[go: up one dir, main page]

SK10492003A3 - Spôsob identifikácie, izolácie a produkcie antigénov špecifického patogénu - Google Patents

Spôsob identifikácie, izolácie a produkcie antigénov špecifického patogénu Download PDF

Info

Publication number
SK10492003A3
SK10492003A3 SK1049-2003A SK10492003A SK10492003A3 SK 10492003 A3 SK10492003 A3 SK 10492003A3 SK 10492003 A SK10492003 A SK 10492003A SK 10492003 A3 SK10492003 A3 SK 10492003A3
Authority
SK
Slovakia
Prior art keywords
seq
amino acids
pct
antigens
reactive
Prior art date
Application number
SK1049-2003A
Other languages
English (en)
Slovak (sk)
Inventor
Andreas Meinke
Eszter Nagy
Ahsen Uwe Von
Christoph Klade
Tamas Henics
Wolfgang Zauner
Duc Bui Minh
Oresta Vytvytska
Hildegard Etz
Agnieszka Dryla
Thomas Weichhart
Martin Hafner
Brigitte Tempelmaier
Claire M. Fraser
Steven Gill
Original Assignee
Intercell Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intercell Ag filed Critical Intercell Ag
Publication of SK10492003A3 publication Critical patent/SK10492003A3/sk

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/02Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1271Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1037Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1041Ribosome/Polysome display, e.g. SPERT, ARM
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Analytical Chemistry (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
SK1049-2003A 2001-01-26 2002-01-21 Spôsob identifikácie, izolácie a produkcie antigénov špecifického patogénu SK10492003A3 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0013001A AT410798B (de) 2001-01-26 2001-01-26 Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen
PCT/EP2002/000546 WO2002059148A2 (en) 2001-01-26 2002-01-21 A method for identification, isolation and production of antigens to a specific pathogen

Publications (1)

Publication Number Publication Date
SK10492003A3 true SK10492003A3 (sk) 2004-07-07

Family

ID=3636418

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1049-2003A SK10492003A3 (sk) 2001-01-26 2002-01-21 Spôsob identifikácie, izolácie a produkcie antigénov špecifického patogénu

Country Status (24)

Country Link
US (4) US7968297B2 (de)
EP (6) EP1355930B1 (de)
JP (2) JP2004531476A (de)
KR (4) KR20080107477A (de)
CN (2) CN1649894A (de)
AT (2) AT410798B (de)
AU (3) AU2002247641B8 (de)
BR (1) BR0207067A (de)
CA (2) CA2792244A1 (de)
CZ (1) CZ20032201A3 (de)
DE (1) DE60207194T2 (de)
DK (1) DK1355930T3 (de)
ES (1) ES2252438T3 (de)
HU (1) HUP0402048A3 (de)
IL (4) IL157082A0 (de)
IS (1) IS6895A (de)
MX (1) MXPA03006702A (de)
NO (1) NO20033364L (de)
NZ (4) NZ527440A (de)
PL (2) PL214482B1 (de)
RU (1) RU2289817C2 (de)
SK (1) SK10492003A3 (de)
WO (1) WO2002059148A2 (de)
ZA (1) ZA200305764B (de)

Families Citing this family (133)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1353689T3 (da) 2001-01-03 2006-07-31 Epitopix Llc Immuniseringspræparater og anvendelse deraf
AT410798B (de) 2001-01-26 2003-07-25 Cistem Biotechnologies Gmbh Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen
GB0107661D0 (en) * 2001-03-27 2001-05-16 Chiron Spa Staphylococcus aureus
EP2320233A1 (de) 2001-06-15 2011-05-11 Inhibitex, Inc. Kreuzreaktive monoklonale und polyklonale Antikörper, die Oberflächenprotein aus Koagulasenegativen Staphylococci und Staphylococcus aureus erkennen
GB0200865D0 (en) * 2002-01-16 2002-03-06 Univ Bristol Method
GB2387600A (en) * 2002-04-19 2003-10-22 Pantherix Ltd Pantothenate kinase
WO2004030699A1 (en) * 2002-10-03 2004-04-15 Intercell Ag Use of molecules which interact with the haptoglobin receptor ligand binding
EP1601770B1 (de) 2003-03-04 2009-09-02 Intercell AG Streptococcus pyogenes antigene
US7628994B2 (en) 2003-03-31 2009-12-08 Intercell Ag S. epidermidis antigens
CN1774447B (zh) 2003-04-15 2011-04-06 英特塞尔股份公司 肺炎链球菌抗原
WO2004094467A2 (en) * 2003-04-22 2004-11-04 Intercell Ag H. pylori antigens
AU2004235952A1 (en) 2003-05-07 2004-11-18 Intercell Ag Streptococcus agalactiae antigens I + II
EP2327720A1 (de) 2003-05-30 2011-06-01 Intercell AG Enterokokken-Antigene
RU2257217C2 (ru) * 2003-07-08 2005-07-27 Государственное научное учреждение Институт экспериментальной ветеринарии Сибири и Дальнего Востока Сибирского отделения Россельхозакадемии (ГНУ ИЭВСиДВ СО РАСХН) Гипериммунный тканевой препарат
US20060188515A1 (en) * 2003-07-24 2006-08-24 Anderson Annaliesa S Polypeptides for inducing a protective immune response against staphylococcus aureus
SI1651166T1 (sl) * 2003-07-24 2010-06-30 Merck Sharp & Dohme Polipeptidi za induciranje zaščitnega imunskegaodgovora proti stafilokoknem eureusu
WO2005028665A2 (en) 2003-09-19 2005-03-31 Epitopix, Llc Campylobacter polypeptides and methods of use
EP1725575B1 (de) * 2004-02-18 2012-11-28 Merck Sharp & Dohme Corp. Polypeptide zur induktion einer protektiven immunantwort gegen staphylococcus aureus
US20070172498A1 (en) * 2004-02-27 2007-07-26 Anderson Annaliesa S Polypeptides for inducing a protective immune response against staphyloococcus aureus
JP2005278537A (ja) * 2004-03-30 2005-10-13 Dai Ichi Seiyaku Co Ltd 新規ポリペプチド
JP2008508855A (ja) * 2004-04-27 2008-03-27 インターツェル・アクチェンゲゼルシャフト Td抗原
US7842479B2 (en) 2004-05-21 2010-11-30 The Board Of Regents Of The University Of Nebraska Methods for altering acetic acid production and enhancing cell death in bacteria
CA2565330A1 (en) * 2004-05-25 2005-12-08 Merck & Co., Inc. Polypeptides for inducing a protective immune response against staphylococcus aureus
EP1781326A4 (de) * 2004-06-04 2009-01-14 Pharmexa Inc Induktion einer immunantwort gegen streptokokkenpneumonie-polysacchariden
FR2871159A1 (fr) * 2004-06-08 2005-12-09 Abag Sa Nouvelles proteines permettant, notamment, la mise en evidence in vitro et la prevention des infections a staphylocoques a coagulase negative
FR2871237B1 (fr) * 2004-06-08 2011-03-11 Abag Nouveaux polypeptides pour la mise en evidence in vitro et la prevention des infections staphylococciques sur protheses articulaires et autres materiels etrangers implantes
WO2007018482A2 (en) * 2004-07-06 2007-02-15 Merck & Co., Inc. Polypeptides for inducing a protective immune response against staphylococcus aureus
WO2007001361A2 (en) * 2004-09-17 2007-01-04 Merck & Co., Inc. Polypeptides for inducing a protective immune response against staphylococcus aureus
EP2181714A3 (de) 2004-09-22 2010-06-23 GlaxoSmithKline Biologicals S.A. Immunogene Zusammensetzung zur Verwendung zur Impfung gegen Staphylokokken
EP2340848A3 (de) 2004-10-21 2011-09-14 Wyeth LLC Immunogene Zusammensetzungen von Staphylococcus epidermidis Polypeptide und Polynucleotide Antigenen
AU2005298742B2 (en) * 2004-10-29 2010-08-12 Intercell Ag HCV vaccines for chronic HCV patients
CN101432017B (zh) 2005-01-21 2011-12-21 默沙东公司 用于诱导针对金黄色葡萄球菌的保护性免疫应答的多肽
EP2431382A1 (de) 2005-01-21 2012-03-21 Epitopix, LLC Yersinia ssp., Polypeptide und Verwendungsverfahren
NZ613923A (en) 2005-02-14 2015-02-27 Epitopix Llc Antibody compositions that bind polypeptides from staphylococcus aureus
JP2008534970A (ja) * 2005-04-04 2008-08-28 ヴィヴェンティア バイオテック インコーポレーティッド 抗原の同定のための方法および系
WO2006121664A2 (en) * 2005-05-05 2006-11-16 Merck & Co., Inc. Polypeptides for inducing a protective immune response against staphylococcus aureus
WO2006124644A2 (en) * 2005-05-12 2006-11-23 Board Of Regents, The University Of Texas System Protein and antibody profiling using small molecule microarrays
WO2007007352A2 (en) * 2005-07-14 2007-01-18 Bharat Biotech International Limited A vaccine for staphylococcal infections
CA2637598A1 (en) * 2006-01-18 2007-02-14 University Of Chicago Compositions and methods related to staphylococcal bacterium proteins
SG170090A1 (en) 2006-03-30 2011-04-29 Glaxosmithkline Biolog Sa Immunogenic composition
GB0610776D0 (en) * 2006-05-31 2006-07-12 Univ Bath Novel applications for staphylococcus aureus Sbi protein
CN101516905A (zh) * 2006-09-15 2009-08-26 英特塞尔股份公司 疏螺旋体属抗原
US20080102067A1 (en) * 2006-10-25 2008-05-01 Cook Mark E Immunogenic composition
EP1923069A1 (de) 2006-11-20 2008-05-21 Intercell AG Schutzpeptide gegen S. pneumoniae und diesbezügliche Zusammensetzungen, Verfahren und Verwendungen
EP1935984A1 (de) * 2006-12-20 2008-06-25 Unilever N.V. Screening-Verfahren zur Identifizierung eines Konservierungsmittels
WO2008140632A2 (en) 2007-01-24 2008-11-20 Merck & Co., Inc. Polypeptides for inducing a protective immune response against staphylococcus epidermidis
WO2008115415A2 (en) * 2007-03-19 2008-09-25 Merck & Co., Inc Polypeptides for inducing a protective immune response against staphylococcus epidermidis
CN101883782A (zh) * 2007-06-18 2010-11-10 英特塞尔股份公司 衣原体抗原
US9181329B2 (en) 2007-08-31 2015-11-10 The University Of Chicago Methods and compositions related to immunizing against Staphylococcal lung diseases and conditions
KR101661946B1 (ko) 2007-08-31 2016-10-05 유니버시티 오브 시카고 스타필로코커스 폐 질환 및 상태에 대한 면역화와 관련된 방법 및 조성물
CN101827932B (zh) * 2007-10-18 2013-03-13 荷兰联合利华有限公司 制备发泡剂的方法
CN101458255B (zh) * 2007-12-14 2013-03-06 武汉大学 丙型肝炎病毒包膜抗原夹心法试剂盒及检测方法
US20090196852A1 (en) * 2008-02-04 2009-08-06 Watkinson D Tobin Compositions and methods for diagnosing and treating immune disorders
CA2716706C (en) 2008-03-03 2014-02-18 Irm Llc Compounds and compositions as tlr activity modulators
JP2011514167A (ja) 2008-03-17 2011-05-06 インターセル アーゲー 肺炎連鎖球菌(S.pneumoniae)に対して保護的なペプチドならびにそれに関連する組成物、方法、および使用
WO2009158682A2 (en) * 2008-06-27 2009-12-30 Watkinson D Tobin Compositions and methods for diagnosing and treating pathogenic disorders
US20100015171A1 (en) * 2008-07-15 2010-01-21 Statens Serum Institute Vaccines comprising tb 10.4
WO2010014304A1 (en) 2008-07-29 2010-02-04 University Of Chicago Compositions and methods related to staphylococcal bacterium proteins
US8318180B2 (en) * 2008-09-30 2012-11-27 University Of Maryland, Baltimore Protective vaccine against Staphylococcus aureus biofilms comprising cell wall-associated immunogens
CA2739581A1 (en) * 2008-10-06 2010-04-15 University Of Chicago Compositions and methods related to bacterial eap, emp, and/or adsa proteins
WO2010043520A1 (en) * 2008-10-16 2010-04-22 Unilever Plc Hydrophobin solution containing antifoam
WO2010062814A1 (en) 2008-11-26 2010-06-03 Merck Sharp & Dohme Corp. Polypeptides for inducing a protective immune response against staphylococcus aureus
US20110229508A1 (en) 2008-11-26 2011-09-22 Merck Sharp & Dohme Corp. Polypeptides for inducing a protective immune response against staphylococcus aureus
RU2371201C1 (ru) * 2008-12-15 2009-10-27 Гурий Петрович Ступаков Способ лечения хронических заболеваний
SG162687A1 (en) 2008-12-24 2010-07-29 Millipore Corp Caustic stable chromatography ligands
EP2424882A2 (de) 2009-02-05 2012-03-07 Intercell AG Gegen e.-faecalis schützende peptide, verfahren und anwendungen, die damit in zusammenhang stehen
BRPI1011856A2 (pt) 2009-03-23 2020-11-03 Epitopix, Llc polipeptídeos e composições de imunização contendo polipeptídeos gram-positivos e métodos de uso
SG174968A1 (en) * 2009-04-03 2011-11-28 Univ Chicago Compositions and methods related to protein a (spa) variants
CA2758490C (en) * 2009-04-14 2023-05-02 Novartis Ag Compositions for immunising against staphylococcus aureus
CA2704702C (en) * 2009-06-02 2018-06-12 Unilever Plc Aerated baked products
US9517263B2 (en) 2009-06-10 2016-12-13 Glaxosmithkline Biologicals Sa Benzonaphthyridine-containing vaccines
SG176837A1 (en) 2009-06-22 2012-01-30 Wyeth Llc Immunogenic compositions of staphylococcus aureus antigens
GB0913681D0 (en) 2009-08-05 2009-09-16 Glaxosmithkline Biolog Sa Immunogenic composition
GB0913680D0 (en) 2009-08-05 2009-09-16 Glaxosmithkline Biolog Sa Immunogenic composition
TWI445708B (zh) 2009-09-02 2014-07-21 Irm Llc 作為tlr活性調節劑之化合物及組合物
BR112012004806B8 (pt) 2009-09-02 2022-10-04 Novartis Ag composições imunogênicas que incluem moduladores da atividade de tlr, método para aumento da eficácia da referida composição e uso
WO2011057148A1 (en) 2009-11-05 2011-05-12 Irm Llc Compounds and compositions as tlr-7 activity modulators
CN102762206A (zh) 2009-12-15 2012-10-31 诺华有限公司 免疫增强化合物的均匀悬液及其用途
WO2011101465A1 (en) 2010-02-19 2011-08-25 Intercell Ag Ic31 nanoparticles
EA023725B1 (ru) 2010-03-23 2016-07-29 Новартис Аг Соединения (липопептиды на основе цистеина) и композиции в качестве агонистов tlr2, применяемые для лечения инфекционных, воспалительных, респираторных и других заболеваний
US8808699B2 (en) 2010-04-05 2014-08-19 The University Of Chicago Compositions and methods related to protein A (SpA) antibodies as an enhancer of immune response
CN103025352B (zh) * 2010-05-05 2017-07-11 纽约大学 金黄色葡萄球菌杀白细胞素及其治疗组合物和用途
SG186290A1 (en) 2010-07-02 2013-01-30 Univ Chicago Compositions and methods related to protein a (spa) variants
US9192661B2 (en) 2010-07-06 2015-11-24 Novartis Ag Delivery of self-replicating RNA using biodegradable polymer particles
EP2593133A4 (de) 2010-07-13 2014-11-26 Merck Sharp & Dohme Staphylococcus aureus-oberflächenprotein sa1789 und darauf basierender schutzimpfstoff
EP2614074A1 (de) 2010-09-09 2013-07-17 The University of Chicago Verfahren und zusammensetzungen mit schützenden staphylokokken-antigenen
EP2638058B1 (de) 2010-11-12 2017-01-11 Merck Sharp & Dohme Corp. Enolase-peptid-konjugat-impfstoffe gegen staphylococcus aureus
CN102558316B (zh) * 2010-12-30 2015-07-01 上海雅心生物技术有限公司 高稳定性的具抗体结合能力的重组蛋白a及其生产
US8945588B2 (en) * 2011-05-06 2015-02-03 The University Of Chicago Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides
EP2720754B1 (de) 2011-06-19 2016-10-19 New York University Leukotoxin e/d als neue entzündungshemmer und mikrobizide
NZ764564A (en) * 2011-06-19 2022-10-28 Univ New York Methods of treating and preventing staphylococcus aureus infections and associated conditions
WO2013066731A2 (en) 2011-10-31 2013-05-10 Merck Sharp & Dohme Corp. Protective vaccine based on staphylococcus aureus sa2451 protein
DK2817329T3 (en) 2012-02-20 2019-04-01 Swedish Orphan Biovitrum Ab Publ Polypeptides Binding to Human Complement Component C5.
HRP20201127T1 (hr) 2012-04-26 2020-11-27 University Of Chicago Antigeni stafilokokne koagulaze i metode primjene istih
WO2014011645A1 (en) 2012-07-10 2014-01-16 Merck Sharp & Dohme Corp. Protective vaccine based on staphylococcus aureus sa2493 protein
RU2526497C2 (ru) * 2012-10-31 2014-08-20 Государственное бюджетное образовательное учреждение высшего профессионального образования "Северо-Западный государственный медицинский университет им. И.И. Мечникова" Министерства здравоохарнения и социального развития Российской Федерации Способ определения генотипов золотистого стафилококка
HUE049012T2 (hu) * 2012-11-06 2020-09-28 Medimmune Llc Antitestek S. aureus felszíni determinánsok ellen
WO2014096333A1 (en) * 2012-12-20 2014-06-26 Morphosys Ag Anti-staphylococcal antibodies
CN103965336B (zh) * 2013-01-29 2016-08-10 苏州偲聚生物材料有限公司 多肽、包含该多肽的检测器件和检测试剂盒
ES2670863T3 (es) 2013-02-01 2018-06-01 Glaxosmithkline Biologicals Sa Administración intradérmica de composiciones inmunológicas que comprenden agonistas del receptor de tipo Toll
AU2014258109B2 (en) * 2013-04-25 2016-09-29 Abtlas Co., Ltd. Method for refining protein including self-cutting cassette and use thereof
JP6767865B2 (ja) * 2013-08-28 2020-10-14 スウェディッシュ・オーファン・バイオヴィトラム・アーベー(ペーウーベーエル) ヒト補体c5に結合する安定なポリペプチド
MY176200A (en) 2013-08-28 2020-07-24 Affibody Ab Binding polypeptides having a mutated scaffold
CN104558196A (zh) * 2013-10-15 2015-04-29 温州医科大学 基于HBcAg载体的沙眼衣原体主要外膜蛋白表位疫苗及其用途
RU2542396C1 (ru) * 2013-11-06 2015-02-20 Федеральное бюджетное учреждение науки "Московский научно-исследовательский институт эпидемиологии и микробиологии им. Г.Н. Габричевского" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека Способ и набор для ускоренной лабораторной диагностики коклюшной инфекции
EP4227685A3 (de) * 2013-12-03 2024-02-28 Evaxion Biotech A/S Proteine und nukleinsäuren für impfstoffe gegen staphylococcus aureus
CN103694323B (zh) * 2013-12-09 2017-01-18 成都欧林生物科技股份有限公司 金黄色葡萄球菌MntC重组蛋白及其制备方法和应用
US10100093B2 (en) 2013-12-31 2018-10-16 Epitopix Llc Polypeptides and immunizing compositions containing Burkholderia polypeptides and methods of use
CN113694191A (zh) * 2014-06-30 2021-11-26 默多克儿童研究所 螺杆菌治疗剂
CN104569386B (zh) * 2014-12-10 2016-05-11 中国水产科学研究院淡水渔业研究中心 一种罗非鱼源无乳链球菌elisa快速检测试剂盒及其检测方法
MX376535B (es) * 2014-12-17 2025-03-07 Hoffmann La Roche Reacción enzimática en un solo recipiente para conjugación de polipéptido doble en un solo paso usando sortasa.
US10781246B2 (en) 2015-06-05 2020-09-22 New York University Compositions and methods for anti-staphylococcal biologic agents
EP3353310B1 (de) 2015-09-25 2020-04-29 H. Hoffnabb-La Roche Ag Verfahren zur herstellung von thioestern unter verwendung einer sortase a
CN108026560A (zh) 2015-09-25 2018-05-11 豪夫迈·罗氏有限公司 在低共熔溶剂中使用分选酶的转酰胺反应
JP6998862B2 (ja) 2015-09-25 2022-02-04 エフ.ホフマン-ラ ロシュ アーゲー 可溶性ソルターゼa
SG11201804402WA (en) 2015-11-27 2018-06-28 Univ Masarykova Thermostable fgf2 polypeptide, use thereof
US10166280B2 (en) 2016-06-08 2019-01-01 Epitopix, Llc Polypeptides and immunizing compositions containing Bacillus polypeptides and methods of use
US10738338B2 (en) 2016-10-18 2020-08-11 The Research Foundation for the State University Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate
US10504742B2 (en) * 2017-05-31 2019-12-10 Asm Ip Holding B.V. Method of atomic layer etching using hydrogen plasma
WO2018237010A2 (en) * 2017-06-20 2018-12-27 The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Vaccine compositions and methods of using the same
EP4410802A3 (de) 2018-02-12 2024-10-30 Inimmune Corporation Toll-like-rezeptorliganden
US10905738B2 (en) * 2018-07-05 2021-02-02 Biozeus Desenvolvimento De Produtos Biofarmacêuticos Synthetic peptides, prodrugs, pharmaceutical compositions and uses
RU2689161C1 (ru) * 2018-10-04 2019-05-24 Федеральное бюджетное учреждение науки "Казанский научно-исследовательский институт эпидемиологии и микробиологии" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека Способ получения бактериальных антигенов
KR20220025724A (ko) 2019-05-14 2022-03-03 더 유니버서티 오브 시카고 스타필로코커스 단백질 A(SpA) 변이체를 포함하는 방법 및 조성물
CN114929750B (zh) 2019-09-13 2024-11-22 芝加哥大学 用于治疗葡萄球菌感染的方法和组合物
CN111110838A (zh) * 2019-12-24 2020-05-08 华南师范大学 一种罗非鱼无乳链球菌疫苗及其制备方法
EP4154003A1 (de) * 2020-05-20 2023-03-29 Takeda Vaccines, Inc. Verfahren zur bestimmung der wirksamkeit von antigenen
CN111808977B (zh) * 2020-07-23 2023-06-27 清华大学深圳国际研究生院 一种由snp所引起利福平类抗生素耐药的抗性基因的特异性引物的设计方法及检测方法
US11820989B2 (en) 2020-11-04 2023-11-21 Eligo Bioscience Phage-derived particles for in situ delivery of DNA payload into C. acnes population
KR102281369B1 (ko) * 2021-04-07 2021-07-22 씨제이제일제당 (주) 신규한 디히드로리포일 아세틸기전이효소 변이체 및 이를 이용한 l-발린 생산 방법
KR102306010B1 (ko) * 2021-04-07 2021-09-27 씨제이제일제당 (주) 신규한 분지쇄아미노산 투과효소 변이체 및 이를 이용한 l-발린 생산 방법
CN116785418A (zh) * 2022-12-07 2023-09-22 深圳万可森生物科技有限公司 一种鱼源无乳链球菌亚单位疫苗及其制备方法与应用
CN120028542B (zh) * 2025-01-17 2025-11-25 宁夏医科大学 血清抗体IgG特异识别其疫苗株抗原谱及其筛选方法和应用

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69033600T2 (de) * 1989-03-09 2001-04-05 American Cyanamid Co., Madison Verfahren zur Isolierung von Haemopnilus influenzae Protein-E
US5980908A (en) * 1991-12-05 1999-11-09 Alfa Laval Ab Bacterial cell surface protein with fibronectin, fibrinogen, collagen and laminin binding ability, process for the manufacture of the protein and prophylactic treatment
US5456907A (en) 1992-01-10 1995-10-10 Helene Curtis, Inc. Cysteamine permanent wave composition and method
JPH11514870A (ja) * 1995-10-16 1999-12-21 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー 新規な唾液結合タンパク質
US6737248B2 (en) * 1996-01-05 2004-05-18 Human Genome Sciences, Inc. Staphylococcus aureus polynucleotides and sequences
RS50101B (sr) 1996-02-24 2009-01-22 Boehringer Ingelheim International Gmbh., Farmaceutski preparati za imunomodulaciju
US6380370B1 (en) * 1997-08-14 2002-04-30 Genome Therapeutics Corporation Nucleic acid and amino acid sequences relating to Staphylococcus epidermidis for diagnostics and therapeutics
EP1036321A1 (de) * 1997-12-05 2000-09-20 Intercell Biomedizinische Forschungs- und Entwicklungs GmbH Verfahren und zellen zum "screening" von "combinatorial libraries"
DE19803453A1 (de) 1998-01-30 1999-08-12 Boehringer Ingelheim Int Vakzine
WO1999057312A1 (en) * 1998-04-30 1999-11-11 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. New method for the selection of clones of an expression library involving rearraying
WO1999067376A1 (en) * 1998-06-25 1999-12-29 Institut Pasteur Exhaustive analysis of viral protein interactions by two-hybrid screens and selection of correctly folded viral interacting polypeptides
US6610836B1 (en) * 1999-01-29 2003-08-26 Genome Therapeutics Corporation Nucleic acid amino acid sequences relating to Klebsiella pneumoniae for diagnostics and therapeutics
AT407643B (de) * 1999-02-01 2001-05-25 Intercell Biomedizinische Forschungs & Entwicklungs Gmbh Verfahren zur selektion und herstellung von vakzin- und diagnostika-präparationen
US6936258B1 (en) * 1999-03-19 2005-08-30 Nabi Biopharmaceuticals Staphylococcus antigen and vaccine
CA2721199A1 (en) * 1999-05-05 2000-11-16 Phylogica Limited Isolating biological modulators from biodiverse gene fragment libraries
EP1238102B1 (de) * 1999-08-06 2008-11-12 Oragenics, Inc. Mikrobielle polynukleotide, die während der infekton eines wirts exprimiert werden
AT408721B (de) 1999-10-01 2002-02-25 Cistem Biotechnologies Gmbh Pharmazeutische zusammensetzung enthaltend ein antigen
JP4852211B2 (ja) 2000-03-21 2012-01-11 メルク アンド カンパニー インコーポレイテッド 原核生物における必須遺伝子の同定
RU2293573C2 (ru) 2000-06-08 2007-02-20 Интерселл Аг Иммуностимулирующие олигодезоксинуклеотиды
GB0014907D0 (en) * 2000-06-20 2000-08-09 Univ Sheffield Antigenic polypeptides
US20040170642A1 (en) 2000-08-17 2004-09-02 Jorg Fritiz Vaccine which comprises at least one antigen and a cathelididin derived antimicrobial peptide of a derivative thereof
AT410635B (de) 2000-10-18 2003-06-25 Cistem Biotechnologies Gmbh Vakzin-zusammensetzung
AT410798B (de) 2001-01-26 2003-07-25 Cistem Biotechnologies Gmbh Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen
AU2002306849A1 (en) 2001-03-21 2002-10-08 Elitra Pharmaceuticals, Inc. Identification of essential genes in microorganisms
GB0107661D0 (en) * 2001-03-27 2001-05-16 Chiron Spa Staphylococcus aureus
EP2320233A1 (de) 2001-06-15 2011-05-11 Inhibitex, Inc. Kreuzreaktive monoklonale und polyklonale Antikörper, die Oberflächenprotein aus Koagulasenegativen Staphylococci und Staphylococcus aureus erkennen
WO2003011899A2 (en) 2001-08-02 2003-02-13 University Of Sheffield Antigenic polypeptides
SI1651166T1 (sl) 2003-07-24 2010-06-30 Merck Sharp & Dohme Polipeptidi za induciranje zaščitnega imunskegaodgovora proti stafilokoknem eureusu
EP1734615B1 (de) 2005-06-13 2008-10-08 Research In Motion Limited Elektrischer Verbinder und elektrisches System für ein Bauteil in einem elektronischen Gerät

Also Published As

Publication number Publication date
DE60207194T2 (de) 2006-08-03
RU2289817C2 (ru) 2006-12-20
AU2010200549A1 (en) 2010-03-04
EP1630172B1 (de) 2015-06-10
US7771728B2 (en) 2010-08-10
EP2319861A1 (de) 2011-05-11
ATA1302001A (de) 2002-12-15
CN101492496A (zh) 2009-07-29
US20080038287A1 (en) 2008-02-14
AU2002247641B8 (en) 2008-03-13
IL211037A (en) 2013-07-31
US20110020402A1 (en) 2011-01-27
KR20080029016A (ko) 2008-04-02
NZ551802A (en) 2008-04-30
AT410798B (de) 2003-07-25
JP2008291035A (ja) 2008-12-04
US7968297B2 (en) 2011-06-28
ZA200305764B (en) 2004-07-26
IL186706A0 (en) 2008-02-09
CZ20032201A3 (en) 2004-03-17
PL367125A1 (en) 2005-02-21
EP1616876A3 (de) 2006-04-12
PL214482B1 (pl) 2013-08-30
KR100851728B1 (ko) 2008-08-11
CA2436057C (en) 2012-12-18
HUP0402048A2 (hu) 2005-01-28
CA2436057A1 (en) 2002-08-01
ES2252438T3 (es) 2006-05-16
IL211037A0 (en) 2011-04-28
HUP0402048A3 (en) 2010-01-28
BR0207067A (pt) 2004-06-15
RU2003125967A (ru) 2005-03-10
JP2004531476A (ja) 2004-10-14
NO20033364L (no) 2003-09-24
CA2792244A1 (en) 2002-08-01
WO2002059148A2 (en) 2002-08-01
EP1355930A2 (de) 2003-10-29
EP1630172A3 (de) 2006-05-03
US8715688B2 (en) 2014-05-06
KR20030082574A (ko) 2003-10-22
EP1355930B1 (de) 2005-11-09
CN1649894A (zh) 2005-08-03
PL209115B1 (pl) 2011-07-29
IL186706A (en) 2010-12-30
US20130034575A1 (en) 2013-02-07
AU2007234519A1 (en) 2007-12-13
IS6895A (is) 2003-07-25
KR20080107477A (ko) 2008-12-10
WO2002059148A3 (en) 2003-07-31
EP1616876A2 (de) 2006-01-18
NZ565349A (en) 2009-07-31
AU2002247641B2 (en) 2007-08-23
JP5053933B2 (ja) 2012-10-24
NO20033364D0 (no) 2003-07-25
IL211038A0 (en) 2011-04-28
AU2007234519B2 (en) 2009-11-12
KR20090101973A (ko) 2009-09-29
NZ540764A (en) 2008-03-28
ATE309268T1 (de) 2005-11-15
WO2002059148A9 (en) 2002-10-31
NZ527440A (en) 2006-02-24
DE60207194D1 (de) 2005-12-15
PL392964A1 (pl) 2011-01-03
US8323660B2 (en) 2012-12-04
WO2002059148A8 (en) 2003-01-16
EP2412722A1 (de) 2012-02-01
DK1355930T3 (da) 2006-03-06
MXPA03006702A (es) 2005-04-08
KR100901915B1 (ko) 2009-06-10
IL157082A0 (en) 2004-02-08
EP1630172A2 (de) 2006-03-01
US20050037444A1 (en) 2005-02-17
EP2322539A2 (de) 2011-05-18
EP2322539A3 (de) 2011-09-07

Similar Documents

Publication Publication Date Title
SK10492003A3 (sk) Spôsob identifikácie, izolácie a produkcie antigénov špecifického patogénu
AU2002247641A1 (en) A method for identification, isolation and production of antigens to a specific pathogen
JP2004531476A5 (de)
AU2006249236B2 (en) A Method for Identification, Isolation and Production of Antigens to a Specific Pathogen
HK1135405A (en) A method for identification, isolation and production of antigens to a specific pathogen
HK1081206A (en) A method for identification, isolation and production of antigens to a specific pathogen

Legal Events

Date Code Title Description
FD9A Suspended procedure due to non-payment of fee