[go: up one dir, main page]

SK136797A3 - Substituted 1-phenylpyrazole-3-carboxamides acting on neurotensin receptors, a method for the preparation of them, and pharmaceutical compositions containing them - Google Patents

Substituted 1-phenylpyrazole-3-carboxamides acting on neurotensin receptors, a method for the preparation of them, and pharmaceutical compositions containing them Download PDF

Info

Publication number
SK136797A3
SK136797A3 SK1367-97A SK136797A SK136797A3 SK 136797 A3 SK136797 A3 SK 136797A3 SK 136797 A SK136797 A SK 136797A SK 136797 A3 SK136797 A3 SK 136797A3
Authority
SK
Slovakia
Prior art keywords
group
alkyl
carbon atoms
alk
formula
Prior art date
Application number
SK1367-97A
Other languages
English (en)
Slovak (sk)
Inventor
Bernard Labeeuw
Danielle Gully
Francis Jeanjean
Jean-Charles Molimard
Robert Boigegrain
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of SK136797A3 publication Critical patent/SK136797A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10—Hydrazines
    • C07C243/22—Hydrazines having nitrogen atoms of hydrazine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/63—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C255/65—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton with the nitrogen atoms further bound to nitrogen atoms
    • C07C255/66—Carboxylic acid nitriles containing cyano groups and nitrogen atoms further bound to other hetero atoms, other than oxygen atoms of nitro or nitroso groups, bound to the same carbon skeleton with the nitrogen atoms further bound to nitrogen atoms having cyano groups and nitrogen atoms being part of hydrazine or hydrazone groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/47—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton having at least one of the sulfo groups bound to a carbon atom of a six-membered aromatic ring being part of a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SK1367-97A 1995-04-11 1996-04-11 Substituted 1-phenylpyrazole-3-carboxamides acting on neurotensin receptors, a method for the preparation of them, and pharmaceutical compositions containing them SK136797A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9504350A FR2732967B1 (fr) 1995-04-11 1995-04-11 1-phenylpyrazole-3-carboxamides substitues, actifs sur la neurotensine, leur preparation, les compositions pharmaceutiques en contenant
PCT/FR1996/000546 WO1996032382A1 (fr) 1995-04-11 1996-04-11 1-phenylpyrazole-3-carboxamides actifs sur les recepteurs de la neurotensine

Publications (1)

Publication Number Publication Date
SK136797A3 true SK136797A3 (en) 1998-07-08

Family

ID=9478010

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1367-97A SK136797A3 (en) 1995-04-11 1996-04-11 Substituted 1-phenylpyrazole-3-carboxamides acting on neurotensin receptors, a method for the preparation of them, and pharmaceutical compositions containing them

Country Status (26)

Country Link
US (6) US5723483A (no)
EP (2) EP0820444A1 (no)
JP (1) JP3061644B2 (no)
KR (1) KR100366118B1 (no)
CN (1) CN1072210C (no)
AR (1) AR003940A1 (no)
AU (1) AU709119B2 (no)
CA (1) CA2220827A1 (no)
CZ (1) CZ292255B6 (no)
EE (1) EE9700264A (no)
FR (1) FR2732967B1 (no)
HU (1) HUP9801435A3 (no)
IL (1) IL117860A0 (no)
IN (1) IN185700B (no)
IS (1) IS4582A (no)
MY (1) MY114424A (no)
NO (1) NO310071B1 (no)
NZ (1) NZ307227A (no)
PL (1) PL188077B1 (no)
RU (1) RU2195455C2 (no)
SK (1) SK136797A3 (no)
TR (1) TR199701146T1 (no)
TW (1) TW411332B (no)
UA (1) UA66750C2 (no)
WO (1) WO1996032382A1 (no)
ZA (1) ZA962886B (no)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2732967B1 (fr) 1995-04-11 1997-07-04 Sanofi Sa 1-phenylpyrazole-3-carboxamides substitues, actifs sur la neurotensine, leur preparation, les compositions pharmaceutiques en contenant
AU4229999A (en) * 1998-06-05 1999-12-20 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted 1-(4-aminophenyl)pyrazoles and their use as anti-inflammatory agents
DE10146867A1 (de) * 2001-09-24 2003-04-24 Bayer Ag Tetrahydroisochinoline
AU2003223708A1 (en) * 2002-04-23 2003-11-10 Axys Pharmaceuticals, Inc. Novel phenyl derivatives as inducers of apoptosis
GB0225548D0 (en) * 2002-11-01 2002-12-11 Glaxo Group Ltd Compounds
FR2847160A1 (fr) * 2002-11-20 2004-05-21 Oreal Composition capillaire contenant un compose pyrasol-carboxamide, son utilisation pour stimuler la pousse des cheveux et/ou freiner leur chute
ES2265596T3 (es) 2002-11-27 2007-02-16 Boehringer Ingelheim Pharmaceuticals Inc. Derivados de 1,2,3-triazol-amida como inhibidores de citocinas.
US7078419B2 (en) 2003-03-10 2006-07-18 Boehringer Ingelheim Pharmaceuticals, Inc. Cytokine inhibitors
US20060079566A1 (en) * 2003-10-03 2006-04-13 Ching-Shih Chen PDK-1/Akt signaling inhibitors
GB0323584D0 (en) * 2003-10-08 2003-11-12 Glaxo Group Ltd Compounds
GB0323585D0 (en) * 2003-10-08 2003-11-12 Glaxo Group Ltd Compounds
JP2007518686A (ja) * 2003-10-17 2007-07-12 田辺製薬株式会社 高コンダクタンス型カルシウム感受性ｋチャネル開口薬
DE602004031759D1 (de) 2003-12-03 2011-04-21 Boehringer Ingelheim Pharma 1,2,3-triazolamidderivate als inhibitoren der cytokinproduktion
US20090149463A1 (en) * 2004-02-20 2009-06-11 Leifeng Cheng Therapeutic agents
PL1725544T3 (pl) 2004-03-09 2009-10-30 Boehringer Ingelheim Pharmaceuticals Inc 3-[4-Heterocyklilo-1,2,3-triazol-1-ilo]-N-arylobenzamidy jako inhibitory wytwarzania cytokin, do leczenia przewlekłych chorób zapalnych
CA2560387C (en) 2004-05-03 2013-09-24 Boehringer Ingelheim Pharmaceuticals, Inc. Cytokine inhibitors
GB0410121D0 (en) * 2004-05-06 2004-06-09 Glaxo Group Ltd Compounds
US7485657B2 (en) * 2004-05-12 2009-02-03 Boehringer Ingelheim Pharmaceuticals, Inc. Anti-cytokine heterocyclic compounds
US7531560B2 (en) * 2004-11-10 2009-05-12 Boehringer Ingelheim Pharmaceuticals, Inc. Anti-cytokine heterocyclic compounds
WO2006067443A1 (en) * 2004-12-23 2006-06-29 Astrazeneca Ab Therapeutic agents
GB0514738D0 (en) * 2005-07-19 2005-08-24 Astrazeneca Ab Therapeutic agents
US20100113776A1 (en) * 2006-12-14 2010-05-06 Taisho Pharmaceutical Co.,Ltd. Pyrazole derivative
US8586043B2 (en) 2009-01-07 2013-11-19 Inserm ( Institut National De La Sante Et De La Recherche Medicale) Methods for treating breast cancer with inhibitors of neurotensin activation of NTSR1
US20120135997A1 (en) 2009-07-17 2012-05-31 Shionogi & Co., Ltd. Pharmaceutical composition comprising a lactam or benzenesulfonamide compound
US20110028624A1 (en) * 2009-07-30 2011-02-03 Genovique Specialties Holdings Corporation Polymer Compositions That Include High Solvating Plasticizer And Surfactant
EP2740726A1 (en) 2012-12-07 2014-06-11 3B Pharmaceuticals GmbH Neurotensin receptor ligands
WO2015148465A1 (en) * 2014-03-25 2015-10-01 Research Triangle Institute Pyrazole compounds selective for neurotensin 2 receptor
CN106459004B (zh) 2014-06-06 2020-09-15 研究三角协会 爱帕琳肽受体(apj)激动剂及其用途
EP2954933A1 (en) 2014-06-10 2015-12-16 3B Pharmaceuticals GmbH Conjugate comprising a neurotensin receptor ligand
WO2015188934A1 (en) 2014-06-10 2015-12-17 3B Pharmaceuticals Gmbh Conjugate comprising a neurotensin receptor ligand and use thereof
EP2954934A1 (en) 2014-06-11 2015-12-16 3B Pharmaceuticals GmbH Conjugate comprising a neurotensin receptor ligand and use thereof
AU2016366310C1 (en) 2015-12-09 2021-09-09 Research Triangle Institute Improved apelin receptor (APJ) agonists and uses thereof
EP3279197A1 (en) 2016-08-03 2018-02-07 Friedrich-Alexander-Universität Erlangen-Nürnberg Diagnosis, treatment and prevention of neurotensin receptor-related conditions
GB201815695D0 (en) 2018-09-26 2018-11-07 Mereo Biopharma 1 Ltd Synthetic method
GB201815696D0 (en) * 2018-09-26 2018-11-07 Mereo Biopharma 1 Ltd Synthetic method
KR20240150464A (ko) * 2022-02-18 2024-10-15 풀-라이프 테크놀로지스 에이치케이 리미티드 뉴로텐신 수용체를 표적화하기 위한 화합물 및 방사선리간드 및 이의 용도
US12091454B2 (en) 2022-12-28 2024-09-17 Development Center For Biotechnology Humanized anti-human neurotensin receptor 1 antibodies and their uses

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE258017C (no) *
DE404647C (de) * 1922-11-18 1924-10-20 Chemische Ind Ges Verfahren zur Herstellung von Pyrazolonfarbstoffen
US3520926A (en) * 1966-11-14 1970-07-21 Hoffmann La Roche Methylhydrazinomethyl-substituted benzoic acid amides
US4105766A (en) * 1977-08-19 1978-08-08 Sterling Drug Inc. 4,5-Dihydro-5-oxopyrazolo[1,5-a]quinazoline-3-carboxylic acid derivatives
FR2665898B1 (fr) * 1990-08-20 1994-03-11 Sanofi Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2692575B1 (fr) * 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2711140B1 (fr) * 1993-10-12 1996-01-05 Sanofi Sa 1-Naphtylpyrazole-3-carboxamides substitués actifs sur la neurotensine, leur préparation, les compositions pharmaceutiques en contenant.
FR2732967B1 (fr) 1995-04-11 1997-07-04 Sanofi Sa 1-phenylpyrazole-3-carboxamides substitues, actifs sur la neurotensine, leur preparation, les compositions pharmaceutiques en contenant

Also Published As

Publication number Publication date
AR003940A1 (es) 1998-09-30
IN185700B (no) 2001-04-07
CZ323297A3 (cs) 1998-02-18
TR199701146T1 (xx) 1998-02-21
AU709119B2 (en) 1999-08-19
ZA962886B (en) 1996-10-15
NO974702D0 (no) 1997-10-10
KR100366118B1 (ko) 2003-03-15
EE9700264A (et) 1998-04-15
CN1184469A (zh) 1998-06-10
US5723483A (en) 1998-03-03
US5936123A (en) 1999-08-10
WO1996032382A1 (fr) 1996-10-17
US5925661A (en) 1999-07-20
CN1072210C (zh) 2001-10-03
EP0820444A1 (fr) 1998-01-28
HUP9801435A2 (hu) 1998-10-28
PL188077B1 (pl) 2004-12-31
CZ292255B6 (cs) 2003-08-13
FR2732967A1 (fr) 1996-10-18
PL322723A1 (en) 1998-02-16
CA2220827A1 (en) 1996-10-17
NO974702L (no) 1997-12-10
AU5651696A (en) 1996-10-30
UA66750C2 (en) 2004-06-15
EP1097921A1 (fr) 2001-05-09
US5939449A (en) 1999-08-17
NZ307227A (en) 2000-01-28
IS4582A (is) 1997-10-09
JP3061644B2 (ja) 2000-07-10
RU2195455C2 (ru) 2002-12-27
TW411332B (en) 2000-11-11
US5965579A (en) 1999-10-12
IL117860A0 (en) 1996-08-04
JPH11504624A (ja) 1999-04-27
US6172239B1 (en) 2001-01-09
NO310071B1 (no) 2001-05-14
MY114424A (en) 2002-10-31
HUP9801435A3 (en) 1998-12-28
FR2732967B1 (fr) 1997-07-04

Similar Documents

Publication Publication Date Title
SK136797A3 (en) Substituted 1-phenylpyrazole-3-carboxamides acting on neurotensin receptors, a method for the preparation of them, and pharmaceutical compositions containing them
KR100814599B1 (ko) 신경퇴행성 장애 치료용 이미다졸 화합물
AU2017277003B2 (en) Phenyl propanamide derivative, and manufacturing method and pharmaceutical application thereof
PT91623B (pt) Processo para a preparacao de agentes anti-hipertensivos de glutaramida substituida com cicloalquilo
SK42693A3 (en) Indoline derivatives with amidic group
JP2019503385A (ja) Ｒｏｒ−ガンマのモジュレータとしてのベンズイミダゾール誘導体
DE69507293T2 (de) Benzamid-derivate als vasopressin-antagonisten
US5585497A (en) Substituted 1-naphthyl-3-pyrazolecarboxamides which are active on neurotensin
TW201211029A (en) Substituted cyclic carboxamide and urea derivatives as ligands of the vanilloid receptor
DE69226157T2 (de) Antiallergische, entzündungshemmende und anti-PAF Pyridazinverbindungen
PL224990B1 (pl) Niepeptydowi antagoniści bradykininy o charakterze zasadowym i ich zastosowanie, kompozycje farmaceutyczne oraz związki pośrednie
CN108191835A (zh) 一类新型的含吡咯环和吲哚啉结构rip1激酶抑制剂及其用途
UA128087C2 (uk) Заміщені алкініленові сполуки як протипухлинні засоби
EP2989105B1 (en) Pyrazino[1,2-a]indole compounds, their preparation and use in medicaments
TW202345818A (zh) 抗病毒雜環化合物
CN108503584A (zh) 一种1,2,3,4-四氢喹啉磺酰胺类化合物及其应用
WO2023279995A1 (zh) 一类抗膀胱癌的季胺盐化合物及其应用
TW200524863A (en) Novel N-substituted indolyl-3-glyoxylamides, their use as medicaments and process for their preparation
JP2023534713A (ja) バソプレシン受容体ｖ１ａアンタゴニストとしてのシクロヘキシル置換トリアゾール
JPH107658A (ja) スルホニルウレイドピラゾール誘導体
JPH08506572A (ja) ピラゾール誘導体およびその医薬組成物