SK282469B6 - Opiátové peptidy, farmaceutická kompozícia s ich obsahom a ich použitie - Google Patents

Opiátové peptidy, farmaceutická kompozícia s ich obsahom a ich použitie Download PDF

Info

Publication number: SK282469B6
Authority: SK; Slovakia
Prior art keywords: phe; compound; tyr; ala; arg
Prior art date: 1995-08-18

Application number

SK203-98A

Other languages

English (en)

Slovak (sk)

Other versions

SK20398A3 (en

Inventor

Wuyi Wang

Original Assignee

Astra Aktiebolag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-08-18

Filing date

1996-08-14

Publication date

2002-02-05

1995-08-18 Priority claimed from SE9502877A external-priority patent/SE9502877D0/xx

1996-08-14 Application filed by Astra Aktiebolag filed Critical Astra Aktiebolag

1998-12-02 Publication of SK20398A3 publication Critical patent/SK20398A3/sk

2002-02-05 Publication of SK282469B6 publication Critical patent/SK282469B6/sk

Links

108010093625 Opioid Peptides Proteins 0.000 title claims abstract description 8
102000001490 Opioid Peptides Human genes 0.000 title claims abstract description 8
239000003399 opiate peptide Substances 0.000 title claims abstract description 8
239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 7
230000000202 analgesic effect Effects 0.000 claims abstract description 27
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims abstract description 9
238000002360 preparation method Methods 0.000 claims abstract description 8
150000003839 salts Chemical class 0.000 claims abstract description 8
LSNDLIKCFHLFKO-JTQLQIEISA-N (2s)-2-azaniumyl-3-(4-hydroxy-2,6-dimethylphenyl)propanoate Chemical compound CC1=CC(O)=CC(C)=C1C[C@H](N)C(O)=O LSNDLIKCFHLFKO-JTQLQIEISA-N 0.000 claims abstract description 7
ODKSFYDXXFIFQN-SCSAIBSYSA-N D-arginine Chemical compound OC(=O)[C@H](N)CCCNC(N)=N ODKSFYDXXFIFQN-SCSAIBSYSA-N 0.000 claims abstract description 7
QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 claims abstract description 5
239000001257 hydrogen Substances 0.000 claims abstract description 4
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 4
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150000001875 compounds Chemical class 0.000 claims description 59
239000003937 drug carrier Substances 0.000 claims description 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 3
125000000030 D-alanine group Chemical group [H]N([H])[C@](C([H])([H])[H])(C(=O)[*])[H] 0.000 claims description 2
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AKRYBBWYDSDZHG-UHFFFAOYSA-N nitrosobis(2-oxopropyl)amine Chemical compound CC(=O)CN(N=O)CC(C)=O AKRYBBWYDSDZHG-UHFFFAOYSA-N 0.000 description 2
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

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Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

SK203-98A 1995-08-18 1996-08-14 Opiátové peptidy, farmaceutická kompozícia s ich obsahom a ich použitie SK282469B6 (sk)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
SE9502877A SE9502877D0 (sv)	1995-08-18	1995-08-18	Novel opioid peptides
SE9503924A SE9503924D0 (sv)	1995-08-18	1995-11-07	Novel opioid peptides
PCT/SE1996/001011 WO1997007130A1 (en)	1995-08-18	1996-08-14	Novel opioid peptides

Publications (2)

Publication Number	Publication Date
SK20398A3 SK20398A3 (en)	1998-12-02
SK282469B6 true SK282469B6 (sk)	2002-02-05

Family

ID=26662362

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK203-98A SK282469B6 (sk)	1995-08-18	1996-08-14	Opiátové peptidy, farmaceutická kompozícia s ich obsahom a ich použitie

Country Status (27)

Country	Link
US (1)	US6337319B1 (da)
EP (1)	EP0845003B1 (da)
JP (1)	JPH11512086A (da)
KR (1)	KR19990037677A (da)
CN (1)	CN1200127A (da)
AR (1)	AR003475A1 (da)
AT (1)	ATE210148T1 (da)
AU (1)	AU711862B2 (da)
BR (1)	BR9610248A (da)
CA (1)	CA2229797A1 (da)
CZ (1)	CZ287299B6 (da)
DE (1)	DE69617699T2 (da)
DK (1)	DK0845003T3 (da)
EE (1)	EE9800048A (da)
ES (1)	ES2171224T3 (da)
HU (1)	HUP9901209A3 (da)
IL (1)	IL123258A (da)
IS (1)	IS4664A (da)
NO (1)	NO980592L (da)
NZ (1)	NZ315809A (da)
PL (1)	PL325113A1 (da)
RU (1)	RU2165432C2 (da)
SE (1)	SE9503924D0 (da)
SK (1)	SK282469B6 (da)
TR (1)	TR199800258T1 (da)
TW (1)	TW424095B (da)
WO (1)	WO1997007130A1 (da)

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US7842662B2 (en)	2006-11-10	2010-11-30	Cara Therapeutics, Inc.	Synthetic peptide amide dimers
US8906859B2 (en)	2006-11-10	2014-12-09	Cera Therapeutics, Inc.	Uses of kappa opioid synthetic peptide amides
CA2667155C (en)	2006-11-10	2016-05-10	Cara Therapeutics, Inc.	Synthetic peptide amides
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EP2273983B1 (en) *	2008-05-09	2016-07-20	Grünenthal GmbH	Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step
EP2997965B1 (en)	2009-07-22	2019-01-02	Grünenthal GmbH	Tamper-resistant dosage form for oxidation-sensitive opioids
CA2765971C (en)	2009-07-22	2017-08-22	Gruenenthal Gmbh	Hot-melt extruded controlled release dosage form
US9579285B2 (en) *	2010-02-03	2017-02-28	Gruenenthal Gmbh	Preparation of a powdery pharmaceutical composition by means of an extruder
US20160176930A1 (en)	2010-07-09	2016-06-23	The Administrators Of The Tulane Educational Fund	Mu opioid receptor agonist analogs of the endomorphins
PE20131102A1 (es)	2010-09-02	2013-10-12	Gruenenthal Chemie	Forma de dosificacion resistente a manipulacion que comprende una sal inorganica
AR082862A1 (es)	2010-09-02	2013-01-16	Gruenenthal Gmbh	Forma de dosificacion resistente a alteracion que comprende un polimero anionico
EA201400172A1 (ru)	2011-07-29	2014-06-30	Грюненталь Гмбх	Устойчивая к разрушению таблетка, которая обеспечивает немедленное высвобождение лекарственного средства
AR087359A1 (es)	2011-07-29	2014-03-19	Gruenenthal Gmbh	Tableta a prueba de alteracion que proporciona liberacion inmediata del farmaco
EP2819656A1 (en)	2012-02-28	2015-01-07	Grünenthal GmbH	Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
AU2013248351B2 (en)	2012-04-18	2018-04-26	Grunenthal Gmbh	Tamper resistant and dose-dumping resistant pharmaceutical dosage form
US10064945B2 (en)	2012-05-11	2018-09-04	Gruenenthal Gmbh	Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
CN102964279B (zh) *	2012-12-12	2014-05-07	中国药科大学	一类具有外周镇痛作用的κ阿片受体激动剂
AR096438A1 (es)	2013-05-29	2015-12-30	Gruenenthal Gmbh	Forma de dosificación resistente al uso indebido con perfil de liberación bimodal, proceso
AU2014273227B2 (en)	2013-05-29	2019-08-15	Grunenthal Gmbh	Tamper-resistant dosage form containing one or more particles
KR20160031526A (ko)	2013-07-12	2016-03-22	그뤼넨탈 게엠베하	에틸렌-비닐 아세테이트 중합체를 함유하는 템퍼 내성 투여형
BR112016010482B1 (pt)	2013-11-26	2022-11-16	Grünenthal GmbH	Preparação de uma composição farmacêutica em pó por meio de criomoagem
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IS4261A (is)	1994-02-21	1995-08-22	Astra Aktiebolag	Nýir peptíð-ópíóíðar til meðhöndlunar á verkjum og notkun þeirra

1995
- 1995-11-07 SE SE9503924A patent/SE9503924D0/xx unknown
1996
- 1996-08-06 AR ARP960103900A patent/AR003475A1/es active IP Right Grant
- 1996-08-14 JP JP9509209A patent/JPH11512086A/ja active Pending
- 1996-08-14 CZ CZ1998401A patent/CZ287299B6/cs not_active IP Right Cessation
- 1996-08-14 EE EE9800048A patent/EE9800048A/xx unknown
- 1996-08-14 NZ NZ315809A patent/NZ315809A/xx unknown
- 1996-08-14 PL PL96325113A patent/PL325113A1/xx unknown
- 1996-08-14 AU AU67600/96A patent/AU711862B2/en not_active Ceased
- 1996-08-14 WO PCT/SE1996/001011 patent/WO1997007130A1/en not_active Application Discontinuation
- 1996-08-14 RU RU98104253/04A patent/RU2165432C2/ru active
- 1996-08-14 SK SK203-98A patent/SK282469B6/sk unknown
- 1996-08-14 CN CN96197625A patent/CN1200127A/zh active Pending
- 1996-08-14 CA CA002229797A patent/CA2229797A1/en not_active Abandoned
- 1996-08-14 IL IL12325896A patent/IL123258A/xx not_active IP Right Cessation
- 1996-08-14 DE DE69617699T patent/DE69617699T2/de not_active Expired - Fee Related
- 1996-08-14 DK DK96927978T patent/DK0845003T3/da active
- 1996-08-14 AT AT96927978T patent/ATE210148T1/de not_active IP Right Cessation
- 1996-08-14 ES ES96927978T patent/ES2171224T3/es not_active Expired - Lifetime
- 1996-08-14 HU HU9901209A patent/HUP9901209A3/hu unknown
- 1996-08-14 US US08/718,585 patent/US6337319B1/en not_active Expired - Fee Related
- 1996-08-14 TR TR1998/00258T patent/TR199800258T1/xx unknown
- 1996-08-14 KR KR1019980701156A patent/KR19990037677A/ko not_active Application Discontinuation
- 1996-08-14 BR BR9610248A patent/BR9610248A/pt unknown
- 1996-08-14 EP EP96927978A patent/EP0845003B1/en not_active Expired - Lifetime
- 1996-08-15 TW TW085109918A patent/TW424095B/zh not_active IP Right Cessation
1998
- 1998-02-04 IS IS4664A patent/IS4664A/is unknown
- 1998-02-11 NO NO980592A patent/NO980592L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
NZ315809A (en)	1999-05-28
AU6760096A (en)	1997-03-12
TR199800258T1 (xx)	1998-05-21
EP0845003A1 (en)	1998-06-03
BR9610248A (pt)	1999-07-06
US6337319B1 (en)	2002-01-08
HUP9901209A2 (hu)	1999-08-30
CZ40198A3 (cs)	1998-08-12
DK0845003T3 (da)	2002-07-15
ATE210148T1 (de)	2001-12-15
TW424095B (en)	2001-03-01
DE69617699D1 (de)	2002-01-17
CA2229797A1 (en)	1997-02-27
RU2165432C2 (ru)	2001-04-20
SE9503924D0 (sv)	1995-11-07
JPH11512086A (ja)	1999-10-19
IS4664A (is)	1998-02-04
WO1997007130A1 (en)	1997-02-27
AU711862B2 (en)	1999-10-21
EE9800048A (et)	1998-08-17
NO980592D0 (no)	1998-02-11
CN1200127A (zh)	1998-11-25
IL123258A0 (en)	1998-09-24
PL325113A1 (en)	1998-07-06
IL123258A (en)	2003-03-12
AR003475A1 (es)	1998-08-05
DE69617699T2 (de)	2003-08-07
CZ287299B6 (en)	2000-10-11
KR19990037677A (ko)	1999-05-25
ES2171224T3 (es)	2002-09-01
NO980592L (no)	1998-02-11
HUP9901209A3 (en)	2000-12-28
EP0845003B1 (en)	2001-12-05
SK20398A3 (en)	1998-12-02

Publication	Publication Date	Title
SK282469B6 (sk)	2002-02-05	Opiátové peptidy, farmaceutická kompozícia s ich obsahom a ich použitie
EP0746567B1 (en)	2002-05-02	Novel opioid peptides for the treatment of pain and use thereof
US5312899A (en)	1994-05-17	Dermorphin analogs
Hansen Jr et al.	1992	Systemic analgesic activity and. delta.-opioid selectivity in [2, 6-dimethyl-Tyr1, D-Pen2, D-Pen5] enkephalin
JP4081501B2 (ja)	2008-04-30	新規カッパレセプター選択的オピオイドペプチド
US5602100A (en)	1997-02-11	Dermorphin analogs having pharmacological activity
EP0125469A1 (en)	1984-11-21	Conformationally constrained cyclic enkephalin analogs with delta receptor specificity
SK83995A3 (en)	1996-09-04	New peptides
US20030032774A1 (en)	2003-02-13	Novel opioid peptides for the treatment of pain
MXPA98001192A (en)	1998-04-01	New opioid peptides
AU690648C (en)	1998-08-20	Novel opioid peptides for the treatment of pain and use thereof
TW380141B (en)	2000-01-21	Peptides for inhibiting pepsin release
RU2146681C1 (ru)	2000-03-20	Опиоидные пептиды и фармацевтическая композиция
EP1164141A2 (en)	2001-12-19	Opioid peptides and their use for treatment of pain
CA1340636C (en)	1999-07-06	Dermorphin analogs, their methods of preparation, pharmaceutical compositions and methods of therapeutic treatment using the same
JPS6054400A (ja)	1985-03-28	テトラペプチド
JPH10330399A (ja)	1998-12-15	神経伝達ポリペプチド
JPH07116234B2 (ja)	1995-12-13	新規ペプチド
JP2007261958A (ja)	2007-10-11	ペプチド誘導体