostics, Inc. | Hepatitis c viral antigen immunoassay detection systems |
| DK1350105T3 (en) | 2000-06-15 | 2007-11-12 | Novartis Vaccines & Diagnostic | Immunoassays for Enti-HCV Antibodies |
| EP1829891B1 (en) | 2000-06-15 | 2012-12-26 | Novartis Vaccines and Diagnostics, Inc. | Immunoassays for Anti-HCV Antibodies |
| AR045702A1 (en) | 2001-10-03 | 2005-11-09 | Chiron Corp | COMPOSITIONS OF ASSISTANTS. |
| JP4585314B2 (en) | 2002-09-09 | 2010-11-24 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | HCV assay |
| WO2004071414A2 (en) * | 2003-02-05 | 2004-08-26 | Genzyme Corporation | Therapeutic anti-hcv (al9) compounds |
| US7731967B2 (en) | 2003-04-30 | 2010-06-08 | Novartis Vaccines And Diagnostics, Inc. | Compositions for inducing immune responses |
| JP4836281B2 (en) * | 2004-08-27 | 2011-12-14 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス インコーポレイテッド | HCV nonstructural protein variants and uses thereof |
| US8216590B2 (en) | 2006-08-25 | 2012-07-10 | Novartis Ag | HCV fusion polypeptides |
| EP3067048B1 (en) | 2007-12-07 | 2018-02-14 | GlaxoSmithKline Biologicals SA | Compositions for inducing immune responses |
| FR2984328B1 (en) | 2011-12-20 | 2016-12-30 | Bio-Rad Innovations | METHOD FOR DETECTING HEPATITIS C VIRUS INFECTION |
| EP3564384A1 (en) | 2013-03-14 | 2019-11-06 | Abbott Laboratories | Hcv core lipid binding domain monoclonal antibodies |
| EP2970947A4 (en) | 2013-03-14 | 2016-10-12 | Abbott Lab | Hcv ns3 recombinant antigens and mutants thereof for improved antibody detection |
| US9194873B2 (en) | 2013-03-14 | 2015-11-24 | Abbott Laboratories | HCV antigen-antibody combination assay and methods and compositions for use therein |
| US10267803B2 (en) | 2015-03-27 | 2019-04-23 | Ortho-Clinical Diagnostics, Inc. | HCV NS4A/modified NS3 polypeptides and uses thereof |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4855224A (en) * | 1984-03-09 | 1989-08-08 | Genentech, Inc. | Molecularly cloned diagnostic product and method of use |
| ES2012739T5 (en) | 1987-11-18 | 2001-12-01 | Chiron Corp | DIAGNOSTICS FOR NANBV. |
| HU225068B1 (en) | 1989-03-17 | 2006-05-29 | Chiron Corp | Process for producing diagnostics and vaccine of nanbh |
| US5372928A (en) * | 1989-09-15 | 1994-12-13 | Chiron Corporation | Hepatitis C virus isolates |
| DE4040339C2 (en) * | 1989-12-18 | 1999-07-08 | Wellcome Found | Viral agent |
| ZA912040B (en) * | 1990-03-30 | 1991-12-24 | Akzo Nv | Peptides immunochemically reactive with antibodies directed against hepatitis non-a,non-b virus |
| PL172133B1 (en) * | 1990-04-04 | 1997-08-29 | Chiron Corp | A method of creating a combination of hepatitis C (HCV) antigens and a method of detecting anti-hepatitis C (HCV) antibodies EN EN EN EN EN EN |
| US5443965A (en) * | 1990-04-06 | 1995-08-22 | Genelabs Incorporated | Hepatitis C virus epitopes |
| FI913068L (en) * | 1990-06-25 | 1991-12-26 | Univ Osaka Res Found | NON-A, NON-B HEPATITIS VIRUS PARTICULARS. |
| KR0181517B1 (en) * | 1990-07-09 | 1999-04-01 | 나까하라 노부유끼 | Non-A Hepatitis-Specific Antigens and Their Uses in the Diagnosis of Hepatitis |
| CZ289006B6 (en) * | 1990-11-08 | 2001-10-17 | Chiron Corporation | Hepatitis C virus asialoglycoprotein, pharmaceutical composition in which the asialoglycoprotein is comprised and use thereof |
| IT1249684B (en) * | 1991-07-19 | 1995-03-09 | Sorin Biomedica Spa | HEPATITIS VIRUS PROTEIN ENV EPITOPES |
| US5587285A (en) * | 1992-01-31 | 1996-12-24 | University Of Texas System | Generation serological assay for monitoring HIV exposure |
| EP0627000B1 (en) * | 1992-01-31 | 2003-10-29 | Abbott Laboratories | Mammalian expression systems for hcv proteins |
-
1993
- 1993-02-07 UA UA95028108A patent/UA39944C2/en unknown
- 1993-07-02 DE DE69331845T patent/DE69331845T3/en not_active Expired - Lifetime
- 1993-07-02 ES ES93916942T patent/ES2171414T5/en not_active Expired - Lifetime
- 1993-07-02 CZ CZ19956A patent/CZ291951B6/en not_active IP Right Cessation
- 1993-07-02 PT PT93916942T patent/PT649537E/en unknown
- 1993-07-02 JP JP50344094A patent/JP3490085B2/en not_active Expired - Lifetime
- 1993-07-02 PL PL93307178A patent/PL174686B1/en unknown
- 1993-07-02 EP EP93916942A patent/EP0649537B2/en not_active Expired - Lifetime
- 1993-07-02 CA CA002139645A patent/CA2139645C/en not_active Expired - Lifetime
- 1993-07-02 WO PCT/US1993/006309 patent/WO1994001778A1/en active IP Right Grant
- 1993-07-02 SK SK4-95A patent/SK284556B6/en not_active IP Right Cessation
- 1993-07-02 RU RU94046284A patent/RU2126158C1/en active
- 1993-07-02 HU HU9500008A patent/HUT70473A/en not_active Application Discontinuation
- 1993-07-02 AU AU46629/93A patent/AU685059B2/en not_active Expired
- 1993-07-02 DK DK93916942T patent/DK0649537T4/en active
- 1993-07-02 AT AT93916942T patent/ATE216779T1/en active
-
1995
- 1995-01-02 FI FI950002A patent/FI110546B/en not_active IP Right Cessation
- 1995-01-02 NO NO19950006A patent/NO321185B1/en not_active IP Right Cessation
-
2001
- 2001-08-02 US US09/920,879 patent/US20020150883A1/en not_active Abandoned
-
2003
- 2003-04-14 JP JP2003109573A patent/JP2003329687A/en not_active Withdrawn
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8363 | Opposition against the patent | ||
| 8366 | Restricted maintained after opposition proceedings | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: NOVARTIS VACCINES AND DIAGNOSTICS,INC.(N.D.GES, US |