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SK287464B6 - Arylované amidy furán- a tiofénkarboxylových kyselín, ich použitie a farmaceutické prostriedky, ktoré ich obsahujú - Google Patents

Arylované amidy furán- a tiofénkarboxylových kyselín, ich použitie a farmaceutické prostriedky, ktoré ich obsahujú Download PDF

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Publication number
SK287464B6
SK287464B6 SK725-2003A SK7252003A SK287464B6 SK 287464 B6 SK287464 B6 SK 287464B6 SK 7252003 A SK7252003 A SK 7252003A SK 287464 B6 SK287464 B6 SK 287464B6
Authority
SK
Slovakia
Prior art keywords
carbon atoms
groups
group
atoms
alkyl
Prior art date
Application number
SK725-2003A
Other languages
English (en)
Slovak (sk)
Other versions
SK7252003A3 (en
Inventor
Stefan Peukert
Joachim Brendel
Horst Hemmerle
Heinz-Werner Kleemann
Original Assignee
Sanofi-Aventis Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis Deutschland Gmbh filed Critical Sanofi-Aventis Deutschland Gmbh
Publication of SK7252003A3 publication Critical patent/SK7252003A3/sk
Publication of SK287464B6 publication Critical patent/SK287464B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SK725-2003A 2000-12-12 2001-11-29 Arylované amidy furán- a tiofénkarboxylových kyselín, ich použitie a farmaceutické prostriedky, ktoré ich obsahujú SK287464B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10061876A DE10061876A1 (de) 2000-12-12 2000-12-12 Arylierte Furan- und Thiophencarbonsäureamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
PCT/EP2001/013958 WO2002048131A1 (de) 2000-12-12 2001-11-29 Arylierte furan- und thiophencarbonsäureamide mit kalium kanal blockierender wirkung

Publications (2)

Publication Number Publication Date
SK7252003A3 SK7252003A3 (en) 2003-12-02
SK287464B6 true SK287464B6 (sk) 2010-10-07

Family

ID=7666837

Family Applications (1)

Application Number Title Priority Date Filing Date
SK725-2003A SK287464B6 (sk) 2000-12-12 2001-11-29 Arylované amidy furán- a tiofénkarboxylových kyselín, ich použitie a farmaceutické prostriedky, ktoré ich obsahujú

Country Status (30)

Country Link
US (1) US6982279B2 (xx)
EP (1) EP1349846B1 (xx)
JP (1) JP4252798B2 (xx)
KR (1) KR20030061846A (xx)
CN (1) CN1225463C (xx)
AR (1) AR032781A1 (xx)
AT (1) ATE288906T1 (xx)
AU (2) AU2002235743B2 (xx)
BR (1) BR0116084A (xx)
CA (1) CA2431095A1 (xx)
CZ (1) CZ20031633A3 (xx)
DE (2) DE10061876A1 (xx)
DK (1) DK1349846T3 (xx)
EE (1) EE05306B1 (xx)
ES (1) ES2236335T3 (xx)
HK (1) HK1061850A1 (xx)
HR (1) HRP20030469A2 (xx)
HU (1) HUP0303665A3 (xx)
IL (2) IL156314A0 (xx)
MX (1) MXPA03004770A (xx)
NO (1) NO329163B1 (xx)
NZ (1) NZ526383A (xx)
PL (1) PL362410A1 (xx)
PT (1) PT1349846E (xx)
RS (1) RS50336B (xx)
RU (1) RU2275366C2 (xx)
SK (1) SK287464B6 (xx)
TW (1) TWI288134B (xx)
WO (1) WO2002048131A1 (xx)
ZA (1) ZA200304091B (xx)

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SI1401825T1 (sl) * 2001-06-11 2010-01-29 Virochem Pharma Inc Tiofenski derivati kot protivirusna sredstva za flavirusno infekcijo
US8329924B2 (en) * 2001-06-11 2012-12-11 Vertex Pharmaceuticals (Canada) Incorporated Compounds and methods for the treatment or prevention of Flavivirus infections
PT1569929E (pt) 2002-12-10 2010-06-18 Virochem Pharma Inc Compostos e métodos para o tratamento ou prevenção de infecções por flavivírus
GB0315950D0 (en) 2003-06-11 2003-08-13 Xention Discovery Ltd Compounds
EP1493739A1 (fr) * 2003-07-03 2005-01-05 Warner-Lambert Company LLC Dérivés thiophényliques d'aminoacides, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
GB0324269D0 (en) * 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
GB0412986D0 (en) 2004-06-10 2004-07-14 Xention Discovery Ltd Compounds
US7569589B2 (en) 2004-07-29 2009-08-04 Merck & Co., Inc. Potassium channel inhibitors
US7576212B2 (en) 2004-12-09 2009-08-18 Xention Limited Thieno[2,3-B] pyridines as potassium channel inhibitors
AU2006246227B2 (en) * 2005-05-13 2011-04-28 Virochem Pharma Inc. Compounds and methods for the treatment or prevention of flavivirus infections
JP4943429B2 (ja) * 2005-07-22 2012-05-30 メルク・シャープ・エンド・ドーム・コーポレイション カリウムチャネル阻害剤
GB0525164D0 (en) 2005-12-09 2006-01-18 Xention Discovery Ltd Compounds
BRPI0710946A2 (pt) * 2006-04-27 2012-03-06 Sanofi-Aventis Deutschland Gmbh inibidores dos canais de Íon task-1 e task-3
KR20090086081A (ko) 2006-11-15 2009-08-10 바이로켐 파마 인코포레이티드 플라비바이러스 감염의 치료 또는 예방용 티오펜 유사체
EP2200607A4 (en) * 2007-09-10 2012-02-22 Calcimedica Inc COMPOUNDS MODULATING INTRACELLULAR CALCIUM
ITMI20071971A1 (it) * 2007-10-10 2009-04-11 Altergon Sa Composizione farmaceutica per la somministrazione sublinguale di progesterone, e metodo per la sua preparazione
WO2009076454A2 (en) 2007-12-12 2009-06-18 Calcimedica, Inc. Compounds that modulate intracellular calcium
BRPI0917719A2 (pt) 2008-08-27 2019-11-19 Calcimedica Inc compostos que modulam cálcio intracelular
GB0815781D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815782D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815784D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
US8524763B2 (en) 2008-09-22 2013-09-03 Calcimedica, Inc. Inhibitors of store operated calcium release
US8143269B2 (en) 2008-10-03 2012-03-27 Calcimedica, Inc. Inhibitors of store operated calcium release
KR101420484B1 (ko) * 2009-01-30 2014-07-28 글락소스미스클라인 엘엘씨 결정질 ｎ-｛(1ｓ)-2-아미노-1-［(3-플루오로페닐)메틸］에틸｝-5-클로로-4-(4-클로로-1-메틸-1ｈ-피라졸-5-일)-2-티오펜카르복스아미드 히드로클로라이드
WO2011034962A2 (en) 2009-09-16 2011-03-24 Calcimedica Inc. Compounds that modulate intracellular calcium
CN104860907A (zh) 2010-06-07 2015-08-26 诺沃梅迪科斯有限公司 呋喃基化合物及其用途
WO2012027710A2 (en) 2010-08-27 2012-03-01 Calcimedica Inc. Compounds that modulate intracellular calcium
GB201105659D0 (en) 2011-04-01 2011-05-18 Xention Ltd Compounds
NO3175985T3 (xx) 2011-07-01 2018-04-28
CA2862670A1 (en) 2012-01-27 2013-08-01 Gilead Sciences, Inc. Combination therapies using late sodium ion channel blockers and potassium ion channel blockers
US9512116B2 (en) 2012-10-12 2016-12-06 Calcimedica, Inc. Compounds that modulate intracellular calcium
CN103012381B (zh) * 2013-01-10 2015-01-07 山东大学 苯基呋喃类化合物、其制备方法及在制备抗心律失常药物中的应用
KR101721490B1 (ko) * 2014-07-30 2017-03-30 한국생명공학연구원 페닐 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 세포증식성 질병의 예방 또는 치료용 약학적 조성물
EP3366683A1 (en) * 2017-02-28 2018-08-29 Acousia Therapeutics GmbH Cyclic amides, acteamides and ureas useful as potassium channel openers

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DK41193D0 (da) * 1993-04-07 1993-04-07 Neurosearch As Ionkanalaabnere
IL109570A0 (en) * 1993-05-17 1994-08-26 Fujisawa Pharmaceutical Co Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof
DE4412334A1 (de) * 1994-04-11 1995-10-19 Hoechst Ag Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US5670504A (en) 1995-02-23 1997-09-23 Merck & Co. Inc. 2,6-diaryl pyridazinones with immunosuppressant activity
US6083986A (en) 1996-07-26 2000-07-04 Icagen, Inc. Potassium channel inhibitors
US5935945A (en) 1996-10-31 1999-08-10 Merck & Co., Inc. Methods of treating or preventing cardiac arrhythmia
US5969017A (en) 1996-10-31 1999-10-19 Merck & Co., Inc. Methods of treating or preventing cardiac arrhythmia
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ES2215337T3 (es) * 1997-12-19 2004-10-01 Schering Aktiengesellschaft Derivados de orto-antranilamida como anticoagulantes.
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Also Published As

Publication number Publication date
IL156314A0 (en) 2004-01-04
CN1225463C (zh) 2005-11-02
TWI288134B (en) 2007-10-11
HUP0303665A2 (hu) 2004-03-01
AU2002235743B2 (en) 2006-07-20
PT1349846E (pt) 2005-05-31
KR20030061846A (ko) 2003-07-22
JP2004526680A (ja) 2004-09-02
CN1479734A (zh) 2004-03-03
EP1349846A1 (de) 2003-10-08
AU3574302A (en) 2002-06-24
ZA200304091B (en) 2004-04-23
CZ20031633A3 (cs) 2003-08-13
RS50336B (sr) 2009-11-10
PL362410A1 (en) 2004-11-02
NO20032535D0 (no) 2003-06-04
RU2275366C2 (ru) 2006-04-27
HUP0303665A3 (en) 2005-02-28
YU42503A (sh) 2006-05-25
HK1061850A1 (en) 2004-10-08
DE50105337D1 (de) 2005-03-17
JP4252798B2 (ja) 2009-04-08
SK7252003A3 (en) 2003-12-02
DE10061876A1 (de) 2002-06-20
IL156314A (en) 2008-12-29
MXPA03004770A (es) 2003-09-10
ATE288906T1 (de) 2005-02-15
AR032781A1 (es) 2003-11-26
BR0116084A (pt) 2003-10-14
CA2431095A1 (en) 2002-06-20
NZ526383A (en) 2004-11-26
HRP20030469A2 (en) 2005-04-30
US20040068120A1 (en) 2004-04-08
ES2236335T3 (es) 2005-07-16
WO2002048131A1 (de) 2002-06-20
DK1349846T3 (da) 2005-05-30
NO20032535L (no) 2003-07-29
EP1349846B1 (de) 2005-02-09
EE200300240A (et) 2003-08-15
US6982279B2 (en) 2006-01-03
EE05306B1 (et) 2010-06-15
NO329163B1 (no) 2010-08-30

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Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20111129