[go: up one dir, main page]

SK286247B6 - Benzamidové deriváty, spôsob ich prípravy, farmaceutické prostriedky, ktoré ich obsahujú a ich použitie pri príprave liečiva na liečbu chorobných stavov sprostredkovaných cytokínmi - Google Patents

Benzamidové deriváty, spôsob ich prípravy, farmaceutické prostriedky, ktoré ich obsahujú a ich použitie pri príprave liečiva na liečbu chorobných stavov sprostredkovaných cytokínmi Download PDF

Info

Publication number
SK286247B6
SK286247B6 SK1717-2000A SK17172000A SK286247B6 SK 286247 B6 SK286247 B6 SK 286247B6 SK 17172000 A SK17172000 A SK 17172000A SK 286247 B6 SK286247 B6 SK 286247B6
Authority
SK
Slovakia
Prior art keywords
formula
group
alkyl
phenyl
chloro
Prior art date
Application number
SK1717-2000A
Other languages
English (en)
Slovak (sk)
Other versions
SK17172000A3 (sk
Inventor
Dearg Sutherland Brown
George Robert Brown
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9810356.7A external-priority patent/GB9810356D0/en
Priority claimed from GBGB9905970.1A external-priority patent/GB9905970D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of SK17172000A3 publication Critical patent/SK17172000A3/sk
Publication of SK286247B6 publication Critical patent/SK286247B6/sk

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/56Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/84Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/40Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/49Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/57Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SK1717-2000A 1998-05-15 1999-05-11 Benzamidové deriváty, spôsob ich prípravy, farmaceutické prostriedky, ktoré ich obsahujú a ich použitie pri príprave liečiva na liečbu chorobných stavov sprostredkovaných cytokínmi SK286247B6 (sk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9810356.7A GB9810356D0 (en) 1998-05-15 1998-05-15 Amide derivatives
GBGB9905970.1A GB9905970D0 (en) 1999-03-17 1999-03-17 Amide derivatives
PCT/GB1999/001491 WO1999059960A1 (en) 1998-05-15 1999-05-11 Benzamide derivatives for the treatment of diseases mediated by cytokines

Publications (2)

Publication Number Publication Date
SK17172000A3 SK17172000A3 (sk) 2001-04-09
SK286247B6 true SK286247B6 (sk) 2008-06-06

Family

ID=26313677

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1717-2000A SK286247B6 (sk) 1998-05-15 1999-05-11 Benzamidové deriváty, spôsob ich prípravy, farmaceutické prostriedky, ktoré ich obsahujú a ich použitie pri príprave liečiva na liečbu chorobných stavov sprostredkovaných cytokínmi

Country Status (23)

Country Link
US (1) US6465455B1 (hu)
EP (1) EP1077930B1 (hu)
JP (1) JP2003505337A (hu)
KR (1) KR100628284B1 (hu)
CN (1) CN1188389C (hu)
AT (1) ATE282023T1 (hu)
AU (1) AU748397B2 (hu)
BR (1) BR9910467A (hu)
CA (1) CA2328699A1 (hu)
DE (1) DE69921804T2 (hu)
ES (1) ES2230853T3 (hu)
HK (1) HK1033753A1 (hu)
HU (1) HUP0102367A3 (hu)
ID (1) ID27285A (hu)
IL (1) IL139710A (hu)
NO (1) NO20005766L (hu)
NZ (1) NZ507143A (hu)
PL (1) PL197181B1 (hu)
PT (1) PT1077930E (hu)
RU (1) RU2205823C2 (hu)
SK (1) SK286247B6 (hu)
TR (1) TR200003355T2 (hu)
WO (1) WO1999059960A1 (hu)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9816837D0 (en) 1998-08-04 1998-09-30 Zeneca Ltd Amide derivatives
US7772432B2 (en) 1991-09-19 2010-08-10 Astrazeneca Ab Amidobenzamide derivatives which are useful as cytokine inhibitors
ES2188005T3 (es) 1997-09-23 2003-06-16 Astrazeneca Ab Derivados de amidas para el tratamiento de enfermedades mediadas por citoquinas.
JP2003505337A (ja) 1998-05-15 2003-02-12 アストラゼネカ アクチボラグ サイトカインにより仲介される疾病を処置するためのベンズアミド誘導体
HUP0102295A3 (en) 1998-05-15 2002-11-28 Astrazeneca Ab Benzamide derivatives for the treatment of diseases mediated by cytokines
US6858617B2 (en) 1998-05-26 2005-02-22 Smithkline Beecham Corporation Substituted imidazole compounds
MXPA01000895A (es) 1998-08-04 2002-08-20 Astrazeneca Ab Derivados de amida utiles como inhibidores de la produccion de citocinas.
ES2221426T3 (es) 1998-08-20 2004-12-16 Smithkline Beecham Corporation Nuevos compuestos de triazol sustituidos.
TR200100840T2 (tr) 1998-09-25 2001-10-22 Astrazeneca Ab Benzamid türevleri ve bunların sitokin inhibe edicileri olarak kullanımı
JP2002528506A (ja) 1998-11-04 2002-09-03 スミスクライン・ビーチャム・コーポレイション ピリジン−4−イルまたはピリミジン−4−イル置換ピラジン
DK1163237T3 (da) 1999-03-17 2004-08-02 Astrazeneca Ab Amidderivater
DE60022328T2 (de) * 1999-03-17 2006-06-01 Astrazeneca Ab Amid-derivate
GB9906566D0 (en) 1999-03-23 1999-05-19 Zeneca Ltd Chemical compounds
GB9924092D0 (en) 1999-10-13 1999-12-15 Zeneca Ltd Pyrimidine derivatives
EP1233950B1 (en) 1999-11-23 2005-10-05 Smithkline Beecham Corporation 3,4-DIHYDRO-(1H)QUINAZOLIN-2-ONE COMPOUNDS AS CSBP/P39 kINASE INHIBITORS
ES2241675T3 (es) 1999-11-23 2005-11-01 Smithkline Beecham Corporation Compuestos de 3,4-dihidro-(1h)quinazolin-2-ona como inhibidores de cspb/p38 quinasa.
JP2003514899A (ja) 1999-11-23 2003-04-22 スミスクライン・ビーチャム・コーポレイション CSBP/p38キナーゼ阻害剤としての3,4‐ジヒドロ−(1H)−キナゾリン−2−オン化合物
US6943161B2 (en) 1999-12-28 2005-09-13 Pharmacopela Drug Discovery, Inc. Pyrimidine and triazine kinase inhibitors
US7235551B2 (en) 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
KR20090090406A (ko) * 2000-12-18 2009-08-25 가부시키가이샤 이야쿠 분지 셋케이 겐쿠쇼 염증성 사이토카인 생산 유리 억제제
EP1389203B8 (en) 2001-02-27 2010-03-10 The Governement of the United States of America, represented by The Secretary Department of Health and Human services Analogs of thalidomide as angiogenesis inhibitors
AU2003242098B2 (en) * 2002-06-10 2008-11-20 Institute Of Medicinal Molecular Design, Inc Inhibitors against activation of NFkappaB
AU2003281198A1 (en) * 2002-07-04 2004-01-23 Mitsui Chemicals, Inc. m-PHENYLENEDIAMINE DERIVATIVE
JP2005538066A (ja) 2002-07-09 2005-12-15 ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト 新規な抗コリン作用薬及びp38キナーゼ阻害剤を用いた新規な医薬組成物
CN1867331B (zh) 2003-09-17 2010-05-26 美国政府健康及人类服务部 作为TNF-α调节剂的沙利度胺类似物
US8952895B2 (en) 2011-06-03 2015-02-10 Apple Inc. Motion-based device operations
GB0324790D0 (en) 2003-10-24 2003-11-26 Astrazeneca Ab Amide derivatives
US20060035893A1 (en) 2004-08-07 2006-02-16 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
PE20060777A1 (es) 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
CA2627497C (en) 2005-10-28 2014-10-14 Takeda Pharmaceutical Company Limited Heterocyclic amide compound and use thereof
JP5225857B2 (ja) * 2005-11-14 2013-07-03 ジェネンテック,インコーポレイティド ヘッジホッグシグナル伝達のビスアミド阻害剤
WO2007120669A1 (en) 2006-04-13 2007-10-25 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Tetrahalogenated compounds useful as inhibitors of angiogenesis
US7671058B2 (en) * 2006-06-21 2010-03-02 Institute Of Medicinal Molecular Design, Inc. N-(3,4-disubstituted phenyl) salicylamide derivatives
WO2008089034A2 (en) * 2007-01-11 2008-07-24 Kemia, Inc. Cytokine inhibitors
EP1992344A1 (en) 2007-05-18 2008-11-19 Institut Curie P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation
US8927725B2 (en) 2011-12-02 2015-01-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Thio compounds
CN104326937B (zh) * 2014-09-03 2016-08-24 天津市肿瘤研究所 抗肿瘤化合物及其医药用途
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Hdac抑制劑與pd-l1抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1903899A (en) 1933-04-18 Cabboxylic acid abylides oe the benzene sebies and process oe making
US1909960A (en) 1929-08-06 1933-05-23 Du Pont Intermediate for azo dyes
DE2812252A1 (de) 1978-03-21 1979-10-04 Bayer Ag 1,2,4-triazol-blockierte polyisocyanate als vernetzer fuer lackbindemittel
US4524168A (en) 1981-11-18 1985-06-18 Ciba-Geigy Corporation Process for the mass coloration of polymers
US4749729A (en) 1984-06-21 1988-06-07 American Cyanamid Company Epoxy resin compositions curable above 160 F. and below 250 F.
AU2552492A (en) 1991-08-23 1993-03-16 United States of America as represented by The Secretary Department of Health and Human Services, The Raf protein kinase therapeutics
GB9816837D0 (en) 1998-08-04 1998-09-30 Zeneca Ltd Amide derivatives
WO1997005878A1 (en) 1995-08-10 1997-02-20 Merck & Co., Inc. 2,5-substituted aryl pyrroles, compositions containing such compounds and methods of use
WO1997008133A1 (en) * 1995-08-22 1997-03-06 Japan Tobacco Inc. Amide compounds and use of the same
GB9604926D0 (en) 1996-03-08 1996-05-08 Sandoz Ltd Organic compounds
EP0922042A1 (en) * 1996-08-09 1999-06-16 Smithkline Beecham Corporation Novel piperazine containing compounds
GB9623833D0 (en) 1996-11-16 1997-01-08 Zeneca Ltd Chemical compound
ES2188005T3 (es) * 1997-09-23 2003-06-16 Astrazeneca Ab Derivados de amidas para el tratamiento de enfermedades mediadas por citoquinas.
GB9809347D0 (en) 1998-05-05 1998-07-01 Reckitt & Colmann Prod Ltd Compositions
HUP0102295A3 (en) 1998-05-15 2002-11-28 Astrazeneca Ab Benzamide derivatives for the treatment of diseases mediated by cytokines
JP2003505337A (ja) 1998-05-15 2003-02-12 アストラゼネカ アクチボラグ サイトカインにより仲介される疾病を処置するためのベンズアミド誘導体
MXPA01000895A (es) 1998-08-04 2002-08-20 Astrazeneca Ab Derivados de amida utiles como inhibidores de la produccion de citocinas.
TR200100840T2 (tr) 1998-09-25 2001-10-22 Astrazeneca Ab Benzamid türevleri ve bunların sitokin inhibe edicileri olarak kullanımı
ATE232205T1 (de) 1998-10-01 2003-02-15 Astrazeneca Ab Chinolin- und chinazolin derivate und ihre verwendung als inhibitoren von krankheiten, bei denen cytokine beteiligt wird
DK1163237T3 (da) 1999-03-17 2004-08-02 Astrazeneca Ab Amidderivater
DE60022328T2 (de) 1999-03-17 2006-06-01 Astrazeneca Ab Amid-derivate
GB9924092D0 (en) 1999-10-13 1999-12-15 Zeneca Ltd Pyrimidine derivatives

Also Published As

Publication number Publication date
EP1077930A1 (en) 2001-02-28
BR9910467A (pt) 2001-01-09
PL197181B1 (pl) 2008-03-31
AU3839299A (en) 1999-12-06
EP1077930B1 (en) 2004-11-10
HUP0102367A3 (en) 2002-11-28
ID27285A (id) 2001-03-22
IL139710A (en) 2005-07-25
SK17172000A3 (sk) 2001-04-09
DE69921804T2 (de) 2005-10-27
PT1077930E (pt) 2005-03-31
CN1359371A (zh) 2002-07-17
ES2230853T3 (es) 2005-05-01
US6465455B1 (en) 2002-10-15
JP2003505337A (ja) 2003-02-12
DE69921804D1 (de) 2004-12-16
RU2205823C2 (ru) 2003-06-10
KR100628284B1 (ko) 2006-09-27
PL344185A1 (en) 2001-10-08
TR200003355T2 (tr) 2001-03-21
CN1188389C (zh) 2005-02-09
AU748397B2 (en) 2002-06-06
CA2328699A1 (en) 1999-11-25
HUP0102367A2 (hu) 2001-10-28
KR20010043547A (ko) 2001-05-25
NZ507143A (en) 2003-08-29
WO1999059960A1 (en) 1999-11-25
HK1033753A1 (en) 2001-09-21
IL139710A0 (en) 2002-02-10
ATE282023T1 (de) 2004-11-15
NO20005766D0 (no) 2000-11-14
NO20005766L (no) 2001-01-12

Similar Documents

Publication Publication Date Title
US6465455B1 (en) Benzamide derivatives for the treatment of diseases mediated by cytokines
EP1017378B1 (en) Amide derivatives for the treatment of diseases mediated by cytokines
US6593333B1 (en) Substituted anilino-quinazoline (or quinoline) compounds and use thereof
EP1077931B1 (en) Benzamide derivatives for the treatment of diseases mediated by cytokines
EP1102743B1 (en) Amide derivatives which are useful as cytokine inhibitors
PL200804B1 (pl) Pochodne amidowe, sposoby ich wytwarzania, ich kompozycje farmaceutyczne oraz ich zastosowanie
CZ20004209A3 (cs) Benzamidové deriváty pro léčbu nemocí zprostředkovaných cytokiny, způsob jejich přípravy a léčebné prostředky, které je obsahují
MXPA00010355A (en) Benzamide derivatives for the treatment of diseases mediated by cytokines
MXPA00002675A (en) Amide derivatives for the treatment of diseases mediated by cytokines
CZ20004210A3 (cs) Benzamidové deriváty pro léčení nemoci mediovaných cytokiny
MXPA00010432A (en) Benzamide derivatives for the treatment of diseases mediated by cytokines
MXPA01003424A (es) Compuestos quimicos