SK11232001A3 - Použitie hematopoietickej kmeňovej bunky - Google Patents
Použitie hematopoietickej kmeňovej bunky Download PDFInfo
- Publication number
- SK11232001A3 SK11232001A3 SK1123-2001A SK11232001A SK11232001A3 SK 11232001 A3 SK11232001 A3 SK 11232001A3 SK 11232001 A SK11232001 A SK 11232001A SK 11232001 A3 SK11232001 A3 SK 11232001A3
- Authority
- SK
- Slovakia
- Prior art keywords
- cells
- disease
- transplantation
- treatment
- hematopoietic stem
- Prior art date
Links
- 238000002054 transplantation Methods 0.000 title claims abstract description 21
- 210000004524 haematopoietic cell Anatomy 0.000 title 1
- 210000004556 brain Anatomy 0.000 claims abstract description 17
- 201000010099 disease Diseases 0.000 claims abstract description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 10
- 210000000130 stem cell Anatomy 0.000 claims abstract description 8
- 208000018737 Parkinson disease Diseases 0.000 claims abstract description 6
- 208000024827 Alzheimer disease Diseases 0.000 claims abstract description 4
- 230000008439 repair process Effects 0.000 claims abstract description 4
- 210000004027 cell Anatomy 0.000 claims description 62
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims description 18
- 230000007812 deficiency Effects 0.000 claims description 10
- 230000001953 sensory effect Effects 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 7
- 230000003137 locomotive effect Effects 0.000 claims description 5
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- 108700020796 Oncogene Proteins 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 208000006264 Korsakoff syndrome Diseases 0.000 claims description 2
- 239000000427 antigen Substances 0.000 claims description 2
- 108091007433 antigens Proteins 0.000 claims description 2
- 102000036639 antigens Human genes 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- 210000000133 brain stem Anatomy 0.000 claims 1
- 230000003394 haemopoietic effect Effects 0.000 abstract 2
- 230000006378 damage Effects 0.000 description 14
- 208000029028 brain injury Diseases 0.000 description 4
- 210000005260 human cell Anatomy 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 210000001178 neural stem cell Anatomy 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 206010012289 Dementia Diseases 0.000 description 2
- 208000010496 Heart Arrest Diseases 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000000601 blood cell Anatomy 0.000 description 2
- 210000001185 bone marrow Anatomy 0.000 description 2
- 230000006931 brain damage Effects 0.000 description 2
- 231100000874 brain damage Toxicity 0.000 description 2
- 230000006735 deficit Effects 0.000 description 2
- 230000004064 dysfunction Effects 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 230000002068 genetic effect Effects 0.000 description 2
- 239000003102 growth factor Substances 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 208000028867 ischemia Diseases 0.000 description 2
- 230000000302 ischemic effect Effects 0.000 description 2
- 210000001577 neostriatum Anatomy 0.000 description 2
- 230000004770 neurodegeneration Effects 0.000 description 2
- 208000015122 neurodegenerative disease Diseases 0.000 description 2
- 230000000644 propagated effect Effects 0.000 description 2
- 208000000044 Amnesia Diseases 0.000 description 1
- 208000031091 Amnestic disease Diseases 0.000 description 1
- 201000011240 Frontotemporal dementia Diseases 0.000 description 1
- 208000031220 Hemophilia Diseases 0.000 description 1
- 208000009292 Hemophilia A Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 206010061216 Infarction Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000000609 Pick Disease of the Brain Diseases 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 230000006986 amnesia Effects 0.000 description 1
- 210000004102 animal cell Anatomy 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 210000001130 astrocyte Anatomy 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000003542 behavioural effect Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 230000007177 brain activity Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000011712 cell development Effects 0.000 description 1
- 230000006727 cell loss Effects 0.000 description 1
- 206010008129 cerebral palsy Diseases 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 210000004351 coronary vessel Anatomy 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 230000009189 diving Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000004077 genetic alteration Effects 0.000 description 1
- 231100000118 genetic alteration Toxicity 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 208000018706 hematopoietic system disease Diseases 0.000 description 1
- 230000000971 hippocampal effect Effects 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- 230000007574 infarction Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000000520 microinjection Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000000066 myeloid cell Anatomy 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 210000003061 neural cell Anatomy 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000009984 peri-natal effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 208000007056 sickle cell anemia Diseases 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 230000009182 swimming Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 230000002463 transducing effect Effects 0.000 description 1
- 230000005740 tumor formation Effects 0.000 description 1
- 230000002861 ventricular Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/04—Immortalised cells
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Wood Science & Technology (AREA)
- Developmental Biology & Embryology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Hospice & Palliative Care (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9904281.4A GB9904281D0 (en) | 1999-02-24 | 1999-02-24 | Transplantation |
| PCT/GB2000/000636 WO2000050568A2 (en) | 1999-02-24 | 2000-02-23 | Transplantation of haematopoietic cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK11232001A3 true SK11232001A3 (sk) | 2002-01-07 |
Family
ID=10848438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1123-2001A SK11232001A3 (sk) | 1999-02-24 | 2000-02-23 | Použitie hematopoietickej kmeňovej bunky |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1161521B1 (de) |
| JP (1) | JP4716575B2 (de) |
| KR (1) | KR20020000216A (de) |
| CN (1) | CN1636053A (de) |
| AT (1) | ATE237680T1 (de) |
| AU (1) | AU762763B2 (de) |
| CA (1) | CA2361401A1 (de) |
| CZ (1) | CZ20012651A3 (de) |
| DE (1) | DE60002185T2 (de) |
| DK (1) | DK1161521T3 (de) |
| ES (1) | ES2193938T3 (de) |
| GB (1) | GB9904281D0 (de) |
| HK (1) | HK1041284B (de) |
| HU (1) | HUP0105168A3 (de) |
| NO (1) | NO20014091L (de) |
| PL (1) | PL350297A1 (de) |
| PT (1) | PT1161521E (de) |
| RU (1) | RU2216336C2 (de) |
| SK (1) | SK11232001A3 (de) |
| WO (1) | WO2000050568A2 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9518606D0 (en) | 1995-09-12 | 1995-11-15 | Inst Of Psychiatry | Neural transplantation |
| JP2002544234A (ja) * | 1999-05-14 | 2002-12-24 | ヘンリー フォード ヘルス システム | 発作の処置のための骨髄移植 |
| US8017112B2 (en) | 1999-05-14 | 2011-09-13 | Henry Ford Health System | Transplantation of bone marrow stromal cells for treatment of neurodegenerative diseases |
| AU2003209259A1 (en) * | 2002-01-14 | 2003-07-30 | The Board Of Trustees Of The University Of Illinois | Novel mammalian multipotent stem cells and compositions, methods of preparation and methods of administration thereof |
| AU2003280824A1 (en) * | 2002-11-15 | 2004-06-15 | Fumihiko Ishikawa | Method of organ regeneration |
| DK1645626T3 (da) | 2004-09-30 | 2008-01-21 | Reneuron Ltd | Cellelinie |
| RU2283119C1 (ru) * | 2005-03-29 | 2006-09-10 | Андрей Степанович БРЮХОВЕЦКИЙ | Препарат аутологичных гемопоэтических стволовых клеток, способ его получения, криоконсервации и использования для лечения травматической болезни центральной нервной системы |
| US7569545B2 (en) * | 2005-05-20 | 2009-08-04 | Academia Sinica | Methods of increasing neurotrophic factor expression |
| EP2423303A1 (de) * | 2006-03-24 | 2012-02-29 | Children's Medical Center Corporation | Verfahren zur Modulierung des Wachstums blutbildender Stammzellen |
| RU2480213C2 (ru) | 2006-10-20 | 2013-04-27 | Чилдрен'З Медикал Сентер Корпорейшн | Способ стимуляции регенерации тканей |
| EP2326330B1 (de) | 2008-09-16 | 2015-01-07 | University Of Central Florida Research Foundation, Inc. | Zusammensetzungen zur behandlung oder verzögerung des beginns von haarverlust |
| WO2010091052A2 (en) | 2009-02-03 | 2010-08-12 | Children's Medical Center Corporation | Methods for enhancing hematopoietic stem/progenitor cell engraftment |
| WO2010096264A2 (en) | 2009-02-03 | 2010-08-26 | Children's Medical Center Corporation | Methods for enhancing hematopoietic stem/progenitor cell engraftment |
| GB0902034D0 (en) | 2009-02-06 | 2009-03-11 | Reneuron Ltd | Method |
| ES2672693T3 (es) * | 2011-04-20 | 2018-06-15 | The Regents Of The University Of California | Método para el acondicionamiento y quimioselección combinadas en un único ciclo |
| ES2682255T3 (es) | 2011-12-02 | 2018-09-19 | Fate Therapeutics, Inc. | Métodos mejorados de tratamiento de isquemia |
| JP6220791B2 (ja) | 2011-12-02 | 2017-10-25 | フェイト セラピューティクス，インコーポレイテッド | 増強された幹細胞組成物 |
| WO2014150602A1 (en) | 2013-03-15 | 2014-09-25 | Fate Therapeutics, Inc. | Cell potency assay for therapeutic potential |
| RU2647429C1 (ru) * | 2017-02-06 | 2018-03-15 | Федеральное государственное автономное образовательное учреждение высшего образования "Дальневосточный федеральный университет" (ДВФУ) | Биомедицинский клеточный препарат |
| RU2720002C1 (ru) * | 2018-12-28 | 2020-04-23 | Андрей Степанович БРЮХОВЕЦКИЙ | Биомедицинский клеточный продукт для лечения нервных болезней и психических расстройств, способ его получения и его применение |
| CN114934072B (zh) * | 2022-05-18 | 2023-10-20 | 华中科技大学同济医学院附属协和医院 | 一种人心脏瓣膜间质细胞系的永生化构建方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5399493A (en) * | 1989-06-15 | 1995-03-21 | The Regents Of The University Of Michigan | Methods and compositions for the optimization of human hematopoietic progenitor cell cultures |
| US5612211A (en) * | 1990-06-08 | 1997-03-18 | New York University | Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors |
| KR950700403A (ko) * | 1992-03-04 | 1995-01-16 | 죤 제이. 쉬바르츠 | 조혈 간세포의 배양 및 그것의 유전공학(culturing of hematopoietic stem cells and their genetic engineering) |
| CA2225601C (en) * | 1995-06-27 | 2003-10-14 | Boehringer Ingelheim Kg | New stable pharmaceutical preparation for producing propellant-free aerosols |
| GB9518606D0 (en) * | 1995-09-12 | 1995-11-15 | Inst Of Psychiatry | Neural transplantation |
| WO1998007841A1 (en) * | 1996-08-19 | 1998-02-26 | University Of Massachusetts | Embryonic or stem-like cell lines produced by cross species nuclear transplantation |
-
1999
- 1999-02-24 GB GBGB9904281.4A patent/GB9904281D0/en not_active Ceased
-
2000
- 2000-02-23 CA CA002361401A patent/CA2361401A1/en not_active Abandoned
- 2000-02-23 PT PT00905194T patent/PT1161521E/pt unknown
- 2000-02-23 EP EP00905194A patent/EP1161521B1/de not_active Expired - Lifetime
- 2000-02-23 AT AT00905194T patent/ATE237680T1/de not_active IP Right Cessation
- 2000-02-23 DE DE60002185T patent/DE60002185T2/de not_active Expired - Lifetime
- 2000-02-23 PL PL00350297A patent/PL350297A1/xx not_active Application Discontinuation
- 2000-02-23 RU RU2001125914/15A patent/RU2216336C2/ru not_active IP Right Cessation
- 2000-02-23 WO PCT/GB2000/000636 patent/WO2000050568A2/en not_active Application Discontinuation
- 2000-02-23 HU HU0105168A patent/HUP0105168A3/hu unknown
- 2000-02-23 CZ CZ20012651A patent/CZ20012651A3/cs unknown
- 2000-02-23 DK DK00905194T patent/DK1161521T3/da active
- 2000-02-23 KR KR1020017010773A patent/KR20020000216A/ko not_active Application Discontinuation
- 2000-02-23 CN CNA008041865A patent/CN1636053A/zh active Pending
- 2000-02-23 SK SK1123-2001A patent/SK11232001A3/sk unknown
- 2000-02-23 ES ES00905194T patent/ES2193938T3/es not_active Expired - Lifetime
- 2000-02-23 AU AU26821/00A patent/AU762763B2/en not_active Ceased
- 2000-02-23 JP JP2000601132A patent/JP4716575B2/ja not_active Expired - Fee Related
-
2001
- 2001-08-23 NO NO20014091A patent/NO20014091L/no not_active Application Discontinuation
-
2002
- 2002-02-15 HK HK02101109.4A patent/HK1041284B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HK1041284B (zh) | 2003-10-03 |
| ES2193938T3 (es) | 2003-11-16 |
| NO20014091D0 (no) | 2001-08-23 |
| JP4716575B2 (ja) | 2011-07-06 |
| AU2682100A (en) | 2000-09-14 |
| GB9904281D0 (en) | 1999-04-21 |
| NO20014091L (no) | 2001-08-23 |
| CN1636053A (zh) | 2005-07-06 |
| KR20020000216A (ko) | 2002-01-05 |
| PL350297A1 (en) | 2002-12-02 |
| ATE237680T1 (de) | 2003-05-15 |
| EP1161521B1 (de) | 2003-04-16 |
| AU762763B2 (en) | 2003-07-03 |
| JP2002537406A (ja) | 2002-11-05 |
| HK1041284A1 (en) | 2002-07-05 |
| HUP0105168A3 (en) | 2003-12-29 |
| DK1161521T3 (da) | 2003-06-16 |
| WO2000050568A2 (en) | 2000-08-31 |
| EP1161521A2 (de) | 2001-12-12 |
| CZ20012651A3 (cs) | 2002-01-16 |
| DE60002185T2 (de) | 2003-12-18 |
| RU2216336C2 (ru) | 2003-11-20 |
| PT1161521E (pt) | 2003-08-29 |
| CA2361401A1 (en) | 2000-08-31 |
| DE60002185D1 (de) | 2003-05-22 |
| HUP0105168A2 (hu) | 2002-05-29 |
| WO2000050568A3 (en) | 2000-12-07 |
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