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DK1645626T3 - Cellelinie - Google Patents

Cellelinie

Info

Publication number
DK1645626T3
DK1645626T3 DK05255932T DK05255932T DK1645626T3 DK 1645626 T3 DK1645626 T3 DK 1645626T3 DK 05255932 T DK05255932 T DK 05255932T DK 05255932 T DK05255932 T DK 05255932T DK 1645626 T3 DK1645626 T3 DK 1645626T3
Authority
DK
Denmark
Prior art keywords
cell line
cell lines
relates
present
accession nos
Prior art date
Application number
DK05255932T
Other languages
English (en)
Inventor
John Sinden
Kenneth Pollack
Paul Stroemer
Original Assignee
Reneuron Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0421753A external-priority patent/GB0421753D0/en
Priority claimed from GB0425767A external-priority patent/GB0425767D0/en
Priority claimed from GB0427830A external-priority patent/GB0427830D0/en
Application filed by Reneuron Ltd filed Critical Reneuron Ltd
Application granted granted Critical
Publication of DK1645626T3 publication Critical patent/DK1645626T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0618Cells of the nervous system
    • C12N5/0623Stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/05Inorganic components
    • C12N2500/10Metals; Metal chelators
    • C12N2500/20Transition metals
    • C12N2500/24Iron; Fe chelators; Transferrin
    • C12N2500/25Insulin-transferrin; Insulin-transferrin-selenium
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • C12N2500/46Amines, e.g. putrescine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/11Epidermal growth factor [EGF]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/115Basic fibroblast growth factor (bFGF, FGF-2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30Hormones
    • C12N2501/38Hormones with nuclear receptors
    • C12N2501/39Steroid hormones
    • C12N2501/392Sexual steroids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00Genetically modified cells
    • C12N2510/04Immortalised cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Semiconductor Memories (AREA)
  • Semiconductor Lasers (AREA)
  • Internal Circuitry In Semiconductor Integrated Circuit Devices (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK05255932T 2004-09-30 2005-09-23 Cellelinie DK1645626T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0421753A GB0421753D0 (en) 2004-09-30 2004-09-30 Cell line
GB0425767A GB0425767D0 (en) 2004-11-23 2004-11-23 Cell line
GB0427830A GB0427830D0 (en) 2004-12-20 2004-12-20 Cell line

Publications (1)

Publication Number Publication Date
DK1645626T3 true DK1645626T3 (da) 2008-01-21

Family

ID=35744948

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05255932T DK1645626T3 (da) 2004-09-30 2005-09-23 Cellelinie

Country Status (9)

Country Link
US (3) US7416888B2 (da)
EP (1) EP1645626B1 (da)
JP (1) JP5036156B2 (da)
AT (1) ATE373081T1 (da)
AU (1) AU2005218041B2 (da)
CA (1) CA2521421C (da)
DE (1) DE602005002430T2 (da)
DK (1) DK1645626T3 (da)
ES (1) ES2294650T3 (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9518606D0 (en) * 1995-09-12 1995-11-15 Inst Of Psychiatry Neural transplantation
ES2294650T3 (es) * 2004-09-30 2008-04-01 Reneuron Limited Linea celular.
GB0822246D0 (en) 2008-12-05 2009-01-14 Reneuron Ltd Composition
GB0902034D0 (en) 2009-02-06 2009-03-11 Reneuron Ltd Method
WO2011015573A1 (en) 2009-08-03 2011-02-10 Galapagos Nv Molecular targets and compounds, and methods to identify the same, useful in the treatment of neurodegenerative diseases
GB201011589D0 (en) 2010-07-09 2010-08-25 Reneuron Ltd Therapeutic cells
GB201302468D0 (en) 2013-02-12 2013-03-27 Reneuron Ltd Stem cell product
CA2868506C (en) * 2012-04-03 2023-10-24 Reneuron Limited Stem cell microparticles
WO2014013258A1 (en) 2012-07-19 2014-01-23 Reneuron Limited Stem cell microparticles
ES2927175T3 (es) 2013-02-12 2022-11-03 Reneuron Ltd Método de producción de micropartículas
GB201317887D0 (en) 2013-10-09 2013-11-20 Reneuron Ltd Product
GB201317889D0 (en) 2013-10-09 2013-11-20 Reneuron Ltd Product and use
US20200108100A1 (en) * 2018-10-08 2020-04-09 Reneuron Limited Neural stem cell therapy for stroke
KR20210102195A (ko) 2018-10-12 2021-08-19 레뉴런 리미티드 조건부 불멸화를 위한 제어가능한 트랜스진을 포함하는 유도된 만능 세포
GB201911464D0 (en) 2019-08-09 2019-09-25 Reneuron Ltd Genetic modification site
GB201919021D0 (en) 2019-12-20 2020-02-05 Reneuron Ltd Nucleic acid constructs for delivering polynucleotides into exosomes
GB202005494D0 (en) 2020-04-15 2020-05-27 Reneuron Ltd Induced pluripotent cell comprising a contollable transgene for conditional immortalisation
GB202114441D0 (en) 2021-10-08 2021-11-24 Reneuron Ltd Proteins and extracellular vesicles

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ226750A (en) 1987-10-29 1990-09-26 Amrad Corp Ltd Immortalisation of neural precursor cells by introducing a retrovirus vector containing a myc-oncogene
US5270191A (en) 1988-04-12 1993-12-14 Massachusetts Institute Of Technology Method for manipulation of the cell types of eukaryotes
DE68907220T2 (de) 1988-04-12 1994-01-27 Massachusetts Inst Technology Verfahren zur manipulation des zelltyps von eukaryonten.
US5399493A (en) 1989-06-15 1995-03-21 The Regents Of The University Of Michigan Methods and compositions for the optimization of human hematopoietic progenitor cell cultures
WO1991009936A1 (en) 1989-12-26 1991-07-11 Hana Biologics, Inc. Proliferated neuron progenitor cell product and process
US5612211A (en) 1990-06-08 1997-03-18 New York University Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors
US5851832A (en) 1991-07-08 1998-12-22 Neurospheres, Ltd. In vitro growth and proliferation of multipotent neural stem cells and their progeny
DE69233061T3 (de) 1991-07-08 2008-07-10 Neurospheres Holding Ltd., Calgary Auf wachstumsfaktoren reagierende neurale vorläuferzellen, die in vitro vermehrt werden können.
EP0631618A4 (en) 1992-03-04 1995-09-27 Systemix Inc CULTIVATION OF HEMOPOETIC STEM CELLS AND THEIR GENETOLOGICAL PRODUCTION.
US5753491A (en) 1993-04-13 1998-05-19 Us Health Use of neuro-derived fetal cell lines for transplantation therapy
WO1994023754A1 (en) 1993-04-13 1994-10-27 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of neuro-derived fetal cell lines for transplantation therapy
ATE261492T1 (de) 1994-11-08 2004-03-15 Cellfactors Plc Methode zur herstellung einer menschlichen neuralen zelllinie
AU716811B2 (en) 1994-11-14 2000-03-09 Neurospheres Holdings Ltd Regulation of neural stem cell proliferation
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
GB9517263D0 (en) 1995-08-23 1995-10-25 Cancer Res Campaign Tech Expression systems
GB9518606D0 (en) 1995-09-12 1995-11-15 Inst Of Psychiatry Neural transplantation
US5588692A (en) 1995-10-11 1996-12-31 General Motors Corporation Push-out vehicle side door
EP0773287A1 (en) * 1995-11-07 1997-05-14 Bayer Ag Immortalised embryonic hyppocampal cells and their use
US5770414A (en) * 1996-02-20 1998-06-23 The Regents Of The University Of California Regulatable retrovirus system for genetic modification of cells
US7544511B2 (en) * 1996-09-25 2009-06-09 Neuralstem Biopharmaceuticals Ltd. Stable neural stem cell line methods
EP0934403A4 (en) 1996-08-19 2001-03-14 Univ Massachusetts ROWS OF EMBRYONIC OR STRAIN-LIKE CELLS PRODUCED BY CROSS NUCLEAR TRANSPLANTATION OF SPECIES
US20020123143A1 (en) 1997-08-22 2002-09-05 Jean Toma Multipotent stem cells from peripheral tissues and uses thereof
US5968829A (en) 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells
ES2246085T3 (es) 1998-05-07 2006-02-01 University Of South Florida Celulas de medula osea como fuente de neuronas util para reparar la medula espinal y el cerebro.
US5958767A (en) 1998-08-14 1999-09-28 The Children's Medical Center Corp. Engraftable human neural stem cells
GB9904281D0 (en) 1999-02-24 1999-04-21 Reneuron Ltd Transplantation
GB9907243D0 (en) 1999-03-29 1999-05-26 Reneuron Ltd Therapy
US6399384B1 (en) 1999-09-17 2002-06-04 Reneuron Limited Conditional immortalization of cells
US6465215B1 (en) 1999-12-14 2002-10-15 Reneuron Limited Identification of cells for transplantation
JP2003516141A (ja) * 1999-12-07 2003-05-13 モナシュ・ユニヴァーシティ 長期細胞培養組成物とそれから誘導される遺伝的に修飾された動物
AU2001243464B2 (en) 2000-03-09 2006-04-13 Saneron Ccel Therapeutics, Inc. Human cord blood as a source of neural tissue for repair of the brain and spinal cord
GB0005856D0 (en) * 2000-03-10 2000-05-03 Reneuron Ltd Genetic constructs
US7250294B2 (en) 2000-05-17 2007-07-31 Geron Corporation Screening small molecule drugs using neural cells differentiated from human embryonic stem cells
US7049072B2 (en) 2000-06-05 2006-05-23 University Of South Florida Gene expression analysis of pluri-differentiated mesenchymal progenitor cells and methods for diagnosing a leukemic disease state
WO2001094541A2 (en) 2000-06-05 2001-12-13 University Of South Florida Human mesenchymal progenitor cell
WO2003029432A2 (en) 2001-10-03 2003-04-10 University Of South Florida Human mesenchymal progenitor cell
GB0125773D0 (en) 2001-10-26 2001-12-19 Reneuron Ltd Constructs
US20040185429A1 (en) * 2002-12-09 2004-09-23 Judith Kelleher-Andersson Method for discovering neurogenic agents
ES2294650T3 (es) * 2004-09-30 2008-04-01 Reneuron Limited Linea celular.

Also Published As

Publication number Publication date
AU2005218041B2 (en) 2010-09-16
US20060067918A1 (en) 2006-03-30
DE602005002430D1 (de) 2007-10-25
JP5036156B2 (ja) 2012-09-26
ES2294650T3 (es) 2008-04-01
CA2521421A1 (en) 2006-03-30
DE602005002430T2 (de) 2008-06-19
ATE373081T1 (de) 2007-09-15
JP2006122045A (ja) 2006-05-18
EP1645626B1 (en) 2007-09-12
AU2005218041A1 (en) 2006-04-13
US7666672B2 (en) 2010-02-23
CA2521421C (en) 2013-08-06
US7419827B2 (en) 2008-09-02
US20060104959A1 (en) 2006-05-18
US20080118479A1 (en) 2008-05-22
US7416888B2 (en) 2008-08-26
EP1645626A1 (en) 2006-04-12

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