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BR0116084A - Amidas de ácido furanocarboxìlico e tiofenocarboxìlico ariladas com efeito bloqueador de canal de potássio - Google Patents

Amidas de ácido furanocarboxìlico e tiofenocarboxìlico ariladas com efeito bloqueador de canal de potássio

Info

Publication number
BR0116084A
BR0116084A BR0116084-2A BR0116084A BR0116084A BR 0116084 A BR0116084 A BR 0116084A BR 0116084 A BR0116084 A BR 0116084A BR 0116084 A BR0116084 A BR 0116084A
Authority
BR
Brazil
Prior art keywords
acid amides
atrial
arylated
potassium channel
furanecarboxylic
Prior art date
Application number
BR0116084-2A
Other languages
English (en)
Inventor
Stefan Peukert
Joachim Brendel
Horst Hemmerle
Heinz-Werner Kleemann
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of BR0116084A publication Critical patent/BR0116084A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"AMIDAS DE áCIDO FURANOCARBOXìLICO E TIOFENOCARBOXìLICO ARILADAS COM EFEITO BLOQUEADOR DE CANAL DE POTáSSIO". Amidas de ácido furanocarboxílico e tiofenocarboxílico ariladas, processo para sua preparação, seu emprego como medicamento, assim como preparados farmacêuticos contendo-as. Compostos de fórmula (Ia) e (Ib) nas quais X, R(1), R(2), R(3), R(4), R(5), R(6), R(7), e R(30) e R(31) têm os significados indicados nas reivindicações, são muito particularmente apropriados como substâncias ativas anti-arrítmicas novas, particularmente para tratamento e profilaxia de arritmias do átrio, por exemplo, vibração atrial (fibrilação atrial, AF) ou instabilidade atrial (instabilidade do átrio).
BR0116084-2A 2000-12-12 2001-11-29 Amidas de ácido furanocarboxìlico e tiofenocarboxìlico ariladas com efeito bloqueador de canal de potássio BR0116084A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10061876A DE10061876A1 (de) 2000-12-12 2000-12-12 Arylierte Furan- und Thiophencarbonsäureamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
PCT/EP2001/013958 WO2002048131A1 (de) 2000-12-12 2001-11-29 Arylierte furan- und thiophencarbonsäureamide mit kalium kanal blockierender wirkung

Publications (1)

Publication Number Publication Date
BR0116084A true BR0116084A (pt) 2003-10-14

Family

ID=7666837

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0116084-2A BR0116084A (pt) 2000-12-12 2001-11-29 Amidas de ácido furanocarboxìlico e tiofenocarboxìlico ariladas com efeito bloqueador de canal de potássio

Country Status (30)

Country Link
US (1) US6982279B2 (pt)
EP (1) EP1349846B1 (pt)
JP (1) JP4252798B2 (pt)
KR (1) KR20030061846A (pt)
CN (1) CN1225463C (pt)
AR (1) AR032781A1 (pt)
AT (1) ATE288906T1 (pt)
AU (2) AU2002235743B2 (pt)
BR (1) BR0116084A (pt)
CA (1) CA2431095A1 (pt)
CZ (1) CZ20031633A3 (pt)
DE (2) DE10061876A1 (pt)
DK (1) DK1349846T3 (pt)
EE (1) EE05306B1 (pt)
ES (1) ES2236335T3 (pt)
HK (1) HK1061850A1 (pt)
HR (1) HRP20030469A2 (pt)
HU (1) HUP0303665A3 (pt)
IL (2) IL156314A0 (pt)
MX (1) MXPA03004770A (pt)
NO (1) NO329163B1 (pt)
NZ (1) NZ526383A (pt)
PL (1) PL362410A1 (pt)
PT (1) PT1349846E (pt)
RS (1) RS50336B (pt)
RU (1) RU2275366C2 (pt)
SK (1) SK287464B6 (pt)
TW (1) TWI288134B (pt)
WO (1) WO2002048131A1 (pt)
ZA (1) ZA200304091B (pt)

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PT1569929E (pt) 2002-12-10 2010-06-18 Virochem Pharma Inc Compostos e métodos para o tratamento ou prevenção de infecções por flavivírus
GB0315950D0 (en) 2003-06-11 2003-08-13 Xention Discovery Ltd Compounds
EP1493739A1 (fr) * 2003-07-03 2005-01-05 Warner-Lambert Company LLC Dérivés thiophényliques d'aminoacides, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
GB0324269D0 (en) * 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
GB0412986D0 (en) 2004-06-10 2004-07-14 Xention Discovery Ltd Compounds
US7569589B2 (en) 2004-07-29 2009-08-04 Merck & Co., Inc. Potassium channel inhibitors
US7576212B2 (en) 2004-12-09 2009-08-18 Xention Limited Thieno[2,3-B] pyridines as potassium channel inhibitors
AU2006246227B2 (en) * 2005-05-13 2011-04-28 Virochem Pharma Inc. Compounds and methods for the treatment or prevention of flavivirus infections
JP4943429B2 (ja) * 2005-07-22 2012-05-30 メルク・シャープ・エンド・ドーム・コーポレイション カリウムチャネル阻害剤
GB0525164D0 (en) 2005-12-09 2006-01-18 Xention Discovery Ltd Compounds
BRPI0710946A2 (pt) * 2006-04-27 2012-03-06 Sanofi-Aventis Deutschland Gmbh inibidores dos canais de Íon task-1 e task-3
KR20090086081A (ko) 2006-11-15 2009-08-10 바이로켐 파마 인코포레이티드 플라비바이러스 감염의 치료 또는 예방용 티오펜 유사체
EP2200607A4 (en) * 2007-09-10 2012-02-22 Calcimedica Inc COMPOUNDS MODULATING INTRACELLULAR CALCIUM
ITMI20071971A1 (it) * 2007-10-10 2009-04-11 Altergon Sa Composizione farmaceutica per la somministrazione sublinguale di progesterone, e metodo per la sua preparazione
WO2009076454A2 (en) 2007-12-12 2009-06-18 Calcimedica, Inc. Compounds that modulate intracellular calcium
BRPI0917719A2 (pt) 2008-08-27 2019-11-19 Calcimedica Inc compostos que modulam cálcio intracelular
GB0815781D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815782D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815784D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
US8524763B2 (en) 2008-09-22 2013-09-03 Calcimedica, Inc. Inhibitors of store operated calcium release
US8143269B2 (en) 2008-10-03 2012-03-27 Calcimedica, Inc. Inhibitors of store operated calcium release
KR101420484B1 (ko) * 2009-01-30 2014-07-28 글락소스미스클라인 엘엘씨 결정질 ｎ-｛(1ｓ)-2-아미노-1-［(3-플루오로페닐)메틸］에틸｝-5-클로로-4-(4-클로로-1-메틸-1ｈ-피라졸-5-일)-2-티오펜카르복스아미드 히드로클로라이드
WO2011034962A2 (en) 2009-09-16 2011-03-24 Calcimedica Inc. Compounds that modulate intracellular calcium
CN104860907A (zh) 2010-06-07 2015-08-26 诺沃梅迪科斯有限公司 呋喃基化合物及其用途
WO2012027710A2 (en) 2010-08-27 2012-03-01 Calcimedica Inc. Compounds that modulate intracellular calcium
GB201105659D0 (en) 2011-04-01 2011-05-18 Xention Ltd Compounds
NO3175985T3 (pt) 2011-07-01 2018-04-28
CA2862670A1 (en) 2012-01-27 2013-08-01 Gilead Sciences, Inc. Combination therapies using late sodium ion channel blockers and potassium ion channel blockers
US9512116B2 (en) 2012-10-12 2016-12-06 Calcimedica, Inc. Compounds that modulate intracellular calcium
CN103012381B (zh) * 2013-01-10 2015-01-07 山东大学 苯基呋喃类化合物、其制备方法及在制备抗心律失常药物中的应用
KR101721490B1 (ko) * 2014-07-30 2017-03-30 한국생명공학연구원 페닐 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 세포증식성 질병의 예방 또는 치료용 약학적 조성물
EP3366683A1 (en) * 2017-02-28 2018-08-29 Acousia Therapeutics GmbH Cyclic amides, acteamides and ureas useful as potassium channel openers

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Also Published As

Publication number Publication date
IL156314A0 (en) 2004-01-04
CN1225463C (zh) 2005-11-02
TWI288134B (en) 2007-10-11
HUP0303665A2 (hu) 2004-03-01
AU2002235743B2 (en) 2006-07-20
PT1349846E (pt) 2005-05-31
KR20030061846A (ko) 2003-07-22
JP2004526680A (ja) 2004-09-02
CN1479734A (zh) 2004-03-03
EP1349846A1 (de) 2003-10-08
AU3574302A (en) 2002-06-24
ZA200304091B (en) 2004-04-23
CZ20031633A3 (cs) 2003-08-13
RS50336B (sr) 2009-11-10
PL362410A1 (en) 2004-11-02
NO20032535D0 (no) 2003-06-04
RU2275366C2 (ru) 2006-04-27
HUP0303665A3 (en) 2005-02-28
YU42503A (sh) 2006-05-25
HK1061850A1 (en) 2004-10-08
DE50105337D1 (de) 2005-03-17
JP4252798B2 (ja) 2009-04-08
SK7252003A3 (en) 2003-12-02
DE10061876A1 (de) 2002-06-20
IL156314A (en) 2008-12-29
MXPA03004770A (es) 2003-09-10
ATE288906T1 (de) 2005-02-15
AR032781A1 (es) 2003-11-26
SK287464B6 (sk) 2010-10-07
CA2431095A1 (en) 2002-06-20
NZ526383A (en) 2004-11-26
HRP20030469A2 (en) 2005-04-30
US20040068120A1 (en) 2004-04-08
ES2236335T3 (es) 2005-07-16
WO2002048131A1 (de) 2002-06-20
DK1349846T3 (da) 2005-05-30
NO20032535L (no) 2003-07-29
EP1349846B1 (de) 2005-02-09
EE200300240A (et) 2003-08-15
US6982279B2 (en) 2006-01-03
EE05306B1 (et) 2010-06-15
NO329163B1 (no) 2010-08-30

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH (DE)

Free format text: ALTERADO DE: AVENTIS PHARMA DEUTSCHLAND GMBH

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.