SK282003A3 - Pyrimidine derivatives, method for their preparation and pharmaceutical composition comprising the same - Google Patents

Pyrimidine derivatives, method for their preparation and pharmaceutical composition comprising the same Download PDF

Info

Publication number: SK282003A3
Authority: SK; Slovakia
Prior art keywords: group; sulfamoyl; alkyl; carbon atoms; cyano
Prior art date: 2000-07-11

Application number

SK28-2003A

Other languages

English (en)

Slovak (sk)

Inventor

Andrew Peter Thomas

Nicholas John Newcombe

David William Heaton

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-11

Filing date

2001-07-06

Publication date

2003-07-01

2001-07-06 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2003-07-01 Publication of SK282003A3 publication Critical patent/SK282003A3/sk

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Heart & Thoracic Surgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Vascular Medicine (AREA)
Dermatology (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

SK28-2003A 2000-07-11 2001-07-06 Pyrimidine derivatives, method for their preparation and pharmaceutical composition comprising the same SK282003A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0016877.3A GB0016877D0 (en)	2000-07-11	2000-07-11	Chemical compounds
PCT/GB2001/003084 WO2002004429A1 (en)	2000-07-11	2001-07-06	Pyrimidine derivatives

Publications (1)

Publication Number	Publication Date
SK282003A3 true SK282003A3 (en)	2003-07-01

Family

ID=9895337

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK28-2003A SK282003A3 (en)	2000-07-11	2001-07-06	Pyrimidine derivatives, method for their preparation and pharmaceutical composition comprising the same

Country Status (33)

Country	Link
US (1)	US6908920B2 (es)
EP (1)	EP1303496B9 (es)
JP (1)	JP2004502763A (es)
KR (1)	KR100783447B1 (es)
CN (1)	CN1196685C (es)
AR (1)	AR031251A1 (es)
AT (1)	ATE372988T1 (es)
AU (2)	AU2001269317B2 (es)
BG (1)	BG107451A (es)
BR (1)	BR0112420A (es)
CA (1)	CA2415486C (es)
CY (1)	CY1107807T1 (es)
CZ (1)	CZ200376A3 (es)
DE (1)	DE60130463T2 (es)
DK (1)	DK1303496T3 (es)
EE (1)	EE200300020A (es)
ES (1)	ES2292599T3 (es)
GB (1)	GB0016877D0 (es)
HK (1)	HK1054940A1 (es)
HU (1)	HUP0301722A3 (es)
IL (2)	IL153754A0 (es)
IS (1)	IS2521B (es)
MX (1)	MXPA03000254A (es)
NO (1)	NO325280B1 (es)
NZ (1)	NZ523357A (es)
PL (1)	PL360385A1 (es)
PT (1)	PT1303496E (es)
RU (1)	RU2299201C2 (es)
SK (1)	SK282003A3 (es)
TW (1)	TWI221470B (es)
UA (1)	UA75084C2 (es)
WO (1)	WO2002004429A1 (es)
ZA (1)	ZA200300079B (es)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9828511D0 (en)	1998-12-24	1999-02-17	Zeneca Ltd	Chemical compounds
GB9919778D0 (en)	1999-08-21	1999-10-27	Zeneca Ltd	Chemical compounds
GB0004890D0 (en)	2000-03-01	2000-04-19	Astrazeneca Uk Ltd	Chemical compounds
GB0004888D0 (en)	2000-03-01	2000-04-19	Astrazeneca Uk Ltd	Chemical compounds
GB0004887D0 (en)	2000-03-01	2000-04-19	Astrazeneca Uk Ltd	Chemical compounds
GB0004886D0 (en)	2000-03-01	2000-04-19	Astrazeneca Uk Ltd	Chemical compounds
GB0007371D0 (en)	2000-03-28	2000-05-17	Astrazeneca Uk Ltd	Chemical compounds
GB0021726D0 (en)	2000-09-05	2000-10-18	Astrazeneca Ab	Chemical compounds
GB0103926D0 (en)	2001-02-17	2001-04-04	Astrazeneca Ab	Chemical compounds
KR100874791B1 (ko) *	2001-05-29	2008-12-18	바이엘 쉐링 파마 악티엔게젤샤프트	Ｃｄｋ-억제 피리미딘, 그의 제조방법 및 약제로서의 용도
DE10212098A1 (de) *	2002-03-11	2003-10-23	Schering Ag	CDK inhibitorische Pyrimidine, deren Herstellung und Verwendung als Arzneimittel
GB0113041D0 (en)	2001-05-30	2001-07-18	Astrazeneca Ab	Chemical compounds
JP4460292B2 (ja) *	2001-10-17	2010-05-12	ベーリンガーインゲルハイムファルマゲゼルシャフトミットベシュレンクテルハフツングウントコンパニーコマンディトゲゼルシャフト	ピリミジン誘導体、これらの化合物を含む医薬組成物、その使用及びその調製方法
WO2003032994A2 (de) *	2001-10-17	2003-04-24	Boehringer Ingelheim Pharma Gmbh & Co. Kg	5-substituierte 4-amino-2-phenylamino-pyrimidinderivate und ihre verwendung als beta-amyloid modulatoren
TWI329105B (en)	2002-02-01	2010-08-21	Rigel Pharmaceuticals Inc	2,4-pyrimidinediamine compounds and their uses
US7776921B2 (en) *	2002-02-07	2010-08-17	University Of Tennessee Research Foundation	Treating benign prostate hyperplasia with SARMS
GB0205688D0 (en) *	2002-03-09	2002-04-24	Astrazeneca Ab	Chemical compounds
WO2003076434A1 (en) *	2002-03-09	2003-09-18	Astrazeneca Ab	4- imidazolyl substuited pyrimidine derivatives with cdk inhibitiory activity
GB0205690D0 (en)	2002-03-09	2002-04-24	Astrazeneca Ab	Chemical compounds
GB0205693D0 (en) *	2002-03-09	2002-04-24	Astrazeneca Ab	Chemical compounds
WO2003076437A1 (de) *	2002-03-11	2003-09-18	Schering Aktiengesellschaft	Cdk inhibitorische 2-heteroaryl-pyrimidine, deren herstellung und verwendung als arzneimittel
US7176310B1 (en)	2002-04-09	2007-02-13	Ucb Sa	Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents
JP2005528443A (ja)	2002-05-30	2005-09-22	バーテックス　ファーマシューティカルズ　インコーポレイテッド	Ｊａｋキナーゼおよびｃｄｋ２プロテインキナーゼのインヒビター
AU2003249369A1 (en)	2002-06-21	2004-01-06	Cellular Genomics, Inc.	Certain amino-substituted monocycles as kinase modulators
EP2130541A3 (en)	2002-07-29	2013-12-18	Rigel Pharmaceuticals, Inc.	Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds
AU2003265336B8 (en)	2002-07-29	2009-04-23	Rigel Pharmaceuticals, Inc.	Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds
UY27939A1 (es)	2002-08-21	2004-03-31	Glaxo Group Ltd	Compuestos
DE10239042A1 (de) *	2002-08-21	2004-03-04	Schering Ag	Makrozyclische Pyrimidine, deren Herstellung und Verwendung als Arzneimittel
CA2502970A1 (en) *	2002-11-28	2004-06-10	Schering Aktiengesellschaft	Chk-, pdk- and akt-inhibitory pyrimidines, their production and use as pharmaceutical agents
GB0311274D0 (en)	2003-05-16	2003-06-18	Astrazeneca Ab	Chemical compounds
GB0311276D0 (en)	2003-05-16	2003-06-18	Astrazeneca Ab	Chemical compounds
EP2243781A1 (en) *	2003-05-30	2010-10-27	Vertex Pharmaceuticals, Inc.	Pyrazolopyridine derivatives as inhibitors of JAK and CDK2 protein kinases
US7504396B2 (en)	2003-06-24	2009-03-17	Amgen Inc.	Substituted heterocyclic compounds and methods of use
KR101201603B1 (ko)	2003-07-30	2012-11-14	리겔 파마슈티칼스, 인크.	자가면역 질환의 치료 또는 예방에 사용하기 위한2,4-피리미딘디아민 화합물
TW200528101A (en)	2004-02-03	2005-09-01	Astrazeneca Ab	Chemical compounds
GB0402356D0 (en) *	2004-02-03	2004-03-10	Glaxo Group Ltd	Novel compounds
CA2566531A1 (en)	2004-05-18	2005-12-15	Rigel Pharmaceuticals, Inc.	Cycloalkyl substituted pyrimidinediamine compounds and their uses
EP1598343A1 (de) *	2004-05-19	2005-11-23	Boehringer Ingelheim International GmbH	2-Arylaminopyrimidine als PLK Inhibitoren
US7521457B2 (en) *	2004-08-20	2009-04-21	Boehringer Ingelheim International Gmbh	Pyrimidines as PLK inhibitors
EP1794134A1 (de) *	2004-09-29	2007-06-13	Bayer Schering Pharma Aktiengesellschaft	Substituierte 2-anilinopyrimidine als zellzyklus -kinase oder rezeptortyrosin-kinase inhibitoren, deren herstellung und verwendung als arzneimittel
GB2420559B (en)	2004-11-15	2008-08-06	Rigel Pharmaceuticals Inc	Stereoisomerically enriched 3-aminocarbonyl bicycloheptene pyrimidinediamine compounds and their uses
US7557207B2 (en)	2004-11-24	2009-07-07	Rigel Pharmaceuticals, Inc.	Spiro 2,4-pyrimidinediamine compounds and their uses
MX2007007272A (es) *	2004-12-17	2007-07-11	Astrazeneca Ab	4-(4-imidazol-4-il)pirimidin-2-ilamino)benzamidas como inhibidores de cdk.
CN101115761B (zh)	2005-01-19	2012-07-18	里格尔药品股份有限公司	2,4-嘧啶二胺化合物的前药及其应用
US20070203161A1 (en) *	2006-02-24	2007-08-30	Rigel Pharmaceuticals, Inc.	Compositions and methods for inhibition of the jak pathway
EP1904457B1 (en) *	2005-06-08	2017-09-06	Rigel Pharmaceuticals, Inc.	Compositions and methods for inhibition of the jak pathway
EP2301928A1 (en) *	2005-07-30	2011-03-30	AstraZeneca AB	Imidazolyl-pyrimidine compounds for use in the treatment of proliferative disorders
CA2623374A1 (en)	2005-09-30	2007-04-05	Astrazeneca Ab	Imidazo [1,2-a] pyridine having anti-cell-proliferation activity
JP2009528295A (ja)	2006-02-24	2009-08-06	ライジェルファーマシューティカルズ，インコーポレイテッド	Ｊａｋ経路の阻害のための組成物および方法
AR060890A1 (es)	2006-05-15	2008-07-23	Boehringer Ingelheim Int	Compuestos derivados de pirimidina y composicion farmaceutica en base a ellos
TW200811169A (en) *	2006-05-26	2008-03-01	Astrazeneca Ab	Chemical compounds
CA2653777A1 (en)	2006-06-15	2007-12-21	Boehringer Ingelheim International Gmbh	2-anilino-4-(heterocyclic)amino-pyrimidines
CN101506176A (zh)	2006-06-15	2009-08-12	贝林格尔.英格海姆国际有限公司	2-苯胺基-4-氨基亚烷基氨基嘧啶
DE102007010801A1 (de) *	2007-03-02	2008-09-04	Bayer Cropscience Ag	Diaminopyrimidine als Fungizide
MX2009011090A (es)	2007-04-18	2009-11-02	Pfizer Prod Inc	Derivados de sulfonil amida para el tratamiento del crecimiento celular anormal.
CA2693594A1 (en) *	2007-07-17	2009-01-22	Rigel Pharmaceuticals, Inc.	Cyclic amine substituted pyrimidinediamines as pkc inhibitors
CA2707653A1 (en) *	2007-12-03	2009-06-11	Boehringer Ingelheim International Gmbh	Diaminopyridines for the treatment of diseases which are characterised by excessive or anomal cell proliferation
US8138339B2 (en)	2008-04-16	2012-03-20	Portola Pharmaceuticals, Inc.	Inhibitors of protein kinases
BRPI0910921B1 (pt)	2008-04-16	2022-06-21	Portola Pharmaceuticals, Inc	Inibidores de proteína syk quinase, composição farmacêutica, kit e usos dos referidos inibidores
CN102105150B (zh)	2008-05-21	2014-03-12	阿里亚德医药股份有限公司	用作激酶抑制剂的磷衍生物
US9273077B2 (en)	2008-05-21	2016-03-01	Ariad Pharmaceuticals, Inc.	Phosphorus derivatives as kinase inhibitors
US11351168B1 (en)	2008-06-27	2022-06-07	Celgene Car Llc	2,4-disubstituted pyrimidines useful as kinase inhibitors
MX357627B (es) *	2008-06-27	2018-07-17	Avila Therapeutics Inc	Compuestos de heteroarilo y usos de los mismos.
US8338439B2 (en)	2008-06-27	2012-12-25	Celgene Avilomics Research, Inc.	2,4-disubstituted pyrimidines useful as kinase inhibitors
KR20110049902A (ko) *	2008-09-01	2011-05-12	아스텔라스세이야쿠 가부시키가이샤	2,4-디아미노피리미딘 화합물
CN102203086A (zh) *	2008-09-03	2011-09-28	拜尔农作物科学股份公司	作为杀真菌剂的噻吩基氨基嘧啶类化合物
EP2161259A1 (de)	2008-09-03	2010-03-10	Bayer CropScience AG	4-Halogenalkylsubstituierte Diaminopyrimidine als Fungizide
EP2179993A1 (de)	2008-10-21	2010-04-28	Bayer Schering Pharma Aktiengesellschaft	Sulfoxidsubstituierte Anilinopyrimidinderivative als CDK-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
EP2179992A1 (de)	2008-10-21	2010-04-28	Bayer Schering Pharma Aktiengesellschaft	Sulfonsubstituierte Anlinopyrimidinderivative als CDK-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
EP2179991A1 (de)	2008-10-21	2010-04-28	Bayer Schering Pharma Aktiengesellschaft	Sulfoximinsubstituierte Anilino-Pyrimidinderivate als CDK-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
AR074210A1 (es)	2008-11-24	2010-12-29	Boehringer Ingelheim Int	Derivados de pirimidina como inhibidores de ptk2-quinasa
TW201024281A (en)	2008-11-24	2010-07-01	Boehringer Ingelheim Int	New compounds
DE102009001438A1 (de)	2009-03-10	2010-09-16	Bayer Schering Pharma Aktiengesellschaft	Carbonylamino-substituierte Anilino-Pyrimidinderivate als Tyk-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
DE102009015070A1 (de)	2009-03-30	2010-10-14	Bayer Schering Pharma Aktiengesellschaft	Aminocabonylamino-substituierte Anilino-Pyrimidinderivate als Tyk-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
BR112012002001A2 (pt) *	2009-07-28	2016-05-10	Rigel Pharmaceuticals Inc	método para tratar uma doença e/ou distúrbio do olho, formulação farmacêutica, e, kit
US8933227B2 (en)	2009-08-14	2015-01-13	Boehringer Ingelheim International Gmbh	Selective synthesis of functionalized pyrimidines
US8729265B2 (en)	2009-08-14	2014-05-20	Boehringer Ingelheim International Gmbh	Regioselective preparation of 2-amino-5-trifluoromethylpyrimidine derivatives
DE102010014427A1 (de)	2010-04-01	2011-10-06	Bayer Schering Pharma Aktiengesellschaft	Kombinationen neuer pan-CDK-Inhibitoren zur Behandlung von Tumoren
DE102010014426A1 (de)	2010-04-01	2011-10-06	Bayer Schering Pharma Aktiengesellschaft	Verwendung neuer pan-CDK-Inhibitoren zur Behandlung von Tumoren
PT2576541T (pt)	2010-06-04	2016-07-08	Hoffmann La Roche	Derivados de aminopirimidina como moduladores de lrrk2
US8343954B2 (en)	2010-07-28	2013-01-01	Rigel Pharmaceuticals, Inc.	Compositions and methods for inhibition of the JAK pathway
US8975249B2 (en)	2010-11-01	2015-03-10	Celgene Avilomics Research, Inc.	Heterocyclic compounds and uses thereof
RS59106B1 (sr)	2010-11-10	2019-09-30	Genentech Inc	Derivati pirazol aminopirimidina kao lrrk2 modulatori
TWI681952B (zh) *	2011-04-22	2020-01-11	美商標誌製藥公司	經取代之二胺基甲醯胺及二胺基甲腈嘧啶、其組合物、及以該等治療之方法
AU2012250517B2 (en)	2011-05-04	2016-05-19	Takeda Pharmaceutical Company Limited	Compounds for inhibiting cell proliferation in EGFR-driven cancers
GEP20156397B (en) *	2011-05-06	2015-11-10	Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság	Process for the preparation of a rivaroxaban and intermediates formed in said process
US9359308B2 (en)	2011-11-23	2016-06-07	Portola Pharmaceuticals, Inc.	Pyrazine kinase inhibitors
MX349556B (es) *	2011-11-29	2017-08-03	Genentech Inc	Derivados de aminopirimidina como moduladores de proteina cinasa 2 rica en unidades repetitivas de leucina (lrrk2).
ES2698298T3 (es)	2012-03-15	2019-02-04	Celgene Car Llc	Sales de un inhibidor de quinasa receptor de factor de crecimiento epidérmico
JP6317319B2 (ja)	2012-03-15	2018-04-25	セルジーンシーエーアールエルエルシー	上皮成長因子受容体キナーゼ阻害剤の固体形態
AP2014007915A0 (en)	2012-03-21	2014-09-30	Bayer Ip Gmbh	Use of (RS)-S-cyclopropyl-S-(4-{[4-{[1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-YL]amino}phenyl)suloximide for treating specific tumours
AU2013204563B2 (en)	2012-05-05	2016-05-19	Takeda Pharmaceutical Company Limited	Compounds for inhibiting cell proliferation in EGFR-driven cancers
EP2852579A4 (en) *	2012-05-22	2015-12-30	Univ North Carolina	PYRIMIDINE COMPOUNDS FOR CANCER TREATMENT
US9611283B1 (en)	2013-04-10	2017-04-04	Ariad Pharmaceuticals, Inc.	Methods for inhibiting cell proliferation in ALK-driven cancers
WO2014173815A1 (en)	2013-04-23	2014-10-30	Bayer Pharma Aktiengesellschaft	Use of (rs)-s-cyclopropyl-s-(4-{[4-{[(1r, 2r)-2-hydroxy-1-methylpropyl]oxy}-5- (trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulphoximide for the treatment of specific tumours
ES2812605T3 (es)	2013-12-20	2021-03-17	Signal Pharm Llc	Compuestos de diaminopirimidilo sustituidos, composiciones de los mismos y procedimientos de tratamiento con ellos
CN110372584A (zh) *	2019-06-25	2019-10-25	南京普锐达医药科技有限公司	一种2,4-二氯-6-氰基嘧啶的合成方法
CN110452179A (zh) *	2019-06-25	2019-11-15	南京普锐达医药科技有限公司	一种2-氯-4-甲氧基-5-氰基嘧啶的合成方法
CN112110863A (zh) *	2020-08-27	2020-12-22	中山大学	一种磺酰氟类化合物、其制备方法以及通过其制备磺酰胺类化合物的方法
JP2024506116A (ja) *	2020-11-27	2024-02-09	オールオリオンセラピューティクスインコーポレイテッド	アミノヘテロアリールキナーゼ阻害剤
WO2024243485A1 (en) *	2023-05-25	2024-11-28	Odyssey Therapeutics, Inc.	Cdk2 inhibitors and uses thereof

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4659363A (en)	1983-07-25	1987-04-21	Ciba-Geigy Corporation	N-(2-nitrophenyl)-2-aminopyrimidine derivatives, the preparation and use thereof
US4946956A (en)	1988-09-21	1990-08-07	Uniroyal Chemical Company, Inc.	Arylenediamine substituted pyrimidines
HU206337B (en)	1988-12-29	1992-10-28	Mitsui Petrochemical Ind	Process for producing pyrimidine derivatives and pharmaceutical compositions
US4983608A (en)	1989-09-05	1991-01-08	Hoechst-Roussell Pharmaceuticals, Inc.	N-substituted-4-pyrimidinamines and pyrimidinediamines
GB9012592D0 (en)	1990-06-06	1990-07-25	Smithkline Beecham Intercredit	Compounds
SG64322A1 (en)	1991-05-10	1999-04-27	Rhone Poulenc Rorer Int	Bis mono and bicyclic aryl and heteroaryl compounds which inhibit egf and/or pdgf receptor tyrosine kinase
US5521184A (en)	1992-04-03	1996-05-28	Ciba-Geigy Corporation	Pyrimidine derivatives and processes for the preparation thereof
US5516775A (en)	1992-08-31	1996-05-14	Ciba-Geigy Corporation	Further use of pyrimidine derivatives
CA2146333A1 (en)	1992-10-05	1994-04-14	Tomio Kimura	Pyrimidine compound
JP3588116B2 (ja)	1993-10-01	2004-11-10	ノバルティスアクチェンゲゼルシャフト	薬理活性のピリミジンアミン誘導体およびその製造方法
US5543520A (en)	1993-10-01	1996-08-06	Ciba-Geigy Corporation	Pyrimidine derivatives
CN1047776C (zh)	1993-10-01	1999-12-29	诺瓦蒂斯有限公司	具有药理学活性的吡啶类衍生物及其制备方法
JPH08503971A (ja)	1993-10-01	1996-04-30	チバ−ガイギーアクチェンゲゼルシャフト	ピリミジンアミン誘導体及びその調製のための方法
GB9325217D0 (en)	1993-12-09	1994-02-09	Zeneca Ltd	Pyrimidine derivatives
EP0775120B1 (en)	1994-08-13	2003-06-04	Yuhan Corporation	Novel pyrimidine derivatives and processes for the preparation thereof
ES2208737T3 (es)	1995-03-10	2004-06-16	Berlex Laboratories, Inc.	Derivados de benzamidina, su preparacion y su utilizacion como anticoagulantes.
US5739143A (en)	1995-06-07	1998-04-14	Smithkline Beecham Corporation	Imidazole compounds and compositions
IL118544A (en)	1995-06-07	2001-08-08	Smithkline Beecham Corp	History of imidazole, the process for their preparation and the pharmaceutical preparations containing them
GB9523675D0 (en)	1995-11-20	1996-01-24	Celltech Therapeutics Ltd	Chemical compounds
US6096739A (en)	1996-03-25	2000-08-01	Smithkline Beecham Corporation	Treatment for CNS injuries
JP2000511883A (ja)	1996-04-19	2000-09-12	ノボノルディスクアクティーゼルスカブ	ホスホチロシン認識ユニットを有する分子のモジュレーター
TW440563B (en)	1996-05-23	2001-06-16	Hoffmann La Roche	Aryl pyrimidine derivatives and a pharmaceutical composition thereof
DE69733135T2 (de)	1996-06-10	2006-03-02	Merck & Co., Inc.	Substituierte imidazole mit cytokinin-inhibirender wirkung
US5866702A (en) *	1996-08-02	1999-02-02	Cv Therapeutics, Incorporation	Purine inhibitors of cyclin dependent kinase 2
GB9619284D0 (en)	1996-09-16	1996-10-30	Celltech Therapeutics Ltd	Chemical compounds
AU5147598A (en)	1996-10-17	1998-05-11	Smithkline Beecham Corporation	Methods for reversibly inhibiting myelopoiesis in mammalian tissue
GB9622363D0 (en)	1996-10-28	1997-01-08	Celltech Therapeutics Ltd	Chemical compounds
ZA9711092B (en)	1996-12-11	1999-07-22	Smithkline Beecham Corp	Novel compounds.
BR9807305A (pt)	1997-02-05	2000-05-02	Warner Lambert Co	Pirido [2,3-d] pirimidinas e 4-aminopirimidinas como inibidores de proliferação celular.
DE19710435A1 (de)	1997-03-13	1998-09-17	Hoechst Ag	Verwendung von Pyrimidinderivaten zur Prävention von Krebs allein oder in Kombination mit anderen therapeutischen Maßnahmen
GB9705361D0 (en)	1997-03-14	1997-04-30	Celltech Therapeutics Ltd	Chemical compounds
WO1998054093A1 (en)	1997-05-30	1998-12-03	Merck & Co., Inc.	Novel angiogenesis inhibitors
CZ9904452A3 (cs)	1997-06-12	2002-02-13	Rhone-Poulenc Rorer Limited	Cyklické acetaly imidazolylu, způsob jejich přípravy, jejich pouľití a farmaceutický prostředek, který je obsahuje
TW517055B (en)	1997-07-02	2003-01-11	Smithkline Beecham Corp	Novel substituted imidazole compounds
EP1003746A1 (en) *	1997-08-07	2000-05-31	The Regents Of The University Of California	Purine inhibitor of protein kinases, g proteins and polymerases
JP2001519345A (ja)	1997-10-02	2001-10-23	メルクエンドカムパニーインコーポレーテッド	プレニルタンパク質トランスフェラーゼの阻害剤
AU9449398A (en)	1997-10-10	1999-05-03	Imperial College Innovations Ltd.	Use of csaidtm compounds for the management of uterine contractions
AU1507199A (en)	1997-12-15	1999-07-05	Yamanouchi Pharmaceutical Co., Ltd.	Novel pyrimidine-5-carboxamide derivatives
WO1999032121A1 (en)	1997-12-19	1999-07-01	Smithkline Beecham Corporation	Compounds of heteroaryl substituted imidazole, their pharmaceutical compositions and uses
CA2321153A1 (en)	1998-02-17	1999-08-19	Timothy D. Cushing	Anti-viral pyrimidine derivatives
ATE232521T1 (de)	1998-03-27	2003-02-15	Janssen Pharmaceutica Nv	Hiv hemmende pyrimidin derivate
GB9806739D0 (en) *	1998-03-28	1998-05-27	Univ Newcastle Ventures Ltd	Cyclin dependent kinase inhibitors
AU5438499A (en)	1998-08-29	2000-03-21	Astrazeneca Ab	Pyrimidine compounds
WO2000012485A1 (en)	1998-08-29	2000-03-09	Astrazeneca Ab	Pyrimidine compounds
WO2000017203A1 (en)	1998-09-18	2000-03-30	Basf Aktiengesellschaft	Pyrrolopyrimidines as protein kinase inhibitors
BR9913888A (pt)	1998-09-18	2002-01-08	Basf Ag	Composto, e, métodos de inibir a atividade da proteìna quinase, de tratar um paciente que tenha uma condição que seja mediada pela atividade da proteìna quinase e de diminuir a fertilidade em um paciente
US6531477B1 (en)	1998-10-13	2003-03-11	Dupont Pharmaceuticals Company	6-substituted pyrazolo [3,4-d] pyrimidin-4-ones useful as cyclin dependent kinase inhibitors
CA2348234A1 (en)	1998-10-29	2000-05-11	Chunjian Liu	Compounds derived from an amine nucleus that are inhibitors of impdh enzyme
AU6476599A (en)	1998-11-03	2000-05-22	Novartis Ag	Anti-inflammatory 4-phenyl-5-pyrimidinyl-imidazoles
GB9828511D0 (en) *	1998-12-24	1999-02-17	Zeneca Ltd	Chemical compounds
CZ20012765A3 (cs)	1999-02-01	2002-08-14	Cv Therapeutics, Inc.	Purinové inhibitory kinasy 2 a Ikappa - Aalfa dependentní na cyklinu
GB9903762D0 (en)	1999-02-18	1999-04-14	Novartis Ag	Organic compounds
GB9905075D0 (en)	1999-03-06	1999-04-28	Zeneca Ltd	Chemical compounds
US6627633B2 (en)	1999-03-17	2003-09-30	Albany Molecular Research, Inc.	6-substituted biaryl purine derivatives as potent cyclin/CDK inhibitors and antiproliferative agents
GB9907658D0 (en)	1999-04-06	1999-05-26	Zeneca Ltd	Chemical compounds
GB9914258D0 (en)	1999-06-18	1999-08-18	Celltech Therapeutics Ltd	Chemical compounds
GB9919778D0 (en)	1999-08-21	1999-10-27	Zeneca Ltd	Chemical compounds
GB9924862D0 (en)	1999-10-20	1999-12-22	Celltech Therapeutics Ltd	Chemical compounds
AU7922900A (en)	1999-10-27	2001-05-08	Novartis Ag	Thiazole and imidazo (4,5-b) pyridine compounds and their pharmaceutical use
ATE382044T1 (de)	1999-11-22	2008-01-15	Smithkline Beecham Plc	Imidazol- derivate
ES2335265T3 (es)	1999-12-28	2010-03-24	Pharmacopeia, Inc.	Inhibidores de citoquina, especialmente de tnf-alfa.
KR20030024659A (ko)	2000-02-17	2003-03-26	암겐 인코포레이티드	키나제 억제제
GB0004888D0 (en)	2000-03-01	2000-04-19	Astrazeneca Uk Ltd	Chemical compounds
GB0004887D0 (en)	2000-03-01	2000-04-19	Astrazeneca Uk Ltd	Chemical compounds
GB0004886D0 (en)	2000-03-01	2000-04-19	Astrazeneca Uk Ltd	Chemical compounds
GB0004890D0 (en)	2000-03-01	2000-04-19	Astrazeneca Uk Ltd	Chemical compounds
GB0007371D0 (en)	2000-03-28	2000-05-17	Astrazeneca Uk Ltd	Chemical compounds
GB0021726D0 (en)	2000-09-05	2000-10-18	Astrazeneca Ab	Chemical compounds
GB0103926D0 (en)	2001-02-17	2001-04-04	Astrazeneca Ab	Chemical compounds
GB0113041D0 (en)	2001-05-30	2001-07-18	Astrazeneca Ab	Chemical compounds
AU2002316421B2 (en) *	2001-06-26	2008-05-15	Bristol-Myers Squibb Company	N-heterocyclic inhibitors of TNF-ALPHA expression

2000
- 2000-07-11 GB GBGB0016877.3A patent/GB0016877D0/en not_active Ceased
2001
- 2001-06-07 UA UA2003021194A patent/UA75084C2/uk unknown
- 2001-07-06 HU HU0301722A patent/HUP0301722A3/hu unknown
- 2001-07-06 WO PCT/GB2001/003084 patent/WO2002004429A1/en active IP Right Grant
- 2001-07-06 EE EEP200300020A patent/EE200300020A/xx unknown
- 2001-07-06 CA CA002415486A patent/CA2415486C/en not_active Expired - Fee Related
- 2001-07-06 AU AU2001269317A patent/AU2001269317B2/en not_active Ceased
- 2001-07-06 JP JP2002509296A patent/JP2004502763A/ja active Pending
- 2001-07-06 CN CNB018153623A patent/CN1196685C/zh not_active Expired - Fee Related
- 2001-07-06 AT AT01947671T patent/ATE372988T1/de not_active IP Right Cessation
- 2001-07-06 NZ NZ523357A patent/NZ523357A/en unknown
- 2001-07-06 KR KR1020037000437A patent/KR100783447B1/ko not_active IP Right Cessation
- 2001-07-06 DE DE60130463T patent/DE60130463T2/de not_active Expired - Lifetime
- 2001-07-06 PL PL36038501A patent/PL360385A1/xx not_active Application Discontinuation
- 2001-07-06 CZ CZ200376A patent/CZ200376A3/cs unknown
- 2001-07-06 SK SK28-2003A patent/SK282003A3/sk not_active IP Right Cessation
- 2001-07-06 ES ES01947671T patent/ES2292599T3/es not_active Expired - Lifetime
- 2001-07-06 IL IL15375401A patent/IL153754A0/xx active IP Right Grant
- 2001-07-06 BR BR0112420-0A patent/BR0112420A/pt not_active Application Discontinuation
- 2001-07-06 AU AU6931701A patent/AU6931701A/xx active Pending
- 2001-07-06 DK DK01947671T patent/DK1303496T3/da active
- 2001-07-06 US US10/332,275 patent/US6908920B2/en not_active Expired - Fee Related
- 2001-07-06 EP EP01947671A patent/EP1303496B9/en not_active Expired - Lifetime
- 2001-07-06 PT PT01947671T patent/PT1303496E/pt unknown
- 2001-07-06 RU RU2003103848/04A patent/RU2299201C2/ru not_active IP Right Cessation
- 2001-07-06 MX MXPA03000254A patent/MXPA03000254A/es active IP Right Grant
- 2001-07-10 TW TW090116869A patent/TWI221470B/zh not_active IP Right Cessation
- 2001-07-11 AR ARP010103279A patent/AR031251A1/es not_active Application Discontinuation
2002
- 2002-12-30 IL IL153754A patent/IL153754A/en not_active IP Right Cessation
2003
- 2003-01-03 ZA ZA200300079A patent/ZA200300079B/en unknown
- 2003-01-08 IS IS6672A patent/IS2521B/is unknown
- 2003-01-08 BG BG107451A patent/BG107451A/bg unknown
- 2003-01-10 NO NO20030146A patent/NO325280B1/no not_active IP Right Cessation
- 2003-10-09 HK HK03107264A patent/HK1054940A1/xx not_active IP Right Cessation
2007
- 2007-11-19 CY CY20071101483T patent/CY1107807T1/el unknown

Also Published As

Publication number	Publication date
HK1054940A1 (en)	2003-12-19
CY1107807T1 (el)	2013-06-19
ATE372988T1 (de)	2007-09-15
MXPA03000254A (es)	2004-12-13
HUP0301722A2 (hu)	2003-12-29
HUP0301722A3 (en)	2004-03-29
KR20030020925A (ko)	2003-03-10
EP1303496A1 (en)	2003-04-23
PT1303496E (pt)	2007-11-28
US6908920B2 (en)	2005-06-21
IL153754A (en)	2008-04-13
CA2415486A1 (en)	2002-01-17
UA75084C2 (en)	2006-03-15
CA2415486C (en)	2009-12-08
IL153754A0 (en)	2003-07-06
EP1303496B1 (en)	2007-09-12
EP1303496B9 (en)	2008-03-19
IS6672A (is)	2003-01-08
AU2001269317B2 (en)	2006-08-31
CN1196685C (zh)	2005-04-13
NO20030146D0 (no)	2003-01-10
JP2004502763A (ja)	2004-01-29
CN1454210A (zh)	2003-11-05
ES2292599T3 (es)	2008-03-16
KR100783447B1 (ko)	2007-12-07
BG107451A (bg)	2003-09-30
AU6931701A (en)	2002-01-21
IS2521B (is)	2009-07-15
DE60130463T2 (de)	2008-06-05
NO325280B1 (no)	2008-03-17
NZ523357A (en)	2004-07-30
DK1303496T3 (da)	2007-12-27
PL360385A1 (en)	2004-09-06
AR031251A1 (es)	2003-09-17
RU2299201C2 (ru)	2007-05-20
BR0112420A (pt)	2003-06-24
CZ200376A3 (cs)	2003-04-16
NO20030146L (no)	2003-01-10
US20030216406A1 (en)	2003-11-20
WO2002004429A1 (en)	2002-01-17
ZA200300079B (en)	2004-05-05
GB0016877D0 (en)	2000-08-30
TWI221470B (en)	2004-10-01
DE60130463D1 (de)	2007-10-25
EE200300020A (et)	2004-10-15

Publication	Publication Date	Title
US6908920B2 (en)	2005-06-21	Pyrimidine derivatives
US6906065B2 (en)	2005-06-14	4-Amino-5-cyano-2-anilino-pyrimidine derivatives and their use as inhibitors of cell-cycle kinases
US6939872B2 (en)	2005-09-06	2-anilino-pyrimidine derivatives as cyclin dependent kinase inhibitors
JP4913305B2 (ja)	2012-04-11	ピリミジン化合物
US20090099160A1 (en)	2009-04-16	4-(4-(Imidazol-4-Yl) Pyrimidin-2-Ylamino) Benzamides as CDK Inhibitors
BG65566B1 (bg)	2008-12-30	Производни на имидазо[1,2-a] пиридин и пиразоло[2,3-a]пиридин
CZ2003617A3 (cs)	2003-06-18	Deriváty imidazol-5-yl-2-anilinopyrimidinů, způsob jejich přípravy a farmaceutický prostředek, který je obsahuje
PT1278735E (pt)	2010-08-12	2,4-di(hetero-)arilamino(-oxi)-pirimidinas substituídas na posição 5 como agentes antineoplásicos
AU2001239414A1 (en)	2001-12-20	4-amino-5-cyano-2-anilino-pyrimidine derivatives and their use as inhibitors of cell-cycle kinases
AU2001269317A1 (en)	2002-04-18	Pyrimidine derivatives
JP2004502763A5 (es)	2008-08-28
BR122014024864B1 (pt)	2019-04-02	Derivado de pirimidina, processo para preparar um derivado de pirimidina, composição farmacêutica, e, uso de um derivado de pirimidina

Legal Events

Date	Code	Title	Description
2010-10-07	FC9A	Refused patent application
2014-10-03	MK4A	Expiry of patent	Expiry date: 20140816